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Medicine and Pharmacy Reports
Number of Followers: 1  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2602-0807 - ISSN (Online) 2668-0572
Published by Iuliu Hațieganu University of Medicine and Pharmacy Homepage  [1 journal]
  • Hepatocellular carcinoma in patients with autoimmune hepatitis – a
           systematic review of the literature published between 1989-2016

    • Authors: Simona Valean, Monica Acalovschi, Dan L. Dumitrascu, Lidia Ciobanu, Georgiana Nagy, Romeo Chira
      Pages: 99 - 105
      Abstract: Background and aims. Liver cancer is one of the most common cause of deaths from cancer. Hepatocellular carcinoma (HCC) was reported at a frequency of 7% of patients with autoimmune hepatitis (AIH) - related cirrhosis in 1988. We aimed to provide a systematic literature review on the frequency of HCC in patients with AIH, after the discovery of hepatitis C virus (HCV), in order to avoid any possible confounding etiology. Methods. A literature search of the PubMed database between 1989-2016 was performed, using the relevant keywords “hepatocellular carcinoma” and “autoimmune hepatitis”. We followed the PRISMA statement guidelines during the preparation of this review. Results. Eleven studies (n=8,460 patients with AIH) were retained for the final analysis. HCC was diagnosed in 0-12.3% of the AIH patients included in these studies. The overall occurrence of HCC in patients with AIH was estimated in two studies, at 5.1% and 6.2%, respectively. In patients with AIH and cirrhosis, the percentage of HCC varied between 0.2%-12.3%. The proportion of HCC in patients with AIH without cirrhosis was estimated at 1.03%. The percentage of cirrhosis in AIH patients varied from 18.7% to 83.3% in Japan, and from 12% to 50.2% in the other areas. The mean follow-up of the patients with AIH was of 10 years. Conclusions. The development of HCC in patients with AIH appeared to be similar before and after the discovery of HCV, and it was mainly associated to cirrhosis. The number of patients developing cirrhosis in relation with AIH was impressive. The long evolution of AIH to cirrhosis and, eventually, to HCC, has been be suggested.
      PubDate: 2019-04-19
      DOI: 10.15386/mpr-1228
      Issue No: Vol. 92, No. 2 (2019)
  • An overview of the common methods used to measure treatment adherence

    • Authors: Laura Alexandra Anghel, Andreea Maria Farcas, Radu Nicolae Oprean
      Pages: 117 - 122
      Abstract: Background and aims. The success of a treatment depends on the effectiveness of the medication regimen, provided that patients take the medicines as prescribed. A low rate of adherence in chronic conditions is associated with poor outcome and decreased quality of life, which constitutes an additional burden for the healthcare systems. To correctly identify the dimension of this problem may be a challenge, as there are numerous methods, definitions, patient settings and factors, each with their specific roles. Our aim was to give an appropriate overview of the most common validated methods that can be used to identify non-adherent patients. Methods. This overview is based on an online search of PubMed database and includes the relevant articles in this field. Results. We included both direct and indirect methods for measuring treatment adherence and presented concise information that can help researchers and clinicians when choosing an appropriate method. Both subjective and objective methods have advantages and disadvantages that should be fully understood and taken into consideration. Conclusions. Choosing a simple, accurate and inexpensive method that can give supplementary information about the patterns, beliefs and barriers of adherence would be desirable. But because this perfect method to measure treatment adherence does not exist, the best solution seems to be the combined use of at least two methods.
      PubDate: 2019-04-22
      DOI: 10.15386/mpr-1201
      Issue No: Vol. 92, No. 2 (2019)
  • Giomers in dentistry – at the boundary between dental composites and

