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Journal Cover   American Journal of Pharmacological Sciences
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Efficacy and Safety of Methoxy Polyethylene Glycol Epoetin - Beta versus
           Epoetin Alpha for Treatment of Chronic Renal Anemia in Hemodialysis

    • Authors: Abeer K. Jumaa; Hassan M. Abbas Al Temimi, May S. Alsabbagh, Jawad I.Rasheed
      Pages: 87 - 93
      Abstract: Objective: Chronic kidney disease is a common health problem in the world and anemia is of its common complication. The aim of this study was to evaluate the efficacy and the safety of methoxy polyethylene glycol-epoetin beta in comparison with epoetin alfa in treating chronic renal anemia in hemodialysis patients. Methods: A single center randomized controlled open labeled clinical trial with three months duration was performed. 46 Patients with chronic renal anemia were allocated randomly to receive either methoxy polyethylene glycol-epoetin beta (100μg) every two week or epoetin alfa (4000 IU) twice weekly and were evaluated at baseline and monthly after starting their treatments for 3 months. Clinical assessment was done by measuring hemoglobin concentration, packed cell volume, reticulocyte count, iron parameter, potassium level, platelets count and monitoring of the adverse events. Results There was a statistically significant increase in haemoglobin concentration, packed cell volume, and reticulocyte count in the both groups. The rise in haematological parameters in methoxy polyethylene glycol-epoetin beta group was non significantly higher than that of epoetin alfa groups. Non- significant changes were observed in potassium level and platelets count between the two groups. One case of Fistula thrombosis and local pain or tissue reaction to S.C injection was reported in methoxy polyethylene glycol epoetin beta arm. Other adverse events and complications include flu-like symptoms, diarrhea and blood transfusion was reported in both arms There were no hypertension and no death reported. Conclusion: methoxy polyethylene glycol-epoetin beta every two week effectively corrected chronic kidney disease (CKD) related anemia and was well tolerated and it is efficacy and safety is comparable to twice weekly epoetin alfa for anemia correcting in hemodialysis patients.
      PubDate: 2015-09-06
      Issue No: Vol. 3, No. 4 (2015)
  • Estimation of LD50 and Acute Toxicity of Zygophyllum fabago in Mice

    • Authors: Hasan Alhaddad; Ammar Amer Fadhil, Sajida H Ismael
      Pages: 94 - 97
      Abstract: Zygophyllum fabago, a member of the genus Zygophyllum, has lonely used in traditional medicine in Iraq for the treatment of many diseases. However, no studies have done to evaluate the acute toxicity of its extract. Thus, we designed this study to examine its acute toxicity and LD-50 value in mice depending on OECD 423 guidelines for testing of chemicals. Twenty-one mice were given Zygophyllum fabago extract in doses of 2000 or 5000 mg/kg. The results showed that both doses of Zygophyllum fabago extract did not show any toxic signs or mortality. Moreover, body weights and relative organs weight were not affected. Furthermore, it did not induce kidney and liver injuries. Therefore, results of this study suggested that Zygophyllum fabago extract is safe within the tested doses and did not produce acute toxicity when administered orally as a single dose.
      PubDate: 2015-09-23
      Issue No: Vol. 3, No. 4 (2015)
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