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Journal Cover Journal of Interdisciplinary Histopathology
   [3 followers]  Follow    
  This is an Open Access Journal Open Access journal
     ISSN (Print) 2146-8362
     Published by ScopeMed Homepage  [77 journals]
  • Warfarin Related Nephropathy and Beyond. What Renal Pathologists Need To
           Suspect in A Kidney Biopsy.

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergey V Brodsky, Anjali A Satoskar, Tibor Nadasdy.
      We have recently described a new clinical syndrome in patients receiving warfarin for anticoagulation. First, we identified that warfarin therapy can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients. This syndrome has been named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly susceptible. We defined WRN as an acute increase in INR to greater than 3.0, followed by evidence of AKI (defined as a sustained increase in serum creatinine of greater than or equal to 0.3 mg/dl) within a week of the INR increase. We believe that anticoagulant-related kidney injury should be suspected in a patient on an anticoagulation therapy, if there is a disproportion between the number of RBC tubular casts, ATN and the degree of an underlying kidney lesion (such as glomerular immune complex depositions, GBM thickness abnormalities etc) in kidney biopsy. Detailed evaluation of coagulation data and medications is recommended for all patients with RBC casts and AKI.

      PubDate: Thu, 07 Aug 2014 23:33:05 GMT
       
  • Arterial and Arteriolar Lesions in Renal Allografts: A Differential
           Diagnostic Approach

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Anjali A Satoskar, Sergey V Brodsky, Gyongyi M Nadasdy, Tibor Nadasdy.
      Renal allograft pathology is quite a complex issue and has been addressed in many monographs and book chapters. Renal allografts can fail secondary to rejection, but recurrent renal diseases and de novo diseases affecting the allograft may also contribute to the demise of the transplanted kidney. As a pathologist, one needs to examine the four compartments of the kidney (glomeruli, tubules, interstitium, and vasculature) separately and integrate the histology with the clinical presentation. Although glomerular and tubulointerstitial changes can be quite relevant in terms of renal allograft outcome and prognosis, correct evaluation of arterial/arteriolar changes in a renal allograft is crucial in making the appropriate diagnosis and the arterial/arteriolar changes may provide relevant prognostic information. The pathologist should very carefully study and describe the vascular changes in a renal allograft and correlate them with clinical findings. If arteries are not present, or if only a single or two small terminal interlobular arteries are seen, the biopsy report should indicate this and draw attention to possible sampling errors and to limited informative value of the specimen. In this review, we will try to provide a short review on vascular changes in renal allografts with a differential diagnostic approach.

      PubDate: Wed, 09 Jul 2014 09:21:26 GMT
       
  • Low Grade Fibromyxoid Sarcoma of the Mesentery, an Under Recognised
           Entity: A Case Report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Geetha Vasudevan, Archana Shivamurthy.
      Low grade fibromyxoid sarcoma (LGFMS) is an indolent, rare soft tissue tumor having potential of late metastasis, but high local recurrence rate despite its low grade histologic findings. The morphologic diagnosis may be challenging, owing to its typically low cellularity, abundant collagen, and relatively bland cytology. We present here a rare case report of a mesenteric mass in an elderly male. The mass was excised. On microscopy, the tumor was composed of sweeping fascicles of spindle cells, which were positive for vimentin and negative for CD117, CD34, smooth muscle antigen and S-100. Herein we report a rare, under recognized case of LGFMS arising in the mesentery.

      PubDate: Wed, 25 Jun 2014 04:49:48 GMT
       
  • Managing Epiglottal Chondrosarcoma of a Dog: A case report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ahmed M Shoieb.
      A primary chondrosarcoma was found in the epiglottis of a 6-year-old, neutered, male Boxer cross-breed dog. Clinically, there was upper respiratory noise, and a 3.2 cm × 2.8 cm × 2.7 cm, ovoid mass involving the epiglottis was observed. No abnormalities were detected upon radiographic examinations (X-ray) of the chest or abdomen. Grossly, the excised mass was hard. On cut section, it displayed a lobular pattern of translucent gray-white color (interpreted as cartilage). Histologically, the epiglottal submucosa contained a non-encapsulated, fairly demarcated multi-nodular neoplasm composed of streams of cells admixed with moderate to abundant amounts of a pale amphophilic to eosinophilic matrix (chondroid). The neoplastic cells stained were immunohistochemically positive for vimentin and S-100 protein, and negative for pancytokeratin. The matrix stained deeply with Alcian Blue (pH 2.5)-periodic acid Schiff, which often separated cells into individual lacunae. To the best of our knowledge, this is the first report of extra-skeletal chondrosarcoma primarily arising in the epiglottis of a dog.

      PubDate: Wed, 25 Jun 2014 04:34:54 GMT
       
  • Isolated Juvenile Xanthogranuloma in Thoracic Spine: Intraoperative
           Cytological Diagnosis of a Rare Presentation

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Shashi Singhvi, Shruti Bhargava.
      Juvenile Xanthogranulomas (JXG) are benign proliferative disorders of non-Langerhans histiocytes, which present in children as multiple, self-limited, cutaneous lesions. The extracutaneous manifestations of JXG are uncommon, and isolated JXG involving the spinal column is extremely rare. We report here a case of isolated juvenile xanthogranuloma in thoracic spine correctly diagnosed intraoperatively on crush smear cytology and later confirmed by histopathological and immunohistochemical studies. This case report draws attention to the fact that isolated xanthogranuloma should be considered among possible diagnoses of spinal tumor in children. Also, since the long term survival depends on complete surgical resection, a correct intraoperative diagnosis is extremely important for optimal management and prognosis of the patient.

      PubDate: Mon, 16 Jun 2014 00:54:15 GMT
       
  • Giant Solid-Pseudopapillary Neoplasm of the Pancreas in a Child

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Nandeesh BN, Kanishka Das.
      Solid-pseudopapillary neoplasm of the pancreas (SPPNP) is a primary epithelial neoplasm of the exocrine pancreas with borderline malignant potential. The unusual features included the ‘giant’ size and the absence of metastases/ capsular or vascular invasion despite the large size and predominantly solid nature. At two years following complete excision, she is asymptomatic and the imaging shows no recurrence/metastases.

      PubDate: Sun, 08 Jun 2014 05:10:51 GMT
       
  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel
           Density (MVD)-Related Markers, and Clinicopathological Features in
           Colorectal Carcinoma

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou.
      Objectives: Intercellular adhesion mediated by claudin and cadherin/catenin complex is a prerequisite of epithelial integrity and differentiation and has been suggested to be frequently disturbed in cancers. Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in angiogenesis than pan-endothelial markers such as CD31. The aim of this study was to assess the relationship between these markers and clinicopathological features of colorectal carcinomas. Materials and Methods: Surgical specimens from 69 patients with colorectal cancer were immunostained for claudin-1, E-cadherin, β-catenin, endoglin and CD31. Results: Forty-six (66.7%), 67 (97.1%), and 67 (97.1%) of the tumors, expressed immunostaining for claudin-1, E-cadherin and β-catenin, respectively. A significant association was seen between claudin-1 and E-cadherin expression (p=0.002), as well with β-catenin (p=0.009). High β-catenin expression appeared to reduce the risk of poor outcome. Endoglin vessel expression was correlated significantly with vessel invasion (p

      PubDate: Tue, 27 May 2014 12:45:24 GMT
       
  • The Significance of Mast Cells and Eosinophils Counts in Surgically
           Resected Appendix