    • Authors: Mara Elena Rusnac, Cristina Gasparik, Alexandra Iulia Irimie, Alexandru Graţian Grecu, Anca Ştefania Mesaroş, Diana Dudea
      Pages: 123 - 128
      Abstract: Introduction. From the variety of direct restorative dental materials, composite resins are considered as having the most esthetic and functional properties. The conservative preparation, esthetic results, good mechanical qualities and surface finishing properties of dental composites, combined with the protective properties of fluoride from glass-ionomers, led to a new generation of dental materials: the giomers. Objective. The purpose is to review the available literature about the giomers, regarding the chemical composition, handling properties and esthetics, adhesion and microleakage, fluoride releasing and protection offered, clinical indications. Method. The search was carried out using ScienceDirect and PubMed databases with the following keywords: giomer, esthetic properties giomers and fluoride releasing giomers. A total of 232 articles were initially selected, with the following inclusion criteria: full text articles, written in English, with topics on the properties and the clinical implications of giomers. Papers presented as abstract were not included.  In the next step, review articles, duplicates, and articles in other languages were removed; as a result, a total of 44 sources published between 2004 and 2017 were selected. Results. The selected articles referred to the following aspects about the giomers: chemical composition (8 articles), adhesion and microleakage (10 articles), fluoride releasing and pulp protection (15 articles), clinical indications (6 articles), effects of additional treatments and dietary habits (11 articles).
      PubDate: 2019-04-16
      DOI: 10.15386/mpr-1169
      Issue No: Vol. 92, No. 2 (2019)
  • Influence of concomitant medication on plasma concentration of amiodarone
           in patients with atrial fibrillation - A pilot study

    • Authors: Maria Adriana Neag, Dana Maria Muntean, Alexandra Nacu, Adrian Catinean, Anca Farcas, Stefan Vesa, Corina Bocsan, Laurian Vlase, Anca Dana Buzoianu
      Pages: 129 - 133
      Abstract: Background. Although amiodarone is a drug with many side effects, it is one of the most commonly used drugs in the treatment and prophylaxis of supraventricular and ventricular arrhythmias. Aim. The purpose of this pilot study was to evaluate plasma concentrations of amiodarone in patients with atrial fibrillation (AF) and to identify possible drug-drug interactions between amiodarone and concomitant medications. Method. A prospective observational study was conducted in 27 consecutive patients treated with amiodarone from May to July 2017 in a Clinical University Hospital. The patients included met our inclusion criteria. HPLC-UV was the device used to determine the plasma concentration of amiodarone. Results. Only 51.8% of the patients had amiodarone plasma concentration within therapeutic interval (500-2500 ng/ml). The drugs associated to amiodarone in the therapeutic plan were diuretics, beta blockers, statins, antiplatelets, fluoroquinolones, non-steroidal anti-inflammatory drugs. We observed a statistically significant difference between the plasmatic concentrations of amiodarone in patients treated with furosemide vs. patients concomitantly treated with other drugs. Interactions between other mentioned drugs and amiodarone were not registered. We can report an underuse of amiodarone for more than 50% of the patients. Also, we found a significant interaction between furosemide and amiodarone, most likely through the interaction with MDR. Conclusion. Furosemide may influence the pharmacokinetics of P-gp-interfering drugs. However, the relevance of these findings needs to be confirmed and further research is needed to characterize the interaction between amiodarone and furosemide.
      PubDate: 2019-04-16
      DOI: 10.15386/mpr-1130
      Issue No: Vol. 92, No. 2 (2019)
  • Glycated albumin is correlated with glycated hemoglobin in type 2 diabetes

