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Medical Journal of Ankara Training and Research Hospital
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Online) 1304-6187
Published by Ankara Eğitim ve Araştırma Hastanesi Homepage  [1 journal]
  • Prognostic Value of Preoperative CRP and IL-6 Levels in Gastric Carcinoma

    • Authors: Buket ALTUN ÖZDEMİR ; Havva Belma KOÇER , Mustafa BALCI
      Abstract: Objective: Interleukin-6 (IL-6) plays a role in pathways in inflammation and angiogenesis in tumor formation. C-reactive protein (CRP) is a marker of inflamation and accompanies the progression of many cancers.In this study, the effect of preoperative CRP and IL-6 levels on the prognosis of patients with gastric cancer was investigated.Materials and Methods: Forty-five patients who underwent elective surgery for gastric cancer in our clinic between January 2002 and April 2004 were included in the study. Demographic, histopathological and clinical characteristics of the patients were evaluated. CRP and IL-6 levels were measured in preoperative blood samples.Results: IL-6 levels were significantly correlated with preoperative metastasis, mortality, and CRP levels. Factors affecting CRP levels were preoperative and postoperative metastasis, mortality, CEA, and IL-6. Multivariate analysis showed that CRP elevation increased IL-6 levels independently of other factors. Factors affecting disease-free survival were; CA 19-9, IL-6, CRP, differentiation, tumor stage, Lauren classification, and presence of preoperative metastasis. Factors affecting total survival were; IL-6, CRP, CEA elevation, differentiation, stage, wall invasion thickness, presence of diffuse type in Lauren classification, presence of lymphatic invasion, presence of preoperative metastasis, and chemotherapy treatment.Conclusion: Measurement of preoperative serum CRP and IL-6 levels in gastric cancer reflects the malignant potential and progression of the disease. Therefore, they can be used as useful tumor markers in monitoring patients and monitoring their response to treatment.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030

    • Authors: Ayhan COŞGUN
      Abstract: Purpose: New inflammatory markers have recently been proposed for chronic inflammatory diseases. Inflammation plays an important role in the pathogenesis of stable coronary artery disease(SCAD). The aim of our study was to evaluate hematological parameters in elderly male patients with SCAD.Material and Methods: Between March 2015 and August 2019, 131 male patients over 65 years of age who had exertion angina for 3 months and had 3 vascular disease on coronary angiography and had an ejection fraction (EF) of less than 55% on transthoracic echocardiogram were included in the study group 1. A total of 117 male patients over 65 years of age who had exertion angina more than 3 months and 3-vessel disease on coronary angiography and whose EF was above 55% on transthoracic echocardiogram were included in the study. Data of elderly male patients were recorded from the patient files of the institution. The data of the two study groups were compared.Results: In group 1, Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV)/Platelet (P) and RDW/P values were significantly higher than group 2 (p
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
  • Developmental profile of toddlers with autism spectrum disorder at a
           tertiary centre in Turkey

    • Authors: Pelin ÇELİK ; İclal AYRANCİ SUCAKLİ , Gülser ŞENSES DİNÇ , Halil İbrahim YAKUT
      Abstract: Purpose: The aim of the study was to examine the clinical and developmental characteristics of toddlers with autism spectrum disorder (ASD); and find out early manifestations.Material and method: Medical records of 134 newly diagnosed children under 4 years of age and followed by both developmental-behavioral pediatrics, and child and adolescent psychiatry between January 2017 and May 2019 were retrospectively reviewed. Developmental features of children who diagnosed ≤24 months of age and later were compared.Results: ASD diagnosis was performed at ≤24 and >24 months of age in 43 (32.1%) and 91 (67.9%) children, respectively. The most common concern expressed by parents at admission was language delay (46.2%). While only 1.5% of parents named “autism” spontaneously as a concern, 73.9% of parents expressed concerns about ASD when the history was deepened. Parental concern about ASD (p=0.031) and mother’s education level ≥8 years (p=0.002) were associated with earlier diagnosis. Children diagnosed at ≤24 months of age were more likely to have inability to follow verbal commands (p=0.012) and delayed motor milestones (p=0.008). Other ASD signs and clinical characteristics were similar between children who diagnosed at ≤24 and >24 months of age.Conclusion: The signs of ASD emerge over the first 2 years of life. Children who diagnosed ASD ≤24 months of age have poorer receptive language and motor skills. Whereas parents were recognising warming signs of ASD, they may not express their concerns clearly. Pediatricians should take time to listen to parents and realize their concerns reflecting ASD.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
  • Does being a Health Worker Have an Effect on Breast Cancer Awareness'

