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Journal Cover Journal of Interdisciplinary Histopathology
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  • Clinico-pathological Correlation in Diagnosis of Hansen’s Disease: A
           Histopathologist’s Perspective

    • Abstract: 2017-01-01T04-40-39Z
      Source: Journal of Interdisciplinary Histopathology
      Reshma Gopal Kini, Hemangini Choudhury.
      Objectives: Hansens’s disease follows a chronic course and though curable causes considerable degree of disability and deformity. Key to managing leprosy is it’s early diagnosis and treatment with multidrug regimen. Histopathological evaluation of skin biopsies play crucial role in the correct diagnosis of clinically ambiguous cases. Moreover classifying lesions by the Ridley-Jopling(RJ) system gives personalized information about the immulogical status of the individual and also aids in placing the patient in the correct treatment category. Materials and methods: Skin biopsies obtained from newly diagnosed cases of leprosy were included. Paraffin embedded sections stained with hematoxylin- eosin and Fite-Farracco were evaluated for features confirming leprosy and further categorized as per the RJ system. Sensitivity, specificity and concordance rates were looked for. Results: A total of 93 cases were studied after excluding those which had a component of reaction. Among the clinically suspected cases 93% of the biopsies were positive for leprosy. Sensitivity of clinical diagnosis ranged from 60% for borderline(BB) to 100% for histioid leprosy. Specificity ranged from 84.5% for borderline tuberculoid (BT) to 100% for neuritic leprosy. The agreement between histopathological and clinical diagnosis was more than 90% in all the subclasses except for BT which showed agreement in about 82% of the cases. Two of the cases were recategorized into multibacillary type of leprosy based histopathological evaluation. Conclusion: Confirmation of leprosy by examination of skin biopsy before starting the patient on long term multidrug therapy is invaluable. Experience of the leprologists and adherence to histopathological criteria as per the Ridley Jopling classification yield excellent concordance rates.

      PubDate: Sat, 31 Dec 2016 12:34:37 GMT
  • Edible Camphor-induced Histopathological Changes in Hippocampus and
           Cerebral Cortex Following Oral Administration into Rats

    • Abstract: 2016-12-17T04-35-15Z
      Source: Journal of Interdisciplinary Histopathology
      Oluwatobi T Somade, Damilola M. Ogunberu, Toyin T. Fakayode, Adeola O. Animashaun.
      Introduction: Raw edible camphor (EC), and as component of herbal infusions are widely used to treat pile, back pain, erectile dysfunction, and as an aphrodisiac especially in preparation for sexual intercourse by men. It has been traced in umbilical cord, blood, fetal, adipose, and other tissues including brain, where it bioaccumulates. Methods: The study, therefore, investigated the possible histopathological changes in brain, heart, and spleen that may result following EC administration in rats. Thirty animals were used for the study and were divided into six groups of five rats each. Group I animals served as normal control, Group II animals served as vehicle control and were orally administered 6 mL/kg corn oil daily for 7 days, while Groups III-VI animals were orally administered 1, 2, 4, and 6 g/kg EC for 7 days daily. Results and Conclusions: Following the administrations of various doses of EC, the histopathological changes seen in the cerebral cortex of the brain include mild submeningeal spongiosis, mild diffuse spongiosis of the parenchyma, a very mild diffuse gliosis, and presences of gitter cells, while in hippocampus, there were mild diffuse gliosis and disruption of the progression of the hippocampal horns, as well as foci of spongiosis around the hippocampal horns, and neuronal cells have open faced nuclei. No effect was seen in heart and spleen except 4 g/kg of EC that revealed moderate diffuse congestion in spleen only. In conclusion, EC may not have any toxic effects on the cardiac and splenic cells, but had toxic effects on the brain hippocampus and cerebral cortex, and may lead to brain cell damage.

      PubDate: Sat, 10 Dec 2016 11:08:43 GMT
  • Primary Adrenal Lymphoma Infiltrating in to Pancreas: A Rare Cause of

    • Abstract: 2016-12-10T09-39-39Z
      Source: Journal of Interdisciplinary Histopathology
      Lovelesh Kumar Nigam, Kamal V Kanodia, Aruna V Vanikar, Rashmi D Patel, Kamlesh S Suthar, Syed J Rizvi.
      Primary adrenal lymphoma is a rare entity and may be suspected in patients having bilateral adrenal masses, with/without lymphadenopathy, and with/without adrenal insufficiency. We report a rare case of a 45-year-old man who presented with pain in the abdomen, with no signs of adrenal insufficiency and bilateral adrenal masses on imaging. Light microscopy findings with immunohistochemistry and flow cytometry confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was offered cyclophosphamide, adriamycin, vincristine, and prednisolone chemotherapy regimen and doing well till the last follow-up.

