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Journal Cover
Cell Chemical Biology
Journal Prestige (SJR): 3.174
Citation Impact (citeScore): 5
Number of Followers: 1  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Online) 2451-9456
Published by Elsevier Homepage  [3163 journals]
  • Cells Stiffen for Cytokines
    • Authors: Richard Newton; Daniel J. Müller
      Pages: 495 - 496
      Abstract: In this issue of Cell Chemical Biology, Knoops et al. (2018) use a novel approach in immunology: combining confocal microscopy and atomic force microscopy to unravel the specific interaction of oxidized peroxiredoxin-5 with Toll-like receptor 4 that leads to the release of interleukin-1β and the stiffening of mammalian cells.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.05.006
      Issue No: Vol. 25, No. 5 (2018)
  • Shining a Light on Alport Syndrome
    • Authors: Lorna J. Hale; Melissa H. Little
      Pages: 497 - 498
      Abstract: In this issue of Cell Chemical Biology, Omachi et al. (2018) present a split Nanoluciferase system to identify successful protein trimerization in Alport syndrome. This elegant proof of concept suggests opportunities for drug screening for Alport syndrome and may be transferable to the study of other diseases affecting protein-protein interactions.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.05.001
      Issue No: Vol. 25, No. 5 (2018)
  • Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and
    • Authors: Jun Li; Hui-Chen Hsu, John D. Mountz, John G. Allen
      Pages: 499 - 512
      Abstract: Fucose occurs very specifically in cell-surface glycan and may be thought of as a privileged sugar residue in glycobiology. Fucose is necessary for many critical cell adhesion and signaling events. Genetic modulation or modulation by fucose-specific reagents has revealed exciting new biology and opened new opportunities for the treatment of human diseases. In this review, Li et al. describe the tools used to discover new fucose biology, its impact on living systems, and initial clinical trial results.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-08
      DOI: 10.1016/j.chembiol.2018.02.005
      Issue No: Vol. 25, No. 5 (2018)
  • The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts
           the TPR Helix
    • Authors: Mehmet Gundogdu; Salomé Llabrés, Andrii Gorelik, Andrew T. Ferenbach, Ulrich Zachariae, Daan M.F. van Aalten
      Pages: 513 - 518.e4
      Abstract: Gundogdu et al. demonstrate how the intellectual disability-associated mutation in O-GlcNAc transferase (OGT), L254F, leads not only to large shifts in OGT structure and altered dynamics in solution, but also a non-specific reduction in activity, providing the first molecular characterization of such a mutation.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.chembiol.2018.03.004
      Issue No: Vol. 25, No. 5 (2018)
  • Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and
           Reaction Mechanism
    • Authors: Seema Irani; Nathchar Naowarojna, Yang Tang, Karan R. Kathuria, Shu Wang, Anxhela Dhembi, Norman Lee, Wupeng Yan, Huijue Lyu, Catherine E. Costello, Pinghua Liu, Yan Jessie Zhang
      Pages: 519 - 529.e4
      Abstract: Irani et al. have determined the structure of Egt2, a C-S lyase at the final step in the ergothioneine biosynthesis pathways. Using X-ray crystallography and various biochemical studies, the reaction mechanism was delineated.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-01
      DOI: 10.1016/j.chembiol.2018.02.002
      Issue No: Vol. 25, No. 5 (2018)
  • The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein
           Synthesis by Targeting the Bacterial Ribosome
    • Authors: Mario Mardirossian; Natacha Pérébaskine, Monica Benincasa, Stefano Gambato, Sven Hofmann, Paul Huter, Claudia Müller, Kai Hilpert, C. Axel Innis, Alessandro Tossi, Daniel N. Wilson
      Pages: 530 - 539.e7
