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Biomanufacturing Reviews
Number of Followers: 0  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 2363-507X - ISSN (Online) 2363-5088
Published by Springer-Verlag Homepage  [2574 journals]
  • Biopolymers for microneedle synthesis: from then to now
    • Abstract: Biopolymeric microneedles have emerged as an efficient tool for transdermal drug delivery system. Being operational alternative to hypodermic needles and non-biopolymeric microneedles, they offer plethora of advantages and ease in drug administration over conventional tools. Needles/microneedles used in medical practise can be disposable devices but may not necessarily be biodegradable, whereas biopolymeric microneedles completely serves for the green technology approach at medical/pharmaceutical outlet. Over a decade, investigation has been engrossed on leveraging biopolymers for microneedle synthesis, however, it seems to be growing more towards synthetic biopolymers than those of non-synthetic/natural biopolymers, may be due to their inherent physico-chemical properties. Nonetheless the outcomes bestowed from the investigations on natural biopolymeric microneedles are surely pertinent to the future practical applications. Henceforth, with the purpose of having insight, illuminating their potential and encouraging their utilisation for developing drug delivery devices, this review summarizes them from then to now with their implicational advancement and clinical potential.
      PubDate: 2019-09-30
       
  • Cultured meat: state of the art and future
    • Abstract: Cultured meat or in vitro meat offers a safe and disease-free way forward to meet increasing meat requirement without involving animal sacrifices and at the same time, reducing greenhouse emissions, as compared to conventional meat. However, its cost, scale-up, public neophobia and technophobia, and incomplete understanding of health benefits, limits its commercial viability. This review looks into technological advances and limitations in this area and at the same time, critically analyses the social concerns, making a case for in vitro meat. This paper also looks into the new startups which have ventured into the area but are facing issues due to social perception and lack of regulatory guidelines.
      PubDate: 2018-03-19
       
  • Role of medicinal plants in neurodegenerative diseases
    • Abstract: Neurodegenerative diseases, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are characterized by progressive loss (and even death) of structure and function of neurons, and have created great burden to the individual and the society. The actual cause of various neurodegenerative diseases still remains a mystery in healthcare. Some of the commonly studied environmental factors causes for neurodegenerative diseases are protein degradation, oxidative stress, inflammation, environmental factor, mitochondrial defects, familial history, and abnormal protein accumulation in neuron. However ageing plays a very important role in neurodegenerative diseases. Medicinal plants and natural compounds, such as Withania somnifera (ashwagandha), Ginseng, curcumin, resveratrol, Baccopa monnieri, Ginkgo biloba, and Wolfberry have been applied to prevent or alleviate neurological diseases and relief of neurological symptoms reported in in vivo or in clinical trails. Natural compounds in nanosize range as a therapeutic agent possess the same activity as in native state. Nanodrug delivery helps to increase the bioavailability of the drug and thereby specifically target cells and tissues. Nanoparticles, polymeric nanomicelles, complex polymers nanocrystal, and nanofibers are used to carry the medicinal plants for drug delivery system in the treatment of neurodegenerative diseases. Especially, electrospinning and electrospraying as straightforward yet versatile techniques for the production of nanosized fibers and particles possess huge potential in encapsulation of natural compounds for the neurodegenerative diseases. This review is a study to understand the role of nanotechnology and natural compounds in neurodegenerative diseases associated with ageing.
      PubDate: 2017-10-24
       
  • Advances in bioprinted cell-laden hydrogels for skin tissue engineering
    • Abstract: Bioprinting technologies are powerful additive biofabrication techniques to produce cellular constructs for skin tissue engineering owing to their unique ability to precisely pattern living and non-living materials in pre-defined spatial locations. This unique feature, combined with the computer controlled printing and medical imaging techniques, enable researchers and clinicians to generate patient specific constructs partly replicating the intricate compositional and architectural organization of the skin. Bioprinting has been used to automatically dispense hydrogels with skin cells located in prescribed sites that promote skin formation in vitro and in vivo. Current skin bioprinting approaches mostly rely on the sequential printing of fibroblasts and keratinocytes embedded within a homogeneous hydrogel. Although such approaches have already been translated to pre-clinical scenarios, they still present limitations in terms of fully replicating the cellular and extracellular matrix (ECM) heterogeneity in native skin. The success of bioprinting for skin repair strongly depends on the design of printable bioinks capable of supporting the function of printed cells and stimulating the production of new ECM components. To better mimic the human skin, novel developments in dedicated bioprinting technologies, in the design of bioinks, as well as in the printing of vascularised constructs are necessary. This paper presents an overview regarding the use of bioprinting for skin tissue engineering applications. The operating principles of bioprinting technologies are outlined along with requirements of printed skin constructs. Finally, pre-clinical results are summarized and future perspectives for the field are highlighted.
      PubDate: 2017-08-08
       
  • Computational mechano-chemo-biology: a tool for the design of tissue
           scaffolds
    • Abstract: Computational modeling is usually employed for simulation, design and manufacturing of tissue scaffolds, specially focused on macroscopic and microscopic properties, relying on anatomy and geometrical constraints. However, these models typically require to take into account the effects of cell-matrix interaction due to its crucial influence on a range of cellular processes including cell adhesion, differentiation and tissue formation among others. Computational mechano-chemo-biology is a numerical approach that aims to consider this interaction by means of a multiphysics and/or a multiscale computer framework. This article reviews some of the recent progress made in modeling bone regeneration induced by scaffolds, taking into account cell-matrix interactions. The issues covered in this work include different kind of numerical models at different length scales that go from cell-matrix interaction to tissue mechanics. The review concludes summarizing the main challenges that researchers face to consolidate modeling as a final design tool for tissue engineering.
      PubDate: 2016-11-05
       
  • Metals for bone implants: safety, design, and efficacy
    • Abstract: Like most bone deficits, mandibular segmental defects may result from surgical reconstruction due to congenital deformity, tumor resection, other pathologies, senescence, trauma, or infection. The goals of mandibular reconstruction are to restore the mandible’s function and normal appearance. Clinical methods to restore the mandible typically rely on bone replacement using some combination of bone tissue transfer and metal implants. This paper reviews the safety, design, and efficacy of metal implants in general and specifically for the repair of mandibular segmental defects. These problems include implant incorporation, implant failure mechanisms (e.g., stress concentration, stress shielding), corrosion and toxicity, infection, and muscle re-attachment. Finally, this paper presents the use of porous nickel-titanium (NiTi) implants for the repair of skeletal defects through the example of mandibular segmental defects. Resorbable magnesium, and porous and non-porous NiTi, immobilization hardware are also discussed. These materials provide new options which may better match the material properties, and if they can be 3D printed, better match the shape of surrounding host tissue. These advances might reduce engrafted bone and metal implant failure and restore musculoskeletal function for the long term. Patient-specific hardware and grafting strategies might prove to be useful tools in determining both the patient’s appearance and functional outcome following reconstructive musculoskeletal surgery.
      PubDate: 2016-10-06
       
 
 
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