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Journal Cover JAMA The Journal of the American Medical Association
  [SJR: 6.44]   [H-I: 549]   [1329 followers]  Follow
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 0098-7484 - ISSN (Online) 1538-3598
   Published by American Medical Association Homepage  [13 journals]
  • Highlights for February 21, 2017
    • PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Improving Lower Extremity Functioning in Peripheral Artery Disease
    • Authors: McGrae McDermott M; Kibbe MR.
      Abstract: This Viewpoint reviews treatment options to improve walking ability and quality of life for patients with lower extremity peripheral artery disease.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Emerging and Re-emerging Infectious Diseases
    • Authors: Paules CI; Fauci AS.
      Abstract: This Viewpoint discusses the importance of continuing infectious diseases research, even after outbreaks subside and disease progression becomes endemic.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Balancing Benefit and Risk at the US Food and Drug Administration
    • Authors: Califf RM.
      Abstract: This Viewpoint from former US FDA Commissioner Robert Califf discusses existing agency decision support tools for assessing the benefits and risks of medical products under review and the advantages of harmonizing the currently separate frameworks used for evaluating devices and for drugs and biologics.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Mental Illness–Incarceration-Recidivism Cycle
    • Authors: Hirschtritt ME; Binder RL.
      Abstract: This Viewpoint offers ways people with serious mental illness can be diverted from prison by preventing court involvment, developing mental health courts, mandating police training, providing housing, and developing outpatient treatment progams.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Rosemary’s Gifts
    • Authors: Stead W.
      Abstract: I find the poinsettia in a basket at my front door and bring it inside. I read the card: “Merry Christmas, Doctor. Love, Rosemary and Jim.” My 10-year-old son is eating breakfast at our kitchen table. “Who sent the flowers'” he asks.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Testosterone and Male Aging
    • Authors: Handelsman DJ.
      Abstract: Hopes for hormonal rejuvenation appear periodically throughout history—with the most prominent attempt occurring around the turn of the 20th century only to vanish in the 1930s following the discovery of testosterone, which discredited testis extracts and manipulations. In recent decades, there has been a renewed attempt for hormonal rejuvenation with testosterone in men.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • When and How to Treat Subthreshold Depression
    • Authors: Kroenke K.
      Abstract: Depressive disorders are present in about 10% of primary care patients and account for more years lived with disability than any single disease. Nearly three-quarters of all outpatient visits for depression are to primary care clinicians rather than to mental health specialists. Collaborative care is a therapeutic intervention in which behavioral health is integrated into primary care, most commonly using a nurse care manager to monitor depressive symptoms in depressed patients and adjust treatment under the supervision of a psychiatrist. Many of the nurse contacts are conducted by telephone, thereby increasing the efficiency of collaborative care. Although collaborative care has been demonstrated to improve depression in more than 80 randomized clinical trials, most trials have targeted major depression.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Useful vs Misleading Evidence in Observational Research
    • Authors: Goodman SN; Schneeweiss S, Baiocchi M.
      Abstract: Few issues can be more important to physicians or patients than that treatment decisions are based on reliable information about benefits and harms. While randomized clinical trials (RCTs) are generally regarded as the most valid source of evidence about benefits and some harms, concerns about their generalizability, costs, and heterogeneity of treatment effects have led to the search for other sources of information to augment or possibly replace trials. This is embodied in the recently passed 21st Century Cures Act, which mandates that the US Food and Drug Administration develop rules for the use of “real world evidence” in drug approval, defined as “data…derived from sources other than randomized clinical trials.” A second push toward the use of nontrial evidence is based on the perception that the torrent of electronic health-related data—medical record, genomic, and lifestyle (ie, “Big Data”)—can be transformed into reliable evidence with the use of powerful modern analytic tools.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Testosterone Treatment and Coronary Artery Plaque Volume in Men With Low
    • Authors: Budoff MJ; Ellenberg SS, Lewis CE, et al.
      Abstract: This clinical trial compares the effects of testosterone gel vs placebo for 12 months on noncalcified coronary artery plaque volume in older men with low testosterone.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Testosterone Treatment and Cognitive Function in Men With Memory
    • Authors: Resnick SM; Matsumoto AM, Stephens-Shields AJ, et al.
      Abstract: This randomized trial compares the effects of testosterone gel vs placebo for 12 months on verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Effect of Collaborative Care on Depressive Symptoms in Older Adults
    • Authors: Gilbody S; Lewis H, Adamson J, et al.
