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Journal of Ozone Therapy
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  This is an Open Access Journal Open Access journal
ISSN (Print) 2444-9865
Published by Universitat de Valencia Homepage  [34 journals]
  • Good prospects

    • Authors: Jose Baeza Noci
      Abstract: This third issue compiles the papers sent during 2017 and some others sent in 2018, so I apologise all the authors for the delay and thank them for their patience. The 4th issue will be devoted to be the proceeding of the World Congress organized by Dr Lamberto Re in Ancona - Italy in 2017 and will be published by Summer-19. Issue number 5 will be devoted to spine diseases thanks to the wonderful effort done by Dr. Alberto Alexandre from Treviso - Italy. The rest of the papers already sent and new to come will be published on 2020. The indexation of this journal is so fantastic, thanks to the University of Valencia’s Publication Service, that it is quickly compiled in all open journals search indexes. We will be included in other search engines as soon as we fulfil their requirements. By the moment, the only thing we need is papers. This issue has scientific articles devoted to basic investigation, toxicity and security topics, AIDS, cardiology, hepatitis, neurology, odontology and osteoarthritis. All of them are very interesting and try to clarify some basic and clinical aspects of ozone therapy. I want to express my most sincere gratitude to all the reviewers - members of the editorial board - that have collaborated and really helped to increase the quality of all of them. Peer review process is our corner stone in order to publish a good quality journal, as I believe this is. For the readers, I thank them for reading our journal so much and download our papers so many times; you can read in the STATISTIC section (still on testing) the great impact our journal is having in the scientific community. I also encourage them to publish their experience. I know that many of them have never published and are afraid of doing it, but I promise I will help anybody that wants to write a paper to do it. Some of you have already checked this. I wait for your papers meanwhile we prepare the next issues! Prof. Jose Baeza-Noci WFOT Past-President JO3T Editor-in-chief
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.15390
      Issue No: Vol. 2, No. 3 (2018)
  • Scientific approach for ozone absorption in blood during systemic indirect
           endovenous ozonetherapy

    • Authors: Jose Baeza-Noci, Rosa Pinto-Bonilla, Leonor Contreras-Velasco, Manuel Gomez-Moraleda
      Abstract: Introduction. Reading reference ozone books from Dra. Menendez, Dra. Viebhan, Dra. Borrelli and Dr. Bocci, proper timing for mixing ozone in blood during autohemotherapy is not calculated in a scientific way, having only an estimation of it based on changes in the blood color, more related to oxygen absorption than on ozone itself. Material and methods. We decided to reproduce a reduced model of great autohemotherapy or recently renamed as systemic indirect endovenous ozonotherapy (SIEVO) by the World Federation of Ozone Therapy – WFOT, using syringes to simplify the experiment. Our model consisted of a 20 mL syringe filled with 10 mL of blood withdrawn from healthy volunteers and mixed it gently but in controlled way with 10 mL medical ozone at different concentrations; after 5 and 8 seconds, the remaining gas was analyzed by an spectrophotometer based ozone detector to check the amount of ozone. Data were analyzed using a linear regression model. Results. Results show that even for 60 mcgr/mL ozone concentration, 8 seconds is enough to let all ozone absorbed in blood. Discussion and Conclusions. The experiment shows how quick ozone reacts with blood and claims for a trial with real SIEVO devices to achieve a real timing.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.9611
      Issue No: Vol. 2, No. 3 (2018)
  • Importance of the toxicological tests in the application and safety of
           ozone therapy

    • Authors: Silvia Menendez-Cepero, Zullyt Zamora, Frank Hernandez
      Abstract: Until today, there is not any official registry of the different routes of systemic ozone therapy. With the aim to prove the safety of this therapy, several ways of ozone (O3) applications were evaluated, such as rectal insufflation (RI), major autohemotherapy (M-AHT) and intraperitoneal application (IP). For RI, some toxicological tests were performed such as: acute, sub-chronic, mutagenic (bone marrow chromosomic aberrations and micronucleus), teratogenic  and irritation studies (at 40 mg/L and 10 mL during 15 days). For M-AHT, acute toxicological (in rats with 21, 47 and 64 mg/L and a volume of 2 mL with daily evaluation up to 15 days) and mutagenic (chromosomal aberration analysis, micronucleus assay and sister chromatid exchange test) studies were performed. For IP application, subchronic (O3 was administered during 15 days in mice at concentrations of 11, 29 and 35 mg/L and volumes of 80 mL/kg) and genotoxic (cytotoxic and clastogenic activity) studies were evaluated. All the toxicological studies performed for the O3 RI fulfilled the requirements established for an official registry (no deleterious effects were observed). However, more toxicological studies must be done with respect to M-AHT and IP O3 applications in order to prove the complete safety of these ways.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.10009
      Issue No: Vol. 2, No. 3 (2018)
  • Major autohemotherapy as a treatment modality for alveolar osteitis

