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Current trends in Biotechnology and Pharmacy     Open Access   (Followers: 8, SJR: 0.123, CiteScore: 0)
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Current trends in Biotechnology and Pharmacy
Journal Prestige (SJR): 0.123
Number of Followers: 8  

  This is an Open Access Journal Open Access journal
ISSN (Online) 0973-8916
Published by Association of biotechnology and pharmacy Homepage  [1 journal]
  • In Vitro and In Vivo Studies of Argemone mexicana Linn. Extracts Against
           Cobra Venom (Naja naja) Induced Toxicity

    • Authors: Jayakara Miriam, Raghavan Srimathi, Gurunathan Jayaraman
      Pages: 01 - 08
      Abstract: In accordance to ethnobotanical reports, the plant Argemone Mexicana Linn. possess anti-ophidian properties. The current study is focussed on the inhibition property of the medicinal plant extracts against selective activities (PLA2 and hemotoxic) of Indian cobra venom. In vitro studies showed 100% PLA2 inhibition (1:50) and 100% inhibition of hemolysis activity of Naja naja venom (1:80) by methanolic extract of A. Mexicana. In vivo studies were carried out to determine the ED50 value of the selected extracts. Histopathology analysis revealed that A. mexicana methanolic extract has proved its potential to inhibit the Naja naja venom-induced toxicity and paw edema studies revealed a reduction in the toxicity upon treatment with the methanolic extract.
      PubDate: 2022-06-15
      DOI: 10.5530/ctbp.2022.2s.25
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Assessment of Developmental Toxicity of Indigo (Indigofera tinctoria L.) -
           An Industrially Important Dye in Zebrafish (Danio rerio)

    • Authors: Sasi Bhushan , Siva Ramamoorthy
      Pages: 09 - 14
      Abstract: Chemically synthesized dyes have been used, mainly in textile industries for dyeing textile fabrics. Even though natural dyes have had a long history of being used to dye textiles, their importance and use have gradually reduced due to superior color fastness and their synthetic counterparts’ cost-effectiveness. However, it can cause harm to the environment (water) and its associated life (mainly aquatic) if not disposed of properly. Certain synthetic azo dyes, owing to their detrimental effects on the environment, have since been banned. Indigo, obtained primarily from Indigofera tinctoria L. is one of the first dyes to be used by mankind and is still in use. Synthetic Indigo is predominantly used and preferred over natural Indigo because synthetic Indigo gives a better- finished look, and natural Indigo yield is too low to meet the denim industry’s demands. In this study, natural Indigo extracted from the leaves of I. tinctoria L., and synthetic Indigo were characterized using FTIR and UV spectroscopic techniques. The develop-mental toxicity of the dye was studied on Zebrafish (Danio rerio) embryos. Lethal concentrations, abnormalities caused by the dye and morphological changes of the embryos have been studied. Toxicity levels were evaluated by calculating the LD50 values on the embryonic stages at 24h, 48h, and 72h. Morphological changes were noted using microscopic observations. Sublethal effects (spinal curvature, loss of pigmentation of the embryos) were observed in higher concentrations of the synthetic dye as well as the natural dye, but in lower concentrations, there was normal development of the Zebrafish embryos. In light of the study, there is a need for proper disposal of the by-products (during the production process) and the dye itself.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.26
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • In Vitro Analysis of Antimicrobial Compounds from Euphorbia milli

    • Authors: Danie Kingsley, Jayanthi Abraham
      Pages: 15 - 27
      Abstract: Pharmaceutical and scientific communities are now looking at newer avenues of obtaining antimicrobial agents, and the focus has now been on natural sources. In this study, Euphorbia milli extract was characterised for antimicrobial activity. The antimicrobial effect was determined by calculating minimum inhibitory concentration against the pathogens Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Streptococcus pneumonia, Klebsiella pneumoniae, and Shigella dysenteriae. The active metabolites of the plant extract manifested a significant antibacterial effect. In silico analysis was carried out using iGemdock as the docking tool for docking Penicillin Binding proteins against the extracted active metabolites. The docking score Hexamethlyl-cyclotrisiloxane / Tolmetin emerged as the most effective active metabolite against all the pathogens except Shigella dysenteriae N-Hexadecanoic acid was the best choice.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.27
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Preservation of Antioxidant Activity and Polyphenols in Mentha spicata L.
           with the Use of Microencapsulation by Calcium Alginate

