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Publisher: Medknow Publishers   (Total: 429 journals)

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Showing 1 - 200 of 429 Journals sorted alphabetically
Acta Medica Intl.     Open Access   (SJR: 0.101, CiteScore: 0)
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advanced Biomedical Research     Open Access  
Advances in Human Biology     Open Access   (Followers: 3)
Advances in Skeletal Muscle Function Assessment     Open Access  
African J. for Infertility and Assisted Conception     Open Access  
African J. of Medical and Health Sciences     Open Access   (Followers: 2)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.25, CiteScore: 1)
African J. of Trauma     Open Access   (Followers: 1)
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Alexandria J. of Pediatrics     Open Access  
Ancient Science of Life     Open Access   (Followers: 5)
Anesthesia : Essays and Researches     Open Access   (Followers: 10)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.258, CiteScore: 1)
Annals of Bioanthropology     Open Access   (Followers: 4)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 14, SJR: 0.308, CiteScore: 1)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Annals of Indian Academy of Otorhinolaryngology Head and Neck Surgery     Open Access  
Annals of Indian Psychiatry     Open Access  
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.352, CiteScore: 1)
Annals of Saudi Medicine     Open Access   (SJR: 0.238, CiteScore: 1)
Annals of Thoracic Medicine     Open Access   (Followers: 5, SJR: 0.524, CiteScore: 1)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 12, SJR: 0.152, CiteScore: 0)
Annals of Tropical Pathology     Open Access  
Apollo Medicine     Open Access  
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Cardiovascular Imaging     Open Access   (Followers: 1, SJR: 0.187, CiteScore: 0)
Archives of Intl. Surgery     Open Access   (Followers: 10, SJR: 0.302, CiteScore: 1)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Medicine and Surgery     Open Access  
Archives of Pharmacy Practice     Open Access   (Followers: 6, SJR: 0.102, CiteScore: 0)
Archives of Trauma Research     Open Access   (Followers: 3, SJR: 0.37, CiteScore: 2)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 4)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.856, CiteScore: 2)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 1, SJR: 0.35, CiteScore: 1)
Asian Pacific J. of Reproduction     Open Access   (SJR: 0.227, CiteScore: 1)
Asian Pacific J. of Tropical Biomedicine     Open Access   (Followers: 2, SJR: 0.491, CiteScore: 2)
Asian Pacific J. of Tropical Medicine     Open Access   (Followers: 1, SJR: 0.561, CiteScore: 2)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
Biomedical and Biotechnology Research J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Canadian J. of Rural Medicine     Full-text available via subscription   (SJR: 0.202, CiteScore: 0)
Cancer Translational Medicine     Open Access   (Followers: 2)
Cardiology Plus     Open Access  
Chinese Medical J.     Open Access   (Followers: 10, SJR: 0.52, CiteScore: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Cancer Investigation J.     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 2)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 10, SJR: 0.811, CiteScore: 2)
Contemporary Clinical Dentistry     Open Access   (Followers: 4, SJR: 0.353, CiteScore: 1)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.543, CiteScore: 1)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.152, CiteScore: 0)
Dental Research J.     Open Access   (Followers: 11, SJR: 0.416, CiteScore: 1)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 6, SJR: 0.242, CiteScore: 0)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1, SJR: 1.799, CiteScore: 2)
Egyptian J. of Chest Diseases and Tuberculosis     Open Access   (Followers: 3, SJR: 0.155, CiteScore: 0)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access   (Followers: 1)
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.127, CiteScore: 0)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 2)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Nursing J.     Open Access  
Egyptian Orthopaedic J.     Open Access   (Followers: 2)
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.822, CiteScore: 2)
Environmental Disease     Open Access   (Followers: 2)
Eurasian J. of Pulmonology     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.749, CiteScore: 2)
European J. of General Dentistry     Open Access   (Followers: 1, SJR: 0.12, CiteScore: 0)
