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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 8)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 6)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access   (Followers: 2)
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 8)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 3)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
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J. of Digestive Endoscopy     Open Access   (Followers: 3)
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Journal Cover Egyptian Pharmaceutical Journal
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   ISSN (Print) 1687-4315 - ISSN (Online) 2090-9853
   Published by Medknow Publishers Homepage  [355 journals]
  • Synthesis and antimicrobial activity of substituted
           1,4-bis-spiro[benzocycloheptene-6(5h),3′(3h-pyrazol)-5-one]-benzene
           under microwave irradiation and molecular docking study

    • Authors: Fatma A.A. El-Hag, Ahmed A Elrashedy
      Pages: 71 - 77
      Abstract: Fatma A.A. El-Hag, Ahmed A Elrashedy
      Egyptian Pharmaceutical Journal 2017 16(2):71-77
      Background and objective Spiropyrazole derivatives are one of the most bioactive spiro compounds that play a vital role in drug discovery, such as antibacterial, anti-inflammatory, antifungal, antiviral, analgesic, and antidepressant activities. Moreover, microwave as an energy source enhances the reaction rates and improves the regioselectivity. The aim of this study was to synthesize the spiropyrazole derivative compounds. Molecular docking was performed.Materials and methods 1,3-Dipolar cycloaddition of 6,6′-(1,4-phenylene-bis(methanylylidene))-bis(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one) to a variety of nitrilimines (generated in situ by triethylamine dehydrohalogenation of the corresponding hydrazonoyl halides) under microwave irradiation proceeded regioselectively affording spiro[benzo[7]-annulene-6,3′-pyrazol]-4′-yl)phenyl)-spiro[benzo[7]annulene-6,3′-pyrazol]-5(7H)-ones. The structure of the newly synthesized compounds was confirmed on the basis of spectral data and elemental analyses. The antimicrobial activity of the bis(spiropyrazoles) derivatives was tested for antimicrobial activity. Molecular docking was performed and analyzed with the molecular modeling environment program.Results and conclusion Compound 7f has high potency against all fungi (except Candida albicans) and bacterium species (except Pseudomonas aeruginosa) compared with the reference drug fungicide amphotericin B and the standard bactericides ampicillin and gentamicin. Docking of the most active antibacterial compounds 7f and 7g against the dihydropteroate synthase enzyme gave comparable scores for hydrogen bond interaction (−22.9123, −17.5995 kcal/mol(and binding mode to the reference antibiotic sulfamethoxazole (−13.00 kcal/mol).
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):71-77
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/1687-4315.214206
      Issue No: Vol. 16, No. 2 (2017)
       
  • Modulation effects of quercetin against copper oxide nanoparticles-induced
           liver toxicity in rats

    • Authors: Azza F Arafa, Hassan Z Ghanem, Mahmoud S Soliman, Emad EL-Meligy
      Pages: 78 - 86
      Abstract: Azza F Arafa, Hassan Z Ghanem, Mahmoud S Soliman, Emad EL-Meligy
      Egyptian Pharmaceutical Journal 2017 16(2):78-86
      Background and objectives Despite the several benefits of nanotechnology, studies indicated that certain nanoparticles (NPs) may cause adverse effects because of their minute size and unique properties. The aim of this study is to investigate the role of quercetin (que) in attenuating toxicity by copper oxide (CuO) NPs in rat liver.Materials and methods The effect of CuO-NPs on the liver was induced by two injections of CuO-NPs (size >20 nm) at the dose 3 mg/kg and 50 mg/kg intraperitoneally in different groups of female rats for 7 days. The effects of NPs were tested by evaluating liver function enzymes: alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase; antioxidant biomarkers: nitric oxide, catalase activity, reduced glutathione, and total antioxidant capacity; DNA damage as shown by comet assay; and histopathological examination of hepatic tissue. Flavonoids que was administered orally to intoxicated rats at the dose of 200 mg/kg for 30 consecutive days.Results and conclusion The present results indicated significant depletion in serum hepatic enzyme activities and improvement in the cellular antioxidant status of CuO-NPs-intoxicated rats after administration of que. Histopathological examination of hepatic tissue treated with que confirmed the previous biochemical results, which showed normal architecture of hepatic tissues. However, treatment of intoxicated rats with que led to a significant reduction in the DNA damage, tail length, and tail moment. Oxidative stress could be considered to play a key role in liver toxicity by CuO-NPs. This research also showed that que is an effective free-radical quencher and could represent a potential valid therapeutic for hepatotoxicity.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):78-86
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_15_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Phytochemical and genotoxicity studies of Citrus reticulata aerial part in
           mice

