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Dermatology Practical & Conceptual
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Online) 2160-9381
Published by Mattioli 1885 srl Homepage  [9 journals]
  • Porokeratosis of Mibelli

    • Authors: Constanza Riquelme-Mc Loughlin; Sebastian Podlipnik
      PubDate: Mon, 26 Oct 2020 13:40:35 +000
       
  • Multiple Dermatofibromas on the Legs

    • Authors: Gabriel Salerni; Carlos Alonso
      PubDate: Mon, 26 Oct 2020 13:37:52 +000
       
  • Familial Cutaneomucosal Venous Malformations

    • Authors: Juan Francisco Mir-Bonafe; Marc Mir-Bonafé, Jaime Piquero-Casals, Eduardo Rozas-Muñoz
      PubDate: Mon, 26 Oct 2020 13:34:38 +000
       
  • Red Plaque on the Dorsal Hand With Necrosis: Think Before You Amputate

    • Authors: Marc Mir-Bonafé; Javier Aubán-Pariente, Sheila Requena-López, Celia Gómez-de-Castro, Yolanda Hidalgo-García
      PubDate: Mon, 26 Oct 2020 13:31:05 +000
       
  • Pseudonits or Hair Casts

    • Authors: Vania Lukoviek; Josep Malvehy, Susana Puig, Sebastian Podlipnik
      PubDate: Mon, 26 Oct 2020 13:29:19 +000
       
  • An Open-Label Prospective Study to Compare the Efficacy and Safety of
           Topical Fluticasone Versus Tacrolimus in the Proactive Treatment of Atopic
           Dermatitis

    • Authors: Vinodhini R. Mudaliyar; Asha Pathak, Alok Dixit, Sweta Kumar
      Abstract: Background: Atopic dermatitis (AD), a chronic recurrent inflammatory skin condition primarily affects children. Topical treatment, systemic treatment, and phototherapy are mainstay of treatment. Objectives: Topical corticosteroids (TCS) are the first line therapy for AD but are associated with various adverse effects. Topical calcineurin inhibitor (TCI) can be used as an alternative to TCS. The aim of the study is to compare efficacy of topical preparation of fluticasone and tacrolimus in lowering the severity of disease, to assess the quality of life (QoL), and to estimate if any association exists between them. Methods: 37 AD children, randomly received either of the two topical treatments, daily application for first 4 week of in acute phase and twice weekly for next 4 week as maintenance phase. The severity of disease was assessed using SCORing Atopic Dermatitis (SCORAD) and QoL was assessed by using Children’s Dermatology Life Quality Index (CDLQI). Results:  At the end of acute phase, there was reduction in SCORAD score by 69.29% in fluticasone and 64.20% in tacrolimus group (P<0.001). In maintenance phase, the score had risen in fluticasone group by a mean difference of 0.81 while in tacrolimus, it decreased by 0.99. Both fluticasone and tacrolimus groups improved children’s QoL (P<0.001). Positive correlation (r=0.4668) exists between the SCORAD and QoL. Skin burning was the most common ADR seen with tacrolimus. Conclusions: Fluticasone and tacrolimus are equally efficacious in the treatment of AD, with similar benefits on children’s QoL. Tacrolimus is better in reducing the extent of lesions than fluticasone
      PubDate: Mon, 26 Oct 2020 13:22:59 +000
       
  • Validation of a Novel Cutaneous Neoplasm Diagnostic Self-Efficacy
           Instrument (CNDSEI) for Evaluating User-Perceived Confidence With
           Dermoscopy

