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Cell Chemical Biology
Journal Prestige (SJR): 3.174
Citation Impact (citeScore): 5
Number of Followers: 3  
  Hybrid Journal Hybrid journal (It can contain Open Access articles)
ISSN (Online) 2451-9456
Published by Elsevier Homepage  [3155 journals]
  • Sulfur from Within: Cytosolic tRNA Thiouridinylation
    • Authors: Joseph J. Braymer; Dennis R. Winge
      Pages: 645 - 647
      Abstract: In this issue of Cell Chemical Biology, Pandey et al. (2018) identified that mitochondrial cysteine desulfurase provides the sulfur species used for tRNALys, tRNAGlu, and tRNAGln thiouridine modification in the cytoplasm. A low-mass sulfur species is exported by the mitochondrial Atm1 transporter and utilized in the thio-modifications.
      Citation: Cell Chemical Biology 25, 6 (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.chembiol.2018.06.003
      Issue No: Vol. 25, No. 6 (2018)
  • Synthetic Immunotherapeutics against Gram-negative Pathogens
    • Authors: Mary Sabulski Feigman; Seonghoon Kim, Sean E. Pidgeon, Yuming Yu, George Mogambi Ongwae, Dhilon S. Patel, Steven Regen, Wonpil Im, Marcos M. Pires
      Abstract: Feigman et al. describe a mode of re-engaging components of the immune system to target Gram-negative bacteria for destruction. By modifying polymyxin B to include antibody recruiting epitopes, bacterial cell surfaces were decorated with agents that triggered antibody binding and cell killing.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-07-05
      DOI: 10.1016/j.chembiol.2018.05.019
  • Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus
           influenzae Abrogates Serum Resistance
    • Authors: Torben Heise; Jeroen D. Langereis, Emiel Rossing, Marien I. de Jonge, Gosse J. Adema, Christian Büll, Thomas J. Boltje
      Abstract: Molecular mimicry of non-typeable Haemophilus influenzae (NTHi) with host sialic acid sugars mediates resistance to serum killing and increases virulence. Heise et al. have developed sialic acid derivatives that allow either visualization or inhibition of host sialic acid transfer to NTHi, the latter enhancing serum-mediated killing.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-07-05
      DOI: 10.1016/j.chembiol.2018.05.018
  • A Quantitative Chemoproteomic Platform to Monitor Selenocysteine
           Reactivity within a Complex Proteome
    • Authors: Daniel W. Bak; Jinjun Gao, Chu Wang, Eranthie Weerapana
      Abstract: Bak et al. describe a chemoproteomic method for the global enrichment and identification of selenocysteine (Sec) residues. Low-pH iodoacetamide-alkyne labeling masks Cys reactivity, allowing for tissue-specific selenoprotein identification. This platform shows promise for interrogating the specificity of Sec inhibitors, such as auranofin.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-07-05
      DOI: 10.1016/j.chembiol.2018.05.017
  • Combined Proteomic and In Silico Target Identification Reveal a Role for
           5-Lipoxygenase in Developmental Signaling Pathways
    • Authors: Silke Brand; Sayantani Roy, Peter Schröder, Bernd Rathmer, Jessica Roos, Shobhna Kapoor, Sumersing Patil, Claudia Pommerenke, Thorsten Maier, Petra Janning, Sonja Eberth, Dieter Steinhilber, Dennis Schade, Gisbert Schneider, Kamal Kumar, Slava Ziegler, Herbert Waldmann
      Abstract: Using cell-based screening, Brand et al. identified 3,5-substituted-2,4-dimethoxypyridines as inhibitors of Wnt signaling. Combination of chemical proteomics and computational target prediction followed by target validation revealed 5-lipoxygenase as the target.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.chembiol.2018.05.016
  • Approved Anti-cancer Drugs Target Oncogenic Non-coding RNAs
