for Journals by Title or ISSN
for Articles by Keywords
help
Followed Journals
Journal you Follow: 0
 
Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Jurnals are published.
Already have an account? Sign In to see the journals you follow.
Journal of Reports in Pharmaceutical Sciences
   Journal TOC RSS feeds Export to Zotero Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 2322-1232
     Published by Kermanshah University Homepage  [4 journals]
  • Synthesis, docking and cytotoxicity evaluation of
           N-(5-(Benzylthio)-1,3,4-thiadiazol-2-yl)-2-(3-methoxyphenyl)acetamide
           derivatives as tyrosine kinase inhibitors with potential anticancer
           activity

    • Authors: Ahmad Mohammadi-Farani, Tayebeh Bahrami, Alireza Aliabadi
      Abstract: In the recent years, targeted therapy of the neoplastic diseases is a current strategy used by oncologists. Hence, design and discovery of novel targeted anticancer therapeutics is an interesting topic in the current research of medicinal chemistry. A new series of 1,3,4-thiadiazole derivatives were prepared and their anticancer activity was assessed against PC3, SKNMC and HT29 cell lines by application of the MTT assay. Compound 3e with para positioning of the methoxy moiety demonstrated the highest inhibitory potency against PC3 (IC50 = 22.19 ± 2.1 µM) and SKNMC (IC50 = 5.41 ± 0.35 µM) cell lines in this series. This compound rendered a superior cytotoxic activity than imatinib. Compound 3f with ortho positioning of the fluorine displayed the most cytotoxic activity against HT29 cell line compared to other tested derivatives (IC50 = 12.57 ± 0.6 µM). Molecular docking studies on Abl as well as Src tyrosine kinases were also performed and potential hydrogen bindings were observed for ligand-receptor interaction.  
      PubDate: 2014-09-30
      Issue No: Vol. 3 (2014)
       
  • A novel method for simultaneous determination of codeine and acetaminophen
           in plasma by combination of UV-Vis spectroscopy and artificial neural
           network

    • Authors: Mohsen Shahlaei, Hadi Andisheh, Katayoun Derakhshandeh, Komail Sadrjavadi
      Abstract: A sensitive and selective method using combination of principal component analysis (PCA), artificial neural network (ANN) and UV-Visible spectroscopy has been developed for the simultaneous determination of acetaminophen (AMP) and codeine (COD) in plasma samples. The ANN trained by the back-propagation learning was employed to model the complex non-linear relationship between the PCs extracted from UV-visible spectra of medications and the absorbance values.  Optimal ANN model were as follows: Number of input PCs: 6, number of neurons in hidden layer: 5. The linear calibration range was 10-70 µg ml-1 and 40-700 µg ml-1, and the detection limit were 0.3 µg ml-1  and 1.3 µg ml-1, for AMP and COD, respectively. The results have been compared with those obtained by the HPLC method.
      PubDate: 2014-09-23
      Issue No: Vol. 3 (2014)
       
  • Targeting Gastric Cancer Stem Cells through Developmental Pathways:
           Hypothesis

    • Authors: Elham Patrad, Mojtaba Amani, Ali Niapour
      Abstract: Cancer stem cells (CSCs) have been defined as a unique subpopulation in tumors, endowed with the capacity to initiate tumor progression, maintain self-renewal as well as metastatic potential. Recently, more evidence strongly indicates the existence of CSCs in solid tumors of wide variety of organs such as breast, brain and stomach. Recent studies suggest that a special subpopulation of gastric cancer cells with specific marker namely CD44 shows spheroid colony formation in serum free media in vitro, as well as tumorigenic capacity in immunodeficient animal model in vivo. In addition, current evidences indicate that one of the major reasons for failure of chemo- and radiotherapy is the existence of CSCs with resistance mechanisms against current therapeutic strategies. Growing evidence recommended that pathways which are responsible for regulation of normal stem cell self-renewal and differentiation may also represent regulatory roles in maintenance of cancer cells and CSCs. Two major therapeutic approaches for eliminating of CSCs are differentiation therapy and inhibition of important pathways involved in maintenance of CSCs such as notch signaling. It is hypothesized  that with inhibition of notch signaling by means of DAPT (gamma-secretase inhibitor) as well as inducing differentiation by means of all-trance retinoic acid (ATRA) in CD44+  gastric cancer stem cells we can target this small population and eventually eliminate them by sensitizing these cells to chemo and radiotherapy as well as induction of apoptosis in them.
      PubDate: 2014-09-02
      Issue No: Vol. 3 (2014)
       
