Publisher: American Assoc of Immunologists   (Total: 2 journals)   [Sort by number of followers]

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ImmunoHorizons     Open Access  
J. of Immunology     Full-text available via subscription   (Followers: 67, SJR: 2.837, CiteScore: 5)
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Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2573-7732
Published by American Assoc of Immunologists Homepage  [2 journals]
  • Essential Role of RIG-I in Hematopoietic Precursor Emergence in Primitive
           Hematopoiesis during Zebrafish Development

    • Authors: Wang, Y.-y; Nie, L, Xu, X.-x, Shao, T, Fan, D.-d, Lin, A.-f, Xiang, L.-x, Shao, J.-z.
      Pages: 283 - 298
      Abstract: Retinoic acid–inducible gene I (RIG-I) is an important cytosolic pattern recognition receptor crucial for sensing RNA virus infection and initiating innate immune responses. However, the participation of RIG-I in cellular development under physiological conditions remains limited. In this study, the regulatory role of RIG-I in embryonic hematopoiesis was explored in a zebrafish model. Results showed that rig-I was ubiquitously expressed during embryogenesis at 24 h postfertilization (hpf). A defect in RIG-I remarkably disrupted the emergence of primitive hematopoietic precursors and subsequent myeloid and erythroid lineages. In contrast, RIG-I deficiency did not have an influence on the generation of endothelial precursors and angiogenesis and the development of mesoderm and adjacent tissues. The alteration in these phenotypes was confirmed by whole-mount in situ hybridization with lineage-specific markers. In addition, immunostaining and TUNEL assays excluded the abnormal proliferation and apoptosis of hematopoietic precursors in RIG-I–deficient embryos. Mechanistically, RIG-I regulates primitive hematopoiesis through downstream IFN signaling pathways, as shown by the decline in ifn2 and ifn3 expression, along with rig-I knockdown, and rescue of the defects of hematopoietic precursors in RIG-I–defective embryos after administration with ifn2 and ifn3 mRNAs. Additionally, the defects of hematopoietic precursors in RIG-I morphants could be efficiently rescued by the wild-type RIG-I but could not be restored by the RNA-binding–defective RIG-I with site mutations at the RNA-binding pocket, which are essential for association with RNAs. This finding suggested that endogenous RNAs may serve as agonists to activate RIG-I–modulated primitive hematopoiesis. This study revealed the functional diversity of RIG-I under physiological conditions far beyond that previously known.
      PubDate: 2022-05-19T06:42:25-07:00
      DOI: 10.4049/immunohorizons.2200028
      Issue No: Vol. 6, No. 5 (2022)
  • Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA
           and DNA

    • Authors: Lam, L. K. M; Dobkin, J, Eckart, K. A, Gereg, I, DiSalvo, A, Nolder, A, Anis, E, Ellis, J. C, Turner, G, Mangalmurti, N. S.
      Pages: 299 - 306
      Abstract: RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid–sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens of humans are concealed in bats.
      PubDate: 2022-05-20T06:01:29-07:00
      DOI: 10.4049/immunohorizons.2200013
      Issue No: Vol. 6, No. 5 (2022)
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