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Journal Cover   Journal of Interdisciplinary Histopathology
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 2146-8362
   Published by ScopeMed Homepage  [96 journals]
  • Schistosomiasis: A Rare Cause of Acute Appendicitis

    • Abstract: 2015-05-22T14-21-16Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Saadia Bouraoui, Maroua Bouhamed, Ghada Sahraoui, Ahlem Lahmar, Sabeh Mzabi.
      Schistosomiasis is a water-borne trematode infestation and is one of the most widespread parasitic diseases in the world. Schistosomiasis can affect any organ, but is rare in the appendix. In this paper, the authors report a new case of appendicular schistosomiasis that was incidentally discovered in a 27-year-old male patient from Mali who underwent appendectomy for acute appendicitis. Appendectomy specimens removed from patients with appendicular schistosomiasis often appear macroscopically normal, but histopathological analysis of these cases confirms the diagnosis by revealing schistosomal eggs. The authors strongly recommend that all appendectomy specimens be examined histopathologically regardless of whether the specimens are macroscopically normal.

      PubDate: Tue, 19 May 2015 23:33:18 GMT
  • Bilateral Adenomyoepithelioma of the Breast Presenting With Breast Abscess
           in a Lactating Woman: A Case Report

    • Abstract: 2015-04-28T23-26-27Z
      Source: Journal of Interdisciplinary Histopathology
      Manna Valiathan, Padmapriya Jaiprakash, Geetha Vasudevan.
      The term adenomyoepithelioma has been applied to a broad range of biphasic lesions composed of epithelial and myoepithelial cells. They show diverse morphologic patterns due to the admixture of the two components which may lead to a diagnosis of malignancy. We present a case of bilateral adenomyoepithelioma in a lactating woman who had a concomitant breast abscess. A 25-year-old lady presented with bilateral breast lumps since 2 years, with acute pain. With a clinical diagnosis of an abscess, superimposed on fibrocystic disease, drainage of abscess, and lumpectomy was performed. The clinicopathological features of this entity are discussed.

      PubDate: Mon, 27 Apr 2015 06:45:22 GMT
  • A preventable complication of a slow growing cancer – Lessons learned
           and a literature review

    • Abstract: 2015-04-28T23-26-27Z
      Source: Journal of Interdisciplinary Histopathology
      Alethea Tan, Parneet Gill, Haitham Kashaba, Sally Hales, Fahmy Fahmy.
      Malignant tumors of the hand are rare. Chondrosarcoma presenting in the hand are usually low grade with low risk of metastasis. To our knowledge and following literature review, there are nine reported cases of metastatic chondrosarcoma of the hand worldwide in the English literature, with only two reported cases of axillary lymphadenopathy. We describe a case of an unusual presentation of chondrosarcoma of the left little finger with distant axillary and pulmonary metastases. We also review management issues unique to this patient and reflective learning points to improve care. Our patient could have had a satisfactory outcome if treated early. We recommend referral of suspicious hand lesions to a specialist hand surgeon, for early assessment and management, in order to reduce patient morbidity and mortality.

      PubDate: Sat, 25 Apr 2015 00:41:48 GMT
  • Effects of Menopause and Diabetes on the Rat Thyroid Gland: A
           Histopathological and Stereological Examining

    • Abstract: 2015-04-18T23-31-59Z
      Source: Journal of Interdisciplinary Histopathology
      Zeliha Yetim, Deniz Unal, Selina Aksak Karamese, Tolga Mercantepe, Jale Selli, Elif Polat, Basak Buyuk.
      Objective: Menopause is described as the arrest of the menstruation cycle and ending of reproductive potential. Diabetes mellitus (DM) occurs with Type 1 diabetes that is originated from the absence of insulin and Type 2 diabetes depending on insulin resistance. It is one of the most common endocrine disorders encountered in clinical practice that can cause serious health complications. Therefore, the objective of the present thesis was to investigate the effects of menopause and diabetes upon the thyroid using a rat model. Materials and Methods: 24, 12 weeks old female Sprague-Dawley rats were divided randomly into; non-diabetic healthy control group (Group I, n = 6), diabetic group (Group II, n = 6), ovariectomy group (Group III, n = 6), and ovariectomy plus diabetic group (Group IV, n = 6), respectively. Results: In histopathological examinations, the thyroid gland of the diabetic group had large follicles with cuboidal or almost squamous epithelial lining surrounding wide lumen. There were areas of disorganized follicles with decreased colloid. In the ovariectomized (OVX) rats, there was hyperplasia of the thyroid follicles and disorganized follicles with complete obstruction of their lumina. Mitotic cells were available. Some parafollicular cells had lack of cytoplasm. Post ovariectomy diabetes-induced group (Group IV), there were some species between follicles and remarkable reduction of colloid. Hyperplasia of the thyroid follicles, solid cell nests, and mitotic cells were also seen increasingly in this group. Follicular lumen area of ovariectomy group is closer to the control group. The increase of the lumen area in the DM group was the largest, diabetes+ovariectomy group also had an increase in the follicular lumen area. Conclusion: Finally; postmenopausal aging and diabetes in rats, may cause thyroid degeneration. DM and menopause both cause oxidative stress. But their damages on thyroid tissue are different. It means they cause oxidative stress via different ways. DM + OVX group compared to other groups has the greatest damage.

      PubDate: Wed, 15 Apr 2015 05:26:38 GMT
  • Intraosseous Schwannoma

    • Abstract: 2015-04-14T04-32-24Z
      Source: Journal of Interdisciplinary Histopathology
      Bhavna Nayal, Ranjini Kudva, Sandeep Kumar, Rajesh Parameshwaran Nair, Ashitha Nanaiah.
      Intraosseous schwannomas are rare and benign neoplasms originating from the nerve sheath cells. We present two such cases, one located in the ninth thoracic vertebrae and the other involving the sacrum. Clinicoradiological diagnosis in both the cases was a primary bone tumour. Histopathological examination revealed characteristic morphology of schwannoma which was confirmed by immunohistochemistry. These two cases highlight the importance of clinical, radiological and histopathological correlation in the diagnosis of these uncommon bone tumors.

      PubDate: Mon, 13 Apr 2015 12:47:20 GMT
  • Collagenous Gastritis: A Rare Entity

    • Abstract: 2015-03-18T20-13-22Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Sabeh Mzabi.
      Collagenous gastritis is a rare entity of unknown etiology characterized histologically by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of gastric mucosa. A 40-year-old male presented with a history of chronic intermittent abdominal pain for about 6 months. Physical examination was unremarkable, and biological tests were within normal range. The patient underwent esophagogastroduodenoscopy and colonoscopy which showed a nodular mucosa of the stomach. Biopsies of the duodenum and colon were unremarkable. However, biopsies of the gastric fundus revealed a mild chronic gastritis characterized by lymphocytic and plasma cell infiltration of deep mucosa, without lymphoid follicle formation or active inflammation. No microorganisms were identified on routine hematoxylin and eosin or Giemsa-stained sections. Subepithelial collagen in the gastric biopsies was thickened and showed entrapped capillaries. Subepithelial collagen was highlighted by Masson’s trichrome staining and was negative for amyloid by Congo Red. In the areas containing thickened collagen, there were no intraepithelial lymphocytes. The final pathological diagnosis was collagenous gastritis. Collagenous gastritis is an extremely rare disease, but it is important to recognize its characteristic endoscopic and pathologic findings to make a correct diagnosis. Specific therapy for this rare entity has not yet been established.

      PubDate: Wed, 18 Mar 2015 12:03:16 GMT
  • Gene Therapy and Stem Cells in the Treatment of Congenital Diseases.

