for Journals by Title or ISSN
for Articles by Keywords
Journal Cover JAMA The Journal of the American Medical Association
  [SJR: 6.44]   [H-I: 549]   [1694 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0098-7484 - ISSN (Online) 1538-3598
   Published by American Medical Association Homepage  [13 journals]
  • Highlights for March 6, 2018
    • PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • What Clinicians Need to Know About Vitamins and Mineral Supplements
    • Authors: Manson JE; Bassuk SS.
      Abstract: This Viewpoint reviews the evidence supporting use of specific vitamin and mineral supplements in healthy and high-risk populations, and provides general guidance about appropriate and inappropriate use of such supplements in generally healthy people.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Adverse Health Consequences of the International Retreat From Human Rights
    • Authors: Lohman D.
      Abstract: This Viewpoint argues that a rise in attacks on health care facilities internationally is associated with the rise of authoritarian and far-right leaders, a general deterioration in mechanisms of domestic accountability, and a retreat of the international community from holding member governments accountable for adhering to basic human rights standards.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • The Importance of Contact Precautions for Endemic MRSA and VRE
    • Authors: Rubin MA; Samore MH, Harris AD.
      Abstract: This Viewpoint discusses the importance of using gloves and gowns when caring for patients with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci despite the current lack of a strong clinical trial evidence base to support the practice.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Legal Challenges to State Drug Pricing Laws
    • Authors: Lee TT; Kesselheim AS, Kapczynski A.
      Abstract: This Viewpoint discusses legislative efforts at the state level to monitor or regulate drug prices and reviews legal challenges raised by industry in response to these efforts.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Finding Meaning in Death and Life
    • Authors: Baldor DJ.
      Abstract: When confronted with an infant with extreme microcephaly, the author in this essay remembers the life of a childhood friend’s older brother and idol who died overdosing inhalants at boarding school and resolves to trick the universe by adding more time for loved ones, patients, and colleagues.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Screening for Prostate Cancer
    • Authors: Barry MJ.
      Abstract: In this issue of JAMA, Martin and colleagues report the results of the third, and with more than 400 000 participants by far the largest, randomized trial of prostate-specific antigen (PSA) screening for prostate cancer. The Cluster Randomized Trial of PSA Testing for Prostate Cancer (CAP) joins the US Prostate, Lung, Colorectal, and Ovarian Cancer Screening (PLCO) trial (about 77 000 participants) and the European Randomized Study of Screening for Prostate Cancer (ERSPC) trial (about 162 000 participants) in attempting to settle the question of the balance of benefits and harms from PSA screening. In this cluster randomized trial, 573 primary care practices in the United Kingdom offered men aged 50 to 59 years a single PSA screening test or usual care. The mean age of the 419 582 participants was 59 years and about 40% of the participants treated at the practices randomized to the intervention group accepted the invitation to be screened, a degree of dilution of the intervention consistent with the prediction of screening uptake included in the trial’s power calculation.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Safety of Multiple Antigen Exposure in the Childhood Immunization Schedule
    • Authors: O’Leary ST; Maldonado YA.
      Abstract: In 2013, the Institute of Medicine (IOM), now the National Academy of Medicine, called for increased research into the safety of the entire childhood immunization schedule. Although pre- and postlicensure studies had examined the safety and efficacy of individual vaccines separately and in combination with other vaccines, these studies did not examine the safety of the overall schedule. In addition, the overall immunization schedule had evolved to include increased numbers of routine vaccinations, from 8 in 1994 to 14 in 2010. Parents were also concerned about the possible safety of increased vaccine antigens administered to their children over time. A survey from the late 1990s (N = 1600) showed that 25% of parents thought that too many vaccines weaken a child’s immune system and 23% thought children get more vaccines than are good for them. Those concerns increased with time, and “too many too soon” became a common refrain among antivaccine groups. Pressure from antivaccine groups played no small role in shaping the IOM’s recommendation to study the overall schedule. The IOM report stated “parents and health care professionals would benefit from more comprehensive and detailed information with which to address parental concerns about the safety of the immunization schedule.”
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Opioid vs Nonopioid Medications on Pain-Related Function
    • Authors: Krebs EE; Gravely A, Nugent S, et al.
      Abstract: This randomized clinical trial compares the effects of opioid vs nonopioid medications over 12 months on pain-related function, pain intensity, and adverse effects among Veterans Affairs patients with moderate to severe chronic back pain or hip or knee osteoarthritis pain.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Effect of 1-Time PSA Screening on Prostate Cancer Mortality
    • Authors: Martin RM; Donovan JL, Turner EL, et al.