      Abstract: Proline-rich antimicrobial peptides (PrAMPs) are antibacterial components of the immune system of some animals. Mardirossian et al. identified two PrAMPs in the artiodactyl Tursiops truncatus (bottlenose dolphin), Tur1A and Tur1B. Tur1A was shown to inhibit bacterial protein synthesis by binding to the ribosome.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-08
      DOI: 10.1016/j.chembiol.2018.02.004
      Issue No: Vol. 25, No. 5 (2018)
  • Analysis of the Pseudouridimycin Biosynthetic Pathway Provides Insights
           into the Formation of C-nucleoside Antibiotics
    • Authors: Margherita Sosio; Eleonora Gaspari, Marianna Iorio, Silvia Pessina, Marnix H. Medema, Alice Bernasconi, Matteo Simone, Sonia I. Maffioli, Richard H. Ebright, Stefano Donadio
      Pages: 540 - 549.e4
      Abstract: Sosio et al. describe the biosynthetic pathway for the C-nucleoside antibiotic pseudouridimycin. Biosynthesis proceeds through formation of pseudouridine by the pseudouridine synthase PumJ, with specialized oxidoreductase, aminotransferase, and amide ligases leading to the final compound. Microbial genomes harbor diverse gene clusters encoding PumJ-related sequences.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-15
      DOI: 10.1016/j.chembiol.2018.02.008
      Issue No: Vol. 25, No. 5 (2018)
  • Specific Interactions Measured by AFM on Living Cells between
           Peroxiredoxin-5 and TLR4: Relevance for Mechanisms of Innate Immunity
    • Authors: Bernard Knoops; Sarah Becker, Mégane Anne Poncin, Julien Glibert, Sylvie Derclaye, André Clippe, David Alsteens
      Pages: 550 - 559.e3
      Abstract: Knoops et al. used force-distance curve-based atomic force microscopy to investigate the molecular mechanisms by which extracellular human PRDX5 can activate a proinflammatory response. Single-molecule experiments demonstrate specific binding of PRDX5 to TLR4 on purified receptors and living cells.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-15
      DOI: 10.1016/j.chembiol.2018.02.006
      Issue No: Vol. 25, No. 5 (2018)
  • Biosynthesis and Activity of Prenylated FMN Cofactors
    • Authors: Po-Hsiang Wang; Anna N. Khusnutdinova, Fei Luo, Johnny Xiao, Kayla Nemr, Robert Flick, Greg Brown, Radhakrishnan Mahadevan, Elizabeth A. Edwards, Alexander F. Yakunin
      Pages: 560 - 570.e6
      Abstract: Wang et al. characterized the biosynthetic origin of the prenyl donor of prenylated FMN in E. coli, a newfound cofactor involved in ubiquinone biosynthesis and lignin biodegradation. They developed methods to produce free prenylated FMN species. These findings suggested a novel metabolic link between the isoprenoid pathway and ubiquinone biosynthesis.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-15
      DOI: 10.1016/j.chembiol.2018.02.007
      Issue No: Vol. 25, No. 5 (2018)
  • Dual Modifications of α-Galactosylceramide Synergize to Promote
           Activation of Human Invariant Natural Killer T Cells and Stimulate
           Anti-tumor Immunity
    • Authors: Divya Chennamadhavuni; Noemi Alejandra Saavedra-Avila, Leandro J. Carreño, Matthew J. Guberman-Pfeffer, Pooja Arora, Tang Yongqing, Hui-Fern Koay, Dale I. Godfrey, Santosh Keshipeddy, Stewart K. Richardson, Srinivasan Sundararaj, Jae Ho Lo, Xiangshu Wen, José A. Gascón, Weiming Yuan, Jamie Rossjohn, Jérôme Le Nours, Steven A. Porcelli, Amy R. Howell
      Pages: 571 - 584.e8
      Abstract: Chennamadhavuni et al. synthesized an improved activating ligand for iNKT cells by combining carbohydrate and sphingoid base modifications in an α-galactosyl ceramide. Biological and structural studies provide insight into the mechanisms responsible for improved activity and suggest approaches for further optimization of ligand design.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-22
      DOI: 10.1016/j.chembiol.2018.02.009
      Issue No: Vol. 25, No. 5 (2018)
  • Copper-Binding Small Molecule Induces Oxidative Stress and Cell-Cycle
           Arrest in Glioblastoma-Patient-Derived Cells
