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Publisher: Medknow Publishers   (Total: 355 journals)

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Showing 1 - 200 of 355 Journals sorted alphabetically
Advanced Arab Academy of Audio-Vestibulogy J.     Open Access  
Advances in Human Biology     Open Access   (Followers: 1)
African J. for Infertility and Assisted Conception     Open Access  
African J. of Business Ethics     Open Access   (Followers: 6)
African J. of Medical and Health Sciences     Open Access   (Followers: 1)
African J. of Paediatric Surgery     Open Access   (Followers: 7, SJR: 0.269, h-index: 10)
African J. of Trauma     Open Access  
Ain-Shams J. of Anaesthesiology     Open Access   (Followers: 3)
Al-Azhar Assiut Medical J.     Open Access  
Al-Basar Intl. J. of Ophthalmology     Open Access   (Followers: 1)
Ancient Science of Life     Open Access   (Followers: 6)
Anesthesia : Essays and Researches     Open Access   (Followers: 7)
Annals of African Medicine     Open Access   (Followers: 1, SJR: 0.331, h-index: 15)
Annals of Bioanthropology     Open Access   (Followers: 3)
Annals of Cardiac Anaesthesia     Open Access   (Followers: 13, SJR: 0.408, h-index: 15)
Annals of Indian Academy of Neurology     Open Access   (Followers: 3, SJR: 0.308, h-index: 14)
Annals of Maxillofacial Surgery     Open Access   (Followers: 6)
Annals of Medical and Health Sciences Research     Open Access   (Followers: 7)
Annals of Nigerian Medicine     Open Access   (Followers: 1)
Annals of Pediatric Cardiology     Open Access   (Followers: 7, SJR: 0.441, h-index: 10)
Annals of Saudi Medicine     Open Access   (SJR: 0.24, h-index: 29)
Annals of Thoracic Medicine     Open Access   (Followers: 4, SJR: 0.388, h-index: 19)
Annals of Tropical Medicine and Public Health     Open Access   (Followers: 15, SJR: 0.148, h-index: 5)
APOS Trends in Orthodontics     Open Access   (Followers: 1)
Arab J. of Interventional Radiology     Open Access  
Archives of Intl. Surgery     Open Access   (Followers: 9)
Archives of Medicine and Health Sciences     Open Access   (Followers: 3)
Archives of Pharmacy Practice     Open Access   (Followers: 5)
Asia Pacific J. of Clinical Trials : Nervous System Diseases     Open Access  
Asia-Pacific J. of Oncology Nursing     Open Access   (Followers: 3)
Asian J. of Andrology     Open Access   (Followers: 1, SJR: 0.879, h-index: 49)
Asian J. of Neurosurgery     Open Access   (Followers: 2)
Asian J. of Oncology     Open Access   (Followers: 1)
Asian J. of Transfusion Science     Open Access   (Followers: 2, SJR: 0.362, h-index: 10)
Astrocyte     Open Access  
Avicenna J. of Medicine     Open Access   (Followers: 1)
AYU : An international quarterly journal of research in Ayurveda     Open Access   (Followers: 6)
Benha Medical J.     Open Access  
BLDE University J. of Health Sciences     Open Access  
Brain Circulation     Open Access  
Bulletin of Faculty of Physical Therapy     Open Access   (Followers: 1)
Cancer Translational Medicine     Open Access   (Followers: 1)
CHRISMED J. of Health and Research     Open Access  
Clinical Dermatology Review     Open Access   (Followers: 1)
Clinical Trials in Degenerative Diseases     Open Access  
Clinical Trials in Orthopedic Disorders     Open Access   (Followers: 1)
Community Acquired Infection     Open Access  
Conservation and Society     Open Access   (Followers: 12, SJR: 0.82, h-index: 12)
Contemporary Clinical Dentistry     Open Access   (Followers: 4)
Current Medical Issues     Open Access   (Followers: 1)
CytoJ.     Open Access   (Followers: 2, SJR: 0.339, h-index: 19)
Delta J. of Ophthalmology     Open Access  
Dental Hypotheses     Open Access   (Followers: 3, SJR: 0.131, h-index: 4)
Dental Research J.     Open Access   (Followers: 9)
Dentistry and Medical Research     Open Access  
Digital Medicine     Open Access  
Drug Development and Therapeutics     Open Access  
Education for Health     Open Access   (Followers: 5, SJR: 0.205, h-index: 22)
Egyptian J. of Bronchology     Open Access  
Egyptian J. of Cardiothoracic Anesthesia     Open Access  
Egyptian J. of Cataract and Refractive Surgery     Open Access   (Followers: 1)
Egyptian J. of Dermatology and Venerology     Open Access   (Followers: 1)
Egyptian J. of Haematology     Open Access  
Egyptian J. of Internal Medicine     Open Access   (Followers: 1)
Egyptian J. of Neurology, Psychiatry and Neurosurgery     Open Access   (Followers: 1, SJR: 0.121, h-index: 3)
Egyptian J. of Obesity, Diabetes and Endocrinology     Open Access  
Egyptian J. of Otolaryngology     Open Access   (Followers: 1)
Egyptian J. of Psychiatry     Open Access   (Followers: 2)
Egyptian J. of Surgery     Open Access   (Followers: 1)
Egyptian Orthopaedic J.     Open Access  
Egyptian Pharmaceutical J.     Open Access  
Egyptian Retina J.     Open Access  
Egyptian Rheumatology and Rehabilitation     Open Access  
Endodontology     Open Access  
Endoscopic Ultrasound     Open Access   (SJR: 0.473, h-index: 8)
Environmental Disease     Open Access  
European J. of Dentistry     Open Access   (Followers: 2, SJR: 0.496, h-index: 11)
European J. of General Dentistry     Open Access   (Followers: 1)
European J. of Prosthodontics     Open Access   (Followers: 2)
European J. of Psychology and Educational Studies     Open Access   (Followers: 7)
Fertility Science and Research     Open Access  
Formosan J. of Surgery     Open Access   (SJR: 0.107, h-index: 5)
Genome Integrity     Open Access   (Followers: 4, SJR: 1.227, h-index: 12)
Global J. of Transfusion Medicine     Open Access   (Followers: 1)
Heart India     Open Access   (Followers: 1)
Heart Views     Open Access   (Followers: 2)
Hepatitis B Annual     Open Access   (Followers: 3)
IJS Short Reports     Open Access  
Indian Anaesthetists Forum     Open Access  
Indian Dermatology Online J.     Open Access   (Followers: 3)
Indian J. of Allergy, Asthma and Immunology     Open Access   (Followers: 1)
Indian J. of Anaesthesia     Open Access   (Followers: 8, SJR: 0.302, h-index: 13)
Indian J. of Burns     Open Access   (Followers: 1)
Indian J. of Cancer     Open Access   (SJR: 0.318, h-index: 26)
Indian J. of Cerebral Palsy     Open Access   (Followers: 1)
Indian J. of Community Medicine     Open Access   (Followers: 2, SJR: 0.618, h-index: 16)
Indian J. of Critical Care Medicine     Open Access   (Followers: 2, SJR: 0.307, h-index: 16)
Indian J. of Dental Research     Open Access   (Followers: 4, SJR: 0.243, h-index: 24)
Indian J. of Dental Sciences     Open Access  
Indian J. of Dentistry     Open Access   (Followers: 1)
Indian J. of Dermatology     Open Access   (Followers: 2, SJR: 0.448, h-index: 16)
Indian J. of Dermatology, Venereology and Leprology     Open Access   (Followers: 3, SJR: 0.563, h-index: 29)
Indian J. of Dermatopathology and Diagnostic Dermatology     Open Access  
Indian J. of Drugs in Dermatology     Open Access   (Followers: 1)
Indian J. of Endocrinology and Metabolism     Open Access   (Followers: 4)
