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Journal Cover American Journal of Pharmacological Sciences
  [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2327-6711 - ISSN (Online) 2327-672X
   Published by Science and Education Publishing Homepage  [72 journals]
  • Effect of Azilsartan, Aliskiren or Their Combination on Body Weight and
           Adipogenesis of High-fat Diet Induced Non-alcoholic Fatty Liver Disease in
           Rats

    • Authors: Rabab M. Utba; Saad A. Hussain, Ammar A. Fadhil, Angham Ahmed
      Pages: 31 - 34
      Abstract: The renin-angiotensin system (RAS) plays an important role in the pathophysiology of many diseases including non-alcoholic fatty liver disease (NAFLD). This study aims to evaluate the effects of blocking RAS with azilsartan, aliskiren or their combination on the body weight and adipogenesis in rat’s model of NAFLD. Thirty-two rats were allocated into four groups and treated with either vehicle, azilsartan, aliskiren or their combination. All groups were maintained on high-fat diet for 60 days, and their body weights were monitored each 3 days. At the end of treatment all animals were authenticated and visceral adipose tissues obtained and weighed. Azilsartan attenuates both the increase in total body and adipose tissue weight compared with control, while azilsartan alone affects adipogenesis only. In conclusion, Administration of azilsartan attenuates adipogenesis and obesity in rat’s model of high-fat diet induced NAFLD, while aliskiren affects adipogenesis only.
      PubDate: 2016-4-27
      Issue No: Vol. 4, No. 3 (2016)
       
  • Response Rate to Glyceryl Trinitrate as First Line Therapy in Patients
           with Chronic Anal Fissure in Kirkuk City

    • Authors: Hazm Sadiq Ahmed
      Pages: 35 - 38
      Abstract: Chronic anal fissure is common perianal condition. Surgical sphincterotomy is very successful at healing these fissures but requires an operation with associated morbidity. Temporary reduction in sphincter tone can be achieved on an outpatient basis by applying a topical nitric oxide donor (glyceryl trinitrate) 0.4% twice daily for four week duration. A total of 120 patients with chronic anal fissure were collected randomly from Kirkuk general hospital and private surgerical clinic prospectively from September 2014 till December 2015. Whether pharmacological treatment or surgical treatment is the best first line options in the treatment of chronic anal fissure will be the main issue of this study. Results: A total of 120 patients with chronic anal fissure were enrolled in this study. All patients received (GTN) as first line therapy for 4 week. 100 patients were able to complete medical treatment, while the remaining twenty patients were unable to complete medical treatments due to side effects caused by the drug. Regarding medical treatment outcome: 65 of patients(from total 100) (45 male, 23 female) achieved complete recovery and only 35 of patients (23 male, 12female) failed to reach complete recovery even after 4 week of treatment and undergoing sphincterotomy as second line options. About 91%(n=59) of patients achieved complete recovery within 2-3 week from the start of (GTN), and 9% (n=6) of patients recovered with complete 4 week administration of (GTN). Conclusions: digital application of glyceryl trinitrate as first line therapy for chronic anal fissure was the best choice for majority of patients, with treatment course of 4 week.
      PubDate: 2016-6-14
      Issue No: Vol. 4, No. 3 (2016)
       
 
 
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