    • Abstract: 2015-03-10T05-00-54Z
      Source: Journal of Interdisciplinary Histopathology
      Paula Rubya Souza Câmara.
      Several congenital diseases are particularly attractive candidates for intervention using gene therapy since the underlying molecular bases for most of the monogenic disorders are well-understood. Transplantation of ex vivo genetically modified stem cells has also shown promise. Although all of these systems are meritorious and worthy of continued investigation, this mini-review article focused on the platforms that have received the most attention and that are maturing in the clinical setting; in particular, the potential of in vivo gene therapy and human-induced pluripotent stem cells. Studies of apparently disparate diseases that are presumably linked through shared metabolic pathways are likely to provide greater insights into the biology of the diseases. This and other opportunities for exchange will hopefully foster acceleration in the development of new and innovative therapies for these devastating diseases.

      PubDate: Sat, 07 Mar 2015 10:01:41 GMT
  • Synchronous Superficial Myofibroblastoma and Stromal polyp of the Vagina:
           Report of A Case Supporting Common Histogenesis of Both Lesions

    • Abstract: 2015-03-05T04-32-38Z
      Source: Journal of Interdisciplinary Histopathology
      Michal Zamecnik, Roman Sucansky.
      Rare simultaneous occurrence of vaginal superficial cervicovaginal myofibroblastoma and vaginal stromal polyp is described. The lesions were found in a 90-years-old patient, in the anterior wall of the vagina. The diameter of the lesions was 6cm and 2cm, respectively. Between them, a 3cm part of normal appearing vaginal wall was present. Both lesions showed similar myoid appearing morphology and myofibroblastic desmin+/actin-/h-caldesmon-/CD34- immunophenotype, with positivity for CD10, CD99, estrogen receptor and progesterone receptor. Larger lesion was diagnosed as benign cervicovaginal myofibroblastoma, and the smaller one had typical features of vaginal stromal polyp. This case of simultaneous occurrence of cervicovaginal myofibroblastoma and vaginal stromal polyp supports previously suggested histogenetic relationship between these lesions.

      PubDate: Wed, 04 Mar 2015 05:26:39 GMT
  • Overview of the Last Two Years

    • Abstract: 2015-03-05T04-32-38Z
      Source: Journal of Interdisciplinary Histopathology
      Ayhan Ozcan.

      PubDate: Wed, 04 Mar 2015 04:13:36 GMT
  • Protective Effect of Rosemary (Rosmarinus Officinalis) Extract on
           Naphthalene Induced Nephrotoxicity in Adult Male Albino Rat

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Neveen Mohamed El-sherif, Noha Mohy Issa.
      Background: Naphthalene (NA) is a common environmental contaminant and is abundant in tobacco smoke. Rosemary (Rosmarinus officinalis) is a herb commonly used as a spice and flavoring agents in food processing and is useful in the treatment of many diseases. Aim of the work: To study the nephrotoxicity of NA and to evaluate the possible protective role of rosemary extract in adult male albino rat. Materials and Methods: 25 animals were divided into three groups: Group I (Control group), Group II (NA treated group) received NA at a dose of 200 mg/kg/day dissolved in 5 ml/kg corn oil orally by gastric tube, Group III (protected group) received rosemary extract (10 ml/kg/day) followed after 60 min by NA at the same previous dose orally by gastric tube. The experiment lasted 30 days. The following parameters were studied: Biochemical assessment of renal function, histological, immunohistochemical, morphometric studies and statistical analysis of the results. Results: NA treatment resulted in a highly significant increase in the mean values of serum urea and creatinine. NA induced histological changes in the form of glomerular congestion. Some glomeruli demonstrated marked mesangial expansion and hence that Bowman’s spaces were almost completely obliterated. Shrinkage of renal glomeruli with widening of Bowman’s spaces could also be seen. Focal tubular dilatation with appearance of casts inside the tubules was observed. Congested peritubular blood vessels and interstitial hemorrhage were also seen. The medullary region demonstrated vascular congestion and fibrosis. Focal cellular infiltration was presented in the interstitium. The renal cortex of NA treated rats showed a noticeable down regulation in alkaline phosphatase positive immunoreactive cells in some proximal convoluted tubules. NA induced up regulation of positive immunoreaction for inducible nitric oxide synthase in the proximal and distal convoluted tubules as well as in the collecting tubules. All previous results were significantly reversed in the protected group compared with NA treated group. Conclusions: It is concluded that NA has a harmful effect on rat kidney. Rosemary extract had a protective role against renal injury induced by NA and this effect may be attributed to its antioxidant and anti-inflammatory activity.

      PubDate: Fri, 20 Feb 2015 11:52:51 GMT
  • Appendiceal Hyperplastic Polyp: Case Report

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Faten Limaiem, Saadia Bouraoui, Maroua Bouahmed, Ghada Sahraoui, Ahlem Lahmar, Sabeh Mzabi-Regaya.
      Serrated lesions morphologically analogous to those seen in the colorectum are found in the appendix. Appendiceal hyperplastic polyps are very rare, and their true incidence is unknown. A 52-year-old male previously healthy patient with no particular past medical history, presented with a 24-h history of abdominal pain localized to the right lower quadrant. On physical examination, he was tender to palpation in the lower right quadrant. As acute appendicitis was highly suspected, laparoscopic appendectomy was performed. Histological examination of the surgical specimen showed acute inflammation of the appendiceal wall. The crypts were focally elongated but relatively straight with serrations that were visible mainly near the luminal end of the crypts. Columnar cells with or without apical mucous vacuoles alternated with large goblet cells. The crypt bases were not serrated and were lined by regular cells with small nuclei. The muscularis mucosa was intact. The postoperative course was uneventful, and the patient was discharged on postoperative day 1. The final pathological diagnosis was acute appendicitis associated with hyperplastic polyp. Hyperplastic lesions of the appendix are often incidental findings although they can be associated with acute appendicitis. They are significantly associated with adenocarcinoma elsewhere in the large intestine and the finding of mucosal hyperplasia in an appendectomy is an indication for further investigations to exclude colorectal neoplasia.

      PubDate: Tue, 17 Feb 2015 00:00:15 GMT
  • Granular Cell Tumor of the Breast: An Unusual Tumor of the Breast
           Masquerading As Malignancy

    • Abstract: 2015-02-23T09-31-24Z
      Source: Journal of Interdisciplinary Histopathology
      Padmapriya Jaiprakash, Kanthilatha Pai.
      Granular cell tumor (GCT) is a rare neoplasm of the breast, accounting for

      PubDate: Mon, 16 Feb 2015 23:24:50 GMT
  • Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat

    • Abstract: 2015-02-05T04-32-32Z
      Source: Journal of Interdisciplinary Histopathology
      Neveen M. El-Sherif, Abeer E. El-Mehi.
      Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compared with other consumers. Objectives: This study was performed to throw light on the effect of SEM on the testis of juvenile male albino rat. Materials and Methods: This study was carried out on 20 juvenile male albino rats divided into the control group, and SEM treated group. Animals of the SEM treated group were administered 40 mg of SEM orally once daily for 30 days. At the end of the experiment, animals were weighed and then sacrificed. The parameters examined were gonadal index, epididymal spermatozoal examination, histological study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in addition to ultrastructural study. Morphometric study and statistical analysis of the results were carried out. Results: The gonadal index of SEM treated group showed a significant decrease compared with the control group. Loss of germ cells was confirmed by a significantly low sperm count. SEM induced variable degrees of tubular affection in the form of distorted seminiferous tubules, cellular disorganization, sloughing and cytoplasmic vacuolation. Acidophilic hyaline material, vacuolations, and congested blood vessels were present in most of the interstitial spaces. Immunohistochemically, SEM treatment induced a marked reduction in the number of PCNA immunoreactive cells. An ultrastructural alteration of spermatogenic cells and wide separation in between germ cells were observed. Conclusions: These results suggest that growing animals are more susceptible to gonadal toxicity of SEM. It is better to avoid food products sold in glass jars, especially during the juvenile period.