    • Authors: Gül BORA MAKAL
      Abstract: AIM:The purpose of this study to measure the breast cancer knowledge levels ofwomen health workers and to investigate the factors that determine the beliefs,attitudes, and behaviors against screening methods.MATERIAL AND METHODS: This study wasconducted on 850 volunteer participant women over 21 years old, healtheducated, uneducated, and other members of the community. Ethical committeeapproval and informed consent form were obtained. Sociodemographic data form,Champion Health Belief Model for Breast Cancer, The Comprehensive Breast CancerKnowledge Test were used to compare the groups. Statistical analyses wereperformed using the IBM SPSS Statistics for Windows, Version 21.0RESULTS: Therewas no difference in the frequency of breast self-examination and clinicalbreast examination between the groups (p>0.05). There were statisticallysignificant differences in age, knowledge level, and education level betweenthe groups (p<0.05). There was a statistically significant differencebetween the education level of the health workers and community members(p=0.029). The median scores for each subscale of the Champion Health BeliefModel for Breast Cancer were not statistically different between the groups.Self-efficacy was found the only predictive factor on the breastself-examination practice (p=0.00, OR:1.188). The most predictive factor waseducation level on the breast cancer knowledge level (p=0.00, r=0.315). Only36.5% of the participants had a high knowledge level.CONCLUSION: Thebreast cancer knowledge level, the behavior of breastself-examination and clinical breast examination are not more different in health workers than the othermembers of the society.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030

    • Authors: Selcan GÜLTUNA ; Seçil KEPİL ÖZDEMİR, Cem ÖZİŞLER
      Abstract: Purpose: The prevalence of atopy has been investigated in different autoimmune diseases in various studies. But, the atopic status in primary Sjögren’s syndrome (pSS) patients has not been evaluated yet. We aimed to determine the relationship between pSS and atopy. Material and Method: Fifty consecutive adult patients with pSS and fifty age and sex-matched controls were prospectively recruited in this study pSS patients were evaluated with laboratory tests and disease activity score. All subjects underwent skin prick test to a standard panel of common aeroallergens.Results: Ten patients (10/50, 20%) in the pSS group and five patients (6/50, 12%) in the control group had positivity on skin prick tests with common inhalant allergens (p=0.267). No significant differences were found regarding the clinical characteristics between atopic and non-atopic pSS patients.Conclusions: Atopic status and allergen sensitization were evaluated in pSS patients. To our knowledge, this is the first study investigating the inhalen allergen spectrum in pSS patients. The prevalence of atopy is similar in patients with pSS to the controls. But atopy may be related to milder clinical manifestations of pSS.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030

    • Authors: Berkay KÜÇÜK ; Salih TUNCAL , Osman AYDIN , Yılmaz ÜNAL , Yusuf Murat BAĞ , Zeynep ADIYAMAN , Mehmet ŞENES , Pınar CELEPLİ , Sema HÜCÜMENOĞLU , Bülent KILIÇOĞLU , Kemal KISMET , Ertuğrul ERTAŞ
      Abstract: ABSTRACT: OBJECTIVE: It was aimed to demonstrate the efficacyof Calcium Dobesilate (Ca-Dob) in preventing postoperative intra-abdominaladhesion formation in an experimental cecal abrasion model. MATERIALS AND METHODS: Thirty femaleWistar Albino rats were randomized into 3 groups. In the sham group, the cecumwas removed from the abdomen and replaced without any further processing. Inthe control group, after cecal abrasion and peritoneal resection no processingwas applied. In the Ca-Dob group, after cecal abrasion and peritoneal resection,100 mg/kg/day Ca-Dob was administered. All rats were sacrificed on 21st day.The evaluation of adhesions was made through the degrees of bowel inflammationand fibrosis in tissue samples and the biochemical analysis of tissue and bloodsamples. RESULTS: Statistically, inflammation, microscopic adhesions and fibrosis scoreswere found to be significantly lower in the Ca-Dob administered rats compared to the control group (p< 0.05). Tissue MDA, FOP and TOS values were found to be significantly lowerstatistically compared to the control group (p = 0.001). Tissue total SH valueswere found to be statistically significantly higher (p < 0.05) in the shamgroup compared with the control group. Finally; serum MDA and serum TOS values inthe Ca-Dob group, was statistically significantly lower (p < 0.05) comparedto control group. CONCLUSION: Ca-Dob was found to be efficacious in preventing theformation of adhesions. In addition to the demonstrated anti-inflammatory effecthistopathologically, the effect of antioxidant effect demonstratedbiochemically was concluded to participate to the adhesion preventive efficacyof Ca-Dob.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030