    • Authors: Dana Mihaela Ciobanu, Florina Bogdan, Cristina-Ioana Pătruț, Gabriela Roman
      Pages: 134 - 138
      Abstract: Background and aims. Glycated hemoglobin (HbA1c) retrospectively evaluates mean glycemia in the preceding 2-3 months and is the gold standard for assessing glycemic control, while glycated albumin (GA) is currently considered a short to intermediate term integrated glycemic control marker, since it reflects glycemic status over the last 3 weeks. We aimed to investigate the levels of GA, HbA1c and fasting glycemia in a group of patients with type 2 diabetes. Methods. The observational study included adult type 2 diabetes patients (n=135) according to inclusion and exclusion criteria, randomly selected from Clinical Centre of Diabetes, Cluj-Napoca, Romania. Fasting glycemia, GA, HbA1c and creatinine were measured using commercially available methods.  Results. Of the whole group, 62 (45.9 %) were men. Mean age was 62.1±8.6 years old, body mass index was 31.8±6.1 kg/m2 and diabetes duration was 10.0 (4.0; 15.0) years. Fasting glycemia was 162±13.7 mg/dl, GA was 28.0 (21.0; 40.0)% and HbA1c 8.9±2.3%. We found GA was significantly correlated with HbA1c (r=0.19; p=0.029) and fasting glycemia (r=0.32; p<0.001), while HbA1c was significantly correlated with fasting glycemia (r=0.40; p<0.001). Conclusions. GA was significantly correlated with both HbA1c and fasting glycemia in our patients with type 2 diabetes. While HbA1c is recognized as being the reference test for diabetes control monitoring, GA might a useful biomarker for assessing short to intermediate term glycemic control, particularly important in situations when HbA1c test cannot be reliable or earlier clinical decision making is mandatory.
      PubDate: 2019-04-23
      DOI: 10.15386/mpr-1247
      Issue No: Vol. 92, No. 2 (2019)
  • Evaluation of thyroid dysfunction in patients with nephrotic syndrome

    • Authors: Deepak Jain, Hari Krishan Aggarwal, Pavan Kumar Y M, Promil Jain
      Pages: 139 - 144
      Abstract: Background. Thyroid and kidney are interdependent on each other in many ways for optimal functioning of either organs. Proteinuria causes urinary loss of thyroid hormones and thyroid binding globulins in substantial amount resulting in subclinical/overt hypothyroidism. Autoimmunity, which can attack both the organs simultaneously, may also contribute considerably to the abnormal functioning of both organs. Aims and objectives. To study the effect of proteinuria on the thyroid function and its association with autoimmunity. Methods. The study was carried out on a total number of 60 patients with nephrotic range proteinuria attending the kidney and dialysis clinic PGIMS, Rohtak, India. Thyroid profile and baseline investigations along with Anti-TPO antibodies and renal biopsy were carried out on each patient. Patients were allocated to 2 groups based on Anti TPO antibody results: group A comprising 25 Anti-TPO Ab positive patients and group B comprising 35 Anti-TPO Ab negative patients. Results. Group A patients with Anti TPO antibody positivity had more elevated TSH levels (p<0.0001), proteinuria (p=0.0011) and serum creatinine (p=0.0137) as compared to group B patients. Group A patients had more diminished eGFR (p=0.0127) and serum albumin (p=0.0056) than patients in group B. TSH levels were positively correlated with proteinuria r=0.55 (p<0.0001, 95% CI 0.35 to 0.70) and serum creatinine levels r=0.56 (p<0.0001, 95% CI 0.36 to 0.71). TSH levels were negatively correlated with serum albumin levels r=-0.52 (p<0.0001, CI -0.68 to -0.31) and glomerular filtration rate r=-0.54 (p<0.0001, CI -0.69 to -0.33). On histopathology, membranous nephropathy   - 29 out of 60 patients, 48% - was the most common finding in both the groups. Conclusions. Nephrotic range proteinuria leading to thyroid dysfunction is a common entity but the association with autoimmunity causes an exaggerated effect on both these organs. Our study established a significant correlation between thyroid autoimmunity and nephrotic syndrome. Thus, a high index of suspicion should be kept in all patients with nephrotic syndrome to look for any associated antibodies against thyroid antigens. Autoimmunity causes more proteinuria and more elevations of thyrotropin leading to clinical hypothyroidism; however, the occurrence of overt hypothyroidism necessitating treatment needs further study.
      PubDate: 2019-04-23
      DOI: 10.15386/mpr-1091
      Issue No: Vol. 92, No. 2 (2019)
  • Knowledge, attitude and practice regarding hypertension among residents in
           a housing area in Selangor, Malaysia