European J. of Prosthodontics     Open Access   (Followers: 3)
European J. of Psychology and Educational Studies     Open Access   (Followers: 11, SJR: 0.113, CiteScore: 0)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.112, CiteScore: 0)
Genome Integrity     Open Access   (Followers: 3, SJR: 0.153, CiteScore: 0)
Glioma     Open Access  
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Gynecology and Minimally Invasive Therapy     Open Access   (SJR: 0.311, CiteScore: 1)
Hamdan Medical J.     Open Access  
Heart and Mind     Open Access  
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
Ibnosina J. of Medicine and Biomedical Sciences     Open Access  
IJS Short Reports     Open Access  
Imam J. of Applied Sciences     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.478, CiteScore: 1)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (Followers: 1, SJR: 0.361, CiteScore: 1)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.37, CiteScore: 1)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.604, CiteScore: 1)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.266, CiteScore: 1)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.468, CiteScore: 1)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 5, SJR: 0.445, CiteScore: 1)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1, SJR: 0.791, CiteScore: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4, SJR: 0.568, CiteScore: 1)
Indian J. of Health Sciences     Open Access   (Followers: 3)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.425, CiteScore: 1)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.503, CiteScore: 1)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.656, CiteScore: 1)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.102, CiteScore: 0)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 2, SJR: 0.347, CiteScore: 1)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.23, CiteScore: 0)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 3, SJR: 0.225, CiteScore: 1)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.498, CiteScore: 1)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 8, SJR: 0.392, CiteScore: 1)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.199, CiteScore: 0)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.454, CiteScore: 1)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 2, SJR: 0.276, CiteScore: 1)
Indian J. of Pharmacology     Open Access   (SJR: 0.412, CiteScore: 1)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.311, CiteScore: 0)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.408, CiteScore: 1)
Indian J. of Psychological Medicine     Open Access   (SJR: 0.368, CiteScore: 1)
Indian J. of Public Health     Open Access   (Followers: 1)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Respiratory Care     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.119, CiteScore: 0)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.34, CiteScore: 0)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Transplantation     Open Access  
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.434, CiteScore: 1)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Indian Spine J.     Open Access  
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intervention     Open Access   (Followers: 1)
Intl. Archives of Health Sciences     Open Access  
Intl. J. of Abdominal Wall and Hernia Surgery     Open Access  
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Clinicopathological Correlation     Open Access  
Intl. J. of Community Dentistry     Open Access  
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1, SJR: 0.192, CiteScore: 0)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 4)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 3, SJR: 0.142, CiteScore: 0)
Intl. J. of Growth Factors and Stem Cells in Dentistry     Open Access  
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 6)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.535, CiteScore: 1)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4, SJR: 0.17, CiteScore: 0)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 2)
Intl. J. of Orofacial Biology     Open Access  
Intl. J. of Orofacial Research     Open Access  
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.623, CiteScore: 1)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 5, SJR: 0.653, CiteScore: 1)
Intl. J. of the Cardiovascular Academy     Open Access   (SJR: 0.105, CiteScore: 0)
Intl. J. of Trichology     Open Access   (SJR: 0.4, CiteScore: 1)
Intl. J. of Yoga     Open Access   (Followers: 13)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 5)