      PubDate: Mon, 02 Feb 2015 13:25:19 GMT
  • Spectrum of Intestinal Neoplasms: A study of 400 cases

    • Abstract: 2015-01-11T13-13-38Z
      Source: Journal of Interdisciplinary Histopathology
      Aminder Singh, Bhavna Garg, Neena Sood, Harpreet Kaur Puri, Vikram Narang, Sumit Grover.
      Objective: The present study is a five-year analysis of all the tumors of small and large intestine received in the Pathology Department of Dayanand Medical College and Hospital, Ludhiana. Methods: All the cases were grossly and microscopically examined and were staged according to Astler Coller Staging and classified and subtyped according to WHO classification. The important differences between the small and large intestine tumors were also analyzed. Results: There were 400 cases out of which 356 were in large intestine while 44 were in the small intestine. There were only 56 benign neoplasms while 344 were malignant tumors. Adenomas were the most common benign tumors while majority of malignant tumors were adenocarcinomas. Lymphomas, mesenchymal tumors, and carcinoid tumors were much more common in a small intestine as compared to large intestine. Majority of adenocarcinomas were located in the large intestine with most of them being moderately differentiated having Astler Coller Stage B II. Mucinous carcinomas had the worst prognosis as compared to adenocarcinomas. Anal canal had mainly squamous cell carcinomas. Conclusions: Tumors of large intestine were much commoner than of small intestine. There was a higher incidence of tumor in males with M:F ratio of 2.2:1. Mean age of presentation of benign tumor was younger, i.e., 32.6 years when compared to 54.5 years for malignant tumors. Tubular adenoma was the most common benign tumor and adenocarcinoma the commonest malignant neoplasm.

      PubDate: Sat, 10 Jan 2015 10:59:57 GMT
  • Primary (Poorly Differentiated) Sclerosing Liposarcoma of Temporal Region.
           An Uncommon Tumor in a Rare Site: A Case Report

    • Abstract: 2015-01-02T04-20-43Z
      Source: Journal of Interdisciplinary Histopathology
      Anuradha CK Rao, Vidya Monappa, Sandeep Kumar.
      Liposarcoma (LS) in the head and neck region is a rare tumor. The sclerosing variant of LS is a subtype of well-differentiated LS characterized by areas of conventional LS admixed with hypocellular areas of stromal sclerosis that show atypical lipomatous cells. The (poorly differentiated) sclerosing LS, on the other hand, is more cellular with atypical, pleomorphic and often bizarre giant tumor cells admixed with atypical lipoblasts. We report a case of poorly differentiated sclerosing LS of temporal region in a 49-year-old man. Radiologically, the tumor was dumbbell shaped with intra and extra cranial extension. In this case, we discuss the clinico-radiological and pathological findings of an unusual tumor in a rare location.

      PubDate: Mon, 29 Dec 2014 06:23:36 GMT
  • Using Flow Cytometry for the Diagnosis of Lung Neuroendocrine Carcinoma
           With Samples From Endobronchial Ultrasound Fine Needle Aspiration and
           Pleural Fluid

    • Abstract: 2014-12-18T14-16-04Z
      Source: Journal of Interdisciplinary Histopathology
      Mark E Costaldi, Adam Lall, Richard Burack, Zhongren D Zhou.
      Objective: Diagnosis of primary and metastatic lung neuroendocrine carcinoma (LNC) is challenging with fine-needle aspiration (FNA) since the morphologic features of LNC and lymphoid lesions overlap. Flow cytometry (FC) is commonly utilized for lymphoid lesions; however, FC with cluster differentiation (CD) 56 and cytokeratin antibodies can also be used for the diagnosis of neuroendocrine neoplasia. Our studies compared the role of FC to immunohistochemistry (IHC) for the diagnosis of LNC from cytological specimens. Materials and Methods: Cases of LNC with both cytology and FC were identified in our pathology databases from 2008 until June 2012. IHC and FC results were compared in these cases. Results: Fifteen of 17 cases had immunohistochemical studies from cell block including cytokeratin (11/11, 100%), thyroid transcription factor-1 (6/8, 75%), synaptophysin (12/14, 86%), chromogranin (4/13, 31%) and CD 56 (10/11, 91%). Of all 17 cases, 13 cases had FC performed with antibodies for CD 56, cytokeratin (Cam5.2) and CD 45. Twelve of the 13 cases were positive for CD 56 (12/13, 92%), which was similar to the IHC results (10/11, 91%). Eleven cases were positive for cytokeratin by IHC and 10 were positive (10/12, 83%) for cytokeratin by FC. One case in our study which was CD 56+/Cam5.2+/CD 45− was diagnosed as carcinoid tumor by final morphology. Conclusions: Our results suggest that FC utilizing antibodies for CD 56/cytokeratin/CD 45 is a reliable alternative method for detecting LNC from FNA specimens when IHC fails or becomes unavailable. However, the morphology is still necessary for the diagnosis since the FC panel is not wholly specific for the subtypes of LNC.

      PubDate: Mon, 15 Dec 2014 13:50:37 GMT
  • Spondylodiscitis with Bronchopneumonia in Infancy- A Rare Entity

    • Abstract: 2014-12-10T13-09-52Z
      Source: Journal of Interdisciplinary Histopathology
      Shweta Pai, Shashikala Krishnamurthy, Kavita Umapathy, Kishan Bhagwat, Manjunath Lakmapurnath.
      Childhood spondylodiscitis is an extremely rare entity and accounts for 2-4% in neonates. Respiratory and other site infections are identified as sources of hematogenous spread. A 5-week-old male child was brought to the emergency department with respiratory distress and convulsions. On the evaluation, he had bilateral bronchopneumonia with septicemia and kyphosis. Computed tomography scan demonstrated spondylodiscitis with destruction of T5 -T6 vertebraewith abscess of right lower lobe of the lung. Subsequently, thoracotomy was done, and a biopsy sent from apical and posterior segments of the lower lobe of the right lung revealed bronchopneumonia, abscess with entrapped dead bony spicules and collapse. Early diagnosis and treatment of respiratory infections are critical as delay may result in vertebral destruction as seen in this case and could lead to potentially life-threatening complications.

      PubDate: Sun, 07 Dec 2014 11:52:21 GMT
  • Cytodiagnosis of Primary Actinomycotic Mycetoma of The Foot – A Case

    • Abstract: 2014-12-06T14-17-53Z
      Source: Journal of Interdisciplinary Histopathology
      Sneha S Desale, Dhiraj B Nikumbh, S N Kanthikar, Akshay Surana.
      Mycetoma is chronic suppurative granulomatous disorder of subcutaneous tissue characterized by localized swelling with multiple discharging sinus tracts of granules that are micro colonies of the causative agent. Madura foot/mycetomas are the infection caused by true fungi (eumycetoma) in 40% or filamentous bacteria (actinomycetoma) in 60% of the cases. Painless subcutaneous mass, multiple sinuses and purulent or seropurulent discharge that may contain grains is characteristic of mycetoma. Mycetomas are usually diagnosed on histopathology. There are very limited data on role of fine-needle aspiration cytology (FNAC) in diagnosing these lesions. The distinction between eumycetoma and actinomycetoma in FNAC is as accurate as histopathology. Herein, we report a case of primary actinomycotic mycetoma of right foot in 65-year-old male patient. FNAC of soft tissue mass was advised, which revealed mixed inflammatory infiltrate with clumps of fibrillar organisms and occasional foreign body giant cells. Cytodiagnosis of actinomycetoma was rendered and Gram-stain was done later demonstrated Gram-positive thin branching filaments. Mycetoma can be accurately diagnosed by FNAC in outpatient department, which is simple, inexpensive, routine procedure for rapid diagnosis, and differentiation of etiology as the treatment differs.

