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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 7)
African J. of Medical and Health Sciences     Open Access   (Followers: 1)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 12, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 5)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access   (Followers: 1)
Bulletin of Faculty of Physical Therapy     Open Access  
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access  
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 11, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access  
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 4, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access  
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access  
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 6)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 7, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access  
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 4, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 3)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 2)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 2)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 6, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 1)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access  
J. of Family Medicine and Primary Care     Open Access   (Followers: 8)

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Journal Cover Indian Journal of Endocrinology and Metabolism
  [4 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2230-8210 - ISSN (Online) 2230-9500
   Published by Medknow Publishers Homepage  [355 journals]
  • Technosocial competence in diabetology

    • Authors: Sanjay Kalra, Karthik Balachandran
      Pages: 489 - 491
      Abstract: Sanjay Kalra, Karthik Balachandran
      Indian Journal of Endocrinology and Metabolism 2017 21(4):489-491

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):489-491
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_155_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Thyroid vigilance

    • Authors: Sanjay Kalra, Deepak Khandelwal, Sameer Aggarwal
      Pages: 492 - 494
      Abstract: Sanjay Kalra, Deepak Khandelwal, Sameer Aggarwal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):492-494

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):492-494
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_104_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Diabetes care: Evolution of philosophy

    • Authors: Sanjay Kalra, Manash P Baruah, Bharti Kalra
      Pages: 495 - 497
      Abstract: Sanjay Kalra, Manash P Baruah, Bharti Kalra
      Indian Journal of Endocrinology and Metabolism 2017 21(4):495-497

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):495-497
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_109_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • A prospective study on role of supplemental oral calcium and Vitamin D in
           prevention of postthyroidectomy hypocalcemia

    • Authors: Krishnan Ravikumar, Dhalapathy Sadacharan, Sankaran Muthukumar, Thalavai Sundarram, Selladurai Periyasamy, RV Suresh
      Pages: 498 - 503
      Abstract: Krishnan Ravikumar, Dhalapathy Sadacharan, Sankaran Muthukumar, Thalavai Sundarram, Selladurai Periyasamy, RV Suresh
      Indian Journal of Endocrinology and Metabolism 2017 21(4):498-503
      Background: Postoperative transient hypocalcemia is sequelae of total thyroidectomy (TT), which is observed in up to 50% of patients. Routine oral calcium and Vitamin D supplementation have been proposed to prevent symptomatic hypocalcemia preventing morbidity and facilitating early discharge. Patients and Methods: A total of 208 patients with nontoxic benign thyroid disorders, undergoing TT, were serially randomized into four groups: Group A (no supplements were given), Group B (oral calcium - 2 g/day given), Group C (calcium and calcitriol - 1 mcg/day are given), and Group D (calcium, calcitriol, and cholecalciferol - 60,000 IU/day are given). Patients were monitored for clinical and biochemical hypocalcemia (serum calcium, [Sr. Ca] <8 mg/dl), along with serum intact parathormone (Sr. PTH) and magnesium 6 h after surgery and Sr. Ca every 24 h. Intravenous (IV) calcium infusion was started, if any of the above four groups exhibit frank hypocalcemia. Patients are followed up with Sr. Ca and Sr. PTH at 3 and 6 months. Results: All groups were age and sex matched. Hypocalcemia was observed in 72/208 (34.61%) cases. Incidence of hypocalcemia was higher in Group A (57.69%) and Group B (50%) compared to Group C (15.38%) and Group D (15.38%). Hypocalcemia necessitating IV calcium occurred in 31/208 (14.90%) patients. IV calcium requirement exceeded in Group A (26.92%) and Group B (23.07%) compared to Group C (5.76%) and Group D (3.84%). There was no statistical difference in basal levels of serum Vitamin D, calcium, magnesium, intact PTH, and 6 h after surgery. Permanent hypoparathyroidism developed in five patients on follow-up. Conclusion: Routine postoperative supplementation of oral calcium and Vitamin D will help in the prevention of postthyroidectomy transient hypocalcemia significantly. Preoperative Vitamin D levels do not predict postoperative hypocalcemia.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):498-503
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_402_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Myopathy in patients taking atorvastatin: A pilot study

    • Authors: K Manoj, N Jain, SV Madhu
      Pages: 504 - 509
      Abstract: K Manoj, N Jain, SV Madhu
      Indian Journal of Endocrinology and Metabolism 2017 21(4):504-509
      Aim: This study aims to investigate the prevalence and risk factors of statin-induced myopathy. Subjects and Methods: A total of 200 patients aged ≥ 40 years and taking atorvastatin 10 mg/day or more for at least 2 weeks were recruited in the study. A detailed history of participants and anthropometry of study participants was recorded, and features of myopathy were explained. Biochemical investigations along with thyroid stimulating hormone (TSH) and Vitamin D were done in all patients. Results: Mean age of study population was 54.81 ± 9.10 years. Sixty-five percent (65.5%) of atorvastatin users had coronary heart disease, 62.5% were hypertensive, 38% had diabetes. Thirty-five percent (35.5%) patients were taking 10 mg/day atorvastatin, 45% were taking 20 mg/day, and 19.5% were taking 40 mg/day. The overall frequency of myopathy among statin users was 7.5% which was significantly higher with increasing dose of atorvastatin (1.4% in 10 mg/day group, 10% in 20 mg/day group, and 12.8% in 40 mg/day, P< 0.05). The frequency of atorvastatin-related myopathy was higher in females 8.65% compared to 6.25% in males. Serum TSH levels in patients with myopathy were 4.05 ± 7.76 μIU/ml while in those without myopathy were 3.13 ± 2.88 μIU/ml (P = 0.649). Serum 25-hydroxy Vitamin D levels were measured in 66 patients randomly. Mean levels in patients with myopathy were 15.98 ± 12.94 ng/ml and without myopathy were 10.20 ± 5.64 ng/ml (P = 0.285). Conclusion: The present study demonstrates that a significantly higher number of patients taking atorvastatin develop myopathy in real life clinical condition. The frequency of myopathy increases with increase in atorvastatin dose.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):504-509
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_79_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • High prevalence of serine protease inhibitor Kazal type 1 gene variations
           detected by whole gene sequencing in patients with fibrocalculous
           pancreatic diabetes