      PubDate: Thu, 08 Dec 2016 13:15:31 GMT
  • The Significance of BerEp4 and Cytokeratin 19 Expressions in Epithelial
           Tumors of Kidney and Renal Pelvis

    • Abstract: 2016-12-10T09-39-39Z
      Source: Journal of Interdisciplinary Histopathology
      Ayhan Ozcan, Ibrahim Yavan, Melih Kilinc, Sami Uguz, Sukru Ozaydin.
      Objective: The differential diagnosis in the epithelial tumors of kidney and renal pelvis can be problematic due to their overlapping morphologic features. This is much more complicated in some conditions, such as renal oncocytoma (RO) vs chromophobe renal cell carcinoma (ChRCC) and renal cell carcinoma (RCC) vs urothelial carcinoma of renal pelvis (UC-RP). The purpose of this study was to assess potential contributions of BerEP4 and cytokeratin 19 (CK19) expressions in the differential diagnosis of these challenging cases. Methods: A total 57 cases consisted of 11 chromophobe (ChRCC), 18 clear cell (CCRCC), 12 papillary (PRCC), and 2 unclassified RCCs, 1 multilocular cystic renal cell neoplasm (MCRCN) with low malignant potential, 7 UC-RP, and 6 renal oncocytomas (RO) were stained against BerEp4 and CK19 antibodies using automated immunostainer.Results: All ROs demonstrated membranous BerEP4 expression, but no CK19 expression. Unlike ROs, most ChRCCs exhibited diffuse and strong CK19 expression, but no or focal and weak BerEP4 expression. This distinctive opposite expression pattern was highlighted in hybrid oncocytic chromophobe tumor (HOCT). CCRCCs showed highly variable expression patterns for both markers. PRCC type 1 tumors demonstrated diffuse and strong BerEp4 and CK19 expressions. PRCC type 2 exhibited BerEP4 and CK19 expressions, but their expressions were focal and weaker than for PRCC type 1. MCRCN demonstrated diffuse and strong BerEP4 expression, but no expression for CK19 unlike cystic CCRCC, which is strongly positive for both markers. Epithelioid cells in unclassified RCC showed strong CK19 and weak BerEP4 expression, whereas spindle cells in the tumor did not express CK19 and BerEp4 or exhibited scattered and weak expressions. UC-RP showed diffuse and strong CK19 expression, but no or scattered BerEP4expression was seen in the tumor. We also evaluated CK19 and BerEP4 expression in non-neoplastic adjacent kidney and renal pelvis.Conclusion: This study revealed that 1) BerEP4 and CK19 exhibit variable and distinctive immunoprofiles in epithelial tumors of kidney and renal pelvis, 2) an immunoprofile of BerEP4 (+)/CK19 (-) favors RO in contrast to an opposite profile for ChRCC, 3) The heterogeneous expressions of BerEP4 and CK19 in low grade RCC with eosinophilic cytoplasm favors HOCT, 4) PRCC type 1 strongly express both biomarkers, and 5) although RCC subtypes express CK19 in a variable proportion and intensity, diffuse and strong CK19 expression favors UC-RP.

      PubDate: Thu, 08 Dec 2016 12:58:59 GMT
  • Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on
           Diagnosis and Treatment

    • Abstract: 2016-10-29T02-55-12Z
      Source: Journal of Interdisciplinary Histopathology
      Bhagyalaxmi Hongal, Priya Shirish Joshi, Appasaheb Sanadi.
      Proliferative verrucous leukoplakia (PVL) is characterized by development of multiple keratotic plaques with roughened surface projections. Since its introduction in 1985 by Hansen et al., PVL of the oral mucosa still remains an enigma and is difficult to define as a sub-entity of leukoplakia. Although the lesion typically begins as simple, flat hyperkeratosis indistinguishable from ordinary leukoplakic lesion, PVL exhibits persistent growth and eventually becomes exophytic and verrucous in nature. As the lesion progresses, they may go through a stage indistinguishable from verrucous carcinoma but may later develop dysplastic changes or transform into full-fledged squamous cell carcinoma usually within 8 years of initial PVL diagnosis. PVL is unusual among the leukoplakia variants in having a strong female predilection and minimal association with tobacco usage. Presenting here, a case of PVL transforming into verrucous carcinoma with areas of suspected malignancy in a 53-year-old male with habit of chewing tobacco quid and beedi smoking 4-6 times a day since 20 years, with a chief complaint of pain and burning sensation of the oral cavity and multiple oral lesions for 1 month. This paper will elaborate typical behavior pattern of the lesion and will discuss this rare entity in light of current information.

