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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 9)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 5, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 12, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 10)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 2)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 11)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access   (Followers: 1)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 3, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 13)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 3, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 7, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access   (Followers: 1)
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 5, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (Followers: 1, SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 2)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 3)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 2)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 2)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 6)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 11)

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Journal Cover Egyptian Journal of Haematology
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 1110-1067 - ISSN (Online) 2090-9268
   Published by Medknow Publishers Homepage  [355 journals]
  • Hematological changes among children with dengue fever in Saudi Arabia

    • Authors: Marwa H Abdel Hamed
      Pages: 129 - 133
      Abstract: Marwa H Abdel Hamed
      The Egyptian Journal of Haematology 2017 42(4):129-133
      Background Dengue fever is Vector born viral infections endanger billions of people. About 50 million cases of dengue infection every year all-over the whole world has been estimated by World Health Organization (WHO). DF occurs primarily in tropical areas around the world affecting both children and adults. It is endemic in certain cities of Saudi Arabia, such as Jeddah and Makkah. Dengue fever has nonspecific symptoms and signs, so laboratory confirmation of dengue infection is mandatory.Objectives To assess hematological changes of patients with dengue fever in pediatric age group among Saudi children.Design Descriptive retrospective study.Patients and Methods All data were collected from the medical records of 90 children aged from 2 to 15 years who had diagnosed to have dengue fever in Jeddani Group Hospital. The presenting clinical features were collected and analyzed. The laboratory results analyzed were blood count including Hemoglobin level, hematocrit level, lecucocytic count and platelet count.Results All 90 patients included in the study had both fever and myalgia, 2.2% of children had bleeding (epistaxis, bleeding gum). Mean±SD of Hemoglobin level was 10.82 ± 1.2 g/dl. Thrombocytopenia (platelets <150000/UL) was found in 74.45% of cases, leucopenia (<4000/UL) was detected in 66% of cases.Conclusion Dengue fever is mosquito transmitted viral infection, it needs accurate physical examination and proper follows up of hematological changes, this will lead to decrease morbidity and mortality among children.
      Citation: The Egyptian Journal of Haematology 2017 42(4):129-133
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_38_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Programmed death receptor ligand-1 plasma concentration in chronic myeloid
           leukemia under first-line tyrosine kinase inhibitor therapy

    • Authors: Mohamed M Elkhawanky, Amro M El-Ghammaz, Hany M Hegab, Mohamed O El-Mesery
      Pages: 134 - 141
      Abstract: Mohamed M Elkhawanky, Amro M El-Ghammaz, Hany M Hegab, Mohamed O El-Mesery
      The Egyptian Journal of Haematology 2017 42(4):134-141
      Background Chronic myeloid leukemia (CML) cells can suppress the immune system by secreting programmed death receptor ligand-1 (PDL-1) that acts as a coinhibitory molecule for T cells leading to T-cell exhaustion and disease progression.Aim The aim of this study was to assess the plasma level of PDL-1 in patients with chronic myelogenous leukemia and its correlation with prognostic parameters and response to first-line therapy.Patients and methods This study was carried out on 40 patients with CML in chronic phase and 40 control healthy participants. Patients with CML were subdivided into three subgroups, including 11 newly diagnosed patients, 17 imatinib mesylate-responding patients, and 12 imatinib-resistant cases. All patients were subjected to laboratory investigations including complete blood count, peripheral blood smear examination, bone marrow aspiration (if indicated), quantitative real-time PCR for Philadelphia chromosome, and plasma PDL-1 measurement by enzyme-linked immune sorbent assay.Results Our results showed high plasma levels of PDL-1 in patients with CML. Plasma PDL-1 levels showed a negative correlation with total lymphocyte count in imatinib-resistant subgroup. Imatinib-resistant subgroup showed a significant decreased level of PDL-1 versus newly diagnosed subgroup of patients with CML. The suggested PDL-1 cut-off value for prediction of patients with CML was 1327.5 ng/l.Conclusion Patients with chronic-phase CML (newly diagnosed, imatinib responding, and imatinib resistant) showed a highly significant increased PDL-1 level compared with the control group. Increased plasma PDL-1 level is a predictive risk factor for CML incidence and disease progression.
      Citation: The Egyptian Journal of Haematology 2017 42(4):134-141
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_39_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Diagnosis of fungemia among pediatric patients with hematological
           malignancies: value of panfungal polymerase chain reaction