    • Authors: Amal Z Hassan, Khadiga M Ahmed, Nagat S Abu-Gabal, Karima F Mahrous, Nagwa M.M. Shalaby
      Pages: 87 - 97
      Abstract: Amal Z Hassan, Khadiga M Ahmed, Nagat S Abu-Gabal, Karima F Mahrous, Nagwa M.M. Shalaby
      Egyptian Pharmaceutical Journal 2017 16(2):87-97
      Background and objectives The genus Citrus (family Rutaceae) is known to contain many bioactive compounds like flavonoids that protect mice against genotoxicity because of their antioxidant and free radical scavenging properties. The aim of this study was to investigate the phytochemical constituents and the protective effect of the ethanolic extract of the aerial part of Citrus reticulata cultivated in Saudi Arabia against genotoxicity induced by benzo(a)pyrene (BaP) in mice.Materials and methods The major constituents from of the aerial part of C. reticulata were isolated using different chromatographic techniques. Identification of compounds was realized through Rf values, shift reagents, and spectroscopic tools such as ultraviolet and nuclear magnetic resonance. The constituents of both unsaponifiable and methylated fatty acids were identified using Gas Liquid Chromatography (GLC) analysis. Essential oil constituents of peels and aerial part of C. reticulata were obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry. PBS, 1% LMPA, and ethidium bromide were used for the comet assay and quantitative analysis of DNA fragmentation in liver tissue in male rats was determined. About 50 male mice were used in this study, which were allocated in five groups (10 animals each) and treated with BaP and C. reticulata [total ethanolic extract (TE) and petroleum ether fraction].Results and conclusion Phytochemical investigation of the ethanolic extract from the aerial part of C. reticulata revealed five flavonoids (1–5). GLC analysis of the unsaponifiable fraction showed the presence of α-tocotrienol and α-tocopherol, which belong to the group of vitamin E. A total of 22 compounds were identified in the essential oils of C. reticulata blanco, 12 compounds were found in the aerial part, and 12 compounds were found in the fruit peels. The ethanolic extract was tested for the first time against genotoxicity induced by BaP in mice using the comet assay. TE significantly reduced the damage of DNA caused by BaP in mice. There was a statistically significant increase (P≤0.05) in the DNA fragmentation in the liver tissues of male mice and an increased rate of DNA damage in mice blood cells in the BaP group. Treatment with TE has a significant liver and blood cell protection by inhibiting the rate of DNA damage. These findings led us to conclude that the aerial part of C. reticulata is useful to reduce the genotoxicity induced by hazardous chemical agents.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):87-97
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_13_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Microwave-assisted extraction as an alternative tool for extraction of
           Stachys aegyptiaca essential oil

    • Authors: Alaa M Shaheen, Ibrahim A Saleh, El-Sayeda A El-Kashoury, Wafaa A Tawfik, Elsayed A Omar, Mohamed-Elamir F Hegazy, Essam Abdel-Sattar
      Pages: 98 - 102
      Abstract: Alaa M Shaheen, Ibrahim A Saleh, El-Sayeda A El-Kashoury, Wafaa A Tawfik, Elsayed A Omar, Mohamed-Elamir F Hegazy, Essam Abdel-Sattar
      Egyptian Pharmaceutical Journal 2017 16(2):98-102
      Background and objectives Stachys aegyptiaca Pers. (family Lamiaceae) is a perennial aromatic wild plant collected from Saint Catherine Protectorate, Sinai. The essential oil of S. aegyptiaca was obtained using two different techniques, conventional hydrodistillation (HD) and microwave-assisted extraction (MAE). The aim of the present study was to compare the effect of the two techniques on oil yield and oil composition. MAE offered reduction in the extraction time with better oil yield compared with HD.Materials and methods Two different techniques, conventional HD and MAE, were used for the extraction of essential oil from S. aegyptiaca. The chemical composition of the essential oil was analyzed using the gas chromatography–mass spectrometry technique.Results and conclusion Gas chromatography–mass spectrometry of the essential oils obtained revealed the presence of 48 and 30 components constituting 99.31 and 99.82% of the total composition of the oils obtained using; MAE and HD, respectively. Variations in the percentage yield and chemical composition were observed. The major component found in the extracted oils was α-pinene (24.65% HD and 41.14% MAE). MAE offered reduction in the extraction time (60 min vs. 3 h) with better oil yield (1.4% w/v) when compared with HD (0.9% w/v). MAE could be used as an alternative tool for the isolation of essential oils from their natural sources.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):98-102
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_11_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Harpullia pendula Planch leaves: phenolics, in vitro antioxidant and
           α-amylase inhibitory activity

