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Journal Cover   American Journal of Pharmacological Sciences
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Comparative Study of Propofol and Thiopentone Sodium as Intravenous
           Induction Agents in General Anaestetic Surgical Procedures in a Teaching

    • Authors: S. Vijaya; Basav Raj Munge, KK. Lakshmi Prasad, M. Prasad Naidu
      Pages: 52 - 54
      Abstract: Thiopentone and propofol are the intravenous induction anaesthetic agents used during general surgery. The study was done with an aim to compare the intra operative and the Post operative findings in Propofol and Thiopentone groups. The study was conducted in 100 adult patients of ASA grade 1 and grade II of aged between 18- 60 yrs of both sexes who were posted for different types of Surgical Procedures in department of anaesthesiology, General Hospital, RIMS, Srikakulam from January 2013 to October 2013. The intra-operative findings like Pulse rate, blood pressure and oxygen saturation were measured in both groups and no significance difference was observed for pulse rate and oxygen saturation except for Blood pressure. Post operative findings especially response time and Orientation time was less in patients receiving Propofol when compared with Thiopentone group which is highly significant. Incidence of nausea, headache and shivering were more with thiopentone sodium than with propofol. In this study we concluded that propofol is better alternative to thiopentone sodium as main anaesthetic agent for general surgical procedures with less side effects.
      PubDate: 2015-05-22
      Issue No: Vol. 3, No. 3 (2015)
  • Plants Explored with Anti-diabetic Properties: A Review

    • Authors: Om Prakash; Rajesh Kumar, Ritika Srivastava, Pragya Tripathi, Shradha Mishra, Ajeet
      Pages: 55 - 66
      Abstract: Diabetes mellitus is a chronic heterogeneous disorder; affecting the β-cells of endocrinal pancreatic gland, globally the numbers of cases of diabetes is increasing gradually. There are several medicines available in the market to treat diabetes mellitus but no drug is found to be fully effective and safe. However plants and plant-derived products have proven to be effective and safe in the treatment of various types of diabetes mellitus. In Indian system of medicine, several medicinal plants have found potential use as blood sugar lowering agents. Many of them have been scientifically explored for their usefulness in managing diabetes, the reports of which have been acknowledged and published in a number of scientific journals. At present most research work on diabetic drugs is targeted on plants and plants-derived products. Many natural products and their analogues have been identified as potent anti-diabetic agents. Here, an attempt is being made through this article to provide an in-depth and comprehensive review on various plant species that have been explored as anti-diabetic agents.
      PubDate: 2015-05-24
      Issue No: Vol. 3, No. 3 (2015)
  • Effect of Moringa oleifera Lam. Ethanol Leaf Extract on Hematology in
           Phenylhydrazine-induced Anemic Albino Wistar Rats

    • Authors: Nku-Ekpang Okot-Asi T; Nwaehujor Chinaka O, Ofem Ofem E, Ezekiel Josiah I.
      Pages: 67 - 73
      Abstract: The study was designed to investigate the effect of ethanol leaf extract of Moringa oleifera Lam. in phenylhydrazine-induced anemic albino Wistar rats. Twenty five (25) rats of both sexes were randomly assigned to 5 groups. Group 1 (normal control), Group 2 (negative control) was challenged with Phenylhydrazine (40 mg/kg, i.p.) without treatment. Group 3 received M. oleifera extract at 300 mg/kg. Groups 4 and 5 were challenged with phenylhydrazine (40 mg/kg) and treated with 300 and 600 mg/kg of M. oleifera respectively. All treatments with the extract were per os. All animals were allowed free access to food and water pre and post treatment for 21 days. At the end of the treatment period, blood samples were collected from the rats via the retro-orbital plexus of the eye. The hematological parameters assayed for were red blood cell count, hemoglobin count, white blood cell count, packed cell volume, platelet count, mean cell volume, mean cell hemoglobin, mean cell hemoglobin concentration and lymphocytes count. Changes in body weight of the rats were also determined. Results showed that there was significant (P
      PubDate: 2015-06-02
      Issue No: Vol. 3, No. 3 (2015)
  • Antidepressant Effect of Diclofenac against Experimental Parkinson’s
           Rat Model

    • Authors: Sadaf Naeem; Rahila Najam, Nousheen Alam
      Pages: 74 - 78
      Abstract: Previous clinical studies confirm the presence of inflammatory mediators like tissue necrotic factor alpha (TNF-α) and interleukins-1β in depressive patients are the main cause of depression and the use of non-steroidal anti-inflammatory drugs (NSAIDs) especially cyclo-oxygenase-2 (COX-2) inhibitors are associated with a marked reduction in the symptoms of depression. In our study we investigated the role of diclofenac in ameliorating depression in chlorpromazine (CPZ) induced PD model. Forty Wistar albino rats were divided equally into 4 groups, Rats of group I (control) received only vehicles and had free access to food and water. Rats of groups II, III and IV were treated with chlorpromazine (3mg/kg/day ) via the intraperitoneal route once a day for 21 days. Diclofenac (20mg/kg/day) was given orally to group III and standard drug L-dopa/carbidopa (30mg/kg/day) orally was given to group IV for 21 days. Group II was negative control, and all treated group received 3mg/kg/day i.p CPZ for 21 days. CPZ was administered 30 min before the administration of test drugs, antidepressant effects of diclofenac were examined by using open field activity, cage crossing and forced swimming test. In the open field, diclofenac and standard drug (L-dopa/carbidopa) animals showed significant (P
      PubDate: 2015-07-05
      Issue No: Vol. 3, No. 3 (2015)
  • Hepatoprotective Effect of Ethanolic Leaf Extract of Vernonia amygdalina
           and Azadirachta indica against Acetaminophen-Induced Hepatotoxicity
           inSprague-Dawley Male Albino Rats

    • Authors: Momoh Johnson; Longe Adeteju Olufunmilayo, Damazio Olanrewaju Anthony, Eleyowo Oluwole Olusoji
      Pages: 79 - 86
      Abstract: Acetaminophen (paracetamol) is a commonly and widely used analgesic and antipyretic agent, but at high dose it leads to undesirable side effects, such as hepatotoxicity. The study investigate the hepatoprotective effect of ethanolic leaf extract of Vernonia amygdalina and ethanolic leaf extract of Azadirachta indica against acetaminophen-induced hepatotoxicity in Sprague -Dawley male albino rats. Male albino rats were randomly divided into six groups each consisting of five albino rats. Group A rats served as the normal control and were given water daily for a period of 14 days. Hepatotoxicity was induced in-vivo to all animals of Groups B, C, D, E, and F orally by administering 2g /kg body weight of paracetamol once a day for a period of 14 days. Group C, D, E and F were orally administered silymarin (100 mg/kg B.W), Vitamin C (100 mg/kg B.W), ethanolic leaf extract of V. amygdalina (300 mg/kg B.W) and A. indica (300 mg/kg B.W) respectively daily for a period of 14 days. Group B animals served as the paracetamol control and they were not treated. The result of this study shows that animals treated with silymarin, V. amygdalina and A. indica extracts significantly (P
      PubDate: 2015-07-05
      Issue No: Vol. 3, No. 3 (2015)
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