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Journal Cover Acta Informatica Medica
  [SJR: 0.217]   [H-I: 4]   [0 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 0353-8109 - ISSN (Online) 1986-5988
   Published by ScopeMed Homepage  [99 journals]
  • The Most Influential Scientists in the Development of Medical informatics
           (12): Joshua Lederberg

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Izet Masic.


      PubDate: Fri, 03 Jun 2016 22:07:23 GMT
       
  • Ectopic Origin of Coronary Arteries Diagnozed by Coronary Angiography

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Xhevdet Krasniqi, Daut Gorani, Basri Sejdiu, Hajdin Citaku.
      Introduction: Anomalous origin of coronary arteries from opposite sinus of Valsalva is rare finding. The incidence of anomalous origination of the left coronary artery from right sinus is 0.15% and the right coronary artery from the left sinus is 0.92%. The ectopic origin of left coronary artery or right coronary artery from opposite sinus depending on pathways and considering atherosclerotic changes are manifested with different clinical significance. Case report: We report two cases, the first case the coronary angiography showed the left coronary artery arising from the right coronary sinus, presenting with proximally and distally stenosed left anterior descending artery (LAD), associated with medial and distal stenosed right coronary artery (RCA). The second case the coronary angiography revealed the right coronary artery arising from the left coronary sinus, associated with tortuous medial and distal segments of left anterior descending artery (LAD), without atherosclerotic changes. The first case successfully underwent treatment procedures based on guidelines for revascularization. Conclusion: The coronary angiography of patients with coronary ischemia determines atherosclerotic disease with possibility of the presence of coronary artery anomalies that in cases with ectopic origin from opposite sinus continues to exist as a challenge during treatment in interventional cardiology.

      PubDate: Fri, 03 Jun 2016 22:06:25 GMT
       
  • Radiological Findings of Michel Aplasia

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Ayse Umul, Hakan Demirtas, and Ahmet Orhan Celik.
      Introduction: Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. Case report: We have discussed here that three year old girl diagnosed Michel aplasia with temporal bone computed tomography (CT) and temporal magnetic resonance imaging (MRI) findings.

      PubDate: Fri, 03 Jun 2016 22:05:17 GMT
       
  • Application of Agree II Instrument for Appraisal of Postpartum Hemorrhage
           Clinical Practice Guidelines in Bosnia and Herzegovina

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Ahmed Novo, Andreja Subotic-popovic, Savka Strbac, Alma Kandic, and Mihai Horga.
      Introduction: Federal Minister of Health and Minister of Health and Social Welfare of the Republika Srpska as a Governmental health authorities in Federation of Bosnia and Herzegovina (FBiH) and the Republika Srpska nominated/appointed health professionals as their representatives to a multidisciplinary Guidelines Adaptation Group (GAG). This group started with its work in September 2015. The main purpose of the guidelines development exercise is to develop guidelines with worldwide recognized methodology for clinical guidelines development and adaptation. At the end of this consultancy, GAG would have develop a clinical practice guideline on Postpartum hemorrhage (PPH) through the adaptation method, starting from published international clinical guidelines and adapting it according to the country specific requirements. Methodology: During the process of identifying the best guideline for adaptation, the GAG had to pass several steps. One of the crucial steps was to identify the questions related to clinical practice and health policy for which answers are needed to be addressed by the guideline. These questions included relevant issues regarding the topic area such as diagnosis, prognosis, intervention, service delivery, and training. After that, six guidelines have been researched by the six members of the GAG to see if they answered the identified questions. Evaluating the methodological quality of the selected clinical guidelines was a second essential step before deciding which ones could best fit the needs and interests. AGREE II instrument has been chosen as methods for evaluating clinical guideline quality and appropriateness. Four appraisers conducted the assessment of each of the selected guidelines for PPH. All appraisers passed the training for the AGREE II instrument before conducting appraisals, as recommended by the AGREE collaboration. Each of the four guidelines was rated independently with the AGREE II tool by each appraiser. Results: The highest score was obtained by the WHO recommendations for postpartum hemorrhage guidelines and each of four assessors recommended it to be adapted and further implemented. Discussion: In spite of several serous attempts and two Agencies for quality improvement in BiH the whole process of guideline adaptation is still in the beginning and therefore the establishment of a strong connection with similar institutions and organizations from our region and the rest of the world is very important. Cooperation and collaboration across institutions and countries and key stakeholders have potential to significantly improve the validity and quality of the adapted guidelines and to positively influence implementation.