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ashwini Kolur, Ashok M Patil, Vaibhav Agarwal, Saeed Yendigiri, BB Sajjanar.
      Objectives: The mast cell remains an enigmatic cell, found resident in tissues throughout the body particularly in association with structures such as blood vessels and nerves. Various inflammatory disorders of the intestines, joints and lungs appear to be associated with an increase in mast cell numbers. The study was conducted on vermiform appendix. The present study was undertaken (1) to compare the mast cell and eosinophil counts in various layers of the appendix in various histopathological groups, and (2) to establish the relationship between the numbers of eosinophils and mast cells in the inflamed appendix. Materials and Methods: The material for study consisted of appendix specimens received for histopathological examination in the Department of pathology. A 5 year study was conducted, 3 years retrospective and 2 years prospective. Results: Out of 777 cases studied the incidence of appendicitis is high, in the first and second decades of life and slightly higher in females. Recurrent appendicitis was more common when compared to other inflamed appendices. Conclusions: Eosinophil counts in all the layers were very high in acute eosinophilic appendicitis compared to normal appendices. A higher mast cell count was seen in acute eosinophilic appendicitis and recurrent appendicitis. No correlation was found between mast cell and eosinophilic density. Our observations support the allergic theory of appendicitis rather than the obstructive theory.

      PubDate: Tue, 13 May 2014 22:34:06 GMT
       
  • Suprasellar Anaplastic Meningioma Masquerading As Craniopharyngioma: A
           Case Report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Eman Abdelzaher, Ahmed Farhoud.
      Anaplastic meningiomas are uncommon. We report the clinical, radiological and pathological features of an anaplastic meningioma in a young male Egyptian patient presenting as a suprasellar solid/cystic enhancing mass resembling a craniopharyngioma.

      PubDate: Fri, 18 Apr 2014 06:00:50 GMT
       
  • Does Clinical Staging and Histological Grading Show Parallelism In Oral
           Submucous Fibrosis' A Retrospective Study from an Indian City

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Manish Narayan, Dominic Augustine, Tina Jacob, Kumar Chandan Shrivastava, Deepti Shrivastava, Shylaja Narayan.
      Objectives: Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF). Methods: The study group comprised of randomly included 40 patients. A comparison between clinical staging (a method used to find out the stage of disease using tests which include physical examination) and histopathological grading (grading is a measure of the cell appearance in pathology) was done in each case. Fisher’s exact test was done to obtain statistical analysis. Results: Among 15 cases of clinically diagnosed stage I lesions, 4 (10%) were grade I, 6 (15%) were grade II and 5 (12.5%) were grade III. Among 23 cases of stage II lesions 6 (15%) were diagnosed as grade I, 7 (17.5%) as grade II, 7 (17.5%) as grade III and 3 (7.5%) as grade IV. Among 2 cases of stage III both were diagnosed as grade II respectively. Conclusions: There was no correlation between clinical staging and histopathological grading of oral submucous fibrosis. The test results were statistically not significant. (p=0.635) This may be due to difference in severity and extent of fibrosis in different parts of the oral mucosa.

      PubDate: Sat, 12 Apr 2014 10:06:53 GMT
       
  • Metastatic Esophageal Squamous Cell Carcinoma in the Kidney

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sunita Singh, Sonia Chhabra, Pansi Gupta, Shivani Malik, Megha Ralli, Padam Parmar.
      Metastases from esophageal cancers represent only 4.8 per cent of secondary renal tumors. The kidney is known to be the 4th or 5th most common visceral metastasis site of esophageal carcinomas. More than 50% of renal metastases typically show bilateral involvement. Solitary, unilateral renal metastasis is extremely rare. Therefore, the diagnosis of renal metastases is very difficult. We report a case of solitary unilateral renal metastases in an esophageal squamous cell carcinoma in a 66 year old man’s autopsy.

      PubDate: Sun, 16 Mar 2014 12:49:52 GMT
       
  • Intravascular Papillary Endothelial Hyperplasia (Masson’s
           Hemangioma) Presenting as Soft Tissue Mass in Left Scapular Region-An
           Unusual Presentation

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Meenu Gill, Ashima Batra, Deepika Jain, Veena Gupta, Rajeev Sen, Sumiti Gupta.
      Intravascular papillary endothelial hyperplasia (IPEH) or reactive vascular endothelial lesion is a rare benign condition and is also known as Masson’s hemangioma. It may appear as a primary or pure form developing in a distended vessel, or it can be associated with hemangiomas, pyogenic granulomas, or lymphagiomas. It is usually confined to the lumen of preexisting vessels or vascular malformations. Nearly all the lesions are intimately associated with a thrombus in various stages of organization. The main significance of IPEH is its clinical and histological resemblance to soft-tissue sarcoma and possible misinterpretation as such. We hereby report a case of IPEH clinically and radiologically misdiagnosed as soft tissue sarcoma, in a 47-year-old man, presenting as a soft tissue mass in the left scapular region.

      PubDate: Fri, 14 Mar 2014 06:21:17 GMT
       
  • Renal Biopsy for Research: An Overview of Russian Experience

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergei V. Jargin.
      Renal biopsy is a relatively safe procedure with a well-defined risk profile. A biopsy for research is one that is carried out without clinical indications purely for research purposes. Research biopsies often have a parallel clinical purpose, therefore requiring more tissue to be sampled. Research as a purpose of a renal biopsy presupposes informed consent. This review is discussing several publications from the past, but the problem is still with us: invasive procedures performed primarily for research sometimes of questionable reliability. In the author’s opinion, renal biopsy should always be performed according to clinical indications. If the patient gives consent to research on the renal tissue obtained for the diagnostic purposes, it can be done, provided that enough tissue remains for the diagnostics, and that Institutional Review Committee approves of the research project.

      PubDate: Thu, 13 Mar 2014 08:17:39 GMT
       
  • Survivin Expression in Renal Epithelial Tumors: It’s Usage in the
           Differential Diagnosis of Eosinophilic Renal Epithelial Tumors

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ayhan Ozcan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, Sukru Ozaydin.
      Objective: The differential diagnosis of renal tumors can be problematic due to overlapping morphologic features. The purpose of this study was to assess the potential contribution of survivin expression in the differential diagnosis and determination of therapy modalities of these tumors. Methods: This study consisted of 15 chromophobe (ChRCC), 15 clear cell (CCRCC) and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas. Sections were stained against survivin antibody. Results: PRCCs and CCRCCs showed diffuse and strong survivin expression. Survivin expression was strikingly prominent in type1 PRCCs and cystic CCRCCs. In CCRCCs, survivin expression was more pronounced in low grade areas than high grade and sarcomatoid areas. In ChRCC, survivin expression was more limited and weaker than that of oncocytomas and other malignant renal tumors. In non-neoplastic renal tissue, survivin expression was more pronounced in podocytes and atrophic tubules than other nephron parts. Conclusions: Our results suggested that survivin may helpful in the differential diagnosis of renal tumors despite limited number of our cases. Experimental studies have revealed that inhibition of survivin induces apoptosis and enhance radiosensitivity of RCC cells. Taken together, to be known the proportion of survivin expression in subtypes of renal tumors may contribute to determine new therapeutic strategies for RCCs. This needs to be proven in more wide series.