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Journal Cover
Indian Journal of Medical Research
Journal Prestige (SJR): 0.656
Citation Impact (citeScore): 1
Number of Followers: 4  

  This is an Open Access Journal Open Access journal
ISSN (Print) 0971-5916
Published by Medknow Publishers Homepage  [429 journals]
  • Ending tuberculosis in India: A political challenge & an opportunity

    • Authors: Hannah Monica Yesudian Dias, Madhukar Pai, Mario C Raviglione
      Pages: 217 - 220
      Abstract: Hannah Monica Yesudian Dias, Madhukar Pai, Mario C Raviglione
      Indian Journal of Medical Research 2018 147(3):217-220

      Citation: Indian Journal of Medical Research 2018 147(3):217-220
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_660_18
      Issue No: Vol. 147, No. 3 (2018)
       
  • Pandemic Flu, 1918: After hundred years, India is as vulnerable

    • Authors: Lalit Kant, Randeep Guleria
      Pages: 221 - 224
      Abstract: Lalit Kant, Randeep Guleria
      Indian Journal of Medical Research 2018 147(3):221-224

      Citation: Indian Journal of Medical Research 2018 147(3):221-224
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_407_18
      Issue No: Vol. 147, No. 3 (2018)
       
  • Role of apoptotic markers in paediatric acute lymphoblastic leukaemia

    • Authors: Gauri Kapoor, Neha Singh
      Pages: 225 - 227
      Abstract: Gauri Kapoor, Neha Singh
      Indian Journal of Medical Research 2018 147(3):225-227

      Citation: Indian Journal of Medical Research 2018 147(3):225-227
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_906_17
      Issue No: Vol. 147, No. 3 (2018)
       
  • Universal health coverage framework to combat antimicrobial resistance

    • Authors: Rajesh Bhatia
      Pages: 228 - 232
      Abstract: Rajesh Bhatia
      Indian Journal of Medical Research 2018 147(3):228-232

      Citation: Indian Journal of Medical Research 2018 147(3):228-232
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1462_17
      Issue No: Vol. 147, No. 3 (2018)
       
  • Host-targeted therapy for tuberculosis: Time to revisit the concept

    • Authors: Prabha Desikan, Aseem Rangnekar
      Pages: 233 - 238
      Abstract: Prabha Desikan, Aseem Rangnekar
      Indian Journal of Medical Research 2018 147(3):233-238
      Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Every year millions of people die due to TB. Drug resistance has been a major factor that has obstructed successful control and treatment of TB. As the rate of spread of drug-resistant TB outpaces the rate of discovery of new anti-tubercular drugs, targeted therapy may provide a new approach to TB cure. In a scenario where drug resistance is spreading rapidly, and existing drugs regimens seem to be dwindling away, this review summarizes the concept of host-targeted therapy which may be the ray of hope for the effective management and control of the rapidly spreading drug-resistant TB (multidrug resistant and extensively drug resistant).
      Citation: Indian Journal of Medical Research 2018 147(3):233-238
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_652_17
      Issue No: Vol. 147, No. 3 (2018)
       
  • Genotypes of erythrovirus B19, their geographical distribution &
           circulation in cases with various clinical manifestations

    • Authors: Amita Jain, Ravi Kant
      Pages: 239 - 247
      Abstract: Amita Jain, Ravi Kant
      Indian Journal of Medical Research 2018 147(3):239-247
      Erythrovirus B19 (B19V) is one of the erythroviruses known to be pathogenic in humans. B19V is classified into three distinct genotypes; 1, 2 and 3, differing from each other by 2-13 per cent. Genotype 1 consists of the prototype B19V isolates, genotype 2 comprises the A6, LaLi and their related isolates while genotype 3 includes the V9- and V9-related isolates. The classification of genotype 1 into two subtypes (1A and 1B) and genotype 3 into two subtypes (3a and 3b) with an estimated nucleotide difference of about 5 per cent has been done. Predominance of genotype 1 across all the continents is seen followed by genotypes 2 and 3. There are no disease-specific genotypes. All the three genotypes have been found in symptomatic as well as asymptomatic individuals and have been reported from several countries across the world. The prevalence of genotype 2 in older populations and its absence from current circulation in Northern Europe has also been reported. The present review focuses on geographic distribution and association of genotypes of B19V with different clinical manifestations.
      Citation: Indian Journal of Medical Research 2018 147(3):239-247
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1816_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Low spontaneous apoptosis index at diagnosis predicts a high-risk
           phenotype in paediatric acute lymphoblastic leukaemia

