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Konuralp Medical Journal / Konuralp Tıp Dergisi
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  This is an Open Access Journal Open Access journal
ISSN (Print) 1309-3878 - ISSN (Online) 1309-3878
Published by Düzce Üniversitesi Homepage  [4 journals]
  • Evaluation of North Syrian Women Knowledge, Opinions and Attitudes
           Regarding Milk Banks and Milk Donation

    • Authors: Nazlı ÇELİK; Bahadır KARACA, Burak ÇELİK, Nihal BEREKET, Sibel KORKMAZ
      Abstract: Objectives: To investigate Syrian mothers' knowledge, attitudes, and opinions on milk banks and raise awareness of the opening of milk banks in the region.Methods: Our study was conducted hospitals in North Syria between 02/12/2020 and 02/03/2021. 536 women included in our study. Our questionnaire, which was written in Arabic to assess knowledge, opinions and attitudes toward milk donation and milk banks, was administered to participants during face-to-face interviews.Results: All participants were female and Muslim, with a mean age of 29.79∓7.69 years. 47.2% of the participants agreed that a milk bank should be established, while 37.5% of the participants were against it. 81.3% women favored establishing a milk bank said that they would use the milk bank if they could not breastfeed (p=0.000). 49.4% were against establishing milk banks due to religious inconvenience. 41.5% of participants who favored establishing a milk bank and 14.4% of those who were against it indicated that the facility would have a positive impact on them under the guarantee of Turkey (p=0.000).Conclusion: Due to religious views in Muslim societies, there is a negative attitude toward milk banks. Therefore, establishing robust registration systems, involving religious leaders in the process, providing accurate information, and educating the society will raise awareness and change the negative view.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Using Smartphone to Evaluate Cranial Computed Tomography Videos: An
           Inter-Observer Study

    • Authors: İbrahim Feyyaz NALDEMİR; Ahmet Kürşat KARAMAN, Mustafa BOĞAN, Hasan Baki ALTINSOY, Mehmet KARADAĞ
      Abstract: Objective: Many clinicians receive Cranial Computed Tomography (CCT) images or videos by their smartphone. The aim of this study was to evaluate the reliability of the CCT videos that are shared through smartphone in the diagnosis. Method: The CCT videos that were sent via WhatsApp were examined in 9 sections: soft tissue, bone structure, parenchyma, ventricle, vascular structures, middle ear, orbits, sinuses and the extra axial space. Result: The CCT videos were analyzed in 9 sections; there was a perfect agreement among specialists in one of these sections, good agreement in 6 and poor agreement in 2. When compared with the gold standard, it was shown that 5 out of 9 sections could be an alternative to the gold standard. Conclusion: It may be thought that evaluation of the CCT videos can be obtained with messenger applications such as WhatsApp, which is a cheap, fast and common application. But this study shows that diagnostic images and videos shared through the smartphone by a messenger application can not be an alternative to standard evaluations.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Evaluation of Pediatric Patients with First Seizure

    • Authors: Sevgi ÇIRAKLI; Hediye USTA, Ali AYGUN
      Abstract: Objective: Pediatric seizure is a condition that occurs due to many different underlying causes and causes fear and anxiety in families. In our study, it was aimed to evaluate pediatric seizure cases who applied to our hospital.Material and Methods: Patients aged 0-18 years, who applied to the pediatric emergency department of our hospital between May 2018 and May 2020, were retrospectively analyzed. The patients were evaluated in terms of age, gender, seizure types, familial genetic predisposition, examination, treatment and follow-up. Seizures were divided into 2 groups as focal and generalized according to the International League Against Epilepsy (ILAE) 2017 classification. The treatment methods applied with cranial magnetic resonance imaging and electroencephalography recordings of the patients were evaluated.Results: Of the 118 patients included in the study, 70 (59 %) were girls and 48 (41 %) were boys. The mean age was 60 (3-192) months. Family history was present in 18 (15 %) cases. 8 (7 %) of the seizures are partial and 110 (93 %) of them are generalized. Since seizure recurrence was observed within 24 hours in 5 of 36 patients who were evaluated as febrile seizures, they were evaluated as complicated febrile seizures and drug treatment was started. The other 31 patients were evaluated as simple febrile seizures. There was no biochemical abnormality in the seizure etiology in any of the cases. Cranial magnetic resonance imaging revealed polymicrogyria in 2 patients, hydrocephalus in 2 patients, brain tumor in 1 patient, and arteriovenous malformation in 1 patient.Conclusions: In cases presenting with seizures, the underlying causes should be identified and their treatment should be arranged. Cases with recurrent seizures should also be followed closely.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Decreased Oxidative Stress Markers in Patients with Active and Generalized
           Vitiligo

