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Journal Cover Biomedical Research and Therapy
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2198-4093 - ISSN (Online) 2198-4093
   Published by Vietnam National University Homepage  [1 journal]
  • Umbilical cord derived stem cells (MODULATIST) expressed high
           immunomodulation compared to adipose tissue, bone marrow derived
           mesenchymal stem cells

    • Authors: Phuc Van Pham, Ngoc Bich Vu, Ngoc Kim Phan
      Abstract: Introduction: Mesenchymal stem cells (MSCs) are promising stem cells for regenerative medicine. Recently, clinical applications of MSCs significantly increase, especially in immune diseases. Autologous transplantation is considered as safe therapy. However, it also contains some disadvantages such non-stability of MSC quality from patient to patient, time-consuming for culture and proliferation. Therefore, recently allogeneic MSC transplantation is suggested as a replacement for autologous transplantation. “Off the shelf” MSC products, so-called as stem cell drugs, rapidly growth with some approved products in some countries as Canada, Korea, Japan… This study aimed to evaluate a new stem cell drug – ModulatistTM with immunomodulation properties compared to MSCs derived from bone marrow (BMMSC), and adipose tissue (ADSC). Methods: ModulatistTM was produced from MSCs derived from Wharton’s jelly and umbilical cord in the animal composition free medium according to GMP compliant procedures. Bone marrow and adipose tissue derived MSCs were isolated and proliferated in standard condition with DMEM/F12 medium supplemented with FBS. Immunomodulation properties between them were compared each other such as allogenic T cell suppression, cytokine release. Results: The results showed that ModulatistTM exhibited the immunomodulation capacity higher than BMMSC and ADSC in vitro. ModulatistTM strongly suppressed allogeneic T cells, the lowest level of interleukin production compared to BMMSC and ADSCs. Conclusion: These results showed that ModulatistTM is a promising stem cell product for immune disease treatment.
      PubDate: 2016-06-26
      Issue No: Vol. 3, No. 6 (2016)
  • Synergistic effect of chimeric antigen receptors and cytokine-induced
           killer cells: An innovative combination for cancer therapy

    • Authors: Binh Thanh Vu, Dat Tan Le, Phuc Van Pham
      Pages: 653 - 665
      Abstract: In recent years, the combination of gene and immunotherapy for cancer treatment has been regarded as innovative and promising; together, both therapies can help overcome limitations associated with conventional treatments. In order to augment anti-cancer efficacy and to maintain the specificity of antibody therapy, chimeric antigen receptor (CAR)-modified T cells, directed toward tumor-specific antigens, have emerged as a novel and promising therapeutic platform. CARs consist of a B cell receptor (BCR)-derived extracellular domain and T cell receptor (TCR)-associated signaling elements. Cytokine-induced killer (CIK) cells are the effector immune cells that can be activated ex vivo and possess both the anti-tumor potency of T lymphocytes and the non-major histocompatibility complex-restricted elimination of natural killer cells. With their pre-eminent ability for robust proliferation, CIK cells may overcome the main limitations of adoptive immunotherapy strategies. CIK cells have strong tumor cell killing capacity; they are effective against a wide variety of malignant tumors and have been shown to be safe in cancer patients. This review summarizes the characteristics of CARs which make them attractive for in cancer treatment strategies. In addition, the role of CIK cells and the advantages of combining CIK cells with CAR-based therapy will be discussed. Scientific evidence to support their combined therapeutic application will be highlighted, with a focus on how their innovative combination may be translated into cancer clinical trials.
      PubDate: 2016-06-26
      Issue No: Vol. 3, No. 6 (2016)
  • Plasmodium vivax and Plasmodium falciparum are Common Malaria Species in

    • Authors: Tauseef Ahmad
      Pages: 666 - 672
      Abstract: The microbes have a diverse nature, it makes human laugh and cry. Some microbes are fruitful for humans while others are harmful. Infectious diseases are a key problem in the modern world. In the last few decades, million of peoples have died from different diseases, including bacterial, viral, fungal, parasitic, etc. Among these diseases, malaria is one of the major health problems for developing countries including Pakistan. This study was undertaken to provide baseline information about the prevalence of malaria, species distribution and to contribute to the data regarding epidemiology in Pakistan. For a collection of literature, the electronic search engine was used, using different key words i.e. prevalence, species distribution, epidemiology of malaria in Pakistan, etc. The time frame of the obtained articles was from 2000 to 2014. The two species of malaria Plasmodium vivax and Plasmodium falciparum are common in Pakistan.
      PubDate: 2016-07-01
      Issue No: Vol. 3, No. 6 (2016)
  • Separation of Veins and Arteries for estimating Hypertensive Retinopathy
           in Fundus Images

    • Authors: Shafiq Hussain, Muhammad Rehan Faheem
      Pages: 673 - 678
      Abstract: The determinations of Hypertensive Retinopathy (HR) through retinal pictures turn out being a vital issue today since  HR is quickly expanding ailment that is found in eyes. HR happens because of the height of the circulatory strain. The most imperative estimation that is used to analyze HR through retinal pictures is arteriovenous proportion (AVR). This paper depicts a strategy to decide AVR by first section the vessels using match separating method and afterward identify the optic circle to decide the Region of Interest. When the area of interest is discovered, we order the veins into supply routes and veins utilizing Neural Network to decide the AVR. Once the vessels are classified, we separate the arteries and veins based on the color separation. The work is performed  by  using MATLAB R2014. This paper is partitioned into four segments. Area one portrays the introduction. Area two decribes the technique/ systems to decide AVR. Area three depicts the examination of results with some past results. Segment four portrays the conclusion.
      PubDate: 2016-07-01
      Issue No: Vol. 3, No. 6 (2016)
  • A preliminary comparison of dendritic cell maturation by total cellular
           RNA to total cellular lysate derived from breast cancer stem cells

    • Authors: Phong Minh Le, Tram Thi-Bao Tran, Binh Thanh Vu, Phuc Van Pham
      Pages: 679 - 686
      Abstract: Introduction: Dendritic cells (DCs) have been widely considered as the most potent antigen-presenting cells. As such, DC-based vaccines are regarded as a promising strategy in cancer vaccination and therapy. This study compared the maturation of DCs induced by total cellular RNA and cell lysate (i.e. nucleic acid and protein). Methods: Both total RNA and cell lysate were isolated from breast cancer stem cells (BCSCs). The lysates were used to incubate with monocyte-derived immature DCs. To track the transfection efficiency, the BCSCs were stably transfected with green fluorescent protein (GFP). The maturation of DCs was evaluated by expression of costimulatory molecules including CD40, CD80, and CD86. Transfections were confirmed by evaluating GFP expression in DCs at 24 hours post transfection. Results: The results of this study showed that GFP is expressed in DCs after both total RNA and lysate incubation. The expression of costimulatory molecules (CD40, CD80, and CD86) was significantly higher in RNA-transfected DCs than  in cell lysate-primed DCs. Conclusion: Our findings suggest that total RNA primed BCSCs can be a suitable platform for DC-based vaccine therapy of breast cancer.
      PubDate: 2016-07-01
      Issue No: Vol. 3, No. 6 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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