      PubDate: Fri, 03 Jun 2016 22:04:13 GMT
       
  • Recommendations for Using Barcode in Hospital Process

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Peyman Rezaei Hachesu, Leila Zyaei‚ and Hadi Hassankhani.
      Background: Lack of attention to the proper barcode using leads to lack of use or misuse in the hospitals. The present research aimed to investigate the requirements and barrier for using barcode technology and presenting suggestions to use it. Methods: The research is observational-descriptive. The data was collected using the designed checklist which its validity was assessed. This check list consists of two parts: “Requirements” and “barrier” of using the barcodes. Research community included 10 teaching hospitals and a class of 65 participants included people in the hospitals. The collected data was analyzed using descriptive statistics. Results: Required changes of workflow processes in the hospital and compliance them with the hospital policy are such requirements that had been infringed in the 90 % of hospitals. Prioritization of some hospital processes for barcoding, system integration with Hospital Information system (HIS), training of staff and budgeting are requirements for the successful implementation which had been infringed in the 80% of hospitals. Dissatisfaction with the quality of barcode labels and lacks of adequate scanners both whit the rate of 100 %, and the lack of understanding of the necessary requirements for implementation of barcodes as 80% were the most important barrier. Conclusion: Integrate bar code system with clinical workflow should be considered. Lack of knowledge and understanding toward the infrastructure, inadequate staff training and technological problems are considered as the greatest barriers.

      PubDate: Fri, 03 Jun 2016 22:03:02 GMT
       
  • Documentation of Medical Records in Hospitals of Mazandaran University of
           Medical Sciences in 2014: a Quantitative Study

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Benyamin Mohseni Saravi, Zolaykha Asgari, Hasan Siamian, Ebrahim Bagherian Farahabadi, Alimorad Heidari Gorji, Nima Motamed, Mohammad Fallahkharyeki, Ramin Mohammadi.
      Introduction: Documentation of patient care in medical record formats is always emphasized. These documents are used as a means to go on treating the patients, staff in their own defense, assessment, care, any legal proceedings and medical science education. Therefore, in this study, each of the data elements available in patients’ records are important and filling them indicates the importance put by the documenting teams, so it has been dealt with the documentation the patient records in the hospitals of Mazandaran province. Method: This cross-sectional study aimed to review medical records in 16 hospitals of Mazandaran University of Medical Sciences (MazUMS). In order to collection data, a check list was prepared based on the data elements including four forms of the admission, summary, patients’ medical history and progress note. The data recording was defined as “Yes” with the value of 1, lack of recording was defined as “No” with the value of 2, and “Not applied” with the value of 0 for the cases in which the mentioned variable medical records are not applied. Results: The overall evaluation of the documentation was considered as 95-100% equal to “good”, 75-94% equal to “average” and below -75% equal to “poor”. Using the stratified random sample volume formula, 381 cases were reviewed. The data were analyzed by the SPSS version 19 and descriptive statistics. Results: The results showed that %62 of registration and all the four forms were in the “poor” category. There was no big difference in average registration among the hospitals. Among the educational groups Gynecology and Infectious were equal and had the highest average of documentation of %68. In the data categories, the highest documentation average belonged to the verification, %91. Conclusion: According to the overall assessment in which the rate of documentation was in the category “week”, we should make much more efforts to reach better conditions. Even if a data element is recognized meaningless, unnecessary and repetitive by the in charge of documentation, it should not be neglected and skipped. In order to solve the problems of these types, it is suggested to discuss the medical records forms and elements that seem unnecessary in the related committees.

      PubDate: Fri, 03 Jun 2016 22:01:51 GMT
       
  • Investigation of the Impact of Extracting and Exchanging Health
           Information by Using Internet and Social Networks

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      John Pistolis, Stelios Zimeras, Kostas Chardalias, Zoe Roupa, George Fildisis, and Marianna Diomidous.
      Introduction: Social networks (1) have been embedded in our daily life for a long time. They constitute a powerful tool used nowadays for both searching and exchanging information on different issues by using Internet searching engines (Google, Bing, etc.) and Social Networks (Facebook, Twitter etc.). In this paper, are presented the results of a research based on the frequency and the type of the usage of the Internet and the Social Networks by the general public and the health professionals. Objectives: The objectives of the research were focused on the investigation of the frequency of seeking and meticulously searching for health information in the social media by both individuals and health practitioners. The exchanging of information is a procedure that involves the issues of reliability and quality of information. Methods: In this research, by using advanced statistical techniques an effort is made to investigate the participant’s profile in using social networks for searching and exchanging information on health issues. Results: Based on the answers 93 % of the people, use the Internet to find information on health-subjects. Considering principal component analysis, the most important health subjects were nutrition (0.719 %), respiratory issues (0.79 %), cardiological issues (0.777%), psychological issues (0.667%) and total (73.8%). Conclusions: The research results, based on different statistical techniques revealed that the 61.2% of the males and 56.4% of the females intended to use the social networks for searching medical information. Based on the principal components analysis, the most important sources that the participants mentioned, were the use of the Internet and social networks for exchanging information on health issues. These sources proved to be of paramount importance to the participants of the study. The same holds for nursing, medical and administrative staff in hospitals.

