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Journal Cover Jurnal Kefarmasian Indonesia
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2085-675X - ISSN (Online) 2354-8770
   Published by Badan Penelitian dan Pengembangan Kesehatan Homepage  [6 journals]
  • Front Matter Jurnal Kefarmasian Indonesia Volume 7 Nomor 2 Agustus 2017

    • Authors: Editor JKI
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Efek Kapsul Ekstrak Etanol Kulit Buah Delima (Punica granatum L.) terhadap
           Penanda Pembentukan dan Kualitas Tulang pada Wanita Pascamenopause

    • Authors: Nur Hayati Dwi Handayani, Anton Bahtiar, Melva Louisa
      Abstract: Studies of pomegranate peel (Punica granatum L.), which contain ellagic acid, suggest its ability to increase osteoblast, calcium, and phosphorus in ovariectomized rats. The effects of the pomegranate peel extracts on postmenopausal women was not known. This study was aimed to evaluate the effect of pomegranate peel ethanol extract capsules in the modulation of bone formation and bone quality markers in postmenopausal women. This study is a pilot study of 1st phase of clinical trial using parallel, randomized, double-blind, and placebo controlled design, with 30 subjects. Subjects were randomized to receive commercial capsules of pomegranate peel ethanol extract 2 × 1100 mg/ day or placebo, for 8 weeks. Levels of osteocalcin, calcium, and phosphorus were examined before and after treatment. This study showed that administration of the capsules in postmenopausal women tends to reduce blood osteocalcin level (4,129±5,66 ng/mL on placebo group versus 1,79±5,04 ng/mL on punica group, p=0,245), has not significant on blood calcium level (9,13±0,36 mg/dL placebo group versus 9,21±0,39 mg/dL punica group, p=0,379), has not significant on blood phosphorus level (3,93±0,38 mg/dL placebo group versus 4,12±0,41 mg/dL on punica group, p=0,138), does not affect the function of liver and kidney, and was well tolerated. In conclusion, the commercial capsules is safe, potentially reduce marker of bone formation serum level,and  increase bone quality on postmenopausal women.  
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Aktivitas Ramuan Daun Salam, Herba Pegagan, Akar Alang-Alang dan Biji Pala
           pada Tikus Hipertensi yang Diinduksi Prednison dan Garam

    • Authors: Ulfatun Nisa, Ulfa Fitriani, Enggar Wijayanti
      Abstract: The prevalence of hypertension in Indonesia was 25,8%. As much as 70% types of hypertensive patients were mild hypertension. There were some medicinal plants contain single formulation could be used for lowering blood pressure but not in a herbal formulation. This study determined the efficacy of antihypertension herbal formulation that consists of Indonesian bay leaves, Centella herbs, blady grass roots dan nutmeg seeds. This study was an experimental laboratory research with pre and post-test controlled design, used thirty Sprague-Dawley rats that were classified randomly into five groups (negative control group which didn't have treatment, positive control group which consumed captopril 0,25 mg, and three groups which consumed antihypertension herbal formulation with doses of 0,08 g; 0,16 g; and 0,32 g. The rats were induced by prednisone and NaCl 2,5 % for 21 days.  The data were analysed using ANOVA test with CI 95%. After two weeks observation, the results showed that the blood pressure in the negative control group increased,  but in the positive control and treatment groups decreased significantly (p=0,001). In conclusion, the herbal formulation could decrease rat's blood pressure.  
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Identification of HMG-CoA Reductase Inhibitor Active Compound in Medicinal
           Forest Plants