      PubDate: Thu, 27 Oct 2016 13:03:13 GMT
  • Non-Goblet Cell Glandular Structures Underneath Non-Island Squamous
           Epithelium in Columnar Line Esophagus on Endoscopic Tissues: Frequencies,
           Forms, Associations, and Epithelial and Mucinous Characteristics

    • Abstract: 2016-10-22T02-56-28Z
      Source: Journal of Interdisciplinary Histopathology
      Hacer Ece Arslan Ozcan.
      Objective: Barrett’s esophagus (BE) may possess variable cell lineages, leading to different phenotypes. Unusual glandular forms are currently being considered by some authors as important structures in the development of BE. The aim of this study is to analyze the frequencies, patterns, forms, and epithelial and mucinous characteristics of non-goblet cell glandular structures residing underneath the usual non-island squamous epithelium. Materials and Methods: Endoscopic biopsy tissues and reports of 299 cases with non-dysplastic and non-cancerous histology were examined and analyzed retrospectively. The cases were grouped according to their histopathological and endoscopic diagnosis and the presence of hiatus hernia. 6-8 serial tissue sections were obtained and stained with hematoxylin and eosin and alcian blue/periodic acid-Schiff (pH 2.5). The sections were examined under light microscope. Results: Abnormal glandular structures, which were deemed atypical for normal adult esophageal mucosa, were detected in the specimens. These abnormal patterns were grouped as esophageal glands proper and/or ducts-like (n = 141), island of ectopic gastric mucosal-like (n = 73), and dilated-hybrid glands-like (n = 114). Independent of hiatus hernia positivity, these structures were more frequent in columnar line esophagus cases than in chronic esophagitis group. Tall cell epithelium with light purple/purple-blue mucinous content was the most frequently observed type in these structures. Conclusions: Non-goblet cell glandular elements residing underneath the usual non-island esophageal squamous epithelium, whether isolated or forming a unit bearing immature properties, should be considered as metaplastic precursors and interpreted histopathologically as BE.

      PubDate: Sun, 16 Oct 2016 06:11:20 GMT
  • Epithelioid Haemangioendothelioma with Actin+/Cytokeratin+ Myoblast-Like
           Cells: Report of a Case

    • Abstract: 2016-08-29T23-22-32Z
      Source: Journal of Interdisciplinary Histopathology
      Michal Zamecnik.
      An unusual case of epithelioid hemangioendothelioma (EHE) with immunohistochemical positivity for cytokeratin (CK), alpha-smooth muscle actin, and calponin (CALP) is presented. The lesion occurred in a 43-year-old man in the right frontal region, with clinical suspicion for an epidermoid cyst. It was excised completely. Grossly, an 8 mm nodule was well circumscribed, soft, and it had gray cut surface. Histologically, typical features of EHE were seen, such angiocentric localization, epithelioid cytomorphology with mild atypia, myxohyaline stromal matrix, a few slit-like vascular channels, and isolated vacuolated cells. In addition, the stroma contained numerous spindle cells resembling myoblasts or myofibroblasts. They showed, besides scattered positivity for vascular markers, focal positivity for CALP and diffuse strong expression of alpha-smooth muscle actin and pancytokeratin AE1/AE3. This observation of numerous actin+/CK+cells is unusual. The lesion resembled other CK-positive vascular tumors and actin-positive myofibroblastic lesions, all of which has to be considered in differential diagnosis.

      PubDate: Fri, 26 Aug 2016 14:43:47 GMT
  • Unmasking the Grey Zone of Hyalinization with a Proposed Classification of
           Oral Hyalinizing Lesions

    • Abstract: 2016-08-29T23-22-32Z
      Source: Journal of Interdisciplinary Histopathology
      Tajindra Singh Saluja, Janaki Iyer.
      Histopathology encompasses a variety of formations projected as different shades of pink and purple. The appearance of every specific substance is attributed to the pathogenesis or process of its very being. Hyalinization is one such routinely encountered appearance, the pathogenesis of which remains untouched. Thus, an attempt has been made to unveil the gray zone of hyalinization as well as clinically correlate it to oral lesions. A classification for oral lesions showing hyalinization has also been proposed.