    • Authors: Anish Kolly, C Shivaprasad, Annie A Pulikkal, Sridevi Atluri, Vijaya Sarathi, CS Dwarakanath
      Pages: 510 - 514
      Abstract: Anish Kolly, C Shivaprasad, Annie A Pulikkal, Sridevi Atluri, Vijaya Sarathi, CS Dwarakanath
      Indian Journal of Endocrinology and Metabolism 2017 21(4):510-514
      Aim of Study: The aim is to study the prevalence and pattern of serine protease inhibitor Kazal type 1 (SPINK1) gene variations in patients with fibrocalculous pancreatic diabetes (FCPD) using whole gene sequencing. Materials and Methods: A total of 56 consecutive patients of FCPD were recruited for the study. Diagnosis of FCPD was based on the presence of diabetes mellitus in patients having chronic pancreatitis with radiological evidence of ductal calcifications, in the absence of other known causes for pancreatitis. Ethylenediaminetetraacetic acid samples were collected from all patients, and complete gene sequencing was performed for SPINK1 gene using Sanger technique. Results: Overall 35 patients (62.5%) were detected to have genetic alterations in SPINK1 gene. N34S polymorphism was seen in 23 participants (41.07%) out of which 3 were homozygous. N34S was seen to be in linkage disequilibrium with IVS1 − 37T>C (18/23) and IVS3-69insAAAA (19/23) polymorphisms. Seven patients (12.5%) had a 272 C>T 3'UTR polymorphism while one patient (1.8%) had a P55S polymorphism. Two patients (3.5%) had an IVS3 + 2T>C mutation which has been shown to be associated with loss of function of SPINK protein. Overall 48.2% of FCPD patients had genetic variations that were significant compared to the control population. There was no difference in anthropometric and biochemical parameters between those with or without SPINK1 gene variations. Conclusions: Variations in SPINK1 gene are frequently observed in FCPD. N34S polymorphism was the most common variation followed by intronic variations. Two patients had the pathogenic intronic IVS3 + 2T>C mutation. Whole gene sequencing of the SPINK1 gene enabled detection of an additional 7.1% of patients with significant SPINK1 gene variations as compared to targeted screening for the N34S variation.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):510-514
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_116_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Are predictive equations for estimating resting energy expenditure
           accurate in Asian Indian male weightlifters?

    • Authors: Mini Joseph, Riddhi Das Gupta, L Prema, Mercy Inbakumari, Nihal Thomas
      Pages: 515 - 519
      Abstract: Mini Joseph, Riddhi Das Gupta, L Prema, Mercy Inbakumari, Nihal Thomas
      Indian Journal of Endocrinology and Metabolism 2017 21(4):515-519
      Background: The accuracy of existing predictive equations to determine the resting energy expenditure (REE) of professional weightlifters remains scarcely studied. Our study aimed at assessing the REE of male Asian Indian weightlifters with indirect calorimetry and to compare the measured REE (mREE) with published equations. A new equation using potential anthropometric variables to predict REE was also evaluated. Materials and Methods: REE was measured on 30 male professional weightlifters aged between 17 and 28 years using indirect calorimetry and compared with the eight formulas predicted by Harris–Benedicts, Mifflin-St. Jeor, FAO/WHO/UNU, ICMR, Cunninghams, Owen, Katch-McArdle, and Nelson. Pearson correlation coefficient, intraclass correlation coefficient, and multiple linear regression analysis were carried out to study the agreement between the different methods, association with anthropometric variables, and to formulate a new prediction equation for this population. Results: Pearson correlation coefficients between mREE and the anthropometric variables showed positive significance with suprailiac skinfold thickness, lean body mass (LBM), waist circumference, hip circumference, bone mineral mass, and body mass. All eight predictive equations underestimated the REE of the weightlifters when compared with the mREE. The highest mean difference was 636 kcal/day (Owen, 1986) and the lowest difference was 375 kcal/day (Cunninghams, 1980). Multiple linear regression done stepwise showed that LBM was the only significant determinant of REE in this group of sportspersons. A new equation using LBM as the independent variable for calculating REE was computed. REE for weightlifters = −164.065 + 0.039 (LBM) (confidence interval −1122.984, 794.854]. This new equation reduced the mean difference with mREE by 2.36 + 369.15 kcal/day (standard error = 67.40). Conclusion: The significant finding of this study was that all the prediction equations underestimated the REE. The LBM was the sole determinant of REE in this population. In the absence of indirect calorimetry, the REE equation developed by us using LBM is a better predictor for calculating REE of professional male weightlifters of this region.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):515-519
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_563_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Mutational analysis of androgen receptor gene in two families with
           androgen insensitivity

    • Authors: Radha Ramadevi Akella
      Pages: 520 - 523
      Abstract: Radha Ramadevi Akella
      Indian Journal of Endocrinology and Metabolism 2017 21(4):520-523
      Background: Androgen insensitivity syndrome (AIS) is a rare X-linked disorder due to mutations in the androgen receptor (AR) gene causing end-organ resistance to the androgenic hormone. Subjects and Methods: Genetic studies were carried out in two families by karyotype and targeted exome sequencing of the AR gene. Results: Two novel missense mutations were identified, p.L822P and p.P392S, in two families with complete androgen insensitivity (CAIS) and partial androgen insensitivity (PAIS), respectively. Both had 46, XY karyotype. The mother was a heterozygous carrier in PAIS and negative in CAIS. These two were novel mutations, reported for the first time, in the AR gene. In silico analysis predicted that both mutations were damaging. We reviewed the various reported Indian mutations in the AR gene. Conclusion: AR gene mutations cause a wide spectrum of disorders from CAIS to male infertility or primary amenorrhea. Early diagnosis is essential for gender assignment and further management, family counseling, and prenatal diagnosis.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):520-523
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_345_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • The effect of yoga and peer support interventions on the quality of life
           of women with diabetes: Results of a randomized controlled trial