    • Authors: Nurul Fatin Binti Buang, Nor Azlina A Rahman, Mainul Haque
      Pages: 145 - 152
      Abstract: Background and aims. Hypertension is becoming a global epidemic and threat to the world population. This cross-sectional study was carried out at a housing area in Selangor, Malaysia to study the knowledge, attitude and practice (KAP) regarding hypertension among the residents. Methods. A total of 110 respondents aged 18 years old and above were selected by convenience sampling. Data was collected using a structured interviewer-guided questionnaire with Likert-scale choices of answers. Results. All respondents were Malay with the mean age of 41 years [Standard Deviation (SD)=11.828]. The total mean and SD of knowledge, attitude and practice scores were 74.33 (SD=6.25), 44.22 (SD=5.05) and 27.55 (SD=2.86), respectively. There were significant positive correlations between knowledge with attitude (r=+0.393; p<0.001) and practice (r=+0.378; p<0.001). However, there was no significant correlation between attitude and practice (r=+0.120; p=0.212). There were significant fair positive correlations between age with knowledge (r=+0.402; p<0.001), attitude (r=+0.265; p=0.005) and practice (r=+0.337; p<0.001) regarding hypertension. Meanwhile, gender, educational level, employment status and family history had no significant association with knowledge, attitude and practice regarding hypertension. Conclusion. This study revealed that KAP regarding hypertension were associated with age, but not with other socio-demographic characteristics studied. The awareness, prevention and control programs of hypertension in their community should be increased, so that the residents could enjoy and maintain the healthy lifestyle.
      PubDate: 2019-04-23
      DOI: 10.15386/mpr-1227
      Issue No: Vol. 92, No. 2 (2019)
  • Evaluation of the efficacy of Phyllanthus niruri standardized extract
           combined with magnesium and vitamin B6 for the treatment of patients with
           uncomplicated nephrolithiasis

    • Authors: Alexandru Cealan, Radu-Tudor Coman, Vasile Simon, Iulia Andras, Teodora Telecan, Ioan Coman, Nicolae Crisan
      Pages: 153 - 157
      Abstract: Introduction. The aim of our study was to assess the efficacy of Phyllanthus niruri standardized extract, combined with magnesium and B6 vitamin, used to treat uncomplicated nephrolithiasis. Patients and methods. We included in the present study 48 patients with uncomplicated nephrolithiasis, with the maximum calculi diameter of up to 15 mm, confirmed by non-contrast-enhanced computer tomography. Each patient followed a three-month therapeutic regimen with the above mentioned combination, with imaging assessment of the calculi after treatment. Results. Per patient: The mean age of the patients was 48 years. The median number of calculi was 1 and the mean dimension was 5.5 mm. The stone-free status after treatment was not correlated with gender (p=0.7), side location (p=0.8) or with the number of calculi (p=0.3), but we found a correlation with the location in the upper or middle calyx (54.5% vs 13.8%, p=0.008) and with the maximum diameter (p=0.001). Per stone: 60 calculi were analyzed, 8.3% being located in the upper calyx, 36.7% in the middle and 55% in the lower one. After treatment, 40% were absent, 21.7% showed lower dimensions and 38.3% remained unchanged, with the mean reduction of 1.7 mm. We identified a cut-off value of ≤ 3 mm (AUC 0.9, CI:0.8-0.9, p<0.0001) for the prediction of stone-free status after treatment. Conclusions. The current treatment had the highest efficacy in achieving stone-free status for patients with calculi ≤ 3 mm, located in the middle or upper calyx. A higher duration of the treatment might show improved results.
      PubDate: 2019-04-23
      DOI: 10.15386/mpr-1246
      Issue No: Vol. 92, No. 2 (2019)
  • Pharmacokinetic interactions study between carvedilol and some
           antidepressants in rat liver microsoms – a comparative study