    • Authors: Ritee Basu, Mitra Lal, S. Govindarajan, Spoorthy N Babu, Ayesha Noor
      Pages: 28 - 37
      Abstract: AbstractNatural polyphenols have scavenging characteristics for radical oxygens species and chelating properties towards proteins. Due to these properties, the polyphenols are used for the treatment of several diseases such as inflammation, cancer or diabetes and are also used additionally in cosmetic formulations and nutraceutical applications. The benefit of encapsulation is less evaporation and degradation of volatile active compounds. It masks unpleasant feelings during eating, such as bitter taste and astringency of polyphenols. However, their limited stability or solubility, often combined with poor bioavailability, have to be resolved to make these compounds more able to answer growing demands in cosmetics, nutrition, and health.We attempted to develop an efficient encapsulation procedure that can enhance the encapsulation amount of polyphenols and in turn, enhance the antioxidant activity of Mentha spicata (Mint or Pudina) for three months at room temperature. Ethanolic extracts containing polyphenols were prepared. Effect of time and temperature on polyphenol release from calcium alginate encapsulated Mentha spicata leaf extract was studied. Results show that calcium alginate influenced microencapsulation efficiency, polyphenol content, and stability. The short-term stability of micro-encapsulated beads was studied for three months. It was observed the polyphenol content and antioxidant activity remained stable in encapsulated beads compared to unencapsulated beads. Thus, Calcium alginate encapsulated beads prove to be a promising technique for food supplements / nutraceuticals.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.28
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Assessment of Seed Germination and Growth of Vigna radiata L in the
           Presence of Green Synthesised and chemically Synthesised Nanoparticles

    • Authors: Anju T R, Parvathy S, Sruthimol S, Jomol J, Mahi M
      Pages: 38 - 46
      Abstract: With the fast developments in nanotechnology, the production of nanomaterials has constantly been expanding, and phytotoxicity by nanoparticles (NPs) is now becoming a major stress factor for plant growth and productivity. Considering the wide applications of NPs in various industries, a feasible way to overcome this stress is to rely on alternative sustainable routes of synthesis. Green nanotechnology is a fast-growing field that offers sustainable options for NP production. In the present study, we targeted the production of silver nanoparticles in a green protocol using the leaf extract of Aloe vera and Rosa indica as an alternative to chemically synthesised AgNP and examined its impact on the growth of seedling and root of a commonly cultivated plant, Vigna radiata L. AgNP formation by green protocol was evident from the colour change of the solution and confirmed by determining the Plasmon resonance peak. The involvement of various phytocomponents in nanoparticle synthesis was identified by Fourier-transform infrared (FTIR) spectroscopy. We identified that chemically synthesised AgNP could create stress in Vigna radiata seeds, thereby inhibiting its germination. The presence of green synthesised AgNPsfrom Aloe vera and Rosa indica showed a germination rate of 88.46 % and86.96 %, respectively. Further observation ofthe root growth parameters have shown that the presence of green synthesised AgNP induced root growth as evident from the increased root length with proper adventitious root formation; indicating an adaptive root development for the plant’s response to its environment, which can be further utilized in nano-agriculture sector for crop improvement.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.29
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Transportation and Removal of E.coli K-12 Through Selenium Doped Zeolite
           Packed bed Reactor