Indian J. of Health Sciences     Open Access   (Followers: 2)
Indian J. of Medical and Paediatric Oncology     Open Access   (SJR: 0.292, h-index: 9)
Indian J. of Medical Microbiology     Open Access   (Followers: 1, SJR: 0.53, h-index: 34)
Indian J. of Medical Research     Open Access   (Followers: 4, SJR: 0.716, h-index: 60)
Indian J. of Medical Sciences     Open Access   (Followers: 2, SJR: 0.207, h-index: 31)
Indian J. of Multidisciplinary Dentistry     Open Access   (Followers: 1)
Indian J. of Nephrology     Open Access   (Followers: 1, SJR: 0.233, h-index: 12)
Indian J. of Nuclear Medicine     Open Access   (Followers: 2, SJR: 0.213, h-index: 5)
Indian J. of Occupational and Environmental Medicine     Open Access   (Followers: 4, SJR: 0.203, h-index: 13)
Indian J. of Ophthalmology     Open Access   (Followers: 5, SJR: 0.536, h-index: 34)
Indian J. of Oral Health and Research     Open Access  
Indian J. of Oral Sciences     Open Access   (Followers: 1)
Indian J. of Orthopaedics     Open Access   (Followers: 9, SJR: 0.393, h-index: 15)
Indian J. of Otology     Open Access   (Followers: 1, SJR: 0.218, h-index: 5)
Indian J. of Paediatric Dermatology     Open Access   (Followers: 2)
Indian J. of Pain     Open Access   (Followers: 1)
Indian J. of Palliative Care     Open Access   (Followers: 5, SJR: 0.35, h-index: 12)
Indian J. of Pathology and Microbiology     Open Access   (Followers: 1, SJR: 0.285, h-index: 22)
Indian J. of Pharmacology     Open Access   (SJR: 0.347, h-index: 44)
Indian J. of Plastic Surgery     Open Access   (Followers: 12, SJR: 0.303, h-index: 13)
Indian J. of Psychiatry     Open Access   (Followers: 3, SJR: 0.496, h-index: 15)
Indian J. of Psychological Medicine     Open Access   (Followers: 1, SJR: 0.344, h-index: 9)
Indian J. of Public Health     Open Access   (Followers: 1, SJR: 0.444, h-index: 17)
Indian J. of Radiology and Imaging     Open Access   (Followers: 4, SJR: 0.253, h-index: 14)
Indian J. of Research in Homoeopathy     Open Access  
Indian J. of Rheumatology     Open Access   (SJR: 0.169, h-index: 7)
Indian J. of Sexually Transmitted Diseases and AIDS     Open Access   (Followers: 2, SJR: 0.313, h-index: 9)
Indian J. of Social Psychiatry     Open Access   (Followers: 2)
Indian J. of Urology     Open Access   (Followers: 3, SJR: 0.366, h-index: 16)
Indian J. of Vascular and Endovascular Surgery     Open Access   (Followers: 2)
Industrial Psychiatry J.     Open Access   (Followers: 2)
Intl. J. of Academic Medicine     Open Access  
Intl. J. of Advanced Medical and Health Research     Open Access  
Intl. J. of Applied and Basic Medical Research     Open Access  
Intl. J. of Clinical and Experimental Physiology     Open Access   (Followers: 1)
Intl. J. of Critical Illness and Injury Science     Open Access   (Followers: 1)
Intl. J. of Educational and Psychological Researches     Open Access   (Followers: 3)
Intl. J. of Environmental Health Engineering     Open Access   (Followers: 1)
Intl. J. of Forensic Odontology     Open Access   (Followers: 1)
Intl. J. of Green Pharmacy     Open Access   (Followers: 4, SJR: 0.229, h-index: 13)
Intl. J. of Health & Allied Sciences     Open Access   (Followers: 3)
Intl. J. of Health System and Disaster Management     Open Access   (Followers: 3)
Intl. J. of Heart Rhythm     Open Access  
Intl. J. of Medicine and Public Health     Open Access   (Followers: 7)
Intl. J. of Mycobacteriology     Open Access   (SJR: 0.239, h-index: 4)
Intl. J. of Noncommunicable Diseases     Open Access  
Intl. J. of Nutrition, Pharmacology, Neurological Diseases     Open Access   (Followers: 4)
Intl. J. of Oral Health Sciences     Open Access   (Followers: 1)
Intl. J. of Orthodontic Rehabilitation     Open Access  
Intl. J. of Pedodontic Rehabilitation     Open Access  
Intl. J. of Pharmaceutical Investigation     Open Access   (Followers: 1)
Intl. J. of Preventive Medicine     Open Access   (Followers: 1, SJR: 0.523, h-index: 15)
Intl. J. of Shoulder Surgery     Open Access   (Followers: 7, SJR: 0.611, h-index: 9)
Intl. J. of Trichology     Open Access   (SJR: 0.37, h-index: 10)
Intl. J. of Yoga     Open Access   (Followers: 15)
Intl. J. of Yoga : Philosophy, Psychology and Parapsychology     Open Access   (Followers: 6)
Iranian J. of Nursing and Midwifery Research     Open Access   (Followers: 2)
Iraqi J. of Hematology     Open Access  
J. of Academy of Medical Sciences     Open Access  
J. of Advanced Pharmaceutical Technology & Research     Open Access   (Followers: 4, SJR: 0.427, h-index: 15)
J. of Anaesthesiology Clinical Pharmacology     Open Access   (Followers: 8, SJR: 0.416, h-index: 14)
J. of Applied Hematology     Open Access  
J. of Association of Chest Physicians     Open Access   (Followers: 2)
J. of Basic and Clinical Reproductive Sciences     Open Access   (Followers: 1)
J. of Cancer Research and Therapeutics     Open Access   (Followers: 4, SJR: 0.359, h-index: 21)
J. of Carcinogenesis     Open Access   (Followers: 1, SJR: 1.152, h-index: 26)
J. of Cardiothoracic Trauma     Open Access  
J. of Cardiovascular Disease Research     Open Access   (Followers: 3, SJR: 0.351, h-index: 13)
J. of Cardiovascular Echography     Open Access   (SJR: 0.134, h-index: 2)
J. of Cleft Lip Palate and Craniofacial Anomalies     Open Access   (Followers: 2)
J. of Clinical and Preventive Cardiology     Open Access   (Followers: 1)
J. of Clinical Imaging Science     Open Access   (Followers: 1, SJR: 0.277, h-index: 8)
J. of Clinical Neonatology     Open Access   (Followers: 1)
J. of Clinical Ophthalmology and Research     Open Access   (Followers: 2)
J. of Clinical Sciences     Open Access  
J. of Conservative Dentistry     Open Access   (Followers: 4, SJR: 0.532, h-index: 10)
J. of Craniovertebral Junction and Spine     Open Access   (Followers: 4, SJR: 0.199, h-index: 9)
J. of Current Medical Research and Practice     Open Access  
J. of Current Research in Scientific Medicine     Open Access  
J. of Cutaneous and Aesthetic Surgery     Open Access   (Followers: 1)
J. of Cytology     Open Access   (Followers: 1, SJR: 0.274, h-index: 9)
J. of Dental and Allied Sciences     Open Access   (Followers: 1)
J. of Dental Implants     Open Access   (Followers: 7)
J. of Dental Lasers     Open Access   (Followers: 2)
J. of Dental Research and Review     Open Access   (Followers: 1)
J. of Digestive Endoscopy     Open Access   (Followers: 3)
J. of Dr. NTR University of Health Sciences     Open Access  
J. of Earth, Environment and Health Sciences     Open Access   (Followers: 1)
J. of Education and Ethics in Dentistry     Open Access   (Followers: 5)
J. of Education and Health Promotion     Open Access   (Followers: 5)
J. of Emergencies, Trauma and Shock     Open Access   (Followers: 9, SJR: 0.353, h-index: 14)
J. of Engineering and Technology     Open Access   (Followers: 6)
J. of Experimental and Clinical Anatomy     Open Access   (Followers: 2)
J. of Family and Community Medicine     Open Access   (Followers: 2)
J. of Family Medicine and Primary Care     Open Access   (Followers: 10)