    • Authors: Maria Bianca Abrudan, Daniela Saveta Popa, Dana Maria Muntean, Ana Maria Gheldiu, Laurian Vlase
      Pages: 158 - 164
      Abstract: Background and aims. Cardiovascular diseases and depressive disorders are some of the most frequent diseases. The probability of concomitant prescription of antihypertensive and antidepressive medication is increasing. The aim of this study was to investigate the enzyme inhibition by bupropion, sertraline and fluvoxamine on the metabolism of carvedilol using rat pooled liver microsomes and to assess the importance of these interactions from the pharmacokinetic mechanism point of view. Methods. Two substrate concentrations (0.5 and 1 μM) and four inhibitor concentrations (0, 0.1, 0.75 and 1.5 μM) were used for each tested inhibitor. Results. The results of the in vitro experiments showed a significant decrease of the metabolic rate of carvedilol to 4'-hydroxyphenyl carvedilol, for all tested inhibitors, when the inhibitor was added to the incubation mixture containing the substrate. Moreover, an increase of the area under the concentration-time curve for carvedilol was observed after incubation with each  tested inhibitor compared with the control state (no inhibitor). The most potent inhibitor was sertraline, followed by fluvoxamine and bupropion. Conclusion. The co-administration of tested antidepressants led to a significant alteration of carvedilol’s metabolism in vitro. CYP2D6 inhibition is the main pharmacokinetic mechanism that can explain these drug-drug interactions, with possible clinical implications.
      PubDate: 2019-04-23
      DOI: 10.15386/mpr-1225
      Issue No: Vol. 92, No. 2 (2019)
  • Caries risk assessment using Cariogram model among smokeless tobacco users
           in India

    • Authors: Nandini Sen, Pratiksha Bathija, Tulip Chakravarty, Diptajit Das, Nidhi Singh Baghel, Tauseef Ahmad Khan
      Pages: 165 - 171
      Abstract: Background. Smokeless tobacco forms are known to have fermentable sugar compounds which may strengthen the development of cariogenic microbes. In addition, cervical abrasion of teeth occur at the site of tobacco pouch placement. These components may assume an essential role in caries advancement in smokeless tobacco users. Objective. The objective of the study was to assess caries risk among smokeless tobacco users using Cariogram model. Methods. A descriptive cross sectional study was conducted among 50 smokeless tobacco users of Udaipur for 3 months. Caries risk assessment was done by employing a proforma survey based on the Cariogram Model. Statistical analysis included descriptive statistics, Chi-square test and Stepwise multiple linear regression with 95% confidence interval and 5% significance level. Results. The majority of the smokeless tobacco users (46%) were found to be in the “Moderate” Streptococcus mutans count category and portrayed “Moderate” plaque amount score (82%). Smokeless tobacco users (34%) depicted a higher caries risk profile than the control group (6%) utilizing the Cariogram model. Conclusion. Cariogram model could be a useful tool to represent caries risk among smokeless tobacco users.
      PubDate: 2019-04-24
      DOI: 10.15386/mpr-978
      Issue No: Vol. 92, No. 2 (2019)
  • A comparative evaluation of fracture load of monolithic and bilayered
           zirconia crowns with and without a cervical collar: an in vitro study

    • Authors: Mainak Kanti Shah, Surbhi Bansal, Vandana Pathak, Shivani Bharadwaj, Astha Chauhan, Amit Singh Nirwan
      Pages: 172 - 177
      Abstract: Introduction. The use of zirconia based all-ceramic restorations are preferred nowadays owing to superior biologic and esthetic properties. However, these restorations have also reported higher incidences of fracture and chipping. The clinical success may be enhanced by optimizing the core design, through the introduction of monolithic zirconia, or the layered crowns can be strengthened by adding the cervical collar to them. Objective. This study was performed with the objective to compare and evaluate the fracture load of monolithic and bilayered zirconia crowns with and without a cervical collar. Methods. A prospective observational study was carried out to compare 45 fabricated zirconia crowns of three different designs on a customized metal mould. The samples were oriented on the metal mould and subjected to confocal microscope for the evaluation of marginal integrity followed by cementing the crown on the metal mould and subjecting it to the universal testing machine for the analysis for the flexural strength. Data were analyzed using one way Anova and t- test for inter and intra groups. The significance level was set at P ≤ 0.05. Results. The monolith zirconia crowns and layered zirconia crowns with cervical collar reported more flexural strength . Conclusion. The amount of force required to fracture the zirconia crowns was higher in the case of monolith zirconia crown and layered zirconia crown with cervical collar as compared to the layered zirconia crown without cervical collar.
      PubDate: 2019-04-24
      DOI: 10.15386/mpr-985
      Issue No: Vol. 92, No. 2 (2019)
  • A comparative study of the accuracy of five CAD-CAM systems