    • Authors: Kenichi Shimada; Eduard Reznik, Michael E. Stokes, Lakshmi Krishnamoorthy, Pieter H. Bos, Yuyu Song, Christine E. Quartararo, Nen C. Pagano, Darren R. Carpizo, Ana C. deCarvalho, Donald C. Lo, Brent R. Stockwell
      Pages: 585 - 594.e7
      Abstract: Shimada et al. report that the compound NSC319726 arrests glioblastoma-patient-derived cells at picomolar concentrations. The compound binds to copper, generates ROS using ambient oxygen, and depletes nucleotide pools. This represents a new strategy for potently blocking the growth of glioblastoma.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-22
      DOI: 10.1016/j.chembiol.2018.02.010
      Issue No: Vol. 25, No. 5 (2018)
  • Aggregated Aβ1-42 Is Selectively Toxic for Neurons, Whereas Glial Cells
           Produce Mature Fibrils with Low Toxicity in Drosophila
    • Authors: Maria Jonson; Sofie Nyström, Alexander Sandberg, Marcus Carlback, Wojciech Michno, Jörg Hanrieder, Annika Starkenberg, K. Peter R. Nilsson, Stefan Thor, Per Hammarström
      Pages: 595 - 610.e5
      Abstract: Jonson et al. used transgenic Drosophila to understand cell-specific response to protein aggregates in neurodegenerative disease. They demonstrate that the Alzheimer-associated peptide Aβ1-42 form various amyloid structures with different toxic properties when expressed in different cell types of the brain.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.chembiol.2018.03.006
      Issue No: Vol. 25, No. 5 (2018)
  • Repurposing High-Throughput Image Assays Enables Biological Activity
           Prediction for Drug Discovery
    • Authors: Jaak Simm; Günter Klambauer, Adam Arany, Marvin Steijaert, Jörg Kurt Wegner, Emmanuel Gustin, Vladimir Chupakhin, Yolanda T. Chong, Jorge Vialard, Peter Buijnsters, Ingrid Velter, Alexander Vapirev, Shantanu Singh, Anne E. Carpenter, Roel Wuyts, Sepp Hochreiter, Yves Moreau, Hugo Ceulemans
      Pages: 611 - 618.e3
      Abstract: Simm et al. demonstrate a computational method to predict the activities of compounds in hundreds of biological assays from a single image-based screen of half a million compounds. The resulting models boosted the identification and diversity of hit compounds for two projects, encouraging further research in this field.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-01
      DOI: 10.1016/j.chembiol.2018.01.015
      Issue No: Vol. 25, No. 5 (2018)
  • Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for
           Revealing Personalized Markers in Precision Prognosis of Cancer
    • Authors: Li Wang; John A. Wrobel, Ling Xie, DongXu Li, Giada Zurlo, Huali Shen, Pengyuan Yang, Zefeng Wang, Yibing Peng, Harsha P. Gunawardena, Qing Zhang, Xian Chen
      Pages: 619 - 633.e5
      Abstract: The interpatient tumor-phenotypic heterogeneity hinders discovery of biomarkers for individualized prognosis. Wang and colleagues introduce an alternative splicing activity-based proteogenomic method that dissects tumor heterogeneity for de novo discovery of individualized prognostic biomarkers. The resulting biomarkers distinguish high-risk patient subpopulations from other patients within each single breast cancer subtype.
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-01
      DOI: 10.1016/j.chembiol.2018.01.016
      Issue No: Vol. 25, No. 5 (2018)
  • A Split-Luciferase-Based Trimer Formation Assay as a High-throughput
           Screening Platform for Therapeutics in Alport Syndrome
    • Authors: Kohei Omachi; Misato Kamura, Keisuke Teramoto, Haruka Kojima, Tsubasa Yokota, Shota Kaseda, Jun Kuwazuru, Ryosuke Fukuda, Kosuke Koyama, Shingo Matsuyama, Keishi Motomura, Tsuyoshi Shuto, Mary Ann Suico, Hirofumi Kai
      Pages: 634 - 643.e4
      Abstract: Omachi et al. showed that the type IV collagen α345(IV) trimer is a therapeutic target for the hereditary kidney disease, Alport syndrome. They established an HTS-applicable α345(IV) trimer assay and showed that chemical chaperones rescued trimer formation of mutant α5(IV).
