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Reviews on Clinical Pharmacology and Drug Therapy
Number of Followers: 0  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1683-4100 - ISSN (Online) 2542-1875
Published by Eco-Vector LLC Homepage  [15 journals]
  • Biological activity of fullerenes - reality and prospects
         This is an Open Access Article Open Access Article

    • Authors: Marina A. Dumpis, Dmitrii N. Nikolayev, Elena V. Litasova, Viktor V. Iljin, Mariya A. Brusina, Levon B. Piotrovsky
      Pages: 4 - 20
      Abstract: Abstract. The review deals with the properties of fullerenes and their derivatives and the possibility of their use in biology and medicine. Fullerenes can exert an antioxidant effect in biological systems, catching active forms of oxygen, and oxidative, giving the fullerene photosensitizing properties. The lipophilic fullerene molecules possessing membrane — tropic action interact with various biological structures and can change the functions of these structures, increasing the lipophilicity of the active molecule (amino acids, nucleic acids, proteins, etc.). Data on the biological effect of fullerenes in in vitro and in vivo experiments are given. Examples of targeted delivery of known therapeutic agents.
      PubDate: 2018-03-15
      DOI: 10.17816/RCF1614-20
      Issue No: Vol. 16, No. 1 (2018)
       
  • Autism spectrum disorders: etiology, treatment. models and experimental
           studies

         This is an Open Access Article Open Access Article

    • Authors: Nikanor V. Lavrov, Petr D. Shabanov
      Pages: 21 - 27
      Abstract: Abstract. The study of disorders of brain activity related to the violation of socialization is the current scientific problem. The article presents a review of the literature regarding the epidemiology, etiology and treatment of autism spectrum disorders. Special attention is paid to experimental models of autism, since simulation allows to test hypotheses about the nature of the disease and to carry out testing of new treatment methods.
      PubDate: 2018-03-15
      DOI: 10.17816/RCF16121-27
      Issue No: Vol. 16, No. 1 (2018)
       
  • The study of the effects of dipeptide mimetic of a brain derived
           neurotrophic factor with antidepressant activity during prolonged use and
           after withdrawal

         This is an Open Access Article Open Access Article

    • Authors: Taisiya L. Garibova, Valentina A. Krayneva, Elena A. Valdman, Tatyana A. Gudasheva, Svetlana O. Kotelnikova, Sergey B. Seredenin
      Pages: 28 - 33
      Abstract: Abstract. The antidepressant activity of the GSB-106, dipeptide mimetic of the 4th loop of BDNF, during long-term use was studied in doses of 1.0 mg/kg and 5 mg/kg for. When comparing antidepressant activity in the “forced swimming Porsolt test” on the 14th and 28th day of administration, it was established that the antidepressant effect did not change. It was shown that a withdrawal of prolonged administration for 28 days did not lead to an increase in anxiety in the “elevated plus-maze test” and to the development of disturbances in the exploratory behavior of animals and motor activity in the “open field” test. It was concluded that during long-term administration of GSB-106 the tolerance for the main antidepressant effect did not developed, and cessation of long-term administration of GSB-106 did not lead to the development of withdrawal syndrome.
      PubDate: 2018-03-15
      DOI: 10.17816/RCF16128-33
      Issue No: Vol. 16, No. 1 (2018)
       
  • Effect of SB-408124, an orexin A OX1R receptor antagonist, on the
           compulsive behavior and the level of anxiety after the vital stress in
           rats

         This is an Open Access Article Open Access Article

    • Authors: Ilia Yu. Tissen, Natalia D. Yakushina, Andrei A. Lebedev, Anna G. Pshenichnaya, Eugenii R. Bychkov, Sergei G. Tsykunov, Petr D. Shabanov
      Pages: 34 - 42
      Abstract: Abstract. The effect of the orexin A OX1R receptor antagonist SB-408124 of on the compulsive behavior and the anxiety in rats after the presentation of vital stress in a number of behavioral tests: marble test, elevated plus maze, in the open field and in the test “resident intruder”. In the buring marble test, the behavioral components of the obsession  (obsessive  and obtrusive thoughts) and compulsions (obtrusive behavior), aimed to reduce anxiety, were modeled. Mental trauma was caused by a stressful effect, the essence of which was the experience of the animals of the circumstances of the death of a partner from the actions of a predator. A group of rats were placed once in the terrarium to a tiger python. After the action of vital mental stress in rats, two connected behavioral phenomena were observed: a high level of anxiety and an increase in the number of buried balls. This was accompanied by a decrease in communicability. Intranasal administration (for 7 days) of orexin A antagonist OX1R receptor SB-408124 after presentation of the vital stress reduced the level of anxiety, and also normalized the communicative activity of animals and the number of buried balls, i.e. compulsive behavior. Thus, the orexin system of the brain is an important component of psychotraumatic mechanism. OX1R antagonists of orexin A receptors can potentially be considered as correctors of obsessive-compulsive disorders on the background of posttraumatic stress disorder (PTSD). Use of intranasal administration of OX1R antagonists of orexin A receptors in the clinic will allow the use of small doses of substances and thereby reduce their possible toxic effects.
      PubDate: 2018-03-15
      DOI: 10.17816/RCF16134-42
      Issue No: Vol. 16, No. 1 (2018)
       
 
 
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