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Journal of Biomedical and Pharmaceutical Research
Number of Followers: 2  

  This is an Open Access Journal Open Access journal
ISSN (Print) 2279-0594
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  • Microstylis muscifera (Jeevak): Highly Therapeutic and Endangered Orchid

    • Authors: Richa Raturi, Gunpreet Kaur, Vikas Gupta, Mukesh Maithani, RG Singhal, Parveen Bansal
      Abstract: In ancient times, Ashwani Kumars (Ayurvedic wonder healers) have been said to see the old, frail and emaciated body of Rishi Chyawan and decided to rejuvenate his body through medication by incorporating Ashtawarga, a group of eight medicinal plants in a “Leham” (a semi solid formulation) and did the miracle of rejuvenating the body of Rishi Chyawan as youthful. Since then after the name of Rishi Chyawan, the preparation was called as Chyawanprash and has been a favorite and most demanded medicine for Kings and rich people. Microstylis muscifera is one of the important plants of Ashtawarga group. Department of AYUSH has suggested use of substitutes in formulations in absence of original plants however this option is being exploited by manufacturers rendering this precious plant in ignored condition. Hence it becomes important to highlight the therapeutic potentials of this plant in front of scientists so that a justified research is carried out on an important but ignored plant. A limited data with scientific evidences are available in modern literature/internet sources; whereas old texts show valuable evidences in regional languages or in Sanskrit. Hence real uses of the plant are not well understood by scientific fraternity.  Purpose of this compilation is to bring all the therapeutic potentials at a single platform so as to enable scientists working on these plants to know the scientific clues available in ancient literature. The compilation reflects multiple uses of plant active components in a number of Ayurvedic formulations useful in plethora of disorders. Keywords: Jeevaka, Ashtawarga, Anti-aging, Rejuvenative
      PubDate: 2017-11-27
      Issue No: Vol. 6 (2017)

    • Authors: Versha Parcha, Dharmender K, Vibhu P, Alok M, Babita M
      Abstract: Objective: Water makes up more than two thirds of the weight of the human body. Water is important in homeostasis process to maintain the relatively constant temperatures within the body 80% of the diseases in India are water-borne. The exploration, exploitation and unscientific management of   water resources in Dehradun have posed a serious threat of reduction in usage of this supply for drinking purpose thus leading to increased consumption of packaged drinking water. Method: In present study   five brands of packaged drinking water bottles sold in the market of Dehradun city of Uttarakhand were taken and analysed for quality parameters. Physical (colour, odour, taste, temperature conductivity etc.) chemical (hardness, tds tss, total alkalinity, cod, bod etc) and microbiological characteristics (colony count) of these brands were studied and compared to Dehradun supply water on the same lines. Studies were repeated to come to concurrent conclusion. Results: Present study results showed that physical and chemical characteristics of the brands fulfill all the requirements and comply all standard values in comparison to water supply sample which was found to be unsafe for drinking purpose .Further All the brands were also tested for colony count for bacteria in bottles after 24 and 48 hrs of opening of the bottles. Conclusion: All brands of packaged drinking water bottles sold in Dehradun city of Uttarakhand are reported to be safe to use in comparison to water supply sample of the city. Keywords: Contamination, insecticides, pesticides and mineral bottled
      PubDate: 2017-11-27
      Issue No: Vol. 6 (2017)
  • In-Vitro Release Kinetics of Clonazepam from Five Brands of Clonazepam
           Available in Bangladesh Using UV Spectroscopic Analysis in Deionized Water

    • Authors: Tirtha Nandi, Md. Anisur Rahman, Rafat Shahriar Islam, Shahadat Hossen Mozumder, Kazi Shoriful Hasan, Mahbubur Rahman Bhuiyan, Omer Fayshal Pavel
      Abstract: Background and Objective: The purpose of this study was to determine the in vitro release kinetics of five brands of Clonazepam tablets available in the local pharmaceutical market of Bangladesh. Methodology: In this study, five widely prescribed brands C1, C2, C3, C4 and C5 were chosen. All of these brands were 0.5 mg Clonazepam with strip packaging. The dissolution was carried out using USP apparatus-II and the analysis was performed with the UV spectroscopy. To find out the release kinetics, K0 (for zero order), K1 (for first order), Kh (for Higuchi model) were determined. The R2 values for each kinetics were also determined which indicated the linearity of release kinetics for each brand. Result: The study found no brand to follow the zero-order and first order kinetics mostly except Higuchi’s drug release profile. The brands showing different R2 values for Higuchi Drug release profiles are C1 (R2=0.9843), C2 (R2=0.9548), C3 (R2=0.9726), C4 (R2=0.9578), C5 (R2=0.9334) which were the highest amongst the R2 values comparing to zero order and first order values. Conclusion: It is concluded that the available Clonazepam tablet brands available in Bangladesh generally follow the Higuchi’s drug release kinetics. Keyword: Clonazepam, Dissolution, release kinetics, In-vitro drug dissolution, drug release equations.
      PubDate: 2017-11-27
      Issue No: Vol. 6 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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