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Journal Cover Journal of Excipients and Food Chemicals
  [SJR: 0.395]   [H-I: 6]   [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 21502668
   Published by International Pharmaceutical Excipients Council Homepage  [1 journal]
  • Macromolecular excipients exert biological effects via their microbial
           fermentation absorbable products

    • Authors: Shireesh Apte
      Pages: 1 - 3
      Abstract: No abstract
      PubDate: 2016-03-24
      Issue No: Vol. 7, No. 1 (2016)
       
  • Impact of degree of substitution of acetylated Ofada rice starch polymer
           on the release properties of nimesulide microspheres

    • Authors: Adenike Okunlola, Temitope Owojori
      Pages: 4 - 16
      Abstract: Nimesulide microspheres were prepared by the quasi-emulsion solvent diffusion method, using acetylated starches of the indigenous Ofada rice (Oryza glaberrima Steud) with degrees of substitution (DS) 1.42 and 2.62. Full 23 factorial experimental design was performed using DS (X1), drug: polymer ratio (X2) and polymer concentration (X3) as independent factors; size, entrapment, swelling and time taken for 80% drug release (t80) were the dependent variables.Contour plots were generated and data from in vitro release studies were fitted to various kinetic models. Nimesulide microspheres were near -spherical, with size 50.91±16.22 to 74.24±24.73 µm for microspheres containing starch DS 1.42 and 21.05±4.25 to 46.10±3.85 µm for starch DS 2.62. Drug entrapment was 56.75±0.45 to 98.28±2.30 %. DS had the most influence on size, swelling and dissolution time (p = 0.01) and this was confirmed from the contour plots. The interaction between factors DS and drug: polymer ratio (X1X2) had the highest influence on microsphere properties (p = 0.04). Drug release fitted into first order, Higuchi and Korsmeyer models.  Acetylated starch of Ofada rice DS 2.62 was found more suitable for the formulation of microspheres with reduced size, and swelling, higher entrapment and prolonged drug release. 
      PubDate: 2016-03-24
      Issue No: Vol. 7, No. 1 (2016)
       
 
 
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