      PubDate: Fri, 03 Jun 2016 22:00:42 GMT
       
  • Mobile Phone Based System Opportunities to Home-based Managing of
           Chemotherapy Side Effects

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Somayeh Davoodi, Zeinab Mohammadzadeh, and Reza Safdari.
      Objective: Applying mobile base systems in cancer care especially in chemotherapy management have remarkable growing in recent decades. Because chemotherapy side effects have significant influences on patient’s lives, therefore it is necessary to take ways to control them. This research has studied some experiences of using mobile phone based systems to home-based monitor of chemotherapy side effects in cancer. Methods: In this literature review study, search was conducted with keywords like cancer, chemotherapy, mobile phone, information technology, side effects and self managing, in Science Direct, Google Scholar and Pub Med databases since 2005. Results: Today, because of the growing trend of the cancer, we need methods and innovations such as information technology to manage and control it. Mobile phone based systems are the solutions that help to provide quick access to monitor chemotherapy side effects for cancer patients at home. Investigated studies demonstrate that using of mobile phones in chemotherapy management have positive results and led to patients and clinicians satisfactions. Conclusion: This study shows that the mobile phone system for home-based monitoring chemotherapy side effects works well. In result, knowledge of cancer self-management and the rate of patient’s effective participation in care process improved.

      PubDate: Fri, 03 Jun 2016 21:59:31 GMT
       
  • Conceptual Framework for Developing a Diabetes Information Network

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Hossein Riazi, Mostafa Langarizadeh, Bagher Larijani, and Leila Shahmoradi.
      Objective: To provide a conceptual framework for managing diabetic patient care, and creating an information network for clinical research. Background: A wide range of information technology (IT) based interventions such as distance learning, diabetes registries, personal or electronic health record systems, clinical information systems, and clinical decision support systems have so far been used in supporting diabetic care. Previous studies demonstrated that IT could improve diabetes care at its different aspects. There is however no comprehensive conceptual framework that defines how different IT applications can support diverse aspects of this care. Therefore, a conceptual framework that combines different IT solutions into a wide information network for improving care processes and for research purposes is widely lacking. In this study we describe the theoretical underpin of a big project aiming at building a wide diabetic information network namely DIANET. Research design and methods: A literature review and a survey of national programs and existing regulations for diabetes management was conducted in order to define different aspects of diabetic care that should be supported by IT solutions. Both qualitative and quantitative research methods were used in this study. In addition to the results of a previous systematic literature review, two brainstorming and three expert panel sessions were conducted to identify requirements of a comprehensive information technology solution. Based on these inputs, the requirements for creating a diabetes information network were identified and used to create a questionnaire based on 9-point Likert scale. The questionnaire was finalized after removing some items based on calculated content validity ratio and content validity index coefficients. Cronbach’s alpha reliability coefficient was also calculated (αTotal= 0.98, P

      PubDate: Fri, 03 Jun 2016 21:58:05 GMT
       
  • Semantic-Web Architecture for Electronic Discharge Summary Based on OWL
           2.0 Standard

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Shahram Tahmasebian, Mostafa Langarizadeh, Marjan Ghazisaeidi, and Reza Safdari.
      Introduction: Patients’ electronic medical record contains all information related to treatment processes during hospitalization. One of the most important documents in this record is the record summary. In this document, summary of the whole treatment process is presented which is used for subsequent treatments and other issues pertaining to the treatment. Using suitable architecture for this document, apart from the aforementioned points we can use it in other fields such as data mining or decision making based on the cases. Material and Methods: In this study, at first, a model for patient’s medical record summary has been suggested using semantic web-based architecture. Then, based on service-oriented architecture and using Java programming language, a software solution was designed and run in a way to generate medical record summary with this structure and at the end, new uses of this structure was explained. Results: in this study a structure for medical record summaries along with corrective points within semantic web has been offered and a software running within Java along with special ontologies are provided. Discussion and Conclusion: After discussing the project with the experts of medical/health data management and medical informatics as well as clinical experts, it became clear that suggested design for medical record summary apart from covering many issues currently faced in the medical records has also many advantages including its uses in research projects, decision making based on the cases etc.