    • Authors: Sai Pradeep Velagapudi; Matthew G. Costales, Balayeshwanth R. Vummidi, Yoshio Nakai, Alicia J. Angelbello, Tuan Tran, Hafeez S. Haniff, Yasumasa Matsumoto, Zi Fu Wang, Arnab K. Chatterjee, Jessica L. Childs-Disney, Matthew D. Disney
      Abstract: RNA is an emerging target for small molecules, but has it been an established one all along' Velagapudi et al. profiled the binding of medicines to thousands of RNA motifs, showing that broad drug classes bind RNA. Indeed, approved anti-cancer drugs target an oncogenic non-coding RNA, affecting its phenotype.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.chembiol.2018.05.015
  • Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease
           Activity and Cause Apoptotic Cell Death
    • Authors: Keith S. Wong; Mark F. Mabanglo, Thiago V. Seraphim, Antonio Mollica, Yu-Qian Mao, Kamran Rizzolo, Elisa Leung, Mohamed T. Moutaoufik, Larissa Hoell, Sadhna Phanse, Jordan Goodreid, Leandro R.S. Barbosa, Carlos H.I. Ramos, Mohan Babu, Vito Mennella, Robert A. Batey, Aaron D. Schimmer, Walid A. Houry
      Abstract: Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved bacterial ClpP protease. We identified ADEP analogs that are potent dysregulators of the human mitochondrial ClpP (HsClpP). The compounds were found to cause apoptotic cell death. The ADEP-HsClpP co-crystal structure revealed, unexpectedly, HsClpP in the compact conformation.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.chembiol.2018.05.014
  • Genetically Encoded Protein Phosphorylation in Mammalian Cells
    • Authors: Václav Beránek; Christopher D. Reinkemeier, Michael S. Zhang, Alexandria D. Liang, Gene Kym, Jason W. Chin
      Abstract: Beránek et al. describe an aminoacyl-tRNA synthetase/tRNA pair that is orthogonal in mammalian cells. They demonstrate that this pair can be used to incorporate phosphoserine and a stable phosphonate analog. By encoding the phosphonate analog in a kinase activation loop, they synthetically activate the kinase.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.chembiol.2018.05.013
  • Resistance to Enediyne Antitumor Antibiotics by Sequestration
    • Authors: Chin-Yuan Chang; Xiaohui Yan, Ivana Crnovcic, Thibault Annaval, Changsoo Chang, Boguslaw Nocek, Jeffrey D. Rudolf, Dong Yang, Hindra, Gyorgy Babnigg, Andrzej Joachimiak, George N. Phillips, Ben Shen
      Abstract: TnmS1, TnmS2, and TnmS3 confer tiancimycin resistance by sequestration. Their homologs are found in all anthraquinone-fused enediyne producers and are widespread in nature, including in the human microbiome. These findings unveil an unprecedented resistance mechanism for the enediynes and should be considered in future efforts to develop enediyne-based chemotherapies.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.chembiol.2018.05.012
  • Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral
           Envelope Protein
    • Authors: Melissanne de Wispelaere; Wenlong Lian, Supanee Potisopon, Pi-Chun Li, Jaebong Jang, Scott B. Ficarro, Margaret J. Clark, Xuling Zhu, Jenifer B. Kaplan, Jared D. Pitts, Thomas E. Wales, Jinhua Wang, John R. Engen, Jarrod A. Marto, Nathanael S. Gray, Priscilla L. Yang
      Abstract: Countermeasures against dengue, Zika, and other flaviviruses are a large, unmet medical need. de Wispelaere et al. validate a conserved pocket of the flavivirus envelope protein as a target for small-molecule antivirals with broad-spectrum activity against flaviviruses.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-21
      DOI: 10.1016/j.chembiol.2018.05.011
  • A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing
           Acute Mutagenesis Frequency
    • Authors: Michael D. Birnbaum; Leah Nemzow, Akhilesh Kumar, Feng Gong, Fangliang Zhang
      Abstract: The mutation-activated CherryOFF-GFP reporter quickly and accurately reflects point mutation frequency via flow cytometry readout. This reporter can easily be adapted for different point mutations and indels.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.chembiol.2018.05.010