    • Authors: Ankita Singh, Prateek Bhatia, Amita Trehan, Deepak Bansal, Ajit Singh, Alka Bhatia
      Pages: 248 - 255
      Abstract: Ankita Singh, Prateek Bhatia, Amita Trehan, Deepak Bansal, Ajit Singh, Alka Bhatia
      Indian Journal of Medical Research 2018 147(3):248-255
      Background & objectives: Significance of apoptosis as a prognostic marker is less well studied in paediatric acute lymphoblastic leukaemia (ALL) cases. Hence, a prospective study, involving 30 paediatric ALL cases, was done to assess the clinical relevance of in vivo apoptosis.Methods: Peripheral blood mononuclear cells from all patients were subjected to annexin V/propidium iodide staining to detect the degree of apoptosis [apoptotic index (AI)] at day 0 and day 35 post-induction chemotherapy. In addition, Bax and Bcl2 apoptotic protein expressions were studied at day 0 and their relative fluorescence mean intensity (RFMI) ratios were calculated.Results: Mean age of patients was 5.1 years. Of the 30 cases, 21 (70%) were at standard-risk, five (17%) at intermediate and four (13%) at high risk. Majority (83%) were B-ALL. Day 8 absolute blast count was >1000/μl in seven (23%) and <1000/μl in 23 of 30 (77%) cases. Day 35 marrow was M1 in 23 (92%) and M2 in two of 25 (8%) cases. AI at day 0 and day 35 ranged from 0.9 to16.6 per cent and 1.4 to 62.8 per cent with a mean of 5.90 and 19.64 per cent, respectively. The Bax/Bcl2 ratio ranged from 0.2 to 3.5 with a mean of 0.83. The ratio was predominantly anti-apoptotic, i.e. <1 (77%). A significant association was noted between low AI at day 0 and high total leucocyte count (P=0.02), T-cell phenotype (P=0.043) and high-risk as per NCI category (P=0.025). Significant increase (>30%) in day 35 AI was seen in only six cases.Interpretation & conclusions: Our study showed that low AI at day 0 was associated with a high-risk clinical phenotype in paediatric ALL. However, studies on larger group, especially with longer follow up or study of relapse cases, will help draw conclusions regarding apoptosis assessment in paediatric ALL.
      Citation: Indian Journal of Medical Research 2018 147(3):248-255
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_303_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Whole-body 18F-fluorodeoxyglucose positron emission tomography-computed
           tomography (18F-FDG PET/CT) for staging locally advanced breast cancer: A
           prospective study from a tertiary cancer centre in south India

    • Authors: Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
      Pages: 256 - 262
      Abstract: Sivanath Reddy Gajjala, Narendra Hulikal, Silpa Kadiyala, Radhika Kottu, Tekchand Kalawat
      Indian Journal of Medical Research 2018 147(3):256-262
      Background & objectives: Locally advanced breast cancer (LABC) is associated with substantial risk of occult metastases. The patients with LABC have high rate of systemic relapse, suggesting inadequacy of the current conventional staging in detecting the occult metastatic spread. 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) is a new modality in the staging of breast cancer patients. Hence, this study was conducted to evaluate the role of 18F-FDG PET/CT in initial staging of LABC and to compare it with conventional methods.Methods: This prospective study included biopsy-confirmed female patients diagnosed with LABC meeting the selection criteria and attending surgical, medical and radiation oncology departments of a tertiary care centre in south India, from April 2013 to December 2014. Conventional workup included serum chemistry, mammogram, bone scan, contrast-enhanced CT (CECT) chest and upper abdomen and ultrasound abdomen and pelvis. All patients following conventional workup underwent 18F-FDG PET/CT.Results: In this study, 61 women with LABC underwent both conventional workup and 18F-FGD PET/CT. The 18F-FDG PET/CT, in comparison to conventional workup, revealed unsuspected N3 nodal disease in 11 more patients, revealed distant metastasis in seven more patients and also detected extra sites of metastasis in five patients. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT to detect distant metastasis were 95, 98, 95, 98 and 97 per cent, respectively, whereas the sensitivity, specificity, positive predictive value, negative predictive value and accuracy of conventional imaging to detect distant metastasis were 65, 93, 81, 84 and 84 per cent, respectively.Interpretation & conclusions: The 18F-FDG PET/CT was found to be more accurate than conventional imaging for staging and modified stage and treatment in 30 and 38 per cent of patients, respectively. It was particularly useful in detecting occult distant metastasis and N3 nodal disease with an added advantage of examining whole body in single session. However, CECT chest was superior over 18F-FDG PET/CT for detecting pulmonary metastasis.
      Citation: Indian Journal of Medical Research 2018 147(3):256-262
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1368_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Comparative study between liquid-based cytology & conventional Pap smear
           for cytological follow up of treated patients of cancer cervix