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Journal Cover Indian Journal of Pathology and Microbiology
  [SJR: 0.285]   [H-I: 22]   [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0377-4929 - ISSN (Online) 0974-5130
   Published by Medknow Publishers Homepage  [355 journals]
  • From Editor's desk

    • Authors: Vatsala Misra
      Pages: 311 - 311
      Abstract: Vatsala Misra
      Indian Journal of Pathology and Microbiology 2017 60(3):311-311

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):311-311
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_584_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Cardiac myxomas with glandular elements

    • Authors: Pradeep Vaideeswar
      Pages: 312 - 312
      Abstract: Pradeep Vaideeswar
      Indian Journal of Pathology and Microbiology 2017 60(3):312-312

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):312-312
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_448_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Nucleic acid amplification testing in Indian blood banks: A review with
           perspectives

    • Authors: Kanjaksha Ghosh, Kanchan Mishra
      Pages: 313 - 318
      Abstract: Kanjaksha Ghosh, Kanchan Mishra
      Indian Journal of Pathology and Microbiology 2017 60(3):313-318
      Background: Nucleic acid amplification testing (NAT) is restricted to a few blood banks in India since 2008. This review was directed toward understanding NAT yield in different parts of the country and prevalence in the NAT of different types of virus. Materials and Methods: English literature was searched from 1990 to 2016 in PubMed, Scopus, Ind med, and Google database using properly constructed key words. Literature was collected and finally the data were synthesized. Results: NAT results from 11 publications and one personal communication showed that till date 389387 blood units have been NAT tested from various parts of the country. NAT yield varied from 1:476 to 1:4403 in various studies. Till date, 58/2550 (2%) blood banks of India are doing NAT testing but all of them have not published their results. Majority of the centers have used ID-NAT (Individual NAT) protocol and 21 blood banks are using minipool format of the test. One center has used in-house NAT testing system. In >70% of the time, the NAT positivity with due to hepatitis B (Hep B). For individual infection, NAT yield from the pooled data showed HIV in 1:66,000, Hep C virus 1:5484 and Hep B in 1:1761 seronegative donors. Discussion and Conclusion: In view of the very high NAT yield (1:1361), NAT in some from needs to be universally applied in Indian blood banks. However, the high Hep B occult infection suggests stricter donor selection and immunization of adults for Hep B may be way forward toward ensuring the viral safety of blood components in India.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):313-318
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_361_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Immunohistochemical characterization of glandular elements in glandular
           cardiac myxoma: Study of six cases

    • Authors: Devajit Nath, Sudheer Arava, Ruma Ray, Amol Kumar Bhoje, Rachit Saxena, Shiv Kumar Chaudhary
      Pages: 319 - 323
      Abstract: Devajit Nath, Sudheer Arava, Ruma Ray, Amol Kumar Bhoje, Rachit Saxena, Shiv Kumar Chaudhary
      Indian Journal of Pathology and Microbiology 2017 60(3):319-323
      Back ground: Glandular cardiac myxoma has varying clinical presentation with uncertain histogenesis and debatable immunohistochemical profile. Glandular epithelial differentiations are rare phenomenon known to be present as an intrinsic component of the tumor. The origin of the glands has been attributed to epithelial differentiation of a totipotent cardiomyogenic precursor cells or the entrapped foregut rests in the tumor. Materials and Methods: Retrospective study includes six cases of glandular cardiac myxoma collected over a perior of 4 years. Sections were examined to define the histogenesis, histological and immunohistochemical profile of the glandular elements. Results: Incidence of glandular cardiac myxoma was 6.6% with a male to female ratio of 1:2.Mean age was 49.9 years. Left atrium was the commonest site. Five were sporadic and one was familial. Chest pain and dyspnea were the commonest clinical symptoms. Histologically all myxoma showed well formed glandular structures with typical myxomatous area. No atypia, mitosis or necrosis was identified in the glandular elements. Markers in six cases of glandular cardiac myxoma were immunopositive for CK7, CK 19, EMA, CEA, focally for E-cadherin while immunonegative for CK20, Chromogranin, Synaptophysin, calretenin, vimentin, B-catenin, TTF-1 and GCDFP-15 favoring enteric differentiation. Conclusion: Glandular cardiac myxoma is a rare entity which shows characteristics similar to those of classical cardiac myxoma with benign glandular elements showing enteric differentiation. Complete surgical excision is the treatment of choice with good prognosis. It is important to recognize this entity to avoid an erroneous diagnosis of metastatic adenocarcinoma.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):319-323
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_225_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Correlation between human epidermal growth factor receptor 2 oncoprotein
           expression and some prognostic factors in papillary thyroid carcinoma

    • Authors: Shervin Rabiee, Mohamadreza Jalali Nadoushan, Neda Mehdizade Rayeni, Iman Ansari
      Pages: 324 - 327
      Abstract: Shervin Rabiee, Mohamadreza Jalali Nadoushan, Neda Mehdizade Rayeni, Iman Ansari
      Indian Journal of Pathology and Microbiology 2017 60(3):324-327
      Background: Thyroid cancer is one of the increasing cancer diagnoses in the United States. Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. There are a few researches done determining the role of human epidermal growth factor receptor 2 HER2 (erbB-2) in PTC prognosis. They also have been controversial. This study is designed to determine the correlation of HER2 expression with tumor size, lymph node involvement, and capsular invasion as prognostic factors. Materials and Methods: This research was a cross-sectional descriptive-analytic study. Information about age, sex, tumor size, and lymph node involvement of 85 patients undergone thyroidectomy and diagnosed PTC in Mostafa Khomeini Hospital during 2010–2012, have been derived from their medical records. Four-micron sections made from paraffin embedded blocks and HER2 expression was assessed by immunohistochemistry. Other sections were stained with H and E Method and capsular invasion was evaluated by microscope. Results: In this study, 88.2% of patients were female and 11.8% of patients were male. About 37.6% of samples were HER2 positive. There was no significant correlation between HER2 and lymph node involvement (P = 0.649), (P > 0.05). A significant correlation found between HER2 and capsular invasion (P = 0.000), (P < 0.05). This study found a significant correlation between HER2 and tumor size (P = 0.000), (P < 0.05). Conclusion: HER2 oncoprotein expression is correlated with increased tumor size and capsular invasion. Hence, HER2 can be used to assess PTC prognosis.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):324-327
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_332_15
      Issue No: Vol. 60, No. 3 (2017)
       
  • Associations between epidermal growth factor receptor and topoisomerase
           II-alpha gene copy number variations, human papillomavirus positivity, and
           cytologic analysis in cervical cell lesions

    • Authors: I&#351;&#305;n Kaya, Oya Nermin Sivrikoz, &#214;zdal Etlik, Abd&#252;lkadir G&#246;k
      Pages: 328 - 335
      Abstract: Işın Kaya, Oya Nermin Sivrikoz, Özdal Etlik, Abdülkadir Gök
      Indian Journal of Pathology and Microbiology 2017 60(3):328-335
      Background: Cervical cancer is the second most common gynecologic cancer worldwide. Human papillomavirus (HPV) infection is a leading etiological factor in cervical carcinoma.The aim of this study was to compare HPV positivity, EGFR and TOP2A gene copy number variations and cervical cytologic findings. Materials and Methods: The study group comprised 100 female volunteers between 21-64 years old. Cytologic analysis was performed using the liquid-based cytology technique. HPV DNA testing was performed in all cases. Copy number variations that belong to EGFR and TOP2A genes evaluated by using FISH analysis. Results: Cytologic analysis of the cervical samples revealed abnormal findings in 13 of the 100 study subjects. ASCUS , LSIL, HSIL were determined in 8, 2 and 3 cases respectively as the result of cytologic analysis on all cases. Forty-one (41%) of the 100 women were HPV-positive. Chi-square analysis confirmed that HPV-positive women showed significantly more abnormal cytology (P = 0.035). EGFR deletion, TOP2A deletion and both EGFR and TOP2A deletion were determined in 1, 8 and 1 cases respectively. We found no statistical difference in abnormal cytologic findings between subjects with these gene deletions and subjects with normal gene copy numbers (P > 0.05 for both). No cases of amplification were determined for either gene. Conclusion: As a result, HPV positivity and the determination of changes that may occur in the gene copy number in patients with abnormal cytology can be an important tool on account of prognosis. Research with more patients may be suggested.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):328-335
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_275_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Human immunodeficiency virus-associated cystic lymphoid hyperplasia: An
           immunohistochemical description

