Journal Cover Advance Laboratory Medicine International
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   ISSN (Print) 2228-8961 - ISSN (Online) 2228-8961
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  • The laboratory diagnosis of dengue virus infection, a review

    • Abstract: Publication year: 2014
      Source:Advance Laboratory Medicine International
      Kameel Mungrue..
      Since no protective vaccine or specific treatments are available for dengue fever accurate diagnosis is critical for the early initiation of specific preventive health measures to curtail epidemic spread and reduce economic losses as well as the timely monitoring of patients to prevent fatalities. Commonly used diagnostic methods for confirming dengue infection involve virus isolation, detection of virus antigen or RNA, and the presence of dengue virus-specific antibodies.

      PubDate: Thu, 05 Dec 2013 07:04:22 GMT
  • Adenosine deaminase and its isoenzyme as a diagnostic marker in tubercular

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Mrinal Pal, Subinay Datta, Chinmoy Ghosh, Partha Sarathi Das, Tarasankar Malik.
      Mortality and residual morbidity is quit high in tubercular meningitis particular in children. Several investigations have been developed for early diagnosis but this sill poses a lot of diagnostic problem in developing countries like India. So, the present study was performed to search a quick and definite investigation for easy and rapid diagnosis of tubercular meningitis and CSF ADA and its isoenzymes activity was selected to differentiate between tubercular and non-tubercular meningitis. Among 57 meningitis patients, 27 were tubercular, 13 were pyogenic, 12 were viral and 6 were cerebral malaria selected. Cerebrospinal fluid total ADA and ADA2 activity were measured and compared with 23 healthy controls and within the infective meningitis. The CSF ADA activity was significantly elevated in all infective meningitis than control (p

      PubDate: Thu, 05 Dec 2013 07:01:45 GMT
  • Pre-preanalytical concerns on the MonoSED - SR for the new MicroSed-SR
           erythrocyte sedimentation rate analyzer

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Sora Yasri.
      The erythrocyte sedimentation rate (ESR) is a time-honored blood test, useful in laboratory medicine. There are several new techniques developed for determination ESR at present. Automated ESR analyzer have been launched for a few years and approved for the laboratory diagnostic property. Here, the authors reported the mechanical consideration and pre-analytical user response to the new Automated ESR analyzer. All of the phlebotomist (8 phlebotomists) noted that this new vacuum tube is not comfortable for usage due to two reasons; a) the length of the tube exceeds the fully extension span between thumb and index fingers and b) the diameter of the tube is too small comparing to the standard needle holder. They said that these two reasons bring the delay in the venipuncture process for 1 – 2 minutes/ cases. The tube length of MonoSed-SR is 2 times about greater than the length of the needle holder and the diameter of MonoSed-SR is about a half of that of the needle holder. These facts make the users felt uncomfortable to use the tube. In addition, mechanical fulcrum can be expected and can bring the failure of venipuncture.

      PubDate: Thu, 31 Oct 2013 02:14:55 GMT
  • Biomarkers for neurofibromatosis

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Faik İlik.
      Biomarkers provide a dynamic and powerful approach to understanding the spectrum of neurological disease with applications in observational and analytic epidemiology, screening, diagnosis and prognosis. Biomarkers would be useful to verify NF1 diagnosis, monitor tumor burden, and/or detect transformation. This brief review describes the major uses of biomarkers in clinical investigation.