    • Authors: Yunus OZCAN; Ebru KARAGÜN, Merve ALPAY
      Abstract: ObjectiveOxidative stress has been shown to play a role in the pathophysiology of several diseases, making it a popular yet contentious research area. There is some evidence that selective melanocyte destruction may have developed in vitiligo patients as a result of elevated oxidative stress. The purpose of this study is to investigate the impact of oxidative stress on lipid, protein, and nucleic acid metabolism in vitiligo patients.MethodWe used ELISA method to measure serum oxidative stress markers in patients with generalized vitiligo who had newly formed lesions in the previous three months but had not been treated, as well as healthy controls. Malondialdehyde (MDA), 2,4-dinitrophenyl hydrazone (DNPH), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and uncoupling protein 2 (UCP2) levels were measured to assess the influence of reactive oxygen derivatives on lipid, protein, nucleic acid metabolism, and mitochondria, respectively. ResultsThe study included 84 participants, including 64 active generalized vitiligo patients and 20 healthy controls with similar age and gender distribution. In the serum of vitiligo patients, we detected significantly lower levels of MDA (ng/mL, mean±SD=12±19; 33.4±35.9), DNPH (ng/mL, mean±SD=2±3.1; 6±7.4), 8-OHdG (ng/mL, mean±SD=11.7±17.9; 32.7±37) and UCP2 (ng/mL, mean±SD=8.7±13.7; 21.5±28.4).ConclusionAlthough there is significant evidence that oxidative stress plays a role in the pathophysiology of vitiligo, the studies should be interpreted cautiously due to the heterogeneity in the methodology, complexity of the oxidative stress pathways, and potential publication bias. Large-scale studies using a standardized methodology are required to determine how significant oxidative stress is in the core pathophysiology of vitiligo and which pathways it primarily affects.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • A Field Study on Determining the Social Media Addiction Levels of
           Academicians: Validity and Reliability Study

    • Authors: Hakan Tahiri MUTLU; Rengim SİNE NAZLI, Gülşah SARI
      Abstract: Objective: The main purpose of this research was to find out the social media addiction levels of academicians and to reveal whether the scale used is a valid and reliable scale. In addition, it is another aim of the study to determine which variables differ in terms of social media addictions of academics whose social media addiction levels are determined. Methods: A total of 430 academicians, 199 of whom were females and 231 males, participated in this study. The validity and reliability of the scale were tested by performing exploratory and confirmatory factor analyzes and reliability analyzes on the data collected from the academicians reached by the online survey method. Then, the differences of the factors, whose validity and reliability were ensured by using parametric techniques, according to demographic variables were examined.Results: The exploratory factor analysis done on the data collected from academicians reached by online survey method, showed that the scale had four sub-factors called Virtual Tolerance (Slacking), Virtual Interaction, Virtual Communication, and Emotional State. Obtained sub-factors were subjected to confirmatory factor analysis and it was seen that the fit indices gave good results. Since the Cronbach's alpha value, which was used to measure the reliability of the scale, was also high, the scale used to measure the social media addiction levels of academicians was found to be valid and reliable. The differences of the factors that were found to be valid and reliable according to demographic variables were examined. Conclusions: The result of the analysis demonstrated that addiction levels of single academicians were more than that of the married academicians; young or old academicians’ social media addiction levels were more than that of middle-aged academicians. Clearly, this study revealed that as the academic title increases, social media addiction levels of academicians decreases.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Evaluation of the Effect of Comorbid Bronchiectasis on Quality of Life in
           Patients with Chronic Obstructive Pulmonary Disease