  • Programming Cell-Cell Interactions through Non-genetic Membrane
    • Authors: Clifford M. Csizmar; Jacob R. Petersburg, Carston R. Wagner
      Abstract: Non-genetic techniques for modifying cell membranes with artificial targeting ligands have emerged as powerful and flexible tools for controlling cellular interactions. Csizmar et al. review the current techniques and applications for this expanding field, and provide perspective on key features that may enhance the clinical translatability of these systems.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.chembiol.2018.05.009
  • Overcoming Resistance to Targeted Anticancer Therapies through
           Small-Molecule-Mediated MEK Degradation
    • Authors: Jessie Peh; Matthew W. Boudreau, Hannah M. Smith, Paul J. Hergenrother
      Abstract: Rapid onset of resistance to targeted kinase inhibitors limits their use in treating advanced cancers. Peh et al. show that combination of diverse kinase inhibitors with a procaspase-3 activating compound (PAC-1) leads to degradation of MEK1/2, dramatically delaying acquired resistance.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.chembiol.2018.05.008
  • Inhibition of Bacterial Gene Transcription with an RpoN-Based Stapled
    • Authors: Sterling R. Payne; Daniel I. Pau, Amanda L. Whiting, Ye Joon Kim, Blaze M. Pharoah, Christina Moi, Christopher N. Boddy, Federico Bernal
      Abstract: The bacterial transcriptional regulator σ54 is involved in the virulence of pathogenic bacteria. Stapled peptides blocking the interaction between σ54 and its target DNA promoter inhibit activation of σ54-dependent genes in bacteria. These compounds provide an avenue to target bacterial pathogens and circumvent therapeutic drug resistance.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.chembiol.2018.05.007
  • Protein Acylation is a General Regulatory Mechanism in Biosynthetic
           Pathway of Acyl-CoA-Derived Natural Products
    • Authors: Jun-Yu Xu; Ya Xu, Zhen Xu, Lin-Hui Zhai, Yang Ye, Yingming Zhao, Xiaohe Chu, Minjia Tan, Bang-Ce Ye
      Abstract: Xu et al. systematically investigated the general interplay between beneficial and adverse effects of cellular acyl-CoA concentrations on the biosynthesis of acyl-CoA-derived natural products in bacteria, which provided insight into the potential function of the identified lysine acylation substrates.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.chembiol.2018.05.005
  • A Proposed Mechanism for Neurodegeneration in Movement Disorders
           Characterized by Metal Dyshomeostasis and Oxidative Stress
    • Authors: Benjamin Guy Trist; Dominic James Hare, Kay Lorraine Double
      Abstract: Trist et al. propose a shared etiological pathway in Parkinson disease and SOD1-associated familial amyotrophic lateral sclerosis, whereby concomitant changes in cellular copper and oxidative stress within dying neurons contribute to the dysfunction of specific proteins that are essential for maintaining neuronal health, including superoxide dismutase 1.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.004
  • Protein Lipidation in Cell Signaling and Diseases: Function, Regulation,
           and Therapeutic Opportunities
    • Authors: Baoen Chen; Yang Sun, Jixiao Niu, Gopala K. Jarugumilli, Xu Wu
      Abstract: We highlight recent progress in our understanding of protein lipidation, in particular, S-palmitoylation, and describe the importance of protein lipidation in cell signaling and diseases. We further highlight opportunities and new strategies for targeting protein lipidation for therapeutic applications.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.003
