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Journal Cover Journal of Interdisciplinary Histopathology
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2146-8362
   Published by ScopeMed Homepage  [99 journals]
  • Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin
           Expression in Astrocytic glioma

    • Abstract: 2016-05-07T09-15-50Z
      Source: Journal of Interdisciplinary Histopathology
      Aziza E. Abdelrahman, Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, Abdel-Motaleb Mohamed.
      Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression and therapy resistance. Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters. Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed. Results: The cases included 10 low grade, 12 anaplastic and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (p < 0.001). Nestin was strongly correlated to survivin index (p < 0.001). The univariate analysis showed that high histological grade, high nestin score and high survivin index were significantly correlated with overall survival. Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (p = 0.011). Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor overall survival. Therefore, nestin and survivin could be used to predict high risk group of astrocytoma with unfavorable outcome.

      PubDate: Tue, 03 May 2016 23:37:02 GMT
  • Invasive Carcinoma of Breast with Adnexal Differentiation of Trichoblastic

    • Abstract: 2016-04-26T19-06-38Z
      Source: Journal of Interdisciplinary Histopathology
      Sarala Ravindran, Pathmanathan Rajadurai, Joshua Mohanraj Daniel, Yip Cheng Har.
      We present a rare distinctive variant of invasive carcinoma of breast characterized by adnexal differentiation of tumor of trichoblastic type. The neoplasm was identified in a mastectomy specimen from an 83-year-old Chinese woman. Morphologically, the trichoblastic differentiation was characterized by the formation of solid sheets and nests of basaloid cells. The tumor cells were positive for cytokeratin 5/6, BER-EP4, bcl-2, and β-catenin. Stromal cells were positive for CD10. The tumor cells exhibited a “triple negative” profile; the nuclei did not react with antibodies to estrogen and progesterone receptors but failed to show overexpression of the HER2/neu protein. The MIB-1 labeling index averaged 20%. It is hoped that this case increases awareness for this unique morphological variant of invasive ductal carcinoma.

      PubDate: Sun, 24 Apr 2016 07:50:20 GMT
  • C-kit (CD117) Expression Is Not Valuable to Predict Prognosis in Invasive
           Ductal Carcinoma of Breast

    • Abstract: 2016-04-06T20-37-17Z
      Source: Journal of Interdisciplinary Histopathology
      Maha Shomaf, Al-Motassem Yousef, Jamal Masad, Murad Sahawneh, Ahmad Halawa.
      Objective: C-kit functions as a tyrosine kinase receptor and represents a target for small molecule kinase inhibitors. The expression pattern for c-kit was studied in different human tumor types as gastrointestinal stromal tumor, malignant melanoma, breast and lung cancer, sarcoma and mastocytosis. C-kit expression in malignant tumors can be a factor that might affect the prognosis and its expression in different tumors was studied in respect of its correlation with the outcome. Imatinib or sunitinib therapy of KIT-positive tumors is an example of a targeted cancer therapy requiring immunohistochemical tumor analysis to identify patients that would benefit from this kind of therapy. This study is done on patients with breast cancer to find out the frequency of c-kit expression and to find out if it has any effect on the outcome of the patients and to compare the results with that of other ethnicities. Materials and Methods: Paraffin-embedded tumor tissues from 81 patients with breast invasive ductal carcinoma were analyzed immunohistochemically for c-kit expression and correlated to the survival of the patients after initial diagnosis using the follow-up data. Results: The mean age of the patients was 52.8 years. The median follow-up period was 22 months (range 1-37 months). C-kit immunopositivity was found in 37 cases (46%). Expression of c-kit was found in tumor samples with varying intensities and infrequently. Conclusion: There was no significant correlation between c-kit expression and prognosis.

      PubDate: Sun, 03 Apr 2016 06:23:52 GMT
  • Unaltered Stroma and Parenchymain in Vital Organs of Rat Models Following
           Administration of Low Dose of Carica Papaya Leaf

    • Abstract: 2016-04-06T20-37-17Z
      Source: Journal of Interdisciplinary Histopathology
      Felix M Onyije, Vivian C Zenebo, Julius K Bankole, kester A Digban, Godwin O Avwioro.
      Background: The use of Carica papaya leaves for medicines and food in our rural areas is rampant, this is due to its availability and testimonies of its efficacy. Objective: This study was aimed at investigating the activities of C. papaya on the histo-architecture of some organs. Materials and Methods: About 20 Wistar rats were randomly divided into 4 groups of 5 each and received tap water, 2.5, 5, and 7.5 g/kg of ethanolic extract of C. papaya PO once a day for 14 days after which biochemical analyses was performed on the blood samples. The tissues were examined histologically. Results: Albumin was significantly increased (37.6 ± 2.70) in Group B (5 mg/kg) when compared with the control (32.4 ± 2.30). AST decreased significantly in all the treatment groups (68 ± 1.58, 87.4 ± 403, and 89 ± 1.58) when compared with the control (93.6 ± 1.14). ALT decreased in all groups but was significant in Group C (7.5 mg/kg) 22.8 ± 2.16 when compared with the control (30 ± 2.12). Urea decreased significantly in all the groups (3.34 ± 0.11, 3.78 ± 0.50, and 3.36 ± 0.28), creatinine decreased significantly in Group B (35.4 ± 2.79) when compared to their controls (4.52 ± 0.37 and 50.8 ± 6.37), respectively. Na+ and K+ significantly decreased in Groups C and B, respectively; there was no significant difference in other groups and electrolytes. There was increased level of both packed cell volume and hemoglobin significantly. Histologically, there were no tissue alterations in all the treatment groups. Conclusion: Complementary and alternative medicine is fast gaining popularity; this necessitates swift research on various dose ranges.

