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Journal Cover American Journal of Medical and Biological Research
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4080 - ISSN (Online) 2328-4099
   Published by Science and Education Publishing Homepage  [72 journals]
  • Assessing Ramus Dimorphism of Jordanian Mandibles

    • Authors: Wala M Amin
      Pages: 1 - 6
      Abstract: This investigation deals with descriptively examining the mandibular rami of young Jordanian adults for the presence or the lack of it of a flexure at the posterior border of a ramus; and evaluating the role of ramus flexure in sex identification. Three-dimensional (3D) rendered Cone Beam Computed Tomography (CBCT) images of a normative sample comprising 270 images were selected, of which 147 belonged to male patients and 123 images to females. Strict exclusion criteria were applied in selecting images. Each image was examined for the presence of a flexure on the posterior border of the ramus, which was carefully delineated and the occlusal plane marked, guided by the height of cusp tips of the mandibular molars. The results indicated that the ramus flexure method of sex prediction was more accurately diagnostic for females (85.1%), than for males (78.9%); this gave rise to an overall diagnostic accuracy of 82.2% which is below the reported 90.6-99.0% by Loth & Henneberg. Our results, however, agreed with the reported findings of other researchers. In conclusion, ramus flexure provides an acceptable predictive accuracy and could be considered as a supplementary rather than a definitive mean of sex determination.
      PubDate: 2018-2-8
      Issue No: Vol. 6, No. 1 (2018)
       
  • The Relationship between Total Ige and Neutrophils Count with Degrees of
           Asthma Control in Adult Atopic Patients

    • Authors: Eko E Surachmanto; Mochammad Hatta, Andi Asadul Islam, Syarifuddin Wahid
      Pages: 7 - 10
      Abstract: Introduction: Asthma is a chronic reversible inflammation which is caused by bronchial hypereactivity due to exposure to allergen and hyperproduction of certain specific IgE. Neutrophil in respiratory tract and high level of IgE in the blood serum is known to play in complex mechanism in asthma development. The role of total IgE serum and neutrophil serum in asthma development is still not well known. Aim: This study aim is to assess the correlation between level of total IgE and neutrophil serum with degree of asthma control. Methods: This is a cross sectional study with 35 adult subjects with atophy asthma (age 22-61), all of participant reside in Manado and its surrounding area. Degree of asthma control is categorized as intermittent, mild persistent, moderate persistent and severe persistent based on criteria by GINA. Patient with malignancy, sepsis, lung tuberculosis, diabetes mellitus, pregnant, and late stage chronic kidney disease are excluded from this study. Result: In this study there is no significant correlation between total IgE serum level and degree of asthma control (p>0.05.) also there is no significant correlation between each total IgE level and each degree of asthma control. There is significant positive correlation between neutrophil count and degree of asthma control (r = 0.309; p
      PubDate: 2018-3-16
      Issue No: Vol. 6, No. 1 (2018)
       
  • Oxidative Stress Therapy for Cancer Using Glycolysis Inhibitors: Towards
           Improving Therapeutic Outcomes

    • Authors: Salah Mohamed El Sayed
      Pages: 11 - 15
      Abstract: Cancer cure is still a big challenge despite intensive conventional treatment. Unfortunately, many unsolved problems e.g. metastasis and drug resistance still exist. Better understanding of cancer biology to identify important differences between cancer cells and normal cells seems vital to improve cancer treatment. Tumors depend on glycolysis for energy production, exhibit Warburg effect, establish aggressive microenvironment, have low antioxidant systems and are under high steady-state ROS conditions. Normal cells differ in all of that. Lactate produced through Warburg effect maintains the high steady-state ROS condition in cancer cells and helps cancer cells to metastasize and establish their hostile microenvironment. Cancer cells seem sensitive to oxidative stress therapy using ROS generating chemotherapy e.g. 3-bromopyruvate (3BP). 3BP is a powerful antiglycolytic that may be more promising as a potent anticancer if it is conjugated with polyethylene glycol (PEG). Targeting glycolysis in cancer cells seems promising in decreasing their survival and metastasis. Glycolysis double inhibition by combination of multiple antiglycolytics e.g. 3BP with citrate was synergistic in cancer treatment. Being analog to pyruvate and lactate, 3BP antagonized Warburg effect, antagonized effects of pyruvate and lactate, improved sensitivity of chemoresistant cancer cells and targeted cancer cell survival, migration and metastasis. In this review, I discuss 3BP-induced oxidative stress and ATP depletion as a promising treatment modality for cancer.
      PubDate: 2018-3-21
      Issue No: Vol. 6, No. 1 (2018)
       
 
 
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