    • Authors: Uma Singh, Anjum, Sabuhi Qureshi, Neha Negi, Nisha Singh, Madhumati Goel, Kirti Srivastava
      Pages: 263 - 267
      Abstract: Uma Singh, Anjum, Sabuhi Qureshi, Neha Negi, Nisha Singh, Madhumati Goel, Kirti Srivastava
      Indian Journal of Medical Research 2018 147(3):263-267
      Background & objectives: Cancer cervix is one of the most common forms of genital malignancy among Indian women. Recurrence is seen in a significant number of cases. The conventional cervical smear technique has inherent problems and screening and interpretation errors. This study was undertaken to assess the efficacy of liquid-based cytology (LBC) as a method for cytological follow up and detection of recurrence in treated cases of cancer cervix and to compare it with conventional Pap smear technique to find the best screening method for detection of recurrence in these patients.Methods: This cross-sectional study was conducted over a period of one year. Patients attending Gynecology and Radiotherapy outpatient departments for follow up after treatment of cancer cervix were included. Pap smear and LBC were taken in all cases. Colposcopy and biopsy were done for those having epithelial cell abnormality in cytology report. Colposcopy and biopsy were taken as gold standard for diagnosis of cancer cervix recurrence.Results: Ninety four treated patients of carcinoma cervix were studied. The diagnostic accuracy for detection of recurrence of conventional Pap smear was 79.16 per cent, and that of LBC was 97.6 per cent. The difference between the two methods was significant (P<0.001).Interpretation & conclusions: Our findings showed that LBC performed better than the conventional method of cytology to detect recurrence of squamous cell carcinoma. Its sensitivity, specificity as well as accuracy were much higher than conventional method. LBC can be a better method of cytological follow up of post-treated patients of cancer cervix.
      Citation: Indian Journal of Medical Research 2018 147(3):263-267
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_854_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Time trends in prevalence of anaemia in pregnancy

    • Authors: K Kalaivani, Prema Ramachandran
      Pages: 268 - 277
      Abstract: K Kalaivani, Prema Ramachandran
      Indian Journal of Medical Research 2018 147(3):268-277
      Background & objectives: The prevalence of anaemia in pregnancy in India is among the highest in the world. In the last two decades, several national surveys have estimated haemoglobin levels in pregnant women. In this study, data from these surveys were analyzed to find out changes, if any, in prevalence of anaemia in pregnancy.Methods: National and State-level estimates on the prevalence of anaemia were tabulated from the reports of the National Family Health Survey (NFHS) 2, NFHS 3, Fact Sheets of NFHS 4 and District Level Household Survey (DLHS) 2. Unit level data from DLHS 4 and Annual Health Survey Clinical Anthropometric and Biochemical component (AHS CAB) were obtained and State level prevalence of different grades of anaemia was estimated. Time trends in the prevalence of anaemia and different grades of anaemia were assessed from these surveys.Results: NFHS 2, 3 and 4 reported relatively lower prevalence of anaemia as compared to DLHS and AHS CAB. There was not much change in the prevalence or severity of anaemia between NFHS 2, 3 and 4. There was substantial reduction in the prevalence and severity of anaemia in all States except Uttarakhand between DLHS 2 and 4 and DLHS 2 and AHS CAB.Interpretation & conclusions: There was a reduction in the prevalence and severity of anaemia in the last 15 years. The two-pronged strategy of increasing iron intake (dietary diversification and use of iron-fortified iodized salt) in all the population and testing, and detecting and treating pregnant women with anaemia will accelerate the pace of reduction in anaemia.
      Citation: Indian Journal of Medical Research 2018 147(3):268-277
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1730_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Genetic diversity of Mycobacterium tuberculosis in south coastal
           Karnataka, India, using spoligotyping