      PubDate: Sat, 02 Apr 2016 10:42:01 GMT
  • Prognostic Implication of MYSM-1 and Twist-1 in Renal Cell Carcinoma

    • Abstract: 2016-03-02T09-17-51Z
      Source: Journal of Interdisciplinary Histopathology
      Ola Harb, Abdelmonem Hegazy, Maged Ali, Rasha Haggag.
      Objective: The data available regarding the epithelial-mesenchymal transition (EMT) markers are little. This study aimed to evaluate the immunohistochemical expression of EMT markers; MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 in renal cell carcinoma (RCC), in a trial to find their role in the prognosis of such type of cancer. Methods: Immunoexpressions of MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 were assessed in tissue specimens of 50 patients with RCC, and correlated with other clinicopathological features. The findings and their correlations were statistically determined. Results: Low expression of MYSM-1 was negatively correlated with size of the tumor, primary tumor (pT) stage, Fuhrman grade (P < 0.001), age (P = 0.002), and lymph node metastases (P = 0.010). Immunoexpression of MYSM-1 was significantly correlated with distant metastases (P = 0.004), overall survival (OS) (P < 0.001), and local recurrence (P = 0.001). High expression of Twist-1 was positively correlated with pT stage, Fuhrman grade, lymph node, distant metastases, age (P < 0.001), clinical stage (P = 0.002), the presence of sarcomatous change (P = 0.004), and tumor size (P = 0.008). Immunoexpression of Twist-1 was significantly correlated with distant metastases (P = 0.009), OS (P < 0.001), and local recurrence (P = 0.003). Conclusion: Overexpression of Twist-1 is an indication of poor prognosis in patients with RCC, whereas that of MYSM-1 is a marker of good prognosis.

      PubDate: Fri, 26 Feb 2016 08:03:22 GMT
  • Heterotopic respiratory mucosa of the uterine corpus

    • Abstract: 2016-01-30T14-28-14Z
      Source: Journal of Interdisciplinary Histopathology
      Sarala Ravindran, Jayalakshmi Pailoor, Poh Bee Hoon.
      A 47-year-old, single, Chinese woman presented with pain on the 1st day of menses for more than 30 years. Her dysmenorrhea worsened over years and underwent a total abdominal hysterectomy and bilateral salpingooophorectomy. The myometrium showed trabeculated appearance, and there were adhesions between ovaries and fallopian tubes. A pale solid brownish mass measuring 1.5 cm × 1 cm × 0.6 cm with fibrous whitish cut surfaces was present on the lateral wall of the uterus in the lower uterine segment. Histologically, adenomyosis and left ovarian endometriosis were confirmed. The lateral uterine wall nodule showed a tubular structure lined by ciliated pseudostratified columnar epithelium. Smooth muscle bundles were found around the entire tubular structure. Lobules of salivary type glands containing both serous and mucous cells are present. The pathological diagnosis of heterotopic respiratory mucosa (HRM) was made. To our knowledge, this is the first reported case of HRM of the uterine corpus.

      PubDate: Sun, 24 Jan 2016 10:49:45 GMT
  • Primary mesenteric carcinoid tumor

    • Abstract: 2016-01-30T14-28-14Z
      Source: Journal of Interdisciplinary Histopathology
      Swati Aggarwal, Shubham Agarwal, Dilip Ramrakhiani.
      Mesenteric tumors are uncommon lesions. Primary mesenteric carcinoid is a rare entity with only a few reported cases. Therefore, a thorough examination of the resected bowel is necessary to rule out the presence of possible primary tumor in the adjacent bowel loop. We present a case of primary mesenteric carcinoid.

      PubDate: Sun, 24 Jan 2016 10:24:37 GMT
  • Large Multiloculated Splenic Mesothelial Cyst: A Rare Case Report

    • Abstract: 2015-12-24T20-34-50Z
      Source: Journal of Interdisciplinary Histopathology
      Roumina Hasan, Anuradha Ck Rao, Sandeep Kumar, Sushmitha Malpe Gopal, Neha Jain.
      The mesothelial splenic cyst is a rare clinical entity, comprising

      PubDate: Wed, 23 Dec 2015 00:06:01 GMT
  • Testicular Toxicity and Sperm Quality Following Exposure to
           Solignum®: A Permethrin-Containing Wood Preservative in Adult Male
           Wistar Rats

    • Abstract: 2015-11-29T23-16-46Z
      Source: Journal of Interdisciplinary Histopathology
      Kingsley Chukwuemeka Patrick-Iwuanyanwu, Nnaemeka Arinze Udowelle, Chioma Joy Okereke.
      Background: Permethrin is widely used as a pesticide in agriculture, homes, gardens, and for treatment of ectoparasites such as fleas, lice, and scabies on human and animals. The aim of the present study was to evaluate the testicular toxicity and sperm quality of adult male Wistar albino rats exposed to Solignum® (SOL), a commercial permethrin-containing wood preservative. Materials and Methods: A total number of 32 adult male Wistar albino rats were divided into four groups of eight rats per group. SOL mixed with olive oil (1:1) was orally administered to rats daily at concentrations of 100, 200, and 400 mg/kg for 28 days while the control received 1 ml of olive oil only. At the end of this study, animals were sacrificed and testes excised, weighed, and processed for histological examination. Results: Rats treated with SOL showed a significant (P ≤ 0.05) decrease in body weight ranging from 127.30 ± 5.95 to 84.50 ± 15.37 g as compared with control group (138.50 ± 6.7 g). Absolute testicular weight, relative testicular weight, and epididymis together with testes decreased significantly (P ≤ 0.05) in treated rats ranging from 0.63 ± 0.44 to 0.22 ± 0.18; 0.49 ± 7.39 to 0.26 ± 1.17, and 1.07 ± 0.75 to 0.37 ± 0.19, respectively, when compared with control groups (0.89 ± 0.27; 0.64 ± 4.00; and 1.40 ± 0.35) for absolute testicular weight, relative testicular weight, and epididymis together with testes, respectively after 28 days. However, there was a significant (P ≤ 0.05) decrease in sperm count, sperm motility, sperm morphology, and sperm viability, whereas sperm debris increased significantly (P ≤ 0.05) in a dose-dependent manner when compared with control group. Furthermore, histological examination of the testes indicated that rats exposed to SOL were characterized by significant degenerative changes when compared with control group. Conclusion: Therefore, exposure to SOL may inhibit spermatogenesis, impair fertility, and generally, have toxicological concerns in the male reproductive system.