  • Redefining the Protein Kinase Conformational Space with Machine Learning
    • Authors: Peter Man-Un Ung; Rayees Rahman, Avner Schlessinger
      Abstract: Ung and Rahman et al. constructed a machine-learning-based algorithm to refine the current classification of protein kinase structures into active and inactive conformations. Analysis of the small molecules recognized by each conformation captures conformation-specific chemical substructures.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.chembiol.2018.05.002
  • Convergent Use of Heptacoordination for Cation Selectivity by RNA and
           Protein Metalloregulators
    • Authors: Sharrol T. Bachas; Adrian R. Ferré-D'Amaré
      Abstract: Bachas and Ferré-D'Amaré demonstrate how the broad family of yybP-ykoY riboswitches use heptacoordination to selectively bind transition metal ions. Heptacoordination is further generalized as a convergent selectivity mechanism used by protein and RNA metalloregulators that sense similar transition metals.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.016
  • Addressable Cholesterol Analogs for Live Imaging of Cellular Membranes
    • Authors: Lena Rakers; David Grill, Anna L.L. Matos, Stephanie Wulff, Da Wang, Jonas Börgel, Martin Körsgen, Heinrich F. Arlinghaus, Hans-Joachim Galla, Volker Gerke, Frank Glorius
      Abstract: Cholesterol is an important component of biological membranes, but probes recording its dynamic intracellular distribution are scarce. Rakers et al. developed cholesterol-derived imidazolium salts mimicking properties of natural cholesterol. Following specific labeling via click chemistry, one of the cholesterol analogs was shown to incorporate into cellular membranes equivalent to endogenous cholesterol.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.015
  • Structure-based Engineering of a Plant-Fungal Hybrid Peroxidase for
           Enhanced Temperature and pH Tolerance
    • Authors: Amanda C. Kohler; Blake A. Simmons, Kenneth L. Sale
      Abstract: Kohler et al. describe a rational engineering approach for the direct design of innovative, industrially tailored biocatalysts. They utilize this approach to address the current application barrier of high-reduction potential peroxidases as oxidative tools, building a catalytically versatile plant-fungal hybrid peroxidase capable of functioning under wider temperature and pH ranges.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.014
  • Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of
           Sulfonylfluoride Peptidomimetics
    • Authors: Salvador Guardiola; Roger Prades, Laura Mendieta, Arwin J. Brouwer, Jelle Streefkerk, Laura Nevola, Teresa Tarragó, Rob M.J. Liskamp, Ernest Giralt
      Abstract: Prolyl oligopeptidase (POP) is a neuronal enzyme involved in cognitive disorders. By combining a peptidomimetic scaffold with a mild electrophile, Guardiola et al. designed highly active covalent inhibitors that are not only potent and selective but display optimal properties for accessing the brain by passive diffusion.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.013
  • Construction of Fluorescent Analogs to Follow the Uptake and Distribution
           of Cobalamin (Vitamin B12) in Bacteria, Worms, and Plants
    • Authors: Andrew D. Lawrence; Emi Nemoto-Smith, Evelyne Deery, Joseph A. Baker, Susanne Schroeder, David G. Brown, Jennifer M.A. Tullet, Mark J. Howard, Ian R. Brown, Alison G. Smith, Helena I. Boshoff, Clifton E. Barry, Martin J. Warren
      Abstract: Lawrence et al., employed chemical biology approaches to construct a range of fluorescent vitamin B12 derivatives. They demonstrated that these fluorescent variants can be used to follow intracellular B12 trafficking in bacteria, including E. coli and M. tuberculosis, the worm C. elegans, and a higher plant (Lepidium sativum).