    • Authors: Kiran Chawla, Ajay Kumar, Vishnu Prasad Shenoy, Devendra Singh Chauhan, Pragya Sharma
      Pages: 278 - 286
      Abstract: Kiran Chawla, Ajay Kumar, Vishnu Prasad Shenoy, Devendra Singh Chauhan, Pragya Sharma
      Indian Journal of Medical Research 2018 147(3):278-286
      Background & objectives: Despite high occurrence of tuberculosis in India very little information is available about the genetic diversity of Mycobacterium tuberculosis isolates prevailing in coastal Karnataka, India. Thus, the present study was undertaken to explore the genetic biodiversity of M. tuberculosis isolates prevailing in south coastal region of Karnataka (Udupi District), India.Methods: A total of 111 Mycobacterial isolates were cultured in Lowenstein Jensen (LJ) medium and after obtaining growth, DNA was extracted and spoligotyping was performed. SITVIT WEB database was used to locate families of spoligotypes.Results: On analyzing the hybridization results of all 111 isolates on SITVIT WEB database 57 (51.35%) isolates were clustered into 11 Spoligotype International Types (SIT). The largest cluster of 14 (12.61%) isolates was SIT-48 (EAI1-SOM), followed by SIT-1942 (CAS1-Delhi) with 11 isolates (9.9%) and SIT-11 with seven (6.30%). Moreover, 23 isolates (20.72%) had unique spoligotypes and 31 (27.92%) were orphans. Spotclust analysis revealed that majority (67%) of orphan isolates were variants of CAS (37%) and EAI-5 (34%). Interpretation & conclusions: The present study revealed high biodiversity among the circulating isolates of M. tuberculosis in this region with the presence of mixed genotypes earlier reported from north and south India along with certain new genotypes with unique SITs. The study highlights the need for further longitudinal studies to explore the genetic diversity and to understand the transmission dynamics of prevailing isolates.
      Citation: Indian Journal of Medical Research 2018 147(3):278-286
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_2026_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Intrapatient variability in plasma rifampicin & isoniazid in
           tuberculosis patients

    • Authors: A. K. Hemanth Kumar, V Chandrasekaran, T Kannan, J Lavanya, Soumya Swaminathan, Geetha Ramachandran
      Pages: 287 - 292
      Abstract: A. K. Hemanth Kumar, V Chandrasekaran, T Kannan, J Lavanya, Soumya Swaminathan, Geetha Ramachandran
      Indian Journal of Medical Research 2018 147(3):287-292
      Background & objectives: Large variability in anti-tuberculosis (TB) drug concentrations between patients is known to exist. However, limited information is available on intrapatient drug levels during the course of anti-TB treatment (ATT). This study was conducted to evaluate intrapatient variability in plasma rifampicin (RMP) and isoniazid (INH) concentrations during ATT at start of the treatment, at the end of intensive phase (IP) of ATT and at the end of ATT in adult TB patients being treated in the Revised National TB Control Programme (RNTCP).Methods: Adult TB patients (n=485), receiving thrice-weekly ATT in the RNTCP, were studied. Two-hour post-dosing concentrations of RMP and INH were determined at month 1, end of IP and end of ATT, after directly observed drug administration. Drug concentrations were estimated by high-performance liquid chromatography.Results: The median (inter-quartile range) RMP concentrations during the first month, at end of IP and end of ATT were 2.1 (0.4-5.0), 2.4 (0.6-5.5) and 2.2 (0.5-5.3) μg/ml, respectively. The corresponding INH concentrations were 7.1 (4.2-9.9), 7.2 (3.9-10.9) and 6.7 (3.9-9.5) μg/ml. None of the differences in drug concentrations obtained at different time points during ATT were significant. RMP and INH concentrations at different time points were significantly correlated. Age and body mass index caused significant variability in drug concentrations.Interpretation & conclusions: Plasma RMP and INH estimations in adult TB patients at two hours after drug administration remained unaltered during ATT. Clinicians can consider testing drug concentrations at any time point during ATT. These findings may assume significance in the context of therapeutic drug monitoring of anti-TB drug concentrations.
      Citation: Indian Journal of Medical Research 2018 147(3):287-292
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1961_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Evaluation of real-time reverse-transcription loop-mediated isothermal
           