      PubDate: Thu, 26 Nov 2015 15:25:19 GMT
  • Solid Epithelioid Hemangioma of the Heart: Report of a Case with Unusual
           Thread-Like Bridging Strands

    • Abstract: 2015-11-29T23-16-46Z
      Source: Journal of Interdisciplinary Histopathology
      Jan Koren, Michal Zamecnik.
      We present a rare case of solid epithelioid hemangioma (EH) which was found in the left atrium of the heart in a 77-year-old man. The tumor measured 20 mm. Histologically, it was composed of a solid proliferation of epithelioid endothelial cells. Some cells contained intracytoplasmic lumina with the appearance of vacuoles. Focally, several of such cells, closely adjacent to one another, created small vascular space with thin transverse bridge of cytoplasm, resembling strongly so-called threadlike bridging strands which are typical of adenomatoid tumor. Therefore, the adenomatoid tumor was considered in differential diagnosis of this lesion. However, immunohistochemical expressions of CD31 and ERG protein, and negative results with mesothelial markers confirmed endothelial nature of the tumor. Cardiac EH with solid pattern and with threadlike bridging strands is extremely rare lesion which should not be confused with the adenomatoid tumor.

      PubDate: Thu, 26 Nov 2015 14:07:42 GMT
  • Paratesticular Liposarcoma of the Spermatic Cord-A Rare Case

    • Abstract: 2015-11-14T23-17-59Z
      Source: Journal of Interdisciplinary Histopathology
      Sushma Shankar, Bhaskaran Ashokan, Muni Reddy, Hemalatha Anantharamaiah.
      Spermatic cord liposarcomas (LPS) are rare representing 7% of paratesticular sarcomas. The most present as slow growing inguinal or scrotal masses that need to be differentiated from inguinal hernias, testicular tumors, hydrocele, and benign lipomas. A 57-year-old male presented with right scrotal swelling since 1 year that grew rapidly in last 4 months. On examination, a firm, nontender mass was felt in the right scrotum measuring 12 cm × 8 cm. A clinical diagnosis of right testicular tumor was made. Ultrasound scrotum large, heteroechoeic mass separate from right testis. Magnetic resonance imaging scrotum well-defined, homogenously enhancing extra testicular mass with fat component' Paratesticular lipoma/liposarcoma. Right radical orchiectomy, high ligation of spermatic cord, and excision of mass en bloc were performed. Gross findings: Multiple, globular, gray yellow, firm masses seen in the paratesticular area and spermatic cord, the largest measuring 11 cm × 7 cm × 5 cm. Testis, epididymis-normal. Cut surface–solid, yellowish white with myxoid areas. Microscopy-mature adipocytes of varying sizes separated by dense fibrillary fibrocollagenous stroma with pleomorphic, bizarre stromal cells, and multinucleate giant cells. Interspersed areas showed extensive mast cell infiltration and myxoid change. Diagnosis, well-differentiated liposarcoma/atypical lipomatous tumor sclerosing type of paratesticular area (spermatic cord). Paratesticular LPS of spermatic cord are rare tumors often misdiagnosed clinically resulting in incomplete excision and high recurrences. This report highlights the need of considering liposarcoma as a differential diagnosis in inguinoscrotal masses and stresses the role of histopathological examination in making a definitive diagnosis, which cannot be established clinically/radiologically.

      PubDate: Wed, 11 Nov 2015 01:21:46 GMT
  • A Comparative Study of Oral Hamartoma and Choristoma

    • Abstract: 2015-10-31T00-22-27Z
      Source: Journal of Interdisciplinary Histopathology
      Ilana Kaplan, Irit Allon, Benjamin Shlomi, Vadim Raiser, Dror M. Allon.
      Aim: To compare the clinical and microscopic characteristics of hamartoma and choristoma of the oral mucosa and jaws and discuss the challenges in diagnosis. Materials and methods: Analysis of patients diagnosed between 2000-2012, and literature review of the same years. A sub-classification into "single tissue" or "mixed- tissue" types was applied for all the diagnoses according to the histopathological description. Results: 61 new cases of hamartoma or choristoma were retrieved, the majority were hamartoma. The literature analysis yielded 155 cases, of which 44.5% were choristoma. The majority of hamartoma were mixed. Among these, neurovascular hamartoma was the most prevalent type (36.7%). Of the choristoma, 59.4% were single tissue, with respiratory, gastric and cartilaginous being the most prevalent single tissue types. The tongue was the most frequent location in both groups. Conclusion: Differentiating choristoma from hamartoma depends to a great extent on the recognition of the normal tissues expected at every individual location.

