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Journal Cover Biomedical Research and Therapy
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2198-4093 - ISSN (Online) 2198-4093
   Published by Vietnam National University Homepage  [1 journal]
  • Perception and attitude of University students toward green tea

    • Authors: Mubashir Mehmood, Haroon Haroon, Tauseef Ahmad, Muhammad Khan
      Pages: 697 - 698
      Abstract: Globally, green tea is the second most popular used drink after the water. This survey was conducted at Shaheed Benazir Bhutto University Dir (Upper) Khyber Pakhtunkhwa Pakistan, in order to determine the perception and attitude of students toward green tea. A total of 45 male students were interviewed. Majority of the students use black tea (93%). The green tea is being used to reduce weight and cholesterol level.
      PubDate: 2016-07-30
      Issue No: Vol. 3, No. 7 (2016)
  • Resurrection of Neurodegenerative diseases via Stem cells

    • Authors: Siranjeevi Nagaraj
      Pages: 699 - 706
      Abstract: Neurodegenerative diseases (NDDs) are complex disorders that degenerates central nervous system. To this end, we have achieved only  palliative treatments and their success is limited. Emerging studies suggest stem cells could be an alternative to recover lost neural network. Transplanting stem cells for replacing damaged neurons is a pivotal step in cell replacement therapies. In this article, NDDs and their pathology, current methods of combating NDDs and potentiality of stem cells in treating NDDs have been reviewed briefly. In addition to this ,  technical issues that hamper clinical applications of stem cells in creating cellular models and grafted cells for neuron resurrection have been discussed.
      PubDate: 2016-07-30
      Issue No: Vol. 3, No. 7 (2016)
  • Evaluating the ameliorative potential of plant flavonoids and their
           nanocomposites in bleomycin induced idiopathic pulmonary fibrosis

    • Authors: Srabani Kar, Silpak Biswas, Ena Ray Banerjee
      Pages: 707 - 722
      Abstract: Introduction: Pulmonary Fibrosis can severely disrupt lung function. The cause of Idiopathic Pulmonary Fibrosis (IPF) is still unclear. The treatment currently available for IPF provides minimal benefits. Bleomycin is used in research to induce experimental pulmonary fibrosis in animals. Plant flavonoids such as fisetin and curcumin are known for their anti-inflammatory properties. The aim was to demonstrate the path of physiological changes in bleomycin induced IPF and to further evaluate the reversal and ameliorative potentials of some plant flavonoids and their nanocomposites. Bleomycin administration is known to damage the lung epithelial cells resulting in lower cell numbers. Results: Our colony forming assay in BALF also demonstrated a reduction (1.65 fold) in colony-forming unit after bleomycin administration. The number of colonies increased upon treatment with fisetin(1.20 fold) and curcumin (1.13 fold) respectively. MTT proliferation assay demonstrated a significant increase in the number of viable cells upon treatment with curcumin (1.42 fold) and fisetin (1.74 fold) respectively, in the lung. The NBT assay demonstrated a significant effect of curcumin in BALF, lung and peripheral blood. A significant effect of fisetin was observed in BALF and peripheral blood. Conclusion: These findings were also supported by the histological analyses of the lung samples. Curcumin showed highestpotential for the treatment of IPF and fisetin showed its ameliorative effect.
      PubDate: 2016-07-30
      Issue No: Vol. 3, No. 7 (2016)
  • Extenuating the role of Ficus virens Ait and its novel bioactive compound
           on antioxidant defense system and oxidative damage in cigarette smoke
           exposed rats

