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Journal Cover American Journal of Pharmacological Sciences
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  This is an Open Access Journal Open Access journal
     ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
     Published by Science and Education Publishing Homepage  [19 journals]
  • Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery

    • Authors: Pratibha G. Kakadia; Barbara R. Conway
      Pages: 1 - 7
      Abstract: Solid lipid nanoparticles (SLNs) have attracted increasing attention during recent years. Due to their unique size dependent properties, lipid nanoparticles offer possibilities to develop new therapeutics. The ability to incorporate drugs into nanoparticles offers a new prototype in drug delivery thus realizing the dual goal of both controlled release and site-specific drug delivery. Drug delivery to the skin is widely used for local and systemic delivery and has potential to be improved by application of nanoparticulate formulations. If investigated appropriately, solid lipid nanoparticles may open new opportunities in therapy of complex diseases which is difficult to treat.
      PubDate: 2104-09-22
      Issue No: Vol. 2, No. 5A (2104)
       
  • Breaking the Skin Barrier: Current Advancement in Drug Delivery via Skin

    • Authors: YU-LIN CHOU; Yasser Shahzad, Madeeha Malik
      Pages: 0 - 0
      PubDate: 2014-09-20
      Issue No: Vol. 2, No. 5A (2014)
       
  • Optimization and Permeation Study of Novel Topically Applied Antilipemic
           Lotion Using Central Composite Design

    • Authors: Asma Aslam; Rummana Riaz, Yasser Shahzad, Atif Akber, Ikram Ullah Khan, Syed Nisar Hussain Shah
      Pages: 8 - 14
      Abstract: In this study, synergistic effect of penetration enhancers, namely propylene glycol (PG) and sodium lauryl Sulphate (SLS) on transdermal absorption of 2-Methyl-2-phenoxy-propionic acid (MPA) was evaluated with aid of response surface methodology (RSM) based formulations. The prepared formulations were characterised and subsequently subjected to diffusion cell experiments through a well-established skin mimic, namely silicone membrane. Data obtained were statistically analysed using analysis of variance (ANOVA) and regression analysis. Comparisons were made with the control and among different parameters of formulations. PG (X1) and SLS (X2) were selected as independent variables, whereas the cumulative amount of MPA were used to calculate dependent permeation kinetic parameters like lag time (tlag) and enhancement ratios (ER). It was observed from the results that PG had a significant effect on MPA absorption from the lotion followed by SLS and their combination showed a significant enhancement (p< 0.05) in the flux from the formulated lotions compared to the control. The highest enhancement ratio (ER=8.6) was observed for L4. Contour plots were then drawn to depict the relationship between independent and response variables. Among the formulations, L4 showed highest flux value with less lag time (12.2 min), thereby, identified and selected as an optimized formulation. In conclusion, the combination of PG and SLS can be successfully utilized as permeation enhancers for transdermal drug delivery of MPA with minimal side effects.
      PubDate: 2014-09-30
      Issue No: Vol. 2, No. 5A (2014)
       
 
 
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