    • Authors: Sahar S.M. El Souda, Reda S Mohammed, Faten M Ibrahim, Azza A Matloub
      Pages: 103 - 111
      Abstract: Sahar S.M. El Souda, Reda S Mohammed, Faten M Ibrahim, Azza A Matloub
      Egyptian Pharmaceutical Journal 2017 16(2):103-111
      Background and objective Harpullia pendula Planch leaves belong to the Sapindaceae family. The study aimed to investigate the phenolic constituents and evaluate the antioxidant and α-amylase inhibitory activities of the plant’s extracts and its major compounds.Materials and methods The compounds were isolated through chromatographic techniques from the defatted ethanolic extract (DAEE). Their structures were determined by ultraviolet, mass spectrometer, and nuclear magnetic resonance spectroscopy.Results The flavonoids kaempferol 3-O-(6″galloyl)- apiofuranosyl (1‴→2″)-β-galactopyranoside, kaempferol-3-O-β-glucopyranosyl(1‴→6″)-β-glucopyranoside, kaempferol 3-O-(6″galloyl)-apiofuranosyl (1‴→2″)-β-galactopyranoside, rutin, vitexin, isovitexin, orientin, quercetin, kaempferol; the tannins ellagic acid, gallic acid, methyl gallate, 2,6-di-O-galloyl(α/β)glucoside, 2,3-di-O-galloyl(α/β)glucoside, and tetragalloyl glucoside in addition to two benzene acetic acid derivatives, harpulliaside A and cavaol B, were isolated from the total bioactive ethanolic extract (TEE). The TEE and the DAEE of H. pendula have a total phenolic content of 255.5±7.18 and 222.9±6.43 mg gallic acid equivalents/g extract, respectively, and a total flavonoid content of 111.6±3.2 and 102.6±2.6 mg quercetin equivalents/g extract, respectively. With respect to the in vitro study, DAEE, TEE, and methyl gallate showed an interesting inhibitory activity on 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) [half maximal inhibitory concentration (IC50): 13.3±0.4, 17.7±0.7, and 19.4±0.08 µg/ml, respectively], nitric oxide (IC50: 12.8±2.54, 18.3±1.6, and 29.8±1.00 µg/ml, respectively), and α-amylase (IC50: 6.1±0.554, 14.4±0.681, and17.5±0.003 µg/ml, respectively).Conclusion H. pendula extracts are rich in phenolic compounds; the aforementioned results suggest that DAEE, TEE, and methyl gallate may be potentially useful in hegemony of obesity and diabetes.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):103-111
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_10_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Liquisolid compacts of meloxicam: in-vitro and in-vivo evaluation

