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Journal Cover American Journal of Medical and Biological Research
  [6 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4080 - ISSN (Online) 2328-4099
   Published by Science and Education Publishing Homepage  [72 journals]
  • The Analysis of Prostaglandin E2 (PGE2), Pain Pressure Threshold (PPT),
           and Critical-Care Pain Observation Tools (CPOT) of Systemic Inflammatory
           Responses Syndrome (SIRS) Patients in Intensive Care Unit

    • Authors: Dwi Pantja Wibowo; Suryani As’ad, Fransiscus Suhadi, I Wayan Suranadi, Ilhamjaya Patellongi, Irawan Yusuf, Mohammad Ramli Ahmad, Syafrie Kamsul Arif, Andi Husni Tanra
      Pages: 13 - 17
      Abstract: Sepsis is one of the major health problems with very high costs, a number of patients who survived sepsis developed long-term complications such as persistent pain. Studies found correlation of persistent pain and PGE2 level. Aims of this study were to investigate the changes in the prostaglandin E2 levels from patients with systemic inflammatory responses syndrome (SIRS) that affect pain intensity changes with the marked increase of critical-care pain observation tools (CPOT) and decreased of the pain pressure threshold (PPT). A cross-sectional analysis to compare the values of PGE2, CPOT, and PGE2 of SIRS patients and patients without SIRS. Of the 46 patients who were the subjects of the study, there were 21 SIRS patients and 25 patients, not SIRS. Patients with SIRS had higher CPOT values and PGE2 levels than patients without SIRS; CPOT values (3.3 vs. 1.2)) and PGE2 levels (6195.81 vs. 2728.67). The PPT scores of patients with SIRS were lower than those without SIRS (4.24 vs. 7.37). The CPOT was significantly correlated (p
      PubDate: 2017-7-20
      DOI: 10.12691/ajmbr-5-2-1
      Issue No: Vol. 5, No. 2 (2017)
  • Downregulation of MMP-9 Level and GCS Score Improvement in Severe
           Traumatic Brain Injury Due to the Mild Hypothermia Therapy

    • Authors: Eko Prasetyo; Andi Asadul Islam, Mochammad Hatta, Djoko Widodo, Ilhamjaya Pattelongi
      Pages: 18 - 22
      Abstract: We recently investigated the effect of the mild hypothermia therapy towards alteration of matrix metalloproteinase-9 (MMP-9) and outcome of severe traumatic brain injury (TBI). The neurologic outcome was assessed by applying with GCS (Glasgow Coma Scale) score. Twenty patients with severe TBI whose the GCS score ≤ 8 between June 2015 and June 2016 were enrolled in RD Kandou Hospital, Manado, Indonesia. Patients were randomized into two groups, with and without the mild hypothermia therapy (34-36°C) which was investigated within 24 and 72 h. The MMP-9 level was estimated using enzyme-linked immunosorbent assay (ELISA). The assessments of outcomes were determined using the GCS score within 24 and 72 h during the mild hypothermia therapy. Our results showed that the level of serum MMP-9 was decreased significantly within 72 h in the mild hypothermia therapy group. The effects of the mild hypothermia therapy toward to the GCS score alteration were noticeable increased and differences were significant in the two groups within 72 h. We concluded that the mild hypothermia therapy diminished MMP-9 protein level and improvement of the GCS score in severe TBI patients within 72 h.
      PubDate: 2017-9-9
      DOI: 10.12691/ajmbr-5-2-2
      Issue No: Vol. 5, No. 2 (2017)
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