    • Authors: Jayanthi V, Sangeetha Subramanian
      Pages: 47 - 55
      Abstract: At present, water pollution has become a serious threat throughout the world. WHO rec- ommends Escherichia coli as a faecal indicator to analyze the quality of water. This investiga- tion aimed to study the fate and its removal from drinking water and secondary treated wastewa- ter in the zeolite (Z) and selenium doped zeolite composite (Se-Z) packed column system. A se- ries of experiments were carried out to establish the breakthrough curve and to assess the col- umn performance. Breakthrough curve analysis was conducted by varying bed height (2 to 4 cm) and flow rate (1 to 2.5 mL/min) with an initial E. coli concentration of 4 ×1010 mg/L. The remov- al efficiency of Z and Se-Z were compared. In comparison, Se-Z exhibited a higher percentage of E. coli removal of 66.0% for drinking water and 70.18% for secondary treated wastewater.E. coli was efficiently removed by the fixed bed reactor packed with Se-Z with an adsorption ef- ficiency of 14.4*1010 mg/g at bed height of 4 cm with a volumetric flow rate of 1.5 mL/min. The maximum adsorption capacity was obtained with an increased height of the bed and de- creased volumetric flow rate. Selenium doped zeolite packed column exhibited improved elim- ination of E. coli, which can be utilized in the future to treat water-containing pathogenic mi- croorganisms.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.30
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Synergistic Effect of Ocimum sanctum and Piper nigrum: An In Vitro Study
           on Type 2 Diabetes-Related Enzymes and MCF-7 Breast Cancer Cell line

    • Authors: Jayasindu Mathiyazhagan, Harishkumar Madhyastha, E Nalini, K. M. Gothandam
      Pages: 56 - 63
      Abstract: Ocimum sanctum and Piper nigrum are medici- nal plants traditionally used in Ayurveda and oth- er ancient therapeutic systems. Till today people use these plants in one of the different aspects of their everyday life. This study revealed the combined effect of O. sanctum and P. nigrum (1:1) against diabetic-related enzymes in a cell- free system and breast cancer cell line (MCF-7). The HPLC analysis revealed that Eugenol and Piperine are the major phytocompounds in O. sanctum and P. nigrum, respectively. Digestive enzymes like α- amylase and α- glucosidase assays were carried out to find their antidiabet- ic effect. To determine the interaction between Piperine and eugenol with enzymes involved in diabetes, the in silico molecular docking anal- ysis was performed. The plant extracts alone and in combination, were checked for their cy- totoxicity and reactive oxygen species levels in MCF-7 cells.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.31
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Phytochemical Analysis, Antioxidant and Cytotoxicity Activities of In
           Vitro Cultures of Gentiana Kurroo Royle

    • Authors: Mariadoss Alphonse, Kalaivani Thiagarajan
      Pages: 64 - 71
      Abstract: Gentiana kurroo Royle is an endemic plant of the Himalaya and the roots and rhi- zomes of this species possess pharmaceutical- ly important seco-iridoid glucosides. Traditional- ly, wild-grown plants are widely used for various ailments. Therefore, for the first time, the in vi- tro samples like callus, shoot, and adventitious roots of G. kurroo were analyzed for total phe- nolics, flavonoids, antioxidant activity, and cyto- toxicity effect. The antioxidant activity of in vitro G. kurroo cultures was analyzed using different biochemical assays namely, diphenyl-picrylhy- drazyl (DPPH), 2, 2’-azino-bis (3-ethylbenzothi- azoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant potential (FRAP), and total antioxi- dant capacity (TAC). Among the samples test- ed, adventitious roots showed the highest an- tioxidant potential and total phenols (91.2 mg/g DW) and flavonoids (32.43 mg/g DW). The MTT assay showed the IC50 of 550 µg/mL for in vi- tro adventitious root extract on human umbilical cord mesenchymal stem cells (hMSCs). There- fore, the in vitro roots can be used as a viable option to meet its great demand and replace its natural sources.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.32
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Identification of Potential Inhibitors Against Mycobacteriaum tuberculosis
           Protein Targets: An in silico Approach