    • Authors: Suleyman KARAKOSE ; Zeynep BAL , Burak SAYİN , Mehtap ERKMEN AKDOĞAN , Dilek GOKUSTUN , Emre TUTAL , Siren SEZER
      Abstract: PURPOSE: Vascular calcification (VC) is highly prevalent in maintenance hemodialysis (MHD) population and increasing evidence indicates that abnormalities in mineral metabolism are closely associated with VC and increased mortality in chronic kidney disease (CKD) patients. In our study, we hypothesized that high FGF-23 and low endogeneous vitamin D levels might be a result of high calcium load and aimed to determine the relationship between 25-hydroxy vitamin D levels and arterial stiffness in CKD patients. MATERIALS AND METHODS: One hundred and seventeen patients who were receiving MHD 3 times a week for at least 24 months were selected and followed up for 12 months.We analysed the influence of one years’ cumulative calcium and theraupetic vitamin D (paricalcitol and calcitriol) intake, and serum FGF-23 level on 25(OH)D3 levels and the impacts of these parameters on the change in annual PWV measurement results in MHD patients. RESULTS: Elementary calcium dose was significantly higher in vitamin D insufficiency group than compared to control group (p=0.014). Seum level of FGF-23 were positively correlated with duration of HD (p=0.001), mean PTH (p=0.001), mean P (p=0.009) and mean CaxP (p=0.006). Baseline PWV measurement were similar between two groups however patients in insufficiency group had higher 12th month PWV measurements compared to control group (p=0.034). CONCLUSION: Calcium could increase serum FGF23 levels by indeterminate mechanisms independently of serum phosphate level. Elevated FGF-23 levels was found to be insulting a decline in vitamin D levels which may cause VC and stiffening of the arteries and resulting higher PWV measurements.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030

    • Authors: Eray ÇINAR ; Kubilay İNAN , Ozgur Omer YİLDİZ
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
  • Surgical outcomes in elderly patients with obstructed colorectal cancer:
           Single center experience

    • Authors: Enis DİKİCİER ; Muhammed KAMBUROĞLU , Emre GÖNÜLLÜ , Yeşim AKDENİZ , Kayhan ÖZDEMİR , Barış MANTOĞLU , Havva KOÇER , Fehmi ÇELEBİ
      Abstract: Aim: Colorectal cancer is the most common cause of large bowel ob-struction in elderly. The aim of this study is to compare the clinical findings and perioperative outcomes of elder and younger colorectal cancer patients who were urgently operated for obstruction in our de-partment. Material and Method: The files of patients who underwent emergency surgery for acute mechanical bowel obstruction due to colorectal cancer between January 2015 and December 2019 at the Sakarya University School of Medicine, Department of General Surgery were retrospective-ly reviewed. Results: A total of 187 patients who had emergency operation due to colorectal cancer-related obstruction in a 5-year period were included. 55.6% (n = 104) were over the age of 65, 46.4% (n = 83) were under the age of 65. ASA scores, tumor localization, and mean total hospital stay, duration of intensive care were statistically different between the two groups (p
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
  • Diffuse Large B Cell Lymphoma Presented with Masive Thyroid Gland
           Enlargement and Resembling Thyroid Cancer

    • Authors: Nebiye YAPICI YAPICI; Fatih KARAAHMET , Murat KEKİLLİ
      Abstract: A lymphoma case with massive thyroid gland enlargement and misdiagnosed with thyroid cancer is presented
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
  • Recommendations for Family Medicine System in Turkey

    • Authors: İzzet FİDANCI ; Duygu YENGİL TACİ
      Abstract: As the main component of primary health care services, the Family Medicine system has been introduced in most developed and developing countries, and almost all preventive health care services are provided through this system. A quality family medicine system will also reduce the burden of other healthcare institutions, as it includes ease of access to the patient and secondary protection, and will also increase their quality and efficiency. On the contrary, both the burden of other health institutions will increase and disruptions in preventive health services will occur due to unplanned density in the family medicine system.
      PubDate: Thu, 31 Dec 2020 00:00:00 +030
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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