      Abstract: This randomized clinical trial investigates whether a collaborative care intervention, compared with usual care, reduces depressive symptoms and prevents more severe depression in older people with subclinical depression.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Effect of Fibrinogen Concentrate on Intraoperative Blood Loss During
           Cardiac Surgery
    • Authors: Bilecen S; de Groot JH, Kalkman CJ, et al.
      Abstract: This randomized trial compares the effects of fibrinogen concentrate vs placebo on intraoperative blood loss in patients at high-risk of bleeding undergoing elective cardiac surgery.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Adjusted Analyses in Studies Addressing Therapy and Harm
    • Authors: Agoritsas T; Merglen A, Shah ND, et al.
      Abstract: This Users’ Guide to the Medical Literature discusses strategies for adjusting analyses as a way of addressing prognostic imbalance in studies of therapy and harm.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Cellulitis: Commonly Misdiagnosed and Misunderstood
    • Authors: Moran GJ; Talan DA.
      Abstract: This commentary discusses a cross-sectional study published in JAMA Dermatology reporting frequent misdiagnosis of lower extremity cellulitis and characterizing the patient and health service complications of the misdiagnosed infection.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Management of Chronic Insomnia in Adults
    • Authors: Medalie L; Cifu AS.
      Abstract: This JAMA Clinical Guidelines Synopsis summarizes the American College of Physicians’ 2016 guideline on management of chronic insomnia in adults.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Website Characteristics and Physician Reviews on Physician-Rating Websites
    • Authors: Lagu T; Metayer K, Moran M, et al.
      Abstract: This study characterizes the type and number of physician reviews on commercial physician-rating websites.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Substance Use Terminology
    • Authors: Calver KE; Saitz R.
      Abstract: To the Editor We share the concerns of the authors of a Viewpoint about the prevalent use of stigmatizing language to refer to unhealthy substance use and the people afflicted by it. Movements at the national level are occurring to encourage the use of nonstigmatizing language, such as the addiction terminology statement by the International Society of Addiction Journal Editors, which marks an important step in developing a consensus on stigmatizing language among medical journals worldwide. In particular, it discourages the use of “dirty,” “clean,” “abuse,” and “abuser.”
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Substance Use Terminology
    • Authors: Moser C.
      Abstract: To the Editor Mr Botticelli and Dr Koh focused on the need to change the language of addiction to help frame the illness accurately and avoid judgments. Unfortunately, the authors used a term that has negative implications, a propensity to be misinterpreted, is poorly defined, does not reflect the current science, and does not promote evidence-based medicine. That term is addiction. If it is inappropriate to refer to a person as a substance abuser, rather than as a person with a substance use disorder, they should not be referred to as addicts either.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Substance Use Terminology
    • Authors: Barnett AI; Hall W, Carter A.
      Abstract: To the Editor A Viewpoint drew attention to the potential stigmatizing effects of language used by health professionals to describe individuals with substance use disorders. The authors argued that scientific evidence demonstrates that drug addiction is a “chronic brain disorder with potential for recurrence” and cited the White House Office of National Drug Control Policy document entitled “Changing the Language of Addiction,” which encourages clinicians to replace commonly stigmatizing terms (eg, substance abuser) with “alternative language more aligned with science.” They argued that this change will reduce stigma, lead to less isolation, and encourage treatment seeking.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Substance Use Terminology
    • Authors: Koh HK.
      Abstract: In Reply The comments in response to our Viewpoint join many others that have been received as part of the recently completed public comment process in response to the draft federal document “Changing the Language of Addiction.”
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Evidence for the Baby-Friendly Hospital Initiative to Support
    • Authors: Bartick MC; Nickel NC, Hanley LE.
      Abstract: To the Editor The Editorial by Drs Flaherman and Von Kohorn accompanying the US Preventive Services Task Force (USPSTF) recommendation on primary care interventions to support breastfeeding asserted that systemic interventions such as the Baby-Friendly Hospital Initiative (BFHI) “should be reconsidered until good-quality evidence emerges that these interventions are safe and effective.”
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Evidence for the Baby-Friendly Hospital Initiative to Support
    • Authors: Flaherman V; Von Kohorn I.
      Abstract: In Reply As Dr Bartick and colleagues point out, although the USPSTF review did not find evidence to support the BFHI, many scientific studies that were excluded from the USPSTF review have reported a strong association between the BFHI and improved breastfeeding outcomes, particularly PROBIT, conducted in Belarus from 1996-1997.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Evidence for the Baby-Friendly Hospital Initiative to Support
    • Authors: Patnode CD; Senger CA.
