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Biomedical Research and Therapy    [3 followers]  Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 2198-4093 - ISSN (Online) 2198-4093
     Published by Vietnam National University Homepage  [1 journal]
  • Platelet-rich plasma in regenerative medicine
    • Authors: Guhta Ra Hara, Thaha Basu
      Abstract: Platelet-rich plasma (PRP) contains at least seven growth factors including epidermal, platelet-derived, transforming, vascular endothelial, fibroblast, insulin-like and keratinocyte growth factor. The therapeutic effect of PRP occurs because of the high concentration of these growth factors compared with those found in normal plasma. In recent years, PRP is widely used across many clinical fields, especially in regenerative medicine. This review aimed at presenting an overview of the applications of PRP in regenerative medicine. The mechanisms of PRP effects on healing are also stated in this review.
      PubDate: 2014-03-09
      Issue No: Vol. 1, No. 1 (2014)
  • Safety of mesenchymal stem cell transplantation
    • Authors: Matthie Robert
      Abstract: To date, adult stem cell therapy has some achievements in the treatment of chronic disease. However, some risks in stem cell transplantation still serve as high barriers obstructing the pulling of these therapies into clinical use. Tumorigenecity is of almost concern after it is injected into patients. However, all clinical studies indexed in PubMed  showed that there were no cases of tumor after transplantation. Especially in recent study published in Cell Death and Disease, Wang et al. (2013) showed that long-term cultured mesenchymal stem cells could develop the genomic mutations but cannot undergo malignant transformation. Moreover, the study also revealed these stem cells as capable of forming tumors. This commentary assesses the data generated to date, and discusses the conclusions drawn from various studies.
      PubDate: 2014-02-19
      Issue No: Vol. 1, No. 1 (2014)
  • Symptomatic knee osteoarthritis treatment using autologous adipose derived
           stem cells and platelet-rich plasma: a clinical study
    • Authors: Khanh Hong-Thien Bui, Triet Dinh Duong, Nhan Thanh Nguyen, Thanh Duc Nguyen, Vien Tuong Le, Viet Thanh Mai, Nhan Lu-Chinh Phan, Dung Minh Le, Ngoc Kim Phan, Phuc Van Pham
      Abstract: Osteoarthritis is one of the most common diseases, and it affects 12% of the population around the world. Although the disease is chronic, it significantly reduces the patient’s quality of life. At present, stem cell therapy is considered to be an efficient approach for treating this condition. Mesenchymal stem cells (MSCs) show the most potential for stem cell therapy of osteoarthritis. In fact, MSCs can differentiate into certain mesodermal tissues such as cartilage and bone. Therefore, in the present study, we applied adipose tissue-derived MSCs to osteoarthritis treatment. This study aimed to evaluate the clinical efficiency of autologous adipose tissue-derived MSC transplantation in patients with confirmed osteoarthritis at grade II and III. Adipose tissue was isolated from the belly, and used for extraction of the stromal vascular fraction (SVF). The SVF was mixed with activated platelet-rich plasma before injection. The clinical efficiencies were evaluated by the pain score (VAS), Lysholm score, and MRI findings. We performed the procedure in 21 cases from 2012 to 2013. All 21 patients showed improved joint function after 8.5 months. The pain score decreased from 7.6±0.5 before injection to 3.5±0.7 at 3 months and 1.5±0.5 at 6 months after injection. The Lysholm score increased from 61±11 before injection to 82±8.1 after injection. Significant improvements were noted in MRI findings, with increased thickness of the cartilage layer. Moreover, there were no side-effects or complications related to microorganism infection, graft rejection, or tumorigenesis. These results provide a new opportunity for osteoarthritis treatment. Level of evidence: IV.
      PubDate: 2014-02-07
      Issue No: Vol. 1, No. 1 (2014)
  • A comparison of umbilical cord blood-derived endothelial progenitor cell
           transplantation and mononuclear cell transplantation for the treatment of
           acute hindlimb ischemia in a murine model
    • Authors: Ngoc Bich Vu, Anh Nguyen-Tu Bui, Van Ngoc-Le Trinh, Lan Thi Phi, Ngoc Kim Phan, Phuc Van Pham
      Abstract: Introduction: Acute lower limb ischemia is a common peripheral artery disease whose treatment presents many difficulties. Stem cell transplantation is considered a novel and promising method of treating this disease. Umbilical cord blood (UCB) is rich in stem cells, including hematopoietic stem cells (HSCs), mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs). However, historically, banked umbilical cord blood has been used mainly to treat blood-related diseases. Therefore, this study compared the efficacy of umbilical cord blood-derived mononuclear cells (UCB-MNCs) with EPC transplantation for the treatment of acute hindlimb ischemia (ALI) in mouse models.Methods: MNCs were isolated from UCB by Ficoll gradient centrifugation, after which the EPCs were sorted based on CD34+ and CD133+ markers and cultured according to a previously published protocol. To induce ALI, mice were immuno-suppressed using busulfan (BU) and cyclophosphamide (CY), after which the femoral arteries were burned. Induction of ALI in the immune suppressed mice was confirmed by the grade of tissue damage, pedal frequency in water, tissue edema, changes in histology, total white blood cell count, and white blood cell composition. Model mice were injected with a dose of MNCs or EPCs and un-treated control mice were injected with phosphate buffered saline. The efficiency of treatment was evaluated by comparing the grade of tissue damage between the three groups of mice.Results: Mice aged 6–12 months were suitable for ALI, with 100% of mice exhibiting ischemia from grade I 10%, grade III 50%, grade IV 40%. For all ALI mice, a gradual increase in pedal frequency in water, increased tissue edema, necrosis of muscle tissue, and (Andaz, 1993 #6)loss of hindlimb function were observed after 20 days. Transplanted MNCs and EPCs significantly improved hindlimb ischemia compared with control treatment. Moreover, EPC transplantation significantly improved hindlimb ischemia compared with MNC transplantation. Following EPC and MNC transplantation, 44.44% and 33.33% of the mice recovered fully (grade 0), respectively. Specifically, all recovered mice exhibited hindlimb activities similar to those of normal mice
      PubDate: 2014-02-07
      Issue No: Vol. 1, No. 1 (2014)
  • Welcome to Biomedical Research and Therapy
    • Authors: Phuc Van Pham
      Abstract: On behalf of the Laboratory of Stem Cell Research and Application (SCL) and the Biomedical Research and Therapy’ editorial team, we would like to extend a warm welcome to you.

      Biomedical Research and Therapy is the official journal of SLC. Biomedical Research and Therapy is a new journal, peer-reviewed, a highly visible, open access forum, rapid speed publication with new ideas and advanced studies in biomedical science. The mission of this journal is to deliver significant, well-documented studies to biomedical researchers and doctors.

      Biomedical Research and Therapy focuses on basic, translational and clinical research into molecular therapeutics and cellular therapies, including animal models and clinical trials. Subject areas suitable for publication include, but are not limited tothe following fields: gene editing, gene correction, immunotherapy, cell/stem cell therapy, targeting therapy, gene therapy,stem cell gene therapy, gene transfer, gene silencing, gene expression control, DNA vaccine, biochemistry/biophysics, cellbiology, developmental biology, genetics, immunology, molecular biology, protein science, structural biology, translationalmedicine, clinical trials.
      PubDate: 2014-01-08
      Issue No: Vol. 1, No. 1 (2014)
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