      PubDate: Sun, 22 Sep 2013 21:14:28 GMT
  • Serum vaspin and insulin resistance: predictors of steatosis and fibrosis
           in Egyptian patients with genotype 4 chronic hepatitis C

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Ragaa Abdelkader Ramadan.
      Individual variation in the course of chronic hepatitis C (CHC) is remarkable with implication of host, viral and metabolic factors as well as a suggested genotype dependent pattern. Vaspin and leptin, members of adipokines, are involved in regulation of inflammatory response and insulin resistance (IR) which has a potential role in CHC pathogenesis. Vaspin and leptin levels, viral load, and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed in non-diabetic non-cirrhotic CHC-4 Egyptian patients to recognize variables independently associated with IR, steatosis, and fibrosis. This study included 175 subjects; 30 healthy volunteers with age 43.4±4.2 years, and 145 CHC-4 patients with age 44.4±5.4 years. Of the total patients, 55% had steatosis. Seven parameters were significantly associated with IR in CHC-4 patients including; body mass index (BMI), serum AST, TG, vaspin and leptin, and grades of steatosis and fibrosis. Logistic regression analysis identified TG (p=0.01) and fibrosis (p=0.001) as the independent predictors of IR. In multivariate analysis HCV viral load (p=0.03), vaspin (p=0.007), HOMA-IR (p=0.016), and HAI (p=0.009) were independently associated with grades of steatosis. The factors independently associated with liver fibrosis identified by multivariate analysis were BMI (p

      PubDate: Mon, 22 Jul 2013 09:31:18 GMT
  • Antibacterial activity of some natural Duhokian honey against clinical
           isolates of Staphylococcus aureus, Iraq

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Najim Abdulla yassin, Alaa Muyassar Ahmad, Adnan Abdulla Mohammed.
      Antibiotic resistance of bacteria is on the rise, namely multi-resistant Staphylococcus aureus which are resistant to all of the antibiotics in common use. Thus the discovery of alternative theuraptic agents is urgently needed. Honey is an ancient wound treatment that was re-introduced into modern medical practice and possesses therapeutic potential, including wound healing properties and antimicrobial activity. The aim of this study is to investigate and comparison of antibacterial activity of four types of natural honey, found in Duhok city, with commercial one against a multi-resistant Staphylococcus aureus strains isolated from wounds and burns infections in Duhok city, Iraq. Methods A total of 100 wound and burn swabs were collected and analyzed by screened on Blood, Mannitol salt, MacConkey and Nutrient agar followed by the identification of the isolates based on their cultural characteristics and their reactions in standard biochemical tests. All the isolates were tested for antimicrobial susceptibility by the disk diffusion technique according to the Clinical and Laboratory Standards Institute guidelines on Muller Hinton Agar. The antibacterial activity of four natural honeys (agriculture college honey, Barwari Bala , Emadia and Shingal) and one commercial Al-Sheefa honey was evaluated by agar diffusion assay and determination of MIC values. Of the 100 swabs, 25 (25%) swab yielded positive culture of Staphylococcus aureus; the organism exhibited high resistance rates to all used antibiotics. The all natural honeys exhibited highest antibacterial activity than commercial one. Moreover, agriculture college honey had excellent antibacterial activity, at very low concentration 5% (wt/vt) produce inhibition zones, followed by Barwari Bala, Emadia then Sningal honey. Minimal inhibitory concentration (MIC) values of four types of natural honeys were found to be 5, 25, 50 and 50 %(v/v) for AC honey, Barwari Bala, Emadi and Shingal honey respectively. This study highlights that some natural Duhokian honey has complete and partial antibacterial activity when tested in vitro against a multi-resistant Staphylococcus aureus strains isolated from wounds and burns infections.

      PubDate: Sat, 20 Jul 2013 16:49:54 GMT
  • Histopathological examination of all resected gall bladder specimens –
           Requisite or redundant?

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Vani BR, Deepak Kumar B, Srinivasa Murthy V, Padma Priya Kasukurti.
      Unsuspected gall bladder carcinoma constitutes 0.3 to 2.85% of cholecystectomies. In the light of its poor prognosis and aggressive nature, the importance of incidentally diagnosed carcinoma cannot be highlighted enough. This study was undertaken to determine the prevalence of various gall bladder lesions in insured patients of a model hospital and highlighting the need of gallbladder resection. Histopathological study of cholecystectomy specimens was conducted over a period of 2 years. 229 were chronic cholecystits among which 177 were associated with calculi. 27 cases were cholesterolosis, in whom 16 had associated chronic inflammation in the wall induced by calculi. Two cases of adenocarcinoma were detected in clinically and grossly unsuspected cholecystitis cases with associated gall stones (mixed type). Histopathological detection of carcinoma is a gold standard and will continue to be superior to clinical and radiological examination.

