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Journal Cover   Journal of Excipients and Food Chemicals
  [SJR: 0.395]   [H-I: 6]   [2 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 21502668
   Published by International Pharmaceutical Excipients Council Homepage  [1 journal]
  • Effect of thermal and chemical modifications of excipients on the
           compressional properties of paracetamol tablet formulations containing
           Corn, Cassava and Sweet Potato starches as filler-binders

    • Authors: Mariam V Lawal, Michael A Odeniyi, Oludele A Itiola
      Abstract: The effects of thermal and chemical modifications of cassava and sweet potato starches on the properties of directly compressed paracetamol tablets in comparison with official corn starch were determined. Fresh tubers of cassava plant, Manihot esculenta Crantz (family Euphorbiaceae), and sweet potato plant Ipomoea batatas L. Lam (family Convolvulaceae) were sourced and the natural, acetylated and pregelatinised forms of the botanical starches were prepared with Corn starch BP as the standard.  Paracetamol tablet formulations (500mg) were prepared by direct compression using the starches at various concentrations. The compressional properties of the tablets were evaluated using Heckel, Kawakita and Gurnham equations. Modification of the starches produced a reduction in Pk (an inverse measure of plasticity) values in the paracetamol formulations at low starch concentrations (10.0% to 25.0%), indicating an increase in the total amount of plastic flow. The Pk values increased with starch modification at higher starch concentrations (≥ 50.0%). Tablets containing corn starch showed higher c values of the Gurnham equation suggesting greater densification. Thermal and chemical modification of the experimental starches improved the compressional properties of directly compressed paracetamol tablet formulations, and thus they can be developed for use as pharmaceutical excipients.
      PubDate: 2015-09-27
      Issue No: Vol. 6 (2015)
  • Development of Cracks on Delayed Release Film of Hygroscopic Cores: A
           Review of the Tablet and Coating Formulations, Coating Process and Storage

    • Authors: Manjurul Kader
      Abstract: An Aqueous dispersion of methacrylic acid copolymer NF is extensively used for delayed release coating in the pharmaceutical industry. However, one of the concerns is the developments of cracks on the coating film of hygroscopic tablet. The cracks on the film develop during storage. The film formed using methacrylic acid copolymer NF dispersion is inherently brittle. Therefore, the film cracks during storage especially when exposed to elevated heat and humidity. In general, the film cracks due to the mechanical stress during the coating process or by stretching effects in tablets after the coating process. The important factors to maintain the integrity of the coating film are: formulation of the core tablet and its hardness, formulation of the coating dispersion and coating process parameters. Core tablet hardness, its relaxation property, water content and content of the insoluble components in the coating formulation, temperature and relative humidity (RH) of the inlet air influence the film quality and integrity. in this paper, the probable reasons for the development of crack on the film of the hygroscopic core are discussed with reference to the properties of the core tablet, coating formulation (e.g., polymer, plasticizer, and insoluble excipients) and the coating process parameters.
      PubDate: 2015-09-27
      Issue No: Vol. 6 (2015)
  • Recent Confusion and Ongoing Actions related to the FDA's Inactive
           Ingredient Database (IID) - What should I include in my ANDA'

    • Authors: David R Schoneker
      PubDate: 2015-09-27
      Issue No: Vol. 6 (2015)
  • The changes at the USP

    • Authors: Richard Christian Moreton
      PubDate: 2015-09-27
      Issue No: Vol. 6 (2015)
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