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Jurnal Kefarmasian Indonesia
Number of Followers: 0  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2085-675X - ISSN (Online) 2354-8770
Published by Badan Penelitian dan Pengembangan Kesehatan Homepage  [6 journals]
  • Front Matter Volume 8 Nomor 1

    • Authors: Editor JKI
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Pengaruh Iradiasi Sinar Gamma terhadap Kandungan Flavonoid dan Tanin Total
           Teh Putih (Camellia sinensis L.) dan Benalu Teh (Scurulla atropurpurea BL.

    • Authors: Bina Lohita Sari, Dien Puji Rahayu, Dadan Rohdiana, Selvi Nurlita, Putri Siti Sahara
      Abstract: Camellia sinensis L. leaves, commonly known as white tea, are cultivated from unfurled bud leaves and protected from the sun while were handpicked. Scurulla atropurpurea [BL] Dans is well-known as loranthus of tea. The active compounds of both samples are flavonoid (flavanol, flavonol) and tannin. High humidity conditions can damage the simplicia of medicinal plants in the long-term storage process.The irradiation process with gamma rays can extent the shelf life of simplicia.Gamma irradiation is one of the most effective methods to extend the shelf life of simplicia. Both simplicia were irradiated in room temperature at 60Co source at doses of 0; 2.5; 5; 7.5; 10 and 12.5 kGy. Irradiation simplicia was immediately extracted with microwave assisted extraction (MAE) using 60% ethanol solvent to produce white tea and loranthus of tea extract. Flavonoid and total tannin content were determined using aluminium chloride and folin-ciocalteau methods. Flavonoids and total tannin in the tea samples were 2.56; 2.50; 3.73; 3.14; 2.68; 2.34 mgQE/g and 109.67; 132.87; 149.40; 107.29; 141.82;134.95 mgGAE/g, respectively. Meanwhile in the loranthus of tea were 7.10; 5.68; 5.79; 8.84; 5.01; 5.44 mgQE/g and 60.34; 58.61; 58.59; 71.37; 54.16; 65.99 mgGAE/g, consecutively. Results of the research showed that radiation dose of 5 kGy was found to be effective dose for white tea whilest 7.5 kGy for loranthus of tea to reach highest flavonoid and total tannin content.
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Antihyperpigmentation Effect of The Combination of Turmeric (Curcuma
           domestica Val.) and Bitter Melon Leaves (Momordica Charantia L.) Ethanol
           Extracts on Guinea Pig Skin

    • Authors: Risha Fillah Fithria, Yance Anas, Erika Indah Safitri
      Abstract: Turmeric (T) and Bitter Melon leaves (BM) extract has been proven in decreasing melanin contents in in vitro study, but their single extracts effects were lower than the positive control. A study confirmed the combination of plants extracts had melanogenic effect better than the positive control and their single extracts. This study aimed to investigate the anti-hyperpigmentation effect of the combination of T and BM extract on guinea pig skin and compared with the positive control group. This study used a post-test control design. Twenty-five guinea pigs were divided into 5 groups. The negative control group was given by dimethyl sulfoxide; the positive control group was given by a pharma cream that consists of hydroquinone, tretinoin, and fluocinolone acetonide. The combination of extracts was given to experimental groups with doses 500 µg/mL of T and 200 µg/mL of BM; 750 µg/mL of T and 400 µg/mL of BM; 1.000 µg/mL of T and 600 µg/mL of BM, respectively. All groups exposed to UV-B light in 2 minutes/day for 2 weeks. Each experimental group was given 1 ml combination extract once a day for 2 weeks and in the last step, skin biopsies were done. The histopathological examination was conducted by staining with Fontana-Masson and Nuclear Fast Red. The average percentage of melanin area were compared in all group and analyzed with the Kruskal Wallis test followed by Mann-Whitney test with 95% of confidence level. The result showed group-2 and 3 had the better effect than pharma cream.
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Studi Klinis Ramuan Jamu Antihipertensi pada Pasien Hipertensi Derajat I

    • Authors: Agus Triyono, Zuraida Zulkarnain, Tofan Aries Mana
      Abstract: Hypertension is a risk factor for cardiovascular disease. Hypertension is one of the main causes of high mortality and morbidity in Indonesia. Utilization of medicinal herbs is an  alternative for the treatment of hypertension. The study aimed to determine the efficacy of the herbs combination compared to HCT and evaluated the safety for hypertention stage I. This research method using an open-label randomized clinical trials with intervention for 56 days. Measurement of day-56 (D-56) showed that  herbs decreased sistolic blood pressure to 130.15 + 17.59 mmHg and diastolic at 83.82+9.53 mmHg. There was a significant decrease p = 0.000 (p <0.05) in both systolic and diastolic at the end of intervention. In comparison between combination herbs and HCT, there was not significant difference (p> 0.05), with p mean systolic blood pressure (p = 0.370) and mean diastolic blood pressure (p = 0.412). Liver function parameters (SGOT, SGPT) and renal function (urea, creatinine) is still in normal range at the end of intervention. This study showed that herbs combination was an equally effective compared to HCT and safe for  hypertension stage
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Efek Antibakteri dari Kombinasi Minyak Atsiri Masoyi dan Kayu Manis