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.012
  • De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry
    • Authors: Toby Passioura; Koichi Watashi, Kento Fukano, Satomi Shimura, Wakana Saso, Ryo Morishita, Yuki Ogasawara, Yasuhito Tanaka, Masashi Mizokami, Camille Sureau, Hiroaki Suga, Takaji Wakita
      Abstract: Hepatitis B virus infection causes serious illness and current treatments are not curative. In this work, Passioura et al. describe diverse small macrocyclic peptides that bind to the cellular receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP), and block viral entry without affecting NTCP's taurocholate transporting activity.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.011
  • Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues
           F508del-CFTR in Cystic Fibrosis Airway Epithelia
    • Authors: Elvira Sondo; Federico Falchi, Emanuela Caci, Loretta Ferrera, Elisa Giacomini, Emanuela Pesce, Valeria Tomati, Sine Mandrup Bertozzi, Luca Goldoni, Andrea Armirotti, Roberto Ravazzolo, Andrea Cavalli, Nicoletta Pedemonte
      Abstract: Sondo et al. used a computational approach to identify an inhibitor, named inh-02, for RNF5 ubiquitin ligase. RNF5 detects the misfolding of a mutant CFTR in cystic fibrosis. Inh-2 decreases ubiquitylation and rescues F508del-CFTR on human primary bronchial epithelia. This work validates RNF5 as a drug target for cystic fibrosis.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.010
  • Structural Insights into Subunits Assembly and the Oxyester Splicing
           Mechanism of Neq pol Split Intein
    • Authors: Verónica Gordo; David Aparicio, Rosa Pérez-Luque, Antoni Benito, Maria Vilanova, Isabel Usón, Ignacio Fita, Marc Ribó
      Abstract: Gordo et al. have determined the crystal structures of both the isolated NeqN subunit and the NeqN/NeqC complex. In these structures, Neq pol subunits carry the intein wild-type sequences, including the essential catalytic residues Ser1 and Thr+1, together with several residues from the N- and C-exteins.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.008
  • Measuring Endoplasmic Reticulum Signal Sequences Translocation Efficiency
           Using the Xbp1 Arrest Peptide
    • Authors: Theresa Kriegler; Anastasia Magoulopoulou, Rocio Amate Marchal, Tara Hessa
      Abstract: Kriegler et al. measured functional efficiency of ER signal sequences by using stalled ribosome-nascent chains derived from the Xbp1 arrest peptide. Efficiencies are measured as “pulling forces”, whereby an efficient signal sequence generates two pulling events while an inefficient signal sequence experiences a single one, reflecting its incomplete engagement.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.chembiol.2018.04.006
  • Combining Promiscuous Acyl-CoA Oxidase and Enoyl-CoA
    • Authors: Bastian Vögeli; Kyra Geyer, Patrick D. Gerlinger, Sarah Benkstein, Niña Socorro Cortina, Tobias J. Erb
      Abstract: Vögeli et al. present a chemo-biosynthetic strategy that employs biocatalytic proofreading and allows production of a large variety of alkylmalonyl-CoA extender units by utilizing a promiscuous acyl-CoA oxidase and an engineered promiscuous enoyl-CoA carboxylase/reductase. The extender units are used to test the substrate specificity of the polyketide synthase DEBS.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.009
  • Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase
    • Authors: Carlos Moreno-Yruela; Iacopo Galleano, Andreas S. Madsen, Christian A. Olsen
      Abstract: Moreno-Yruela et al. show that histone deacetylase 11 (HDAC11) cleaves long-chain acyl modifications on lysine side chains with remarkable efficiency, and macrocyclic hydroxamic acid-containing peptides potently inhibit HDAC11 demyristoylation. These findings provide a foundation for future development of selective chemical probes targeting HDAC11.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.007
  • Mechanism of Allosteric Coupling into and through the Plasma Membrane by
