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Journal Cover American Journal of Infectious Diseases and Microbiology
  [18 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2328-4056 - ISSN (Online) 2328-4064
   Published by Science and Education Publishing Homepage  [72 journals]
  • Necrotizing Fasciitis without Surgeries – Only Lunatics May'

    • Authors: Yiu Ming Ho
      Pages: 1 - 3
      Abstract: Necrotizing fasciitis is a life threatening disease and patients suffering from the disease require urgent surgical debridement and adjunct board spectrum parental antibiotics. However, this axiom might be challenged since we have a case of non-surgically managed necrotizing fasciitis. This is the first survival case that extensive necrotizing fasciitis was managed with a non-operative approach. It is not unrealistic to postulate that there is a certain indolent subtype of soft tissue infection, without multi-organ dysfunctions, can be managed with antibiotics alone if the disease pattern is better understood in the future.
      PubDate: 2017-1-13
      Issue No: Vol. 5, No. 1 (2017)
       
  • A Computational Vaccine Designing Approached for MERS-CoV Infections

    • Authors: Hiba Siddig Ibrahim; Shamsoun Khamis Kafi
      Pages: 4 - 60
      Abstract: The emergence of a new novel coronavirus infections recently known as MERS-CoV, that characterize by quickly progressing disease with multiple organs failures, that’s resembles SARS-CoV outbreak in 2003-2004. MERS-CoV becomes a scientists and WHO objectives in order to try to stop pandemic infections by rapidly developing coronavirus vaccine; one of this techniques are epitope prediction vaccine by computational methods; in silico, because it can accelerate vaccine development process especially when the convention procedures they are difficult to be applicable, time -consuming, expensive and also need to approved by FDA. The aim of this study was to use IEDB software to predict the suitable MERS-CoV epitope vaccine against the most known world population alleles through four selecting proteins such as S glycoprotein, envelope protein and their modification sequences. The main aim of this study is the developing of MERS-CoV vaccine by using IEDB services as one of the computational methods; the output of this study showed that S glycoprotein, envelope (E) protein and S and E protein modified sequences of MERS-CoV might be considered as a protective immunogenic with high conservancy because they can elect both neutralizing antibodies and T-cell responses when reacting with B-cell, T- helper cell and Cytotoxic T-lymphocyte. A total numbers of B-cell epitopes represented 1, 3, 20 and 27 for E, modified E, S and modified S glycoprotein sequential but 18 epitopes were shared between S and modified S glycoprotein while for CTL were represented 63, 41, 602, 612 epitopes for E, modified E, S and modified S glycoprotein sequential and for T-helper cell they represented 685 epitopes for each of E and modified E proteins while they are 212 and 6896 epitopes for S and modified S glycoprotein sequential; NetCTL, NetChop and MHC-NP were used to confirm our results but still there are problems with most selected epitopes due to presence of arginine that hiding epitopes from recognition by immune system. Population coverage analysis showed that the putative helper T-cell epitopes and CTL epitopes could cover most of the world population in more than 60 geographical regions. According to AllerHunter results, all those selected different protein showed non- allergen, this finding makes this computational vaccine study more desirable for vaccine synthesis.
      PubDate: 2017-2-8
      Issue No: Vol. 5, No. 1 (2017)
       
  • Prevalence of Smear Positive Pulmonary Tuberculosis and Associated Risk
           Factors among Pulmonary Tuberculosis Suspected Patients at Private Health
           Institutions in Gondar Town, Northwest Ethiopia: A Cross-sectional Study

    • Authors: Martha Alemayehu; Abiy Tigabu, Solomon Yunkura, Fana Hagos, Birehanemeskel Tegene
      Pages: 61 - 65
      Abstract: Tuberculosis is one of the chronic human disease and serious public health problem in developing countries all over the world. It is the major cause of morbidity and mortality especially in sub-Saharan Africa. This study aimed to assess the prevalence and associated risk factors of smear positive pulmonary tuberculosis among tuberculosis suspected patients at private health institutions in Gondar town. A cross sectional study was conducted at private health institutions on 352 suspected patients. Spot morning sputum was collected and examined by Ziehl-Nelson staining technique. Data was processed by SPSS version 20 software. Out of 352 pulmonary suspected patients who gave sputum samples the prevalence of smear positive pulmonary tuberculosis were 19(5.4%). Among these 12(3.41%) were males while the remaining 7(1.99%) were females. The age ranged from 15 to 91 with mean age of 53 years. Age, average monthly income, low educational status, patients with previous history of chronic disease, contact with tuberculosis suspected cases and ingestion of raw milk were more prone to have pulmonary tuberculosis. So to overcome this problem the responsible bodies should participate to increase the awareness of the community for the prevention and control of tuberculosis.
      PubDate: 2017-3-1
      Issue No: Vol. 5, No. 1 (2017)
       
  • Antibacterial Activity of Some Non-steroidal Anti-inflammatory Drugs
           against Bacteria Causing Urinary Tract Infection

    • Authors: Eman Farouk Ahmed; Rehab Mahmoud Abd El-Baky, Abo Bakr F Ahmed, Nancy Gamil Waly, Gamal Fadl Mahmoud Gad
      Pages: 66 - 73
      Abstract: This study aims to evaluate the effect of NSAIDs on the activity of some antibiotics against urinary tract pathogens. Urine samples were collected and cultured on cysteine lactose electrolyte deficient (CLED) media and MICs for some antibiotics and NSAIDs were determined using Agar dilution method. The combined effects of some NSAIDs and some β-lactam antibiotics were tested on standard strains by checkerboard dilution technique. Out of 100 samples (63 female patients and 37 male patients suffering from UTIs), 122 bacterial strains were isolated. E. coli and Coagulase negative Staphylococci (CoNS) were the most common (39.3% and 26.2%, respectively), followed by S. aureus (9.8%), Klebsiella spp, Enterococcus faecalis (7.4% each), P. aeruginosa (3.2%), Streptococci, Proteus spp. (2.5% each) and Bacillus spp. (1.6%). Most strains showed high resistance against the tested antibiotics. Diclofenac sodium and indomethacin showed the lowest MIC90 against the tested strains. All the tested NSAIDs significantly lowered the MICs of antibiotics against the tested bacteria and FICIs for these combinations ranged from 0.004 to 0.5. In conclusion, NSAIDs significantly increased the therapeutic activity of the tested antibiotics showing good synergistic effect.
      PubDate: 2017-3-10
      Issue No: Vol. 5, No. 1 (2017)
       
 
 
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