    • Authors: Kelly C. Nelson; Ashley E. Brown, Amanda Herrmann, Chloe Dorsey, Julie M. Simon, Janice M. Wilson, Stephanie A. Savory, Lauren E. Haydu
      Abstract: Background: Accurate medical image interpretation is an essential proficiency for multiple medical specialties, including dermatologists and primary care providers. A dermatoscope, a ×10-×20 magnifying lens paired with a light source, enables enhanced visualization of skin cancer structures beyond standard visual inspection. Skilled interpretation of dermoscopic images improves diagnostic accuracy for skin cancer. Objectives: Design and validation of Cutaneous Neoplasm Diagnostic Self-Efficacy Instrument (CNDSEI)—a new tool to assess dermatology residents’ confidence in dermoscopic diagnosis of skin tumors. Methods: In the 2018-2019 academic year, the authors administered the CNDSEI and the Long Dermoscopy Assessment (LDA), to measure dermoscopic image interpretation accuracy, to residents in 9 dermatology residency programs prior to dermoscopy educational intervention exposure. The authors conducted CNDSEI item analysis with inspection of response distribution histograms, assessed internal reliability using Cronbach’s coefficient alpha (α) and construct validity by comparing baseline CNDSEI and LDA results for corresponding lesions with one-way analysis of variance (ANOVA). Results: At baseline, residents respectively demonstrated significantly higher and lower CNDSEI scores for correctly and incorrectly diagnosed lesions on the LDA (P = 0.001). The internal consistency reliability of CNDSEI responses for the majority (13/15) of the lesion types was excellent (α ≥ 0.9) or good (0.8≥ α <0.9). Conclusions: The CNDSEI pilot established that the tool reliably measures user dermoscopic image interpretation confidence and that self-efficacy correlates with diagnostic accuracy. Precise alignment of medical image diagnostic performance and the self-efficacy instrument content offers opportunity for construct validation of novel medical image interpretation self-efficacy instruments.
      PubDate: Mon, 26 Oct 2020 13:19:20 +000
       
  • Atypical Presentation of Congenital Triangular Alopecia: A Case Series in
           Italy

    • Authors: Michela Starace; Miriam Anna Carpanese, Diego Abbenante, Francesca Bruni, Bianca Maria Piraccini, Aurora Alessandrini
      Abstract: Background: Congenital triangular alopecia (CTA) is a benign, asymptomatic, nonprogressive, localized and noncicatricial type of alopecia that is usually first noted during infancy or childhood. The pattern of hair loss is traditionally described as triangular, oval or lancet shaped with apex toward the vertex. Objectives: We present a case series of CTA located in unusual sites. Patients and Methods: We performed trichoscopy in 78 patients with CTA. From this group, we selected 10 individuals (4 males and 6 females) whose disease was not localized on the typical scalp area. Results: The alopecic area was located on the occipital region in 5 patients, the parietal region in 4 patients, at the vertex in 1. With trichoscopy, vellus hairs were detected in all patients, and evidence of empty follicles was noticed only in 3 patients. Conclusions: In contrast with the preconceived notion that all CTAs are frontotemporal, our case series points out that this disease could be localized in other scalp sites.
      PubDate: Mon, 26 Oct 2020 13:16:21 +000
       
  • Diminished Expression of Galectin-3 Around Blisters in Bullous Pemphigoid:
           An Immunohistochemistry Study

    • Authors: Maryam Aghighi; Bruce Smoller
      Abstract: Background: Bullous pemphigoid (BP) is a subepidermal blistering disorder caused by autoantibodies directed against hemidesmosomal proteins. Many patients with BP demonstrate circulating IgE autoantibodies. Although the role of IgE in the pathogenesis of BP is unknown, a correlation between IgE antibodies and eosinophilia has been observed. Soluble CD23 and galectin-3 are the main elements of the IgE group. The roles for CD23 in BP as a potential biomarker and IgE production regulator have been characterized, but no studies have evaluated any roles for galectin-3 in this disease. Objectives: In this study, we evaluated galectin-3 expression in BP as a first step in assessing its role in the pathogenesis of this autoimmune blistering process.  Patients and Methods: Sixty specimens diagnosed as BP were stained with antibodies to galectin-3. The percentages of nuclear and cytoplasmic galectin-3 expression and staining intensity were evaluated. Results: There was a significant difference in galectin-3 cytoplasmic and nuclear expression within keratinocytes immediately surrounding and above the blisters: (1) cytoplasmic (mean = 17.2% ± 2.4%) vs adjacent unaffected skin (mean = 66.7% ± 2.0%, P < 0.0001) and (2) nuclear (mean = 1.9% ± 0.4%) vs adjacent unaffected skin (mean = 13.2% ± 1.2%, P < 0.0001). Conclusions: Lower expression of galectin-3 around blisters in BP may suggest a role as an adhesion molecule. Loss of galectin-3 may add to the extension of blister formation by initiating cell-extracellular matrix disassembly and may be involved with the associated dermal inflammation and the eosinophil chemotaxis. Further studies will be necessary to elucidate the result of this observed loss on disease pathogenesis.
      PubDate: Mon, 26 Oct 2020 13:14:11 +000
       