      PubDate: Fri, 30 Oct 2015 12:44:29 GMT
  • Cystic Sclerosing Stromal Tumor of the Ovary: A Case Report and Review of

    • Abstract: 2015-10-22T04-28-25Z
      Source: Journal of Interdisciplinary Histopathology
      Geetha Vasudevan, Arijit Bishnu.
      Sclerosing stromal tumour of the ovary is an uncommon benign ovarian neoplasm of sex cord stromal origin with distinct clinical and radiological features. We describe a cystic SST in a 35 year old female who presented with right lower abdominal pain. CT-scan revealed a complex ovarian cyst. Right sided Salpingo-oophorectomy was done with intra-operative frozen section which ruled out malignancy. Histopathology showed features consistent with SST ovary. In this report we discuss the differential diagnosis and role of histopathology in confirming the benign nature of the neoplasm,so a conservative surgery can be performed.

      PubDate: Tue, 20 Oct 2015 01:27:55 GMT
  • Characterization of HER2 Gene/Protein and Ki67 Protein Expressions in
           Colorectal Carcinoma Variants With Relation To Clinicopathological
           Parameters and Prognosis: An Immunohistochemical and Fluorescence In Situ
           Hybridization Study

    • Abstract: 2015-10-11T23-18-27Z
      Source: Journal of Interdisciplinary Histopathology
      Abd Al-Rahman Mohammad Foda, Eman Abdelzaher, Iman Talaat.
      Objective The data on the frequency and pattern of HER2 expression in colorectal carcinoma (CRC) and its clinical signifi¬cance are ambiguous. In addition, little is known about HER2 status in CRC variants and its relation with proliferative activity and clinical outcome. Such knowledge may be of potential value for therapeutic decision making in CRCs. Methods The HER2 gene/protein status was assessed by fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) in a tissue microarray of 150 CRCs and correlated with the expression of the proliferation marker Ki67, clinicopathological factors, and prognosis. Results CRCs were categorized into conventional adenocarcinoma (CA), 47 cases; adenocarcinoma with mucinous component (AMC), 28 cases; mucinous adenocarcinoma (MA), 56 cases; and signet ring cell carcinoma (SRCC), 19 cases. Compared to other variants, CA was significantly associated with favorable clinicopathological features, higher overall survival (OS) and disease-free survival (DFS), while SRCC and MA were significantly associated with ominous clinicopathological features, lower OS and DFS. Cytoplasmic HER2 overexpression was detected in 14.2% of CRC cases and showed a significant agreement with gene amplification. HER2 overexpression was significantly associated with favorable clinicopathological features notably early stages. High Ki67 expression was detected in 48% of CRC cases. HER2 and Ki67 were significantly different among CRC variants with AMC showing the greatest frequency of HER2 overexpression and Ki67 high expression than the other variants. The interrelation between HER2 and Ki67 expression was statistically insignificant and neither had any significant relation to OS or DFS in any of the CRC variants. Conclusions We conclude that mucinous histology infers an adverse prognosis in CRC. A subset of early stage CRC patients, with HER2 overexpression and possibly a distinct variant, may benefit from HER2 targeted therapy. IHC can be used as a method for screening of HER2 gene amplification in CRCs.

      PubDate: Thu, 08 Oct 2015 00:20:03 GMT
  • Immunohistochemical Expression of COX-2 in Uterine Serous Carcinoma Tissue

    • Abstract: 2015-10-11T23-18-27Z
      Source: Journal of Interdisciplinary Histopathology
      Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy.
      Objective. The aim of the present study was to assess Cox-2 expression in uterine serous carcinoma (USC) tissue, to correlate it with clinicopathological prognostic factors in order to assess whether selective Cox-2 inhibitors may be effective in the treatment in this tumor. Material and methods. Cox-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014. Staining of more than 10% of the cells was considered positive. Staining intensity was graded on a 0–3 scale. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Clinicopathological data were retrospectively abstracted from the records of the study group patients Results. The study comprised uterine specimens of 31 USC patients. Positive immunohistochemical staining was observed in 25 (80.6%) USC specimens and a high score in 6 (19.4%) of them. No association between immunohistochemical staining parameters and clinicopathological prognostic factors was observed. Conclusion. Although our findings should be verified in larger series, it seems that in view of the lack of association between immunohistochemical Cox-2 staining parameters in USC tissue and clinicopathological prognostic factors, this aggressive tumor is not a candidate for the use of selective Cox-2 inhibitors. Key words: Cox-2 expression, uterine carcinosarcoma, clinicopathological prognostic factors

      PubDate: Wed, 07 Oct 2015 07:26:10 GMT
  • Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is
           Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update)

    • Abstract: 2015-10-06T23-18-24Z
      Source: Journal of Interdisciplinary Histopathology
      Ayhan Ozcan.
      Renal cell carcinoma (RCC) is the third most common cancer of the genitourinary tract and accounts for approximately 2-3% of all cancer deaths. The recent classification of renal tumors, The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia, has been proposed new distinct epithelial tumors and provisional new entities. Although most renal tumors are morphologically diagnosed, they need to use a panel of immunomarkers due to their overlapping morphologic features in some cases such as benign mimickers and newly emerged tumor types. Overlapping morphologic features are especially complicated in small biopsies and in distinguishing metastatic RCCs from other tumors. Immunohistochemistry is still more useful in renal tumors than non-renal tumors. A wide panel has been performed in the differential diagnosis of renal tumors. If immunohistochemical results are conflict or unconvincing, a diagnosis of unclassified RCC is appropriate. For accurate diagnosis of RCC, it should be careful in performing immunohistochemistry on needle biopsy due to variable expressions of immunomarkers originated from heterogeneity in RCCs. Morphology is still gold standard, but immunohistochemistry should be kept in mind as a useful and supportive diagnostic tool upon morphological features of renal tumors as always.

