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Journal Cover Advances in Pharmacology and Pharmacy
  [6 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2332-0036 - ISSN (Online) 2332-0044
   Published by Horizon Research Publishing Homepage  [54 journals]
  • Erythrosine Incorporated Fast-Dissolving Patches for Dental Plaque

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Pharmacology and Pharmacy  Volume  5  Number  1  Prasopchai Tonglairoum   Theerasak Rojanarata   Tanasait Ngawhirunpat   Prasert Akkaramongkolporn   Ruchadaporn Kaomongkolgit   and Praneet Opanasopit   The aim of this study was to develop erythrosine-loaded electrospun polyvinyl pyrrolidone/ hydroxypropyl-β-cyclodextrin (PVP/HPβCD) fiber patches for plaque disclosing. The fiber patches had been fabricated via electrospinning process and were characterized using scanning electron microscope (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential scanning calorimeter (DSC) and powder X-ray diffractometry (PXRD). The fiber patches were then further evaluated for wetting and integration abilities, mechanical properties, loading efficiency, loading capacity and release characteristic. These erythrosine-loaded fiber patches exhibited excellent wetting and disintegration properties and prompt released the erythrosine form the patches after contacted with saliva. These erythrosine-loaded fiber patches could be exploited as a plaque-disclosing material. However, further in vivo studies are needed for the application.
      PubDate: Apr 2017
  • Subchronic Amitriptyline Influences Open-field Behaviours and Spontaneous
           Working-memory in Healthy Mice

    • Abstract: Publication date:  Apr 2017
      Source:Advances in Pharmacology and Pharmacy  Volume  5  Number  1  Onaolapo Olakunle James   Olabintan Olusegun Oyewole   and Onaolapo Adejoke Yetunde   Objective: We assessed the effects of amitriptyline on open-field locomotion, stereotypic behaviours and spatial working-memory in healthy mice. Method: Five groups of mice were administered vehicle (distilled water), scopolamine (2 mg/kg), or one of three doses of amitriptyline (5, 10 and 15 mg/kg) for 21 days. Behaviours were assessed after the first and final dose of treatment. Result: Administration of the first dose of amitriptyline was associated with enhanced open-field horizontal locomotion, rearing and grooming; with repeated administration, there was suppression of horizontal locomotion and rearing. A dose-related decrease in Y-maze and radial-arm maze spatial working-memory was also observed after repeated administration. Compared to scopolamine, amitriptyline was associated with a significant reduction in open-field behaviours, but a significantly-higher spatial working-memory score. Conclusion: Repeated administration of amitriptyline in healthy mice was associated with suppression of locomotion and grooming; working-memory deficits were also observed. However, working-memory task performance is significantly better than the scopolamine group.
      PubDate: Apr 2017
  • Purification, Characterization and Antioxidant Activity of Green Seaweed
           Codium sp

    • Abstract: Publication date:  Jun 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  2  G. Kallswari   S. Mahendran   P. Subalakshmi   T. Shankar   and P. Ponmanickam   In the present study the Codium sp. polysaccharide was extracted and partially purified in DEAE cellulose. The polysaccharide was estimated for carbohydrate, sulfate content and uronic acid. The elemental analysis of polysaccharides was analyzed for carbon, hydrogen, nitrogen and sulfur. The antibacterial activity of polysaccharide showed maximum 19 mm of inhibition zone against Bacillus cereus and 12 mm of inhibition zone against Xanthomonas sp. Free radical scavenging activity of polysaccharide from Codium sp. was assayed for total antioxidant capacity, reducing power, hydrogen peroxide scavenging activity, DPPH, ABTS, hydroxyl scavenging assay, superoxide anion radical scavenging and nitric oxide. The green seaweed Codium sp. polysaccharide showed rich sources of antibacterial and antioxidant activity.
      PubDate: Jun 2016
  • Drug Utilization Study in Ophthalmology Outpatients in a Tertiary Care

    • Abstract: Publication date:  Jun 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  2  Hardik V Vaniya   Nishita H Darji   Vikas R Patel   and Devdatta J Gohel   Aims: The present study was carried out to describe the patterns of prescription and drug use in Ophthalmology outpatients at GG hospital, Jamnagar, Gujarat, India. Methods: Total of 600 patients were included during 3 months duration and average number of drugs per encounter, percentage of drugs prescribed by generic name, percentage of encounters with antibiotics prescribed, percentage of encounters with an injection prescribed, percentage of drugs prescribed from the WHO Essential Drug List 2015, number of fixed dose combinations prescribed and percentage of antimicrobial agents prescribed were analyzed. Results: Prescription analysis showed that the average number of drugs per prescription was 3.20%. Eye drops were the most commonly prescribed (66.8%) dosage form, followed by ointment (18.4%), capsules (8.66%) and tablets (6%). Dosage forms were recorded in 99.2% drugs, information about the frequency of drug administration was present in 96% of the drugs and duration of therapy was recorded in 84.7% of the drugs prescribed. The drug classes that were used most frequently were Antibiotics (45%), Ocular lubricants (24.7%), NSAIDS (17.4%) and Anti-allergy medications (8.1%). Conclusion: Common prescription errors were minimum. However polypharmacy was common.
      PubDate: Jun 2016
  • Pharmaceutical Care in Tbilisi Pharmacies