  • From Skin to Kidneys: The Cutaneous Clues of Renal Disease in Children

    • Authors: Mario Diplomatico; Pierluigi Marzuillo, Angela La Manna, Andrea Apicella, Stefano Guarino, Vincenzo Piccolo
      Abstract: Background:  The skin is often seen as a world apart, but not rarely do cutaneous manifestations reveal signs of systemic disease. Objectives: The aim of this review is to include in one paper all the possible correlations between nephrological and dermatological manifestations of the same disease in pediatric patients while also keeping in mind that in apparent exclusively dermatological  diseases there can be nephrological manifestations as part of the same disorder and vice versa. Methods: We searched on PubMed for a possible link between skin and kidney matching the following terms and correlated MeSH terms: dermatology, skin, kidney, renal disease, nephrology, pediatrics, child, childhood, vasculitis, and cancer. We selected only articles reporting a link between nephrology and dermatology in pediatrics, and they are all included in this comprehensive review. Results: Kawasaki disease, Henoch-Schönlein purpura, systemic lupus erythematosus, Dent disease, subcutaneous fat necrosis, Langerhans cell histiocytosis, renal cell carcinoma, non-Hodgkin lymphoma, tuberous sclerosis complex and syndromes with increased risk for Wilms tumor, Fabry disease, nail-patella syndrome, neurofibromatosis type 1, Beckwith-Wiedemann syndrome, Adams-Oliver syndrome 1, Apert syndrome, Fanconi pancytopenia syndrome, Pallister-Hall syndrome, and Fanconi pancytopenia syndrome are all conditions in which there can be both nephrological and dermatological manifestations in children. Conclusions: We could not any find reports that focused attention on the link between nephrological and dermatological manifestations of the same disease in children. It is also important for clinicians to keep in mind that in what may appear to be an exclusively dermatological disease, there can be nephrological manifestations as part of the same disorder and vice versa.
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Risks of Skin, Hair, and Nail Supplements

    • Authors: Emily K. Burns; Ariadna Perez-Sanchez, Rajani Katta
      Abstract: Skin, hair, and nail supplements, sometimes referred to as “beauty supplements” or “ingestible skin care”, are a large and growing industry. These products may contain vitamins and minerals, sometimes in very high doses. They may also contain herbs, hormones, microbes, or animal derivatives such as fish oils and collagen powders. Dietary supplements are regulated as foods, not drugs, by the U.S. Food and Drug Administration. Therefore, manufacturers do not need to provide any proof of safety, efficacy, or quality prior to sale. This is of serious concern, as many adverse effects due to supplement components have been reported. The potential risks cover multiple categories. These include acute toxicities such as choking, as well as chronic toxicities, such as increased risk of diabetes. Teratogenicity and interaction with drugs and laboratory testing have been documented in research studies. Other risks include potentially increased risk of cancer with long-term use, allergic reactions, and others. It is vital that physicians educate their patients on these risks. As no post-marketing surveillance programs are required for supplements, our understanding of supplement risks is incomplete. Physicians should be wary of these risks and encourage further research and regulation.
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Home Dermoscopy During the COVID-19 Pandemic

    • Authors: Andreas Blum; Michelle Menzies
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Dermoscopic Evaluation of Infantile Hemangioma Treated With Topical
           Timolol

    • Authors: Rubina Jassi; Sarita Sanke, Ram Chander
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • A Case of Pigmented Bowen Disease on the Finger Mimicking Melanoma Showing
           a Chaos Pattern on Dermoscopy