      PubDate: Fri, 05 Dec 2014 12:03:57 GMT
  • Birth Defects in Newborns: Spina Bifida Index at Rio Grande Do Norte State
           in Brazil

    • Abstract: 2014-11-17T23-28-47Z
      Source: Journal of Interdisciplinary Histopathology
      Arnaldo CM Junior, Paula Rubya Souza Câmara.
      Objective: Among birth defects (BD) or congenital anomalies, spina bifida (SB) is the most common congenital malformation of the central nervous system that is associated with significant lifelong morbidity. We aimed to obtain statistics index of SB in newborns at Rio Grande do Norte (RN) state, Brazil, as well as to identify perinatal risk and to update therapeutic options to minimize the mortality in newborn with SB congenital defects. Materials and Methods: Retrospective study of SB index in newborn in Pediatric Hospitals at RN State, Brazil, over the 6 years from 2008 to 2013 and literature review about SB global status was made at PubMed database, reference lists of selected publications and important research groups in the field of SB. Conclusion: Northeast region is the one that has the major incidence of SB in Brazil country, but RN state has a number lower than others states from its region. It was made an update about therapeutic options to minimize the morbidity and mortality in newborn with SB congenital defects.

      PubDate: Mon, 17 Nov 2014 14:40:51 GMT
  • A Logistic Regression Model Predicting Malignancy in Follicular Thyroid
           Lesions Based on CD56 Expression and Patient’s Age

    • Abstract: 2014-11-17T23-28-47Z
      Source: Journal of Interdisciplinary Histopathology
      Eman Abdelzaher, Azza Mohamed Rizk, Maram Allam.
      Objectives: Follicular thyroid lesions represent a heterogeneous group with variable biological behavior. Discrimination between benign and malignant follicular thyroid lesions by histologic examination poses a significant challenge to pathologists. Recently, CD56 has attracted attention as a potential diagnostic marker in follicular thyroid lesions. Materials and Methods: A retrospective immunohistochemical and statistical analysis of CD56 expression in 68 cases of follicular thyroid lesions were done. Results: CD56 expression was significantly higher in papillary thyroid carcinoma (PTC) (conventional and follicular variants) compared to other categories of follicular thyroid lesions. And it was significantly higher in the follicular variant of papillary carcinoma compared to follicular adenomas (FA) and hyperplastic nodules (HN). A bivariate analysis showed that the malignancy in follicular thyroid lesions was significantly associated with higher CD56 expression and older patients’ age. Both parameters were used to build a logistic regression model and equation for prediction of malignancy in follicular thyroid lesions. On the application of the equation to the studied cases, it was found to conform to their diagnostic nature. Conclusions: We conclude that CD56 could serve as a good positive marker favoring the diagnosis of PTC (conventional and follicular variants) over other categories of follicular thyroid lesions. It also could be of value in differentiating follicular variant of papillary carcinoma from other lesions of a benign nature such as FA and HN. CD56 expression is significantly associated with malignant behavior in thyroid follicular lesions, which suggests a role for CD56 in tumor genesis. More importantly, the developed model and equation based on CD56 expression and patients’ age might be of value in the prediction of malignancy in follicular thyroid lesions, but it needs to be validated on a large scale accompanied by follow-up.

      PubDate: Mon, 17 Nov 2014 13:13:19 GMT
  • Subcellular Expression of Mammary Serine Proteinase Inhibitor (MASPIN) in
           Locally Advance Oral Squamous Cell Carcinoma

    • Abstract: 2014-11-17T23-28-47Z
      Source: Journal of Interdisciplinary Histopathology
      Samina Zaheer, Abdul Hannan Nagi.
      Objectives: Mammary serine protease inhibitor (MASPIN) has numerous interactions with tumor pathogenesis and progression. Its relationships with apoptosis and angiogenesis have proven the impact on prognosis. However, its exact role is not known and needs further work in relation to various human cancers. Current study was planned to investigate the subcellular expression of MASPIN in oral squamous cell carcinoma (OSCC) and to observe its relation with tumor grade. Methods: It was a descriptive study, conducted at the Department of Morbid Anatomy and Histopathology, University of Health Sciences, Lahore. Histological diagnosis of squamous cell carcinoma was confirmed in 50 cases, and expression of MASPIN was determined by avidinbiotin-peroxidase complex method of immunohistochemical staining. MASPIN expression was scored on the basis of intensity of staining and the percentage of the cells that stained positively. Data was analyzed with SPSS using appropriate statistical procedures. Results: Mean age of the patients was 56.84 ± 1.58 years with male to female ratio 1.3:1. All tumors were locally advancing (Stage III). Histologically, 58% tumors were Grade 1, other grades were less common. MASPIN expression was observed in 32 (64%) cases, and it was localized to the cytoplasm of the tumor cells in all cases. Among the positive cases, its expression was focal in 15 (44.1%), diffuse but moderate in 13 (38.2%) and diffuse and intense in 6(17.7%) cases. MASPIN expression was significantly associated (P: 0.043) and negatively correlated (P: 0.034) with tumor grade. Conclusions: MASPIN expression was observed in the majority of OSCC. However, it was localized to the cytoplasm of tumor cells in all cases. Loss of MASPIN expression was observed more frequently in poorly differentiated cancers.

      PubDate: Mon, 17 Nov 2014 12:58:28 GMT
  • Hypomethylation of Long Interspersed Nuclear Element-1 is Involved in the
           Early Tumorigenesis of Hepatocellular Carcinoma

    • Abstract: 2014-11-17T23-28-47Z
      Source: Journal of Interdisciplinary Histopathology
      Wenhua Piao, Wei Wang, Henghui Zhang, Xudong Gao, Liyuan Jin, Jianhui Qu, Zhongxian Xu, Yongping Yang, Zhe Piao.
      Objective: Hypomethylation of long interspersed nucleotide elements 1 (LINE-1) promoter has been reported in many cancer types including pancreatic endocrine tumors, colon cancers, and stomach carcinomas. Hypomethylation of LINE-1 is also frequently observed in hepatocellular carcinoma (HCC). However, it still unknown how LINE-1 is involved in the hepatocarcinogenesis. Methods: The level of LINE-1 promoter methylation in 28 HCC was detected by a methylation specific polymerase chain reaction (MSP) at CpG site seven of LINE-1 promoter region (gene bank: X58075). A fractional allelic loss (FAL) of these tumors was evaluated by a combination of loss of heterozygosity with microsatellite markers D4S1545, D4S2920, D8S264, D8S1752, D16S498, D16S514, and p53. The associations between the level of LINE-1 hypomethylation status and the clinico-pathological parameters were finally observed. The clinicopathological parameters were included hepatitis B virus (HBV) status, cirrhosis, tumor size, tumor differentiation and FAL. Results: High level of hypomethylation of LINE-1 promoter was found both in the advanced tumors (>3 cm), (7/18, 39%) and in the early tumors ( 0.535). There were 41% (7/17) tumors with a high level of hypomethylation in the low FAL group and 54.5% (6/11) tumors with a high level of hypomethylation in the high FAL group. No associations between the level of hypomethylation of LINE-1 and HBV infection, age, sex, and cirrhosis were found. Conclusions: These results are strongly suggested that the hypomethylation of LINE-1 plays a role in the hepatocarcinogenesis; moreover, the hypomethylation of LINE-1 occurs not only in the progression of HCC, but also in the early stage of HCC tumorigenesis.

      PubDate: Mon, 17 Nov 2014 12:42:13 GMT
  • Effect of Exposure to Non-ionizing Radiation (Electromagnetic Fields) on
           Human System: A Literature Review

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Paula Rubya Souza Câmara.
      The indiscriminate presence of radio base stations, which emit non-ionizing radiation (NIR), as well as the frequent use of mobile phones, can cause increased susceptibility of populations to the emergence of diseases such as cancers of the head and neck, biochemical, hematopoietic and hepatic changes, among others. Exposure to physical contamination, including NIR, has been implicated in numerous diseases, raising concerns about the widespread sources of exposure to this type of radiation. This paper reviews studies that have assessed associations between likely exposure to electromagnetic fields, such as radiofrequency transmissions, and many kinds of human diseases including cancer, as well as alerts to the current knowledge on the association between environmental exposure to NIR and the risk of development of adverse human health effects. This way, there appears to be an urgent need to reconsider exposure limits for low frequency and static magnetic fields, based on combined experimental and epidemiological research.