      PubDate: Thu, 13 Mar 2014 04:44:02 GMT
       
  • Anabolic Androgen-induced Intrahepatic Cholestasis Presented With Normal
           γ-Glutamyl-Transpeptidase

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Savvoula Savvidou, Asterios Gagalis, Ioannis Efstratiou, Athanasios Kalambakas.
      The indisputable hepatotoxicity of anabolic androgen steroids has already been well substantiated in the literature, eventhough the exact pathophysiologic mechanisms are still being elucidated. Androgen-induced liver injury presents primarily with acute intrahepatic cholestasis accompanied by markedly elevated cholestatic enzymes and diverse levels of aminotransferases. A case report of a young male with remarkable jaundice due to acute anabolic androgen-induced cholestasis is presented. Interestingly, γ-glutamyl transpeptidase remained normal throughout the patient’s diagnostic workup. Histopathology was indicative of pure, “bland” intrahepatic cholestasis with minimal inflammation but significant fibrosis. The patient was successfully treated with ursodeoxycholic acid and glucocorticosteroids. The significance of normal γ-glutamyl transpeptidase along with the histopathological findings and the possible pathophysiological mechanisms are finally discussed.

      PubDate: Mon, 10 Mar 2014 11:41:54 GMT
       
  • The Protective Effect of Curcumin versus Sodium Nitroprusside on
           Intestinal Ischemia/Reperfusion Injury

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Dalia M Saleh, Rania N Sherif.
      Objective: Intestinal ischemia/reperfusion (I/R) injury is a significant complication in abdominal vascular surgery. Various treatment modalities have been applied, however, the role of nitric oxide (NO) in this type of injury is still controversial. Aim of the work: To compare the protective effect of curcumin vs sodium nitroprusside (SNP, NO donor) on intestine and remote organs following intestinal I/R injury. Methods: Rats were divided into 4 groups (sham-control, I/R, curcumin+I/R, SNP+I/R). I/R was induced by 30 min clamping the superior mesenteric artery (SMA) then 60 min reperfusion. Rats were pretreated with either curcumin (80 mg/kg/day) with food for one week or SNP (5 mg/kg, i.p) prior to I/R. Intestinal levels of malondialdehyde (MDA), Nitrite/nitrate, superoxide dismutase (SOD) and reduced glutathione (GSH) were measured. The sections from jejunum, lungs and liver were stained with hematoxylin and eosin (H&E) for histopathological examination. Immunohistochemical stains for eNOS expression in the jejunum and cleaved caspase-3 for apoptosis in the lungs and liver were done. Results: I/R resulted in both local and remote organs inflammation associated with significant increase in MDA and nitrate/nitrite and significant decrease in SOD and GSH levels. These histological and biochemical changes were improved by pretreatment with curcumin and to less extent by SNP. Immunohistochemical examination showed significant decrease in eNOS activity in the I/R group which was improved by curcumin pretreatment not by SNP. Liver apoptosis was improved by curcumin while lung apoptosis was improved by SNP. Conclusion: Curcumin ameliorates I/R-induced local and remote organs damage through its anti-inflammatory and antiapoptotic effect. SNP may be beneficial in I/R injury but not as significant as curcumin.

      PubDate: Mon, 03 Mar 2014 02:12:54 GMT
       
  • Analysis of the First Year Publishing Experience and the Future Goals

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ayhan Ozcan.


      PubDate: Thu, 27 Feb 2014 09:02:40 GMT
       
  • Giant Congenital Cerebriform Melanocytic Nevus of the Scalp in Adult

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Shashikala Krishnamurthy, Kavita GU, Shamila Mohamed Ali, Nagaraj Parvatappa.
      Congenital melanocytic nevi are defined as benign nevomelanocytic proliferation present at birth. They are rare lesions and occur in approximately 1% of new-borns and are usually classified according to their size. We report a case of 32 year old female who presented with a giant cerebriform lesion of the scalp which was present since birth. Diagnosis of Giant congenital melanocytic nevi was made on the basis of definite histological criteria. Wide excision of the lesion was done with split skin graft. This case is unique due to the fact that this young female lived with this disfiguring lesion for 3 decades and never consulted any physician for cosmetic purpose and fortunately the lesion never turned malignant.

      PubDate: Thu, 27 Feb 2014 05:20:03 GMT
       
  • Cytologically Diagnosed Ovarian Carcinoma Turned Out To Be a Case of
           Chronic Ectopic Pregnancy

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Snehamay Chaudhuri, Saikat Datta, Prabir Chandra Paul, Sumana Mukherjee, Samaresh Malo.
      Background – The diagnosis of chronic ectopic pregnancy is often difficult as there is a shortage of literature in which this disease is diagnosed as an entity separate from the condition of acute ecopic pregnancy. Experience with fine needle aspiration cytology in chronic ectopic pregnancy is not reported previously. Case - A 29-year-old para 3 woman presented with lower abdominal pain and irregular menstruation since two months Transvaginal ultrasonography showed a well defined heterogenous, solid-cystic right adnexal mass with normal serum beta HCG , and mildly elevated CA 125 level . Fine needle aspiration cytology from the mass suggested possibility of serous cyst adenocarcinoma. Abdominal hysterectomy with bilateral salpingo-oophorectomy and infra-colic omentectomy was done. Pathological findings were consistent with chronic ectopic pregnancy. Conclusion –It is possible to retrieve trophoblastic cells through fine needle aspiration even after 2 months of tubal rupture and this experience can be utilized to diagnose chronic ectopic pregnancy preoperatively.

      PubDate: Tue, 25 Feb 2014 12:45:31 GMT
       
  • Congenital Pouch Colon: A Rare Variant of Anorectal Malformation:
           Histopathological Perspective with Brief Review of Literature

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Dhiraj B Nikumbh, Kishor Suryawanshi, Sudhir Singhavi, Poonam Pagare, Akshay Surana.
      Congenital pouch colon is an extremely rare variant of anorectal malformation (ARM) in which all or part of colon is replaced by a pouch like dilatation that communicates distally with the urogenital tract by a large fistula. Congenital pouch colon differs from normal colon structurally, histologically and functionally. The incidence of congenital pouch colon among all cases of anorectal malformation in northern India has been reported to be between 5-10%. Rest of the India and around the globe handful of documented case reports was noted. The mortality from congenital pouch colon has decreased from 40% to 15%, if identified and managed properly. Herein, we report a case of 10 days male child presented with congenital pouch colon in view of a rare congenital anomaly. We enlighten the detailed histopathological findings in this case as there is paucity of literature of congenital pouch colon.

      PubDate: Mon, 24 Feb 2014 22:09:50 GMT
       
  • Extraovarian Primary Peritoneal Carcinoma: A Clinicopathological Gray Zone
           

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Kajal Basavaraj Punyashetty, Anand Anantharao Shankar, Trupti Vyasrao Katti.
      Extraovarian primary peritoneal carcinoma (EOPPC) is a rare disease entity, arising from extra ovarian peritoneum with abdominal carcinomatosis, uninvolved or minimally involved ovaries and no identifiable primary. Since an overlap of clinical manifestations and histologic appearances of EOPPC and papillary serous ovarian carcinoma exists, various diagnostic modalities like cytology, tumor markers, gross and histomorphological features, collectively help in arriving at a definitive diagnosis. As very few cases have been reported in literature, we hereby document one such interesting case.