    • Authors: Cansu YILMAZ; Murat ACAT, Serkan ÖNER, Habibe İNCİ, Didem ADAHAN
      Abstract: Objective: The objective of this study was to evaluate the effect of comorbid bronchiectasis on quality-of-life in patients with Chronic Obstructive Pulmonary Disease (COPD).Method: 103 patients were diagnosed with COPD were included in our study. Spirometric measurements were made. The following measurement tools were used to collect data: 6-Minute Walk Test (6MWT), Modified Medical Research Council (mMRC) dyspnea scale, COPD Assessment Test (CAT), St. George Respiratory Questionnaire (SGRQ), and Short Form 36 (SF-36) quality-of-life questionnaire. Furthermore, all the patients’ high Resolution Computed Tomography (HRCT) images for the last three years were included in the study.Result: 93.2% of the patients were male, with a mean age of 64.79±9.35 years. It was found that SGRQ and SF-36 quality-of-life scores decreased by half in all the patients compared to normal ones. The volume/forced vital capacity (FEV1/FVC) values in the first second of forced expiration were significantly lower in the group with bronchiectasis. A significant correlation was found to exist between the patients’ mMRC dyspnea scale and CAT scores, 6MWT distances, and all subscales of SGRQ and SF-36. In addition, a significant correlation was also found to exist between FEV1 values and all subscales of SGRQ, and between subscales of SF-36.Conclusion: In our study, when we compared the quality-of-life scores of the patients with COPD and bronchiectasis with those with COPD alone, we found that the quality-of-life of both groups was impaired, but there was no significant difference between them.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Clinicopathological features of Gastrointestinal Stromal Tumors and review
           of the literature

    • Authors: Sinem KANTARCIOĞLU COŞKUN
      Abstract: Objective: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasias of the gastrointestinal system (GIS). The malignancy potential of GISTs may vary ranging from indolent tumors to progressive malignant tumors. This study aims to define clinicopathological and immunohistochemical features of GISTs diagnosed in our institute with a review of the literature.Method: A total of 28 GIST cases were included in the study. The Hematoxylin&Eosin stained slides of surgical resection materials and cell blocks and immunohistochemistry performed slides were reviewed by a pathologist. The immunohistochemical expression with CD117, DOG-1, CD34, SMA, and S100 was scored between 0 and 3 points according to staining intensity. Descriptive statistics were used in the study. The demographic data, prognostic histopathological, and immunohistochemical findings are evaluated with the literature indications.Result: Eleven of the cases were male and seventeen were female. The age range was 18-88. The most common site of GISTs was the stomach, followed by the small intestine, colorectal region, and, esophagus. Twenty of the tumors were resected surgically, four were endoscopic biopsy material and four were fine-needle aspiration biopsies. The tumor size in measurable materials ranged from 0,2 to 22 cm. The mitotic count in 50 HPF ranges from 0 to 10. Seven of the GISTs were high grade and the remaining 21 were low grade. The majority of the cases were composed of spindle cells, 3 were epithelioid and 3 were the mixed type with spindle and epitheloid cells.Conclusion: A variety of criteria has been proposed to estimate the malignancy potential of GISTs and predict prognosis but definite prognostic criteria remain uncertain. Further studies with larger series of GISTs consisting of different types of biopsy materials may help define criteria to predict prognosis precisely.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Interleukin-23R Gene Polymophisms in Patients with Diabetic Peripheral
           Polyneuropathy

    • Authors: Özgül OCAK; Fatma SILAN
      Abstract: Objective: Proinflammatory and neurovascular changes are blamed in the pathogenesis of diabetic neuropathy. Although it is accepted that diabetes is a trigger for vascular inflammation, it has been suggested that inflammation itself may trigger diabetes. Interleukin-23 (IL-23) is a pro-inflammatory cytokine secreted by activated macrophages and dendritic cells. Interleukin-23R is known to have a critical role in chronic inflammatory diseases. The aim of this study is to determine the relationship between IL-23R polymorphism and diabetic peripheral neuropathy.Method: 50 diabetic peripheral neuropathy patients who applied to Neurology outpatient clinic, and 52 healthy controls compatible with the patient group in terms of age and gender were included. Electromyography was performed on all of the volunteers, who agreed to participate in the study, and 2 ml of blood samples were taken into tubes with EDTA, and the IL-23R gene polymorphism was analyzed using the pyrosequencing method.Results: IL-23R gene variants rs2201841, rs199542433, rs201052419, rs11209026 were analyzed in diabetic peripheral neuropathy (DPN) patients and control group. While we investigate IL23R polymorphisms we didn’t find any significant differences between patient and control groups. But when we use odds ratios, rs2201841 seems to have a protective role, and rs199542433 in both dominant and recessive models and rs11209026 only recessive model seem to be related 10 fold higher risks for DPN.Conclusion: IL-23R gene polymorphism has been shown to be associated with many autoimmune and inflammatory diseases. It is known that inflammation has an important effect on diabetes. The frequency of IL-23R gene polymorphism was not significant in diabetic peripheral neuropathy. Our study is the only and first study investigating the role of IL-23R gene polymorphism in diabetic peripheral neuropathy. Ethnicity is very important in genetic studies, and it will give us more clear information for the future to carry out this study in patients with other ethnic origins and to recruit larger study groups.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Does Saccharin Have Effect on Appetite, Energy Intake, and Serum
           Ghrelin' A Randomized, Controlled, Cross-Over Study in Healthy Males