      PubDate: Tue, 23 Sep 2014 13:30:52 GMT
  • An Insight into Corneal Button Histopathology in Dystrophies Following
           Keratoplasty: A Prospective Study

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Nandeesh BN, Usha Kini, Rekha Gyanchand, Anil Felix Fonseca.
      Background: The prognosis and outcome of a tissue transplant is dependent on its pathology and though, penetrating keratoplasty (PKP) is the most successful tissue transplant, most of its studies are genetic/clinical based. This histopathology study on corneal dystrophies is aimed at correlating clinicopathology with graft outcome in an attempt to understand the pathology better. Material and Methods: Corneal buttons from all age groups where PKP was performed for dystrophy / degeneration were prospectively selected over three and half years by convenient sampling. Corneal buttons of keratoconus and bullous keratopathy (aphakic/ psuedophakic) following PKP were also studied, though they are neither specific dystrophy/degeneration and showed non-specific stromal changes. Results: One hundred and ten corneal buttons (40.3%) with dystrophy (n=44) and degeneration (n=66) from 273 cases of PKPs were studied histopathologically. Ninety percent of dystrophies and 66% of degenerations showed a very good clinicopathologic correlation. Macular, Lattice and Avellino`s dystrophies among dystrophies and Salzmann’s nodular degeneration showed specific stromal deposits making them easily diagnosable at histopathology while the rest showed non-specific stromal changes mandating correlation with clinical findings. Seven regraft corneas showed stromal fibrosis making identification of primary dystrophy impossible. However, transmural vascularization and lymphocytic stromal infiltrate were prominently noted in failed grafts though their numbers were few. Conclusion: This histopathologic study characterizes classic features of macular, Avellino’s, lattice corneal dystrophies and Salzmann’s degeneration for their microscopic diagnosis while the rest showed non-specific changes. Stromal edema was prominently noted in degenerations than in dystrophies. Degree of stromal vascularization and type of cellular infiltrate need attention in regrafts.

      PubDate: Wed, 10 Sep 2014 04:36:26 GMT
  • Warfarin Related Nephropathy and Beyond. What Renal Pathologists Need To
           Suspect in A Kidney Biopsy.

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergey V Brodsky, Anjali A Satoskar, Tibor Nadasdy.
      We have recently described a new clinical syndrome in patients receiving warfarin for anticoagulation. First, we identified that warfarin therapy can result in acute kidney injury (AKI) by causing glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts in some patients. This syndrome has been named warfarin-related nephropathy (WRN), and patients with chronic kidney disease (CKD) appear to be particularly susceptible. We defined WRN as an acute increase in INR to greater than 3.0, followed by evidence of AKI (defined as a sustained increase in serum creatinine of greater than or equal to 0.3 mg/dl) within a week of the INR increase. We believe that anticoagulant-related kidney injury should be suspected in a patient on an anticoagulation therapy, if there is a disproportion between the number of RBC tubular casts, ATN and the degree of an underlying kidney lesion (such as glomerular immune complex depositions, GBM thickness abnormalities etc) in kidney biopsy. Detailed evaluation of coagulation data and medications is recommended for all patients with RBC casts and AKI.

      PubDate: Thu, 07 Aug 2014 23:33:05 GMT
  • Arterial and Arteriolar Lesions in Renal Allografts: A Differential
           Diagnostic Approach

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Anjali A Satoskar, Sergey V Brodsky, Gyongyi M Nadasdy, Tibor Nadasdy.
      Renal allograft pathology is quite a complex issue and has been addressed in many monographs and book chapters. Renal allografts can fail secondary to rejection, but recurrent renal diseases and de novo diseases affecting the allograft may also contribute to the demise of the transplanted kidney. As a pathologist, one needs to examine the four compartments of the kidney (glomeruli, tubules, interstitium, and vasculature) separately and integrate the histology with the clinical presentation. Although glomerular and tubulointerstitial changes can be quite relevant in terms of renal allograft outcome and prognosis, correct evaluation of arterial/arteriolar changes in a renal allograft is crucial in making the appropriate diagnosis and the arterial/arteriolar changes may provide relevant prognostic information. The pathologist should very carefully study and describe the vascular changes in a renal allograft and correlate them with clinical findings. If arteries are not present, or if only a single or two small terminal interlobular arteries are seen, the biopsy report should indicate this and draw attention to possible sampling errors and to limited informative value of the specimen. In this review, we will try to provide a short review on vascular changes in renal allografts with a differential diagnostic approach.

      PubDate: Wed, 09 Jul 2014 09:21:26 GMT
  • Low Grade Fibromyxoid Sarcoma of the Mesentery, an Under Recognised
           Entity: A Case Report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Geetha Vasudevan, Archana Shivamurthy.
      Low grade fibromyxoid sarcoma (LGFMS) is an indolent, rare soft tissue tumor having potential of late metastasis, but high local recurrence rate despite its low grade histologic findings. The morphologic diagnosis may be challenging, owing to its typically low cellularity, abundant collagen, and relatively bland cytology. We present here a rare case report of a mesenteric mass in an elderly male. The mass was excised. On microscopy, the tumor was composed of sweeping fascicles of spindle cells, which were positive for vimentin and negative for CD117, CD34, smooth muscle antigen and S-100. Herein we report a rare, under recognized case of LGFMS arising in the mesentery.

      PubDate: Wed, 25 Jun 2014 04:49:48 GMT
  • Managing Epiglottal Chondrosarcoma of a Dog: A case report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ahmed M Shoieb.
      A primary chondrosarcoma was found in the epiglottis of a 6-year-old, neutered, male Boxer cross-breed dog. Clinically, there was upper respiratory noise, and a 3.2 cm × 2.8 cm × 2.7 cm, ovoid mass involving the epiglottis was observed. No abnormalities were detected upon radiographic examinations (X-ray) of the chest or abdomen. Grossly, the excised mass was hard. On cut section, it displayed a lobular pattern of translucent gray-white color (interpreted as cartilage). Histologically, the epiglottal submucosa contained a non-encapsulated, fairly demarcated multi-nodular neoplasm composed of streams of cells admixed with moderate to abundant amounts of a pale amphophilic to eosinophilic matrix (chondroid). The neoplastic cells stained were immunohistochemically positive for vimentin and S-100 protein, and negative for pancytokeratin. The matrix stained deeply with Alcian Blue (pH 2.5)-periodic acid Schiff, which often separated cells into individual lacunae. To the best of our knowledge, this is the first report of extra-skeletal chondrosarcoma primarily arising in the epiglottis of a dog.

      PubDate: Wed, 25 Jun 2014 04:34:54 GMT
  • Isolated Juvenile Xanthogranuloma in Thoracic Spine: Intraoperative
           Cytological Diagnosis of a Rare Presentation

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Shashi Singhvi, Shruti Bhargava.
      Juvenile Xanthogranulomas (JXG) are benign proliferative disorders of non-Langerhans histiocytes, which present in children as multiple, self-limited, cutaneous lesions. The extracutaneous manifestations of JXG are uncommon, and isolated JXG involving the spinal column is extremely rare. We report here a case of isolated juvenile xanthogranuloma in thoracic spine correctly diagnosed intraoperatively on crush smear cytology and later confirmed by histopathological and immunohistochemical studies. This case report draws attention to the fact that isolated xanthogranuloma should be considered among possible diagnoses of spinal tumor in children. Also, since the long term survival depends on complete surgical resection, a correct intraoperative diagnosis is extremely important for optimal management and prognosis of the patient.