      PubDate: Mon, 17 Feb 2014 21:57:08 GMT
       
  • Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral
           Cortex and Hippocampus

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Hagar A Hashish.
      Objective: Topiramate is a recent antiepileptic agent approved for treatment of seizure in adults, children and during pregnancy. No much available reports concerning topiramate teratogenic potential in humans. This could be explained by limited number of pregnancies exposed. Very few reports are available on animal experimentation with controversial results. This work aimed to clarify the histopathologic effects of prenatal topiramate exposure on the cerebral cortex and the hippocampus of newborn rats. Material and methods: 12 female pregnant rats were divided into control and treated groups, 6 rats in each group. The treated group was given topiramate dissolved in tap water, from day 0 of pregnancy till the delivery, through oral route in dose of 200mg/kg. The control group received tap water at the same time. In the end of the treatment, the cerebral cortex and the hippocampus were stained with hematoxylin and eosin (H&E) and immnunohistochemically for glial fibrillary acidic protein (GFAP). Results: The control rat cerebral cortex showed that granule cells were small cell with dense cytoplasm, pyramidal cells appeared with triangular cell body, light cytoplasm and small nucleus. Strong GFAP positive immunostaining was detected in the astrocytes in both granule cell and pyramidal cell layers. The pyramidal cells in Cornu Ammonis showed characteristic palisade arrangement, with lightly stained cytoplasm and central nucleus. Granule cells of the dentate gyrus were rounded, packed, dense. Strong GFAP positive immunostaining was detected in the astrocytes in both pyramidal cell and granule cell layers. In treated rats, granule and pyramidal cells in the cerebral cortex and hippocampus were disorganized with signs of degeneration. Faint GFAP positive immunostaining was detected in the astrocytes in granule and pyramidal cell layers. Conclusion: Long-term daily use of topiramate during pregnancy can lead to noticeable pathological neurotoxic effect in the cerebral cortex and hippocampus which may be implicated in cognitive affection. Neurological effect of topiramate necessitates further investigations.

      PubDate: Sun, 02 Feb 2014 09:05:52 GMT
       
  • Primary Well Differentiated Squamous Cell Carcinoma of Kidney: A Rare
           Entity

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sunita Singh, Meenu Gill, Ashima Batra, Shruti Semwal, Aarzoo Jahan, Rajeev Sen.
      Cancers of the kidney and renal pelvis are the ninth most common malignant cancer and form the 12th most common cause of all cancer-related deaths. Among malignant renal tumors, squamous cell carcinoma is rare neoplasm and form only about 0.5–8%. We present a case of 60 years old male with complaints of pain in the loin and hematuria for past 2 months. The patient underwent nephrectomy for renal mass on ultrasonography (USG) and computerized tomography (CT) scan, which turned out to be squamous cell carcinoma on histopathological examination.

      PubDate: Wed, 29 Jan 2014 13:20:25 GMT
       
  • Chernobyl-related Bladder Lesions: New Interpretation Required

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergei V. Jargin.
      Some aspects of practical pathology in the former Soviet Union, having a potential impact on the diagnostic quality, as well as possible mechanisms of false-positive diagnostics of malignant and premalignant lesions after the Chernobyl accident were discussed previously. In particular, overdiagnosis appears probable in regard to the bladder lesions detected in the radio-contaminated areas. Some studies on the post-Chernobyl bladder lesions are valuable but require new interpretation.

      PubDate: Tue, 28 Jan 2014 01:45:02 GMT
       
  • Unusual Locations of Hydatidosis: Cryptorchid Testicle and Peritoneum

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Faten Limaiem, Sirine Bouslama, Rached Bayar, Sana Ben Slama, Ahlem Lahmar, Saadia Bouraoui, Sabeh Mzabi.
      Hydatid cyst is a parasitic infection due to the larval stage of the tapeworm Echinococcus. It most commonly involves the liver and lung. Location at unusual sites in the body can have atypical presentations and poses a diagnostic challenge. Herein, the authors report a new case of hydatid disease involving the peritoneum and the tunica vaginalis of a cryptorchid testicle in a 57-year-old patient. They conclude that hydatid disease should be kept in mind when a cystic lesion in encountered in the testicle or the peritoneum in endemic areas.

      PubDate: Mon, 20 Jan 2014 22:53:19 GMT
       
  • IgG4-related Disease of the Genitourinary Tract

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Mukul K. Divatia, Jae Y Ro.
      IgG4-related disease (IgG4-RD) is a recently established albeit well recognized fibro-inflammatory condition with distinctive features including a characteristic histopathological appearance; a propensity to develop tumefactive lesions in multiple body sites; and oft elevated serum IgG4 levels. The consensus statement on IgG-4 RD equips practicing pathologists with a set of working guidelines for the diagnosis of pathologic lesions identified in a host of different organ system affected with this disease. The diagnosis of IgG4-RD requires the combined presence of the characteristic histopathological appearance and increased numbers of IgG4-positive plasma cells. The essential histopathological features include a dense lymphoplasmacytic infiltrate, a storiform pattern of fibrosis, and obliterative phlebitis. Tissue IgG4-positive plasma cell counts and IgG4: IgG ratios are significant ancillary aids in establishing the diagnosis. The spectrum of IgG4-RD continues to expand and involve multiple body sites. The genitourinary system comprising of the kidneys, ureters, urinary bladder, urethra, prostate gland, testes and penis is one of the multiple organ systems to be affected by IgG4-RD. This review describes the clinical and histopathologic patterns of involvement of the genitourinary system by IgG4-RD, in association with serologic and radiological features.

      PubDate: Thu, 26 Dec 2013 00:47:14 GMT
       
  • Sublethal Dose of Diazinon Induces Pulmonary Toxicity in Rat:
           Histopathological Evidence

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Gholamreza Najafi, Ali Asghar Tehrani, Ali Shalizar Jalali, Mohammad Babaei, Ali Najafi.
      Objective: Diazinon (DZ) is a widely used contact organophosphorous pesticide with broad spectrum insecticide activity. The extensive use of DZ has caused great concern due to the hazardous side effects on human beings as well as wild and domestic animals. The aim of this study was to investigate the effect of sublethal dose of DZ on rat lung. Material and methods: Seven groups of male Wistar rats were used comprising control and test groups. The control group received corn oil (0.3 ml/day) for 60 days by oral gavages. The test groups received DZ at a dose of 60 mg/kg body weight orally for 2, 10, 24, 30, 54 and 60 days, respectively. Results: The histopathological analysis of the lungs in DZ-treated groups revealed congestion on day 2, pulmonary edema and emphysema on day 10, congestion and atelectasia on day 24, infiltration of mononuclear cells on day 30 and pulmonary hemorrhage along with bronchial glands hyperplasia on days 54 and 60. DZ administration also caused a significant decrease in serum cholinesterase activity in a time-dependent manner. Conclusion: These findings indicate that sublethal dose of DZ can induce severe lesions in the lung of rat.