    • Authors: Julie K.L. Sinclair; Allison S. Walker, Amy E. Doerner, Alanna Schepartz
      Abstract: The mechanism by which EGFR communicates growth factor-dependent signals to the cell interior is unknown. Here we show that growth factor identity is encoded into discrete TM helix dimers. These dimers induce different coiled-coil structures within the JM region that correlate with downstream signaling.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.chembiol.2018.04.005
  • Structural Lipids Enable the Formation of Functional Oligomers of the
           Eukaryotic Purine Symporter UapA
    • Authors: Euan Pyle; Antreas C. Kalli, Sotiris Amillis, Zoe Hall, Andy M. Lau, Aylin C. Hanyaloglu, George Diallinas, Bernadette Byrne, Argyris Politis
      Abstract: We describe the first in-depth analysis of membrane lipid interactions with a eukaryotic transporter using native mass spectrometry. We demonstrate that the binding of structural lipids is essential to maintain the stability of the functional UapA dimer in both the gas phase and in vivo.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.011
  • Cellular Cyborgs: On the Precipice of a Drug Delivery Revolution
    • Authors: Song Ding; Colin P. O'Banion, Joshua G. Welfare, David S. Lawrence
      First page: 648
      Abstract: Cells have been used to restrain, convey, and release therapeutic agents. This review highlights the strategies associated with the design and implantation of cell-based drug delivery platforms.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.003
  • Bacterial Alkaloid Biosynthesis: Structural Diversity via a Minimalistic
           Nonribosomal Peptide Synthetase
    • Authors: Martin Klapper; Daniel Braga, Gerald Lackner, Rosa Herbst, Pierre Stallforth
      First page: 659
      Abstract: Nonribosomal peptides are a diverse class of ecologically and clinically relevant natural products. Here, Klapper et al. study one of the simplest bacterial nonribosomal peptide synthetases of different Pseudomonas strains. A single gene, encoding the monomodular pyreudione synthetase, leads to the production of a variety of bioactive alkaloids.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.chembiol.2018.02.013
  • Structural Insights into the Forward and Reverse Enzymatic Reactions in
           Human Adenine Phosphoribosyltransferase
    • Authors: Jessica Huyet; Mohammad Ozeir, Marie-Claude Burgevin, Benoît Pinson, Françoise Chesney, Jean-Marc Remy, Abdul Rauf Siddiqi, Roland Lupoli, Gregory Pinon, Christelle Saint-Marc, Jean-Francois Gibert, Renaud Morales, Irène Ceballos-Picot, Robert Barouki, Bertrand Daignan-Fornier, Anne Olivier-Bandini, Franck Augé, Pierre Nioche
      First page: 666
      Abstract: APRT is a key enzyme in the purine salvage pathway in prokaryotes and eukaryotes. Huyet et al., by using in vitro, cellular, and in crystallo enzymatic analyses, reveal that a hydroxyl group in a conserved tyrosine controls the protein dynamics and the catalytic efficiencies of the forward and reverse reactions.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-22
      DOI: 10.1016/j.chembiol.2018.02.011
  • Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain
           to Interrupt BRCA1-Dependent Signaling
    • Authors: Jayaprakash Periasamy; Vadiraj Kurdekar, Subbarao Jasti, Mamatha B. Nijaguna, Sanjana Boggaram, Manjunath A. Hurakadli, Dhruv Raina, Lokavya Meenakshi Kurup, Chetan Chintha, Kavyashree Manjunath, Aneesh Goyal, Gayathri Sadasivam, Kavitha Bharatham, Muralidhara Padigaru, Vijay Potluri, Ashok R. Venkitaraman
      First page: 677
      Abstract: Periasamy et al. report the development of Bractoppin, a drug-like inhibitor of phosphopeptide recognition by the BRCA1 tBRCT domain, opening avenues to block intracellular signaling via a family of related targets.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.chembiol.2018.02.012
  • The Rheumatoid Arthritis-Associated Citrullinome
    • Authors: Ronak Tilvawala; Son Hong Nguyen, Aaron J. Maurais, Venkatesh V. Nemmara, Mitesh Nagar, Ari J. Salinger, Sunil Nagpal, Eranthie Weerapana, Paul R. Thompson
