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Journal Cover   American Journal of Infectious Diseases and Microbiology
  [15 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4056 - ISSN (Online) 2328-4064
   Published by Science and Education Publishing Homepage  [72 journals]
  • Characterization of Bacterial and Fungal Colonizers of the Oral Cavity
           among the Human Immunodeficiency Virus (HIV/AIDS) Infected Individuals
           before and after Initiation of Highly Active Antiretroviral Therapy

    • Authors: Padmajakshi. G; S. Saini, K V Ramana
      Pages: 125 - 128
      Abstract: It is a well known fact that human immunodeficiency virus (HIV) infection is a word wide pandemic. HIV and acquired immunodeficiency syndrome (AIDS) with oral infections are among world’s most severe public health threat. HIV infection is associated with risk of developing opportunistic infections and especially contribute to oral infections which are further complicated as most of the infections are due to normal flora/microorganisms of endogenous origin. Therefore, rapid and early detection, isolation and characterization of these oral infections related to oral micro biome enhances knowledge of physicians involved in HIV patient care to control and prevent HIV infected individuals from future complications which could be responsible for severe morbidity and mortality. Asymptomatic carrier detection of potential pathogens is important to control infections and also act as a treatment guide for clinical and epidemiological purposes for both clinicians treating HIV patients and clinical microbiologists. Oral infections in HIV infected patients have become an increasing cause of clinical concern for several reasons: firstly they are associated with adverse clinical outcomes and secondly most of them are asymptomatic carriers. This study is an attempt made by us to determine the prevalence of oral micro biota and their association with opportunistic infections in HIV infected patients before and after initiation of highly active antiretroviral therapy (HAART).
      PubDate: 2015-07-14
      Issue No: Vol. 3, No. 4 (2015)
  • Activity of Linezolid against Multidrug-resistant Gram Positive Cocci in
           Eastern Nepal

    • Authors: Mr. Suraj Timilsina
      Pages: 129 - 133
      Abstract: Background: The emergence of resistance in gram-positive bacteria has necessitated a search for new antimicrobial agents. Linezolid, an oxazolidinone, is a new class of antibacterial agents with enhanced activity against pathogens. Method: The in-vitro activity of linezolid was assessed against 461 gram-positive cocci; 301 Staphylococcus spp., 150 Enterococcus spp., 5 Streptococcus pneumoniae and 5 Streptococcus pyogenes, with an emphesis on testing multidrug-resistant isolates. Results: Linezolid demonstrated potent activity against all the isolates tested at the susceptible breakpoint (≤4µg/ml). Against methicillin-resistant staphylococci and vancomycin-resistant enterococci, linezolid was the most active agent tested. Moreover, among 29.90% methicillin-resistant staphylococcal isolates, 20 exhibited intermediate susceptibility to vancomycin. Similarly, among the enterococcal isolates, 32% exhibited high level gentamicin-resistance whereas 7.33% were found to be vancomycin-resistant. None of the streptococcal isolates exhibited resistance to any of the antimicrobials tested. Conclusions: In summary, linezolid may represent an important therapeutic option for the treatment of infections caused by gram-positive cocci in Nepal.
      PubDate: 2015-07-28
      Issue No: Vol. 3, No. 4 (2015)
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