      PubDate: Tue, 24 Dec 2013 10:25:13 GMT
       
  • Metastasis of Follicular Variant of Papillary Thyroid Carcinoma to Scalp,
           Masquerading As Adnexal Tumor: A Rare Presentation

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Basavaraj Prabhappa Bommanahalli, Shashikala Krishnamurthy P, Linganagouda Patil.
      ABSTRACT A 55-year-old female presented with ulcerated swelling over the scalp. Clinically, the case was diagnosed as adnexal tumor of skin. Fine needle aspiration cytology (FNAC) from the lesion showed characteristic micro-follicles with typical nuclear features of papillary thyroid carcinoma. Later, diligent clinical examination revealed a small thyroid nodule and FNAC from the same, showed similar cytomorphological features, indicating possibility of follicular variant of papillary thyroid carcinoma. Biopsy of the scalp swelling and thyroid nodule confirmed the same. Identification of typical nuclear features in cytology helps in differentiating follicular variant papillary carcinoma from follicular neoplasms and, predominant presence of microfollicles favour follicular variant of papillary thyroid carcinoma (FVPTC). Spread through lymphatic route is common in papillary thyroid carcinoma but haematogenous dissemination leading to cutaneous metastases is rare. A solitary cutaneous lesion may be the first evidence of disseminated malignancy in a patient with occult papillary thyroid carcinoma. KEY WORDS: Follicular variant; Papillary thyroid carcinoma; Fine Needle Aspiration Cytology; Adnexal tumor

      PubDate: Thu, 05 Dec 2013 06:46:23 GMT
       
  • Effects of administration of Melatonin on the harderian gland of sheep

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Enas Ahmed Abd ElHafez, Alaa Sayed Abou-elhamd, Ahmed Hassan Hassan.
      The objective of this study was to study the morphological structure of the harderian gland of sheep by using light and electron microscopy and to study the effect of melatonin administration on the secretory activity of the gland. This experiment was performed on fifteen Soay rams aged 1.5 years. Results revealed that the harderian gland of sheep was of compound tubuloalveolar type. By using light microscopy, the secretory end-pieces of the harderian gland of sheep were lined with principal and basal cells. The principal cells showed different secretory activities. After melatonin administration, the PAS and aclian blue reactivity in the epithelial lining of the harderian gland was increased.

      PubDate: Sun, 15 Sep 2013 00:35:57 GMT
       
  • False Immunohistochemical Results for Herpesviridae and Other Clusters of
           Differentiation Due To Biotin Intranuclear Inclusions in the Gestational
           Endometrium

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Francesco Rivasi, Luca Roncati, Giuseppe Barbolini, Elisabetta Petrella, Renzo Boldorini.
      Objective. There are now eight known human herpes viruses (HHV) containing a double-stranded DNA genome: Herpes Simplex Virus 1 (HSV1, HHV1), Herpes Simplex Virus 2 (HSV2, HHV2), Varicella-Zoster Virus (VZV, HHV3), Epstein-Barr Virus (EBV, HHV4), Cytomegalovirus (CMV, HHV5), Herpes Virus 6 (HHV6-a, HHV6-b), Herpes Virus 7 (HHV7) and Herpes Virus 8 (HHV8, KSHV - Kaposi’s sarcoma associated herpes virus). The highest risk of maternal-fetal HSV transmission is among women who acquire a genital infection during pregnancy. Congenital HHV6 infection occurs in 1% of births, a rate similar to that for CMV infection. Congenital HHV6-a infections are asymptomatic, whereas postnatal HHV6-b infections present with acute febrile states. The purpose of this study was to eliminate false positive results in order to achieve an accurate pathological diagnosis for herpes virus infections to the gestational endometrium. Methods. The biopsies of three suspected cases of gestational herpetic endometritis were submitted to immunohistochemical tests for HHV1+2, HHV5, HHV6-a, HHV6-b, HHV8 and for other clusters of differentiation (CD4, CD8, CD20) in compliance with the ABC method protocol. Samples from the three cases under study were submitted to a real-time polymerase chain reaction (PCR). Results. All three cases exhibited false intranuclear immunohistochemical positivity to the antibodies being used. Conversely, all three reactions tested negative with biotin inactivation. The PCR for herpesviridae, which was positive in the known herpetic controls, showed negative in all three cases. Conclusions. Immunohistochemical investigations of the gestational endometrium (particularly in pregnancies near to term) may yield false results for several herpes viruses, as well as for other immunohistochemical reactions obtained using the ABC method without prior biotin inactivation.

      PubDate: Sat, 14 Sep 2013 16:19:54 GMT
       
  • A Case of Brucellosis Associated with Histiocytic Necrotizing
           Lymphadenitis: A Diagnostic Pitfall.

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Nicole Dalton Wheeler, Marian Rollins-Raval, Steven H. Swerdlow, Swati Modi, Kimberly Liang, Robyn T. Domsic, Kathleen R. Sheridan.
      Human cases of brucellosis are rare in the United States and difficult to diagnose. We report a case of a young female who underwent a diagnostic investigation of fever of unknown origin, which included a lymph node biopsy. The biopsy was consistent with Kikuchi’s Disease, or histiocytic necrotizing lymphadenitis, an entity where the major differential diagnosis is systemic lupus erythematosus. Interestingly, serologic studies supported the diagnosis of brucellosis. Brucellosis has rarely been associated with histiocytic necrotizing lymphadenitis. This association has never been reported in the United States, thus suggesting that brucellosis should be considered in the differential for histiocytic necrotizing lymphadenitis, along with lupus-like autoimmune disease. As the prognosis and treatment of histiocytic necrotizing lymphadenitis, brucellosis, and systemic lupus erythematosus are distinct, it is important to differentiate these entities.

      PubDate: Wed, 24 Jul 2013 22:51:54 GMT
       
  • Primary Cervical Placental Site Trophoblastic Tumor: A Rare Entity with an
           Unusual Presentation

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Kanthilatha Pai, Pratap Kumar, Akhila Vasudeva.
      Placental site trophoblastic tumour (PSTT) is the least common form of gestational trophoblastic neoplasia accounting for only 1-2% of trophoblastic tumors. Approximately 200 cases are reported in English literature. PSTT presenting as a cervical growth is even less common. Differentiation of PSTT from other types of GTN, non-neoplastic gestational trophoblastic disease and non-trophoblastic tumors is important clinically due to differences in their therapeutic approaches.Appreciation of the morphologic features and immunophenotype allows their accurate diagnosis.Although most of the cases of PSTT behave in a benign fashion,the clinical behavior of PSTT can sometimes be variable and several prognostic factors can help to predict the biological behavior of this condition. We report a rare case of placental site trophoblastic tumor, presenting as a cervical mass, in a 38 year old female, and review the literature.

      PubDate: Tue, 23 Jul 2013 07:26:27 GMT
       
  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an
           HIV-Infected Patient on Antiretroviral Therapy

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse.
      Liver disease in HIV-infected patients is complex and multifactorial. Drug toxicity and infections are common causes of elevations in liver-associated enzymes. Immune reconstitution and unmasking of autoimmune disease may also play a role, particularly in the era of effective combination antiretroviral therapy. In this case report, we describe the first reported biopsy-confirmed case of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome presenting in an HIV-infected patient following initiation of antiretroviral therapy.

      PubDate: Sun, 30 Jun 2013 23:17:09 GMT
       
  • A Rare Association of Multiple Hepatic Lesions: Case Report and Literature
           Review

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Faten Limaiem, Faten Gargouri, Inès Haddad, Saadia Bouraoui, Ahlem Lahmar, Sabah Mzabi-Regaya.
      Biliary hamartomas or von Meyenburg complexes are uncommon benign biliary malformations, which are considered as part of the spectrum of fibrocystic diseases of the liver due to ductal plate malformation. Development of intrahepatic cholangiocarcinoma is well described in these complexes. However, only 10 cases of hepatocellular carcinoma arising in association with von Meyenburg complexes have been described in the English-language literature to date. In this paper, the authors report a peculiar case of hepatocellular carcinoma occurring on a background of von-Meyenburg's complexes and solitary unilocular bile duct cyst. It is not clear whether development of hepatocellular carcinomas is an epiphenomenon unrelated to the precursor lesion or biliary hamartomas may progress to liver cancers. Further studies are mandatory so as to elucidate and consolidate this very rare association.