      PubDate: Mon, 16 Jun 2014 00:54:15 GMT
  • Giant Solid-Pseudopapillary Neoplasm of the Pancreas in a Child

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Nandeesh BN, Kanishka Das.
      Solid-pseudopapillary neoplasm of the pancreas (SPPNP) is a primary epithelial neoplasm of the exocrine pancreas with borderline malignant potential. The unusual features included the ‘giant’ size and the absence of metastases/ capsular or vascular invasion despite the large size and predominantly solid nature. At two years following complete excision, she is asymptomatic and the imaging shows no recurrence/metastases.

      PubDate: Sun, 08 Jun 2014 05:10:51 GMT
  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel
           Density (MVD)-Related Markers, and Clinicopathological Features in
           Colorectal Carcinoma

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou.
      Objectives: Intercellular adhesion mediated by claudin and cadherin/catenin complex is a prerequisite of epithelial integrity and differentiation and has been suggested to be frequently disturbed in cancers. Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in angiogenesis than pan-endothelial markers such as CD31. The aim of this study was to assess the relationship between these markers and clinicopathological features of colorectal carcinomas. Materials and Methods: Surgical specimens from 69 patients with colorectal cancer were immunostained for claudin-1, E-cadherin, β-catenin, endoglin and CD31. Results: Forty-six (66.7%), 67 (97.1%), and 67 (97.1%) of the tumors, expressed immunostaining for claudin-1, E-cadherin and β-catenin, respectively. A significant association was seen between claudin-1 and E-cadherin expression (p=0.002), as well with β-catenin (p=0.009). High β-catenin expression appeared to reduce the risk of poor outcome. Endoglin vessel expression was correlated significantly with vessel invasion (p

      PubDate: Tue, 27 May 2014 12:45:24 GMT
  • The Significance of Mast Cells and Eosinophils Counts in Surgically
           Resected Appendix

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ashwini Kolur, Ashok M Patil, Vaibhav Agarwal, Saeed Yendigiri, BB Sajjanar.
      Objectives: The mast cell remains an enigmatic cell, found resident in tissues throughout the body particularly in association with structures such as blood vessels and nerves. Various inflammatory disorders of the intestines, joints and lungs appear to be associated with an increase in mast cell numbers. The study was conducted on vermiform appendix. The present study was undertaken (1) to compare the mast cell and eosinophil counts in various layers of the appendix in various histopathological groups, and (2) to establish the relationship between the numbers of eosinophils and mast cells in the inflamed appendix. Materials and Methods: The material for study consisted of appendix specimens received for histopathological examination in the Department of pathology. A 5 year study was conducted, 3 years retrospective and 2 years prospective. Results: Out of 777 cases studied the incidence of appendicitis is high, in the first and second decades of life and slightly higher in females. Recurrent appendicitis was more common when compared to other inflamed appendices. Conclusions: Eosinophil counts in all the layers were very high in acute eosinophilic appendicitis compared to normal appendices. A higher mast cell count was seen in acute eosinophilic appendicitis and recurrent appendicitis. No correlation was found between mast cell and eosinophilic density. Our observations support the allergic theory of appendicitis rather than the obstructive theory.

      PubDate: Tue, 13 May 2014 22:34:06 GMT
  • Suprasellar Anaplastic Meningioma Masquerading As Craniopharyngioma: A
           Case Report

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Eman Abdelzaher, Ahmed Farhoud.
      Anaplastic meningiomas are uncommon. We report the clinical, radiological and pathological features of an anaplastic meningioma in a young male Egyptian patient presenting as a suprasellar solid/cystic enhancing mass resembling a craniopharyngioma.

      PubDate: Fri, 18 Apr 2014 06:00:50 GMT
  • Does Clinical Staging and Histological Grading Show Parallelism In Oral
           Submucous Fibrosis' A Retrospective Study from an Indian City

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Manish Narayan, Dominic Augustine, Tina Jacob, Kumar Chandan Shrivastava, Deepti Shrivastava, Shylaja Narayan.
      Objectives: Oral submucous fibrosis is a common oral health problem in India. This study was conducted to correlate the histopathological diagnosis with habits and clinical findings in patients suffering from oral submucous fibrosis (OSF). Methods: The study group comprised of randomly included 40 patients. A comparison between clinical staging (a method used to find out the stage of disease using tests which include physical examination) and histopathological grading (grading is a measure of the cell appearance in pathology) was done in each case. Fisher’s exact test was done to obtain statistical analysis. Results: Among 15 cases of clinically diagnosed stage I lesions, 4 (10%) were grade I, 6 (15%) were grade II and 5 (12.5%) were grade III. Among 23 cases of stage II lesions 6 (15%) were diagnosed as grade I, 7 (17.5%) as grade II, 7 (17.5%) as grade III and 3 (7.5%) as grade IV. Among 2 cases of stage III both were diagnosed as grade II respectively. Conclusions: There was no correlation between clinical staging and histopathological grading of oral submucous fibrosis. The test results were statistically not significant. (p=0.635) This may be due to difference in severity and extent of fibrosis in different parts of the oral mucosa.

      PubDate: Sat, 12 Apr 2014 10:06:53 GMT
  • Metastatic Esophageal Squamous Cell Carcinoma in the Kidney

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sunita Singh, Sonia Chhabra, Pansi Gupta, Shivani Malik, Megha Ralli, Padam Parmar.
      Metastases from esophageal cancers represent only 4.8 per cent of secondary renal tumors. The kidney is known to be the 4th or 5th most common visceral metastasis site of esophageal carcinomas. More than 50% of renal metastases typically show bilateral involvement. Solitary, unilateral renal metastasis is extremely rare. Therefore, the diagnosis of renal metastases is very difficult. We report a case of solitary unilateral renal metastases in an esophageal squamous cell carcinoma in a 66 year old man’s autopsy.

      PubDate: Sun, 16 Mar 2014 12:49:52 GMT
  • Intravascular Papillary Endothelial Hyperplasia (Masson’s
           Hemangioma) Presenting as Soft Tissue Mass in Left Scapular Region-An
           Unusual Presentation

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Meenu Gill, Ashima Batra, Deepika Jain, Veena Gupta, Rajeev Sen, Sumiti Gupta.
      Intravascular papillary endothelial hyperplasia (IPEH) or reactive vascular endothelial lesion is a rare benign condition and is also known as Masson’s hemangioma. It may appear as a primary or pure form developing in a distended vessel, or it can be associated with hemangiomas, pyogenic granulomas, or lymphagiomas. It is usually confined to the lumen of preexisting vessels or vascular malformations. Nearly all the lesions are intimately associated with a thrombus in various stages of organization. The main significance of IPEH is its clinical and histological resemblance to soft-tissue sarcoma and possible misinterpretation as such. We hereby report a case of IPEH clinically and radiologically misdiagnosed as soft tissue sarcoma, in a 47-year-old man, presenting as a soft tissue mass in the left scapular region.

      PubDate: Fri, 14 Mar 2014 06:21:17 GMT
  • Renal Biopsy for Research: An Overview of Russian Experience

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergei V. Jargin.
      Renal biopsy is a relatively safe procedure with a well-defined risk profile. A biopsy for research is one that is carried out without clinical indications purely for research purposes. Research biopsies often have a parallel clinical purpose, therefore requiring more tissue to be sampled. Research as a purpose of a renal biopsy presupposes informed consent. This review is discussing several publications from the past, but the problem is still with us: invasive procedures performed primarily for research sometimes of questionable reliability. In the author’s opinion, renal biopsy should always be performed according to clinical indications. If the patient gives consent to research on the renal tissue obtained for the diagnostic purposes, it can be done, provided that enough tissue remains for the diagnostics, and that Institutional Review Committee approves of the research project.