      PubDate: Fri, 26 Aug 2016 14:10:42 GMT
  • Immunohistochemical Expression of P53 Protein in Cutaneous Basal Cell
           Carcinoma: A Clinicopathological Study of 66 Cases

    • Abstract: 2016-08-29T23-22-32Z
      Source: Journal of Interdisciplinary Histopathology
      Vladimír Bartoš, Milada Kullová.
      Objective: Nuclear expression of p53 protein is associated with a biological behavior in a variety of human malignancies. In cutaneous basal cell carcinoma (BCC), however, many studies have provided conflicting results in this regard. We aimed to determine whether there is relationship between p53 expression and different histologic subtypes of BCC, and whether it may indicate tumor aggressiveness. Materials and Methods: Biopsy samples from 66 cutaneous BCCs from 57 patients were collected. P53 expression was demonstrated by immunohistochemical staining using the anti-p53 antibody. Among them, 52 cases were also evaluated for Ki-67 antigen. Results: Immunoreactivity of p53 protein varied in the range of 0 to 100% of total tumor tissue (mean value 46.0%). The expression exceeding 5% of cancer tissue (positive staining) was found in 54 BCCs (81.8%). Within this group, there were 25 cases (37.9%) with low and 29 cases (43.9%) with high expression. In superficial, superficial-nodular, nodular, nodular-infiltrative and infiltrative BCCs, p53 protein positivity was found in 100% (8/8), 80% (8/10), 70.4% (19/27), 88.2% (15/17) and 100% (4/4), respectively. We did not reveal a significant correlation between the extent of p53 protein expression and BCC subtypes except for nodular BCC, in which a number of negative cases (8/27, 29.6%) were just above the threshold of statistical significance (P = 0.04). After merging cancers into non-aggressive and aggressive growth phenotype, no association with expression of p53 protein was found. There was no relationship between p53 protein expression and topographical sites after they have been gathered into sun-exposed and sun-protected locations. We did not observe any association between expression of p53 protein and Ki-67 antigen. Conclusion: In cutaneous BCC, the expression of p53 protein does not seem to reflect a biological behavior and tumor aggressiveness. Therefore, in a routine dermatopathological practice, immunohistochemical assessment of p53 protein may not serve as a reliable prognosticator of this malignancy.

      PubDate: Fri, 26 Aug 2016 13:49:25 GMT
  • Mysterious Myofibroblast: A Cell with Diverse Origin and Multiple

    • Abstract: 2016-07-25T23-15-26Z
      Source: Journal of Interdisciplinary Histopathology
      Sowmya Rao, Jagadish Rao, Jyothi B.M, Varsha V.K.
      Myofibroblasts are one of the most controversial cells in recent times. Ever since its first discovery, numerous discussions have been done on its illusive nature and functions. They are commonly considered as smooth muscle like fibroblasts. Their presence and distribution in normal and pathological conditions are still not clear since they are difficult to identify with the routine histological techniques. Recent studies have shown their ubiquitous presence in the body tissues hence suggesting their important role in both physiological functioning and pathological conditions. This review discusses briefly the cell in terms of its definition, possible precursors; mechanism involved in its modulation, most importantly how to differentiate it from its nearest counterparts such as fibroblasts and smooth muscle cells and finally its fundamental role in physiology and pathology.

      PubDate: Thu, 21 Jul 2016 00:16:27 GMT
  • The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell.,
           At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats

    • Abstract: 2016-07-15T04-15-35Z
      Source: Journal of Interdisciplinary Histopathology
      Lucas Giglio Colli, Mirian Campos dos Santos, Jéssica Tambor, Isabel Cristina Cherici Camargo.
      Popular use of Cordia ecalyculata extract is increasing due to its potential in inhibiting appetite. Its side effects on reproduction have not yet been reported. Thus, for the first time, this study investigated the potential reproductive toxicity of different doses of C. ecalyculata extract in adult male rats (n = 12/group), which received hydroethanolic extract of C. ecalyculata at 20, 100, or 400 mg/kg of body weight (b.w.) or distilled water (control group), orally (gavage) for 60 consecutive days. The testicular and epididymal tissue, sperm morphology, fertility, and pregnancy outcome were evaluated. The results showed that food consumption decreased significantly in the groups that received 20 or 400 mg/kg of extract, but b.w. was similar (P> 0.05) in all experimental groups. No significant alteration was observed in testicular weight. At the 400 mg/kg dose, the epididymal relative weight increased (P < 0.05), compared to the control group. There were several histopathological changes in testes and epididymis at all extract doses. In addition, the percentage of abnormal gametes increased (P < 0.05) and the gestation rate decreased (P < 0.05). In conclusion, the C. ecalyculata extract promotes reproductive toxicity in rats, but with no dose-dependent effect.

      PubDate: Mon, 11 Jul 2016 05:06:44 GMT
  • Plasmablastic Lymphoma: A Report of 2 Cases with Review of Literature.