      PubDate: Wed, 29 May 2013 06:58:20 GMT
       
  • Renal Function Impairment and Associated Risk Factors among Human
           Immunodeficiency Virus Positive Individuals at Flege Hiwot Referral
           Hospital, Northwest Ethiopia

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Getachew Kahsu, Wubet Birhan, Zelalem Addis, Mulat Dagnew, Baye Abera.
      Abstract Objective: The aim of this study was to determine the prevalence of renal impairment and associated risk factors among human immunodeficiency virus positive patients. Methods: A comparative cross-sectional study was conducted among human immunodeficiency virus positive patients at Bahir Dar Felege Hiwot referral Hospital. Demographic and other data were collected using structured questionnaires. Body mass index, urine protein, CD4 count, hemoglobin, electrolyte, lipid profile, serum urea and creatinine were measured. Data was entered into EPI info version 3.5.1 and analyzed using SPSS version 16. Descriptive statistics was calculated and logistic regression models were used to investigate factors associated with renal impairment. Results: A total 307 human immunodeficiency virus positive patients, 153 highly active antiretroviral therapy naïve (who didn’t take highly active antiretroviral therapy) and 154 on highly active antiretroviral therapy were enrolled in the study. The mean (±SD) age of the participants was 34.69 (± 8.86) years and about 61% were females. The prevalence of renal impairment in highly active antiretroviral therapy naïve and on highly active antiretroviral therapy individuals was 30.1% and 12.9% respectively. Proteinuria was found in 17.9 % of the participant. Low CD4 count (Adjusted odds ratio= 24.11; (95% CI 11.06, 52.56) and being highly active antiretroviral therapy naïve (Adjusted odds ratio = 6.58; 95% CI 2.99, 14.47) showed significant association with the prevalence of renal impairment. Conclusion: This study showed a high prevalence of renal impairment in human immunodeficiency virus positive individuals with higher rates among highly active antiretroviral therapy naïve individuals. It also indicated the importance of assessing of renal function in human immunodeficiency virus positive individuals in general and in highly active antiretroviral therapy naïve and with low CD4 count in particular. Further cohort studies with larger sample size are also important to establish the prevalence rate of renal impairment.

      PubDate: Mon, 13 May 2013 03:10:26 GMT
       
  • Xanthogranulomatous Cholecystitis Masquerading As Gallbladder Cancer: A
           Diagnostic Dilemma

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Faten Limaiem, Beya Chelly, Sadri Ben Abid, Emna Boudabous, Ahlem Lahmar, Saadia Bouraoui, Sabeh Mzabi-Regaya.
      Xanthogranulomatous cholecystitis is an uncommon variant of chronic cholecystitis, characterized by marked thickening of the gallbladder wall and dense local adhesions that may be confused with a malignant process. In this paper, the authors report a new case of xanthogranulomatous cholecystitis in a 63-year-old female patient that was misdiagnosed per-operatively as gallbladder cancer and treated with extensive excision. The common imaging techniques are not always able to differentiate xanthogranulomatous cholecystitis from gallbladder cancer and the final diagnosis is usually established by histological examination of the resected specimen. This entity should be kept in mind in difficult cholecystectomy cases.

      PubDate: Sun, 12 May 2013 05:13:27 GMT
       
  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss.
      Objective: Amelotin (AMTN) is highly and selectively expressed by odontogenic epithelium-derived ameloblasts throughout the maturation stage of enamel formation. The protein is secreted and concentrated at the basal lamina interface between ameloblasts and the mineralized enamel matrix. Odontogenic tumors (OT) are characterized by morphological resemblance to the developing tooth germ. OT vary from slowly expanding, encapsulated tumors to locally aggressive and destructive lesions. The purpose of this study was to determine the expression profile of AMTN in benign odontogenic tumors and to correlate it with specific features of the lesions. Methods: Immunohistochemical staining for AMTN was performed on human ameloblastoma, ameloblastic fibroma (AF), ameloblastic fibro-odontoma (AFO), odontoma, adenomatoid odontogenic tumor (AOT) and calcifying cystic odontogenic tumor (CCOT). Results: Generally, ameloblastoma and AF did not stain for AMTN. A strong signal was detected in ameloblast-like layers of AFO and odontoma. Epithelial cells in AOT did not stain for AMTN, while calcifying areas of extracellular eosinophilic matrix were intensely stained. Interestingly, ghost cells present in odontomas and CCOT revealed variable staining, again in association with calcification foci. Conclusions: Amelotin expression was consistently detected in tumors presenting differentiated ameloblasts and obvious matrix deposition. Additionally, the presence of the protein in the eosinophilic matrix and small mineralized foci of AOT and calcification areas of ghost cells may suggest a role for AMTN in the control of mineralization events.

      PubDate: Sat, 11 May 2013 15:36:43 GMT
       
  • The Histopathological Effect of Sildenafil Citrate on Superior Colliculus
           of Adult Male Rat

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Amany Shams, Hagar Hashish.
      Objective: Preclinical and very limited clinical studies suggest that sildenafil may have therapeutic potential in selected neurological disorders. However, many neurological side effects of sildenafil have been reported. This work aimed to clarify the histopathological effect of sildenafil citrate on the superior colliculus (SC) of adult male albino rat. Material and methods: 24 adult male albino rats were used and divided into 4 groups. The first 3 groups were received respectively sildenafil citrate orally at doses 0.25, 0.70 and 1.43mg/kg body weight daily for 30 days while the 4th group was used as control. At end of the treatment, the superior colliculi were undergone light and electron microscopic investigation. Results: In the control group, superficial part of the SC has neural cells and myelinated nerve fibers. With least dose of sildenafil, the superficial part of SC revealed disturbance in neural tissue with dilated capillaries and vacuoles. Some neurons showed deeply stained nuclei shrunken cytoplasm. Some cells showed enlarged mitochondria and dilated endoplasmic reticulum. With medium dose of sildenafil, SC showed more disturbances; stripped myelin sheaths or widely separated myelin lamellae, dilated blood vessels with large vacuoles around them and many neurons with apoptotic criteria. However, maximum dose of sildenafil induced massive destruction of edematous neural tissue; invasion of the surface with massive blood vessels, marked decrease in thickness of myelin sheaths and the neural cells revealed degenerative and apoptotic changes. The mean number and size of cells revealed significantly progressive decrease in all treated rats with increasing doses of the drug. Conclusion: Long-term, daily use of sildenafil can lead to pathological effect in the superior colliculus which may be implicated in visual disturbance and this effect is dose dependent, so neurological effect of sildenafil necessitates further investigations.