      PubDate: Tue, 06 Oct 2015 08:02:40 GMT
  • Tubo-ovarian Actinomycosis Mimicking Ovarian Malignancy: Case Report

    • Abstract: 2015-08-23T17-30-27Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Maroua Bouhamed, Ghada Sahraoui, Saadia Bouraoui, Ahlem Lahmar, Sabeh Mzabi-Regaya.
      Actinomycosis is a chronic suppurative granulomatous infection caused by Actinomyces israelii, an anaerobic Gram-positive microorganism. Pelvic actinomycosis is rare and constitutes 3% of all human actinomycosis infections. Pre-operative diagnosis is usually difficult with the majority of cases being diagnosed after the histological and bacteriological examination of the resected specimen. In this paper, the authors report a new case of tubo-ovarian actinomycosis in a 42-year-old woman that was misdiagnosed pre-operatively as ovarian malignancy. Tubo-ovarian actinomycosis should be considered in patients with a pelvic mass especially in ones using intra-uterine devices. Surgeons should be aware of this infection in order to avoid excessive surgical procedures.

      PubDate: Wed, 19 Aug 2015 13:21:25 GMT
  • A Retrospective Study on Qualitative Assessment of Copper Content in Oral
           Leukoplakia, Submucous Fibrosis and Squamous Cell Carcinoma with Rhodamine

    • Abstract: 2015-07-24T20-31-55Z
      Source: Journal of Interdisciplinary Histopathology
      Priya Shirish Joshi, Bhagyalaxmi Praveen Hongal, Neha Shashank Agnihotri, Rutuja Shridhar Kempwade.
      Background: Trace elements are required in small concentrations as essential active components of biological enzyme systems. They are in the form of metalloenzymes and copper is one such component. Copper metabolism is profoundly altered in neoplastic disease. Copper plays an important role in tumor angiogenesis especially in early stages and is also necessary for endothelial cell activation. Copper content in tissues of oral leukoplakia (OL), oral submucous fibrosis (OSMF), and oral squamous cell carcinoma (OSCC) has not been studied extensively. Hence, we attempted this retrospective study to analyze copper content in the tissues by using rhodamine stain for better understanding of pathogenesis. Aim and Objectives: To evaluate and compare the copper content and its depth of penetration in tissue sections of diagnosed cases of oral precancer and cancer by using rhodamine staining method. Materials and Methods: This retrospective analytical study was conducted on histologically diagnosed 10 cases each of OL, OSMF, and OSCC. Ten cases of normal mucosa served as control. The selected cases were subjected to staining with rhodamine for qualitative analysis of copper content. Results: Paired t-test showed a significant increase in copper content in the study group (P = 0.516) as compared to control group. Krushall–Wallis non-parametric test showed higher mean value of copper content in cases of OSMF (2.00) than the cases of OL (1.20) and OSCC (1.70). Conclusion: Copper content by rhodamine staining technique was found to be higher in OSMF than OL and OSCC this staining technique can be used as a prognostic indicator for assessment of disease progression.

      PubDate: Wed, 22 Jul 2015 07:12:13 GMT
  • A Rare Finding of Coexisting Fibroadenoma and Duct Ectasia in Axillary
           Ectopic Breast Tissue

    • Abstract: 2015-07-24T20-31-55Z
      Source: Journal of Interdisciplinary Histopathology
      Sunita Singh, Hemant Yadav, Divya Srivastava, Rajeev Sen.
      Ectopic breast tissue (EBT) can present anywhere along the milk line from axilla to groin. It can harbor all the pathological conditions as that of the normal breast though incidence is very low. Fibroadenoma is rare in accessory breast and only a few cases have been reported in the literature. Here, we report a 30-year-old female presented with a firm and freely mobile right axillary lump measuring 6 cm × 4 cm. Fine-needle aspiration cytology revealed it as accessory breast tissue. However, the excision biopsy of the same showed fibroadenoma along with duct ectasia in EBT. This case has been reported due to its rarity and for consideration of fibroadenoma in differential diagnoses of axillary swellings.

      PubDate: Tue, 21 Jul 2015 07:10:47 GMT
  • Sirenomelia – Mermaid Syndrome with Oesophageal Atresia: A Rare Case

    • Abstract: 2015-07-19T19-02-21Z
      Source: Journal of Interdisciplinary Histopathology
      Veena Raja, Vidyavathi Kannar, C. S. Babu Rajendra Prasad.
      Sirenomelia or Mermaid syndrome is a very rare congenital deformity in which legs are fused together and commonly associated with abnormal kidney development, genital, and rectal abnormalities. In this present case, sirenomelia was associated with oesophageal atresia, which is a rare association and occurs in about 20-35% of cases.

      PubDate: Sat, 18 Jul 2015 10:21:14 GMT
  • Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma

    • Abstract: 2015-07-19T19-02-21Z
      Source: Journal of Interdisciplinary Histopathology
      Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy.
      Objective: To compare tissue immunohistochemical expression of CA125 with its level in the serum of corresponding uterine serous carcinoma (USC) patients. Materials and Methods: Paraffin-embedded tissue blocks of consecutive USC uterine specimens of 25 patients with known serum CA125 levels prior to treatment were examined. The clinicopathological records of these patients were retrospectively abstracted. Immunohistochemistry was performed in each case on deparaffinized 4μ sections of paraffin-embedded tissue blocks for detection of CA125. Staining of more than 10% of cells was considered positive. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Results: Positive immunohistochemical staining and a high staining score were found in 72.0% and 61.1% of the patients respectively elevated serum CA125 levels prior to treatment were observed in 36.0% of the patients. The difference between the percentage of USC patients with positive CA125 tissue staining and the percentage of those with elevated CA125 serum levels were significant. Elevated serum levels correlated significantly with advanced stage disease. No correlation was found between positive immunohistochemical tissue staining parameters and stage of the disease. Conclusion: The higher proportion of USC patients with positive CA125 immunohistochemical tissue staining than with elevated serum CA125 levels indicates the presence of some mechanism that prevents the access of CA125 into the circulation.