    • Authors: Aswathy Sreedevi, Ambika Gopalakrishnan Unnikrishnan, Sundaram Ramaiyer Karimassery, Kuttikattu Soman Deepak
      Pages: 524 - 530
      Abstract: Aswathy Sreedevi, Ambika Gopalakrishnan Unnikrishnan, Sundaram Ramaiyer Karimassery, Kuttikattu Soman Deepak
      Indian Journal of Endocrinology and Metabolism 2017 21(4):524-530
      Objective: This was an interventional study to understand the effect of two low-cost interventions; yoga and peer support on the quality of life (QOL) of women with type 2 diabetes. Methodology: An open label parallel three-armed randomized control trial was conducted among 124 recruited women with diabetes for 3 months. Block randomization with a block length of six was carried out. In the yoga arm, sessions by an instructor, consisting of a group of postures coordinated with breathing were conducted for an hour, 2 days a week. In the peer support arm, each peer mentor after training visited 13–14 women with diabetes every week followed by a phone call. The meeting was about applying disease management plans in daily life. At the beginning and end of the study, QOL was assessed by the translated, validated World Health Organization QOL-BREF in four domains physical, psychological, social, and environmental domains. Results: The majority (96%) of the study participants perceived the peer support and yoga intervention to be beneficial. Paired t-test revealed significant increases in the social and environmental domain in the peer group and in the environmental domain in the yoga group, though this disappeared in the between-group comparison perhaps due to poor glycemic control (hemoglobin A1c varied from 9.4 to 9.6) and the short duration of 3 months of the study. Conclusion: Peer support and yoga improved perceptions of QOL though its impact on scores was not significant due to a short period of study among women with poor glycemic control.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):524-530
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_28_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Effect of antithyroid therapies on bone and body composition: A
           prospective, randomized, clinical study comparing antithyroid drugs with
           radioiodine therapy

    • Authors: Shekhar Kansara, Narendra Kotwal, K. V. S. Hari Kumar, Yashpal Singh, Vimal Upreti, Amit Nachankar
      Pages: 531 - 534
      Abstract: Shekhar Kansara, Narendra Kotwal, K. V. S. Hari Kumar, Yashpal Singh, Vimal Upreti, Amit Nachankar
      Indian Journal of Endocrinology and Metabolism 2017 21(4):531-534
      Background: Thyrotoxicosis is associated with loss of body weight and bone mineral content (BMC). Antithyroid drugs (ATD) and radioiodine therapy (RIT) are the common options for the management of thyrotoxicosis. We evaluated the effect of ATD and RIT on BMC and body composition. Materials and Methods: In this prospective study, we randomized 60 patients of thyrotoxicosis (20–50 years, treatment naïve, males) to receive either ATD (Group 1) using carbimazole or RIT (Group 2). We excluded patients with significant ophthalmopathy and thyroid malignancy. The patients were followed serially for 1 year. Body composition was analyzed using the bioimpedance method and BMC by dual-energy X-ray absorptiometry technique. The data were analyzed using appropriate statistical measures. Results: The patients had a mean age of 33 ± 4.2 years and mean symptoms duration of 8.2 ± 2.7 months before the diagnosis. A total of 51 patients had Graves' disease, and the remaining 9 had toxic multinodular goiter. BMC at lumbar spine and femoral neck improved with both the therapies similarly at the end of 1 year. The body weight, protein, and fat content also increased after 1 year of observation similar between the two groups. None of the observed parameters showed a difference with regard to the mode of ATD. Conclusion: ATD and RIT have comparable effects on the bone and body composition in the management of thyrotoxicosis. Further long-term studies are needed to confirm the observed findings.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):531-534
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_103_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Osteoporosis in otherwise healthy patients with type 2 diabetes: A
           prospective gender based comparative study

    • Authors: Balram Sharma, Hema Singh, Praveen Chodhary, Sanjay Saran, Sandeep Kumar Mathur
      Pages: 535 - 539
      Abstract: Balram Sharma, Hema Singh, Praveen Chodhary, Sanjay Saran, Sandeep Kumar Mathur
      Indian Journal of Endocrinology and Metabolism 2017 21(4):535-539
      Background and Objective: Type 2 diabetes mellitus (T2DM) may affect bone loss differentially in adult males and postmenopausal females. We evaluated the prevalence of osteoporosis in otherwise healthy adults with T2DM. Materials and Methods: In a cross-sectional study, adults with T2DM, aged 50 years and above, were evaluated for bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) scan at spine and hip. T-score of ≤−2.5 was defined as osteoporosis and score −2.49 to −1.0 as osteopenia at either site. Correlation of low BMD with demographic, clinical, and laboratory parameters including serum Vitamin D and serum testosterone (in males) was evaluated. Results: In 200 patients, mean age was 64.5 ± 7.0 years and age differed significantly in males and females (P < 0.0001). Osteoporosis was present in 35.5% adults with T2DM. Significantly greater proportion of females had osteoporosis (49.5% vs. 22.3%, P< 0.0001). Frequency of osteoporosis at spine (33.5%) was higher than the same at hip (13.5%). Compared to males, significantly greater proportion of females had osteoporosis and osteopenia at both spine (P < 0.0001) and hip (P < 0.0001). Among all parameters assessed, a significant positive correlation of T-score at spine and hip was seen with body mass index in both males (r = 0.287, P = 0.003 at spine and r = 0.421, P< 0.0001 at hip) and females (r = 0.291, P = 0.004 at spine and r = 0.280, P = 0.010 at hip). There was no association of Vitamin D deficiency (45.5% patients) with either T-score and presence of osteoporosis either at spine (P = 0.388 and P = 0.177) or hip (P = 0.431 and P = 0.593). Conclusion: Prevalence of osteoporosis in otherwise healthy T2DM was 35.5% with greater prevalence in females than males. Body mass but not Vitamin D or testosterone has an important role in the determination of bone loss in T2DM.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):535-539
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_108_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • The serological and biochemical markers of adrenal cortex and endocrine
           pancreas dysfunction in patients with Hashimoto's thyroiditis: A
           hospital-based pilot study