    • Authors: Jyoti S Kumar, Divyasha Saxena, Manmohan Parida, Sivakumar Rathinam
      Pages: 293 - 298
      Abstract: Jyoti S Kumar, Divyasha Saxena, Manmohan Parida, Sivakumar Rathinam
      Indian Journal of Medical Research 2018 147(3):293-298
      Background & objectives: West Nile virus (WNV) is a mosquito-borne flavivirus. The disease can be diagnosed by isolation followed by fluorescent antibody tests, enzyme-linked immunosorbent assay and polymerase chain reaction (PCR) assay. These diagnostic methods are laborious and time-consuming. The present study was aimed to evaluate the real-time reverse-transcription loop-mediated isothermal amplification (RT-LAMP) method for rapid, early and accurate diagnosis of WNV.Methods: A one-step single tube accelerated quantitative RT-LAMP assay was evaluated by targeting the Env gene of WNV. The gene amplification was accomplished by incubating the reaction mixture at 63°C for 60 min in both real time turbidimeter as well as routine laboratory water bath/dry heating bath. To rule out contamination issues, proper negative controls, including no template, no primer; and no enzyme, were always kept alongside each run. The RT-LAMP assay was evaluated on 105 clinical samples from individuals having ocular infection.Results: Of the 105 samples tested, 27 were positive for WNV by RT-LAMP assay. The comparative evaluation with conventional RT-PCR revealed 100 per cent accordance with sensitivity and specificity of 100 and 95 per cent, respectively. The specificity of this assay was confirmed with serum samples obtained from patients with dengue and chikungunya.Interpretation & conclusions: The RT-LAMP test seemed to be a sensitive and specific method for rapid detection of WNV infection and would be useful for rapid screening of a large number of clinical samples in endemic areas during outbreaks.
      Citation: Indian Journal of Medical Research 2018 147(3):293-298
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/0971-5916.234607
      Issue No: Vol. 147, No. 3 (2018)
       
  • Field testing & evaluation of the efficacy & duration of effectiveness of
           a biolarvicide, Bactivec® SC (Bacillus thuringiensis var. israelensis
           SH-14) in Bengaluru, India

    • Authors: Sreehari Uragayala, Raghavendra Kamaraju, Satyanarayan Tiwari, Susanta Kumar Ghosh, Neena Valecha
      Pages: 299 - 307
      Abstract: Sreehari Uragayala, Raghavendra Kamaraju, Satyanarayan Tiwari, Susanta Kumar Ghosh, Neena Valecha
      Indian Journal of Medical Research 2018 147(3):299-307
      Background & objectives: Different formulations of Bacillus thuringiensis var. israelensis (Bti) have been tested against different mosquito vectors and other insects for their residual activity. In the present study, the efficacy and residual activity of a new formulation of Bti (Bactivec Suspension Concentrate) were evaluated against immature stages of Anopheles stephensi Liston (Diptera: Culicidae), Aedes aegypti Linnaeus (Diptera: Culicidae) and Culex quinquefasciatus Say (Diptera: Culicidae), in natural habitats in Phase II and Phase III in Bengaluru, India.Methods: Preferential breeding habitats of the mosquito species were selected and four dosages (0.25, 0.5, 1 and 2 ml/50 l) were tested in Phase II trial. Two most effective dosages, 0.5 and 1 ml/50 l were selected for Phase III trial. The evaluation was carried out essentially following the guidelines of the World Health Organization Pesticide Evaluation Scheme. Pre-treatment and post-treatment densities were recorded at regular intervals, and >80 per cent reduction in pupae was taken as the duration of effectiveness.Results: Bactivec SC treated at the dosage of 1 ml/50 l could produce 10-17 days efficacy (>80% reduction in pupae) in clean water habitats tested, whereas 0.5 ml/50 l dosage showed residual activity from 7 to 14 days against Ae. aegypti and An. stephensi in Phase III studies. In polluted water habitats, 4-7 days efficacy could be recorded against Cx. quinquefasciatus in Phase III.Interpretation & conclusions: The Bactivec SC formulation was operationally feasible and easy to handle. For the control of Anopheles and Aedes mosquitoes in freshwater habitats, 1 ml/50 l dosage was found effective, whereas in polluted water habitats against Cx. quinquefasciatus 5 ml/m2 was found effective.
      Citation: Indian Journal of Medical Research 2018 147(3):299-307
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1631_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Years of potential life lost due to cancer in Kamrup Urban District of
           Assam, northeast India

    • Authors: Jagannath Dev Sharma, Amal Chandra Kataki, Manoj Kalita
      Pages: 308 - 311
      Abstract: Jagannath Dev Sharma, Amal Chandra Kataki, Manoj Kalita
      Indian Journal of Medical Research 2018 147(3):308-311