    • Authors: Aylin BAYINDIR GÜMÜŞ; Alev KESER, Esra TUNÇER, Tuğba ALTUNTAŞ YILDIZ, İlknur KEPENEKCİ BAYRAM
      Abstract: Objective: Instead of sugar, artificial sweeteners that do not contain energy are widely used. However, contrary to popular belief, artificial sweeteners are thought to affect metabolism. Thus, purpose of this present study was to evaluate effects of saccharin on serum ghrelin, appetite, and food consumption.Method: Nine healthy males aged 20-29 participated in the randomized, controlled, and cross-over study. Each participant received 300 ml water, and 300 ml water containing 75 grams sucrose and 240 milligrams saccharin. At baseline, 30th, 60th, 90th, 120th, and 180th min, Visual Analog Scale was applied to evaluate appetite, and blood samples were taken to analyze ghrelin. After 180th min, participants consumed ad libitum diet, and kept 24-hours dietary food intake records until the end of this day. Results: At 60th and 120th min, mean ghrelin level was higher in drinks containing only water and saccharin compared to drink containing sucrose (p
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Lifelong Learning Tendencies of Faculty of Medicine Students

    • Authors: Albena GAYEF; Çağrı ALPTÜRK
      Abstract: Objective: The aim of this study is to determine the lifelong learning tendencies of the students studying at the medical faculty and whether there is a relationship between lifelong learning tendencies and gender, grade level variables.Methods: In the study, “Lifelong Learning Tendency Scale”, sociodemographic question form were applied face to face to the medical faculty students (n= 196) in the 2019-2020 academic year. Statistical evaluation was made with the SPSS statistical program. Mean, standard deviation, frequency, percentage, Mann Whitney U, Kruskall Wallis tests were applied. Results: Means of motivation, persistence, deprivation in regulating learning, deprivation in curiosity subdimensions, total score average are 6.43 + 2.43; 18.9 + 6.23; 24.48 + 5.05; 24.5 + 6.54; 74.34 + 9.56 respectively. The mean levels of females in motivation and deprivation in regulating learning were significantly lower than males; males’ total score mean was significantly higher than females (p
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • The Opinions of Family Medicine Residents about Education and Working
           Conditions in Turkey

    • Authors: Ümmü DOĞAN; Nazan KARAOĞLU
      Abstract: Objective: In residency education, the educational environment interacts with each component of the training. This study is intended to assess the perceptions of family medicine residents about the educational and working environments from their point of view and to reveal their problems and expectations. Methods: In this descriptive and cross-sectional study, nationwide 434 family medicine residents’ opinions about their educational environment were collected using a survey prepared by the researchers.Results: The mean age of the residents was 29.26±4.31 years. Women constituted 70.5% (n=306) of participants and 53.7% (n=233) chose family medicine career due to its working conditions. The rate of those who stated that there were no educational family health centers was 57.1% (n=248). More than half (67.5%; n=293) were satisfied with the department that they are getting education. Institutional assessment score (IAS) of those who chose family medicine for working conditions and obligations was lower than the participants who chose it because of their love and interest (p
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • The distribution and the related factors of forward head posture among
           medical students