    • Abstract: 2016-07-04T23-15-35Z
      Source: Journal of Interdisciplinary Histopathology
      Geetha Vasudevan, Brij Mohan Kumar Singh, Arijit Bishnu, Abhijat Kulshreshta.
      Plasmablastic lymphoma (PBL) is an aggressive subtype of Non-Hodgkin Lymphoma (NHL) initially described in extra-nodal sites in an immunocompromised and later in immune-competent patients. PBL remains a diagnostic challenge due to morphological overlap with various other entities and also due to similarities on immunohistochemistry with plasma cell myeloma. In-spite of therapeutic advances, PBL remains an aggressive disease with high fatality rate. We describe 2 cases of this uncommon neoplasm; both in immunocompromised patients.

      PubDate: Fri, 01 Jul 2016 04:52:37 GMT
  • Characterization of the Blood Brain Barrier in Pediatric Central Nervous
           System Neoplasms

    • Abstract: 2016-06-30T09-15-32Z
      Source: Journal of Interdisciplinary Histopathology
      Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss.
      Objective: The normal blood–brain barrier (BBB) is composed of tight junctions between endothelial cells and surrounding astrocyte foot processes. Breakdown of the physiological astrocyte-endothelial cell relationship occurs in adult metastatic and primary brain tumors. However, the astrocyte-endothelial cell relationship has not been studied in pediatric tumors. Materials and Methods: Utilizing specimens from cases of pilocytic astrocytoma (n = 5), medulloblastoma (n = 5), and low-grade diffuse astrocytoma (n = 1), immunofluorescence were performed using primary antibodies against CD31, glial fibrillary acidic protein (GFAP), and aquaporin 4 (AQ4). Clinical, magnetic resonance imaging, operative, and histopathological findings were analyzed. Results: Strongly-enhancing areas of medulloblastoma exhibited complete BBB breakdown with sparse GFAP and AQ4 staining around CD31-positive vessels. Moderately enhancing regions of pilocytic astrocytomas exhibited regions of intact BBB and vasculature surrounded by dense GFAP staining but reduced and disorganized AQ4 staining, suggesting tumor cells could not fulfill physiological BBB support. Non-enhancing low-grade diffuse astrocytoma demonstrated intact BBB with intense peri-microvasculature GFAP and AQ4 staining. AQ4 stained so strongly that AQ4 visualization alone delineated CD31-positive vessels. Conclusion: Taken together, BBB breakdown in pediatric tumors corresponds to a loss of normal endothelial cell-astrocyte foot process relationships. Further development of pharmaceutical agents capitalizing on this disrupted BBB is warranted in medulloblastoma and pilocytic astrocytoma. However, BBB integrity remains a challenge in treating low-grade diffuse astrocytoma before progression toward secondary glioblastoma.

      PubDate: Mon, 27 Jun 2016 00:32:42 GMT
  • Pilomatrical Carcinoma in the Thigh: A Case Report and Review of

    • Abstract: 2016-06-24T23-15-29Z
      Source: Journal of Interdisciplinary Histopathology
      Marwa A. Abd Elazeem, Dina Adel Radi.
      Pilomatrical carcinoma is a rare malignant hair follicle tumor. It may arise de novo or as a malignant transformation from benign pilomatricoma. The tumor is locally aggressive with an increased tendency of recurrence but with a low metastatic potential. A 51-year-old male patient presented with a slowly growing mass in the middle inner aspect of the left thigh. After surgical excision, microscopically the tumor was diagnosed as pilomatrical carcinoma.

      PubDate: Fri, 24 Jun 2016 00:17:37 GMT
  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology
           in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia
           Amygdalina (Del.) Leaf

    • Abstract: 2016-06-24T23-15-29Z
      Source: Journal of Interdisciplinary Histopathology
      Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke.
      Background: Cadmium (Cd) is a toxic heavy metal of both environmental and occupational concerns. The health impact of ethno-botanical approaches in attempts to ameliorate its deleterious effects in biological systems should be an area of scientific interest since established therapies are often burdened with undesirable side effects. Aim: To determine the effects of polyphenol-rich extract of the leaf of Vernonia amygdalina (PEVA) on Cd-induced testicular toxicity, oxidative stress, and histopathology in Wistar rats. Materials and Methods: A total of twenty five (25) male Wistar rats were divided into five groups as follows: Group 1 (Control) received distilled water (0.2 ml/100 g i.p.) for 5 consecutive days and thereafter left untreated for 28 days. Group 2 received Cd alone at 5 mg/kg (i.p.) for 5 consecutive days. Group 3 was pre-treated with Cd as Group 2 and thereafter left untreated for a period of 28 days, whereas Groups 4 and 5 were pre-treated with Cd as Group 2 and thereafter received PEVA (orally) at two dose levels (200 and 400 mg/kg, respectively) for 28 days. Results: Cd administration induced reproductive toxicity as evidenced by lowered level of follicle stimulating hormone, luteinizing hormone, and testosterone (P < 0.05); perturbation of sperm characterization (P < 0.05); deleterious disruptions of the antioxidant system as evidenced by lowered levels of reduced glutathione and superoxide dismutase as well as elevation in thiobarbituric acid reactive substances level (P < 0.05); decrease in relative testicular weight (P < 0.05); and severe disseminated necrosis of the seminiferous tubules with terminally undifferentiated/necrotic cells as revealed by the histopathological examination. These conditions were sustained following administration of the two dose levels of PEVA. Conclusion: PEVA administration is not a suitable therapeutic choice for fertility enhancement in male Wistar rat model of Cd-induced decline in reproductive function.