    • Authors: Nirmaladevi Ponnusamy, Mohanapriya Arumugam
      Pages: 72 - 84
      Abstract: Mycobacterium tuberculosis (Mtb) is gradually gaining resistance to anti-tuberculosis drugs, which have imposed novel drug targets on Mtb for further discovery. Seven proteins involved in the cellular processes of Mtb with their respective PDB IDs, namely rpoC (5UH5), PstS3 (4LVQ), ICDH-1 (4HCX), cpn10 (1P3H),PstS1 (1PC3), PknD (1RWI) and devR/dosR (3C3W), were obtained from the RCSB Pro- tein Data Bank (PDB) and thoroughly analyzed. Literature curated 80 compounds were virtual- ly screened using various bioinformatics tools such as Molinspiration, Osiris Property Explor- er, ProTox-II. Molecular docking interactions of Mtb-Serine/threonine-protein kinase PknD with Alliin ligand shows better binding energy (-6.07 kcal/mol) and the specific key residues such as SER27, GLY28, VAL29, GLN70, GLY71, LEU72, GLU111, GLY112, ASP153, GLY154,GLY196, ILE197, and ALA238 play a vital role in ligand interaction using hydrogen bonds, van der Waals and hydrophobic interaction. Therefore, the finding shows alliin is the ideal phyto-compound that could be used for the op- timized synonymous compound design for safe and efficient tuberculosis treatment specific to the PknD protein target.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.33
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Effect of Synthesized Biopolymer on Physiological and Biochemical Changes
           in Maize Seeds

    • Authors: S. Ponnarmadha
      Pages: 85 - 94
      Abstract: The present study was conducted to check the mixed fruit waste as a substrate for biopolymer production. The hydrolysate obtained after alkali treatment was fermented by a novel strain Enterobacter cloacae and isolated bacterial strain (PS1 & PS2) to produce biopolymer. Ammonuim sulphate (1g/L) was a suitable nitrogen source for biopolymer production among the different nitrogen sources tested. The optimum environmental conditions were: initial pH 7.0, temperature 37 °C, and the C/N ratio was 20:1. Under these controlled conditions, biopolymer yield from Enterobacter cloacae, PS1and PS2 was elevated to 8.4,6.2 and 4.2 g/L, respectively. The FT-IR spectra of biopolymer from Isolate PS1 and PS2 indicate symmetric (O-C-O) presence at 1600cm-1 and asymmetric absorption peak at 1400 cm1. The obtained results suggest that these biopolymers may be similar to PHB. The effect of biopolymer (BP 1) on physiological and biochemical changes in maize seedling growth at different NaCl salt stress concentrations (100, 200 and 300 mM) and Na2CO3 salt stress concentration (25, 50 and 75 mM) were studied. The values of starch content, protein content, alpha-amylase and protease activity were obtained to be higher at 0.4 to 2.4 % concentrations of BP1 when compared to control, Crabshell Extract (CE) and Green Polymer (GP) treatments.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.34
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Isolation, Characterization and in vivo toxicity of Delonix regia Raf.
           Petals on Danio rerio

    • Authors: Hebron Kirubai Raj , Siva Ramamoorthy
      Pages: 95 - 102
      Abstract: Natural pigments and food colorants have shown a positive impact on human health compared to the use of synthetic pigments and colorants. We are reporting the oral toxicity of Delonix regia Raf. It has natural pigments with various pharmaceutical properties. The crude extract was obtained from the D. regia petals and the functional groups in the extract were characterized with UV, FTIR and the compounds were identified using GC-MS. To analyze the toxicity of the crude extract, Zebrafish was used as a model organism. Different concentrations of the extract (5 μg/mL to 2000 μg/mL) were used in the zebrafish embryo. The results revealed that the toxic effect was only seen at higher concentrations (1000 µg/mL and beyond). In lesser concentrations, no toxicity was observed. This preliminary study forms a basis for further animal studies. Also, it adds a new safe food colorant.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.35
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Protective Effect of Non-Selective COX Inhibitor On
           Lipopolysaccharide-Induced Neuroinflammation in Rats Through NF-kB Pathway