    • Authors: Remeth J Dias, Shashi Ranjan, Kailas K Mali, Vishwajeet S Ghorpade, Vijay D Havaldar
      Pages: 112 - 120
      Abstract: Remeth J Dias, Shashi Ranjan, Kailas K Mali, Vishwajeet S Ghorpade, Vijay D Havaldar
      Egyptian Pharmaceutical Journal 2017 16(2):112-120
      Background Meloxicam (MXM) is a poorly soluble drug and its low aqueous solubility leads to poor dissolution and bioavailability.Aim The aim of this study was to investigate the potential of a liquisolid system to improve the dissolution rate and the bioavailability of MXM.Materials and methods The liquisolid compacts were prepared using Avicel PH102 as a carrier material, Aerosil 200 as a coating material, Polyethylene glycol 400 as a liquid vehicle, and sodium starch glycolate as a superdisintegrating agent. The 15 liquisolid compact formulations were prepared by varying drug concentrations in the liquid vehicle. Attenuated total reflectance Fourier transform infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffraction were used to investigate the physicochemical interaction and crystallinity of the drug in the liquisolid compact. MXM compacts were evaluated for uniformity of drug content, tablet hardness, friability, disintegration, and dissolution. An in-vivo study was carried out in male albino rats. The data were presented as mean±SD and were compared using the one-way ANOVA. A P-value less than 0.05 were considered to be significant.Results The liquisolid system of MXM was formulated successfully using Avicel PH102, Aerosil 200, and Polyethylene glycol 200. The results of attenuated total reflectance Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction study indicated the existence of hydrogen bonding between drug and excipients and the complete amorphization of MXM. In-vitro evaluation parameters for the liquisolid compact were found to be within the acceptable limits. It was found that optimized liquisolid tablet formulation showed higher dissolution than the marketed tablet, with more than 80% drug release within 10 min. The pharmacokinetic data showed a higher bioavailability of liquisolid compact of MXM compared with the marketed product.Conclusion The liquisolid compact can be a promising alternative for the formulation of water-insoluble drug MXM with improved dissolution and bioavailability.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):112-120
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_9_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Comparative evaluation of coprecipitation, solvent evaporation, and
           kneading as techniques to improve solubility and dissolution profiles of a
           BCS class IV drug

    • Authors: Ebere I Okoye, Chizoba G Ezenwa, Ome I Aburime, Austinline C Ekweogu
      Pages: 121 - 130
      Abstract: Ebere I Okoye, Chizoba G Ezenwa, Ome I Aburime, Austinline C Ekweogu
      Egyptian Pharmaceutical Journal 2017 16(2):121-130
      Purpose Furosemide bioavailability is limited by poor solubility and permeability. This study aimed to compare coprecipitation, kneading, and solvent evaporation as solubility and dissolution improvement techniques.Materials and methods Products were prepared with furosemide : polyvinylpyrrolidone : lactose at 1 : 1 : 2, 1 : 2 : 3, 1 : 3 : 4, 1 : 1 : 4, 1 : 2 : 6, 1 : 3 : 8 by coprecipitation, kneading, solvent evaporation or physical blending. They were characterized for physicochemical properties and interaction. Solubilities of furosemide from products were evaluated in water and n-octanol. Dissolution studies on the products were conducted in 0.1 N HCl using USP apparatus II.Results Solubility of pure furosemide was lowest in n-octanol (11.86 μg/ml) and highest in PBS (28.68 μg/ml). Infrared spectra revealed that characteristic peaks in pure furosemide were retained in its formulations, indicating chemical compatibility of furosemide and the excipients. Differential scanning calorimetry thermogram of furosemide showed a melting point at 220°C, which disappeared in its formulations − attributable to amorphization of the drug or overshadow by excipients. Furosemide significantly partitioned more (P<0.05) into water than into n-octanol. Batch 1 : 3 : 4 formulations gave the best partitioning of drug into the solvents, and was in the following order: solvent evaporation>kneading>physical mixtures>coprecipitation. Cumulative amount of furosemide dissolved from pure sample was 8%, whereas amounts from formulations were significantly higher (P<0.05). Coprecipitation products displayed the poorest profiles, kneading gave better profiles, but lagged behind solvent evaporation, whose products’ dissolution profiles were significantly better (P<0.05) than other products studied.Conclusion All the methods improved the solubilities and dissolution profiles of furosemide to various degrees; however, solvent evaporation method was the best.
      Citation: Egyptian Pharmaceutical Journal 2017 16(2):121-130
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_7_17
      Issue No: Vol. 16, No. 2 (2017)
       
  • Erratum: Assessment of some synthesized novel 9-substituted
           tetrahydroacridine derivatives in diabetic disease management in rats

    • Pages: 131 - 131
      Abstract:
      Egyptian Pharmaceutical Journal 2017 16(2):131-131

      Citation: Egyptian Pharmaceutical Journal 2017 16(2):131-131
      PubDate: Fri,8 Sep 2017
      DOI: 10.4103/epj.epj_27_17
      Issue No: Vol. 16, No. 2 (2017)
       
 
 
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