    • Authors: Shabnum Meer, Shailen Dulabh
      Pages: 336 - 340
      Abstract: Shabnum Meer, Shailen Dulabh
      Indian Journal of Pathology and Microbiology 2017 60(3):336-340
      Background: Cystic lymphoid hyperplasia (CLH) describes benign salivary lymphoepithelial cysts with a strong link to human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS). The pathogenesis is related to ductal dilatation of entrapped salivary elements due to intranodal HIV-associated atypical lymphoid hyperplasia. Very little is known about the immunophenotypic profile of this entity. Aim: This study aims to describe the immunopathological features of a series of CLH cases in HIV-positive patients to clarify the etiopathogenesis. Materials and Methods: Paraffin-embedded tissue from 25 cases of parotid CLH in HIV seropositive patients was immunohistochemically analyzed with CD3, CD20, CD4, CD8, and p24 using standard procedures. Statistical Analysis: The data are mostly descriptive and were analyzed using EpiInfo (3.5.1) (CDC, Atlanta, USA); significant differences were analyzed using the Student's t-test and the Chi-square test with a statistical significance level of P < 0.05 being used. Results: Immunostaining showed a CD8:CD4 of ~1:1 except in selected cases with decreased CD4 and increased CD8 expression in the interfollicular (IF) areas. p24 staining revealed 100% specificity in HIV-associated CLH. Conclusion: The immunohistochemical description of CD20, CD3, CD4, and CD8 provides an understanding of CLH pathogenesis. CLH of parotid lymph nodes in confirmed HIV-positive patients with 100% specificity with HIV p24 antibody validates the strong association of CLH with HIV and AIDS. The CD4:CD8 ratio was ~1:1; however, increased CD8 expression within IF areas may indicate possible HIV-related CLH as compared to other cystic parotid lesions.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):336-340
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_664_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Study of association of Epstein-Barr virus in lymphomas by Epstein-Barr
           virus-encoded RNA in situ hybridization: An Indian perspective from a
           tertiary care cancer institute

    • Authors: Roshani Gala, Jatin S Gandhi, Gurudutt Gupta, Shrruti K Grover, Anila Sharma, Sunil Pasricha, Anurag Mehta
      Pages: 341 - 349
      Abstract: Roshani Gala, Jatin S Gandhi, Gurudutt Gupta, Shrruti K Grover, Anila Sharma, Sunil Pasricha, Anurag Mehta
      Indian Journal of Pathology and Microbiology 2017 60(3):341-349
      Background: The Epstein-Barr virus (EBV), also called human herpesvirus 4, is a virus of the herpes family. The EBV-associated lymphomas include Burkitt lymphoma, classic Hodgkin lymphoma (HL), lymphomas arising in immunocompromised individuals, peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, extranodal nasal-type natural killer/T-cell lymphoma, and other rare histotypes. Objective: The present study evaluated the role of EBV as an etiologic agent in various lymphomas and determined an Indian perspective in a tertiary care cancer center compared to that of Western literature. Materials and Methods: Clinicopathological spectrum was studied in 184 cases of lymphomas using a standard immunohistochemistry panel and in situ hybridization for Epstein-Barr virus-encoded RNA (EBER) expression. Results and Conclusions: The prevalence of EBV was described in various HL and non-HL's and was found similar to that of Western literature. EBER expression was also observed in the nonneoplastic bystander cells in the studied cases which need further evaluation on larger scale studies.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):341-349
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_49_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Clinicopathologic features of four rare types of chordomas, confirmed by
           brachyury immunostaining

    • Authors: Bharat Rekhi, Devmalya Banerjee, Mukta Ramadwar, Jyoti Bajpai, Nirmala A Jambhekar
      Pages: 350 - 354
      Abstract: Bharat Rekhi, Devmalya Banerjee, Mukta Ramadwar, Jyoti Bajpai, Nirmala A Jambhekar
      Indian Journal of Pathology and Microbiology 2017 60(3):350-354
      Background: A wide clinicopathologic spectrum of a chordoma exists. Brachyury constitutes as its most useful diagnostic immunohistochemical (IHC) marker. Methods: During a 7-year-period, 4 unusual histopathologic types of chordomas were identified. Immunohistochemistry was performed by polymer technique. Results: Clinicopathologic features of the 4 cases are as follows: Cases 1 and 2: Two tumors occurred in the sacrococcygeal and lumbosacral regions of a 42-year-old male and a 34-year-old female, respectively. Histopathologic examination showed areas of classical chordoma; juxtaposed to a high-grade, spindle cell sarcoma. By IHC, cytokeratin (CK), epithelial membrane antigen (EMA), S-100 protein, and brachyury were found to be distinctly positive in the differentiated chordomatous areas. Both these cases were diagnosed as dedifferentiated chordomas. The first patient, postresection and adjuvant radiation therapy (RT), died after 14 months of therapy. Case 3: A 58-year-old male presented with pain in his sacral region and urinary incontinence. Imaging disclosed a sacral mass. Histopathologic examination showed physaliphorous cells intimately admixed with, markedly pleomorphic cells, scattered mitotic figures, and focal tumor necrosis. By IHC, the tumor cells were positive for CK, AE1/AE3, S-100 protein, brachyury, and INI1/SMARCB1. The diagnosis of a poorly differentiated chordoma was offered. Despite surgical resection and adjuvant RT, the patient died within 18 months. Case 4: A 58-year-old male presented with a soft tissue lesion in his left leg. Histopathologic examination showed physaliphorous cells, embedded in a myxohyaline stroma. By IHC, the tumor cells were positive for EMA, S-100 protein, brachyury, and INI1. Diagnosis of an extra-axial, soft tissue chordoma was offered. Conclusions: These four unusual chordomas, confirmed by brachyury immunoexpression, constitute as one of the first such documentation from our country, revealing a wide clinicopathologic spectrum of chordomas. Dedifferentiated and poorly differentiated chordomas are associated with an aggressive clinical course. Further diagnostic implications are discussed herewith.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):350-354
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_409_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • NPM1 and FLT3 mutations in acute myeloid leukemia with normal karyotype:
           Indian perspective

    • Authors: Sudha Sazawal, Neha Singh, Sonal Jain, Sunita Chhikara, Rekha Chaubey, Jina Bhattacharyya, Kandarpa Kr Saikia, Manoranjan Mahapatra, Renu Saxena
      Pages: 355 - 359
      Abstract: Sudha Sazawal, Neha Singh, Sonal Jain, Sunita Chhikara, Rekha Chaubey, Jina Bhattacharyya, Kandarpa Kr Saikia, Manoranjan Mahapatra, Renu Saxena
      Indian Journal of Pathology and Microbiology 2017 60(3):355-359
      Background: FLT3-ITD and NPM1 mutations are considered to be the major determinants of the patient response to therapy and outcome. The primary aim of this study was to establish the correlation between these molecular mutations and the clinico-hematologic parameters as well as the prognostic outcome of the Indian acute myeloid leukemia (AML) patients. Materials and Methods: This prospective study involved newly diagnosed nonpromyelocytic AML patients who had undergone complete diagnostic workup, including immunophenotyping, conventional cytogenetics and molecular analysis for NPM1 and FLT3-ITD mutation by reverse transcriptase polymerase chain reaction at presentation. Results: Overall, the prevalence of NPM1 and FLT3-ITD mutations was found to be 14.4% and 10.8%, respectively. Among patients with normal karyotype, leukocytosis was significantly associated with NPM1+ group than the NPM1− group (P = 0.0019) and more severe degree of anemia was observed in the FLT3-ITD+ patients than the other groups (P = 0.025). No significant correlation was found in terms of age at presentation (P = 0.56), sex ratio (P = 0.467), median platelet count (P = 0.27), and blast percentage between NPM1+ and FLT3-ITD+ groups. Complete remission (CR) rates were better in the NPM1+/FLT3-ITD− group than the other three groups. Unlike most other studies, improved CR rates as well as disease-free survival were observed in the NPM−/FLT3-ITD− group than the FLT3-ITD+ groups although not reaching statistically significant levels. Conclusion: Some differences in the clinical behavior of the Indian AML patients in comparison to that of the West in the presence of NPM1 and FLT3-ITD suggests that comprehensive studies are required to confirm the definitive role of these mutations among AML patients, especially with normal karyotype.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):355-359
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_501_15
      Issue No: Vol. 60, No. 3 (2017)
       
