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  Journal of Reports in Pharmaceutical Sciences
  [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2322-1232
   Published by Kermanshah University Homepage  [4 journals]
  • Evaluation of Acute and 8-Week Sub-chronic Toxicities of aromatic water of
           Rheum ribes in rats.

    • Authors: Mahdi Mojarrab, kiumarth Ghanbari, Mohammad Shakeri, Zahra Minosh Siavash-Haghighi, Leila Hosseinzadeh
      Pages: 111 - 120
      Abstract: In Iranian folk medicine, especially in west of the country, the aromatic water of Rheum ribes has been used for several purposes such as fever reduction.  Despite the widespread use of this plant as food or as a medicinal plant, there is still lack of information on its toxicity profile.                                                               In the present study we aimed to evaluate the acute and sub chronic toxicities of aromatic water of R. ribes in Wistar rat. In the acute toxicity study, single doses of aromatic water were administered orally, and the rats were then monitored for 14 days. In the subchronic toxicity study, aromatic water was administered to rats for 60 days. Results of acute toxicity study indicated that the LD50 of R.ribes aromatic water is higher than 5000 mg/kg. Biochemical analysis showed aromatic water of R. ribes increased significantly Creatine Phospho Kinase (CPK) and Lactate De-Hydrogenase(LDH) levels. Moreover some significant abnormality of heart organ such as coagulated necrosis of cardiac muscle cells associated with hemorrhage, hypertrophy and infiltration of inflammatory cells were observed. Based on the result of this study, no observed adverse effect level (NOAEL) of aromatic water from R. ribes considered to be 250 mg/kg/day for male rats and 500 mg/kg/day for female rats.
      PubDate: 2015-08-10
      Issue No: Vol. 4, No. 2 (2015)
       
  • The effects of essential oil of Lavandula angustifolia on sperm parameters
           quality and reproductive hormones in rats exposed to Cadmium

    • Authors: Masoud Hamidi, Mojtaba Ziaee, Masoud Delashoub, Mahdi Marjani, Fatemeh Karimitabar, Nayeb Ali Ahmadi
      Pages: 121 - 128
      Abstract: Male infertility evaluation is important to recognize an origin and provide treatment if the etiology is correctable. The aim of the present study was to investigate the protective role of Lavandula angustifolia in impaired spermatogenesis caused by cadmium chloride in male rats. 36 male Wistar rats were allocated in 6 groups. Cadmium chloride was injected for 3 consecutive days (0.5 mg/kg) in CdCl2 treated groups. Before CdCl2 administration, pre-treatment with L. angustifolia was conducted for 14 consecutive days. Sex hormones level, malondialdehyde (MDA) and total antioxidant concentration as well as sperm parameters were investigated. Increase in the concentration of MDA and decrease in total antioxidant level were observed following CdCl2 administration. Accordingly, the sperm viability as well as other sperm characteristics was decreased. In the case of sex hormones, the testosterone and LH levels were decreased and the concentration of FSH was increased (P<0.001). Pre-treatment with L. angustifolia significantly decreased the MDA level and increased total antioxidant, LH and testosterone levels. Pre-treatment with L. angustifolia also improved semen parameters which were impaired by CdCl2 administration. Together, these results confirm that L. angustifolia pretreatment could protect spermatogenesis in male rats with CdCl2 administration.Together, these results confirm that Lavandula angustifolia pretreatment could protect spermatogenesis in male rats with CdCl2 administration.
      PubDate: 2015-08-10
      Issue No: Vol. 4, No. 2 (2015)
       
  • Assay of Pyrantel Pamoate Using Iron (III) Chloride and Three Complexing
           Agents by Spectrophotometry

    • Authors: Nagaraju Swamy, Kanakapura Basavaiah
      Pages: 129 - 140
      Abstract: Three rapid, simple, moderately sensitive and selective spectropho-tometric methods are described for the determination of pyrantel pamoate (PYP) in bulk drug and in its pharmaceutical formulations. The methods are based on the reduction of ferric chloride by PYP in neutral medium and subsequent complexation of iron (II) with ferricyanide (method A), 1, 10-phenanthroline (method B) and 2,2’-bipyridyl (method C). The absorbances of resulting colored products were measured at 750, 520 and 530 nm, respectively. Under the optimum conditions, Beer’s law enabled the determination of the drug in the concentration ranges 3.0-35, 1.0-30 and 2.0-35 µg mL-1 with apparent molar absorptivities of 1.38 × 104, 2.06 × 104 and 1.23 × 104 L mol-1 cm-1 for method A, method B and method C, respectively. The Sandell sensitivity values, limits of detection (LOD) and quantification (LOQ) values have also been reported for all methods. The accuracy and precision of the methods were evaluated on intra-day and inter-day basis; the relative error (%RE) was ≤ 3.0 % and the relative standard deviation (RSD) was ≤ 1.98 %. The developed methods were successfully applied to the determination of drug in tablets and suspension without interference by the common excipients.
      PubDate: 2015-08-10
      Issue No: Vol. 4, No. 2 (2015)
       
  • Evaluation of genoprotective effects of hydroalcoholic and polyphenolic
           extracts of Quince by Comet assay

    • Authors: Mahmoud Etebari, Behzad Zolfaghari, Abbas Jafarian-Dehkordi, Khadijeh Mousavi mobarakeh
      Pages: 141 - 147
      Abstract: Cydonia oblonga Mill.(Quince) is a member of Rosaceae family that widely used in Iraniantraditional medicine. This plantcontains large amounts of flavonoidsand polyphenols and has antioxidant, antibacterial,free radical scavenging and several other effects. This study was undertaken to evaluate the genotoxic and genoprotectiveeffects of hydroalcoholic and polyphenolicextracts of Quince on HepG2 cells. In evaluation of genoprotective properties, cells were incubated by different concentrations of extracts for 2 hours followed by one-hour incubation period with genotoxic concentration (100 µM) of Methyl Methane Sulfonate (MMS). In this research, comet assay as asensitive, inexpensive and easy performance methodwas used.Tail length, percentage of DNA in tail and tail moment were measured.The results showed that hydroalcoholic extracts of Quince at 1, 10, 100 and 500 µg/ml and polyphenolic extracts of Quince at 10, 50, 100 and 500 &#...
      PubDate: 2015-08-24
      Issue No: Vol. 4, No. 2 (2015)
       
 
 
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