    • Authors: Marwa A El-Ashry, Eman A Ragab
      Pages: 142 - 147
      Abstract: Marwa A El-Ashry, Eman A Ragab
      The Egyptian Journal of Haematology 2017 42(4):142-147
      Introduction Invasive fungal infections (IFIs) remain a significant threat to pediatric patients with hematological malignancies and to those undergoing stem cell transplantation. IFIs not only increase mortality and morbidity but may also lead to delayed administration of chemotherapy, prolonged hospitalization, and additional costs associated with antifungal therapy. Early detection and appropriate treatment is crucial for the survival of these patients.Aim The aim was to determine the value of real-time (RT) PCR, using a panfungal marker, in screening pediatric patients with hematological malignancies for early detection of IFIs.Patients and methods This study included 50 children previously diagnosed with different hematological malignancies and admitted to the Pediatric Hematology, Oncology and Intensive Care Units of Ain Shams University Children Hospital for treatment and follow-up. Children were clinically suspected as having an IFI. There were 20 (40%) females and 30 (60%) males, with their ages ranging from 2 to 18 years (median: 6; interquartile range: 4–10.25). Venous blood was collected from all patients and was submitted for the diagnosis of IFI by conventional blood culture and RT-PCR assay using universal fungal primers for amplification of the internal transcribed spacer 1 and internal transcribed spacer 4 regions.Results Of the 50 studied cases, 40% were positive for IFI by both blood culture and the panfungal PCR. A total of 12 (24%) patients were positive by the panfungal PCR only and the remaining 36% were negative by both assays. There was a statistically moderate agreement between the results of blood culture and that of RT-PCR for the detection of the panfungal marker (κ=0.545).Conclusion RT-PCR assay, using the panfungal marker, is a rapid and sensitive assay that can be reliably used for screening hematological malignant patients at high risk of IFIs. The negative predictive value of the assay is 100%; thus, it can provide greater confidence in excluding a diagnosis of IFIs when negative results are obtained. This, in turn, can help prevent unnecessary toxicity resulting from empirical antifungal treatment in individuals who may not be at risk of imminent fungal disease. However, the RT-PCR for the detection of the panfungal marker lacks specificity, making the interpretation of positive results a challenge.
      Citation: The Egyptian Journal of Haematology 2017 42(4):142-147
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_41_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Role of measurement of interleukin 10 in idiopathic (immune)
           thrombocytopenic purpura

    • Authors: Hanan Hamed, Mohamed Moussa, Hanaa Fathey, Heba Tolba
      Pages: 148 - 154
      Abstract: Hanan Hamed, Mohamed Moussa, Hanaa Fathey, Heba Tolba
      The Egyptian Journal of Haematology 2017 42(4):148-154
      Aim Biological markers useful for defining newly diagnosed patient with immune thrombocytopenic purpura (ITP) who are likely to develop the chronic form of the disease are partially lacking. The purpose of this study was to assess the clinical role of a cytokine in patients with ITP and correlate its levels with different stages of the disease.Patients and methods A total of 20 patients with ITP at the onset stage, 40 patients with chronic ITP, and 30 healthy matched controls were enrolled in this study. Serum levels of interleukin 10 (IL-10) were measured in all patients using quantitative immunoenzymatic assays.Result Serum IL-10 levels were significantly higher in patients with an acute evolution of ITP than in either healthy controls or patients with chronic ITP.Conclusion IL-10 seems to predict the clinical course of ITP, as it is significantly higher at the onset of the disease in patients who obtain disease remission in less than 1 year.
      Citation: The Egyptian Journal of Haematology 2017 42(4):148-154
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_26_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Can CD34/CD123 distinguish between normal and leukemic B-cell
           precursors?

    • Authors: Saad S Esh, Nashwa M Al Azizi, Usama R Elsafy, Laila M Sherief, Marwa Zakaria, Marwa M Abdalah
      Pages: 155 - 160
      Abstract: Saad S Esh, Nashwa M Al Azizi, Usama R Elsafy, Laila M Sherief, Marwa Zakaria, Marwa M Abdalah
      The Egyptian Journal of Haematology 2017 42(4):155-160
      Background/objective B-cell acute lymphoblastic leukemia (B-ALL) is the most common acute leukemia in children. There are many overlaps between leukemic lymphoblast and hematogones regarding their morphologic and immunophenotypic characteristics. CD123 is one of the markers that can be used to distinguish between leukemic lymphoblast and hematogones. In this study, we aimed to demonstrate the pattern of CD34/CD123 expression in hematogones and leukemic lymphoblast to monitor therapy response and detect minimal residual disease.Patients and methods This case–control study was conducted on 40 newly diagnosed patients with B-lineage ALL. They were 14 boys and 26 girls with a mean age of 4.29±2.31 and a range from 2 to 10 years. Expression of CD34/CD123 by flow cytometry was carried out at diagnosis and at the end of induction. In addition, 20 patients with reactive bone marrow were included to asses hematogones.Results In the patient group, cells with dim CD45 were found in 24 cases, 75% of them expressed CD34 and 83.3% expressed CD123. In addition, cells with moderate CD45 were 16, all expressed CD34 and 87.5% of them expressed CD123. Thirty-two (80%) leukemic blasts expressed both CD34 and CD123; in contrast, in four (10%) patients neither antigen was expressed. In hematogones, immature hematogones (dim CD45, CD34+) did not express CD123, whereas 75% of mature hematogones (moderate CD45, CD34−) expressed CD123. On the other hand, at the end of induction, 18 (45%) leukemic blasts expressed both CD34 and CD123 and four (10%) showed no expression of both antigens.Conclusion This distinct pattern of CD34 and CD123 expression on B-ALL blasts (concordant) and hematogones (discordant) can help differentiate residual leukemic blasts from hematogones in patients with B-ALL.
      Citation: The Egyptian Journal of Haematology 2017 42(4):155-160
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_10_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Phenotype analysis of lymphocytes in workers with chronic benzene exposure