  • Age-related reference intervals for immunoglobulin levels and lymphocyte
           subsets in Indian children

    • Authors: Gaurav Narula, Shanaz Khodaiji, Arun Bableshwar, Manjeet Singh Bindra
      Pages: 360 - 364
      Abstract: Gaurav Narula, Shanaz Khodaiji, Arun Bableshwar, Manjeet Singh Bindra
      Indian Journal of Pathology and Microbiology 2017 60(3):360-364
      Background: In children, innate and adaptive immunity varies with age, disease status, and ethnicity, reflected by lymphocyte subsets and serum immunoglobulin (Ig) levels. The paucity of such data from the Indian subcontinent necessitated this study. Aims: This study aims to determine reference ranges of Ig and lymphocyte subsets in Indian children from birth to 5 years. Settings and Design: Neonates, infants, and children from a tertiary care hospital were selected and categorized into 5 groups from cord blood/newborn to 5 years. Materials and Methods: Samples were taken from cord blood and healthy children up to 5 years of age. Complete blood counts, serum Ig levels (by turbidimetry), and lymphocyte subsets (by flow cytometry) were studied, and reference ranges calculated. Results: Four hundred and three samples were analyzed; 53 from cord blood and 350 from children 1 month to 5 years. High IgG levels were noted at birth, which decreased in the first 6 months followed by a rise thereafter. IgM remained low in infancy and peaked at 13–36 months. IgA levels were very low at birth but increased with age. CD4 counts were high in cord blood till 3 years of age and then declined. CD8 and CD19 counts remained steady till 5 years of age. CD56 increased after the age of 2 years. Conclusions: While our data correlated well with published literature, notable differences were higher IgM levels seen in 1–3 years' age group and higher natural killer cells through all age groups in our study. Our results provide the largest database of its kind from our country.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):360-364
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_542_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Radiological tests versus pathological diagnostics: Complimentary or
           antagonistic relationship? The experience of a tertiary hospital

    • Authors: Maria A Arafah, Hala M Kfoury
      Pages: 365 - 370
      Abstract: Maria A Arafah, Hala M Kfoury
      Indian Journal of Pathology and Microbiology 2017 60(3):365-370
      Introduction: Early detection of breast cancer plays a pivotal role in the outcome of the disease. Diagnostic modalities encompass radiological and pathological findings. The aim of this study is to evaluate the correlation between the results of these two modalities in a tertiary hospital. Materials and Methods: From a total of 180 patients, 203 ultrasound-guided breast core needle biopsies (US-CNBs) were included in this study over a period of a year (May 2015 - May 2016). All clinical parameters, the site of the biopsy, the size of the needle, the radiological findings, the pathological diagnoses as well as all available follow-up data were reviewed. The concordance between the radiological and pathological results was studied and a statistical analysis conforms to the Pearson Chi-square test was applied. Results: The majority of our patients were above 40 years of age. A strong and statistically significant association was noted between radiological findings and histopathological results (Pearson's Chi-square test = 186.28, P ≤ 0.0001) with only four discordant cases (1.97%). This discrepancy was not statistically associated with age, site of biopsy, needle size, or number of cores obtained (P = 0.621, P = 0.584, P = 0.786, and P = 0.478, respectively). Conclusions: US-CNB is an accurate method in the diagnosis of breast lesions. Radiological and pathological correlation is of utmost importance in relation to patient's care and to reduce false rates. Follow-up of concordant benign lesions is essential. In addition, the importance of a multidisciplinary breast conference during which input from all teams caring for the patient is strongly emphasized.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):365-370
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_35_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Malignant phyllodes tumor with heterologous differentiation:
           Clinicopathological spectrum of nine cases in a tertiary care institute in
           Eastern India

    • Authors: Mamita Nayak, Susama Patra, Pritinanda Mishra, Nibedita Sahoo, Prakash Kumar Sasmal, Tushar Subhadarshan Mishra
      Pages: 371 - 376
      Abstract: Mamita Nayak, Susama Patra, Pritinanda Mishra, Nibedita Sahoo, Prakash Kumar Sasmal, Tushar Subhadarshan Mishra
      Indian Journal of Pathology and Microbiology 2017 60(3):371-376
      Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia. Proper diagnosis and subtyping of the sarcomatous component is essential for deciding the correct treatment modality and prognostication of the disease. However there is no clear cut treatment protocol is available because of paucity of data.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):371-376
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_426_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Superficial CD34-positive fibroblastic tumor: A new entity; case report
           and review of literature

    • Authors: Neelam Sood, Binit Kumar Khandelia
      Pages: 377 - 380
      Abstract: Neelam Sood, Binit Kumar Khandelia
      Indian Journal of Pathology and Microbiology 2017 60(3):377-380
      Earlier, categorized under low grade malignant fibrous histiocytoma and low grade sarcomas, 'superficial CD34 positive fibroblastic tumor', a newly proposed entity, is a low grade mesenchymal tumor of intermediate malignant potential. Morphological features include monomorphic neoplastic spindle cells arranged in a fascicular to storiform pattern along with sheets of pleomorphic epithelioid cells, and multinucleated giant cells with glassy cytoplasm. Diffuse vimentin and characteristic diffuse CD34 positivity is seen in all cases with few showing focal cytokeratin expression. Rest of the melanocytic and mesenchymal markers are negative. Herein, we present a case of superficial CD34-positive fibroblastic tumor in arm swelling of a 16-year-old female. Differential diagnosis of the same on the basis of morphology as well as immunohistochemistry has also been discussed. This is the first case reported from India to the best of our knowledge.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):377-380
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_589_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Meningioma with the unique coexistence of secretory and lipomatous
           components: A case report with immunohistochemical study

    • Authors: Purwa R Patil, Bhushan M Warpe, Vijay H Juvekar, Vidya Manohar
      Pages: 381 - 384
      Abstract: Purwa R Patil, Bhushan M Warpe, Vijay H Juvekar, Vidya Manohar
      Indian Journal of Pathology and Microbiology 2017 60(3):381-384
      Meningioma is the most common extra-axial neoplasm which accounts for 30% of all intracranial tumors with a female predilection. These tumors exhibit a broad spectrum of differentiation potency corresponding to different histological subtypes. Meningothelial cells can rarely show separate secretory or lipomatous (metaplastic) transformation. The coexistence of these two different histological subtypes in a single meningeal tumor is extremely rare with only two reported cases. We report an uncommon case of meningioma in a 40-year-old female showing histological admixture of both secretory and lipomatous (metaplastic) meningioma, which to our knowledge is only the third reported case in the world. It highlights the multipotency of phenotypic transformation of primary meningothelial cells. This rare tumor behaves in a fashion similar to benign meningioma of WHO Grade I type.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):381-384
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_123_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Levels of interleukins 2, 6, 8, and 10 in patients with irritable bowel
           syndrome

