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Journal Cover American Journal of Pharmacological Sciences
  [2 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Antipyretic and Antianemic Activities of Three Anti-malaria Recipes from
           South Benin on Wistar Rats

    • Authors: Seindé Espérance MEDOATINSA; Cokou Pascal AGBANGNAN DOSSA, Sossa Pascal ATCHADE, Gbèdossou Sophie Reine BOGNINOU, Kossivi DOSSEH, Tchazou KPATCHA, Amegnona AGBONON, Hyacinthe AHISSOU, Dominique SOHOUNHLOUE
      Pages: 57 - 62
      Abstract: The present study aims to evaluate "in vivo" the acute toxicity, antipyretic and antianemic activities of three plant recipes used in the treatment of malaria in southern Benin lake cities on Wistar rats. We note the presence of saponosides, phenolic compounds, sterols and terpenes in the recipes studied. The toxicity evaluation of the extracts revealed that they are practically non-toxic (LD50> 5g/kg body weight) according to the Hodge and Sterner classification. All the extracts investigated contain antipyretic molecules but only two extracts (aqueous extract obtain by decoction of the child's recipe: 36.07 ± 0.48°C, hydroethanolic macerated of the adult’s recipe: 36.07 ± 0.33°C) showed significant antipyretic activity, similar to that of aspirin (36.03 ± 0.25°C) used as reference molecule in the present study. After evaluating the antianemic activity, we note that the extracts are not hemolytic.
      PubDate: 2017-10-25
      Issue No: Vol. 5, No. 3 (2017)
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