    • Authors: Elif KÖSE; Hüseyin BAYLAN, Hilal KARAHAN, Hasan EKERBİÇER
      Abstract: Objective: Forward head posture (FHP) is becoming common in medical students who study for long durations with wrong postures due to intensive curriculum. This study was conducted to determine the frequency of FHP and related factors in medical students.Method: The first and second-year medical students filled out the questionnaire including sociodemographic characteristics, activity status, Smartphone Addiction Questionnaire, Beck Depression, Body Awareness, and Perceived Stress Scales after their verbal consent was obtained. FHP and craniovertebral angle values were measured.Results: 47% of the students had highly severe (≥5 cm), 46.2% had severe FHP (2.5-5 cm), and 6.8% had mild FHP. The mean CVA (Costovertebral Angle) values were determined as 44.31 ± 4.31. The frequency of students whose CVA values are below 45° is 59.3% (140 people). The frequency of highly severe FHP was also found as high in the taller, in males, and in the students with high BMI. In the regression model examining the situations that increase the risk of severe FHP, it was found that depression increased the risk of FHP 2.5 times.Conclusion: FHP was found to be very common (90%) in medical students. FHP was found to be more severe in students with high depression scores.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • GastroClinicopathologic Characteristics of Gastrointestinal Stromal Tumors
           and Prognostic Importance of Ki-67 Labeling Index: May be a New Prognostic
           Marker

    • Authors: Sıddıka FINDIK; Gül KANYILMAZ
      Abstract: Objective: The biological behavior of gastrointestinal stromal tumors (GISTs) varies widely and it is diffucult to predict their malignant potential with the current risk classification criterias. Therefore, we aimed to analyse the prognostic importance of Ki-67 LI for estimating survival outcomes in patients with GISTs.Methods: For the last 11 years, between 2006 and 2017, who had been treated after surgery were included. A single pathologist re-defined the histologic examples of all cases retrospectively.Results: Totally, 104 patients were included in the study. The median follow-up time was 73 months (range; 6 to 148 months). Seven of the 104 patients (7%) had local recurrence, 26 of the 104 patients (25%) had distant metastases and 11 of the 104 patients (11%) died during the follow-up period. The mean OS was 133 (range; 124 to 141) and the mean DFS was 117 (range; 107 to 127) months for patients. The disease progression or recurrence during follow up and increasing age were the significant prognostic factors for OS. Mitotic count, growth pattern, tumor location and Ki-67 LI were the significant prognostic factors for DFS. According to multivariate analyses, the Ki-67 LI was the only prognostic factor for estimating disease progression or recurrence (p=0.04). Conclusion: The most important prognostic factors that affect OS were the age and disease progression or recurrence of disease. Ki-67 LI was the only prognostic factor for estimating disease progression or recurrence. As the follow-up period increases, we think that Ki-67 LI also will affect overall survival.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • The Relationship of Early Repolarization Morphology with Prognosis and
           Mortality Accompanied by Angiography Results

    • Authors: Burak DEMİRCİ; Çilem ÇALTILI, Abuzer COŞKUN
      Abstract: Objective: Early repolarization (ER) is a common finding in cases. It can be benign or malignant. We aimed to evaluate the effects of early repolarization morphology and electrocardiogram (ECG) findings on the clinic, prognosis, and mortality with angiography findings.Method: This retrospective study included 442 patients who were admitted to the emergency department between January 2010 and December 2015 and had ER in their ECG. The patients were divided into two groups according to the horizontal and ascending ER morphology. According to the derivation, four groups were formed as inferior, inferolateral, anterior, and common. Besides, four groups were determined according to the angiography findings: left anterior descending (LAD), circumflex (Cx), right coronary artery (RCA), and normal.Results: The average age of the patients in the study was 52.16±9.07 years and 260(58.8%) were male. Horizontal morphology was observed in 123(28%) of the patients and ascending morphology in 319(72%). Mortality was detected in 9(7.3%) of the horizontal group and 6(1.9%) of the ascending group (p=0.008). In the angiography results of the mortality group, 8(53.3%) patients had Cx, 4(26.7%) patients had RCA and 3(20%) patients had LAD occlusion. Angiography results of 318(74.5%) surviving patients were normal (p=0.001). Mortality; It had a strong positive correlation with family history, Brugada Syndrome, aVR ST-segment formation and the presence of syncope, and moderate positive correlation with gender, notch presence, QRS morphology in V1-2, and angiography results.Conclusions: Early repolarization morphology may be a helpful finding for prognosis, mortality, and interventional angiography decisions.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Paraneoplastic Severe Sensorimotor Axonal Polyneuropathy in Pancreatic
           Neuroendocrine Carcinoma: A Case Report and Review Of The Literature

