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Journal Cover Journal of Food and Pharmaceutical Sciences
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2089-7200 - ISSN (Online) 2339-0948
   Published by Gadjah Mada University Homepage  [4 journals]
  • Determination of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol
           Hydrochloride in 4FDC Tablet by FTIR Spectrophotometry in Combination with
           Multivariate Calibration

    • Authors: Zakiah Kurniati, Sugeng Riyanto, Abdul Abdul Rohman
      Abstract: This study was aimed to develop a fast, inexpensive, simple, and not involving hazardous reagent for the determination of rifampicin (RIF), isoniazid (INH), pyrazinamide (PZA) dan ethambutol hydrochloride (ETH) in 4FDC tablet based on infrared spectrophotometry in combination with chemometrics of partial least square (PLS) calibration. The analytical procedure involves three steps, namely calibration, validation and sample assay. The multivariate calibration model is evaluated by determining the precision and accuracy parameters, as suggested by IUPAC. The results showed that the optimized wavenumber range for the determination of RIF was the combined wavenumbers of 433 – 1552 cm-1 and 1756 – 3412 cm-1, the wavenumber of 433 – 873 cm-1 was selected for quantification of INH, 1714 – 2756 cm-1 for PZA, and 1552 – 2970 cm-1 for ETH. The predicted residual error sum of square (PRESS) values of RIF, INH, PZA and ETH contents were 0.00392%, 0.011724%, 0.007604%, and 0,003368%, respectively. The root mean square error of prediction (RMSEP) values obtained for analysis of RIF, INH, PZA and ETH were 0.01979%, 0.03424%, 0.027575% and 0.018351%, respectively. The values of coefficient of determination (R2) for the relationship between actual values of these drugs and calculated values of these drugs using FTIR spectroscopy were 0.990, 0.977, 0.992 and 0.998 for RIF, INH, PZA and ETH, respectivelty. The developed method was succesfully applied for the determination of 4FDC tablet. The contents of RIF, INH, PZA and ETB in 4FDC tablets were in agreement with those specified in monograph of Indonesian Pharmacopeia.Keywords:  infrared spectrophotometry, rifampicin, isoniazid, pyrazinamide, ethambutol hydrochloride, partial least square.
      PubDate: 2016-09-20
      Issue No: Vol. 4, No. 2 (2016)
           (Dendrophthoe pentandra (L.) Miq) FROM FALSE ASHOKE TREE

    • Authors: Aliyah - Fahmi
      Abstract: Research on  the antioxidant activity test of total flavonoids  mistletoe leaves (Dendrophthoe pentandra (L.) Miq) from false ashoke tree (Polyalthia longifolia) had been done. This study aimed to determine antioxidant activity of total flavonoids  mistletoe leaves based on reduction method of free radicals 2.2- diphenyl-1-picrylhydrazyl (DPPH) 200 ppm using a UV Visible Spectrophotometer at maximum wavelength 516 nm was obtained Inhibition Concentration (IC50) amount 6,16 mg / L with the reduction  percentage of 98.61% at 100 ppm which means it had a very strong antioxidant activity.
      Keywords: mistletoe leaves, Dendrophthoe pentandra (L.) Miq, antioxidant activity ,false ashoke tree
      PubDate: 2016-09-20
      Issue No: Vol. 4, No. 2 (2016)
  • Optimization of Self-nanoemulsifying Drug Delivery System for

    • Authors: Oktavia Eka Puspita, Suwaldi Suwaldi, Akhmad Kharis Nugroho
      Abstract: Solubility is prerequisite for drug absorption across absorptive cell lining the small intestine. It is a problem for poor water soluble drug because limiting its bioavailability when administered by oral route. Lipid based delivery system such as self-nanoemulsifying delivery system (SNEDDS) can be utilized in improving its solubility so that better bioavailability is achieved. Pterostilbene has extremely low solubility in water then become its limiting factor for the bioavailability. This research developed SNEDDS for oral delivery of pterostilbene. Optimum composition of SNEDDS formulation was judged by its dispersion efficiency and clarity when dispersed in water. The efficiency of this formula in enhancing bioavailability was assessed by in vitro digestion model to predict its bioavailability by determining its bioaccessibility. The result showed that optimum composition of SNEDDS was achieved by soybean oil-Croduret® 50-Span 80-PEG 400 in ratio of 16.37 %, 32.07 %, 11.56 %, and 40 %, respectively. This formula has bioacessibility of 91.48 ± 2.18 %, and it is much higher compared to pterostilbene that was not formulated into SNEDDS, i.e 4.63 ± 1.11 %. Determined by dynamic light scattering, this optimum formula has droplet size of 31.8 nm when dispersed in water.
      PubDate: 2016-09-20
      Issue No: Vol. 4, No. 2 (2016)
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