    • Authors: Shaileshkumar R Patel, Anshul Singh, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi, Pawan Trivedi
      Pages: 385 - 389
      Abstract: Shaileshkumar R Patel, Anshul Singh, Vatsala Misra, Sri Prakash Misra, Manisha Dwivedi, Pawan Trivedi
      Indian Journal of Pathology and Microbiology 2017 60(3):385-389
      Irritable bowel syndrome (IBS) was previously considered as a psychosomatic disorder. But recent studies indicate that inflammation plays a significant role. The present study was undertaken to evaluate role of pro-inflammatory (IL 2, IL 6 and IL 8) and anti-inflammatory (IL 10) cytokines in clinically diagnosed patients of IBS. 51 patients and 29 controls were included in this study. On the basis of history of gastrointestinal infection, patients were divided into Post Infectious (PIIBS) and Non Post Infectious (NPIIBS) groups. All subsequently underwent colonoscopy and a rectosigmoid biopsy as well as measurement of levels of IL 2, 6, 8 and 10. The levels of IL 2 and IL 8 were significantly raised in IBS patients compared to controls with the mean level of IL 2,6 and 8 higher in PIIBS group than NPIIBS group but statistically significant for IL 8 only. The mean level IL-10 was reduced in patients compared to controls but statistically insignificant. Present study shows that Interleukin levels are altered in patients suffering from IBS and may have a key role in its pathogenesis.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):385-389
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_544_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Papillary thyroid carcinoma with nodular fasciitis-like stroma: A rare
           variant with distinctive morphology

    • Authors: Kavita Mardi
      Pages: 390 - 392
      Abstract: Kavita Mardi
      Indian Journal of Pathology and Microbiology 2017 60(3):390-392
      Papillary thyroid carcinoma (PTC) is a common malignancy with multiple variants, some of which are rarely encountered in routine surgical pathology practice. PTC with exuberant nodular fasciitis-like stroma or PTC with fibromatosis-like stroma is one such variant. This tumor is characterized by an abundant stromal component with an intervening epithelial component with the typical morphologic features of PTC. We describe gross and histopathological features of this rare variant of papillary carcinoma in a 38-year-old female and review the literature. We also discuss the importance of a thorough search for epithelial components within any fibroproliferative lesion of the thyroid and address the diagnostic difficulties created by the tumor's extensive stromal component. Given the rarity of this condition, the experience gained from the present case is a useful addition to the current knowledge on disease prognostication and management.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):390-392
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_832_15
      Issue No: Vol. 60, No. 3 (2017)
       
  • Nasal angiomyolipoma: Report of two cases of an extremely rare entity

    • Authors: Mohammed Abdul Aleem, Ather Fatima, P Kumudachalam, Ramya Priyadarshini
      Pages: 393 - 395
      Abstract: Mohammed Abdul Aleem, Ather Fatima, P Kumudachalam, Ramya Priyadarshini
      Indian Journal of Pathology and Microbiology 2017 60(3):393-395
      Nasal angiomyolipoma (AML) are extremely rare tumors and so far <15 cases have been reported in the literature, and this is the first instance that Nasal AML is reported from India. We report two cases of AML arising in the nasal cavity described in 60-year-old male and 50-year-old female patient. Grossly, they were well circumscribed, lobulated masses, and microscopically, they were composed of an intimate mixture of mature fat, smooth muscle cells, and thick-walled varying sized blood vessels. Immunoexpression pattern and histopathology were characteristic. Both the patients had complete resolution of symptoms after endoscopic excision of the tumor.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):393-395
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_414_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Bilateral ovarian metastases as the presenting manifestation of lung
           carcinoid in a 50-year-old woman: Case study and review of literature

    • Authors: Subhashis Mitra, Amiya Jhunjhunwala, Hema Chakraborty
      Pages: 396 - 398
      Abstract: Subhashis Mitra, Amiya Jhunjhunwala, Hema Chakraborty
      Indian Journal of Pathology and Microbiology 2017 60(3):396-398
      Neuroendocrine tumors (NETs) are neoplasms arising from dispersed neuroendocrine cells, localized to the gastrointestinal tract (GIT), lungs, adrenal medulla, and other sites. The term “carcinoid tumor” is usually limited to NETs of the lung and GIT. Ovarian carcinoids are uncommon, accounting for 0.1% of ovarian malignancies and 5% of all NETs. Primary ovarian tumors arise in pure form or as a component of teratomas, while ovarian NET metastases are predominantly from gastrointestinal primaries. To the best of our knowledge, there are only two previous reports of bronchopulmonary carcinoids (PCs) metastasizing to the ovaries. We describe a case of PC in a 50-year-old woman, with bilateral ovarian tumors as the presenting manifestation of the disease, and discuss the clinical and pathobiologic significance of this presentation.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):396-398
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_232_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Intrapulmonary ectopic liver associated with scimitar syndrome

    • Authors: Sajna V. M. Kutty, M Lilly, Shalini Kuruvila, Sajan Koshy
      Pages: 399 - 401
      Abstract: Sajna V. M. Kutty, M Lilly, Shalini Kuruvila, Sajan Koshy
      Indian Journal of Pathology and Microbiology 2017 60(3):399-401
      We report a case of intrapulmonary ectopic liver associated with Scimitar syndrome. A two month old male child who presented with features of congestive cardiac failure underwent extensive cardiac and radiological investigations and was diagnosed with Scimitar syndrome. He was also found to have a mass in the lower lobe of the right lung, the possibilities being either a pulmonary sequestration or a diaphragmatic hernia. As his dyspnea progressively worsened, a right lower lobectomy was performed at the age of two years. Intraoperatively, no connecting pedicle or hernia sac was seen. The resected lung specimen showed a light brown mass enclosed by the lung parenchyma and microscopy showed cords of normal hepatocytes with portal tracts. The hepatocytes were positive for Hep Par1, and bile ducts were CK 7 positive. To the best of our knowledge, this is the first reported case of an intrapulmonary ectopic liver associated with Scimitar syndrome.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):399-401
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_416_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Malignant fibrous histiocytoma arising from renal capsule: An extremely
           rare entity

    • Authors: Shilpa Bairwa, Ashok Sangwaiya, Mariyam Ansari, Arpita Jindal, Sapna Singla, Ajay Yadav
      Pages: 402 - 404
      Abstract: Shilpa Bairwa, Ashok Sangwaiya, Mariyam Ansari, Arpita Jindal, Sapna Singla, Ajay Yadav
      Indian Journal of Pathology and Microbiology 2017 60(3):402-404
      Malignant fibrous histiocytoma (MFH) usually presents in the extremities or retroperitoneum. MFH arising from renal parenchyma or renal capsule is extremely rare, only few cases have been reported in literature and portend a poor prognosis. Renal MFH is differentiated from renal cell carcinoma, renal sarcoma, and sarcomatoid renal tumor only by histological and immunohistochemical studies. Since the therapeutic options for MFH are different, its early diagnosis is imperative. Herein, we report a case of a primary renal MFH in a 35-year-old male.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):402-404
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_810_15
      Issue No: Vol. 60, No. 3 (2017)
       
  • Multicentric papillary and chromophobe renal cell carcinomas in a patient
           with autosomal dominant polycystic kidney disease: Report of a rare case

    • Authors: Nibedita Sahoo, Susama Patra, Swagatika Senapati, Tushar S Mishra
      Pages: 405 - 408
      Abstract: Nibedita Sahoo, Susama Patra, Swagatika Senapati, Tushar S Mishra
      Indian Journal of Pathology and Microbiology 2017 60(3):405-408
      The causal relationship of autosomal dominant polycystic kidney disease (ADPKD) with the development of renal cell carcinoma (RCC) is still not known. We describe a case of bilateral PKD complicated with a large enhancing mass and multiple small nodules in the left kidney. The histopathological study of the nephrectomy specimen revealed the synchronous occurrence of eosinophilic variant of chromophobe RCC (EVCRCC) and multicentric papillary RCC (PRCC) in a background of ADPKD. To the best of our knowledge, this case is the first to describe the collision tumor of EVCRCC and multicentric PRCC in ADPKD.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):405-408
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_357_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Nonspecific granulomatous prostatitis in association with eosinophilic
           epithelial metaplasia and prostatic adenocarcinoma

