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Journal Cover American Journal of Pharmacological Sciences
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • In-silico Designing and Docking of Novel N’-(Substituted
           2-Chlorophenyl)-2-(1, 3-benzodioxo-5-carbylidene) Hydrazine Carboamide as
           Anticonvulsant Agent

    • Authors: Ajeet; Pradeep Kumar, Nishi Gupta
      Pages: 1 - 6
      Abstract: A series of N’-(Substituted 2-Chlorophenyl)-2-(1, 3-benzodioxo-5-carbylidene) Hydrazine carboamide were designed and carried with in-silico methods keeping in view the structural requirement of pharmacophore as potent anticonvulsant agents. These agents were then screened on the basis of docking procedures and further docking analysis of novel agents has been performed. The docking analysis reveals that compounds IPSR2, IPSR3, IPSR6 and IPSR9 perfectly docked with the T-type calcium channel with the highest bonding affinity range (-7 Kcal/mol to -7.5 Kcal/mol) and hydrogen bonds (5 to 7). Compounds IPSR4, IPSR5, IPSR7 and IPSR8 are found to dock with Na-channel with the bonding affinity range (-7.5 Kcal/mol to -8.3 Kcal/mol) and hydrogen bond (4 to 6). IPSR10 is found to dock with Glutamate receptor with significant bonding affinity and hydrogen bonds.
      PubDate: 2016-1-5
      Issue No: Vol. 4, No. 1 (2016)
  • Screening of Medicinal Plants Native To Kano and Jigawa States of Northern
           Nigeria, Using Artemia Cysts (Brine Shrimp Test)

    • Authors: O. A. ADOUM
      Pages: 7 - 10
      Abstract: Eleven plant species belonging to 9 families were selected in this study on the basis of their uses in Hausa folk medicine. Extracts prepared from the plans were solvent partitioned and screened for activity in the brine shrimp (Artemia cysts) lethality test (BST). All the leaves extracts of Cassia singueana exhibited very high toxicity in brine shrimp test (BST) at LC50 values less than 11µg/ml. Some extracts of Commiphra kerstingi, Jatropha curcas, Erythrina senegalensi s and Securidaca longepedunculata have showed remarkable toxicity in BST at LC50 values range between 4.5 - 367 µg/ml . Only Diospyros mespiliformis (Ebenaceae) showed very low brine shrimp lethality at LC50> 1000 µg/ml. The lethal concentration (LC50) were determined at 95% confidence intervals by analyzing the data on a computer loaded with "Finney Programme."
      PubDate: 2016-1-18
      Issue No: Vol. 4, No. 1 (2016)
  • Availability of Essential Medicines across Levels of Care in Gulu
           District, Northern Uganda

    • Authors: David Musoke; Morten Sodemann
      Pages: 11 - 14
      Abstract: The constant availability of essential and vital medicines at public health facilities is important for credible health services and the need to meet the health requirement of the community. This study assessed the availability of vital and essential medicines at selected Health Centers II, III and IV in Gulu district. We conducted a longitudinal survey which investigated the availability of vital and essential medicines at randomly selected public health facilities at the level of Health Centre II, III and IV, over a period of six months in Gulu district. The assessment was carried out on a monthly basis. The assessment of the availability of the medicines was carried out using the check lists that were derived from the Essential Medicines and Health Supplies List of Uganda as defined by the Ministry of Health of Uganda for the various levels of care. Seventeen (17) Health Centre level II, four (4) level III and two (2) level IV were included in the survey. The mean availability of medicines at Health Centre level II was 46.1% (range: 42.7- 51.0%); 48.3% (range 47.2- 57.2%) at level III and 48.0% (range 44.4- 51.6%) at the level IV respectively. The results of this study demonstrate a poor availability of essential medicines across the levels of primary health care.
      PubDate: 2016-1-22
      Issue No: Vol. 4, No. 1 (2016)
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