    • Authors: Türkay AKBAŞ; Sinem Coşkun KANTARCIOĞLU, Serkan TORUN, Ayhan ÖZTÜRK, Onur EŞBAH, Ömer ÖNBAŞ
      Abstract: Objective: Paraneoplastic neurological syndromes (PNSs) are a diverse group of neurological disorders affecting any part of the nervous system before or during cancer. Case: A 78-year-old patient had pain and burning sensation first in the upper extremity 3 years ago, and then, muscle weakness was added a short time later. The same symptoms developed in the lower extremities 1 year ago. He was admitted to the intensive care unit due to pneumonia and was conscious but quadriplegic with a modified Rankin score of 5. Abdominal computed tomography showed mass lesions in the liver and pancreas. The biopsies demonstrated pancreatic small cell neuroendocrine carcinoma. Electrophysiological studies disclosed severe sensorimotor axonal polyneuropathy. Since other polyneuropathy causes were excluded, the diagnosis was paraneoplastic sensorimotor axonal polyneuropathy. Palliative care was considered because the patient had a poor functional state. Conclusion: Early cancer diagnosis is paramount in patients with PNSs to have appropriate therapy.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • The Effect of a Mobile Phone Application on Smoking Cessation

    • Authors: Selçuk MISTIK; Cemalinur UZUN, İnci GÜLMEZ
      Abstract: Objective: The aim of this study was to investigate whether these applications are effective in quitting smoking by using one of the smartphone applications in addition to motivational interviewing in patients who applied for giving up smoking.Materials and methods: A randomized controlled intervention study was between January and July 2020. Adults aged 18-65 years who smoke at least one cigarette a day were included in the study. In the prospective study, the patients were followed for 6 months and a total of ten interviews were made. A phone application was installed on the intervention group. Afterwards, the smoking status of the patients was evaluated by telephone or face-to-face. Results: Sixty-three smokers participated in the study. Fifty patients completed the study, 25 controls and 25 interventions. Long-term smoking cessation findings at the first, third and sixth months were evaluated for both groups. Success rate in the first month was 64% for intervention group and 32% in the control group; for the third month it was 56% in the intervention group and 32% in the control group for the sixth month it was 44% in the intervention group and 24% in the control group.Conclusion: The smartphone mobile-application showed a positive effect in promoting the increase in the smoking quitting rate. The intervention was found to be effective in 30-day smoking cessation success. Despite higher smoking quitting rates at 3 and 6 months, the application was not effective.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Determining the Vasohibin-1 Levels of the Serum and Broncoalveolar Lavage
           Fluid in the Patients with Lung Cancer”

    • Authors: Alev LAZOGLU; Mevlüt Sait KELEŞ, Esra LALOĞLU, Elif YILMAZEL UCAR, Sinan YILMAZ
      Abstract: Objective: Lung cancer constitutes 17% of all cancer cases and accounts for 23% of the deaths caused by cancer all over the world. Vasohibin-1 (VASH-1) is an angiogenesis-inhibiting factor synthesized by endothelial cells (ECs). This study aimed to examine the VASH-1 levels of the bronchoalveolar lavage (BAL) and serum in the patients with lung cancer.Material and Method: A total of 82 patients participated in this study. 39 and 43 of them had a benign lung disease and lung cancer, respectively. The VASH-1 levels of serum and BAL were measured using the Enzyme-Linked Immunosorbent Assay (ELISA).Results: The BAL VASH-1 levels of the patients in the lung cancer group were found to be statistically significantly lower than those of the patients in the benign lung disease group (p=0.032). No statistically significant difference was found between the individuals with lung cancer and benign lung disease in terms of the serum VASH-1 concentration (p=0.206). A statistically significantly moderate positive correlation was found between the serum and BAL VASH-1 levels in the benign and malignant cases (benign r=0.442, p=0.005; malignant r=0.364, p=0.016). When the lung cancer patients were categorized into pathological stages and histological types, no significant difference was found between the stages and histological types in terms of the serum and BAL fluid VASH-1 concentrations.Conclusions: BAL VASH-1 concentrations decreased in the lung cancer patients compared to the individuals having a benign lung disease. Considering the results reached in this study, it was thought that the BAL VASH-1 concentrations might be beneficial in distinguishing between the benign and malignant lung diseases.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Epidemiological and Clinical Characteristics of Shoulder Dislocations in
           Emergency Care Settings in Turkey: A Single-Center Experience