    • Authors: Jaya Prakash Sahoo, Jayakumar Selviambigapathy, Sadishkumar Kamalanathan, VS Negi, MG Sridhar, Sitanshu Sekhar Kar, Muthupillai Vivekanandan
      Pages: 540 - 544
      Abstract: Jaya Prakash Sahoo, Jayakumar Selviambigapathy, Sadishkumar Kamalanathan, VS Negi, MG Sridhar, Sitanshu Sekhar Kar, Muthupillai Vivekanandan
      Indian Journal of Endocrinology and Metabolism 2017 21(4):540-544
      Background: The prevalence of both islet cell and adrenal autoimmunity among Asian Indian hypothyroidism patients with Hashimoto's thyroiditis (HT) is lacking in literature. Objectives: The objective of this study was to assess the proportion of Addison's disease (AD) and type 1 diabetes mellitus (T1DM) in patients with HT. Materials and Methods: The patients with hypothyroidism due to HT were included in this study over 2 years. Primary hypothyroidism was defined as high serum thyroid-stimulating hormone (>5.5 mIU/L) with or without low thyroxine level. HT was defined by the presence of high thyroid peroxidase antibody (Ab) titer (>35 IU/ml). Autoimmune markers of AD and T1DM, i.e., adrenal (21-hydroxylase) Ab, glutamic acid decarboxylase (GAD) Ab, and insulinoma-associated antigen-2 (IA-2) Ab were measured among them. In addition, 250 μg adrenocorticotropic hormone (ACTH) stimulation test was done in patients with adrenal Ab. Similarly, beta cell function was assessed in patients with GAD and/or IA-2 Ab. Results: Out of 150 patients screened, 136 patients were included in this study. Seven patients had adrenal Ab while 15 had IA-2 Ab. The GAD Ab was not present in any of the patients in the study. ACTH stimulation test was done in four of seven patients with adrenal Ab and beta cell function was assessed in 8 of 15 patients with islet cell Ab. All patients with adrenal Ab had normal adrenal function and 1 out of 15 with IA-2 Ab developed diabetes mellitus during follow-up. Conclusions: Either adrenal or islet cell Ab was found in 16% Asian Indian hypothyroidism patients with HT.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):540-544
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_72_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Menstrual cycle abnormalities in patients with prolactinoma and
           drug-induced hyperprolactinemia

    • Authors: Bindu Kulshreshtha, Isha Pahuja, Deepak Kothari, Indu Chawla, Neera Sharma, Shikha Gupta, Anuja Mittal
      Pages: 545 - 550
      Abstract: Bindu Kulshreshtha, Isha Pahuja, Deepak Kothari, Indu Chawla, Neera Sharma, Shikha Gupta, Anuja Mittal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):545-550
      Background and Objective: Hyperprolactinemia affects the reproductive endocrine axis; however, the degree of dysfunction may vary depending on etiology. The aim of the present study was to analyze menstrual cyclicity in patients with prolactinoma and drug-induced hyperprolactinemia (DIH). Methodology: Patients with prolactinoma and DIH were retrospectively analyzed for menstrual cyclicity at presentation and response to therapy. Results: Of 128 females with hyperprolactinemia, 58 had prolactinoma (41 microadenoma and 17 macroadenoma) and 39 had DIH. Patients with prolactinoma had higher prolactin levels and increased frequency of oligomenorrhea (77.5% vs. 46%) as compared to DIH. Patients with macroprolactinoma had more severe menstrual disturbances compared to microprolactinoma. A higher percentage of patients with microprolactinoma and DIH achieved regular menstrual cycles compared to macroprolactinoma postcabergoline treatment (85% and 90% vs. 65%). There was no correlation between time to regularization of menstrual cycles with age, menstrual cycle length, duration of menstrual irregularity, or initial prolactin level in patients with prolactinoma. Linear regression analysis showed a significant association between time to regularization of menstrual cycles with time to normalization of prolactin levels (P = 0.001). Conclusion: There is a prompt restoration of menstrual cycles in patients with microprolactinoma and DIH. Patients with macroprolactinoma have more severe menstrual disturbances and lesser frequency of cycle restoration postcabergoline treatment compared to microprolactinoma and DIH.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):545-550
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_515_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Increased levels of serum interleukin-17 in patients with
           Hashimoto&#39;s thyroiditis

    • Authors: Fatemeh Esfahanian, Roghayeh Ghelich, Hoda Rashidian, Zohreh Jadali
      Pages: 551 - 554
      Abstract: Fatemeh Esfahanian, Roghayeh Ghelich, Hoda Rashidian, Zohreh Jadali
      Indian Journal of Endocrinology and Metabolism 2017 21(4):551-554
      Background: CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17–producing T-helper cells in this common autoimmune thyroid disorder. Aim: The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT. Materials and Methods: Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay. Results: The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls. Conclusion: These results suggest that IL-17 could play some role in the pathogenesis of HT.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):551-554
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_412_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Effect of Vitamin D supplementation on vascular functions and oxidative
           stress in type 2 diabetic patients with Vitamin D deficiency