    • Authors: Hanan M Fayed, Sanaa S Aly, Samira M Saleh, Mohamed El-Shahat Ebeid, Yasser A Ahmed
      Pages: 161 - 168
      Abstract: Hanan M Fayed, Sanaa S Aly, Samira M Saleh, Mohamed El-Shahat Ebeid, Yasser A Ahmed
      The Egyptian Journal of Haematology 2017 42(4):161-168
      Background Automobile service station workers are at high risk of benzene toxicity because they neither take protective measures to prevent inhalation of petroleum products nor undergo regular medical checkup.Objective The aim of this paper was to study the effects of long-term benzene exposure on blood cells and liver function.Patients and methods The study was a controlled trial, which included 30 automobile service station workers investigated for alterations in blood cells, hepatic functions, and lymphocyte phenotype.Results When compared with controls, benzene-exposed workers had significant increase in alanine aminotransferase (47.80±3.19 vs. 28.50±4.35), aspartate aminotransferase (41.20±2.62 vs. 23.60±4.58), and alkaline phosphatase (305.13± 16.39 vs. 174.40±26.69) levels and significant decrease in total proteins (6.39±0.11 vs. 6.79±0.12), albumin (3.57±0.14 vs. 4.5±0.48), hemoglobin (10.77±0.49 vs. 13.97±0.69), platelets count (146.8±4.9 vs. 217.8±37.4), mean platelet volume (7.68±0.4; 8.83±0.8), white blood cells (3459±444 vs. 6171±1482), monocytes (188±64 vs. 338±190), neutrophils (2095±267 vs. 3487±998), lymphocytes (1177±265 vs. 2138±439) and its subsets [CD3 cells (948±217 vs. 1686±337), CD4 cells (321±81 vs. 1101±222), B cells (228±70 vs. 45.1±13.22), and CD4 : CD8 ratio (0.51±0.04 vs. 1.88±0.08)], with significant increase in CD8 cells (627±138 vs. 585±117) and platelet-lymphocyte ratio (PLR) (130.7±26.66 vs. 104.96±22.49).The duration of exposure positively correlated with PLR and negatively correlated with hemoglobin, platelets, mean platelet volume, white blood cells, neutrophil, lymphocyte (B cells, helper cells, and suppressor cells), and serum albumin. PLR had a negative correlation with CD4, CD8, and CD19 absolute counts.Conclusion Benzene exposure is detrimental to the liver and bone marrow and results in the reduction of all blood and lymphocyte series, intiating immune suppression which may predispose to carcinogenesis. PLR is a valuable, inexpensive, and reproducible index that is closely associated with impaired immune system in benzene-exposed workers.
      Citation: The Egyptian Journal of Haematology 2017 42(4):161-168
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/1110-1067.225090
      Issue No: Vol. 42, No. 4 (2018)
       
  • Acquired angioedema in a chronic lymphocytic leukemia patient in
           remission: a case report

    • Authors: Nahla Osman, Eman A Tawfik
      Pages: 169 - 171
      Abstract: Nahla Osman, Eman A Tawfik
      The Egyptian Journal of Haematology 2017 42(4):169-171
      Acquired angioedema is a rare but a well-recognized complication of lymphoproliferative disorders. It occurs as a result of overactivation of the compliment system due to reduced C1 esterase inhibitors with subsequent release of bradykinin.A 59-year-old gentleman with chronic lymphocytic leukemia experienced recurrent episodes of angioedema while on chemotherapy. Investigations confirmed low C1 inhibitor activity in a few occasions. Acute episodes were treated with replacement therapy. Chemotherapy was stopped after cycle 4 as remission was achieved. He experienced a further episode of clinically more severe acquired angioedema after stopping chemotherapy. He was treated with C1 inhibitor concentrate in the high-dependency unit. Subsequently, antifibrinolytics were started as long-term prophylaxis. He had no recurrence of angioedema since then.Conclusion High clinical suspicion and early diagnosis of this rare complication of chronic lymphocytic leukemia is crucial for reducing the morbidity and mortality in these patients. Although treatment directed to the underlying condition is beneficial in most cases with angioedema, this is not invariable and chemotherapy cannot be justified for those who are in remission.
      Citation: The Egyptian Journal of Haematology 2017 42(4):169-171
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_5_17
      Issue No: Vol. 42, No. 4 (2018)
       
  • Isolated trisomy 6 cytogenetic abnormalities in acute myeloid leukaemia: a
           case report

    • Authors: Vikranth Varma, Anil Aribandi, Sushma Chelmeda
      Pages: 172 - 174
      Abstract: Vikranth Varma, Anil Aribandi, Sushma Chelmeda
      The Egyptian Journal of Haematology 2017 42(4):172-174

      Citation: The Egyptian Journal of Haematology 2017 42(4):172-174
      PubDate: Fri,9 Feb 2018
      DOI: 10.4103/ejh.ejh_33_17
      Issue No: Vol. 42, No. 4 (2018)
       
 
 
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