    • Authors: Prakash R, Ramanathan M
      Pages: 102 - 110
      Abstract: Inflammations have been implicated in a variety of acute as well as chronic neuro- logic and neurodegenerative disorders. In the current work, we have investigated that selec- tive or non-selective COX inhibitors can reduce the inflammatory response induced by bacte- rial endotoxin Lipopolysaccharide (LPS). Rats were pretreated with COX -1 selective inhibitor (Resveratrol 10 and 20mg/kg), COX-2 inhibitor (Celecoxib 10 and 20mg/kg) or non selective COX inhibitors (Aspirin 10 and 20mg/kg) for 15 days followed by single challenged LPS (100µg/ kg., i.p.). In behavioural tests, pretreated with non-selective COX inhibitors reversed the lo- comotor and exploratory behavior produced by LPS in the open field test and actophotometer. Reverse transcriptase-polymerase chain reac- tion analysis indicated that aspirin significantly attenuates LPS induced upregulated the tumour necrosis factor-α (TNF-α) and inducible nitric ox- ide synthases (iNOS) expression in rat’s brain. In histopathological analysis, aspirin reversed the neuronal damage induced by LPS when compared to selective COX inhibitors. Mecha- nistically, aspirin strongly attenuated the activa- tion of transcription factor nuclear factor kappa B (NF-kB). Having taken the data together, we strongly suggested that a non-selective COX in- hibitor is useful for mitigating neuroinflammatory conditions by block inflammatory cytokines via the nuclear factor kappa B pathway.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.36
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Whole Cells Mediated Biocatalytic Reduction of Alpha- Keto Esters:
           Preparation of Optically Enriched Alkyl 2-hydroxypropanoates

    • Authors: Sowmyalakshmi Venkataraman, Anju Chadha
      Pages: 111 - 122
      Abstract: Biocatalytic reduction of alkyl 2-oxopropanoates were carried out by utilizing the whole cells of Candida parapsilosis ATCC 7330 to form the optically enriched alkyl 2-hydroxypropanoates with good enantiomeric excess (ee) (≤91%) and isolated yields (≤68%). Enantiomerically enriched (S)-ethyl 3-bromo-2- hydroxypropanoate thus synthesized by biocatalytic reduction of ethyl 3-bromo- 2-oxopropanoate is presented in this study for the first time in water under ambient reaction conditions in a reaction time of 4 h which is considerably less than earlier reported procedures.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.37
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Effect of Microencapsulation by Calcium Alginate on the Anti-Oxidant
           Properties of Swietenia macrophylla Polyphenols

    • Authors: Sukanya Dasgupta, Mitra Lal, S Govindarajan, Spoorthy N Babu, Ayesha Noor
      Pages: 123 - 132
      Abstract: Polyphenols are the secondary me- tabolites that possess scavenging properties towards radical oxygen species. Polyphenols have antioxidant properties which are in de- mand because of their therapeutic uses in sev- eral diseases like diabetes, cancer, inflamma- tory, cardiovascular diseases etc. The problem arises with the lack of long-term stability of the polyphenols when exposed to heat and light. It masks the bitter and astringent taste, which limits their use. Nonetheless, the restricted sta- bility and/or solubility needs to be addressed to make these polyphenols capable to answer the increasing demand for food supplements/ Nutraceuticals. We attempted to develop an encapsulation procedure using calcium alginate beads, which retain the anti-oxidant properties and polyphenol content of Swietenia macro- phylla (Sky fruit). Effect of time and tempera- ture on polyphenol release from calcium algi- nate encapsulated Swietenia macrophylla was studied. Results show that the calcium alginate influenced micro-encapsulation efficiency, poly- phenol content and stability. The short-term sta- bility of the microbeads was studied for three months. Due to the excellent polyphenol stabil- ity, the encapsulated beads showed stable an- ti-oxidant activity compared to unencapsulated beads. Thus, the results revealed that calcium alginate beads prove to be a promising tech- nique for food supplements.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.38
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • The Antibacterial and Antibiotic Potentiating Activity of Marine Sponge
           Ircinia fusca Against Fish Pathogens