      PubDate: Thu, 25 Apr 2013 09:01:40 GMT
       
  • Heme Oxygenase-1 Expresion in Gastric Mucosa and Liver after Burns:
           Preliminary Immunohistochemical Study

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Ganka Bekyarova, Maria Tzaneva, Minka Hristova.
      Objective: Generation of reactive oxygen metabolites (ROM) and oxidative stress are crucial in pathogenesis of thermal skin injury. Heat shock proteins such as HSP32 known as heme oxygenase-1 (HO-1) possesses antioxidant, anti-inflammatory, and vasodilative properties and play an important role in the protecting of tissues from several stresses. In this immunohistochemical study, we have assessed the constitutive expression of HO-1 in normal gastric mucosa and liver and tested the hypothesis that its expression in these tissues is upregulated in thermal skin injury characterized by increased production of ROMs and other pro-inflammatory mediators. We used malondialdehyde (MDA) as a marker of oxidative stress and tumor necrosis factor (TNF) α as a marker of inflammatory response in burn rat model. Methods: HO-1 expression in formalin-fixed sections was assessed by peroxidase anti-peroxidase immunohistochemistry using a polyclonal rabbit anti-HO-1 as primary antibody. TNF-α in plasma was quantified using enzyme-linked immunosorbent assay (ELISA) kit. Spectrometric method was used for plasma and tissue MDA assay. Results:Immunohistochemical staining revealed HO-1 expression in all groups. Staining scores for HO-1 in endothelial cells in both gastric mucosa and liver were increased with 32% (p

      PubDate: Sun, 21 Apr 2013 14:44:54 GMT
       
  • Synchronous Bilateral Clear Cell Carcinoma and Papillary Serous
           Cystadenocarcinoma of the Ovaries

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Bhavna Nayal, Mary Mathew, Lakshmi Rao, Bhawna Nagel, Pratap Kumar.
      The presence of synchronous bilateral ovarian malignancy with similar histology is well recognized. The presence of two tumours with different pathology in both the ovaries is extremely uncommon and pose a diagnostic and therapeutic challenge. Only one such case has been reported in a postmenopausal lady. We present second such case with synchronous presence of high grade serous and clear cell carcinoma in a premenopausal woman.

      PubDate: Mon, 25 Mar 2013 05:51:10 GMT
       
  • Revisiting the Pathological Evaluation of the Thoracic Aortic Aneurysm

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Antonio Manenti, Luca Roncati, Giuseppe Barbolini.
      Objective. The most recent molecular acquisitions about the pathogenesis of the thoracic aortic aneurysm permit to better understand also the morphological counterpart of this disease, where atherosclerosis is not the only factor involved. The cascade of pathological processes leading to the development of the thoracic aortic aneurysms is multifactorial. Methods. We have investigated five surgical specimens of aneurysms of the thoracic aorta, collected from patients without Marfan's disease or other related genetic syndromes. Histochemistry for elastic fibers and mucosubstances has been performed, following the standard staining protocols. Results. The elastolysis, which can be considered a starting process, involves all the tunica media and it is followed by the mucoid degeneration characterized by the deposition of basophilic mucopolysaccaridic substance. Finally, the overlap of classic atherosclerotic lesions is observed, inside the whole aortic wall. Conclusions. The development of a thoracic aortic aneurysm is a complex event, where different factors and processes are involved, other than the well-known atherosclerosis, which can finally appear the most evident aspect of the overt disease.

      PubDate: Mon, 25 Mar 2013 02:44:52 GMT
       
  • Multiple Plexiform Xanthomatous Tumor: A Rare Occurrence in a Young Girl

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Kanthilatha Pai, Poornima Baliga, Ramachandra Lingadakai, Sathish Pai.
      Abstract: Plexiform Xanthomatous Tumor (PXT) is a rare benign tumor occurring in the dermis and subcutis composed of xanthomatous cells arranged in a distinct plexiform pattern. This condition has been found to occur exclusively in males. A rare occurrence of multiple plexiform xanthomatous tumors in a young female clinically diagnosed as multiple neurofibromatoses is presented. Literature search revealed only one case of PXT reported in female, hence this case is presented for its rarity.

      PubDate: Mon, 18 Mar 2013 04:59:24 GMT
       
  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour
           of The Breast

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng.
      Objective: To determine the relationship between the degree of CD10 expression in the stromal cells of phyllodes tumour and tumour grading. Methods: A total of 61 cases of mammary phyllodes tumours over the past 11 years were searched from histopathology files, University Malaya Medical Centre. The paraffin blocks were retrieved and 4 μm thick slides were prepared and stained using an antibody against CD10 with the envision method. Fibroadenoma case was used as a control slide and breast myoepithelium as the internal control. Each stained slides was independantly and semiquantitatively analysed for the intensity and percentage of the stromal cells stained. The staining intensity was graded as negative (no staining), mild, moderate and strong if the staining was much weaker, slightly weaker and same intensity as that of the myoepithelium, respectively. The tumour was considered positive for CD10 if the staining intensity is moderate to strong in 20% or more of the stromal cells. Results: 21 (44.7%) of 47 benign phyllodes tumour, 5 (83.3%) of 6 borderline phyllodes tumour and all 8 cases (100%) of malignant phyllodes tumour showed positive expression for CD10 immunostain. Conclusions: There was a significant increase in CD10 expression in the stromal cells as the lesions progressed from benign to borderline and malignant phyllodes tumour.

      PubDate: Sun, 17 Mar 2013 23:51:41 GMT
       
  • Papuloerythroderma of Ofuji in A Young Adult

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Mary Mathew, Bhavna Nayal, Raghunath Narayanan Unni, C Balachandran.
      Papuloerythroderma of Ofuji (PEO) is an uncommon skin condition characterized by generalized itchy papular eruptions involving the entire body surface, sparing the major skin folds in the body along with peripheral eosinophilia often asssociated with an malignancy, infection or drug therapy. It usually affects the elderly and very few cases have been reported in young adults. We report a 31 year old male with PEO in the absence of an underlying inciting factor.

      PubDate: Mon, 25 Feb 2013 23:33:28 GMT
       
  • Nodule over Arm during Pregnancy: An Unusual Presentation of Filariasis.

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Usha Kumar Mahesh, Madhavrao Ratnakar Potekar.
      The aim of the article is to present a rare case of filariasis presenting as a nodule over arm in a pregnant lady which was diagnosed by fine needle aspiration cytology. Lymphatic filariasis is a major public health problem in India with most infections being caused by Wuchereria bancrofti. Clinical manifestations depend on the area of lymphatic involvement and the duration of infection. The present case is being presented because on clinical examination there was absence of adjacent enlarged lymph nodes, microfilariaemia or peripheral blood eosinophilia, so it was misdiagnosed as lipoma and only on cytological examination microfilaria of Wuchereria bancrofti was noted.