      Abstract: In Reply Dr Bartick and colleagues point out a key limitation of our review methodology, which was discussed at length in both our full report and article. We set a priori eligibility criteria limiting included study designs to randomized clinical trials, prospective cohort studies, and before-and-after designs with concurrent control groups. There are a number of published evaluations of the BHFI (and other systems-level policies and practices), but they are generally limited to before-after comparisons within single hospitals or ecological studies and thus were excluded from our review. Although these types of study designs can enhance understanding of the relationship between policy implementation and rates of breastfeeding and can suggest avenues of further research, these designs cannot demonstrate causal associations and are often confounded by other important variables such as changes in the underlying population and rates of breastfeeding, other maternity care practices, and the measurement of breastfeeding. Although we agree that randomization of birthing facilities to receive or not receive BFHI accreditation would be logistically and perhaps ethically challenging, more studies using longitudinal, controlled designs that perhaps take advantage of so-called natural experiments are warranted.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Adapting High-Tech Medicine to Third World
    • Authors: Lyon J.
      Abstract: This Medical News article is an interview with Rebecca Richards-Kortum, winner of a MacArthur Fellowship for her work in global health.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • How Will President Trump’s Policies Affect Domestic and Global
           Health and Development'
    • Authors: Gostin LO.
      Abstract: Donald Trump’s election to the US presidency marks a time of global transition, with singular importance to health. The world is witnessing the rise of populist movements characterized by concerns about trade, immigration, globalization, and international organizations. These seismic events could have profound effects on health and development in the United States and globally.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Genetic Variants of Parasites Linked to Unusual Forms of Leishmaniasis
    • Authors: Friedrich MJ.
      Abstract: Cases of atypical cutaneous leishmaniasis (ACL) occurring in Brazil appear to be caused by genetically distinct strains of Leishmania braziliensis, according to a report from a team of investigators from Brazil and the United States.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Ebola Vaccine Found Highly Protective
    • Authors: Friedrich MJ.
      Abstract: A single dose of the experimental Ebola vaccine, rVSV-ZEBOV, was highly effective in preventing Ebola virus disease (EVD) among those in contact with patients with confirmed disease, according to the final results from a large trial conducted in Guinea.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Uneven Progress in Preventing and Treating HIV Worldwide
    • Authors: Friedrich MJ.
      Abstract: Despite the progress over the last 3 decades made toward ending the global AIDS epidemic, a greater focus on preventing and treating the disease in children in countries with high HIV prevalence is critical, according to the report released by the United Nations Children’s Fund (UNICEF), For Every Child: End AIDS.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Contamination in Drug Compounding Facilities
    • Authors: Voelker R.
      Abstract: Since 2013 when Congress amended the Federal Food, Drug, and Cosmetic Act to address serious safety issues surrounding compounded drugs, the FDA has inspected hundreds of facilities and issued dozens of warnings to protect consumers from contaminated compounded products.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Novel Drugs Passed Muster in 2016
    • Authors: Voelker R.
      Abstract: During 2016, the FDA’s Center for Drug Evaluation and Research (CDER) approved 22 novel drugs—new molecular entities or therapeutic biologics—that serve unmet medical needs or significantly advance patient care and public health.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Scientists Cited for Meningitis Vaccine Work
    • Authors: Voelker R.
      Abstract: Two FDA scientists have received the US Patent and Trademark Office’s Patents for Humanity Award for their work in developing a meningitis vaccine used in sub-Saharan Africa.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Moving the Needle on Recovery From Breast Cancer
    • Authors: Allen D.
      Abstract: This Arts and Medicine essays reports the experience of Chicago-based tattoo artist David Allen, whose work with women to design imagery to conceal their mastectomy scars helps them reclaim a sense of control over their bodies.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Tale of Two Livers
    • Authors: Wallace D.
      Abstract: Two sets of lemon-tinted eyes staringBack at me from adjacent hospital bedsNumbers interchangeable, characters distinct.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Communication and the Journals
    • Abstract: Do medical journals aid communication' Although most persons would consider the answer self-evident, some apparently disagree. For example, last April 4-6, a symposium on Biomedical Communications was held in New York City. The New York Academy of Sciences and the Audiovisual Facility of the USPHS sponsored the event. Among its distinguished list of speakers we look in vain for a medical editor; nor does the agenda contain any hint that medical journalism has a role in medical communication.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • Restless Legs Syndrome
    • Authors: Muth CC.
      PubDate: Tue, 21 Feb 2017 00:00:00 GMT
  • JAMA
    • PubDate: Tue, 21 Feb 2017 00:00:00 GMT
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