    • Authors: Ryoji Kurita; Yaei Togawa, Keisuke Suehiro, Hiroyuki Matsue
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Polymorphic Vessels—Think About Seborrheic Keratosis

    • Authors: Teresa Deinlein; Elena Eber, Regina Fink-Puches, Rainer Hofmann-Wellenhof
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Playstation Thumb: Frictional Dermatitis Caused by Excessive Video Game
           Playing

    • Authors: Jaime Piquero-Casals; Daniel Morgado-Carrasco, Juan Francisco Mir-Bonafé, Eduardo Rozas-Muñoz
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • A Peculiar Case of Darier Disease in Blaschkoid Distribution

    • Authors: Francesca Peccerillo; Sabrina Longhitano, Barbara Ferrari, Laura Bigi, Giovanni Pellacani, Giulia Odorici
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Purpuric Plaques—Dermoscopic and Histopathological Correlation of
           Cutaneous Angiosarcoma

    • Authors: Daniel W. Cole; Tomas Huerta, Aleodor Andea, Trilokraj Tejasvi
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Dermoscopy of Syringotropic and Folliculotropic Mycosis Fungoides

    • Authors: Ružica Jurakić Tončić; Jaka Radoš, Danijela Ćurković, Ivana Ilić, Stefano Caccavale, Mirna Bradamante
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • A Case of a Pigmented Epithelioid Melanocytoma on a Mucosal Site

    • Authors: Alice Ramondetta; Simone Ribero, Luca Conti, Pietro Quaglino, Paolo Broganelli
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Dermoscopy of Lip Lichen Planus—A Descriptive Study

    • Authors: Sunmeet Sandhu; Shekhar Neema, A.W. Kashif, Preema Sinha, Rohit Kothari, S. Radhakrishnan
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Dermoscopy of Pigmented Purpuric Lichenoid Dermatitis of Gougerot and Blum
           in an HIV-infected Patient

    • Authors: Pedro Miguel Garrido; Pablo Espinosa-Lara, Marta Aguado-Lobo, Luís Soares-Almeida, João Borges-Costa
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Clinical and Dermoscopic Features of an Extradigital Glomus Tumor of the
           Back

    • Authors: Maha Lahouel; Ines Lahouel, Yosra Soua, Mouna Ben Hammouda, Manel Njima, Monia Youssef, Jameleddine Zili
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Bubble Hair and the Usefulness of Trichoscopy

    • Authors: Aurora Alessandrini; Michela Starace, Francesca Bruni, Bianca Maria Piraccini
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Secukinumab: Rapid Efficacy in Psoriasis After Primary Failure With
           Ustekinumab and Adalimumab

    • Authors: Aline Lissa Okita; Tatiane Benini, Denise Reis Longhi
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Carbon Peel Laser Technique to Improve Skin Quality: Back to Science!

    • Authors: Stefania Guida; Elisabetta Fulgione, Ilaria D'Ambra, Graziella Babino, Giovanni Pellacani, Francesca Farnetani
      PubDate: Mon, 26 Oct 2020 00:00:00 +000
       
  • Diagnostic Accuracy of Dermoscopy of Actinic Keratosis: A Systematic
           Review

    • Authors: Karla L. Valdés-Morales; María Luisa Peralta-Pedrero, Fermín Jurado-Santa Cruz, Martha Alejandra Morales-Sanchez
      Abstract: Introduction: Dermoscopy is a tool that aids clinicians in the diagnosis of actinic keratosis; however, few diagnostic accuracy studies have determined its sensitivity and specificity for this diagnosis. Objective: Determine the diagnostic accuracy of dermoscopy on actinic keratosis. Methods: A systematic review was conducted on EMBASE, PubMed, Scopus and the Cochrane Central Registry of Controlled Trials from inception to August 2019. Results: We screened 485 titles and abstracts. Two studies comprising 219 actinic keratoses were eligible for qualitative analysis. The number and heterogeneity of included studies limited a quantitative analysis. Conclusions: Studies that focus specifically on the diagnostic accuracy of dermoscopy for actinic keratosis are lacking.
      PubDate: Wed, 26 Aug 2020 00:00:00 +000
       
 
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