    • Authors: Nishanthi Anandabaskar, Sandhiya Selvarajan, Steven Aibor Dkhar, Sadish Kumar Kamalanathan, Kadhiravan Tamilarasu, Zachariah Bobby
      Pages: 555 - 563
      Abstract: Nishanthi Anandabaskar, Sandhiya Selvarajan, Steven Aibor Dkhar, Sadish Kumar Kamalanathan, Kadhiravan Tamilarasu, Zachariah Bobby
      Indian Journal of Endocrinology and Metabolism 2017 21(4):555-563
      Background: Vitamin D levels are reported to have an inverse liaison with the risk of cardiovascular diseases. Hence, we aimed to evaluate the effect of Vitamin D supplementation on changes in vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency. Subjects and Methods: One hundred and three patients with type 2 diabetes attending endocrinology outpatients department in a tertiary care hospital were screened for Vitamin D deficiency. Patients with serum 25-hydroxy Vitamin D levels <20 ng/ml were considered as deficient and were administered 60,000 IU of oral Vitamin D3 weekly for 8 weeks. In these patients, parameters of vascular functions (carotid-femoral pulse wave velocity, brachial-ankle pulse wave velocity, and arterial stiffness index) and oxidative stress (serum malondialdehyde levels and total antioxidant status) were measured at baseline and after 8 weeks of oral Vitamin D supplementation. Results: Among 103 patients with type 2 diabetes, 75 (72.82%) were found to have Vitamin D deficiency. Amidst these patients, carotid-femoral pulse wave velocity (991.6 ± 161.82 vs. 899.29 ± 151.86, P< 0.001), right brachial-ankle pulse wave velocity (1446.16 ± 204.33 vs. 1350.8 ± 178.39, P< 0.001), and left brachial-ankle pulse wave velocity (1493.81 ± 219.65 vs. 1367.61 ± 220.64, P< 0.001) showed a significant reduction following Vitamin D supplementation. Further, these patients were found to have significant fall in serum malondialdehyde levels with rise in total antioxidant status ensuing Vitamin D supplementation. Conclusion: The present study shows that oral Vitamin D supplementation of 60,000 IU/week for 8 weeks significantly improves vascular functions and reduces oxidative stress in type 2 diabetic patients with Vitamin D deficiency.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):555-563
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_140_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Occurrence and predictors of depression and poor quality of life among
           patients with Type-2 diabetes: A Northern India perspective

    • Authors: Prerna Bahety, Gunjan Agarwal, Deepak Khandelwal, Deep Dutta, Sanjay Kalra, Pankaj Taparia, Vikas Singhal
      Pages: 564 - 569
      Abstract: Prerna Bahety, Gunjan Agarwal, Deepak Khandelwal, Deep Dutta, Sanjay Kalra, Pankaj Taparia, Vikas Singhal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):564-569
      Background and Aims: Globally, depression has been linked to Type-2 diabetes mellitus (T2DM). However, similar data from India are scant. This study evaluated the occurrence and predictors of depression and health-related quality of life (QOL) in patients with T2DM as compared to healthy controls.Materials and Methods: One hundred adults with T2DM without prior diagnosis of depression and 100 matched controls were evaluated. Depression was assessed using Patient Health Questionnaire-9. World Health Organization QOL Brief (WHO-QOL-BREF) was used to assess QOL. Demography, anthropometry, biochemical parameters of diabetes control, and microvascular and macrovascular complications in patients were recorded. Results: Depression was significantly more common in T2DM (63%) as compared to controls (48%) (odds ratio [OR] - 1.84 [1.04, 3.24]; P = 0.03). In T2DM, depression was higher in patients with disease duration >5 years (OR = 2.66; P = 0.02), glycated hemoglobin >7% (OR = 3.45; P = 0.004), retinopathy (OR - 3.56; P = 0.03), and nephropathy (OR - 4.11; P = 0.07). Occurrence of depression was significantly higher among the patients with macrovascular complications, namely, coronary artery disease (17.4%; P = 0.000006), cerebrovascular disease (14.2%; P = 0.0006), and peripheral vascular disease (7.9%; P = 0.05). Insulin users had higher depression as compared to patients using only oral antihyperglycemic medications (P = 0.034). Patient with depression had significantly low QOL. The WHO-QOL for all the domains was significantly lower in T2DM with microvascular and macrovascular complications, as compared to those without. Conclusion: Indian T2DM had higher prevalence of depression and lower QOL as compared to controls, which was associated with poor glycemic control and higher end-organ damage. Public health measures are required to create more awareness for managing depression in diabetes.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):564-569
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_123_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • A study of the patients suffering from tuberculosis and
           tuberculosis-diabetes comorbidity in Revised National Tuberculosis Control
           Program Centers of Northern Madhya Pradesh, India

    • Authors: Anil Kumar Agarwal, Ginisha Gupta, Priyesh Marskole, Anju Agarwal
      Pages: 570 - 576
      Abstract: Anil Kumar Agarwal, Ginisha Gupta, Priyesh Marskole, Anju Agarwal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):570-576
      Background: Diabetes mellitus (DM) is recognized as an important risk factor to tuberculosis (TB). India has high TB burden, along with rising DM prevalence. Aim: This study was conducted to document the coexistence of DM and TB in persons with established TB under the Revised National Tuberculosis Control Program. Type of Study: This was a cross-sectional, descriptive observational study conducted at selected Directly Observed Therapy center in Gwalior North Central India. Materials and Methods: A total of 550 patients with confirmed diagnosis of TB and on treatment were recruited. The study participants were screened for DM and diagnoses were made on the basis of the World Health Organization criteria. Clinical parameters were compared between persons with DM and those without DM. Results: DM/TB co-morbidity was noted in 85 individuals and these made up 15.4% of the study population. The mean age was higher in DM patients with TB (43.4 ± 15.4 vs. 33.1 ± 16.2 years, P = 0.000); the mean duration of symptoms of TB with DM was more (124 ± 16.4 vs. 107.49 ± 10.3 days). Multinomial logistic regression analysis showed that increasing age, positive family history of diabetes, sedentary occupation, and presence of pulmonary TB were significantly associated with diabetes among TB patients. Conclusions: Diabetes is an important co-morbid feature to be sought in patients with TB. This study re-echo the need to raise awareness on screening for DM in persons with TB.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):570-576
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_89_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Prevalence of thyroid peroxidase antibody and pregnancy outcome in
           euthyroid autoimmune positive pregnant women from a tertiary care center
           in Haryana

