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American Journal of Pharmacological Sciences
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  This is an Open Access Journal Open Access journal
     ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
     Published by Science and Education Publishing Homepage  [19 journals]
  • Silibinin Improves the Anti-arthritic Activity of Methotrexate in
           Zymosan-Induced Arthritis in Rats

    • Authors: Ahmed Hashem Mortada; Saad Abdulrahman Hussain
      Pages: 47 - 51
      Abstract: Because of low toxic effects of plant-derived drugs, it has become a research focus in disease prevention and treatment, especially those chronic diseases requiring long-term treatment. The present study was designed to evaluate the effects of silibinin (SIL) when administered with methotrexate (MTX) in animal model of zymosan-induced arthritis in rats. Male Wistar rats are used for induction and arthritic inflammation in the knee joint and hind paw using zymosan. The animals are treated with MTX alone (10 mg/kg), SIL (10mg/kg) or their combination. The effect was followed through edema formation, tissue cytokines release (IL-1β, IL-8, TNF-α) and infiltration of leukocytes in synovial fluid. The results showed that SIL has weak antiarthritic activity when used alone, and improves the antiarthitic activity of MTX when both are concomitantly administered before challenge with zymosan. In conclusion, although SIL has a relatively weak anti-arthritic activity, it strongly augments the effect of MTX in animal model of zymosan-induced arthritis.
      PubDate: 2014-05-12
      Issue No: Vol. 2, No. 3 (2014)
  • Comparative Effect of Cold Hydro Stem-Bark Extract of Erythrophleum
           Suaveolens on Gastrointestinal Muscle of Rabbit Jejunum (Oryctolagus

    • Authors: Ogundeko O Timothy; Ramyil M Seljul, Idyu C Vivian, Idyu I Isaiah
      Pages: 52 - 55
      Abstract: Detailed investigations on plant materials especially such that are already in use especially by tradio-practitionals should not be taken with levity. The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated rabbit jejunum was studied. Reference drugs (Adrenaline and Isoprenaline) were used both in the presence and absence of E. suaveolens extract. Preliminary pharmacological investigation of the extract revealed inhibitory effects. However, the relaxative effect of the extract on isolated smooth muscle was confirmed from its cumulative response on Rabbit jejunum in which there was a graded inhibition of the jejunal contraction even up to 95% - 95.5%. The result of the study therefore suggest that the extract has the potential of been develop as an anti-motility agent as a remedy for GIT system related problems.
      PubDate: 2014-06-19
      Issue No: Vol. 2, No. 3 (2014)
  • Protective Effects of Quercetin against Isoniazid and Rifampicin Induced
           Hepatotoxicity in Rats

    • Authors: Gulala Ibrahim Qader; RoshnaShawkat Aziz, ZheenAorahman Ahmed, ZanaFaeq Abdullah, Saad Abdulrahman Hussain
      Pages: 56 - 60
      Abstract: Drug-induced liver injury is a problem of increasing significance, but has been a long-standing concern in the treatment of tuberculosis (TB). The present study evaluates the possible hepatoprotective effects of Quercetin against the experimentally induced hepatotoxicity with isoniazid (INH) and rifampicin (RFP) in rats. Twenty-four rats wereallocated into 4 groups (6 rats in each group), and treated as follow: group I, received normal saline orally; group II, receivednormal saline + (INH 10mg/Kg/day and RFP 10 mg/Kg/day orally); group III, received Quercetin (300mg/kg/day) + (INH and RFP as in group II);group IV, received N-acetyl cysteine (NAC) (50 mg/Kg/day) + (INH and RFP as in group II).After 42 days, the rats were scarified; blood samples obtained for evaluation of total antioxidant status (TAS), CRP, and the activities of ALT, AST, and ALP. Liver tissue sections were prepared for histopathologicalevaluation. The results clearly demonstrate that Quercetin provides significant protection against INH and RFP-induced toxicity in liver of rats, revealed as reduction in AST and ALT activities, increase in total antioxidant capacity, and improvements histopathologicalpicture of the liver. In conclusion, orally administered Quercetin protects the liver against INH and RFP-induced hepatotoxicity in rats.
      PubDate: 2014-07-08
      Issue No: Vol. 2, No. 3 (2014)
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