    • Authors: Dorian I Dikov, Maria Stoyanova Koleva, Zhivko K Peshev, Veselin T Belovezhdov
      Pages: 409 - 411
      Abstract: Dorian I Dikov, Maria Stoyanova Koleva, Zhivko K Peshev, Veselin T Belovezhdov
      Indian Journal of Pathology and Microbiology 2017 60(3):409-411
      We present the first case of nonspecific granulomatous prostatitis (NSGP) associated with both eosinophilic epithelial metaplasia (EM) in benign glands and prostatic adenocarcinoma (PCa). The patient was a 68-year old man with a history of obstructive prostatic syndrome. After a transurethral resection of the prostate, the histologic analysis revealed NSGP and PCa. EM was seen in benign peri-granulomatous secretory epithelial cells as PAS Diastase positive granular eosinophilic transformation of the apical cell cytoplasm. This unusual cell appearance closely simulated the Paneth cell-like changes found in PCa. Negative chromogranin expression and weakly positive P504S immune staining in the foci of EM, surrounded by P63 positive basal cells confirmed the benign EM - phenotype. The combination of NSGP with both EM and PCa has not been reported in medical literature so far. Some observations concerning their differential diagnosis are suggested.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):409-411
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_130_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Primary classical Hodgkin lymphoma of rectum: Report of an extremely rare
           case and review of the literature

    • Authors: Jayasudha Arundhathi Vasudevan, Rekha A Nair, K Rakul Nambiar
      Pages: 412 - 414
      Abstract: Jayasudha Arundhathi Vasudevan, Rekha A Nair, K Rakul Nambiar
      Indian Journal of Pathology and Microbiology 2017 60(3):412-414
      Hodgkin lymphoma (HL) commonly presents as nodal disease, but in a subset of cases, the disease primarily develops in extranodal sites. Primary classical HL of the gastrointestinal (GI) tract is an extremely rare occurrence. Primary nature of the disease is confirmed after a complete lymphoma work up including chest radiograph, computed tomography scan, peripheral blood, and bone marrow studies. Only a few cases of primary GI lymphomas with limited immunohistochemical or molecular confirmation have been reported in literature. We report the case of a 64-year-old immunocompetent woman with primary rectal HL. She presented with constipation, and on sigmoidoscopy examination, she was detected to have an ulceroproliferative circumferential growth in the rectum. Considering the possibility of rectal carcinoma, a low anterior resection was done. Histology was suggestive of mixed cellularity classical HL. She was started on combination chemotherapy, and she responded well to treatment. However, she developed pulmonary complication after the fourth cycle of chemotherapy and succumbed to the illness. Primary rectal HL is extremely rare, and to the best of our knowledge, only 16 cases have been reported previously. We believe that reporting this case will add to the scarce data about this unusual presentation in immunocompetent patients.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):412-414
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_767_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Bilateral seminomas coexisting with adenomatoid tumor: An unusual
           occurrence

    • Authors: Suchi Mittal, Rathindra Sarangi, Sunila Jain
      Pages: 415 - 417
      Abstract: Suchi Mittal, Rathindra Sarangi, Sunila Jain
      Indian Journal of Pathology and Microbiology 2017 60(3):415-417
      Coexistence of bilateral seminomas and adenomatoid tumor is rare. We encountered an interesting case of bilateral testicular seminomas along with a paratesticular nodule which was diagnosed as an adenomatoid tumor on histology. Although seminomas and adenomatoid tumor are frequent neoplasms, bilaterality and their coexistence have been rarely described and can pose diagnostic difficulties. Herein, we describe a case of a 53-year-old man who presented with bilateral testicular swellings which were diagnosed as bilateral seminomas with an adenomatoid tumor in the left paratesticular region on histopathology. The pathological findings of these coexistent tumors and the utility of immunohistochemistry in establishing a correct diagnosis in such scenarios are discussed.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):415-417
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_871_15
      Issue No: Vol. 60, No. 3 (2017)
       
  • Malignant chondroid syringoma of thigh with late metastasis to lung: A
           very rare case report

    • Authors: Mayur Kothiya, Neha Mittal, Rajiv Kumar, Shubhada Kane
      Pages: 418 - 420
      Abstract: Mayur Kothiya, Neha Mittal, Rajiv Kumar, Shubhada Kane
      Indian Journal of Pathology and Microbiology 2017 60(3):418-420
      Mixed/biphasic tumors include epithelial-myoepithelial tumors, pleomorphic adenoma, matrix-producing tumors, cutaneous mixed tumors such as chondroid syringoma (CS), malignant mixed tumors (carcinosarcomas), pulmonary blastomas (in lung), and many others. Morphology may show overlap between various mixed tumors. At any particular site, whether these tumors are primary or metastasis from other sites is difficult to determine, more so if primary is unknown or not disclosed. CS is a rare benign mixed/biphasic skin adnexal tumor, considered as cutaneous counterpart of pleomorphic adenoma. Its malignant variant, malignant CS is reported only occasionally. We describe a case of a 51 year old female who presented with multiple masses in both lungs. This case is a very rare example of late metastasis to lungs from a primary malignant CS of thigh.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):418-420
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_322_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Undiagnosed senile systemic amyloidosis with mesenteric angiopathy leading
           to fatal outcomes: Two case series with a review of literature

    • Authors: Avneesh Gupta, Maryna Tarbunova, Anil Aggrawal, Anges E Aysola
      Pages: 421 - 423
      Abstract: Avneesh Gupta, Maryna Tarbunova, Anil Aggrawal, Anges E Aysola
      Indian Journal of Pathology and Microbiology 2017 60(3):421-423
      Amyloid mesenteric angiopathy is difficult to diagnose as gastrointestinal (GI) signs are nonspecific and radiological studies rarely identify amyloid deposits with certainty. The objective of this study was to highlight the pathological findings of amyloid mesenteric angiopathy in cases of senile systemic amyloidosis. Literature review, author's research data, and practice experience were used. Systemic amyloidosis should be considered in the differential diagnoses when evaluating nonspecific and unexplained GI in patient population aged >55 years to decrease the morbidity and fatal outcomes.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):421-423
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_278_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Incontinentia pigmenti, an x-linked dominant disorder, in a 2-year-old boy
           with Klinefelter syndrome

    • Authors: Abhilasha Williams, Laxmisha Chandrashekar, Vivi M Srivastava, Meera Thomas, Saban Horo, Renu George
      Pages: 424 - 426
      Abstract: Abhilasha Williams, Laxmisha Chandrashekar, Vivi M Srivastava, Meera Thomas, Saban Horo, Renu George
      Indian Journal of Pathology and Microbiology 2017 60(3):424-426
      Incontinentia pigmenti (IP) is a rare X-linked dominant disorder, in which skin lesions distributed along Blaschko's lines appear shortly after birth. Early lesions which are erythematous/bullous evolve over time into warty lesions, hyperpigmented swirls/macules, and atrophic hypopigmented streaks. Clinical features are heterogeneous. Abnormalities of the teeth, nails, hair, eyes, central nervous system, and breast may also be present. While intelligence is generally normal, varied degrees of intellectual disability/developmental delay have been reported. Lifespan is normal. IP is associated with mutations of the inhibitor of kappa light polypeptide gene enhancer in B cell, kinase gamma (IKBKG) gene on chromosome Xq28. This gene is involved in the activation of nuclear factor kappa B which protects cells against apoptosis; therefore, cells with IKBKG mutations are extremely susceptible to apoptosis. X-linked dominant disorders are lethal to male fetuses. Males who survive with IP either have mosaicism or an additional X chromosome (Klinefelter syndrome). We present a 22-month-old boy with IP and Klinefelter syndrome.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):424-426
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_91_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Nonpigmented strain of Chromobacterium violaceum causing neonatal
           septicemia: A rare case report

