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American Journal of Pharmacological Sciences    [3 followers]  Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
     Published by Science and Education Publishing Homepage  [19 journals]
  • In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in
           Presence of Fruit Juice
    • Authors: Faisal Asif; Tania Sultana, Md. Didaruzzaman Sohel, Md. Helal Uddin Sumon, Md. Hassan Kawsar, Md. Ashraful Islam
      Pages: 32 - 36
      Abstract: This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.
      PubDate: 2014-02-20
      Issue No: Vol. 2, No. 2 (2014)
  • Designing, Proposed Synthesis and Docking Analysis of Novel Sulfonamide
           Derivatives as Antimicrobial Agents
    • Authors: Ajeet; Arvind Kumar
      Pages: 37 - 41
      Abstract: Substituted N-acetyl-4-amino-benzenesulfonamide derivatives were designed using ChemDraw Ultra 7.0 and energy minimization of derivatives was achieved with Chem3D Pro of ChemOffice suit, keeping in view the structural requirements of pharmacophore. Their proposed synthesis along with in-silico study (docking analysis) in favor of antimicrobial activity has been shown in this work with the possible mechanism of reaction. Docking studies were carried out to study the binding properties of drugs with molecular targets with the help of AutoDock Vina (Python-Prescription 0.8). Titled compounds (CS, DPS, SRS and TS) exhibited good binding properties with molecular target pseudomonas aeruginosa exotoxin A in Lamarckian genetic algorithm based flexible docking studies.
      PubDate: 2014-04-03
      Issue No: Vol. 2, No. 2 (2014)
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