      Citation: Cell Chemical Biology 25, 5 (2018)
      PubDate: 2018-03-08
      DOI: 10.1016/j.chembiol.2018.02.003
      Issue No: Vol. 25, No. 5 (2018)
  • A Proposed Mechanism for Neurodegeneration in Movement Disorders
           Characterized by Metal Dyshomeostasis and Oxidative Stress
    • Authors: Benjamin Guy Trist; Dominic James Hare, Kay Lorraine Double
      Abstract: Trist et al. propose a shared etiological pathway in Parkinson disease and SOD1-associated familial amyotrophic lateral sclerosis, whereby concomitant changes in cellular copper and oxidative stress within dying neurons contribute to the dysfunction of specific proteins that are essential for maintaining neuronal health, including superoxide dismutase 1.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.004
  • Protein Lipidation in Cell Signaling and Diseases: Function, Regulation,
           and Therapeutic Opportunities
    • Authors: Baoen Chen; Yang Sun, Jixiao Niu, Gopala K. Jarugumilli, Xu Wu
      Abstract: We highlight recent progress in our understanding of protein lipidation, in particular, S-palmitoylation, and describe the importance of protein lipidation in cell signaling and diseases. We further highlight opportunities and new strategies for targeting protein lipidation for therapeutic applications.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.003
  • Redefining the Protein Kinase Conformational Space with Machine Learning
    • Authors: Peter Man-Un Ung; Rayees Rahman, Avner Schlessinger
      Abstract: Ung and Rahman et al. constructed a machine-learning-based algorithm to refine the current classification of protein kinase structures into active and inactive conformations. Analysis of the small molecules recognized by each conformation captures conformation-specific chemical substructures.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.002
  • PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage
    • Authors: Kimberly Pistorius; Patricia R. Souza, Roberta De Matteis, Shani Austin-Williams, Karoline G. Primdahl, Anders Vik, Francesca Mazzacuva, Romain A. Colas, Raquel M. Marques, Trond V. Hansen, Jesmond Dalli
      Abstract: Pistorius et al., found that a recently uncovered family of bioactive mediators termed PDn-3 DPA controls human macrophage phenotype and function during their differentiation from monocytes. The authors also established the biosynthetic pathway for this family of mediators thereby providing leads into mechanisms that control macrophage responses.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.017
  • Convergent Use of Heptacoordination for Cation Selectivity by RNA and
           Protein Metalloregulators
    • Authors: Sharrol T. Bachas; Adrian R. Ferré-D'Amaré
      Abstract: Bachas and Ferré-D'Amaré demonstrate how the broad family of yybP-ykoY riboswitches use heptacoordination to selectively bind transition metal ions. Heptacoordination is further generalized as a convergent selectivity mechanism used by protein and RNA metalloregulators that sense similar transition metals.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.016
  • Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes
    • Authors: Lena Rakers; David Grill, Anna L.L. Matos, Stephanie Wulff, Da Wang, Jonas Börgel, Martin Körsgen, Heinrich F. Arlinghaus, Hans-Joachim Galla, Volker Gerke, Frank Glorius
      Abstract: Cholesterol is an important component of biological membranes, but probes recording its dynamic intracellular distribution are scarce. Rakers et al. developed cholesterol-derived imidazolium salts mimicking properties of natural cholesterol. Following specific labeling via click chemistry, one of the cholesterol analogs was shown to incorporate into cellular membranes equivalent to endogenous cholesterol.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.015
  • Structure-based Engineering of a Plant-Fungal Hybrid Peroxidase for
           Enhanced Temperature and pH Tolerance
    • Authors: Amanda C. Kohler; Blake A. Simmons, Kenneth L. Sale
