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  Journal of Reports in Pharmaceutical Sciences
  [3 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2322-1232
   Published by Kermanshah University Homepage  [4 journals]
  • Preparation and Characterization of Camptothecin Grafted Chitosan
           Oligosaccharide Nanomicelles

    • Authors: Babak Tajani, Reza Tahvilian, Saeideh Khazaei, Komail Sadr Javadi, Ali Fattahi
      Pages: 1 - 11
      Abstract: Water soluble chitosan oligosaccharide (CHO) was hydrophobically modified with camptothecin (CPT) in different molar ratios of CPT, and characterized by FT-IR and 1H-NMR spectroscopy. Nanomicelles prepared by these copolymers were analyzed for size, zeta, and length of time they remain stable. The critical micelle concentration (CMC) and dissociation of micelles at physiological pH and acidic pH were also investigated. FT-IR and 1H-NMR spectroscopy approved chemical modification of CHO. Fluorometry study showed that the CMC of grafted copolymer decreased from 27.2×10 to 6.1×10 g/L with an increasing feeding ratio from 2.5 to 7.5. Particle size of CPT-CHO-2.5 and CPT-CHO-7.5 was 539 ± 152.15 and197.8±66 nm, respectively. The dissociation study showed that the micelles are stable, and the disassembly was not observed in water at 37ºC neither at pH of 7.4 nor at pH of 5.5. These phenomena make CPT-CHO micelles as stable polymeric micelles for drug delivery. 
      PubDate: 2015-02-14
      Issue No: Vol. 4, No. 1 (2015)
  • Analytical Utility of Potassium Permanganate for the Assay of Albendazole
           in Bulk Drug and Pharmaceuticals

    • Authors: Nagaraju Swamy, Kudige Nagaraj Prashanth, Kanakapura Basavaiah
      Pages: 12 - 23
      Abstract: Two rapid, simple, sensitive and cost-effective titrimetric and spectr-ophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in pharmaceuticals. In titrimetry (method A), ALB is oxidized by a known excess of potassium permanganate (KMnO4) in H2SO4 medium followed by the determination of unreacted permanganate by titration with ferrous ammonium sulphate (FAS). In spectrophotometry (method B), ALB is treated with a measured excess of permanganate in acid medium and the unreacted oxidant is measured at 545 nm. The molar ratio (stoichiometry) in titrimetry and the optimum assay conditions are studied. Titrimetry is applicable over 2-9 mg range and the calculations are based on a 1:1 (ALB: KMnO4) molar-ratio. In spectrophotometry, Beers law is obeyed over 8.0-64.0                 μg mL-1 concentration range of ALB. The molar absorptivity and Sandell sensitivity values are calculated to be 3.348 × 103 L mol-1 cm-1 and 0.08           μg cm-2, respectively. The limits of detection (LOD) and quantification (LOQ) are also reported for the spectrophotometric method. The applicability of the developed methods is demonstrated by the assay of ALB in pure drug as well as in commercial formulations.
      PubDate: 2015-02-21
      Issue No: Vol. 4, No. 1 (2015)
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