      First page: 691
      Abstract: Tilvawala et al. demonstrated that protein citrullination is elevated in RA and defined the RA-associated citrullinome. Tilvawala et al. further discovered that Serpin citrullination abolishes their ability to inhibit their cognate proteases. These studies open a new avenue to understand the links between protein citrullination and numerous diseases.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.002
  • Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic
           Lethal Vulnerability in Mutant KRAS-Driven Cancers
    • Authors: Malvika Koundinya; Judith Sudhalter, Albane Courjaud, Bruno Lionne, Gaetan Touyer, Luc Bonnet, Isabelle Menguy, Isabelle Schreiber, Christelle Perrault, Stephanie Vougier, Brigitte Benhamou, Bailin Zhang, Timothy He, Qiang Gao, Patricia Gee, Daniel Simard, M. Paola Castaldi, Ronald Tomlinson, Stephan Reiling, Matthieu Barrague, Richard Newcombe, Hui Cao, Yanjun Wang, Fangxian Sun, Joshua Murtie, Mark Munson, Eric Yang, David Harper, Monsif Bouaboula, Jack Pollard, Claudine Grepin, Carlos Garcia-Echeverria, Hong Cheng, Francisco Adrian, Christopher Winter, Stuart Licht, Ivan Cornella-Taracido, Rosalia Arrebola, Aaron Morris
      First page: 705
      Abstract: Koundinya et al. show that inhibitors of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase selectively inhibit the growth of KRAS mutant cell lines. Differential sensitivity of the mutant lines correlates with differential effects of the inhibitors on primary energy metabolism and glutamine levels, and the inhibitors synergize with some clinically used anticancer agents.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.chembiol.2018.03.005
  • Structural Insights into a Flavin-Dependent [4 + 2] Cyclase that
           Catalyzes trans-Decalin Formation in Pyrroindomycin Biosynthesis
    • Authors: Qingfei Zheng; Yukang Gong, Yujiao Guo, Zhixiong Zhao, Zhuhua Wu, Zixuan Zhou, Dandan Chen, Lifeng Pan, Wen Liu
      First page: 718
      Abstract: Zheng et al. provide structural and mechanistic insights into PyrE3, a flavin-dependent cyclase that does not require flavin redox change during the process of catalyzing an endo-selective Diels-Alder-like [4 + 2] cycloaddition, thereby generating interest regarding the versatile functions of flavoenzymes that have not been fully appreciated.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.chembiol.2018.03.007
  • Structural Determinants for Small-Molecule Activation of Skeletal Muscle
           AMPK α2β2γ1 by the Glucose Importagog SC4
    • Authors: Kevin R.W. Ngoei; Christopher G. Langendorf, Naomi X.Y. Ling, Ashfaqul Hoque, Swapna Varghese, Michelle A. Camerino, Scott R. Walker, Ylva E. Bozikis, Toby A. Dite, Ashley J. Ovens, William J. Smiles, Roxane Jacobs, He Huang, Michael W. Parker, John W. Scott, Mark H. Rider, Richard C. Foitzik, Bruce E. Kemp, Jonathan B. Baell, Jonathan S. Oakhill
      First page: 728
      Abstract: Therapeutic activation of the metabolic regulator AMPK in skeletal muscle is a validated strategy to combat type 2 diabetes. Ngoei et al. have solved the crystal structure of the activator SC4 complexed to a skeletal muscle AMPK isoform, identifying important binding determinants that will advance development of AMPK-targeting therapeutics.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.chembiol.2018.03.008
  • Mitochondria Export Sulfur Species Required for Cytosolic tRNA Thiolation
    • Authors: Alok Pandey; Jayashree Pain, Nathaniel Dziuba, Ashutosh K. Pandey, Andrew Dancis, Paul A. Lindahl, Debkumar Pain
      First page: 738
      Abstract: Critical signals and metabolites move between mitochondria and cytosol, and such communications are essential for cellular homeostasis. Pandey et al. demonstrate that mitochondria generate activated sulfur intermediates (Sint). The intermediates are exported to the cytosol in an ATP-dependent fashion, and there they are utilized for thio-modification of tRNAs.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.chembiol.2018.04.002