    • Authors: Rollado Rollando, Rehmadanta Sitepu
      Abstract: Essential oils had been used as antibacterial, antifungal, antiviral, antioxidant and insecticidal in medicine and industry. Increasing the usage of essential oils as an alternative medication also lead more research of essential oils in vivo and in vitro. Cinnamon with cynamaldehide as a main active substance and masoyi with massoia lacton as a main active substance have antibacterial activity. This study aimed to determine the activity of masoyi and cinnamon essentials oils combination in E.coli, S.aureus, and P. aeruginosa bacteria. The research encompasses antibacterial activty screening and antibacterial evaluation. The aims of essential oil activity screening using Kirby-Bauer method is to find the optimum concentration of masoyi and cinnamon essentials oils combination. Determination of MIC50, MIC90, and MBC concentration is using microdilution method. Kirby-Bauer test results showed the highest inhibitory concentration that had bactericidal effect to E.coli, S.aureus, and P.aeruginosa were the combination of 5% masoyi and 10% cinnamon. 
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Potensi Ekstrak Biji Coklat (Theobroma cacao Linn) sebagai Inhibitor
           Tirosinase untuk Produk Pencerah Kulit

    • Authors: Aprillia Kurniasari, Effionora Anwar, Joshita Djajadisastra
      Abstract: Hyperpigmentation is a condition of excessive skin pigments production. The skin colour is strongly influenced by the presence of melanin that marked by the melanin tyrosinase enzyme activity. Cocoa (Theobroma cacao Linn) is one of the ingredients which are rich in flavonoids include polyphenolic compounds that used as antioxidants and a tyrosinase inhibitor. The aim of this study is to examine the potential of the cocoa bean extract as a tyrosinase inhibitor for skin lightening active ingredients. The method of the study was experimental laboratories, among others: total flavonoid and tyrosinase inhibitory activity assay. The result of this research was ethanol extract of cocoa had tyrosinase inhibitor activity. The inhibitory activity could be seen from the IC50 for monophenolase activity were 352.05 μg mL-1 and for diphenolase activity 836.20 μg mL-1 respectively. This value is greater than kojic acid, for monophenolation was 2.38 μg mL-1 and diphenolation was 10.74 μg mL-1. The total flavonoids content was 0.05% w/w so that the ethanol extract of the cocoa bean is a natural product that potential to be used in the formulation of skin lightening cream in the pharmaceutical sciences.
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Analisis Biaya Tuberkulosis Paru Kategori Satu Pasien Dewasa di Rumah
           Sakit di DKI Jakarta

    • Authors: Ida Diana Sari, Max Joseph Herman, Andi Leny Susyanty, Amir Su'udi
      Abstract: In 2014, new TB sufferers in Indonesia reached 324,579. An analysis of the cost aims to calculate the cost of treatment of adult category I pulmonary TB patient and the results obtained. The study was conducted in 5 District General Hospitals in Jakarta in 2014 with new adult TB patients treated as samples. Patients’ and attendants’ characteristics, the costs incurred, and treatment outcome were collected through in-depth interviews at every visit for 6 months. The results showed that 64,5% of patients are men aged between 18-70 years and 80,6% of patients using the BPJS. The number of visits for 6 months is 10 times in average (ideally 16 times). With a utilization of hospital by 10 times, then the total direct costs amount to Rp1.228.867, the total indirect costs are Rp614.670, and the total costs of the overall TB treatment are Rp1.843.537 with an average of Rp307.256 per month. The largest components of direct costs are the cost of the drug and the largest component of indirect costs are the cost of TB patient’s attendants. Drug compliance (68,9%) and being cured (41,9%) of TB patients treated for 6 months are far from expectations.
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Kandungan Gizi Mikro (Besi, Seng), Nitrit dan Formalin pada Daging Sapi
           dari Pasar Tradisional dan Swalayan

    • Authors: Sukmayati Alegantina, Ani Isnawati, Winarsih Winarsih, Fitrah Ernawati, Nelis Imanningsih, Herni Asih Setyorini
      Abstract: Beef is a nutritious food to consume due to its nutrient content that needed by human body. The demand for beef increases in certain times, such as in religion event or in the holiday. Special treatment is needed for the slaughter time to ready to consume beef, such as freezing or refrigerating. This research aimed to identify the quality of fresh beef as well as frozen beef in the traditional market and frozen beef in supermarket regarding its content of micronutrient (iron and zinc), preservatives (nitrate), and another dangerous additional food (formaldehyde) in cub roll, upper thighs, and lower thighs of beef. This was a cross-sectional and laboratory observational designed research. The result showed that iron, zinc, and nitrite concentration on fresh beef and frozen beef in traditional market and supermarket on any side of the beef sample was not significantly different (p>0.05). Nitrite concentration was within the permitted level. All beef samples also had not contain formaldehyde.
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Studi Kesesuaian Sumber Daya dengan Pelayanan Kesehatan Tradisional Rumah
           Sakit Pemerintah di Provinsi DI Yogyakarta, Jawa Tengah dan Jawa Timur

    • Authors: Suharmiati Suharmiati, Lestari Handayani, Lulut Kusumawati, Tri Juni Angkasawati
      Abstract: Traditional health services (THS) in hospitals are expected to support conventional services formally applied in Indonesia. Nonetheless, until now there is no known information about the suitability of the existing THS resources. This research was conducted to analyze the suitability of resources for the means of how it is done, with descriptive method, cross sectional design. The sample was determined purposively by 1 (one) government hospital every regency/city that provide more than one traditional health service and operated before or since 2014. The research subject was 2 informants every hospital consisting of unit head of traditional health services and administration staff. The results showed that most THS types were licensed, have SOPs and have appropriate resources. The existing human resources are equally good in the THS of the herb as well as the skill unit with the tools that consist of both trained and untrained physicians, diploma of traditional healers, diploma ofnursing, and or high school graduates, but none of the traditional healh service units have pharmacists. Types of Standard Herbal Medicines is obtained from herbal medicine and pharmaceutical industry although in some other units also available herbs and phytopharmaca. There is a suitability of resources and treatment at the tradisional health service in hospitals
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
  • Back Matter Volume 8 Nomor 1

    • Authors: Editor JKI
      PubDate: 2018-02-26
      Issue No: Vol. 8 (2018)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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