      PubDate: Thu, 23 Jun 2016 01:52:28 GMT
  • Idiopathic Inflammatory Myopathies: An update

    • Abstract: 2016-06-15T09-17-54Z
      Source: Journal of Interdisciplinary Histopathology
      Bulent KURT, Serdar TASDEMIR, Ertugrul CELIK, Kemal INAN.
      Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of disease with complex clinical features. It has been sub-classified as: (1) Dermatomyositis, (2) Polymyositis, and (3) Inclusion body myositis (IBM). Nowadays, there are some studies in literature suggest necrotizing autoimmune myopathy and immune-mediated necrotizing myopathy should also be added to this group of disease. There is a debate in the diagnosis of IIMs and up until now, about 12 criteria systems have been proposed. Some of the criteria systems have been used widely such as Griggs et al.’s proposal for IBM. Clinical findings, autoantibodies, enzymes, electrophysiological, and muscle biopsy findings are diagnostic tools. Because of diseases’ complexity, none of the findings are diagnostic alone. In this study, we discussed the diagnostic criteria of IMMs and described detailed morphological features.

      PubDate: Sun, 12 Jun 2016 15:19:18 GMT
  • Primary Epithelioid Angiosarcoma of the Adrenal Gland: Report of a Case
           and Review of the Literature

    • Abstract: 2016-06-15T09-17-54Z
      Source: Journal of Interdisciplinary Histopathology
      Malek Mohamed Ayadi, Nadia Boujelben, Raoudha Doghri, Mouna Rezgani, Imen Abbes, maha driss, Riadh Chargui, Karima Mrad, Khaled Rahal.
      Primary mesenchymal neoplasms of the adrenal gland are extremely rare. The most common primary sarcoma is adrenal angiosarcoma. We report the case of a 51-year-old patient who presented with left flank pain. After ultrasound investigations, the patient underwent surgical removal of an adrenal tumor. The gross adrenal specimen showed extensive cystic changes with old hemorrhage and necrosis. Histologically, irregular branching vascular channels were seen intermixed with solid areas of epithelioid cells. Immunohistochemical staining of tumor cells was positive with antibodies to cytokeratin and CD31. After a 12 months follow-up, the patient is still well with no sign of a relapse. Because of the epithelioid appearance and frequent expression of epithelial immunohistochemical markers, primary epithelioid angiosarcoma of the adrenal gland can be confounded with adrenal carcinomatous metastases. We report our findings with a brief literature review and discussion of differential diagnosis.

      PubDate: Sun, 12 Jun 2016 04:51:09 GMT
  • Radiotherapy-Induced Ovarian Sarcoma Following the Treatment of Cervical
           Cancer: Exceptional Case Report and Review of the Literature

    • Abstract: 2016-06-15T09-17-54Z
      Source: Journal of Interdisciplinary Histopathology
      Malek Mohamed Ayadi, Olfa El Amine El Hadj, Ines Zemni, Hatem Bouzaiene, Jamel Ben Hassouna, Amor Gamoudi, Khaled Rahal.
      Primary ovarian sarcomas are rare gynecological tumors accounting for

      PubDate: Sun, 12 Jun 2016 04:34:51 GMT
  • On The Use of Human Tissues in Research and Practice

    • Abstract: 2016-06-15T09-17-54Z
      Source: Journal of Interdisciplinary Histopathology
      Sergei V. Jargin.