      Abstract: Kohler et al. describe a rational engineering approach for the direct design of innovative, industrially tailored biocatalysts. They utilize this approach to address the current application barrier of high-reduction potential peroxidases as oxidative tools, building a catalytically versatile plant-fungal hybrid peroxidase capable of functioning under wider temperature and pH ranges.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.014
  • Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of
           Sulfonylfluoride Peptidomimetics
    • Authors: Salvador Guardiola; Roger Prades, Laura Mendieta, Arwin J. Brouwer, Jelle Streefkerk, Laura Nevola, Teresa Tarragó, Rob M.J. Liskamp, Ernest Giralt
      Abstract: Prolyl oligopeptidase (POP) is a neuronal enzyme involved in cognitive disorders. By combining a peptidomimetic scaffold with a mild electrophile, Guardiola et al. designed highly active covalent inhibitors that are not only potent and selective but display optimal properties for accessing the brain by passive diffusion.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.013
  • Construction of Fluorescent Analogs to Follow the Uptake and Distribution
           of Cobalamin (Vitamin B12) in Bacteria, Worms, and Plants
    • Authors: Andrew D. Lawrence; Emi Nemoto-Smith, Evelyne Deery, Joseph A. Baker, Susanne Schroeder, David G. Brown, Jennifer M.A. Tullet, Mark J. Howard, Ian R. Brown, Alison G. Smith, Helena I. Boshoff, Clifton E. Barry, Martin J. Warren
      Abstract: Lawrence et al., employed chemical biology approaches to construct a range of fluorescent vitamin B12 derivatives. They demonstrated that these fluorescent variants can be used to follow intracellular B12 trafficking in bacteria, including E. coli and M. tuberculosis, the worm C. elegans, and a higher plant (Lepidium sativum).
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.012
  • De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry
    • Authors: Toby Passioura; Koichi Watashi, Kento Fukano, Satomi Shimura, Wakana Saso, Ryo Morishita, Yuki Ogasawara, Yasuhito Tanaka, Masashi Mizokami, Camille Sureau, Hiroaki Suga, Takaji Wakita
      Abstract: Hepatitis B virus infection causes serious illness and current treatments are not curative. In this work, Passioura et al. describe diverse small macrocyclic peptides that bind to the cellular receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP), and block viral entry without affecting NTCP's taurocholate transporting activity.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.011
  • Linking Genomic and Metabolomic Natural Variation Uncovers Nematode
           Pheromone Biosynthesis
    • Authors: Jan M. Falcke; Neelanjan Bose, Alexander B. Artyukhin, Christian Rödelsperger, Gabriel V. Markov, Joshua J. Yim, Dominik Grimm, Marc H. Claassen, Oishika Panda, Joshua A. Baccile, Ying K. Zhang, Henry H. Le, Dino Jolic, Frank C. Schroeder, Ralf J. Sommer
      Abstract: A small-molecule library, the ascarosides, regulates the life history of Caenorhabditis elegans and Pristionchus pacificus. GWAS combined with metabolomics of P. pacificus natural isolates revealed a putative carboxylesterase, Ppa-uar-1, involved in attaching a pyrimidine-derived moiety in the biosynthesis of a major dauer pheromone component.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.004
  • Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues
           F508del-CFTR in Cystic Fibrosis Airway Epithelia
    • Authors: Elvira Sondo; Federico Falchi, Emanuela Caci, Loretta Ferrera, Elisa Giacomini, Emanuela Pesce, Valeria Tomati, Sine Mandrup Bertozzi, Luca Goldoni, Andrea Armirotti, Roberto Ravazzolo, Andrea Cavalli, Nicoletta Pedemonte
      Abstract: Sondo et al. used a computational approach to identify an inhibitor, named inh-02, for RNF5 ubiquitin ligase. RNF5 detects the misfolding of a mutant CFTR in cystic fibrosis. Inh-2 decreases ubiquitylation and rescues F508del-CFTR on human primary bronchial epithelia. This work validates RNF5 as a drug target for cystic fibrosis.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.010
  • Structural Insights into Subunits Assembly and the Oxyester Splicing
           Mechanism of Neq pol Split Intein
    • Authors: Verónica Gordo; David Aparicio, Rosa Pérez-Luque, Antoni Benito, Maria Vilanova, Isabel Usón, Ignacio Fita, Marc Ribó