      PubDate: Thu, 13 Mar 2014 08:17:39 GMT
  • Survivin Expression in Renal Epithelial Tumors: It’s Usage in the
           Differential Diagnosis of Eosinophilic Renal Epithelial Tumors

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Ayhan Ozcan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, Sukru Ozaydin.
      Objective: The differential diagnosis of renal tumors can be problematic due to overlapping morphologic features. The purpose of this study was to assess the potential contribution of survivin expression in the differential diagnosis and determination of therapy modalities of these tumors. Methods: This study consisted of 15 chromophobe (ChRCC), 15 clear cell (CCRCC) and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas. Sections were stained against survivin antibody. Results: PRCCs and CCRCCs showed diffuse and strong survivin expression. Survivin expression was strikingly prominent in type1 PRCCs and cystic CCRCCs. In CCRCCs, survivin expression was more pronounced in low grade areas than high grade and sarcomatoid areas. In ChRCC, survivin expression was more limited and weaker than that of oncocytomas and other malignant renal tumors. In non-neoplastic renal tissue, survivin expression was more pronounced in podocytes and atrophic tubules than other nephron parts. Conclusions: Our results suggested that survivin may helpful in the differential diagnosis of renal tumors despite limited number of our cases. Experimental studies have revealed that inhibition of survivin induces apoptosis and enhance radiosensitivity of RCC cells. Taken together, to be known the proportion of survivin expression in subtypes of renal tumors may contribute to determine new therapeutic strategies for RCCs. This needs to be proven in more wide series.

      PubDate: Thu, 13 Mar 2014 04:44:02 GMT
  • Anabolic Androgen-induced Intrahepatic Cholestasis Presented With Normal

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Savvoula Savvidou, Asterios Gagalis, Ioannis Efstratiou, Athanasios Kalambakas.
      The indisputable hepatotoxicity of anabolic androgen steroids has already been well substantiated in the literature, eventhough the exact pathophysiologic mechanisms are still being elucidated. Androgen-induced liver injury presents primarily with acute intrahepatic cholestasis accompanied by markedly elevated cholestatic enzymes and diverse levels of aminotransferases. A case report of a young male with remarkable jaundice due to acute anabolic androgen-induced cholestasis is presented. Interestingly, γ-glutamyl transpeptidase remained normal throughout the patient’s diagnostic workup. Histopathology was indicative of pure, “bland” intrahepatic cholestasis with minimal inflammation but significant fibrosis. The patient was successfully treated with ursodeoxycholic acid and glucocorticosteroids. The significance of normal γ-glutamyl transpeptidase along with the histopathological findings and the possible pathophysiological mechanisms are finally discussed.

      PubDate: Mon, 10 Mar 2014 11:41:54 GMT
  • The Protective Effect of Curcumin versus Sodium Nitroprusside on
           Intestinal Ischemia/Reperfusion Injury

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Dalia M Saleh, Rania N Sherif.
      Objective: Intestinal ischemia/reperfusion (I/R) injury is a significant complication in abdominal vascular surgery. Various treatment modalities have been applied, however, the role of nitric oxide (NO) in this type of injury is still controversial. Aim of the work: To compare the protective effect of curcumin vs sodium nitroprusside (SNP, NO donor) on intestine and remote organs following intestinal I/R injury. Methods: Rats were divided into 4 groups (sham-control, I/R, curcumin+I/R, SNP+I/R). I/R was induced by 30 min clamping the superior mesenteric artery (SMA) then 60 min reperfusion. Rats were pretreated with either curcumin (80 mg/kg/day) with food for one week or SNP (5 mg/kg, i.p) prior to I/R. Intestinal levels of malondialdehyde (MDA), Nitrite/nitrate, superoxide dismutase (SOD) and reduced glutathione (GSH) were measured. The sections from jejunum, lungs and liver were stained with hematoxylin and eosin (H&E) for histopathological examination. Immunohistochemical stains for eNOS expression in the jejunum and cleaved caspase-3 for apoptosis in the lungs and liver were done. Results: I/R resulted in both local and remote organs inflammation associated with significant increase in MDA and nitrate/nitrite and significant decrease in SOD and GSH levels. These histological and biochemical changes were improved by pretreatment with curcumin and to less extent by SNP. Immunohistochemical examination showed significant decrease in eNOS activity in the I/R group which was improved by curcumin pretreatment not by SNP. Liver apoptosis was improved by curcumin while lung apoptosis was improved by SNP. Conclusion: Curcumin ameliorates I/R-induced local and remote organs damage through its anti-inflammatory and antiapoptotic effect. SNP may be beneficial in I/R injury but not as significant as curcumin.

      PubDate: Mon, 03 Mar 2014 02:12:54 GMT
  • Giant Congenital Cerebriform Melanocytic Nevus of the Scalp in Adult

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Shashikala Krishnamurthy, Kavita GU, Shamila Mohamed Ali, Nagaraj Parvatappa.
      Congenital melanocytic nevi are defined as benign nevomelanocytic proliferation present at birth. They are rare lesions and occur in approximately 1% of new-borns and are usually classified according to their size. We report a case of 32 year old female who presented with a giant cerebriform lesion of the scalp which was present since birth. Diagnosis of Giant congenital melanocytic nevi was made on the basis of definite histological criteria. Wide excision of the lesion was done with split skin graft. This case is unique due to the fact that this young female lived with this disfiguring lesion for 3 decades and never consulted any physician for cosmetic purpose and fortunately the lesion never turned malignant.

      PubDate: Thu, 27 Feb 2014 05:20:03 GMT
  • Cytologically Diagnosed Ovarian Carcinoma Turned Out To Be a Case of
           Chronic Ectopic Pregnancy

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Snehamay Chaudhuri, Saikat Datta, Prabir Chandra Paul, Sumana Mukherjee, Samaresh Malo.
      Background – The diagnosis of chronic ectopic pregnancy is often difficult as there is a shortage of literature in which this disease is diagnosed as an entity separate from the condition of acute ecopic pregnancy. Experience with fine needle aspiration cytology in chronic ectopic pregnancy is not reported previously. Case - A 29-year-old para 3 woman presented with lower abdominal pain and irregular menstruation since two months Transvaginal ultrasonography showed a well defined heterogenous, solid-cystic right adnexal mass with normal serum beta HCG , and mildly elevated CA 125 level . Fine needle aspiration cytology from the mass suggested possibility of serous cyst adenocarcinoma. Abdominal hysterectomy with bilateral salpingo-oophorectomy and infra-colic omentectomy was done. Pathological findings were consistent with chronic ectopic pregnancy. Conclusion –It is possible to retrieve trophoblastic cells through fine needle aspiration even after 2 months of tubal rupture and this experience can be utilized to diagnose chronic ectopic pregnancy preoperatively.

      PubDate: Tue, 25 Feb 2014 12:45:31 GMT
  • Congenital Pouch Colon: A Rare Variant of Anorectal Malformation:
           Histopathological Perspective with Brief Review of Literature

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Dhiraj B Nikumbh, Kishor Suryawanshi, Sudhir Singhavi, Poonam Pagare, Akshay Surana.
      Congenital pouch colon is an extremely rare variant of anorectal malformation (ARM) in which all or part of colon is replaced by a pouch like dilatation that communicates distally with the urogenital tract by a large fistula. Congenital pouch colon differs from normal colon structurally, histologically and functionally. The incidence of congenital pouch colon among all cases of anorectal malformation in northern India has been reported to be between 5-10%. Rest of the India and around the globe handful of documented case reports was noted. The mortality from congenital pouch colon has decreased from 40% to 15%, if identified and managed properly. Herein, we report a case of 10 days male child presented with congenital pouch colon in view of a rare congenital anomaly. We enlighten the detailed histopathological findings in this case as there is paucity of literature of congenital pouch colon.

