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  Journal of Reports in Pharmaceutical Sciences
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2322-1232
   Published by Kermanshah University Homepage  [4 journals]
  • Preparation and Characterization of Camptothecin Grafted Chitosan
           Oligosaccharide Nanomicelles

    • Authors: Babak Tajani, Reza Tahvilian, Saeideh Khazaei, Komail Sadr Javadi, Ali Fattahi
      Pages: 1 - 11
      Abstract: Water soluble chitosan oligosaccharide (CHO) was hydrophobically modified with camptothecin (CPT) in different molar ratios of CPT, and characterized by FT-IR and 1H-NMR spectroscopy. Nanomicelles prepared by these copolymers were analyzed for size, zeta, and length of time they remain stable. The critical micelle concentration (CMC) and dissociation of micelles at physiological pH and acidic pH were also investigated. FT-IR and 1H-NMR spectroscopy approved chemical modification of CHO. Fluorometry study showed that the CMC of grafted copolymer decreased from 27.2×10 to 6.1×10 g/L with an increasing feeding ratio from 2.5 to 7.5. Particle size of CPT-CHO-2.5 and CPT-CHO-7.5 was 539 ± 152.15 and197.8±66 nm, respectively. The dissociation study showed that the micelles are stable, and the disassembly was not observed in water at 37ºC neither at pH of 7.4 nor at pH of 5.5. These phenomena make CPT-CHO micelles as stable polymeric micelles for drug delivery. 
      PubDate: 2015-02-14
      Issue No: Vol. 4, No. 1 (2015)
  • Analytical Utility of Potassium Permanganate for the Assay of Albendazole
           in Bulk Drug and Pharmaceuticals

    • Authors: Nagaraju Swamy, Kudige Nagaraj Prashanth, Kanakapura Basavaiah
      Pages: 12 - 23
      Abstract: Two rapid, simple, sensitive and cost-effective titrimetric and spectr-ophotometric methods are described for the determination of albendazole (ALB) in bulk drug and in pharmaceuticals. In titrimetry (method A), ALB is oxidized by a known excess of potassium permanganate (KMnO4) in H2SO4 medium followed by the determination of unreacted permanganate by titration with ferrous ammonium sulphate (FAS). In spectrophotometry (method B), ALB is treated with a measured excess of permanganate in acid medium and the unreacted oxidant is measured at 545 nm. The molar ratio (stoichiometry) in titrimetry and the optimum assay conditions are studied. Titrimetry is applicable over 2-9 mg range and the calculations are based on a 1:1 (ALB: KMnO4) molar-ratio. In spectrophotometry, Beers law is obeyed over 8.0-64.0                 μg mL-1 concentration range of ALB. The molar absorptivity and Sandell sensitivity values are calculated to be 3.348 × 103 L mol-1 cm-1 and 0.08           μg cm-2, respectively. The limits of detection (LOD) and quantification (LOQ) are also reported for the spectrophotometric method. The applicability of the developed methods is demonstrated by the assay of ALB in pure drug as well as in commercial formulations.
      PubDate: 2015-02-21
      Issue No: Vol. 4, No. 1 (2015)
  • Effect of Tribulus Terrestris Aqueous Extract on Survival and Growth of
           Human Peripheral Blood Mononuclear Cells (Hpbmc) and Several Cancerous
           Cell Lines

    • Authors: Lida Mohamed khosroshahi, Marziyeh Nikoo, Zahra Hasanpoor, Ali Mostafaei
      Pages: 24 - 29
      Abstract:  Tribulus terrestris (TT) is a member of the Zygophyllaceae family. Traditional Chinese medicine recommends the use of TT for treatment of a variety of diseases. In the present study we further investigated anti-proliferative and cytotoxic effects of TT extract on normal and several malignant cell lines. For this purpose, TTwas collected and after authentication, aqueous extract was prepared. Cytotoxic activity of TT extract at different doses (5-640μg/ml) was determined by LDH assay. Proliferative activity of TT extract was determined by trypan blue staining and cell counting methods. The results showed that IC50 of the extract for cancer cell line is 320 μg/ml and it is higher for hPBMC. On the other hand, we observed proliferative effect of TT extract on hPBMC but not on malignant cell lines.
      PubDate: 2015-03-14
      Issue No: Vol. 4, No. 1 (2015)
  • Ultrasound-Assisted Surfactant-Enhanced Emulsification
           Microextraction-HPLC Determination of Low-Levels of Thiopental in Serum
           and Urine Samples

