for Journals by Title or ISSN
for Articles by Keywords
Followed Journals
Journal you Follow: 0
Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Jurnals are published.
Already have an account? Sign In to see the journals you follow.
American Journal of Pharmacological Sciences
   Journal TOC RSS feeds Export to Zotero [3 followers]  Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
     Published by Science and Education Publishing Homepage  [19 journals]
  • Renal Effect of Lopinavir/Ritonavir and Sulfamethoxazole/Trimethoprim in
           Albino Rats

    • Authors: Adikwu Elias; Oru-Bo Precious Geoffrey, Deo Oputiri
      Pages: 77 - 81
      Abstract: Lopinavir/ritonavir and sulfamethoxazole/ trimethoprim have been individually associated with renal adverse events which could be characterized by electrolyte imbalance. The concurrent use of these drugs in the management of HIV and co infections may impair renal function; therefore this work evaluates the renal effect of the co administration of these drugs in rats. Seventy five (75) animals which were divided into five (5) groups were used in this study. Group A which served as control contained fifteen (15) animals which were treated with 1% ethanol orally. Group B-E which contained fifteen (15) animals each was further subdivided into three (3) subgroups of five (5) animals each. Animals in these groups were treated with oral doses of SMX/TMP (11.2/2.3mg/kg), LPV/r (11.4/2.9mg/kg) and combined doses of SMX/TMP + LPV/r for 2-8 weeks respectively. Serum levels of potassium, sodium and chloride were evaluated. Kidney tissues were evaluated for catalase (CAT), glutathione peroxidase (GSHPX) and histopathological changes. Results showed that treatment with LPV/r, SMX/TMP and co administered SMX/TMP + LPV/r had no significant time dependent effect on serum potassium, sodium and chloride. Treatment with SMX/TMP produced time dependent decrease in kidney CAT and GSHPX while LPV/r had no significant effect on kidney CAT and GSHPX. No significant synergistic effects were observed on CAT and GSHPX level when these agents were co administered. Single and combined doses of these agents did not produce morphological changes in the kidney of treated animals. Conclusion: Concurrent use of LPV/r and SMX/TMP in the management of a HIV and co infection may not have deleterious effect on serum electrolytes and kidney structure.
      PubDate: 2014-09-17
      Issue No: Vol. 2, No. 5 (2014)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2014