      PubDate: Mon, 24 Feb 2014 22:09:50 GMT
  • Extraovarian Primary Peritoneal Carcinoma: A Clinicopathological Gray Zone

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Kajal Basavaraj Punyashetty, Anand Anantharao Shankar, Trupti Vyasrao Katti.
      Extraovarian primary peritoneal carcinoma (EOPPC) is a rare disease entity, arising from extra ovarian peritoneum with abdominal carcinomatosis, uninvolved or minimally involved ovaries and no identifiable primary. Since an overlap of clinical manifestations and histologic appearances of EOPPC and papillary serous ovarian carcinoma exists, various diagnostic modalities like cytology, tumor markers, gross and histomorphological features, collectively help in arriving at a definitive diagnosis. As very few cases have been reported in literature, we hereby document one such interesting case.

      PubDate: Mon, 17 Feb 2014 21:57:08 GMT
  • Histopathologic Effect of Prenatal Topiramate Exposure on Rat Cerebral
           Cortex and Hippocampus

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Hagar A Hashish.
      Objective: Topiramate is a recent antiepileptic agent approved for treatment of seizure in adults, children and during pregnancy. No much available reports concerning topiramate teratogenic potential in humans. This could be explained by limited number of pregnancies exposed. Very few reports are available on animal experimentation with controversial results. This work aimed to clarify the histopathologic effects of prenatal topiramate exposure on the cerebral cortex and the hippocampus of newborn rats. Material and methods: 12 female pregnant rats were divided into control and treated groups, 6 rats in each group. The treated group was given topiramate dissolved in tap water, from day 0 of pregnancy till the delivery, through oral route in dose of 200mg/kg. The control group received tap water at the same time. In the end of the treatment, the cerebral cortex and the hippocampus were stained with hematoxylin and eosin (H&E) and immnunohistochemically for glial fibrillary acidic protein (GFAP). Results: The control rat cerebral cortex showed that granule cells were small cell with dense cytoplasm, pyramidal cells appeared with triangular cell body, light cytoplasm and small nucleus. Strong GFAP positive immunostaining was detected in the astrocytes in both granule cell and pyramidal cell layers. The pyramidal cells in Cornu Ammonis showed characteristic palisade arrangement, with lightly stained cytoplasm and central nucleus. Granule cells of the dentate gyrus were rounded, packed, dense. Strong GFAP positive immunostaining was detected in the astrocytes in both pyramidal cell and granule cell layers. In treated rats, granule and pyramidal cells in the cerebral cortex and hippocampus were disorganized with signs of degeneration. Faint GFAP positive immunostaining was detected in the astrocytes in granule and pyramidal cell layers. Conclusion: Long-term daily use of topiramate during pregnancy can lead to noticeable pathological neurotoxic effect in the cerebral cortex and hippocampus which may be implicated in cognitive affection. Neurological effect of topiramate necessitates further investigations.

      PubDate: Sun, 02 Feb 2014 09:05:52 GMT
  • Primary Well Differentiated Squamous Cell Carcinoma of Kidney: A Rare

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sunita Singh, Meenu Gill, Ashima Batra, Shruti Semwal, Aarzoo Jahan, Rajeev Sen.
      Cancers of the kidney and renal pelvis are the ninth most common malignant cancer and form the 12th most common cause of all cancer-related deaths. Among malignant renal tumors, squamous cell carcinoma is rare neoplasm and form only about 0.5–8%. We present a case of 60 years old male with complaints of pain in the loin and hematuria for past 2 months. The patient underwent nephrectomy for renal mass on ultrasonography (USG) and computerized tomography (CT) scan, which turned out to be squamous cell carcinoma on histopathological examination.

      PubDate: Wed, 29 Jan 2014 13:20:25 GMT
  • Chernobyl-related Bladder Lesions: New Interpretation Required

    • Abstract: Publication year: 2014
      Source:Journal of Interdisciplinary Histopathology
      Sergei V. Jargin.
      Some aspects of practical pathology in the former Soviet Union, having a potential impact on the diagnostic quality, as well as possible mechanisms of false-positive diagnostics of malignant and premalignant lesions after the Chernobyl accident were discussed previously. In particular, overdiagnosis appears probable in regard to the bladder lesions detected in the radio-contaminated areas. Some studies on the post-Chernobyl bladder lesions are valuable but require new interpretation.

      PubDate: Tue, 28 Jan 2014 01:45:02 GMT
  • False Immunohistochemical Results for Herpesviridae and Other Clusters of
           Differentiation Due To Biotin Intranuclear Inclusions in the Gestational

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Francesco Rivasi, Luca Roncati, Giuseppe Barbolini, Elisabetta Petrella, Renzo Boldorini.
      Objective. There are now eight known human herpes viruses (HHV) containing a double-stranded DNA genome: Herpes Simplex Virus 1 (HSV1, HHV1), Herpes Simplex Virus 2 (HSV2, HHV2), Varicella-Zoster Virus (VZV, HHV3), Epstein-Barr Virus (EBV, HHV4), Cytomegalovirus (CMV, HHV5), Herpes Virus 6 (HHV6-a, HHV6-b), Herpes Virus 7 (HHV7) and Herpes Virus 8 (HHV8, KSHV - Kaposi’s sarcoma associated herpes virus). The highest risk of maternal-fetal HSV transmission is among women who acquire a genital infection during pregnancy. Congenital HHV6 infection occurs in 1% of births, a rate similar to that for CMV infection. Congenital HHV6-a infections are asymptomatic, whereas postnatal HHV6-b infections present with acute febrile states. The purpose of this study was to eliminate false positive results in order to achieve an accurate pathological diagnosis for herpes virus infections to the gestational endometrium. Methods. The biopsies of three suspected cases of gestational herpetic endometritis were submitted to immunohistochemical tests for HHV1+2, HHV5, HHV6-a, HHV6-b, HHV8 and for other clusters of differentiation (CD4, CD8, CD20) in compliance with the ABC method protocol. Samples from the three cases under study were submitted to a real-time polymerase chain reaction (PCR). Results. All three cases exhibited false intranuclear immunohistochemical positivity to the antibodies being used. Conversely, all three reactions tested negative with biotin inactivation. The PCR for herpesviridae, which was positive in the known herpetic controls, showed negative in all three cases. Conclusions. Immunohistochemical investigations of the gestational endometrium (particularly in pregnancies near to term) may yield false results for several herpes viruses, as well as for other immunohistochemical reactions obtained using the ABC method without prior biotin inactivation.

      PubDate: Sat, 14 Sep 2013 16:19:54 GMT
  • Synchronous Bilateral Clear Cell Carcinoma and Papillary Serous
           Cystadenocarcinoma of the Ovaries

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Bhavna Nayal, Mary Mathew, Lakshmi Rao, Bhawna Nagel, Pratap Kumar.
      The presence of synchronous bilateral ovarian malignancy with similar histology is well recognized. The presence of two tumours with different pathology in both the ovaries is extremely uncommon and pose a diagnostic and therapeutic challenge. Only one such case has been reported in a postmenopausal lady. We present second such case with synchronous presence of high grade serous and clear cell carcinoma in a premenopausal woman.

      PubDate: Mon, 25 Mar 2013 05:51:10 GMT
  • Papuloerythroderma of Ofuji in A Young Adult

    • Abstract: Publication year: 2013
      Source:Journal of Interdisciplinary Histopathology
      Mary Mathew, Bhavna Nayal, Raghunath Narayanan Unni, C Balachandran.
      Papuloerythroderma of Ofuji (PEO) is an uncommon skin condition characterized by generalized itchy papular eruptions involving the entire body surface, sparing the major skin folds in the body along with peripheral eosinophilia often asssociated with an malignancy, infection or drug therapy. It usually affects the elderly and very few cases have been reported in young adults. We report a 31 year old male with PEO in the absence of an underlying inciting factor.

      PubDate: Mon, 25 Feb 2013 23:33:28 GMT
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