      PubDate: Sun, 24 Feb 2013 23:23:43 GMT
       
  • Pediatric Gastrointestinal Diseases in Nigeria: Histopathologic Analysis
           of 74 Cases

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Abudu, Emmanuel Kunle, Oyebadeyo, Tope Yinka, Inyang-Etoh, Emmanuel Columba.
      BACKGROUND: Children are vulnerable to a vast number of diseases including gastrointestinal disorders, which may be associated with life threatening complications that sometimes result in mortality especially if left untreated. OBJECTIVE: To establish the age and sex distribution of children in the study population as well as the histopathological characteristics of gastrointestinal diseases that occurred in those children who were aged 14years and below in Sagamu, Southwestern Nigeria. MATERIALS AND METHODS: Demographic data such as age, sex, and clinical summary of children in the study population were extracted from the medical records of Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State from January 2003 to December 2009. Based on this information, a review of paraffin embedded blocks and slides as well as histopathological reports of gastrointestinal diseases that occurred in those children aged 14years and below was undertaken at the Morbid Anatomy Department of the hospital. RESULTS: Seventy–four cases of gastrointestinal diseases were seen in children aged 14years and below. The majority (39.2%) of gastrointestinal diseases were accounted for by appendiceal lesions. Hirschsprung’s disease, intussusceptions, enterocolitis and jejunal atresia accounted for 29.7%, 10.8%, 6.8% and 4.1% of cases respectively. Adenocarcinoma of the intestine was the predominant gastrointestinal tumour, occurring in 5 out of 7 children. Two cases of non-Hodgkin lymphoma were also seen. The ages of the children ranged from 2 to 14 years, with a mean age of 8.6years and a peak age incidence of gastrointestinal disease in the 10-14year age group. Male children were more commonly affected with the exception of appendiceal lesions, which occurred more in females (M:F ratio= 1.6:1.0). Acute suppurative appendicitis was the most prevalent lesion of the appendix, occurring in 13 out of 29 appendiceal lesions. Moderately differentiated to poorly differentiated histological types were seen in the tumours- 3 adenocarcinomas and 2 mucinous carcinomas. Burkitt’s and Mucosal-associated types of non– Hodgkin lymphomas were the two histological types of lymphoma seen primarily in the stomach and small intestine respectively. CONCLUSION: Appendiceal lesion was the predominant paediatric gastrointestinal disease found in the study population with preponderance for female children. Adenocarcinoma was the most common gastrointestinal tumour found, while, Hirschsprung’s disease, intussusception, enterocolitis, jejunal atresia and non-Hodgkin lymphoma contributed to only a minority of the gastrointestinal diseases found in the study population.

      PubDate: Sat, 23 Feb 2013 06:34:48 GMT
       
  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using
           Feulgen Stain and Exfoliative Brush Cytology.

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Priya Shirish Joshi, Manasi Sandipak Kaijkar.
      Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common cancer worldwide and accounting for 90% of cancers of oral cavity. Tobacco abuse has been proved to be the major risk factor in the development of OSCC. Despite advances in surgery, radiation and chemotherapy, the five year survival rate for oral cancer has not improved significantly over the past several decades and it remains at about 50 to 55%. Cytobrush sampling is more frequently used nowadays for exfoliative cytology, since it maximizes the number of cells obtained, and facilitates their uniform distribution onto the microscope slide, thus probably improving sensitivity.Our study was therefore carried out to analyze the cytomorphometric features of cells obtained by cytobrush and stained with Feulgen stain from oral premalignant and malignant lesions and to find out whether these features could be used to detect dysplasia and malignancy in their early stages. Aims: To analyze the cytomorphological features of cells in smears of oral premalignant and malignant lesions obtained from exfoliative brush cytology using Feulgen stain and to assess the efficacy of the same in detecting dysplasia and malignancy. Methods: Our study comprised of clinically and histopathologically diagnosed sixty cases which were grouped into twenty cases each of tobacco users with lesions (Leukoplakia and Erythroplakia) (Group I); tobacco users without lesions (Group II); Oral squamous cell carcinoma (OSCC) lesions (Group III); and normal mucosa (Group IV). The epithelial cells from the lesion were collected with a cytobrush and smears were stained with Feulgen stain. The cells were measured using software for their nuclear area, nuclear diameter, cellular area, cellular diameter and nuclear to cellular area ratio (N:C). Results: The exfoliated cells showed similar alterations as those occuring in histopathological sections of premalignant and malignant lesions. The N:C ratio, mean nuclear area and diameter value was highest in Group III and lowest in Group IV. The mean cellular area and diameter was highest in Group IV and lowest in Group III. Tukey-HSD formula for pairwise comparison showed a significant difference in mean values of nuclear and cellular area and diameter and N:C ratio between all the groups except in Group I and Group III. Conclusion: Our study was able to differentiate dysplastic and malignant cells from normal ones using analysis based on nuclear and cellular parameters. We therefore conclude that cytomorphometric analysis using exfoliative brush cytology can be of great value for monitoring and follow up of suspicious lesions and can provide an excellent additional diagnostic test for detecting early oral malignancy.

      PubDate: Sun, 17 Feb 2013 08:08:14 GMT
       
  • Salivary Duct Carcinoma of the Minor Salivary Gland: A Rare Case Report

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Shalini Gupta, Khushboo Gupta, Hari Ram, Om Prakash Gupta.
      Salivary duct carcinoma is a rare invasive malignancy arising in the ductal epithelium of the salivary glands. Nearly 85% of the cases occur in the parotid gland followed by submandibular gland. Rarely is it described in the hard palate. Salivary duct carcinomas affecting the minor salivary glands have been reported in only 4% of the SDC cases and constitute 2% of all the salivary gland malignant neoplasms. It is characterized by aggressive behavior with early metastasis, local recurrence and significant mortality. The tumor has predilection for older men in the 6th to 7th decades of life. In this article; we report a case of a salivary gland carcinoma which was present in the right posterior region of the maxilla of a 50 year old female patient.

      PubDate: Tue, 05 Feb 2013 08:31:40 GMT
       
  • Fibrous Pseudotumour of the Testis

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Geetha Vasudevan, Bhavna Nayal, Lakshmi Rao.
      Fibrous pseudotumour of the testis is a rare benign lesion involving the paratesticular region. It usually presents in nodular form and may cause diagnostic dilemma resulting in unnecessary sacrifice of the testes. We report a rare case of diffuse fibrous pseudotumour which had to be treated by orchiectomy.

      PubDate: Mon, 04 Feb 2013 05:47:50 GMT
       
  • Role of HPV Vaccine in the Prevention of Cervical Cancer

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Saleh JA, Yusuph H, Zailani ZB.
      Background: Cervical cancer which affects relatively young women of child bearing age is considered to be the second most common cancer in women and a leading cause of cancer-related deaths in developing countries, a reflection of global health inequity. There are more than 450,000 newly diagnosed cases annually with over a quarter of million deaths recorded out of which over 80 percent are from the developing countries especially Africa, South Asia, South and Central America, and the Caribbean, with an exponential rise expected from this figure by 2020. The preventive measures available (Pap smear and HPV vaccine) aimed at reducing morbidity and mortality associated with this disease, has been shown to be very effective but difficult to implement especially in the developing countries partly due to lack of resources and mainly lack of government commitment amongst other things. This forms the basis of this review to look at the position of HPV vaccine in the prevention of cancer of the cervix. Method: In the course of this write-up, relevant literatures were reviewed using manual library search, relevant websites and internet articles. The key words employed were: cervical cancer, human papilloma virus, pap smear and vaccination. Results: It has been shown that, where resources permits, combining HPV vaccine in combination with pap smear screening methods especially to high risk group would greatly reduce the morbidity and mortality associated with cancer of the cervix. Conclusion: Although there are so many essential questions still unanswered, considering the havoc caused by this preventable gynaecological malignancy and coupled with the ever increasing costs of its treatment, the advantages of using HPV vaccine in addition to routine Pap smear as a means of preventing cancer of the cervix greatly outweighs the disadvantages. However, there is the need for caution to be adhered to when it comes to large scale vaccination programs in view of the fact that sufficient evidence is still lacking on the safety of the vaccines in the long-term.

      PubDate: Mon, 28 Jan 2013 17:07:05 GMT
       
 
 
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