      Abstract: Gordo et al. have determined the crystal structures of both the isolated NeqN subunit and the NeqN/NeqC complex. In these structures, Neq pol subunits carry the intein wild-type sequences, including the essential catalytic residues Ser1 and Thr+1, together with several residues from the N- and C-exteins.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.008
  • Measuring Endoplasmic Reticulum Signal Sequences Translocation Efficiency
           Using the Xbp1 Arrest Peptide
    • Authors: Theresa Kriegler; Anastasia Magoulopoulou, Rocio Amate Marchal, Tara Hessa
      Abstract: Kriegler et al. measured functional efficiency of ER signal sequences by using stalled ribosome-nascent chains derived from the Xbp1 arrest peptide. Efficiencies are measured as “pulling forces”, whereby an efficient signal sequence generates two pulling events while an inefficient signal sequence experiences a single one, reflecting its incomplete engagement.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.006
  • Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA
    • Authors: Bastian Vögeli; Kyra Geyer, Patrick D. Gerlinger, Sarah Benkstein, Niña Socorro Cortina, Tobias J. Erb
      Abstract: Vögeli et al. present a chemo-biosynthetic strategy that employs biocatalytic proofreading and allows production of a large variety of alkylmalonyl-CoA extender units by utilizing a promiscuous acyl-CoA oxidase and an engineered promiscuous enoyl-CoA carboxylase/reductase. The extender units are used to test the substrate specificity of the polyketide synthase DEBS.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.009
  • Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase
    • Authors: Carlos Moreno-Yruela; Iacopo Galleano, Andreas S. Madsen, Christian A. Olsen
      Abstract: Moreno-Yruela et al. show that histone deacetylase 11 (HDAC11) cleaves long-chain acyl modifications on lysine side chains with remarkable efficiency, and macrocyclic hydroxamic acid-containing peptides potently inhibit HDAC11 demyristoylation. These findings provide a foundation for future development of selective chemical probes targeting HDAC11.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.007
  • Mechanism of Allosteric Coupling into and through the Plasma Membrane by
    • Authors: Julie K.L. Sinclair; Allison S. Walker, Amy E. Doerner, Alanna Schepartz
      Abstract: The mechanism by which EGFR communicates growth factor-dependent signals to the cell interior is unknown. Here we show that growth factor identity is encoded into discrete TM helix dimers. These dimers induce different coiled-coil structures within the JM region that correlate with downstream signaling.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.005
  • Mitochondria Export Sulfur Species Required for Cytosolic tRNA Thiolation
    • Authors: Alok Pandey; Jayashree Pain, Nathaniel Dziuba, Ashutosh K. Pandey, Andrew Dancis, Paul A. Lindahl, Debkumar Pain
      Abstract: Critical signals and metabolites move between mitochondria and cytosol, and such communications are essential for cellular homeostasis. Pandey et al. demonstrate that mitochondria generate activated sulfur intermediates (Sint). The intermediates are exported to the cytosol in an ATP-dependent fashion, and there they are utilized for thio-modification of tRNAs.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.chembiol.2018.04.002
  • Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human
           Oligodendrocyte Differentiation
    • Authors: Nicole Merten; Julia Fischer, Katharina Simon, Liguo Zhang, Ralf Schröder, Lucas Peters, Anne-Gaelle Letombe, Stephanie Hennen, Ramona Schrage, Theresa Bödefeld, Celine Vermeiren, Michel Gillard, Klaus Mohr, Qing Richard Lu, Oliver Brüstle, Jesus Gomeza, Evi Kostenis
      Abstract: Identification of alternative uses for existing drugs is a hot topic in drug discovery. Merten et al. repurposed the experimental drug HAMI3379, originally developed to treat cardiovascular and inflammatory disorders, for pharmacological exploitation of orphan GPR17, and thereby enhance regenerative strategies for promotion of remyelination in patients.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.chembiol.2018.03.012
