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Journal Cover Journal of Food and Pharmaceutical Sciences
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2089-7200 - ISSN (Online) 2339-0948
   Published by Gadjah Mada University Homepage  [4 journals]
  • Investigation of Effect of Extensively Used Polymers on Thermoreversible
           Properties of Pluronic ® Tri-Block Polymer

    • Authors: Nilesh Ramesh Rarokar, Suprit D Saoji1, Pramod Khedekar
      Pages: 24 - 34
      Abstract: This investigation presents a study on the effect of various polymers on gelling properties of tri-block (Pluronic®) copolymers and increasing the stability parameter of in situ gelling system by altering their composition. The tri-block copolymers finds their importance in fabrication of in situ gelling system for the delivery of various kinds of drugs, which can be administered by topical, ophthalmic or parenteral routes. Pluronic®, is a category of non-toxic, water soluble, biodegradable poly (ethylene oxide)/poly (propylene oxide)/poly ethylene oxide), tri-block copolymers which have application in formulation of various in situ gelling systems. This formulation undergo thermo-reversible gelation, where it exists as a free flowing liquid at low temperature and gels in the range of body temperature to form stable depot in aqueous environment. Gelling system was prepared according to the 'Cold Method' using different concentration of polymers (15% to 20% w/v) and subjected to the determination of gelation temperature (GT), viscosity study and effect of various polymers on the strength of gelation. Overall study on the gelation of system at particular temperature is the important parameter for formulation of in situ drug delivery system. It was established that addition of 0.5% w/v of HPMC K4M into gelling system make it stable for forming gel in the range of body temperature whereas methyl cellulose, carbopol 934P, and HPMC E-5 restrict the gel formation. Key words: Tri-Block Copolymer; Gelation Temperature; Gelling System; Depot.
      PubDate: 2017-09-15
      DOI: 10.14499/jfps
      Issue No: Vol. 5, No. 3 (2017)
  • Biochemistry and Bioactive Compounds on Bamboo Shoots as the Main
           Component in Lumpia Semarang

    • Authors: Ainezzahira Ainezzahira, Cynthia Mudhita, Ivana Giovani, Metta Santika Buntoni, Junita Magdasari
      Pages: 25 - 28
      Abstract: Semarang style lumpia (or spring roll) is a typical culinary in Semarang city that uses bamboo shoots as filling. The objective of this study is to determine biochemical contents and bioactive compounds in bamboo shoots as the main filling component of Semarang Style Lumpia. This journal will discuss bamboo shoots in terms of the physical characteristics, chemistry, nutrition, sensory, bioactive compounds that exist in them. The result shows that bamboo shoots have physical characteristics, i.e soft texture, crunchy, and generally yellow. The chemical compositions of raw bamboo shoots per 100 grams are 2.6% of protein, 0.3% of fat, 5.2% of carbohydrate, and 91% of water. Bamboo-shoots are sources of food that have low fat but high fiber and minerals so bamboo shoot can be a source of healthy food. Bamboo shoots also contain 17 amino acids, 8 of which are essential for human body. The flavors found in bamboo shoots are influenced by total sugar content, amino acids, and tannins. In general, bamboo shoots have a spicy flavor that comes from cyanide. Bamboo-shoots contain some phytochemical groups that have roles for health, one of them is phenolic compounds. These compounds provide positive health effects such as anti-oxidants, anti-inflammatory, anti-allergy, and anti-microbial. The antioxidant type of phthiocerol on bamboo shoots can lower cholesterol and protect from free radicals. Keywords : Biochemistry, Bioactive, Characteristic, Semarang Style Lumpia, Bamboo Shoots.
      PubDate: 2017-11-21
      DOI: 10.14499/jfps
      Issue No: Vol. 5, No. 3 (2017)
  • Piptadenia Africana: Enhances Weight Gain, Oxidative Stress,
           Hyperlipidemia in Normal and Hypercholesterolemic Male Wistar Rat

    • Authors: Nwozo Sarah Onyenibe, Oyinloye Babatunji Emmanuel
      Pages: 35 - 39
      Abstract: Poyphenol rich stem bark of Piptadenia africana (PA) is used to treat gastric pain, fever, cough and we evaluated the effect of daily, continual intake of PA for eight weeks in hypercholesterolemic rats. Thirty six rats were divided into six equal groups, A (positive-control); B (cholesterol) (negative-control); C (100 mg/kg bwt PA); D (200 mg/kg bwt PA); E (cholesterol+100 mg/kg bwt PA) and F (cholesterol+200 mg/kg bwt PA). Corn oil served as vehicle for both cholesterol (40 mg/kg/0.3ml) and PA. PA caused increased weight-gain, no enlarged organs but decreased their protein concentrations relative to control. Serum triglyceride, total cholesterol and LDL-cholesterol were elevated in PA only and PA co-treated cholesterol rats relative to both control groups, culminating in high atherogenic index. Lipidperoxidation increased dose dependently while glutathione-peroxidase, glutathione-S-transferase, reduced glutathione, superoxide dismutase and catalase decreased in PA treated groups relative to controls. Histological examination revealed necrosis of hepatocytes in groups D and moderate coagulation of necrosis of tubules of renal medulla in C. Continuous usage of PA may not be totally safe as it enhances weight gain, unhealthy lipid profile, increase chances of cardiovascular disease, elicits oxidative stress and induces organ toxicity. Key words: atherogenic-index, lipidperoxidation, lipid profile, organ toxicity, Piptadenia africana.
      PubDate: 2017-10-12
      DOI: 10.14499/jfps
      Issue No: Vol. 5, No. 3 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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