      PubDate: Fri, 17 Jul 2015 02:15:49 GMT
  • Schistosomiasis: A Rare Cause of Acute Appendicitis

    • Abstract: 2015-05-22T14-21-16Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Saadia Bouraoui, Maroua Bouhamed, Ghada Sahraoui, Ahlem Lahmar, Sabeh Mzabi.
      Schistosomiasis is a water-borne trematode infestation and is one of the most widespread parasitic diseases in the world. Schistosomiasis can affect any organ, but is rare in the appendix. In this paper, the authors report a new case of appendicular schistosomiasis that was incidentally discovered in a 27-year-old male patient from Mali who underwent appendectomy for acute appendicitis. Appendectomy specimens removed from patients with appendicular schistosomiasis often appear macroscopically normal, but histopathological analysis of these cases confirms the diagnosis by revealing schistosomal eggs. The authors strongly recommend that all appendectomy specimens be examined histopathologically regardless of whether the specimens are macroscopically normal.

      PubDate: Tue, 19 May 2015 23:33:18 GMT
  • Bilateral Adenomyoepithelioma of the Breast Presenting With Breast Abscess
           in a Lactating Woman: A Case Report

    • Abstract: 2015-04-28T23-26-27Z
      Source: Journal of Interdisciplinary Histopathology
      Manna Valiathan, Padmapriya Jaiprakash, Geetha Vasudevan.
      The term adenomyoepithelioma has been applied to a broad range of biphasic lesions composed of epithelial and myoepithelial cells. They show diverse morphologic patterns due to the admixture of the two components which may lead to a diagnosis of malignancy. We present a case of bilateral adenomyoepithelioma in a lactating woman who had a concomitant breast abscess. A 25-year-old lady presented with bilateral breast lumps since 2 years, with acute pain. With a clinical diagnosis of an abscess, superimposed on fibrocystic disease, drainage of abscess, and lumpectomy was performed. The clinicopathological features of this entity are discussed.

      PubDate: Mon, 27 Apr 2015 06:45:22 GMT
  • A preventable complication of a slow growing cancer – Lessons learned
           and a literature review

    • Abstract: 2015-04-28T23-26-27Z
      Source: Journal of Interdisciplinary Histopathology
      Alethea Tan, Parneet Gill, Haitham Kashaba, Sally Hales, Fahmy Fahmy.
      Malignant tumors of the hand are rare. Chondrosarcoma presenting in the hand are usually low grade with low risk of metastasis. To our knowledge and following literature review, there are nine reported cases of metastatic chondrosarcoma of the hand worldwide in the English literature, with only two reported cases of axillary lymphadenopathy. We describe a case of an unusual presentation of chondrosarcoma of the left little finger with distant axillary and pulmonary metastases. We also review management issues unique to this patient and reflective learning points to improve care. Our patient could have had a satisfactory outcome if treated early. We recommend referral of suspicious hand lesions to a specialist hand surgeon, for early assessment and management, in order to reduce patient morbidity and mortality.

      PubDate: Sat, 25 Apr 2015 00:41:48 GMT
  • Effects of Menopause and Diabetes on the Rat Thyroid Gland: A
           Histopathological and Stereological Examining

    • Abstract: 2015-04-18T23-31-59Z
      Source: Journal of Interdisciplinary Histopathology
      Zeliha Yetim, Deniz Unal, Selina Aksak Karamese, Tolga Mercantepe, Jale Selli, Elif Polat, Basak Buyuk.
      Objective: Menopause is described as the arrest of the menstruation cycle and ending of reproductive potential. Diabetes mellitus (DM) occurs with Type 1 diabetes that is originated from the absence of insulin and Type 2 diabetes depending on insulin resistance. It is one of the most common endocrine disorders encountered in clinical practice that can cause serious health complications. Therefore, the objective of the present thesis was to investigate the effects of menopause and diabetes upon the thyroid using a rat model. Materials and Methods: 24, 12 weeks old female Sprague-Dawley rats were divided randomly into; non-diabetic healthy control group (Group I, n = 6), diabetic group (Group II, n = 6), ovariectomy group (Group III, n = 6), and ovariectomy plus diabetic group (Group IV, n = 6), respectively. Results: In histopathological examinations, the thyroid gland of the diabetic group had large follicles with cuboidal or almost squamous epithelial lining surrounding wide lumen. There were areas of disorganized follicles with decreased colloid. In the ovariectomized (OVX) rats, there was hyperplasia of the thyroid follicles and disorganized follicles with complete obstruction of their lumina. Mitotic cells were available. Some parafollicular cells had lack of cytoplasm. Post ovariectomy diabetes-induced group (Group IV), there were some species between follicles and remarkable reduction of colloid. Hyperplasia of the thyroid follicles, solid cell nests, and mitotic cells were also seen increasingly in this group. Follicular lumen area of ovariectomy group is closer to the control group. The increase of the lumen area in the DM group was the largest, diabetes+ovariectomy group also had an increase in the follicular lumen area. Conclusion: Finally; postmenopausal aging and diabetes in rats, may cause thyroid degeneration. DM and menopause both cause oxidative stress. But their damages on thyroid tissue are different. It means they cause oxidative stress via different ways. DM + OVX group compared to other groups has the greatest damage.