    • Authors: Danish Iqbal, Mohammad Salman Khan, Amir Khan, Saheem Ahmad
      Pages: 723 - 732
      Abstract: Introduction: Production of free radicals is associated with cigarette smoke (CS) which in turn generates oxidative stress, could be responsible for alterations in the activities of enzymatic and non-enzymatic antioxidants that links with atherosclerosis. Methods: Therefore, the putative preventive effects of F. virens extract and its bioactive compound (F18), n-Octadecanyl-O-α-D-glucopyranosyl(6’→1’’)-O-α-D-glucopyranoside were investigated on overall enzyme and non-enzymatic defense system and in oxidative stress CS-exposed rats. Results: The enzymatic activities of hepatic and lung CAT, SOD, Gred and GST in CS exposed rats were significantly decreased, while Gpx activity in CS exposed rats was increased. Similarly, hepatic and lung GSH content was reduced when compared to value of normal control group. Simultaneous administration of FVBM extract (50 and 100 mg/rat) and F18 bioactive compound (1 mg/rat) significantly increases hepatic and lung CAT, SOD, Gred and GST activity as well GSH concentration coupled with decrease in Gpx level in CS-exposed stress rats. Moreover, our histological observations concludes the pulmonary congestion, thickening of interalveolar septa and foci of collapsed alveoli with subsequent dilation of the adjoining alveolar spaces as well as development of large irregular spaces in rats lung exposed to cigarette smoke. Similarly, the liver also showed morphological alterations with congestion in central vein, portal inflammation and necrosis in CS-exposed rats. These morphological changes reversed significantly after treatment with FVBM extract and F18 compound. Conclusion: Thus biochemical and histopathological studies suggested that, FVBM extract and F18 showed its protective nature against CS-exposed rats.
      PubDate: 2016-07-30
      Issue No: Vol. 3, No. 7 (2016)
  • Taraxacum officinale dandelion extract efficiently inhibited the breast
           cancer stem cell proliferation

    • Authors: Ngu Van Trinh, Nghi Doan-Phuong Dang, Diem Hong Tran, Phuc Van Pham
      Pages: 733 - 741
      Abstract: Background: Breast cancer stem cells (BCSCs) play an important role in breast cancer initiation, metastasis, recurrence, and drug resistance. Therefore, targeting BCSCs is an essential strategy to suppress cancer growth. This study aimed to evaluate the effects of dandelion Taraxacum officinale extracts on BCSC proliferation in vitro in 2D and 3D cell culture platforms. Materials and Methods: The BCSCs were maintained under standard conditions, verified for expression of CD44 and CD24 surface markers, and transfected with GFP before use in experiments. In the 2D model, the BCSCs were cultured as adherent cells in standard culture plates; in the 3D model, the BCSCs were cultured on low-adherent plates to form spheroids. The effect of Dandelion extracts on proliferation of BCSC was assessed by evaluating induction of cell death, expression of genes of death receptor signaling pathways, and production of reactive oxygen species (ROS) by BCSCs. Results: BCSCs formed spheroids as microtumors in vitro and exhibited some in vivo characteristics of tumors, such as increased expression of N-cadherin and Slug, decreased expression of E-cadherin, capacity to invade into the extracellular matrix (ECM), and presence of a hypoxic environment at the core of tumor spheroids. The dandelion extracts significantly inhibited BCSC proliferation in both two-dimensional (2D) and three-dimensional (3D) models of BCSCs. However, the IC50 value of dandelion extracts in BCSCs in the 3D model was much higher than that in the 2D model. The results also demonstrated that BCSCs treated with Dandelion extracts showed increased expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptor 2 (TRAILR2; i.e. death receptor 5; DR5). Moreover, treatment induced expression of DR4. Treatment with methanol dandelion extract enhanced production of ROS in BCSCs. Conclusion: Dandelion extracts are promising extracts for the treatment of breast tumors. The effect of methanol extract (with dandelion extract) was better than that for ethanol extract. Importantly, BCSCs in 3D exhibited stronger drug resistance than those in 2D. In summary, our results indicate the strong potential of dandelion extracts as anti-cancer agents and rational use for drug development.
      PubDate: 2016-07-30
      Issue No: Vol. 3, No. 7 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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