    • Authors: Shreekant Tiwari, Swetalona Pattanaik, Siba Shankar Beriha
      Pages: 427 - 429
      Abstract: Shreekant Tiwari, Swetalona Pattanaik, Siba Shankar Beriha
      Indian Journal of Pathology and Microbiology 2017 60(3):427-429
      Human infection caused by Chromobacterium violaceum is rare but has got high fatality in septicemia. Nonpigmented strains of C. violaceum have been found similar in pathogenicity to pigmented strains. Pigment production is not an exclusive character of the genus Chromobacterium because around 9%–11% strains of C. violaceum are nonpigmented. Herewith, we report a nonpigmented strain of C. violaceum from a case of neonatal septicemia that was successfully treated with gentamicin plus imipenem.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):427-429
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_479_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Metastasis within a metastasis to the thyroid: A rare phenomenon

    • Authors: Yin Ping Wong, Khairunisa Ahmad Affandi, Geok Chin Tan, Rohaizak Muhammad
      Pages: 430 - 432
      Abstract: Yin Ping Wong, Khairunisa Ahmad Affandi, Geok Chin Tan, Rohaizak Muhammad
      Indian Journal of Pathology and Microbiology 2017 60(3):430-432
      Metastatic disease involving the thyroid gland is uncommon. Solitary thyroid metastases from various primary sites particularly kidney, lung, and breast had been previously described. To the best of our knowledge, metastases from two topographically separate primary malignancies to the thyroid have never been documented hitherto. This is the first reported case of cancer-to-cancer metastasis involving an invasive breast carcinoma metastasized within a metastatic renal cell carcinoma in the nonneoplastic thyroid in a 58-year-old woman. Distinguishing a secondary thyroid metastases from a primary thyroid malignancy is utmost crucial as treatment differs. The possibility of tumor metastases from two separated primaries should always be considered in a tumor exhibiting malignant cell populations with two distinctive histomorphological appearances. The role of immunohistochemistry stains in equivocal cases cannot be overemphasized.
      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):430-432
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_287_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Fine-needle aspiration cytology of leishmanial lymphadenitis in a HIV
           reactive patient

    • Authors: Biswajit Biswas, Subrata Pal
      Pages: 433 - 434
      Abstract: Biswajit Biswas, Subrata Pal
      Indian Journal of Pathology and Microbiology 2017 60(3):433-434

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):433-434
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_626_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Primary intraosseous Rosai-Dorfman disease: Long-term follow-up with
           recurrence after surgical excision

    • Authors: Amarathunga A. H. Priyani, Samaratunga A. A. Shirani, Gamage Amila, Gunatilake W Asiri
      Pages: 435 - 436
      Abstract: Amarathunga A. H. Priyani, Samaratunga A. A. Shirani, Gamage Amila, Gunatilake W Asiri
      Indian Journal of Pathology and Microbiology 2017 60(3):435-436

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):435-436
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_509_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Leukemic phase of hepatosplenic T-cell lymphoma: A great masquerader of
           acute leukemia

    • Authors: Saniya Sharma, Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Gaurav Prakash, Neelam Varma
      Pages: 437 - 438
      Abstract: Saniya Sharma, Sreejesh Sreedharanunni, Man Updesh Singh Sachdeva, Gaurav Prakash, Neelam Varma
      Indian Journal of Pathology and Microbiology 2017 60(3):437-438

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):437-438
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_39_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Prof. M. Balaraman Nair

    • Authors: KP Aravindan
      Pages: 439 - 439
      Abstract: KP Aravindan
      Indian Journal of Pathology and Microbiology 2017 60(3):439-439

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):439-439
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/0377-4929.215403
      Issue No: Vol. 60, No. 3 (2017)
       
  • Metastasis as initial presentation of squamous cell carcinoma of
           gallbladder: A rare clinical entity

    • Authors: Pradip Kendre, Pritam Kataria, Apurva Patel, Lal Chand Mittal, Tushar Mule
      Pages: 440 - 441
      Abstract: Pradip Kendre, Pritam Kataria, Apurva Patel, Lal Chand Mittal, Tushar Mule
      Indian Journal of Pathology and Microbiology 2017 60(3):440-441

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):440-441
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_113_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Pacemaker lead infective endocarditis in immunocompetent host due to
           Aspergillus: An uncommon occurrence

    • Authors: Aminder Singh, Abhishek Goyal, Bhupinder Singh, Neena Sood
      Pages: 441 - 442
      Abstract: Aminder Singh, Abhishek Goyal, Bhupinder Singh, Neena Sood
      Indian Journal of Pathology and Microbiology 2017 60(3):441-442

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):441-442
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_257_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Immunoglobulin G4-related orbital disease: An important differential
           diagnosis for orbital swellings with lymphoplasmacytic infiltration

    • Authors: Samrat Bordoloi, Jayaram Iyengar
      Pages: 443 - 444
      Abstract: Samrat Bordoloi, Jayaram Iyengar
      Indian Journal of Pathology and Microbiology 2017 60(3):443-444

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):443-444
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_476_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Subcutaneous cysticercosis and cytological findings

    • Authors: Beuy Joob, Viroj Wiwanitkit
      Pages: 445 - 445
      Abstract: Beuy Joob, Viroj Wiwanitkit
      Indian Journal of Pathology and Microbiology 2017 60(3):445-445

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):445-445
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_389_17
      Issue No: Vol. 60, No. 3 (2017)
       
  • Megakaryocytic blast crisis in chronic myeloid leukemia: A primary
           presentation

    • Authors: Komal Mahendra Ashar, Viren Vaghasiya, Smita Chetan Patel
      Pages: 445 - 447
      Abstract: Komal Mahendra Ashar, Viren Vaghasiya, Smita Chetan Patel
      Indian Journal of Pathology and Microbiology 2017 60(3):445-447

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):445-447
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_841_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • The expression of interleukin-17 in cutaneous lesions of lupus
           erythematosus in pediatric-onset systemic lupus erythematosus

    • Authors: Govind Suresh Mittal, Sathish Kumar, Meera Thomas, Visali Jeyaseelan, Renu George
      Pages: 447 - 448
      Abstract: Govind Suresh Mittal, Sathish Kumar, Meera Thomas, Visali Jeyaseelan, Renu George
      Indian Journal of Pathology and Microbiology 2017 60(3):447-448

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):447-448
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_655_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Effect of processing time on analysis of rare event in minimal residual
           disease study

    • Authors: Sandeep Rai, Uma Bhardwaj, Saroj Singh, Aroonima Misra
      Pages: 449 - 451
      Abstract: Sandeep Rai, Uma Bhardwaj, Saroj Singh, Aroonima Misra
      Indian Journal of Pathology and Microbiology 2017 60(3):449-451

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):449-451
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_353_16
      Issue No: Vol. 60, No. 3 (2017)
       
  • Helicobacter pylori prevalence and relation with obesity

    • Authors: Saime Hacer Ozdemir, &#199;agr&#305; Aksu, Ebru Ozden, Irem Narman, Seda Varlik, Burak Aksu, Ozgur Kasimay, Aysegul Karahasan Yagci
      Pages: 451 - 452
      Abstract: Saime Hacer Ozdemir, Çagrı Aksu, Ebru Ozden, Irem Narman, Seda Varlik, Burak Aksu, Ozgur Kasimay, Aysegul Karahasan Yagci
      Indian Journal of Pathology and Microbiology 2017 60(3):451-452

      Citation: Indian Journal of Pathology and Microbiology 2017 60(3):451-452
      PubDate: Fri,22 Sep 2017
      DOI: 10.4103/IJPM.IJPM_374_16
      Issue No: Vol. 60, No. 3 (2017)
       
 
 
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