    • Authors: Mostafa Najafi, Afshin Pashabadi
      Pages: 30 - 42
      Abstract: An ultrasound-assisted surfactant-enhanced emulsification microextra- ction (UASEME) coupled with high performance liquid chromatography-diode array detection has been developed for the extraction and determination of thiopental in serum and urine samples. A simple microextraction method based on emulsification of organic extraction solvent in aqueous sample using an ionic surfactant and without any organic solvent was evaluated for preconcentration and extraction of trace amounts of thiopental. The surfactant was used as carrier and disperser agent simultaneously. The analyte was converted into their ion-pair complexes with tetra butyl ammonium bromide and then extracted into an organic solvent (chloroform) dispersed in aqueous solution. Some parameters affect the extraction efficiency, such as the type and volume of the extraction solvent, the type and concentration of the surfactant, sample pH, the ultrasound emulsification time and salt addition. These parameters were investigated and optimized. Under optimum conditions, the limit of detection (LOD) and enrichment factor for this technique were 0.084 ng mL−1 and 174 respectively. 
      PubDate: 2015-03-16
      Issue No: Vol. 4, No. 1 (2015)
  • Allura Red, the Artificial Azo Dye, Inhibits Esterase Activity of Carbonic
           Anhydrase II: A Preliminary Study on the Food Safety in Term of Enzyme

    • Authors: Reza Khodarahmi, Mohammad Reza Ashrafi-Kooshk, Koestan Khaledian
      Pages: 43 - 52
      Abstract: Allura red (AR) is a widely used colorant in food industry, but there is debate on its potential security risk. In this study, in vitro inhibitory properties of the dye against carbonic anhydrase (CA) were evaluated. The esterase activity of purified CA decreased in the presence of AR, in a dose-dependent manner. Regarding literature review and observed results, this preliminary study may provide new horizons in safety of AR and the other dye additives.
      PubDate: 2015-04-18
      Issue No: Vol. 4, No. 1 (2015)
  • Pharmaceutical Evaluation of Ziziphus Jujuba Mucoadhesive Buccal Film

    • Authors: Rahim Bahri-Najafi, Gholam Reza Asghari, Hamid Reza Dehlavi
      Pages: 53 - 64
      Abstract: Buccal mucoadhesive films have attracted great attention among mucoadhesive systems due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. The aim of the current study was to formulate the Ziziphus jujuba aqueous extract as buccal bioadhesive film, which continiously releases the drug at sufficient concentration for reducing the frequency of the administration times. Ziziphus jujuba fruit has caempferol compound which considered effective in treating gingivitis because of its anti-bacterial and anti-inflammatory effects. The mucoadhesive films were prepared using hydroxypropyl methylcellulose (HPMC) K4M, K15M and Eudragit RL100 polymers and propylene glycol as plasticizer by using solvent casting method. The physicochemical properties of films such as thickness uniformity, weight variations, swelling index, tensile strength, ex vivo adhesion force were evaluated. Films with high concentrations of HPMC K4M and K15M did not have favorable appearance and uniformity. The formulations prepared from Eudragit were transparent, flexible and without bubble. The highest and the lowest percentages of swelling were observed for the films containing HPMC K15M and Eudragit RL100, respectively. Films made of HPMC K15M had adhesion force higher than those containing Eudragit RL100. Drug release kinetics of all formulations followed Higuchi’s model and the mechanism of diffusion was considered non-Fickian type. It was concluded that formulations containing Eudragit RL100 were more favorable than others with regard to uniformity and flexibility. Keywords: Mucoadhesive; Buccal film; Ziziphus jujuba; Caempferol; Gingivitis; Eudragit polymer
      PubDate: 2015-04-20
      Issue No: Vol. 4, No. 1 (2015)
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