      PubDate: Fri, 21 Jun 2013 02:23:16 GMT
  • Blood glucose levels in nephritic syndrome patients undergoing renal

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Ogu Carison, Kim Cheon.
      Nephrotic syndrome is classified as a disease associated with immune impairment. Nephrotic syndrome associated with other metabolic disorders is often manifested in the progression of diabetic nephropathy. In this study, the authors analyzed the prevalence of hyperglycemia in 316 patients suffering from nephrotic syndrome and who were undergoing renal biopsy. According to our study, 34 (10.8%) of the 316 subjects presented hyperglycemia fulfilling criteria for diabetes (fasting blood glucose> 126 mg/dL) and a considerable number of diabetic cases was detected . As intensive management of diabetic nephropathy has not been recorded, the combination of diabetes mellitus and nephrotic syndrome should be looked for in all cases with this syndrome.

      PubDate: Sun, 26 May 2013 23:20:20 GMT
  • Histopathological diagnosis of gastric biopsies in correlation with
           endoscopy – a study in a tertiary care centeR.

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Dr.Kirana Pailoor, Dr.Murali Keshava Sarpangala, Ramesh C.N Naik.
      This study was done to evaluate the histopathological diagnosis of gastric endoscopic biopsies and to correlate the endoscopic and histopathological diagnosis of these neoplastic and non-neoplastic gastric lesions. A total of fifty-two endoscopic biopsies were studied retrospectively. Biopsies were retrieved using flexible fibre – optic endoscope and also video-endoscope. They were transferred to a bottle containing 10% neutral formalin, processed and stained routinely with Haematoxylin and Eosin. Special stains such as Mucicarmine and Giemsa were done as and when required. Out of 52(100%) gastric endoscopic biopsies, 29(56%) were malignant and 23(44%) were benign. The correlation of endoscopic and histopathological diagnosis of these gastric lesions was 57.28%. The sensitivity was 65.96%, specificity 90.57%, positive predictive value 86.11% and negative predictive value was 75%. Endoscopic examination and biopsy is a convenient procedure for accurate objective assessment of patients with symptoms of gastrointestinal tract. Endoscopy is incomplete without biopsy and pathology is the gold standard for the diagnosis of endoscopically detected lesions.

      PubDate: Mon, 22 Apr 2013 22:46:42 GMT
  • Serum concentration of liver function indicators in HIV patients on
           different classes of highly active antiretroviral therapy (HAART)

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Idonije OB, Osadolor HB, Festus OO.
      Soon after the introduction of HAART , drug related toxicities became recognized and well characterized, thus liver toxicity has become a growing problem among HIV patients on HAART hence this study. Liver function was assessed in 290 HIV patients {80 on NNRTIs-based HAART, 80 on NRTIs-based HAART, 80 on PIs-based HAART and 50 newly diagnosed and not on any antiretroviral medication serving as test control} using plasma concentration of alanine transaminase (ALT) and aspartate transaminase (AST) as test indicators. Each of the three groups on HAART were further subdivided into four subgroups of 3, 6, 12 and>12 months based on the duration on HAART with each subgroup consisting of twenty patients. The ALT and AST concentration were determined using standard methods. When the patients on different classes of HAARTS were compared with the control group, the differences in enzyme (ALT and AST) activities were significantly higher in 3 and 6 months duration on HAART for all the three classes of HAART used. The NNRTIs and PIs-based groups also showed a significant difference only in ALT activity in the 12 months duration on HAART. When the ALT and AST activities of patients on NRTIs- based HAART group were compared with the NNRTIs and PIs- based HAART groups, statistically significant differences were observed only in the 3 and 6 months duration on HAART. Conclusively HAART has a duration and drug dependent effects on the liver cells integrity and functions. This effect is lesser with NRTIs as compared with NNRTIs and PIs. It is therefore recommended that routine liver function tests be instituted in HIV patients on HAART regimen.

