for Journals by Title or ISSN
for Articles by Keywords
Followed Journals
Journal you Follow: 0
Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Journals are published.
Already have an account? Sign In to see the journals you follow.
Journal Cover American Journal of Pharmacological Sciences
  [2 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • In-silico Antimalarial Study of Monocarbonyl Curcumin Analogs and Their
           2,4-Dinitro Phenylhydrazones Using the Inhibition of Plasmepsin II as Test

    • Authors: Olatomide A. Fadare; Ezekiel O.Iwalewa, Craig A. Obafemi, Feyisola P. Olatunji
      Pages: 18 - 24
      Abstract: A well-known component of the Indian spice turmeric, curcumin, has received a lot of attention in recent years as a potential antimalarial agent but the inherent problems associated with low bioavailabilty tends to limit its applicability. The bioavailability is linked to its low solubility in water and its rapid break down in the blood plasma. In this study, we have proposed the use of synthetic analogs of curcumin and their derivatives which are expected to be less prone to degradation in the blood plasma as possible antimalarials. The binding affinity of monocarbonyl analogs of curcumin and their 2,4-dinitrophenylhydrazone derivatives for the chain A domain of plasmepsin II, one of the key enzymes involved in hemoglobin digestion in the food vacuole of the malaria parasite was determined by computational docking analysis, performed using Auto Dock Vina 1.1.2, pymol and Chem 3D ultra 12.0. The binding energies of the 20 compounds studied was compared with that of pepstatin A (a known inhibitor of plasmepsin II), curcumin and chloroquine. The 3D structure of the protein was obtained from the protein data bank (PDB ID:1M43), the compounds’ 3D structure was generated with the Chem 3D ultra 12.0 and visualization done with pymol. Out of the 20 compounds docked with plasmepsin II, 17 had binding energies higher than that of pep A (-32.6, kJ/mol) and 19 of the compounds had binding energies higher than that of curcumin (30.96, kJ/mol). The docked compounds, 5b, 6b and 7b had the highest binding energies (-44.73 kJ/mol, -42.64 kJ/mol and -41.80 kJ/mol respectively). It is expected that the compounds with binding energies higher than that of pep A may be considered for further antimalarial studies in-vitro and in-vivo.
      PubDate: 2017-5-2
      DOI: 10.12691/ajps-5-2-1
      Issue No: Vol. 5, No. 2 (2017)
  • Various Pharmacological Aspects of Cocos nucifera - A Review

    • Authors: Babita Aggarwal; H. S. Lamba, Pankaj Sharma, Ajeet
      Pages: 25 - 30
      Abstract: Plant materials, derived from thousands of plant species from lichens to towering trees, represents substantial portion of the global market. When we think about the highly nutritious plant parts then we can’t move beyond Cocos nucifera. Many scientists around the world have worked on Cocos nucifera and revealed too may bioactivities such as antimicrobial, antiinflammatory, antiparasitic, antidiabetic, antineoplastic, insecticidal, and leishmanicidal activities. In this review also, we focused on various pharmacological aspects of Cocos nucifera, with different extraction methods and isolated compounds.
      PubDate: 2017-6-14
      DOI: 10.12691/ajps-5-2-2
      Issue No: Vol. 5, No. 2 (2017)
  • Evaluation of Self-medication Use of Antibiotics within Lebanese
           Population: A Prospective Pilot Study

    • Authors: Malak Khalifeh; Nicholas Moore, Pascale Salameh
      Pages: 31 - 39
      Abstract: Objective: The aim of this study was to assess the appropriateness of antibiotic used in community based pharmacy setting. Method: It is a cross sectional prospective study in a community-based pharmacy setting in Lebanon. It uses a structured random interview to patients visiting a community pharmacy and seeking for antibiotics. Baseline characteristics and reason for self-medication were collected. Completing the questionnaire after 30 days provided information on adherence and usage pattern. Data were analyzed using descriptive statistics and Chi-square test. A multivariate logistic regression was performed to predict factors affecting appropriateness. Results: 62.7% of 501 participants bought antibiotics without prescription. Amoxicillin/clavulanic acid was the most used antibiotic as self-medication (33.7%). 62.4% of patients used the right antibiotic and 80.1% used it in correct dosage. The duration of treatment was inappropriate in the majority of cases (68.6%). When all of these three factors were summed together, it turned out that 83.6% of antibiotics were utilized inappropriately. Appropriateness in use was seen in 27.6% and 16.4% of the prescribed and non-prescribed antibiotics respectively. Conclusion: Our study shows great misuse of antibiotics and hence there is a need to increase awareness of the health risks related to inappropriate and uncontrolled use of antibiotics.
      PubDate: 2017-6-29
      Issue No: Vol. 5, No. 2 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
Home (Search)
Subjects A-Z
Publishers A-Z
Your IP address:
About JournalTOCs
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2016