      PubDate: Wed, 15 Apr 2015 05:26:38 GMT
  • Intraosseous Schwannoma

    • Abstract: 2015-04-14T04-32-24Z
      Source: Journal of Interdisciplinary Histopathology
      Bhavna Nayal, Ranjini Kudva, Sandeep Kumar, Rajesh Parameshwaran Nair, Ashitha Nanaiah.
      Intraosseous schwannomas are rare and benign neoplasms originating from the nerve sheath cells. We present two such cases, one located in the ninth thoracic vertebrae and the other involving the sacrum. Clinicoradiological diagnosis in both the cases was a primary bone tumour. Histopathological examination revealed characteristic morphology of schwannoma which was confirmed by immunohistochemistry. These two cases highlight the importance of clinical, radiological and histopathological correlation in the diagnosis of these uncommon bone tumors.

      PubDate: Mon, 13 Apr 2015 12:47:20 GMT
  • Collagenous Gastritis: A Rare Entity

    • Abstract: 2015-03-18T20-13-22Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Sabeh Mzabi.
      Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the stomach. Biopsies of the duodenum and colon were unremarkable. However, biopsies of the gastric fundus revealed a mild chronic gastritis characterized by lymphocytic and plasma cell infiltration of deep mucosa, without lymphoid follicle formation or active inflammation. No microorganisms were identified on routine hematoxylin and eosin or Giemsa-stained sections. Subepithelial collagen in the gastric biopsies was thickened and showed entrapped capillaries. Subepithelial collagen was highlighted by Masson’s trichrome staining and was negative for amyloid by Congo Red. In the areas containing thickened collagen, there were no intraepithelial lymphocytes. The final pathological diagnosis was collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic and pathologic findings to make a correct diagnosis. Specific therapy for this rare entity has not yet been established.

      PubDate: Wed, 18 Mar 2015 12:03:16 GMT
  • Gene Therapy and Stem Cells in the Treatment of Congenital Diseases.

    • Abstract: 2015-03-10T05-00-54Z
      Source: Journal of Interdisciplinary Histopathology
      Paula Rubya Souza Câmara.
      Several congenital diseases are particularly attractive candidates for intervention using gene therapy since the underlying molecular bases for most of the monogenic disorders are well-understood. Transplantation of ex vivo genetically modified stem cells has also shown promise. Although all of these systems are meritorious and worthy of continued investigation, this mini-review article focused on the platforms that have received the most attention and that are maturing in the clinical setting; in particular, the potential of in vivo gene therapy and human-induced pluripotent stem cells. Studies of apparently disparate diseases that are presumably linked through shared metabolic pathways are likely to provide greater insights into the biology of the diseases. This and other opportunities for exchange will hopefully foster acceleration in the development of new and innovative therapies for these devastating diseases.

      PubDate: Sat, 07 Mar 2015 10:01:41 GMT
  • Synchronous Superficial Myofibroblastoma and Stromal polyp of the Vagina:
           Report of A Case Supporting Common Histogenesis of Both Lesions

    • Abstract: 2015-03-05T04-32-38Z
      Source: Journal of Interdisciplinary Histopathology
      Michal Zamecnik, Roman Sucansky.
      Rare simultaneous occurrence of vaginal superficial cervicovaginal myofibroblastoma and vaginal stromal polyp is described. The lesions were found in a 90-years-old patient, in the anterior wall of the vagina. The diameter of the lesions was 6cm and 2cm, respectively. Between them, a 3cm part of normal appearing vaginal wall was present. Both lesions showed similar myoid appearing morphology and myofibroblastic desmin+/actin-/h-caldesmon-/CD34- immunophenotype, with positivity for CD10, CD99, estrogen receptor and progesterone receptor. Larger lesion was diagnosed as benign cervicovaginal myofibroblastoma, and the smaller one had typical features of vaginal stromal polyp. This case of simultaneous occurrence of cervicovaginal myofibroblastoma and vaginal stromal polyp supports previously suggested histogenetic relationship between these lesions.

      PubDate: Wed, 04 Mar 2015 05:26:39 GMT
  • Overview of the Last Two Years

    • Abstract: 2015-03-05T04-32-38Z
      Source: Journal of Interdisciplinary Histopathology
      Ayhan Ozcan.

      PubDate: Wed, 04 Mar 2015 04:13:36 GMT
  • Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on
           Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Neveen Mohamed El-sherif, Noha Mohy Issa.
      Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group), Group II (NA treated group) received NA at a dose of 200 mg/kg/day dissolved in 5 ml/kg corn oil orally by gastric tube, Group III (protected group) received rosemary extract (10 ml/kg/day) followed after 60 min by NA at the same previous dose orally by gastric tube. The experiment lasted 30 days. The following parameters were studied: Biochemical assessment of renal function, histological, immunohistochemical, morphometric studies and statistical analysis of the results. Results: NA treatment resulted in a highly significant increase in the mean values of serum urea and creatinine. NA induced histological changes in the form of glomerular congestion. Some glomeruli demonstrated marked mesangial expansion and hence that Bowman’s spaces were almost completely obliterated. Shrinkage of renal glomeruli with widening of Bowman’s spaces could also be seen. Focal tubular dilatation with appearance of casts inside the tubules was observed. Congested peritubular blood vessels and interstitial hemorrhage were also seen. The medullary region demonstrated vascular congestion and fibrosis. Focal cellular infiltration was presented in the interstitium. The renal cortex of NA treated rats showed a noticeable down regulation in alkaline phosphatase positive immunoreactive cells in some proximal convoluted tubules. NA induced up regulation of positive immunoreaction for inducible nitric oxide synthase in the proximal and distal convoluted tubules as well as in the collecting tubules. All previous results were significantly reversed in the protected group compared with NA treated group. Conclusions: It is concluded that NA has a harmful effect on rat kidney. Rosemary extract had a protective role against renal injury induced by NA and this effect may be attributed to its antioxidant and anti-inflammatory activity.