      PubDate: Sat, 11 Jun 2016 15:56:54 GMT
  • Pleomorphic Lobular Carcinoma of the Breast: Clinicopathological Analysis
           of a Distinctive and Rare Variant of Lobular Carcinoma

    • Abstract: 2016-06-15T09-17-54Z
      Source: Journal of Interdisciplinary Histopathology
      Olfa El Amine, Leila Bouhaja, Ines Chaar, Aida Goucha, Ahmed El May, Amor Gammoudi.
      Pleomorphic lobular carcinoma (PLC) of the breast is an uncommon variant of invasive lobular carcinoma (ILC), accounting for 0.67% of all breast carcinomas and

      PubDate: Thu, 09 Jun 2016 06:35:35 GMT
  • CMV endometritis in a non- immunosuppressed patient presenting as
           recurrent pyometra- A case report

    • Abstract: 2016-06-02T23-16-58Z
      Source: Journal of Interdisciplinary Histopathology
      Dr. Geetha Vasudevan, Dr Pavithra Prabhakar, Dr. Shephali Sharma.
      Cytomegalovirus infection of the female genital tract is a rare entity. We present a case of 70 year old woman who came with recurrent pyometra, but was otherwise in good health. Hysterectomy was done and the endometrium showed occasional stromal cells with karyomegaly and intranuclear eosinophilic inclusions consistent with cytomegaloviral infection and dense lymphoplasmacytic infiltrate. This was an incidental finding in an otherwise immunocompetent nonpregnant woman, hence being reported for its rarity and uncommon presentation. Keywords: cytomegalovirus, inclusions, endometrium.

      PubDate: Tue, 31 May 2016 05:09:31 GMT
  • Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin
           Expression in Astrocytic glioma

    • Abstract: 2016-05-07T09-15-50Z
      Source: Journal of Interdisciplinary Histopathology
      Aziza E. Abdelrahman, Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, Abdel-Motaleb Mohamed.
      Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression and therapy resistance. Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters.Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed.Results: The cases included 10 low grade, 12 anaplastic and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (p < 0.001). Nestin was strongly correlated to survivin index (p < 0.001). The univariate analysis showed that high histological grade, high nestin score and high survivin index were significantly correlated with overall survival. Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (p = 0.011). Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor overall survival. Therefore, nestin and survivin could be used to predict high risk group of astrocytoma with unfavorable outcome.

      PubDate: Tue, 03 May 2016 23:37:02 GMT
  • Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic

    • Abstract: 2016-04-26T19-06-38Z
      Source: Journal of Interdisciplinary Histopathology
      Sarala Ravindran, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, Yip Cheng Har.
      We present a rare distinctive variant of invasive carcinoma of breast characterized by adnexal differentiation of tumor of trichoblastic type. The neoplasm was identified in a mastectomy specimen from an 83-year-old Chinese woman. Morphologically, the trichoblastic differentiation was characterized by the formation of solid sheets and nests of basaloid cells. The tumor cells were positive for cytokeratin 5/6, BER-EP4, bcl-2, and β-catenin. Stromal cells were positive for CD10. The tumor cells exhibited a “triple negative” profile; the nuclei did not react with antibodies to estrogen and progesterone receptors but failed to show overexpression of the HER2/neu protein. The MIB-1 labeling index averaged 20%. It is hoped that this case increases awareness for this unique morphological variant of invasive ductal carcinoma.

      PubDate: Sun, 24 Apr 2016 07:50:20 GMT
  • C-kit (CD117) Expression Is Not Valuable to Predict Prognosis in Invasive
           Ductal Carcinoma of Breast

    • Abstract: 2016-04-06T20-37-17Z
      Source: Journal of Interdisciplinary Histopathology
      Maha Shomaf, Al-Motassem Yousef, Jamal Masad, Murad Sahawneh, Ahmad Halawa.
      Objective: C-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types as gastrointestinal stromal tumor, malignant melanoma, breast and lung cancer, sarcoma and mastocytosis. C-kit expression in malignant tumors can be a factor that might affect the prognosis and its expression in different tumors was studied in respect of its correlation with the outcome. Imatinib or sunitinib therapy of KIT-positive tumors is an example of a targeted cancer therapy requiring immunohistochemical tumor analysis to identify patients that would benefit from this kind of therapy. This study is done on patients with breast cancer to find out the frequency of c-kit expression and to find out if it has any effect on the outcome of the patients and to compare the results with that of other ethnicities. Materials and Methods: Paraffin-embedded tumor tissues from 81 patients with breast invasive ductal carcinoma were analyzed immunohistochemically for c-kit expression and correlated to the survival of the patients after initial diagnosis using the follow-up data. Results: The mean age of the patients was 52.8 years. The median follow-up period was 22 months (range 1-37 months). C-kit immunopositivity was found in 37 cases (46%). Expression of c-kit was found in tumor samples with varying intensities and infrequently. Conclusion: There was no significant correlation between c-kit expression and prognosis.

