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Journal Cover American Journal of Pharmacological Sciences
  [3 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Antipyretic and Antianemic Activities of Three Anti-malaria Recipes from
           South Benin on Wistar Rats

    • Authors: Seindé Espérance MEDOATINSA; Cokou Pascal AGBANGNAN DOSSA, Sossa Pascal ATCHADE, Gbèdossou Sophie Reine BOGNINOU, Kossivi DOSSEH, Tchazou KPATCHA, Amegnona AGBONON, Hyacinthe AHISSOU, Dominique SOHOUNHLOUE
      Pages: 57 - 62
      Abstract: The present study aims to evaluate "in vivo" the acute toxicity, antipyretic and antianemic activities of three plant recipes used in the treatment of malaria in southern Benin lake cities on Wistar rats. We note the presence of saponosides, phenolic compounds, sterols and terpenes in the recipes studied. The toxicity evaluation of the extracts revealed that they are practically non-toxic (LD50> 5g/kg body weight) according to the Hodge and Sterner classification. All the extracts investigated contain antipyretic molecules but only two extracts (aqueous extract obtain by decoction of the child's recipe: 36.07 ± 0.48°C, hydroethanolic macerated of the adult’s recipe: 36.07 ± 0.33°C) showed significant antipyretic activity, similar to that of aspirin (36.03 ± 0.25°C) used as reference molecule in the present study. After evaluating the antianemic activity, we note that the extracts are not hemolytic.
      PubDate: 2017-10-25
      Issue No: Vol. 5, No. 3 (2017)
  • Development and In-Vitro Characterization of Ca-Alginate Beads of
           Oxytetracycline Hydrochloride for Oral Use: Effect of Process Variables

    • Authors: Lalit Kumar Tyagi; Ravi Shekhar, Kalpesh Gaur, Mohan Lal Kori
      Pages: 63 - 70
      Abstract: This work investigates the preparation of Oxytetracycline Hydrochloride loaded alginate beads to take advantage of the swelling properties of alginate beads for improving the oral delivery. Variations in polymer concentration, concentration of cross-linking agent and cross-linking time were examined systemically for their effects on the particle size, entrapment efficiency, percent yield, flow properties and In vitro drug release behavior. Calcium alginate (Ca-alginate) beads of Oxytetracycline hydrochloride were prepared by ionic-gelation method. Shape and surface characteristics were determined by scanning electron microscopy (SEM). Average particle size of drug-loaded beads was determined by sieving method. In vitro drug release behavior from Ca-alginate beads were carried out in simulated gastric fluid (SGF) for first 2 h and simulated intestinal fluid (SIF) for the next 6 h. SEM confirmed spherical shape of beads with rough and porous morphology. The average particle size of the beads was in the range of 470.96 ± 15.22 to 709.33 ± 16.28 µm. Results indicated that the average particle size and flow property of the beads increased with an increase in the concentration of polymer and the cross-linking agent as well as the cross-linking time. The entrapment efficiency and percentage yield was found to be in the range of 52.87 ± 1.56 to 61.76 ± 0.96 % and 69.98 ± 0.33 to 78.94 ± 0.43 % respectively. Concentration of the sodium alginate up to 1.75 % w/v, cross-linker concentration up to 2 % w/v and cross-linking time (30 min) shows highest percent entrapment efficiency (61.76 ± 0.96 %) and % yield (78.94 ± 0.43 %). A decrease in the rate and extent of drug release was observed with relative increase in the polymer concentration, cross- linker concentration and cross-linking time. No significant drug-polymer interaction was observed in DSC study. From this study it can be concluded that the natural polymer sodium alginate can prolong the release of Oxytetracycline Hydrochloride.
      PubDate: 2017-12-5
      Issue No: Vol. 5, No. 3 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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