    • Authors: Rajesh Rajput, Tekchand Yadav, Shashi Seth, Smiti Nanda
      Pages: 577 - 580
      Abstract: Rajesh Rajput, Tekchand Yadav, Shashi Seth, Smiti Nanda
      Indian Journal of Endocrinology and Metabolism 2017 21(4):577-580
      Objective: To study the prevalence of thyroid peroxidase autoantibody in euthyroid pregnant women and to evaluate the association between thyroid peroxidase autoantibody and pregnancy outcomes. Materials and Methods: One thousand thirty consecutive pregnant women attending the antenatal clinic over a period of 1 year and were carrying a healthy singleton uncomplicated intrauterine pregnancy and consuming iodized salt were recruited for the study. Outcomes of the pregnancy was compared between TPO antibody positive euthyroid women (group 1) and TPO antibody negative euthyroid women (group 2). Results: Out of 1030 women, 164 (18.9%) were detected TPO antibody positive with euthyroid status. The mean FT4 and TSH level were significantly different in those who were TPO Ab positive as compared TPO Ab negative euthyroid pregnant women. No correlation was observed between the maternal age, gestational age and gravidity with anti TPO antibody levels. Eighteen (12%) women in Group 1and 5 (3.3%) women in Group 2 had miscarriages and the difference was found to be statistically significant (P value of 0.004). Twenty-one (14%) women in Group 1 and 5 (3.3%) women in Group 2 had preterm deliveries, which was also found to be statistically significantly (p value of 0.001). Other pregnancy related complications like Intrauterine death, IUGR, preeclampsia and PIH though are present in comparatively higher number in TPO Ab positive euthyroid pregnant women as compared to TPO Ab negative euthyroid pregnant women but this difference was not found to be statistically significant. Conclusions: To conclude with the present study shows that a good number of pregnant women with euthyroid status have TPO Ab positivity and this is associated with some adverse pregnancy outcomes like miscarriage and preterm birth of the baby.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):577-580
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_397_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Randomized placebo control study of metformin in psoriasis patients with
           metabolic syndrome (systemic treatment cohort)

    • Authors: Surjit Singh, Anil Bhansali
      Pages: 581 - 587
      Abstract: Surjit Singh, Anil Bhansali
      Indian Journal of Endocrinology and Metabolism 2017 21(4):581-587
      Background: Psoriasis has been found to be associated with obesity, metabolic syndrome (MS), diabetes, and cardiovascular risk factors. Metformin treatment showed improvement in cardiovascular risk factors and hyperinsulinemia. Objective: To evaluate the efficacy and safety of metformin in psoriasis patients with MS. Materials and Methods: This was a single-center, parallel-group, randomized, open-label study with blinded end point assessment of metformin (1000 mg once daily for 12 weeks; n = 20) and placebo (n = 18) in psoriasis patients with MS. Total sample size was 38 participants. Results: Statistically significant improvement was observed in mean percentage change in erythema, scaling, and induration (ESI) (P = 0.048) in metformin as compared to placebo while mean percentage change in psoriasis area and severity index (PASI) and physician global assessment (PGA) scores was not significant (PASI - P = 0.215, PGA - P = 0.070). There was a statistically significant difference in percentage of parameters of MS improved following 12 weeks of treatment in metformin (19%) as compared to placebo (8.9%) group (P = 0.046). Statistically significant difference in percentage of patients achieving 75% reduction in ESI scores (P = 0.024). Significant improvement was observed in mean weight, body mass index (BMI), total cholesterol, and low-density lipoprotein (LDL) cholesterol in metformin group as compared to placebo. Improvement in BMI, fasting plasma glucose, serum triglycerides, high-density lipoprotein, LDL, systolic blood pressure, diastolic blood pressure, and total cholesterol was statistically significant in metformin group over the period of 12 weeks. There was no significant difference in adverse events in two groups except weight gain. Conclusion: Metformin has shown improvement in psoriasis and parameters of MS, hence can be used for the benefit of psoriasis patients having MS. Large, controlled studies are needed to confirm.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):581-587
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_46_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Gestational weight gain and pregnancy outcomes in relation to body mass
           index in Asian Indian women

    • Authors: Balaji Bhavadharini, Ranjit Mohan Anjana, Mohan Deepa, Gopal Jayashree, Subramanyam Nrutya, Mahadevan Shobana, Belma Malanda, Arivudainambi Kayal, Anne Belton, Kurian Joseph, Kurian Rekha, Ram Uma, Viswanathan Mohan
      Pages: 588 - 593
      Abstract: Balaji Bhavadharini, Ranjit Mohan Anjana, Mohan Deepa, Gopal Jayashree, Subramanyam Nrutya, Mahadevan Shobana, Belma Malanda, Arivudainambi Kayal, Anne Belton, Kurian Joseph, Kurian Rekha, Ram Uma, Viswanathan Mohan
      Indian Journal of Endocrinology and Metabolism 2017 21(4):588-593
      Aim: The aim of the study was to compare the weight gain during pregnancy (using Institute of Medicine guidelines) among Asian Indians across different body mass index (BMI) categories (using World Health Organization Asia Pacific BMI cut points) and to compare the pregnancy outcomes in each of the different BMI categories. Methodology: Retrospective records of 2728 pregnant women attending antenatal clinics and private maternity centers in Chennai, South India, from January 2011 to January 2014 were studied. Pregnancy outcomes were analyzed in relation to BMI and weight gain across different BMI categories. Results: Overweight and obese women who gained more weight during pregnancy were at high risk of delivering macrosomic infants (overweight - odds ratio [OR]: 2.3, 95% confidence interval [CI]: 1.1–5.2, P = 0.02 and obese - OR: 1.6, 95% CI: 1.1–2.4, P = 0.01). In addition, obese women who gained more weight were also at high risk of preterm labor (OR: 2.1, 95% CI: 1.1–3.8; P = 0.01), cesarean section (OR: 1.9, 95% CI: 1.4–2.5; P< 0.001), and preeclampsia (OR: 2.8, 95% CI: 1.1–7.2, P = 0.03). Normal weight and overweight women who gained less weight had a protective effect from cesarean section and macrosomia. Conclusions: Overweight/obese women who gained more weight than recommended are at a high risk of developing adverse pregnancy outcomes. Normal and overweight women who gained weight less than recommended have low risk for cesarean section and macrosomia. However, they have a higher (statistically insignificant) risk for low birth weight and preterm birth. This highlights the need for gaining adequate weight during pregnancy.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):588-593
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_557_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Indirect calorimetry: From bench to bedside