      PubDate: Wed, 17 Apr 2013 07:08:00 GMT
  • Correlation between fever and leukocyte in dengue infection, a clinical

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Tuk Chea Sovannah, Vein Roun Haang.
      Dengue infection is a major public health problem, affecting general population in the Southeast Asia Region. The hematologic aberration including lymphocytosis, coagulopathy and predominant thrombocytopenia are the common manifestation in the patients with dengue infection. Here, the author reported the experience about fever and leukocyte count of 130 patients with dengue infection who visited the author during endemic season, 2012. The average level of leukocyte among these patients was studied. The correlation between the recorded body temperature of the patients and the leukocyte level was investigated. We found that the fever is common in the patient with dengue infection and the lymphocytosis, not leukocytosis is the common leukocyte disorder in these patients. The correlation between body temperature and total white blood cell count and differential white blood cell count is poor and not significant. Therefore, the fever and the leukocyte disorder in the patients with dengue fever is only a co - presentation.

      PubDate: Sun, 24 Mar 2013 00:55:05 GMT
  • In vitro effect of Ginseng, Ficus fovealata Wall. and Elephantopus scaber
           Linn. on spermatozoa

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Rakshmi Opas Singh, Kandhi Thamma Singh, Pisuth Gutta Prasad.
      Millions of world populations suffer from sexual drive dysfunction in their life. Despite the increasing availability of effective conventional medical treatments, alternative medicine, especially plant-derived and herbal remedies, continue to provide a popular alternative for men and women seeking to improve their sex life. Nevertheless, the efficacy of most herbal agents in treating sexual problems remains uncertain. Here, the author perform an in vitro test to study the effect of three herbs, which are widely used due to the belief that they can promote good sexual activity: Panax Ginseng, Ficus fovealata Wall., and Elephantopus scaber Linn. We found that the spermatic count and motility rate in the Ficus fovealata Wall., and Elephantopus scaber Linn. - added samples were lower than controls but the Ginseng – added were higher than the control.

      PubDate: Sun, 24 Mar 2013 00:33:13 GMT
  • Osteoporosis associated with aromatase inhibitors is different from
           post-menopausal osteoporosis

    • Abstract: Publication year: 2013
      Source:Advance Laboratory Medicine International
      Hasan Mutlu, Tuncay Aslan, Güler Silov Yılmaz, Abdülsamet Erden, Yasemin Benderli Cihan, Zeki Akca, Arzu Aksahin, Abdullah Büyükçelik.
      Osteoporotic effects are one of the known side effects of aromatase inhibitors that are used in the treatment of breast cancer. In our study, osteopenia and osteoporosis associated with the use of aromatase inhibitors were examined for their difference compared to postmenopausal osteopenia and osteoporosis. Total 84 patients admitted to Kayseri Training and Research Hospital and Mersin State Hospital were included in the study. 103 patients without any malignancy were enrolled as control group. Dual energy x-ray absorptiometry (DXA) results of the groups were compared. There was significant difference between the groups when the regions with the lowest bone mineral density were compared and femoral involvement was more prevalent in patients on aromatase inhibitors compared to the other group (p=0,014). Furthermore, there was significant difference for the regions with the lowest bone density in femur (p=0,015). Osteopenic and osteoporotic response in patients using aromatase inhibitors is different from the patients who do not use aromatase inhibitors and femoral region is more commonly affected compared to the other regions.

      PubDate: Thu, 20 Dec 2012 01:23:47 GMT
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