    • Authors: Smaranda Buduru, Bogdan Culic, Daniel Talmaceanu, Adorjan Pal
      Pages: 185 - 191
      Abstract: Background and aims. The study aims at comparing the precision of different CAD/CAM systems: original systems built by the same manufacturer as opposed to systems whose components are built by different manufacturers. Methods. We used the same physical cast which was scanned with five different scanners. The design of the PMMA copings was done by the same operator for the five virtual casts. Each coping was milled three times by each milling machine, thus obtaining 75 copings. The internal space was analyzed by scanning the replicas in light body silicone. Results. The results analyzed the vertical marginal space (VMS) at the preparation limit, the axial internal space (AIS) and the internal occlusal space (IOS). For VMS the best results were obtained for scanner no 5 (S5) and milling machine 3 (M3). For AIS the best results were obtained with S4 and M3 combination. For IOS the best results were obtained with S45 and M3 combination. Conclusions. According to the results of the study, we are able to confirm the working hypothesis by stating the following conclusions: the quality of the prosthetic elements obtained through CAD/CAM processing differs depending on the CAD/CAM system used and is influenced by each component of every system individually, both the scanner and the milling unit; changing/switching any component of the CAD/CAM system has an impact on the quality of the resulting prosthetic work, but in an unpredictable manner.
      PubDate: 2019-01-15
      DOI: 10.15386/cjmed-1131
      Issue No: Vol. 92, No. 2 (2019)
  • Significance of Bottle Gourd sign on computed tomography in patients with
           abdominal cocoon: a case series

    • Authors: Vishal Sharma, Harshal S Mandavdhare, Harjeet Singh, Ujjwal Gorsi
      Pages: 192 - 194
      Abstract: Abdominal cocoon is an uncommon entity manifesting as abdominal pain, lump and features of intestinal obstruction. The diagnosis is established by demonstrating a membranous sac covering the small bowel loops which can be seen at the time of surgery or demonstrated by imaging studies like computed tomography (CT) or magnetic resonance imaging. CT has been reported to be of utility in making a preoperative diagnosis. The features may include clumped bowel loops, loculated fluid, cauliflower sign or concertina arrangement of bowel loops. We report on three cases of abdominal cocoon who presented with intestinal obstruction due to three varied etiologies (idiopathic, tuberculosis, malignancy). We also describe a radiological sign, the bottle gourd sign, in these three cases. The sign possibly suggests jejunal obstruction due to formation of abdominal cocoon.
      PubDate: 2019-04-24
      DOI: 10.15386/mpr-1147
      Issue No: Vol. 92, No. 2 (2019)
  • Bruising as the first sign of exocrine pancreatic insufficiency

    • Authors: Csilla Enikő Szabo, Oana Iulia Man, Radu Sorin Șerban, Eva Kiss, Călin Florin Lazăr
      Pages: 200 - 204
      Abstract: Exocrine pancreatic insufficiency is an important cause of chronic malnutrition, secondary to maldigestion-malabsorption, which can be caused in children especially by cystic fibrosis, but also by other much rarer diseases. The case of a 6 months and 3 weeks old male pediatric patient is reported, who was admitted to the clinic for head and forearms bruising. Laboratory findings identified vitamin K deficiency as the cause of the cutaneous hemorrhagic syndrome. Further investigations revealed association of steatorrhea (which is a marker of fat malabsorption), iron-deficiency anemia and hypovitaminosis D, which had been produced by nutritional deficiencies caused by malabsorption syndrome. From the numerous disorders that could be associated with pancreatic insufficiency in children, the following conditions had been excluded: cystic fibrosis (mucoviscidosis), cow`s milk protein intolerance, gluten-sensitive enteropathy (coeliac disease), Shwachman-Diamond syndrome, abetalipoproteinemia, etc. Based upon decreased levels of stool pancreatic elastase in repeated measurements, together with low serum lipase, the final diagnosis of exocrine pancreatic insufficiency was established. Treatment of this case consisted mainly in pancreatic enzyme replacement therapy, but also oral iron supplementation and dietary supplements with fat-soluble vitamins (A, D, E, K). The outcome was favorable, characterized by normalization of intestinal passage, ascending growth curve and normalization of the majority of laboratory tests values that were modified between the time of patient admission to our clinic and initiation of specific therapy (serum level of vitamin K, vitamin D and lipase, coagulation profile, hemoglobin and red blood cell indexes), as well as higher value of fecal pancreatic elastase.    

