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Journal Cover European Thyroid Journal
   Full-text available via subscription Subscription journal
     ISSN (Print) 2235-0640 - ISSN (Online) 2235-0802
     Published by Karger Homepage  [104 journals]
  • Industry-Sponsored Satellite Symposia
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):227–241
  • Abstracts
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):73–226
  • A Warm Welcome to the ETA Annual Meeting in the Wonderful City of Santiago
           de Compostela
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):V–VI
  • General Information
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):242–248
  • Scientific Programme
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):1–72
  • Title Page / Table of Contents / Scientific and Organizing Committees
    • Abstract:
      Eur Thyroid J 2014;3(suppl 1):I–IV
  • Small Lymphocytic Lymphoma of the Thyroid Mimicking Plasmacytoma
    • Abstract: Primary thyroid gland lymphomas (PTLs) typically occur in middle- to older-aged individuals in the setting of lymphocytic thyroiditis with a predilection for females. Diffuse large B-cell lymphoma is the most frequent histologic subtype of thyroid lymphomas. Small lymphocytic lymphoma (SLL) belongs to the least common subtypes of thyroid lymphoma. It is often associated with the involvement of lymph nodes, bone marrow, spleen, liver and, extremely rarely, other organs. PTLs with plasmacytic differentiation or extensive infiltration by plasma cells have been observed in marginal zone B-cell lymphomas in the thyroid but have never been described in a setting of SLL. Here, we present a case of primary SLL of the thyroid mimicking extramedullary plasmacytoma on fine-needle aspiration cytology. © 2014 European Thyroid Association Published by S. Karger AG, Basel
      Eur Thyroid J
  • Myasthenic Crisis Manifesting as Postoperative Respiratory Failure
           following Resection of Unsuspected Intrathoracic Thymic T-Cell Lymphoma
           during Thyroidectomy for an Adjacent Large Retrosternal Goiter
    • Abstract: A middle-aged female with a goiter of 10 years' duration presented with progressive pressure symptoms, nocturnal choking and dyspnea on exertion for 5 months. Physical examination demonstrated a large simple multinodular goiter. Imaging revealed a deep retrosternal goiter extending below the tracheal bifurcation with marked tracheal deviation. Total thyroidectomy was carried out via a cervical approach and a median sternotomy. Extubation was not possible, and the patient had to be kept intubated. She then went into a myasthenic crisis. Initial ventilatory support was followed by intravenous immunoglobulin, steroids and pyridostigmine. The patient had complete remission and was asymptomatic 18 months later. Histopathology showed a T-cell-rich thymoma in addition to a nodular colloid goiter. © 2014 European Thyroid Association Published by S. Karger AG, Basel
      Eur Thyroid J
  • Iodophilic Synchronous Phalangeal and Choroidal Metastasis from Follicular
           Thyroid Carcinoma: A Case Report and Review
    • Abstract: Background: Follicular thyroid cancers constitute 15-20% of all thyroid tumors. The usual mode of dissemination is via the hematogenous route. The most common sites of distant metastasis are to the lungs and bones. Objective: A case is presented to demonstrate the unusual presentation of follicular cancer with synchronous digital (distal phalanx of the little finger) and choroidal metastasis that was responsive to radioiodine treatment. Case Report: A 54-year-old female presented with swelling over the terminal part of the left little finger with thyromegaly. Investigations revealed metastasis from follicular thyroid cancer to the little finger along with pulmonary metastases. She underwent total thyroidectomy with central compartment clearance followed by 131I therapy. Subsequent follow-up demonstrated complete regression of the digital metastasis and partial regression of the choroidal metastasis which was evaluated after the radioiodine scan that picked up the choroidal metastasis. Conclusion: Follicular thyroid cancers can rarely spread to unusual sites like the digits and choroid. This report highlights the synchronous presentation of digital and choroidal metastasis which responded to 131I therapy. © 2014 European Thyroid Association Published by S. Karger AG, Basel
      Eur Thyroid J 2014;3:134-136
  • Development and Application of a Novel Sensitive Immunometric Assay for
           Calcitonin in a Large Cohort of Patients with Medullary and Differentiated
           Thyroid Cancer, Thyroid Nodules, and Autoimmune Thyroid Diseases
    • Abstract: Background: Serum calcitonin (sCT) is a useful biomarker for medullary thyroid cancer (MTC). Consensus has not been reached concerning sCT measurements in the evaluation of nodular thyroid disease (NTD). Objective and Methods: We developed a new immunofluorometric assay for sCT and have validated it in samples from 794 patients [203 with MTC, 205 with autoimmune thyroid disease (ATD), 248 with NTD, 80 with differentiated thyroid cancer (DTC) ‘free of disease', 58 with chronic renal failure (CRF)] and 178 normal individuals, including samples after pentagastrin tests and samples from the washout of 92 FNA procedures in patients with NTD or MTC. We also compared some samples from patients with low or high calcitonin levels using both this assay and the Nichols Institute Diagnostics (NID) assay. Results: The assay's analytical sensitivity was 1.0 pg/ml. Considering MTC patients prior to surgery, the cut-off values for the 95% reference range were 11.1 pg/ml for males and 5.5 pg/ml for females and employing the ROC curve were 18.4 pg/ml for males and 7.8 pg/ml for females. sCT in patients with MTC was strongly correlated with disease status. Patients with NTD and ATD did not present false-positive results. sCT measurements were significantly correlated with age (excluding MTC and CRF). The NID test had a strong correlation with our assay. A hook effect was observed only with concentrations >200,000 pg/ml. Conclusions: We developed a novel sCT assay and validated it in healthy subjects, as well as in a large cohort of patients with MTC, NTD, ATD, DTC, and CRF. © 2014 European Thyroid Association Published by S. Karger AG, Basel
      Eur Thyroid J 2014;3:117-124
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