    • Authors: Shelly Rahmania, Sulistiyani Sulistiyani, Arthur A Lelono
      Abstract: Cardiovascular disease is a leading cause of death worldwide, hypercholesterolemia is one of the causes. Three medicinal forest plants are potential natural resources to be developed as cholesterol-reducing herbal product, but scientific informations on their mechanism is still limited. The objective of this research is to explore the potency of the leaf of Jati Belanda (Guazuma ulmifolia), Jabon (Antocephalus macrophyllus), and Mindi (Melia azedarach) as inhibitor of HMG-CoA reductase (HMGR), a key enzyme in the regulation of cholesterol biosynthesis. Samples were macerated in ethanol 96% and the filtrate was partitioned using n-hexane and chloroform to obtain the ethanolic flavonoid extract. The effect of each extracts on the HMG-CoA reductase activity were analyzed using HMGR assay kit. At concentration of 10 ppm the G.ulmifolia ethanolic extract showed the highest inhibitory activity as well as pravastatin control inhibitor.  The phenolic content of the ethanolic extracts of G.ulmifolia, A.macrophyllus, and M.azedarach were: 11.00, 34.83, and 13.67 mg gallic acid AE/g dried leaves, respectively. The flavonoid content of the ethanolic extracts of G.ulmifolia, A.macrophyllus, and M.azedarach were: 0.22, 0.64, and 0.78 mg QE/g dried leaves, respectively. Interestingly, G.ulmifolia extract the lowest concentration of phenolic and flavonoid content. HPLC analysis showed that all samples contain quercetin at similiar small concentrations (6.7%, 6.6%, and 7.0% for G.ulmifolia, A.macrophyllus, and M.azedarach, respectively). This indicating other active compounds may play some roles in this inhibitory action on HMG-CoA reductase activity. Further identification using LC-MS/MS showed that G.ulmifolia flavonoid extract contained an unidetified coumpound with molecural weight of 380.0723 Da.  
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Isolasi, Identifikasi, Karakterisasi, dan Uji Antibiofilm Derivat Asam
           Galat dari Kulit Batang Sterculia quadrifida R.Br

    • Authors: Rollando Rollando
      Abstract: Faloak (Sterculia quadrifida R.Br) is used empirically by residents of Timor island to treat hepatitis, typhoid, ulcers, and to restore stamina. Information of active compound contained in the bark of faloak specifically unpublished. This study aims to determine the active compound contained in faloak bark that can be used as antibiofilm. The extraction was performed by soxletation method, the isolation was performed by gradient isolation method, the elusidation was performed by merging information from NMR and LC-MS spectra analysis. The biofilm inhibition activity test was performed by microdilution method formed on flat bottom flexible microplate U-bottom PVC 96 wells with staining using 1% crystal violet. The isolation process obtained 3 gallic acid derivatives, named isolate 1, isolate 2, and isolate 3. Test of inhibition of biofilm formation showed isolate 1 has IC50 of 46,87 µg/mL, isolate 2 has IC50 of 45,87 µg/mL, and isolate 3 has IC50 42,65 µg/mL.The biofilm test results showed that isolates 1-3 had high biofilm inhibition potency.
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Uji Bioavailabilitas Tablet Floating Aspirin

    • Authors: Agus Siswanto, Achmad Fudholi, Akhmad Kharis Nugroho, Sudibyo Martono
      Abstract: Aspirin is a non-steroidal anti-inflammatory drug with potential as antiplatelet for stroke prophylaxis. Several approaches of aspirin formulations in various dosage forms have been performed. Formulations of aspirin in conventional tablet dosage form often cause gastric irritation. Aspirin is rapidly absorbed in the upper gastrointestinal tract, especially the first small intestine. Therefore formulation of floating drug delivery system are designed to improve the bioavailability of aspirin. The floating system will retain the tablet in stomach, allowing sufficient absorption time for aspirin in stomach and upper intestine. Aim of this study was to determine relative bioavailability of aspirin floating tablets compared to the aspirin enteric coated tablets in rabbits with crossover design method. Serial blood samples were collected from rabbit ear marginal vein over a 10-h period. Drugs concentration in plasma (aspirin and salisylic acid) were determined by HPLC with benzoic acid as internal standard. The results showed that the floating aspirin tablet has better bioavailability with shorter tmax and more uniform of aspirin levels compared to enteric coated tablets, though the parameters AUC and Cpmax both of those products were not significant (p> 0.05).
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Pemanfaatan Minyak Kayu Putih (Melaleuca leucadendra Linn) sebagai