  • Formulation and Pharmaceutical Evaluation of Ferric-Maltol Floating Table

    • Authors: Rahim Bahri najafi, Lotfollah Saghaei, Narges Mollabashi
      Abstract: ABSTRACT                                                                             The new drug delivery systems have been developed, which can remain in the stomach for prolonged period of time. The effervescent floating tablet is one of these systems. Iron deficiency anaemia is a common disease in the world. Ferrous sulphate is the most common ferrous preparation used to treat and prevent iron deficiency, but it has little bioavailability and several complications. Ferric-maltol complex (FMC) is a ferric compound which doesn’t have ferrous complications. In this study FMC was used for preparing effervescent floating tablets that are designed to prolong the gastric residence time of drug, increase drug bioavailability and treat iron deficiency. At first the active ingredient (FMC) was synthesized from maltol and ferric chloride, the formation of complex was confirmed.  Eleven tablet formulations were designed using different amounts of gel-forming agents (HPMC K4M, Carbopol 934 P), and effervescent agents (sodium bicarbonate and citric acid). Pre-compression parameters of powder blend (bulk density, tapped density, angel repose, Carr’s index, hausner’s ratio) were measured; the tablets from each formulation were prepared by direct compression method. Buoyancy study of tablets was investigated. The F3-F11 tablets were selected for further post compression evaluations (thickness, hardness, friability, weight variation, drug content, in vitro dissolution study, swelling ability, drug release mechanism determination). F9, F10, F11 were the most appropriate formulations. They were very similar in consideration of swelling property, total floating time and drug release kinetic & mechanism. Among these three formulations, F11 was selected as the best formulation with more suitable buoyancy behavior. The F11 tablets were able to float immediately and remained buoyant for more than 18 hours. The drug release pattern followed zero order kinetic with non-fickian diffusion. 98.54% of FMC released from F11 floating tablets after 12 hours. Physical stability of F11 tablets was evaluated according to ICH guidelines. This formulation showed no-significant change in physical properties after storage at 40oC and 75% RH for 3months.
      PubDate: 2014-09-02
      Issue No: Vol. 3 (2014)
       
  • Oralmucoadhesive paste of Triamcinolone Acetonide and Zinc Sulfate:
           Preparation and in vitro physicochemical characterization

    • Authors: Katayoun Derakhshandeh, Razieh Abdollahipour
      Abstract: Aphthous stomatitis and oral lichen planus may be found on mucosal surfaces including the gingival, tongue and lips. These conditions frequently require topical corticosteroid medication such as TriamcinoloneAcetonide (TA). Recently, studies showed that divalent inorganic salts such as Zinc Sulphate (ZnSO4) are recommended for treatment of aphthouse, herpes ulcers and other ulcers in the body. In this study we developed orabase formulation of ZnSO4 0.25% and TA 0.1% that is suggested tohavesynergistic effect on ulcer treatment. To achieve this goal, different ratio of bioadhesive polymers such as pectin, gelatin, NaCMC and plastibase wereused and the effects of these factors was evaluated on physicochemical properties of the pastes.The in vitrobioadhesive strength, spreadability test and occlusivity strength properties of the Orabase were investigated using new designed device, while swelling behavior was studied in different media, namely, distilled water and simulated salvia solution. TA and ZnSO4 concentration were determined using HPLC and voltammetry system, respectively. The in vitro drug release was investigated in phosphate buffer (pH=7) at 37°C by Franz diffusion cell. The optimum formulation showed that the increase in NaCMC content and decrease in water content were found to elevate the bioadhesive and occlusivity strength. Also decrease in NaCMC content was found to elevate the drug release rate. Optimum formulation had adhesion strength equal to 131.948 mN/cm2, spreadability equal to 0.067 cm, percent of occlusivity strength equal to 53.3% and a swelling index very similar to brand sample (Adcortyl0.1%) in both the distilled water and phosphate buffer.We canclaim that optimum formulation is comparable to brand sample and we suggest that it is a promising and suitable carrier for transmucosal drug delivery system.
      PubDate: 2014-09-02
      Issue No: Vol. 3 (2014)
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-2014