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  Journal of Food and Pharmaceutical Sciences
  [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2089-7200 - ISSN (Online) 2339-0948
   Published by Gadjah Mada University Homepage  [4 journals]
  • Application of chemometrics in combination with Fourier Transform Mid
           Infrared spectroscopy for authentication of avocado oil

    • Authors: Fajar A. Lumaksoa, Sugeng Riyanto, Shahrel Ahmad SA, Arieff Salleh Rosman, Farahwahida Mohd. Yusoff, Abdul Rohman
      Abstract: This recent study was carried out to develop a rapid, simple, and accurate analytical method for authenticity determination of avocado oil (AO). Fourier transform-mid infrared (FT-MIR) spectroscopy technique aided with Partial Least Square (PLS) were optimized for that purpose to binary mixtures of AO with grapeseed oil (GO) and sesame oil (SeO). The calibration models were constructed at following selected MIR region with normal spectra treatment at combination 1006-902; 1191-1091; and 1755-1654 cm-1 (GO in binary mixture with AO) and 4000-650 cm-1 for analysis of SeO in binary mixture with AO. The high value of coefficient of determination (R2) of 0.9994 with low root mean square error of calibration (RMSEC) value of 0.86 %v/v was revealed in GO quantification. Meanwhile, R2 of 0.9997 with RMSEC 0.73 %v/v were obtained for analysis of SeO in binary with AO. The given value of root mean square error of pprediction (RMSEP) during model validation were 0.52 %v/v (GO) and 0.53 %v/v (SeO), respectively. The high value of R2 and low value of RMSEC and RMSEP during calibration and validation were associated with the accuracy and precision of the used method. Keywords: avocado oil, FT-MIR spectroscopy, authentication, partial least square.
      Issue No: Vol. 3, No. 1
       
  • The use of Fourier Transform Infrared Spectroscopy (FTIR) and Gas
           Chromatography Mass Spectroscopy (GCMS) for Halal Authentication in
           Imported Chocolate with Various Variants

    • Authors: Suparman Suparman
      Abstract: The analysis using FTIR and GCMS spectrophotometry for halal authentication on several variants of imported chocolate products circulating on the market has been performed. FTIR spectra analysis result of lard and chocolate in the wave number region of 4000-650 cm-1 shows a typical lard-specific difference at wavenumber region 3006.8 cm-1; 1118.84 cm-1; 1097.42 cm-1. Analysis of PCA and PLS calibration models in the fingerprint region 999.053 - 1190.638cm-1 can be used for lard identification in chocolate fat. The relationship between the actual value and the predicted value of lard in chocolate yields the equation Y= 1,000x-0,0378, (R2 0,997 and RMSEC 1,563) with a minimum limit of detection at a concentration of 4%. Based lard chromatogram, it shows the peak appeared at a retention time of 38,8 minutes. After being compared with library WILLEY7, it shows eikosadienoat 11.14 acidic compounds. Eikosadienoat 11.14 acid is a marker of the presence of lard appearing with a mixture of lard concentration at ≥ 10%. FTIR spectra and analysis results using PCA and PLS on samples of 6 imported chocolate variants show a lard content which is marked by the appearance of eikosadienoat 11.14 acid at a retention time of 38,8 minutes in the chromatogram. PLS quantitative analysis shows lard content in the sample is 43.6%; 73.5%; 61.7%; 63.0%; 37.0%; and 30.4%.Keywords:  FTIR, GCMS, Eikosadienoat, Chocolate
      Issue No: Vol. 3, No. 1
       
  • Design and Evaluation of Gastro retentive Drug Delivery System of Anti
           Ulcer Drug

    • Authors: J S Patil
      Abstract: Floating matrix tablets of Lansoprezol were developed to prolong gastric residence time, leading to sustained action of the drug. Tablets were prepared by wet granulation technique, using hydroxypropylmethyl-cellulose as a polymer in two different grades, HPMC K4M and HPMC K15M. Tablets were evaluated for their physical characteristics, viz., hardness, thickness, friability, mass variation, drug content and floating properties. Further, tablets were studied for in vitro drug release characteristics for 24 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on in vitro characteristics and was used in vivo radiography studies by incorporating barium sulphate. These studies revealed that the tablets remained in the stomach for 12 hours in fasting rabbits and indicated that gastric retention time was increased by the floating principle, which was considered desirable for the absorption window drugs.Keywords: Lansoprezol; floating tablets; gastric residence time; gastroretentive drug delivery system
      Issue No: Vol. 3, No. 1
       
 
 
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