      PubDate: Fri, 20 Feb 2015 11:52:51 GMT
  • Appendiceal Hyperplastic Polyp: Case Report

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Saadia Bouraoui, Maroua Bouahmed, Ghada Sahraoui, Ahlem Lahmar, Sabeh Mzabi-Regaya.
      Serrated lesions morphologically analogous to those seen in the colorectum are found in the appendix. Appendiceal hyperplastic polyps are very rare, and their true incidence is unknown. A 52-year-old male previously healthy patient with no particular past medical history, presented with a 24-h history of abdominal pain localized to the right lower quadrant. On physical examination, he was tender to palpation in the lower right quadrant. As acute appendicitis was highly suspected, laparoscopic appendectomy was performed. Histological examination of the surgical specimen showed acute inflammation of the appendiceal wall. The crypts were focally elongated but relatively straight with serrations that were visible mainly near the luminal end of the crypts. Columnar cells with or without apical mucous vacuoles alternated with large goblet cells. The crypt bases were not serrated and were lined by regular cells with small nuclei. The muscularis mucosa was intact. The postoperative course was uneventful, and the patient was discharged on postoperative day 1. The final pathological diagnosis was acute appendicitis associated with hyperplastic polyp. Hyperplastic lesions of the appendix are often incidental findings although they can be associated with acute appendicitis. They are significantly associated with adenocarcinoma elsewhere in the large intestine and the finding of mucosal hyperplasia in an appendectomy is an indication for further investigations to exclude colorectal neoplasia.

      PubDate: Tue, 17 Feb 2015 00:00:15 GMT
  • Granular Cell Tumor of the Breast: An Unusual Tumor of the Breast
           Masquerading As Malignancy

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Padmapriya Jaiprakash, Kanthilatha Pai.
      Granular cell tumor (GCT) is a rare neoplasm of the breast, accounting for

      PubDate: Mon, 16 Feb 2015 23:24:50 GMT
  • Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat

    • Abstract: 2015-02-05T04-32-32Z
      Source: Journal of Interdisciplinary Histopathology
      Neveen M. El-Sherif, Abeer E. El-Mehi.
      Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compared with other consumers. Objectives: This study was performed to throw light on the effect of SEM on the testis of juvenile male albino rat. Materials and Methods: This study was carried out on 20 juvenile male albino rats divided into the control group, and SEM treated group. Animals of the SEM treated group were administered 40 mg of SEM orally once daily for 30 days. At the end of the experiment, animals were weighed and then sacrificed. The parameters examined were gonadal index, epididymal spermatozoal examination, histological study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in addition to ultrastructural study. Morphometric study and statistical analysis of the results were carried out. Results: The gonadal index of SEM treated group showed a significant decrease compared with the control group. Loss of germ cells was confirmed by a significantly low sperm count. SEM induced variable degrees of tubular affection in the form of distorted seminiferous tubules, cellular disorganization, sloughing and cytoplasmic vacuolation. Acidophilic hyaline material, vacuolations, and congested blood vessels were present in most of the interstitial spaces. Immunohistochemically, SEM treatment induced a marked reduction in the number of PCNA immunoreactive cells. An ultrastructural alteration of spermatogenic cells and wide separation in between germ cells were observed. Conclusions: These results suggest that growing animals are more susceptible to gonadal toxicity of SEM. It is better to avoid food products sold in glass jars, especially during the juvenile period.

      PubDate: Mon, 02 Feb 2015 13:25:19 GMT
  • Spectrum of Intestinal Neoplasms: A study of 400 cases

    • Abstract: 2015-01-11T13-13-38Z
      Source: Journal of Interdisciplinary Histopathology
      Aminder Singh, Bhavna Garg, Neena Sood, Harpreet Kaur Puri, Vikram Narang, Sumit Grover.
      Objective: The present study is a five-year analysis of all the tumors of small and large intestine received in the Pathology Department of Dayanand Medical College and Hospital, Ludhiana. Methods: All the cases were grossly and microscopically examined and were staged according to Astler Coller Staging and classified and subtyped according to WHO classification. The important differences between the small and large intestine tumors were also analyzed. Results: There were 400 cases out of which 356 were in large intestine while 44 were in the small intestine. There were only 56 benign neoplasms while 344 were malignant tumors. Adenomas were the most common benign tumors while majority of malignant tumors were adenocarcinomas. Lymphomas, mesenchymal tumors, and carcinoid tumors were much more common in a small intestine as compared to large intestine. Majority of adenocarcinomas were located in the large intestine with most of them being moderately differentiated having Astler Coller Stage B II. Mucinous carcinomas had the worst prognosis as compared to adenocarcinomas. Anal canal had mainly squamous cell carcinomas. Conclusions: Tumors of large intestine were much commoner than of small intestine. There was a higher incidence of tumor in males with M:F ratio of 2.2:1. Mean age of presentation of benign tumor was younger, i.e., 32.6 years when compared to 54.5 years for malignant tumors. Tubular adenoma was the most common benign tumor and adenocarcinoma the commonest malignant neoplasm.

      PubDate: Sat, 10 Jan 2015 10:59:57 GMT
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