    • Authors: Riddhi Das Gupta, Roshna Ramachandran, Padmanaban Venkatesan, Shajith Anoop, Mini Joseph, Nihal Thomas
      Pages: 594 - 599
      Abstract: Riddhi Das Gupta, Roshna Ramachandran, Padmanaban Venkatesan, Shajith Anoop, Mini Joseph, Nihal Thomas
      Indian Journal of Endocrinology and Metabolism 2017 21(4):594-599
      Accurate determination of energy expenditure (EE) is vitally important yet often neglected in clinical practice. Indirect calorimetry (IC) provides one of the most sensitive, accurate, and noninvasive measurements of EE in an individual. Over the last couple of decades, this technique has been applied to clinical circumstances such as acute illness and parenteral nutrition. Beyond assessing the nutritional needs, it has also shed light on various aspects of nutrient assimilation, thermogenesis, the energetics of physical exercise, and the pathogenesis of obesity and diabetes. However, because of little or no experience with IC provided during medical education, the benefits of IC are poorly appreciated. Newer technology, cost-effectiveness, and a better understanding of how to interpret measurements should lead to more frequent use of IC. This review focuses on the physicochemical background of IC, the various indications for use, techniques and instruments, potential pitfalls in measurement, and the recent advances in technology that has adapted the technique to long-term studies in humans.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):594-599
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_484_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Forum for injection technique and therapy expert recommendations, India:
           The Indian recommendations for best practice in insulin injection
           technique, 2017

    • Authors: Nikhil Tandon, Sanjay Kalra, Yatan Pal Singh Balhara, Manash P Baruah, Manoj Chadha, Hemraj B Chandalia, KM Prasanna Kumar, SV Madhu, Ambrish Mithal, Rakesh Sahay, Rishi Shukla, Annamalai Sundaram, Ambika G Unnikrishnan, Banshi Saboo, Vandita Gupta, Subhankar Chowdhury, Jothydev Kesavadev, Subhash K Wangnoo
      Pages: 600 - 617
      Abstract: Nikhil Tandon, Sanjay Kalra, Yatan Pal Singh Balhara, Manash P Baruah, Manoj Chadha, Hemraj B Chandalia, KM Prasanna Kumar, SV Madhu, Ambrish Mithal, Rakesh Sahay, Rishi Shukla, Annamalai Sundaram, Ambika G Unnikrishnan, Banshi Saboo, Vandita Gupta, Subhankar Chowdhury, Jothydev Kesavadev, Subhash K Wangnoo
      Indian Journal of Endocrinology and Metabolism 2017 21(4):600-617
      Health-care professionals in India frequently manage injection or infusion therapies in persons with diabetes (PWD). Patients taking insulin should know the importance of proper needle size, correct injection process, complication avoidance, and all other aspects of injection technique from the first visit onward. To assist health-care practitioners in their clinical practice, Forum for Injection Technique and Therapy Expert Recommendations, India, has updated the practical advice and made it more comprehensive evidence-based best practice information. Adherence to these updated recommendations, learning, and translating them into clinical practice should lead to effective therapies, improved outcomes, and lower costs for PWD.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):600-617
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_97_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Dose modification of antidiabetic agents in patients with type 2 diabetes
           mellitus and heart failure

    • Authors: DC Sharma, Arthur Asirvatham, Parminder Singh
      Pages: 618 - 629
      Abstract: DC Sharma, Arthur Asirvatham, Parminder Singh
      Indian Journal of Endocrinology and Metabolism 2017 21(4):618-629
      Heart failure is the most common comorbidity of diabetes. The incidence of heart failure in patients with diabetes is about 9%–22%, which is four times higher Than that in patients without diabetes. Heart failure and diabetes are collectively associated with increased morbidity and mortality compared to either condition alone. Several epidemiological studies have demonstrated an increased risk of heart failure in patients with diabetes; moreover, poor glycemic control accounts for the increased risk of heart failure. At present, several oral (metformin, sulfonylureas, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, etc.) as well as injectable (insulins, glucagon-like peptide 1 receptor agonists) antidiabetic agents are available. However, optimal treatment strategy to achieve adequate glycemic control in patients with type 2 diabetes mellitus (T2DM) and heart failure has not been well studied. In the view of rising prevalence of heart failure in patients with diabetes mellitus, clinicians need to understand the potential implications of antidiabetic agents in patients with heart failure. A group of experts from across India were involved in a consensus meeting in Pondicherry during the National Insulin Summit in November 2015. They evaluated agents currently available for the treatment of diabetes looking at existing scientific evidence relevant to each class of therapy. In addition, the existing guidelines and prescribing literature available with all these agents were also reviewed. Findings from the expert evaluations were then factored into the national context incorporating personal experience and common clinical practices in India. The purpose of this consensus document is to assist the clinicians while treating patients with T2DM and heart failure.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):618-629
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_442_16
      Issue No: Vol. 21, No. 4 (2017)
       