      PubDate: 2019-04-24
      DOI: 10.15386/mpr-1231
      Issue No: Vol. 92, No. 2 (2019)
  • Tuberculoza in cazuri clinice comentate [Tuberculosis by discussion of
           clinical cases] by Victor Botnaru

    • Authors: Doina Todea
      Pages: 208 - 209
      Abstract: Publisher “Balacron Printing House”, Chisinau 2018 ISBN 978-9975-3255-4-7 307 pages, 699 figures (photographs, tables and diagrams), 84 references
      PubDate: 2019-04-25
      Issue No: Vol. 92, No. 2 (2019)
  • Professor George Nicu Ionescu (1928-2019)

    • Authors: Irinel Popescu
      Pages: 210 - 210
      Abstract: .
      PubDate: 2019-04-25
      Issue No: Vol. 92, No. 2 (2019)
  • The obstetric complications in women with hereditary thrombophilia

    • Authors: Diana Mitriuc, Olga Popușoi, Rodica Catrinici, Valentin Friptu
      Pages: 106 - 110
      Abstract: All congenital thrombophilias are associated with an increased risk of venous thromboembolism (VTE) during pregnancy. Several studies have confirmed the increased risk of obstetric complications in women with congenital thrombophilias. Case-control, cohort and transversal studies have shown that hereditary thrombophilia is more prevalent in the cohorts of women with pregnancy losses, early onset preeclampsia, abruptio placentae and IUGR. However, despite the increase in the relative risk, the absolute risk of VTE and adverse pregnancy outcomes is low. There is convincing evidence that the deficiency of natural anticoagulants (AT, protein C, protein S) is a risk factor for late fetal loss. The mutations of the FVL (G1691A) gene and the prothrombin (G20210A) gene are associated with a double risk for unexplained RPL and non-recurrent late fetal loss. The association of congenital thrombophilia and preeclampsia is much more uncertain, being, probably, limited to the FVL G1691A gene mutation and more severe cases of preeclampsia. Fewer data are available for IUGR and abruptio placentae. In addition, genetic and epidemiological research suggest that obstetric complications during pregnancy have a polygenic multifactorial etiology, with a risk determined by the interaction of multiple genetic variants and other risk factors.
      PubDate: 2018-12-13
      DOI: 10.15386/cjmed-1097
      Issue No: Vol. 92, No. 2 (2018)
  • Short review on the diagnosis and treatment of bronchiectasis

    • Authors: Andrei Lesan, Alicia Elisabeth Lamle
      Pages: 111 - 116
      Abstract: Bronchiectasis refers to the permanent dilation of the bronchi. It is often a sequel of insufficiently treated lung disease that develops into a pathological pattern of dilated bronchi, which  heightens susceptibility to further lung infections. Modernization of diagnostic procedures (computed tomography scan) and definition of a clinical picture (repeated lung infections with a chronic cough and persistent sputum production) have raised international awareness of the prevalence of the disease, leading to increasing interest in reviewing and renewing the treatment guidelines. We selectively conducted a research on PubMed using the following keywords: “bronchiectasis”, “diagnosis”, “treatment”, “management”,  “antibiotics”. This review focuses solely on bronchiectasis not due to cystic fibrosis. All relevant articles published after the year of 2000 were included. The aim of this review is to provide an analytical update on the management of bronchiectasis, focusing on etiological factors as well as existing and developing treatment options for the disease.
      PubDate: 2018-12-21
      DOI: 10.15386/cjmed-1060
      Issue No: Vol. 92, No. 2 (2018)
  • The Birhor tribes of Ramgarh District, Jharkhand – a ferret into their
           oral health status and treatment needs