    • Authors: Mosaad Abdaljawwad Khalifah
      Abstract: Purpose. Alveolar osteitis is the most common post-odontectomy complication. Although blood clot disintegration is known to be the cause of the condition, an agreement is lacking regarding a treatment of choice. The aim of the current study therefore was to evaluate major autohemotherapy as one treatment method. Patients and Methods. A total of 183 patients were categorized into 4 groups (I, II, III, and IV) according to pain severity (mild, moderate, severe, or agonizing, respectively). Major autohemotherapy was performed for all patients by withdrawing 225mL of patient's blood and mixing them with 225mL of Oxygen-Ozone gas (where Ozone concentration was 50µg/mL gas) Results and Discussion. Despite AHT was a high-potency curative treatment for groups I and II, it was palliative for group IV. For group III, it oscillated between being a curative or a palliative treatment with a statistically insignificant difference. Conclusion. AHT might be a recommended treatment for AO
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11292
      Issue No: Vol. 2, No. 3 (2018)
  • Clinical behavior of children with infantile cerebral palsy after ozone

    • Authors: Benjamin Arenas, Jose Luis Calunga, Silvia Menendez-Cepero, Carmen Vera, Mariela Infante, Manuel Herrera, Olga Franco, Alicia Angela Gorzelewski
      Abstract: Objective. The aim of this study was to determine the usefulness of ozone therapy in the treatment of Infantile Cerebral Palsy (ICP). Patients and methods. A non-controlled clinical assay was made in the Ozone Research Center (CIO), Havana, Cuba from January 2013 to January 2014. The sample was constituted by patients remitted to pediatrics consultation of CIO, to whom inclusion and exclusion criteria were applied. The study group involved 45 patients, from 1 month of birth to 8 years, with cerebral palsy of hypoxic-ischemic cause. The evaluation criteria were: evolution of the motor disorder according to the Gross Motor Function Classification System (GMFCS) scale, modification of muscle tone (Ashworth modified scale) and response to treatment (O’Brien modified scale). The way of administration was rectal insufflation; concentrations between 15, 20, 25 and 30 mg/L were used, volumes varied according to age, making calculation of the dose of ozone according to kilograms of weight. Cycles of 20 sessions, every 3 months were indicated, until completing 4 in 16 months. Patients were clinically evaluated, according to the scales used, before and after each cycle. Results and Discussion. The best answer to treatment was obtained in the group aged ' 4 years. The variables analyzed showed a significant improvement when the ozone treatment concluded. With respect to the evolution of the motor disorder, in 65 % of cases it improved. In the group of children below 4 years, the response was better in relation to the muscle tone. Response to treatment, according to the relatives’ criteria, was of 70 % of the children with marked improvement in the tone and muscle function. Conclusions. The greatest percentage of patients improved in the evolution of the motor disorder; when the Manual Ability Classification System (MACS) scale was applied, more than half the patients showed an improvement. A high percentage of children get a satisfactory result regarding muscle tone and motor function. No side effects were present in any of the cases during the study.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11205
      Issue No: Vol. 2, No. 3 (2018)
  • Ozone therapy in idiopathic carpal tunnel syndrome. Biochemical,
           neurophysiological and clinical aspects