    • Authors: Zulfa Auliyati Agustina, Suharmiati Suharmiati
      Abstract: The Acute Respiratory Infections (ARIs) is a disease which commonly infects children. Based on Indonesian basic health research 2013, the national and Buru Island's period prevalence of ARIs were 25% and 24,8%. The other side, cajuput oil has been traditionally used to reduce respiratory tract disorders and infections. This research used the ethnographic approach with observation participation and direct communication to collected the data. The results showed a high number in ARIs cases in Buru Island area were affected by many factors, some of them are the lack of Clean and Healthy Behaviour (PHBS) and had a little faith in health services, especially for people who live in the mountain area. It was because of minimum intervention from public health services. This research showed the Cajuput oil was potentially used as an alternative prevention of ARIs in Buru Island by inhalation method. The main content of Melaleuca leucadendra Linn had a benefit to be the mucolytics, bronchodilator, anti-inflammation and antitussive. 
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Uji Aktivitas Antibakteri Ekstrak Etanol Tanaman Obat Suku Musi di
           Kabupaten Musi Banyuasin, Sumatera Selatan

    • Authors: Muharni Maryadi, Fitrya Yusuf, Sofa Farida
      Abstract: Musi tribe community used medicinal plants generally based on cultural heritage. Unproper use of medicinal plants unproperly cause the drug does not work effectively. Ten medicinal plants were selected for antibacterial activity tested using disc diffusion method against two testb bacteria i.e Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) at concentrations of 125, 250, 500, and 1000 μg/mL. Minimum inhibitory concentration (MIC) were determined for the active extract which still gives antibacterial activity using well method. The result showed only three test extracts, i.e Coleus scutellarioides, Blumea balsamifera and Lantana camara gave inhibition zone diameter of 11-20 mm against E. coli. Meanwhile, four extracts i.e Coleus scutellarioides, Blumea balsamifera, Dillenia alata and Dimocarpus melayensis gave inhibition zone diameter ​​of 11-20 mm against S. aureus. Determination of MIC values ​​for Coleus scutellarioides and Blumea balsamifera extracts gave the same MIC value of 125 μg/mL for both test bacteria. Meanwhile, Lantana camara gave MIC value of 250 ug/mL for E. coli. Dillenia alata and Dimocarpus melayensis also provide MIC value of 125 ug/mL againts E. Coli. It was found that there were five active extracts among ten extracts tested. Two extracts which active against both test bacteria were Coleus scutellarioides and Blumea balsamifera. One extract, Lantana camara only active against E. coli and the two others Dillenia alata and Dimocarpus melayensis were active against S. auerus.
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Pengetahuan, Sikap, dan Perilaku Masyarakat dalam Memilih Obat yang Aman
           di Tiga Provinsi di Indonesia

    • Authors: Selma Arsit Selto Siahaan, Tepi Usia, Sri Pujiati, Ingan Ukur Tarigan, Sri Murhandini, Siti Isfandari, Tiurdinawati Tiurdinawati
      Abstract: Medicine is an important component that cannot be replaced in health service. Indonesia National Agency of Drug and Food Control conducted survey to assess knowledge, attitude, and practice (KAP) of communities on selecting safe and quality medicines. The aim of the study is to get description KAP of community in choosing a safe medicine. Data were collected in West Java, DKI Jakarta, and South East Sulawesi. Sampling calculation use probability proportional to size sampling and census block. There were 1271 households as samples that analysed.  Data results were analysed using descriptive and index analysis. Knowledge relates to criteria of quality medicines, rules for antibiotics use, and medicines logo. Attitude relates to how to select over the counter medicines, reasons of taking traditional medicines, and opinion about giving half dose of adults medicines to children. Practice relates to source of medicines information, the way to buy prescribe medicines, and reading label information. The results showed that KAP of communities on selecting safe and quality medicines close to 50%. According to score of index analysis are 4.65 (1 to 10 scale), it is recommended that information, education, and communication has to be delivered to communities intensively and continuously by the government
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
  • Back Matter Jurnal Kefarmasian Indonesia Volume 7 Nomor 2 Agustus 2017

    • Authors: Editor JKI
      PubDate: 2017-08-28
      Issue No: Vol. 7 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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