  • Medication counseling for thyroxine

    • Authors: Sanjay Kalra, AG Unnikrishnan, Mangesh Tiwaskar, Rakesh Sahay, Banshi Saboo, Vijay Negalur, Deepak Khandelwal, Pritam Gupta, Sujoy Ghosh, AK Das, Ganapathi Bantwal, Sarita Bajaj, Sameer Agarwal, Rashmi Aggarwal, Navneet Agarwal
      Pages: 630 - 631
      Abstract: Sanjay Kalra, AG Unnikrishnan, Mangesh Tiwaskar, Rakesh Sahay, Banshi Saboo, Vijay Negalur, Deepak Khandelwal, Pritam Gupta, Sujoy Ghosh, AK Das, Ganapathi Bantwal, Sarita Bajaj, Sameer Agarwal, Rashmi Aggarwal, Navneet Agarwal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):630-631
      This communication from the National Indian Patient-centered Thyroid Management group provides a useful tool to help in medication counseling during hypothyroidism management. The authors classify and list aspects of thyroxine use which must be discussed with patients on thyroxine supplementation or replacement. Issues related to concomitant food and medications intake, preconception and pregnancy management, as well as sick day care, are also discussed.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):630-631
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_91_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Thyro-stress

    • Authors: Sanjay Kalra, Komal Verma, Yatan Pal Singh Balhara
      Pages: 632 - 633
      Abstract: Sanjay Kalra, Komal Verma, Yatan Pal Singh Balhara
      Indian Journal of Endocrinology and Metabolism 2017 21(4):632-633
      Our understanding of the biopsychosocial model of health, and its influence on chronic endocrine conditions, has improved over the past few decades. We can distinguish, for example, between diabetes distress and major depressive disorders in diabetes. Similar to diabetes distress, we suggest the existence of “thyrostress” in chronic thyroid disorders. Thyro-stress is defined as an emotional state, characterized by extreme apprehension, discomfort or dejection, caused by the challenges and demand of living with thyroid disorders such as hypothyroidism. This communication describes the etiology, clinical features, differential diagnosis, and management of thyro-stress.
      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):632-633
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_136_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Cardiovascular safety of oral antidiabetic medications: Need of the hour

    • Authors: Prashant Ulhas Kaduskar
      Pages: 634 - 635
      Abstract: Prashant Ulhas Kaduskar
      Indian Journal of Endocrinology and Metabolism 2017 21(4):634-635

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):634-635
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_47_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Vitamin D deficiency among healthy children: An undisputed and booming
           problem

    • Authors: Suresh Kumar Angurana, Vikas Mahajan
      Pages: 635 - 636
      Abstract: Suresh Kumar Angurana, Vikas Mahajan
      Indian Journal of Endocrinology and Metabolism 2017 21(4):635-636

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):635-636
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_76_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Does testosterone replacement therapy promote an augmented risk of
           thrombotic events in thalassemia major male patients with hypogonadism?

    • Authors: Vincenzo De Sanctis, Shahina Daar, Ashraf T Soliman, Heba Elsedfy, Doaa Khater, Salvatore Di Maio
      Pages: 636 - 637
      Abstract: Vincenzo De Sanctis, Shahina Daar, Ashraf T Soliman, Heba Elsedfy, Doaa Khater, Salvatore Di Maio
      Indian Journal of Endocrinology and Metabolism 2017 21(4):636-637

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):636-637
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_73_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Pandora&#39;s box: Neurological manifestations of
           hypoparathyroidism

    • Authors: Ambarish Bhattacharya, Kaushik Ghosh, Nilanjan Sengupta
      Pages: 638 - 639
      Abstract: Ambarish Bhattacharya, Kaushik Ghosh, Nilanjan Sengupta
      Indian Journal of Endocrinology and Metabolism 2017 21(4):638-639

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):638-639
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_44_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • On the therapy for polycystic ovary syndrome

    • Authors: Vittorio Unfer, Giovanni Monastra
      Pages: 639 - 640
      Abstract: Vittorio Unfer, Giovanni Monastra
      Indian Journal of Endocrinology and Metabolism 2017 21(4):639-640

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):639-640
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_409_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Iodine deficiency: An under recognized problem

    • Authors: Sudha Rathna Prabhu, Subramanian Kannan, Shriraam Mahadevan
      Pages: 640 - 641
      Abstract: Sudha Rathna Prabhu, Subramanian Kannan, Shriraam Mahadevan
      Indian Journal of Endocrinology and Metabolism 2017 21(4):640-641

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):640-641
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_39_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Parathyromatosis following endoscopic parathyroid surgery: A rare
           occurrence

    • Authors: Ajay Aggarwal, Roopak Wadhwa, Vivek Aggarwal
      Pages: 641 - 642
      Abstract: Ajay Aggarwal, Roopak Wadhwa, Vivek Aggarwal
      Indian Journal of Endocrinology and Metabolism 2017 21(4):641-642

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):641-642
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_61_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Challenges facing optimum care of diabetic children in Iraq

    • Authors: Mahmood Dhahir Al-Mendalawi
      Pages: 642 - 643
      Abstract: Mahmood Dhahir Al-Mendalawi
      Indian Journal of Endocrinology and Metabolism 2017 21(4):642-643

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):642-643
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_122_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • Metabolic karma in diabetes care: Medico-philosophical reflections

    • Authors: Sanjay Kalra, Pallavi Kawatra
      Pages: 643 - 644
      Abstract: Sanjay Kalra, Pallavi Kawatra
      Indian Journal of Endocrinology and Metabolism 2017 21(4):643-644

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):643-644
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_120_17
      Issue No: Vol. 21, No. 4 (2017)
       
  • “Syndrome of inappropriate antidiuretic hormone secretion” as
           a diagnostic and a prognostic indicator in olfactory neuroblastoma

    • Authors: K Devaraja, Kapil Sikka, Rajeev Kumar, Prem Sagar
      Pages: 644 - 645
      Abstract: K Devaraja, Kapil Sikka, Rajeev Kumar, Prem Sagar
      Indian Journal of Endocrinology and Metabolism 2017 21(4):644-645

      Citation: Indian Journal of Endocrinology and Metabolism 2017 21(4):644-645
      PubDate: Fri,9 Jun 2017
      DOI: 10.4103/ijem.IJEM_94_17
      Issue No: Vol. 21, No. 4 (2017)
       
 
 
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