      PubDate: Sun, 03 Apr 2016 06:23:52 GMT
  • Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following
           Administration of Low Dose of Carica Papaya Leaf

    • Abstract: 2016-04-06T20-37-17Z
      Source: Journal of Interdisciplinary Histopathology
      Felix M Onyije, Vivian C Zenebo, Julius K Bankole, kester A Digban, Godwin O Avwioro.
      Background: The use of Carica papaya leaves for medicines and food in our rural areas is rampant, this is due to its availability and testimonies of its efficacy. Objective: This study was aimed at investigating the activities of C. papaya on the histo-architecture of some organs. Materials and Methods: About 20 Wistar rats were randomly divided into 4 groups of 5 each and received tap water, 2.5, 5, and 7.5 g/kg of ethanolic extract of C. papaya PO once a day for 14 days after which biochemical analyses was performed on the blood samples. The tissues were examined histologically. Results: Albumin was significantly increased (37.6 ± 2.70) in Group B (5 mg/kg) when compared with the control (32.4 ± 2.30). AST decreased significantly in all the treatment groups (68 ± 1.58, 87.4 ± 403, and 89 ± 1.58) when compared with the control (93.6 ± 1.14). ALT decreased in all groups but was significant in Group C (7.5 mg/kg) 22.8 ± 2.16 when compared with the control (30 ± 2.12). Urea decreased significantly in all the groups (3.34 ± 0.11, 3.78 ± 0.50, and 3.36 ± 0.28), creatinine decreased significantly in Group B (35.4 ± 2.79) when compared to their controls (4.52 ± 0.37 and 50.8 ± 6.37), respectively. Na+ and K+ significantly decreased in Groups C and B, respectively; there was no significant difference in other groups and electrolytes. There was increased level of both packed cell volume and hemoglobin significantly. Histologically, there were no tissue alterations in all the treatment groups.Conclusion: Complementary and alternative medicine is fast gaining popularity; this necessitates swift research on various dose ranges.

      PubDate: Sat, 02 Apr 2016 10:42:01 GMT
  • Prognostic Implication of MYSM-1 and Twist-1 in Renal Cell Carcinoma

    • Abstract: 2016-03-02T09-17-51Z
      Source: Journal of Interdisciplinary Histopathology
      Ola Harb, Abdelmonem Hegazy, Maged Ali, Rasha Haggag.
      Objective: The data available regarding the epithelial-mesenchymal transition (EMT) markers are little. This study aimed to evaluate the immunohistochemical expression of EMT markers; MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 in renal cell carcinoma (RCC), in a trial to find their role in the prognosis of such type of cancer. Methods: Immunoexpressions of MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 were assessed in tissue specimens of 50 patients with RCC, and correlated with other clinicopathological features. The findings and their correlations were statistically determined. Results: Low expression of MYSM-1 was negatively correlated with size of the tumor, primary tumor (pT) stage, Fuhrman grade (P < 0.001), age (P = 0.002), and lymph node metastases (P = 0.010). Immunoexpression of MYSM-1 was significantly correlated with distant metastases (P = 0.004), overall survival (OS) (P < 0.001), and local recurrence (P = 0.001). High expression of Twist-1 was positively correlated with pT stage, Fuhrman grade, lymph node, distant metastases, age (P < 0.001), clinical stage (P = 0.002), the presence of sarcomatous change (P = 0.004), and tumor size (P = 0.008). Immunoexpression of Twist-1 was significantly correlated with distant metastases (P = 0.009), OS (P < 0.001), and local recurrence (P = 0.003). Conclusion: Overexpression of Twist-1 is an indication of poor prognosis in patients with RCC, whereas that of MYSM-1 is a marker of good prognosis.

      PubDate: Fri, 26 Feb 2016 08:03:22 GMT
  • Heterotopic respiratory mucosa of the uterine corpus

    • Abstract: 2016-01-30T14-28-14Z
      Source: Journal of Interdisciplinary Histopathology
      Sarala Ravindran, Jayalakshmi Pailoor, Poh Bee Hoon.
      A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm × 1 cm × 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM) was made. To our knowledge, this is the first reported case of HRM of the uterine corpus.

      PubDate: Sun, 24 Jan 2016 10:49:45 GMT
  • Primary mesenteric carcinoid tumor

    • Abstract: 2016-01-30T14-28-14Z
      Source: Journal of Interdisciplinary Histopathology
      Swati Aggarwal, Shubham Agarwal, Dilip Ramrakhiani.
      Mesenteric tumors are uncommon lesions. Primary mesenteric carcinoid is a rare entity with only a few reported cases. Therefore, a thorough examination of the resected bowel is necessary to rule out the presence of possible primary tumor in the adjacent bowel loop. We present a case of primary mesenteric carcinoid.

      PubDate: Sun, 24 Jan 2016 10:24:37 GMT
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