    • Authors: Marco Willelmo Rascaroli, Barbara Borghi, Alessandro Rascaroli, Valter Travagli
      Abstract: Purpose. Idiopathic Carpal Tunnel Syndrome (CTS) is the most common entrapment neuropathy; however few and only retrospective studies have been found in search engines about Ozone Therapy. The aim of this paper was to evaluate clinical and neurophysiological outcome following Ozone Therapy in CTS. We focused the attention on the evidences concerning the role of Subsynovial Connective Tissue (SSCT) in the pathogenesis of CTS and the ozone pre-conditioning effects linked to pain and inflammatory pathways and to fibrosis induced by Ischemia-Reperfusion Injury. Materials and methods. Thirty-five patients, aged between 21 and 80, were stratified clinically by Boston Carpal Tunnel Questionnaire (B.C.T.Q.) and Neurophysiologically by Padua’s Gravity Scale classifying patients into five Electro-myographic categories. The mean symptom duration was also recorded. The patients filled in the B.C.T.Q. before and after treatment as well underwent diagnostic neurophysiological tests, strictly standardized in stimulation parameters, electrodes placement and skin temperature. The Ozone Therapy was performed by injecting 4 ml of O2-O3 mixture at 10 ug/ml concentration under the transverse carpal ligament twice a week for eight sessions. Results. We compared the B.C.T.Q. scores and the neurophysiological parameters obtained before and after O2-O3 treatment: the improvement of symptoms was significantly greater than the improvement of motor and sensory nerve conduction. The highest clinical improvement degree was found in patients classified in Mild and Moderate Groups. Discussion and Conclusion. Ischemia-Reperfusion Injury triggers oxidative stress in SSCT with activation of chemical mediators and neo-angiogenesis leading to non-inflammatory fibrosis that represent the allmark of CTS. Previous and retrospective studies based O2-O3 treatment on the main mechanisms of action shared by the treatment of herniated disc in the spine; our study focused the attention on pathophysiology of the SSCT trying to recognize the various stages of CTS pathogenesis by correlating with clinical and neuro-physiological tests. Further studies have to be carried out to better understand these relationships and optimize timing of Ozone Therapy.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11286
      Issue No: Vol. 2, No. 3 (2018)
  • Response of patients with chronic hepatitis B in one year of treatment
           with major autohemotherapy

    • Authors: Javier Cespedes-Suarez, Yanisley Martin-Serrano, Maria Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa
      Abstract: The Hepatitis B (HVB) is one of the most common infectious diseases in the world, it’s wide geographical distribution is a health problem, especially on the African continent, with prevalence rate of 6.1% in the adult population. Current treatment requires prolonged therapy (most cases for the rest of life) with the aim of stopping viral replication, maintaining immunological stability, preventing progression of liver disease and the most feared complications such as cirrhosis and hepatic cancer There are multiple references that point to ozone therapy as an alternative in the treatment of Hepatitis B, because of the known and demonstrated antimicrobial and immunomodulatory properties. With these premises, we performed the present clinical study that included 28 patients with positive diagnosis of chronic Hepatitis B, surface antigen (HVBs Ag) positive, antibodies against surface antigen (HVBs) negative, viral load (HVB DNA ) and transaminaseselevated. These patients with 1 year of evolution and antiviral treatment were treated with Major Autohemotherapy with protocol of 15 sessions and maintenance every 15 days to 50 mcg of concentration, initial dose of 4,000 mcg / ml up to 12,000 mcg /ml We indicate Ag HVBs, Ac HVBs, HVB Viral Loading and transaminases before starting treatment at 15 days of completion and quarterly until the year. The results showed negativization of the surface antigen, antibody positivity against the surface antigen, significant decrease of viral load to undetectable values and normal values of the transaminases demonstrating the functional recovery of the disease associated with favorable immunological response providing a better quality of patients' lives. Key words: Hepatitis B, Transaminases, Ozone therapy, Major Autohemotherapy, Surface antigen, Surface Antigen Antibody.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11459
      Issue No: Vol. 2, No. 3 (2018)
  • Clinical study of patients with heart failure under treatment with ozone