    • Authors: Teena Terry
      Pages: 133 - 140
      Abstract: Aquaculture is a lucrative industry in severalAsian countries and is a rapidly developing sector in the Indian subcontinent mainly along the coastal regions. The major constraint as well as limiting factor for sustainable fish production is the disease associated with cultured fishes. Hence, it is need of the hour to develop a cost- effective treatment for preventing or controlling disease outbreaks. The marine environment is a rich source that holds a boundless collection of unexplored bioactive compounds. Among the marine populations, sponges remain unique because of the presence of elite bioactive compounds in them. Therefore, in the current study, due emphasis was given to discovering the eco-friendly utilization of marine sponge Ircinia fusca for developing novel bioactive compounds against fish diseases. Antibacterial study of Ircinia fusca was carried out by well diffusion method, minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) against five fish pathogens (Citrobacter freundii, Flavobacterium spp, Aeromonas hydrophila, Vibrio harveyi, and Vibrio parahaemolyticus). Methanolic extract of Ircinia fusca showed potent antibacterial and antibiotic potentiating activity against fish pathogens. The present study reveals that Ircinia fusca is a potent producer of antimicrobial agents which can be developed into a new antibiotic drug. Further research should be done to develop these potential candidates for aquaculture and pharmaceutical sectors in the future.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.39
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • Characterization of Secondary Metabolites Derived from Tomato Endophyte
           – Streptomyces sp. Shanivit

    • Authors: Veilumuthu P, Godwin Christopher J
      Pages: 141 - 152
      Abstract: Endophytic actinomycetes are found in every plant. Actinomycetes are the largest source of antibiotics. The emergence of new diseases has created an urgency of finding new antibiotics that can be used for the treatment, which is the need of the hour. Therefore, we analysed the antimicrobial efficiency of 240 actinomycetes isolates from the Tomato plant Lycopersicon esculin-dem. The actinomycetes isolates were screened for in vitro ability to antagonize selective pathogens such as Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus and Bacillus subtilis. Shanivit showed the highest inhibition compared to other isolates. 16S rRNA gene sequences analysis revealed that Strepto-myces sp. shanivit was 95% similar with Streptomyces mutabilis and Streptomyces rochei species, respectively. Ethyl acetate extract of isolate Streptomyces sp. shanivit showed good antibacterial activity. The GC–MS data showed the presence of 3-Pyrrolidin-2-yl- propionic acid; Oxazolid-2-one, 3-acetyl-4-methyl-5-phenyl-; Fumaric acid, 2-hexyl tetradecyl ester; Bromo- criptine; Cyclohexan,1,3,5-trimethyl-2-octa- decyl-; Ergotaman-3’,6’,18-trione, 9,10-dihydro- 12’-hydroxy; Actinomycin C2 and Didemnin B, and few more compounds. The results of the present study reveal Streptomyces sp. shanivit is an excellent source for antibacterial compounds.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.40
      Issue No: Vol. 16, No. Supplement 1 (2022)
  • An updated Review on Phytochemical and Pharmacological Studies of
           Adenanthera pavonina Linn

    • Authors: Amsaveni Sundarasamy, Thamarai Selvi Senniappan, Suresh Thangaraj
      Pages: 153 - 162
      Abstract: Adenanthera pavonina is a well-known holistic medicinal plant in South Asian countries. Processed seeds of A. pavonina served as a nutrient-rich food. The title plant is used in traditional medicine for the treatment of various diseases such as rheumatism, skin burns and ulcer. Investigations into the pharmacological properties of this plant manifested a wide spectrum of bioactivities including anticancer, anti-malarial, anti-viral activities. Both crude extracts and isolated monomeric compounds exhibit a broad spectrum of pharmacology. Adenovin is a novel peptide isolated from A. pavonina seeds that provide trypsin-inhibition activity. This review aims to highlight the reported phytochemical and pharmacological studies of A. pavonina to explore its pharmaceutical applications.
      PubDate: 2022-06-20
      DOI: 10.5530/ctbp.2022.2s.41
      Issue No: Vol. 16, No. Supplement 1 (2022)
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