    • Abstract: Publication date:  Feb 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  1  N. Nemsitsveridze   N. Gorgaslidze   T. Chumburidze   N. Dughashvili   T. Zarkua   and S. Voronovi   Pharmaceutical care represents the patient-oriented future profession that is focused on identification, eradication and prevention of the problems connected to the drug treatment. The aim of the study was to detect the role of pharmacist in treatment. Thus it was necessary to find out doctors and pharmacists opinion about this topic. The method of the study was anonymous survey, of pharmacists and doctors. 'Pharmaceutical care'' in Tbilisi pharmacies was evaluated. We performed the analysis of the statistical data from the anonymous questionnaires delivered to 30 pharmacists and 30 physicians. Concerning the character of the request, frequently it is connected to the drug selection which is issued without any prescription, according to the 95% (45% often +50% rarely) of the respondents, majority of the patients request the original medicine to be changed with the generic one, which is according to their opinion determined by the high price of the original medicine. On the question about how many patients are advised, 54% of the pharmacists responded that every day from 50-70 patients address them to select drug or give consultation concerning the drug treatment. On the question about how frequently are patients redirected to the doctors, according to the questioning that consists of 50 %, which means that half of the patients' needs consultation of the doctors and pharmacist warn them concerning this issue. For the reason to find the dependence of the doctors on pharmacist's care we made internet survey. 65% of doctors believe that patient care belongs exclusively to the physician and only 35% of responders agreed to share this function with the pharmacist. In conclusion for avoiding misunderstanding between physicians and pharmacists and also for solving other problems detected during this study it is necessary to upgrade the qualification of pharmacists in clinical issues.
      PubDate: Feb 2016
  • Toxicological Impact of Co-treatment with Rifampicin and Tenofovir on the
           Renal Function of Male Albino Rats

    • Abstract: Publication date:  Feb 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  1  Adikwu Elias   Igbans Rejoice Obele   and Brambaifa Nelson   This experimental study comparatively evaluated the toxicological effects of treatment with tenofovir, rifampicin and tenofovir- rifampicin (TDF-RIF) combination on kidney function and histology of male albino rats. Male albino rats used in this study were divided into five (5) groups A-E of sixteen (16) animals each. Animals in group A, (placebo control) were treated orally with normal saline, group B (solvent control) were treated orally with 0.1% ethanol while groups C-E were treated orally with 80 mg/kg of RIF, 32 mg/kg of TDF and a combination of TDF- RIF for 2-8 weeks respectively. Animals were sacrificed at the end of drug therapy, blood sample was collected, centrifuged and serum extracted for creatinine, urea and, uric acid evaluation. Kidney was harvested, weighed and examined for histopathological changes. Treatment with tenofovir-rifampicin combination had no significant (p0.05) time-dependent increases in serum creatinine, urea and uric acid levels were observed in animals treated with tenofovir-rifampicin combination when compared with treatment using individual doses of these drugs . Acute tubular necrosis, enlarged glomeruli and obliteration of the Bowman's capsule were observed in the kidneys of rats treated with tenofovir, rifampicin and a combination of tenofovir-rifampicin. This result shows that treatment with tenofovir-rifampicin combination in the management of human immunodeficiency virus /tuberculosis (HIV/TB) co-infection may not be associated with synergistic renal toxicity at the dose level used in this study.
      PubDate: Feb 2016
  • A Review on Ethnobiological & Medicinal Potential of Capparaceae Family
           Plant: Capparis decidua (Forssk.) Edgew

    • Abstract: Publication date:  Dec 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  3  Prashant Kumar Dhakad   Pramod Kumar Sharma   and Sokindra Kumar   Rajasthan state is rich in flora of xerophytic plants. Capparis decidua (Forssk.) Edgew. is a wild bushy plant found in hot arid regions. This plant has wide range of distribution in many parts of India. Ethnobiologically, this plant is useful as its various parts like immature flower buds, semi-mature fruits, young shoots with small leaves are pickled for use as a condiment and traditional people use this plant in treating ailments like digestive diseases, anodyne, sudorific, constipation, gout, cough, flu, dropsy, palsy, asthma, and intestinal worms, lumbago, odontalgia. Capparis decidua (Forssk.) Edgew. contains chemical compounds like alkaloids, flavanoids, terpenoids, phenolic compounds, steroids, vitamins, quarternary ammonium compounds and many more phytoconstituents that are responsible for its medicinal value. Different parts of this plant like seed, root, stem, flowers, fruits and leaves have medicinal importance and has shown numerous pharmacological activities like antimicrobial, antibacterial, antifungal, anti-inflammatory, antioxidant, hepatoprotective, anthelmintic, antidiabetic, antisebum, antihyperlipidemic, antisclerotic, antitermite, antiplaque, analgesic, sedative and anticonvulsant. Economic importance of this plant has tended for harvesting, yield and marketing specifically in Thar Desert. Future potential of this crop is very promising as it is a drought and heat tolerant plant which makes it a good weather forecasting species; also it provides people with food (pickle & vegetable), fodder, wood and fuel. The presence of numerous phytoconstituents makes it a medicinally important crop for treating deadly diseases. This review covers taxonomy, distribution, phytochemicals, and nutritional value, and commercial value, traditional and pharmacological aspects of Capparis decidua (Forssk.) Edgew.
      PubDate: Dec 2016
  • Anti-inflammatory Activity of an Ornamental Plant Plumeria Obtusa

    • Abstract: Publication date:  Dec 2016
      Source:Advances in Pharmacology and Pharmacy  Volume  4  Number  3  Amogh R. Lotankar   Altamash J. Momin   Shaijesh Wankhede   and Jyoti B. Sharma   Aims: An experiment was conducted to evaluate the anti-inflammatory effects of ethanolic bark extract of Plumeria obtusa. Material and method: Anti-inflammatory activity was evaluated by using two different animal models namely cotton pellet method and carrageenan induce paw edema in male Wistar rats at a dose of 100,200 and 400 mg/kg respectively. Results: Phytochemical examination of the extract exposed the existence of alkaloids, flavonoids, tannins and terpenoids. The ethanolic extract elicited highly significant (p
      PubDate: Dec 2016
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