  • PDn-3 DPA Pathway Regulates Human Monocyte Differentiation and Macrophage
    • Authors: Kimberly Pistorius; Patricia R. Souza, Roberta De Matteis, Shani Austin-Williams, Karoline G. Primdahl, Anders Vik, Francesca Mazzacuva, Romain A. Colas, Raquel M. Marques, Trond V. Hansen, Jesmond Dalli
      First page: 749
      Abstract: Pistorius et al., found that a recently uncovered family of bioactive mediators termed PDn-3 DPA controls human macrophage phenotype and function during their differentiation from monocytes. The authors also established the biosynthetic pathway for this family of mediators thereby providing leads into mechanisms that control macrophage responses.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.chembiol.2018.04.017
  • A Designed Peptide Targets Two Types of Modifications of p53 with
           Anti-cancer Activity
    • Authors: Lunxi Liang; Huanbin Wang, Hubing Shi, Zhaoli Li, Han Yao, Zhigao Bu, Ningning Song, Chushu Li, Dabin Xiang, Yao Zhang, Jilin Wang, Ye Hu, Qi Xu, Yanlei Ma, Zhongyi Cheng, Yingchao Wang, Shuliang Zhao, Jin Qian, Yingxuan Chen, Jing-Yuan Fang, Jie Xu
      First page: 761
      Abstract: Liang et al. describe a designed peptide that regulates two types of post-translational modifications of p53 with anti-cancer effect, based on the identification of a Morn3-mediated protein complex that confers composite modifications on p53. The findings highlight a strategy for targeting composite protein modifications with one molecule.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.010
  • Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human
           Oligodendrocyte Differentiation
    • Authors: Nicole Merten; Julia Fischer, Katharina Simon, Liguo Zhang, Ralf Schröder, Lucas Peters, Anne-Gaelle Letombe, Stephanie Hennen, Ramona Schrage, Theresa Bödefeld, Celine Vermeiren, Michel Gillard, Klaus Mohr, Qing Richard Lu, Oliver Brüstle, Jesus Gomeza, Evi Kostenis
      First page: 775
      Abstract: Identification of alternative uses for existing drugs is a hot topic in drug discovery. Merten et al. repurposed the experimental drug HAMI3379, originally developed to treat cardiovascular and inflammatory disorders, for pharmacological exploitation of orphan GPR17, and thereby enhance regenerative strategies for promotion of remyelination in patients.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.chembiol.2018.03.012
  • Linking Genomic and Metabolomic Natural Variation Uncovers Nematode
           Pheromone Biosynthesis
    • Authors: Jan M. Falcke; Neelanjan Bose, Alexander B. Artyukhin, Christian Rödelsperger, Gabriel V. Markov, Joshua J. Yim, Dominik Grimm, Marc H. Claassen, Oishika Panda, Joshua A. Baccile, Ying K. Zhang, Henry H. Le, Dino Jolic, Frank C. Schroeder, Ralf J. Sommer
      First page: 787
      Abstract: A small-molecule library, the ascarosides, regulates the life history of Caenorhabditis elegans and Pristionchus pacificus. GWAS combined with metabolomics of P. pacificus natural isolates revealed a putative carboxylesterase, Ppa-uar-1, involved in attaching a pyrimidine-derived moiety in the biosynthesis of a major dauer pheromone component.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.chembiol.2018.04.004
  • Site-Specific Three-Color Labeling of α-Synuclein via Conjugation to
           Uniquely Reactive Cysteines during Assembly by Native Chemical Ligation
    • Authors: Taehyung C. Lee; Crystal R. Moran, Philip A. Cistrone, Philip E. Dawson, Ashok A. Deniz
      First page: 797
      Abstract: Lee and Moran et al. present a strategy for fully site-specific labeling of the intrinsically disordered protein α-synuclein with three fluorophores for multi-color single-molecule FRET. This expandable method uses standard maleimide-cysteine chemistry, and enables more global investigation of complex proteins and their dynamic interactions.
      Citation: Cell Chemical Biology (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.chembiol.2018.03.009
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