      Citation: Indian Journal of Medical Research 2018 147(3):308-311
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1505_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Creation of monosodium iodoacetate-induced model of osteoarthritis in
           rabbit knee joint

    • Authors: Elizabeth Vinod, P. R. J. V. C. Boopalan, Sabareeswaran Arumugam, Solomon Sathishkumar
      Pages: 312 - 314
      Abstract: Elizabeth Vinod, P. R. J. V. C. Boopalan, Sabareeswaran Arumugam, Solomon Sathishkumar
      Indian Journal of Medical Research 2018 147(3):312-314

      Citation: Indian Journal of Medical Research 2018 147(3):312-314
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_2004_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • A possible need for routine screening for Strongyloides stercoralis
           infection in Indian haemophilia patients

    • Authors: Rucha K Patil, Kanjaksha K Ghosh, S Chandrakala, Shrimati Shetty
      Pages: 315 - 317
      Abstract: Rucha K Patil, Kanjaksha K Ghosh, S Chandrakala, Shrimati Shetty
      Indian Journal of Medical Research 2018 147(3):315-317

      Citation: Indian Journal of Medical Research 2018 147(3):315-317
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1236_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Circulation of Nipah virus in Pteropus giganteus bats in northeast region
           of India, 2015

    • Authors: Pragya Yadav, Anakkathil Sudeep, Mangesh Gokhale, Shailesh Pawar, Anita Shete, Deepak Patil, Vimal Kumar, Rajen Lakra, Prasad Sarkale, Stuart Nichol, Devendra Mourya
      Pages: 318 - 320
      Abstract: Pragya Yadav, Anakkathil Sudeep, Mangesh Gokhale, Shailesh Pawar, Anita Shete, Deepak Patil, Vimal Kumar, Rajen Lakra, Prasad Sarkale, Stuart Nichol, Devendra Mourya
      Indian Journal of Medical Research 2018 147(3):318-320

      Citation: Indian Journal of Medical Research 2018 147(3):318-320
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_1488_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • An unusual cause of dysphagia in a child: Gastrointestinal manifestations
           of epidermolysis bullosa

    • Authors: Raghu Prakash, Archana Puri
      Pages: 321 - 321
      Abstract: Raghu Prakash, Archana Puri
      Indian Journal of Medical Research 2018 147(3):321-321

      Citation: Indian Journal of Medical Research 2018 147(3):321-321
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_793_16
      Issue No: Vol. 147, No. 3 (2018)
       
  • Dermatitis neglecta

    • Authors: Sonali Langar, Sidharth Sonthalia
      Pages: 322 - 322
      Abstract: Sonali Langar, Sidharth Sonthalia
      Indian Journal of Medical Research 2018 147(3):322-322

      Citation: Indian Journal of Medical Research 2018 147(3):322-322
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_43_17
      Issue No: Vol. 147, No. 3 (2018)
       
  • Imaging in endocrine disorders

    • Authors: AK Gupta, D Kandasamy
      Pages: 323 - 324
      Abstract: AK Gupta, D Kandasamy
      Indian Journal of Medical Research 2018 147(3):323-324

      Citation: Indian Journal of Medical Research 2018 147(3):323-324
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/0971-5916.234617
      Issue No: Vol. 147, No. 3 (2018)
       
  • Practical use of biostatistics: For medical, allied sciences &
           research professional

    • Authors: DK Subbakrishna
      Pages: 324 - 324
      Abstract: DK Subbakrishna
      Indian Journal of Medical Research 2018 147(3):324-324

      Citation: Indian Journal of Medical Research 2018 147(3):324-324
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/0971-5916.234618
      Issue No: Vol. 147, No. 3 (2018)
       
  • The right therapy for neurological disorders: From randomized trials to
           clinical practice

    • Authors: M.V. Padma Srivastava
      Pages: 324 - 326
      Abstract: M.V. Padma Srivastava
      Indian Journal of Medical Research 2018 147(3):324-326

      Citation: Indian Journal of Medical Research 2018 147(3):324-326
      PubDate: Mon,18 Jun 2018
      DOI: 10.4103/ijmr.IJMR_70_17
      Issue No: Vol. 147, No. 3 (2018)
       
 
 
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