      Abstract: This cluster randomized trial evaluates the effect of a single prostate-specific antigen (PSA) screening test on 10-year prostate cancer–specific mortality among men aged 50 to 69 years treated at UK primary care practices.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Disease Progression and Mortality in Gleason 9-10 Prostate Cancer After
           Definitive Treatment
    • Authors: Kishan AU; Cook RR, Ciezki JP, et al.
      Abstract: This cohort study compares mortality and disease progression in patients with Gleason score 9-10 (aggressive) prostate cancer treated with external beam radiotherapy plus androgen deprivation therapy, radiotherapy plus brachytherapy boost, or radical prostatectomy.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Cumulative Vaccine Antigen Exposure in Children With and Without
           Non–Vaccine-Targeted Infections
    • Authors: Glanz JM; Newcomer SR, Daley MF, et al.
      Abstract: This nested case-control study compares cumulative vaccine antigen exposure through the first 23 months of life among children with vs without non–vaccine-targeted infections between 24 and 47 months of age.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Diagnosis and Management of Thyroid Nodules
    • Authors: Durante C; Grani G, Lamartina L, et al.
      Abstract: This Narrative Review article reports on the clinical management of patients with thyroid nodules.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Procalcitonin Testing to Guide Antibiotic Therapy in Acute Upper and Lower
           Respiratory Tract Infections
    • Authors: Schuetz P; Wirz Y, Mueller B.
      Abstract: This Clinical Evidence Synopsis summarizes a 2017 Cochrane review on procalcitonin testing to guide antibiotic therapy for patients with acute upper and lower respiratory tract infections.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Peanut Allergy Prevention
    • Authors: Volerman A; Cifu AS.
      Abstract: This JAMA Clinical Guidelines Synopsis summarizes the 2016 National Institute of Allergy and Infectious Diseases guideline on peanut allergy prevention among infants.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Characteristics of Hospitals Rewarded in CMS’ Bundled Payment CJR
    • Authors: Navathe AS; Liao JM, Shah Y, et al.
      Abstract: This study uses Medicare data to compare the characteristics of hospitals that did vs did not realize episodes savings under the Centers for Medicare & Medicaid Services’ Comprehensive Care for Joint Replacement program, which bundled payments for hip and knee surgery and paid bonuses to hospitals that exceeded quality and cost benchmarks.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Effect of Titrated vs Low Positive End-Expiratory Pressure on Mortality in
    • Authors: McKown AC; Semler MW, Rice TW.
      Abstract: To the Editor The trial by the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators compared a low positive end-expiratory pressure (PEEP) strategy with one combining a recruitment maneuver and PEEP titration personalized to respiratory system compliance among adults with moderate to severe acute respiratory distress syndrome (ARDS). The recruitment maneuver and personalized PEEP approach lowered driving pressure but increased mortality. Although one potential explanation for increased mortality is the negative effects of the recruitment maneuver, another is ventilator-induced lung injury from overdistension of alveoli at end-inspiration (tidal hyperinflation) resulting from the method of personalizing PEEP.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Effect of Titrated vs Low Positive End-Expiratory Pressure on Mortality in
    • Authors: Barbas C; Nemer S.
      Abstract: To the Editor In a systematic review and meta-analysis of 2299 patients with moderate or severe ARDS, lower mortality was found in the high-PEEP group compared with the low-PEEP group (34.1% vs 39.1%, respectively; P = .049). In a second systematic review and meta-analysis of 1594 patients with ARDS, alveolar recruitment maneuvers were associated with reduced in-hospital mortality without increasing the risk of adverse events. In addition, a multicenter, randomized clinical trial of 200 patients with moderate to severe ARDS showed that an open-lung approach improved oxygenation and driving pressure, without detrimental effects on mortality, ventilator-free days, or barotrauma.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Effect of Titrated vs Low Positive End-Expiratory Pressure on Mortality in
    • Authors: Morris IS; Lane AS, Seppelt I.
      Abstract: To the Editor The ART investigators performed a multicenter randomized clinical trial comparing a high-PEEP strategy using lung recruitment with titrated PEEP vs a low-PEEP strategy in patients with ARDS. The trial, however, still leaves unanswered questions.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Effect of Titrated vs Low Positive End-Expiratory Pressure on Mortality in
    • Authors: Cavalcanti A; Amato M, Ribeiro de Carvalho C.