    • Authors: Murat ÇETİN; Nurcan BIÇAKÇI, Sercan BIÇAKÇI, Neil J CUNNINGHAM
      Abstract: Objective: This study evaluated the general epidemiological and clinical characteristics of patients admitted to the emergency department with shoulder dislocations. Methods: This is a retrospective cross-sectional study, conducted as a chart review at the Emergency Department of the *** State Hospital between 01 January 2018 to 31 December 2019. Results: A total of 165 patients (median age 50 years and 60% of males) with anterior shoulder dislocations were included. The most common mechanism was traumatic dislocation (65.5%), the primary maneuver of treatment was traction/countertraction (80.6%), and 22.4% were recurrent dislocations. Males were younger and had more spontaneous dislocations. Also, patients with spontaneous dislocations were younger and predominantly males, and tended to be recurrent dislocations than traumatic ones. Conclusions: Epidemiological characteristics of our patients were similar to a previous study conducted in Turkey, but slightly different from the studies in other populations. Further studies evaluating the incidence and long-term follow-up data are also needed to better elucidate the epidemiological features of shoulder dislocations.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • The Evaluation of Relationship Between Monocyte/High-Density Lipoprotein
           Ratio (MHR) and COVID-19

    • Authors: Belgin COŞKUN; Müge AYHAN, Elif Mukime SARICAOĞLU, Rahmet GÜNER, Esragül AKINCI, Turan BUZGAN, Bircan KAYAASLAN, Adalet AYPAK, Ayşe Yasemin TEZER TEKÇE, İmran HASANOĞLU, Ayşe KAYA KALEM, Fatma ESER, Yeşim AYBAR BİLİR, Burcu ÖZDEMİR
      Abstract: Objective: Early diagnosis is important for severe diseases in COVID-19. Monocyte/high dansity lipoprotein ratio (MHR) is a new prognostic marker indicating inflammation. We aimed to investigate the relationship between MHR and diseases severity in COVID-19.Materials and Methods: Patients with laboratory confirmed COVID-19, were retrospectively analyzed. Clinical symptoms, signs and laboratory data on the first day of hospitalization were obtained from medical records of hospital. The clinical data of 301 patients were included in study. Cases were diagnosed on the basis of interim guidance of World Health Organization (WHO). Patients were classified into two groups as non-severe COVID-19 and severe COVID-19. MHR were calculated with laboratory data on the first day of hospitalization. The relationship between MHR level and COVID-19 severity was evaluated. Statistical analysis of the data was performed by using SPSS 25 (SPSS Inc., Chicago, IL, USA) package program. Statistical significance level was accepted as p
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
  • Analysis of the efficiency and cost of a care bundle for prevention of
           common infections in an intensive care unit: A quasi-experimental
           pretest-posttest design study

    • Authors: Gülay YAZICI; Hülya BULUT, Burcu BAYRAK KAHRAMAN, Tunçay PALTEKİ
      Abstract: ObjectiveHealthcare-associated infections, threaten patient safety, cause prolonged hospitalization, morbidity, mortality and increased costs. This study was conducted to evaluate the effectiveness of interventions to prevent healthcare-associated infections and the effect of these interventions on cost.MethodsA quasi-experimental pretest-posttest design study was completed between 1 January and 30 June 2018, and 1 October 2018 and 31 March 2019, in an intensive care unit, with a total of 54 patients, 27 pre-training and 27 post-training.ResultsIn the study, infection rates were 20.34 in January to March 2018, 25.7 in April to June 2018, 20.97 in October to December 2018 and 17.77 in January to March 2019. When the infection rates of the four different periods were compared, it was found that there was a decrease compared to the pre-training period but that this decrease was not statistically significant (p>0.05). The average cost before the training was 11361.35₺ and the average cost after the training was 9149.87₺. Average bed costs, which are the most important of all costs, decreased by 25.7% compared to pre-training at the 95% confidence interval (5241.86₺-13251.50₺ and 3489.03₺-10257.41₺, respectively).ConclusionIn conclusion, the study determined that training provided a significant increase in the intensive care nurses’ scores related to healthcare-associated infections and there were decreases in healthcare-associated infection rates, lengths of hospital stay and cost after the training although these were not statistically significant.
      PubDate: Wed, 29 Jun 2022 00:00:00 +030
       
 
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