    • Authors: Gunjan Kumar, C L Dileep, Alok Kumar Sethi, Bhaskar Gupta
      Pages: 178 - 184
      Abstract: Aim and objectives. Jharkhand is a land of 32 listed Tribes, out of which eight tribes have been categorized as ‘Primitive Tribes’ and the Birhors are one among these. The study was aimed at assessing the oral health status and treatment needs of the native Birhors. Material and methods. A cross-sectional household survey of 400 Birhors in the panchayats of Basantpur, Kuju Purvi and Mandu Chatti was conducted. A modified World Health Organization (WHO) Oral Health Assessment Form (1997) was utilized and examined according to the WHO methodology (1997). The recorded data were statistically analyzed using the SPSS version 15.  Results. Based on the occupation, it was found that 141 (35.25%) subjects were hunters and 90 (22.50%) subjects practiced agriculture. A majority of 337 (84.25%) subjects were using the Sakhua twigs (Shorea robusta) to clean their teeth. It was observed that 381 (95.25%) subjects were quite healthy and had no oral mucosal lesions. Almost half of the study subjects (45%) were habituated to tobacco and among them 101 (56.11%) subjects were using khaini, followed by 46 (25.56%) subjects who used bidis. The mean decayed, missing, and filled teeth (DMFT) Index scores among males and females was 1.05±2.59 and 1.02±2.17, respectively. Subjects with bleeding gums were predominantly seen in the age group of 2-5 years (26.75%) and those with shallow pockets were more commonly seen in the age group of 16-34 years (47.12%). A total of 53 (13.25%) subjects and 33 (8.25%) subjects had a LOA of 4-5 mm and 6-8 mm, respectively. Among males, 0.44±2.60 subjects each needed one/two surface fillings. A total of 14 (3.5%) and 15 (3.75%) subjects needed one-unit prosthesis in the upper and lower jaws, respectively. Conclusion. The study showed that a majority of Birhor tribals (84.25%) used Sakhua twigs to clean their teeth. Almost half of the study subjects (45%) were habituated to tobacco in myriad forms.
      PubDate: 2018-12-21
      DOI: 10.15386/cjmed-1025
      Issue No: Vol. 92, No. 2 (2018)
  • Kimura disease: case report and brief review of literature

    • Authors: Harshi Dhingra, Ruchi Nagpal, Asif Baliyan, Sathyavathi R Alva
      Pages: 195 - 199
      Abstract: Kimura disease is a rare chronic inflammatory disorder of unknown cause, primarily seen in young Asian males. The disease is characterized by painless subcutaneous swelling, blood and tissue eosinophilia and raised IgE levels. Early diagnosis of Kimura’s disease may spare the patient from unnecessary invasive diagnostic procedure. We describe a case of Kimura disease in a 14-year old male presenting with left submandibular swelling and also provide a brief review of the literature.  
      PubDate: 2018-08-02
      DOI: 10.15386/cjmed-1030
      Issue No: Vol. 92, No. 2 (2018)
  • Is psychosomatic really a bicentennial word' The proof of an older use

    • Authors: Dan L. Dumitrascu, Liliana David, Adriana Baban
      Pages: 205 - 207
      Abstract: Background and aim. Psychosomatic medicine has different statuses in different countries and many physicians perceive it under various points of view. However, a common belief is that the father of the word psychosomatic is the German physician Johann Heinroth and that the word was coined in 1818. We looked for the history of the word psychosomatic to find out if this information is correct or not. Methods. The available literature was searched online and manually. We recorded available information and looked for other pertinent mentions of this word before 1818. Results. Although it is considered that the word psychosomatic is 200 years old, we found evidence that it had been used also in advance. Thus, the history of psychosomatic medicine is even longer. Here is the first report of a scientific work older than 1818. It is a PhD thesis published in Montpellier in 1784 by Marc Lemort Demétigny. Conclusions. The general belief is that the first use of the word psychosomatic happened 200 years ago. We found evidence that the word has an older usage.
      PubDate: 2018-12-13
      DOI: 10.15386/cjmed-1245
      Issue No: Vol. 92, No. 2 (2018)
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