      Abstract: In Reply Dr McKown and colleagues suggest that the method used to personalize PEEP might be one explanation for the higher mortality in the recruitment maneuver and PEEP titration group. When multiple PEEP levels had similar compliance, we set the PEEP at 2 cm above the highest of these levels based on observations from a previous case series. Mean PEEP levels used in the experimental group were similar to other high-PEEP trials. We also used a tidal volume of 5 mL/kg predicted body weight during PEEP titration, although tidal volume was set at 6 mL/kg during maintenance ventilation (or lower if plateau pressure >30 cm H2O). We acknowledge that using the same tidal volume both during PEEP titration and maintenance ventilation would have been a better choice, although the small differences between tidal volume during PEEP titration and maintenance ventilation were unlikely to substantially change the level of optimal PEEP.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Patient Data Ownership
    • Authors: Contreras JL; Rumbold J, Pierscionek B.
      Abstract: To the Editor The Viewpoint by Ms Mikk and colleagues aimed to improve patient engagement and health care informatics and to recommend technical improvements to electronic health care records. The authors proposed a data use agreement (DUA) that relates to data quality, integrity, privacy, and security. Our principal concern is with the use of such a DUA to grant patients control over all uses of health data, including in secondary research. This measure of control is apparently what the authors referred to as “patient data ownership” in their title, although the term was not used in the body of the article.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Patient Data Ownership—Reply
    • Authors: Mikk KA; Sleeper HA, Topol E.
      Abstract: In Reply Mr Contreras and colleagues express concern that providing individuals with control over their complete, longitudinal health data could result in less-effective scientific research because individuals may not choose to share their data. However, multiple studies have shown that individuals are far more willing to share their medical data for research purposes than are their physicians.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Clinicians Support Medical Marijuana Use in Children With Cancer
    • Authors: Peachman R.
      Abstract: This Medical News story discusses clinician attitudes towards medical marijuana use in children with cancer, and gaps in knowledge that pose barriers to its use in the clinic.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • β-Blockers After a Heart Attack
    • Authors: Abbasi J.
      Abstract: This Medical News article discusses whether all patients really need β-blockers after a heart attack.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Scientists Separate Opioids’ Analgesic Effects From Their
           Respiratory Effects
    • Authors: Hampton T.
      Abstract: This Medical News article discusses recent research findings that disentangles opioids analgesic effects from their dangerous respiratory effects.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Crackdown on Opioid Cessation Products
    • Authors: Voelker R.
      Abstract: The FDA and the Federal Trade Commission (FTC) have warned companies that market any of 12 unapproved opioid cessation products that their claims to treat opioid misuse disorder or withdrawal symptoms are illegal.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Radioactive Drug for Adults With Rare Cancer
    • Authors: Voelker R.
      Abstract: The first radioactive drug has been approved for adults with rare cancers known as gastroenteropancreatic neuroendocrine tumors (GEP-NETs). Lutetium-177 (177Lu)–Dotatate is indicated for patients whose tumors are somatostatin receptor-positive.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Scrutiny on Animal Research
    • Authors: Voelker R.
      Abstract: The FDA is taking steps to address concerns about its animal research program after 4 squirrel monkeys died during a study examining the behavioral and biological effects of nicotine, according to a statement from FDA Commissioner Scott Gottlieb, MD.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • A Review of The American Mercy Tour
    • Authors: Muth CC.
      Abstract: This Arts and Medicine reviews The American Mercy Tour, a traveling 2-act 1-man show created by Michael Milligan that dramatizes the stresses experienced by primary care physicians and patients in the US health care system.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Umbria Shook Today
    • Authors: Pucciani D.
      Abstract: But now is at rest. The ceilingis still above us, the ground below.I heard a guttural groan as earthshed humans like fleas, their homes,their churches, their idle pursuits. But
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • The Health of Women Wage Earners
    • Abstract: The entrance of women into vocations once regarded as the exclusive province of male labor has been enormously accentuated by the needs of wartime service throughout the world, although the movement in this direction was well initiated in some fields even before the present conflict. Most civilized countries have provided special legislative protection for women wage earners. It is said that in many respects American legislation lags far behind the legal protection already afforded by leading European countries to the women who, with slighter physique, are competing with men or are replacing men amid the special health hazards of modern industry.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • Anaphylaxis in Children
    • Authors: Baiu I; Melendez E.
      Abstract: This JAMA Patient Page discusses anaphylaxis symptoms, treatment, and avoidance measures in children.
      PubDate: Tue, 06 Mar 2018 00:00:00 GMT
  • JAMA
    • PubDate: Tue, 06 Mar 2018 00:00:00 GMT
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
Home (Search)
Subjects A-Z
Publishers A-Z
Your IP address:
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-