  • Structural Lipids Enable the Formation of Functional Oligomers of the
           Eukaryotic Purine Symporter UapA
    • Authors: Euan Pyle; Antreas C. Kalli, Sotiris Amillis, Zoe Hall, Andy M. Lau, Aylin C. Hanyaloglu, George Diallinas, Bernadette Byrne, Argyris Politis
      Abstract: We describe the first in-depth analysis of membrane lipid interactions with a eukaryotic transporter using native mass spectrometry. We demonstrate that the binding of structural lipids is essential to maintain the stability of the functional UapA dimer in both the gas phase and in vivo.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.011
  • A Designed Peptide Targets Two Types of Modifications of p53 with
           Anti-cancer Activity
    • Authors: Lunxi Liang; Huanbin Wang, Hubing Shi, Zhaoli Li, Han Yao, Zhigao Bu, Ningning Song, Chushu Li, Dabin Xiang, Yao Zhang, Jilin Wang, Ye Hu, Qi Xu, Yanlei Ma, Zhongyi Cheng, Yingchao Wang, Shuliang Zhao, Jin Qian, Yingxuan Chen, Jing-Yuan Fang, Jie Xu
      Abstract: Liang et al. describe a designed peptide that regulates two types of post-translational modifications of p53 with anti-cancer effect, based on the identification of a Morn3-mediated protein complex that confers composite modifications on p53. The findings highlight a strategy for targeting composite protein modifications with one molecule.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.010
  • Site-Specific Three-Color Labeling of α-Synuclein via Conjugation to
           Uniquely Reactive Cysteines during Assembly by Native Chemical Ligation
    • Authors: Taehyung C. Lee; Crystal R. Moran, Philip A. Cistrone, Philip E. Dawson, Ashok A. Deniz
      Abstract: Lee and Moran et al. present a strategy for fully site-specific labeling of the intrinsically disordered protein α-synuclein with three fluorophores for multi-color single-molecule FRET. This expandable method uses standard maleimide-cysteine chemistry, and enables more global investigation of complex proteins and their dynamic interactions.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.009
  • Structural Determinants for Small-Molecule Activation of Skeletal Muscle
           AMPK α2β2γ1 by the Glucose Importagog SC4
    • Authors: Kevin R.W. Ngoei; Christopher G. Langendorf, Naomi X.Y. Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A. Camerino, Scott R. Walker, Ylva E. Bozikis, Toby A. Dite, Ashley J. Ovens, William J. Smiles, Roxane Jacobs, He Huang, Michael W. Parker, John W. Scott, Mark H. Rider, Richard C. Foitzik, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill
      Abstract: Therapeutic activation of the metabolic regulator AMPK in skeletal muscle is a validated strategy to combat type 2 diabetes. Ngoei et al. have solved the crystal structure of the activator SC4 complexed to a skeletal muscle AMPK isoform, identifying important binding determinants that will advance development of AMPK-targeting therapeutics.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.chembiol.2018.03.008
  • Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that
           Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis
    • Authors: Qingfei Zheng; Yukang Gong, Yujiao Guo, Zhixiong Zhao, Zhuhua Wu, Zixuan Zhou, Dandan Chen, Lifeng Pan, Wen Liu
      Abstract: Zheng et al. provide structural and mechanistic insights into PyrE3, a flavin-dependent cyclase that does not require flavin redox change during the process of catalyzing an endo-selective Diels-Alder-like [4 + 2] cycloaddition, thereby generating interest regarding the versatile functions of flavoenzymes that have not been fully appreciated.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.chembiol.2018.03.007
  • Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic
           Lethal Vulnerability in Mutant KRAS-Driven Cancers
