Indonesia Journal of Biomedical Science
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Open Access journal
ISSN (Print) 2085-4773 - ISSN (Online) 2302-2906
Published by Udayana University [1 journal]
- ANTI-HIPERCHOLESTEROLEMIA OF ANREDERA CORDIFOLIA IN HYPERCHOLESTEROLEMIA
RAT WISTAR THROUGH DECREASE OF MALONDIALDEHYDE AND 8-HYDROXY-DIGUANOSINE
Authors: S. Wahjuni
Abstract: High cholesterol diet leads to increase of plasma cholesterol and subsequently will end up with hypercholesterolemia. Ignorance of healthy food and lacks of activity are the trend of modern life style. These conditions exacerbated the incidence of hypercholesterolemia in either developed or developing countries. This research aims to determine potential of anredera cordifolia leafs extracts as an anti-hypercholesterolemia by lowering of malondialdehyde (MDA) and 8-hydroxy-diguanosine (8-OHdG) blood levels in hypercholesterolemia Wistar Rat. This is an experimental study applied post only control group design. A number of 15 male wistar rats were used in this study. Rats were randomly divided into 3 groups, i.e. negative control group (C1), positive control group (C2) and anredera cordifolia leaf extract at dose of 100 mg/kg BW group (T). MDA was determined based on malondialdehyde assay (NWLSSTM). 8-OHdG was determined based on oxidative DNA Damage (Cell Biolabs, Inc). The mean difference between control and treatment was assessed by applying ANOVA and consider significant at p < 0.05. In this study, we observed that there were a significant of MDA and 8-OHdG levels between group C1 and T; C2 and T within p < 0.05. This result indicates anredera cordifolia leafs extract has an ability to inhibit hypercholesterolemia in wistar rat fed with high cholesterol diet.
Issue No: Vol. 8 (2014)
- THE INCREASED INCIDENCE OF NAUSEA AND VOMITING DUE TO ANXIETY IN
PACLITAXEL CARBOPLATIN CHEMOTHERAPY IN A 48 YEARS OLD FEMALE PATIENT WITH
CERVICAL CANCER: A Case Report
Authors: I. F. W. Putra, R. Noviyani, and; K. Suwiyoga
Abstract: Nausea and vomiting was the frequently side effects in chemotherapy.Uncontrolled nausea and vomiting can cause weakened body condition, reduced appetite and drinking, dehydration, electrolyte disturbances, reduced nutritional status so the patient refused to undergo further chemotherapy. Anxiety is one of the factors that increase the risk of nausea and vomiting. We reported the case of the woman 48 years old, height 150 cm, weight 51 kg, occupation housewife, diagnosed non-keratinizing squamous cell carcinoma cervical cancer stage-IIB and received paclitaxel carboplatin for three cycles of chemotherapy. She experienced anxiety, acute nausea vomiting on the third cycle of chemotherapy and delayed nausea and vomiting of the three cycles of chemotherapy.
Issue No: Vol. 8 (2014)