    • Authors: Javier Cespedes-Suarez, Yanisley Martin-Serrano, Maria Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa
      Abstract: Heart failure (HF) is framed in one of the types of cardiovascular diseases; it consists of an acute and chronic form. The disease can evolve slowly from asymptomatic left ventricular dysfunction, to a state of severe disability, presenting a wide prevalence in the population around 10% in people over 70 years old. More than three-quarters of the deaths from this pathology normally occur in low or middle-income countries. Angola is not exempt from this health problem be observed in a relatively young people, bringing disability and death at an early stage of life. Scientific advances and innovative treatments for the control and prevention of the disease continue to be insufficient. The ozone for it’s antioxidant, hemorheologic properties, oxygenation enhancers and blood circulation is an alternative treatment for these patients. We have performed a study where 45 patients who were diagnosed with a chronic stage of II-III HF due to the functional classification of the New York Heart Association (NYHA) and American Cardiology College / American Heart Association (ACC / AHA), previous echocardiogram with a Fracture of Left Ventricular Ejection (LVEF) less than 45%. We administered a Major Autohemotherapy with a protocol of 15 sessions, maintenance every 15 days and cycles every 6 months at 50'g of concentration, an initial dose of 4,000 'g / ml up to 12,000'g / ml during the 3 years of treatment. Patients after the first treatment cycle improve their functional physical capacity and LVEF increased to normal levels (55%). It was proved that Autohemotherapy is an adjuvant, viable and beneficial treatment in chronic HF. Key words: Heart failure (HF), Major Autohemotherapy, Ozone therapy, Fracture of Left Ventricular Ejection
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11461
      Issue No: Vol. 2, No. 3 (2018)
  • The immune response behavior in HIV-AIDS patients treated with ozone
           therapy for two years

    • Authors: Javier Cespedes-Suarez, Yanisley Martin-Serrano, Maria Rosa Carballosa-Peña, Diana Rosa Dager-Carballosa
      Abstract: HIV continues to be one of the biggest problems for the global public health. The African region is one of the most affected, accounting for almost two thirds of the new infections. Many of them are retroviral medications and multi-therapies aiming to stop the viral replication and maintaining immunological stability, which fail to guarantee the quality of life or enhance the patient's immunity Ozone has biological properties, among which the antimicrobial and modulatory effect on the immune response is highlighted, which makes it possible to use it in a complementary way for the treatment of these patients. We conducted the present study in which the effect of the ozone therapy administered systemically (blood route) is analyzed. We have studied 32 patients to whom we applied Major Autohemotherapy with a protocol of 15 sessions and maintenance every 15 days at 50 µg/ml of concentration; the initial dose was 4,000 µg/mlup to 12,000 µg/ml We indicated viral load, CD4 and CD8 counts before and at the end of therapy. The results showed a significant decrease in viral load to undetectable values and an increase of CD4 and CD8 at the end of the 15 sessions, being maintained at 2 years of treatment, thus achieving a permanent activation of the immune system and improving the quality of life of these patients. Key words: Ozone therapy, HIV-AIDS, Immune Response, Major Autohemotherapy
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.11458
      Issue No: Vol. 2, No. 3 (2018)
  • The efficacy of intra-articular PRP, ozone and ozone+PRP injections in
           patients with osteoarthritis

    • Authors: Lale Yeprem, Aysegul Ellialtioglu, Jose Baeza-Noci
      Abstract: Osteoarthritis (OA) is the most common form of arthritis and some joints are effected more than others. The prevalence of OA increases with age and it represents the major problem for functional impairment in older patients. Non-surgical treatment with oral drugs is not suitable for many patients suffering from gastric disorders, high blood pressure or different heart diseases. Intra-articular injections are a promising solution in these cases. This study was performed to compare the efficacy and safety of ozone injections, PRP (platelet rich plasma) injections and combined ozone plus PRP injections in patients with symptomatic knee OA. 120 patients were diagnosed of OA according to the criteria of the American College of Rheumatology and included into this study. Patients were randomly divided into three equal groups (40 patients each group). We include patients whose VAS score was 5 or above. Patients with inflammatory, endocrine and metabolic disturbances, and patients who had meniscectomy within the past 10 years, extra articular surgery within the last year, arthrocentesis in last 6 months or any drug given intra-articular were not included. We did not include either patients with misalignment. Patients in the first group were treated with intra-articular injections of ozone/oxygen gas mixture 2 times/week, at 10 µg/mL concentration and a volume of 5 mL for a total of 12 injections. Patients in the second group were treated only with PRP injections once a week for a total of 3 times. Patients in the third group were treated with intra-articular injections of Ozone+PRP (10 µg/ml concentration, 5 ml volume) once a week for a total of 3 times. The pain levels of patients were measured with Visual Analog Scale (VAS). Side effects were collected using an open list record. All the groups improved their baseline VAS in a significant way, although the group with the best results was group 3 with the combination of ozone and PRP in the same injection. We are planning further studies including systemic ozone in order to improve more the pain in our patients.
      PubDate: 2018-12-15
      DOI: 10.7203/jo3t.2.3.2018.10904
      Issue No: Vol. 2, No. 3 (2018)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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