    • Authors: Malvika Koundinya; Judith Sudhalter, Albane Courjaud, Bruno Lionne, Gaetan Touyer, Luc Bonnet, Isabelle Menguy, Isabelle Schreiber, Christelle Perrault, Stephanie Vougier, Brigitte Benhamou, Bailin Zhang, Timothy He, Qiang Gao, Patricia Gee, Daniel Simard, M. Paola Castaldi, Ronald Tomlinson, Stephan Reiling, Matthieu Barrague, Richard Newcombe, Hui Cao, Yanjun Wang, Fangxian Sun, Joshua Murtie, Mark Munson, Eric Yang, David Harper, Monsif Bouaboula, Jack Pollard, Claudine Grepin, Carlos Garcia-Echeverria, Hong Cheng, Francisco Adrian, Christopher Winter, Stuart Licht, Ivan Cornella-Taracido, Rosalia Arrebola, Aaron Morris
      Abstract: Koundinya et al. show that inhibitors of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase selectively inhibit the growth of KRAS mutant cell lines. Differential sensitivity of the mutant lines correlates with differential effects of the inhibitors on primary energy metabolism and glutamine levels, and the inhibitors synergize with some clinically used anticancer agents.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.005
  • Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution
    • Authors: Song Ding; Colin P. O'Banion, Joshua G. Welfare, David S. Lawrence
      Abstract: Cells have been used to restrain, convey, and release therapeutic agents. This review highlights the strategies associated with the design and implantation of cell-based drug delivery platforms.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.003
  • The Rheumatoid Arthritis-Associated Citrullinome
    • Authors: Ronak Tilvawala; Son Hong Nguyen, Aaron J. Maurais, Venkatesh V. Nemmara, Mitesh Nagar, Ari J. Salinger, Sunil Nagpal, Eranthie Weerapana, Paul R. Thompson
      Abstract: Tilvawala et al. demonstrated that protein citrullination is elevated in RA and defined the RA-associated citrullinome. Tilvawala et al. further discovered that Serpin citrullination abolishes their ability to inhibit their cognate proteases. These studies open a new avenue to understand the links between protein citrullination and numerous diseases.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.002
  • Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic
           Nonribosomal Peptide Synthetase
    • Authors: Martin Klapper; Daniel Braga, Gerald Lackner, Rosa Herbst, Pierre Stallforth
      Abstract: Nonribosomal peptides are a diverse class of ecologically and clinically relevant natural products. Here, Klapper et al. study one of the simplest bacterial nonribosomal peptide synthetases of different Pseudomonas strains. A single gene, encoding the monomodular pyreudione synthetase, leads to the production of a variety of bioactive alkaloids.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.chembiol.2018.02.013
  • Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain
           to Interrupt BRCA1-Dependent Signaling
    • Authors: Jayaprakash Periasamy; Vadiraj Kurdekar, Subbarao Jasti, Mamatha B. Nijaguna, Sanjana Boggaram, Manjunath A. Hurakadli, Dhruv Raina, Lokavya Meenakshi Kurup, Chetan Chintha, Kavyashree Manjunath, Aneesh Goyal, Gayathri Sadasivam, Kavitha Bharatham, Muralidhara Padigaru, Vijay Potluri, Ashok R. Venkitaraman
      Abstract: Periasamy et al. report the development of Bractoppin, a drug-like inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain, opening avenues to block intracellular signaling via a family of related targets.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.chembiol.2018.02.012
  • Structural Insights into the Forward and Reverse Enzymatic Reactions in
           Human Adenine Phosphoribosyltransferase
    • Authors: Jessica Huyet; Mohammad Ozeir, Marie-Claude Burgevin, Benoît Pinson, Françoise Chesney, Jean-Marc Remy, Abdul Rauf Siddiqi, Roland Lupoli, Gregory Pinon, Christelle Saint-Marc, Jean-Francois Gibert, Renaud Morales, Irène Ceballos-Picot, Robert Barouki, Bertrand Daignan-Fornier, Anne Olivier-Bandini, Franck Augé, Pierre Nioche
      Abstract: APRT is a key enzyme in the purine salvage pathway in prokaryotes and eukaryotes. Huyet et al., by using in vitro, cellular, and in crystallo enzymatic analyses, reveal that a hydroxyl group in a conserved tyrosine controls the protein dynamics and the catalytic efficiencies of the forward and reverse reactions.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-22
      DOI: 10.1016/j.chembiol.2018.02.011
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