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Journal Cover American Journal of Infectious Diseases and Microbiology
  [15 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4056 - ISSN (Online) 2328-4064
   Published by Science and Education Publishing Homepage  [72 journals]
  • Journal Publications, Indexing and Academic Excellence: Have We Chosen the
           Right Path

    • Authors: Venkataramana Kandi
      Pages: 52 - 55
      Abstract: Journal communications have been revolutionized by the evolution of the concept of online and open access publications. Even the older and traditional journals have adopted the online mode for paper submission, peer review and editorial procedures before a research communication is published. Most journals now have both an online and print version where in both are either freely available or available under subscription. Currently the situation of journal publications has been in a lot of criticism. This review attempts to elaborate on the current status of journal publication, indexing, impact factor, authorship and criteria for assessment of academic excellence.
      PubDate: 2016-5-12
      Issue No: Vol. 4, No. 3 (2016)
  • The Role of APACHE-II Score in Predicting Acinetobacter baumannii
           Colonization/Infection and Its Antimicrobial Resistance Pattern in
           Indonesian Teaching Hospital

    • Authors: Ian Huang; Gregoey Joey, Cucunawangsih, Oloan E. Tampubolon
      Pages: 56 - 60
      Abstract: Background: A first precautionary action against Acinetobacter baumannii (A.baumanii) can be conducted by identifying well-established risk factors of colonization/infection of that pathogen, such as underlying severity of illness. There are hardly any studies regarding the role of APACHE-II score in predicting risk of A.baumannii colonization/infection in Indonesia. Materials and Methods: A retrospective, case control investigation was performed with medical and microbiology records of ICU patients in an Indonesian Teaching Hospital from January 2013 to December 2014. Results: There were 39 patients with A.baumannii colonization/infection and 59 patients with non-A.baumannii colonization/infection enrolled in this study. Patients with A.baumannii colonization/infection had a significantly higher APACHE II score than non-Acinetobacter group, 25.7 and 23.1 (p=0.038), respectively. APACHE II score ≥ 23 had 74.4% sensitivity and 50.8 specificity to A.baumannii colonization/infection [odd ratio (OR) 3.00, 95% confidence interval (CI) 1.24-7.24, p=0.013], on the other hand APACHE II ≥ 27 had a 53.8% sensitivity and 78.0% specificity (OR 3.75, 95% CI 1.57-8.95, p=0.002). The highest susceptibility level of antibiotics against A.baumannii in this study was shown by tigecycline (82.1%) and amikacin (84.6%). Conclusions: APACHE-II score was strongly correlated with A.baumannii colonization/infection and a cut-off value of APACHE II score ≥ 23 may be used to depict increased moderate risk of A.baumannii colonization/infection. While the use carbapenem against A. baumannii infection was not recommended, tigecycline and amikacin may be considered as antibiotics of choice in treating A.baumannii infection in our hospital setting.
      PubDate: 2016-5-28
      Issue No: Vol. 4, No. 3 (2016)
  • Immunoinformatics Predication and in silico Modeling of Epitope-Based
           Peptide Vaccine Against virulent Newcastle Disease Viruses

    • Authors: Marwan Mustafa Badawi; Afra AbdElhamid Fadl Alla, Salma Sleak Alam, Wafa Aljack Mohamed, Duaa Adil Nasr-Eldin Osman, Samar Ali Abd Alrazig Ali, Entissar Mohamed Elhassan Ahmed, Abdah AbdElmonim Adam, Ranya Omar Abdullh, Mohamed Ahmed Salih
      Pages: 61 - 71
      Abstract: ewcastle disease virus (NDV) is negative sense single stranded RNA belongs to the Avulavirus genus of the Paramyxoviridae family which can be transmitted by inhalation or ingestion. Birds infected shed these viruses in feces as well as respiratory secretions. The aim of this study is to analyze fusion (F) protein of all virulent Newcastle strains reported in NCBI database using insilico approaches to select all possible epitopes that can be used as a therapeutic peptide vaccine. A total of 56 virulent NDV fusion protein variants retrieved from NCBI database. the conserved regions were introduced into IEDB analysis resource to predict B and T cell epitopes, as well as predicting the binding affinity of the conserved epitopes with BF2 21:01, from the predominantly expressed chicken MHC I molecule. Epitopes with high scores in both B and T cell epitopes predicting tools were suggested. Peptide vaccine against virulent NDV is strongly supersedes the conventional vaccines, as it designed to cover variant virulent mutated strains, which will reduce the recurrent outbreaks and their huge accompanied economical loss to a minimum.
      PubDate: 2016-6-20
      Issue No: Vol. 4, No. 3 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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