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Journal Cover American Journal of Pharmacological Sciences
  [2 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Antiimplantation and Antiestrogenic Activity of Boerhaavia Diffusa Root
           Extract in Female Albino Rats

    • Authors: Neetesh Kumar Jain; Suman Jain, S C Mehta, S.D. Tonpay
      Pages: 15 - 19
      Abstract: Disturbance of the natural steroid hormone balance can successfully disorganize the co-ordinate events involved in ovulation, ovum transport and implantation. Thus, compounds possessing estrogenic, progestation and anti-estrogenic, anti-progestational or anti-implantation activity may also exhibit anti-fertility activity. The present study was conducted to investigate the antiimplantation and antiestrogenic activity of Boerhaavia diffusa root extract in female rats. Female albino rats were taken and divided into three groups. Group I served as control, group II received methanolic extract at dose of 200 mg/kg body weight and group III received methanolic extract at dose of 400 mg/kg body weight. The root extract of Boerhaavia diffusa evaluated for anti-implantation activity, The methanolic extract at a dose of 200 mg/kg body weight inhibited pregnancy with mean number of implants 5.58 ± 0.34 [P
      PubDate: 2016-2-27
      Issue No: Vol. 4, No. 2 (2016)
  • Complex B vitamins: Physiology and Therapeutic Effect on Pain

    • Authors: Alberto Mimenza Alvarado; Sara Aguilar Navarro
      Pages: 20 - 27
      Abstract: Complex B vitamins (B1, B6, and B12) have shown affect several metabolic routes in the organism. Vitamin B1, or thiamine, has anti-oxidative properties and significant effects on the nitric oxide-cGMP pathway, giving it anti-hyperalgesic and anti-allodynic properties. Vitamin B6, or pyridoxine, has modulatory effects on calcium channels, inhibiting glutamate synthesis and intervening in the metabolism of carbohydrates. Vitamin B12 shows reconstructive effects and increases epidermal growth factor synthesis. Combining them produces an additive effect that, apart from participating in vital body functions, can help treat diseases such as pain. It is important to know about the mechanisms that explain their analgesic and anti-allodynic effects, in order to understand the physiologic mechanisms involved in these actions. This article summarizes Vitamins B1, B6 and B12 actions, focusing in pain treatment.
      PubDate: 2016-3-11
      Issue No: Vol. 4, No. 2 (2016)
  • In silico Analysis and Molecular Docking Comparison of Curcumin and
           Bisdemethoxycurcumin on Transthyretin

    • Authors: Dong-Chan Kim; Jae-Ki Ryu
      Pages: 28 - 30
      Abstract: In this study, we investigated and compared the binding affinity of curcumin and its derivative, bisdemethoxycurcumin (BDMC), on the chain A domain of the transthyretin (TTR) protein by computational docking studies. The three dimensional crystallographic structure of TTR was obtained from PDB database (PDB ID: 4PMF). Computational docking analysis was performed using PyRx, Autodock Vina, and Discovery Studio Version 4.5 option based on scoring functions. The curcumin showed optimum binding affinity (docking energy) with TTR with the binding energy of -5.08 kcal/mol as compared to the BDMC (-4.76 kcal/mol). These results indicated that curcumin could be more potent ligands to the TTR than BDMC. Therefore, curcumin can be applied to the fields of the TTR-induced alzheimer's disease regulation.
      PubDate: 2016-3-25
      Issue No: Vol. 4, No. 2 (2016)
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