      PubDate: Fri, 03 Jun 2016 21:56:57 GMT
       
  • One Year Follow-Up After Veriflex Phakic Intraocular Lenses Implantation
           for Correction of Myopia

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Melisa Ahmedbegovic Pjano, Alma Biscevic, Senad Grisevic, Ajla Pidro, Mirko Ratkovic, Maja Bohac, Amila Alikadic Husovic, Refet Gojak.
      Objectives: The aim of this study was to evaluate visual and refractive outcomes after Veriflex phakic intraocular lenses (pIOL) implantation in moderately myopic eyes as well as postoperative complications. Methods: This prospective clinical study included 40 eyes of 26 patients which underwent implantation of Veriflex for correction of myopia from -6.00 to -14.50 diopters (D) in the Eye Clinic Svjetlost Sarajevo, from January 2011 to January 2014. Uncorrected distance visual acuity (UDVA), manifest residual spherical equivalent (MRSE), intraocular pressure (IOP), endothelial cell (EC) density were evaluated at one, three, six and 12 months. Other complications in postoperative period were evaluated. For statistical analysis SPSS for Windows and Microsoft Excel were used. Results: Out of 26 patients 14 had binocular and 12 monocular procedure, with mean age of 29.8±6.5 years. After 12 months mean UDVA was 0.73±0.20. Mean MRSE was -0.39±0.31D and 90% of eyes had MRSE within ±1D. EC loss was 7.18±4.33%. There was no significant change of IOP by the end of 12 months follow up period. The only intraoperative complication was hyphema and occurred in one eye. Few postoperative complications were: subclinical inflammation in three eyes (7,5%), pigment dispersion in four eyes (10%), ovalisation of papilla in 2 eyes (5%) and decentration of pIOL in 2 eyes (5%). Conclusion: Implantation of iris-claw phakic lenses Veriflex for treating moderately high myopia is a procedure with good visual and refractive results and few postoperative complications.

      PubDate: Fri, 03 Jun 2016 21:55:08 GMT
       
  • Echocardiographic Assessment of Ischaemic Mitral Regurgitation, Mechanism,
           Severity, Impact on Treatment Strategy and Long Term Outcome

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Nabil Naser, Alen Dzubur, Zumreta Kusljugic, Katarina Kovacevic, Mehmed Kulic, Sekib Sokolovic, Ibrahim Terzic, Ilirijana Haxihibeqiri-Karabdic, Zorica Hondo, Snjezana Brdzanovic, and Sanja Miseljic.
      Introduction: The commonest mitral regurgitation etiologies are degenerative (60%), rheumatic post-inflammatory, 12%) and functional (25%). Due to the large number of patients with acute MI, the incidence of ischaemic MR is also high. Ischaemic mitral regurgitation is a complex multifactorial disease that involves left ventricular geometry, the mitral annulus, and the valvular/subvalvular apparatus. Ischaemic mitral regurgitation is an important consequence of LV remodeling after myocardial infarction. Research Objectives: The objective of this study is to determine the role of echocardiography in detecting and assessment of mitral regurgitation mechanism, severity, impact on treatment strategy and long term outcome in patients with myocardial infarction during the follow up period of 5 years. Also one of objectives to determine if the absence or presence of ischaemic MR is associated with increased morbidity and mortality in patients with myocardial infarction. Patients and methods: The study covered 138 adult patients. All patients were subjected to echocardiography evaluation after acute myocardial infarction during the period of follow up for 5 years. The patients were examined on an ultrasound machine Philips iE 33 xMatrix, Philips HD 11 XE, and GE Vivid 7 equipped with all cardiologic probes for adults and multi-plan TEE probes. We evaluated mechanisms and severity of mitral regurgitation which includes the regurgitant volume (RV), effective regurgitant orifice area (EROA), the regurgitant fraction (RF), Jet/LA area, also we measured the of vena contracta width (VC width cm) for assessment of IMR severity, papillary muscles anatomy and displacement, LV systolic function ± dilation, LV regional wall motion abnormality WMA, LV WMI, Left ventricle LV remodeling, impact on treatment strategy and long term mortality. Results: We analyzed and follow up 138 patients with previous (>16 days) Q-wave myocardial infarction by ECG who underwent TTE and TEE echocardiography for detection and assessment of ischaemic mitral regurgitation (IMR) with baseline age (62 ± 9), ejection fraction (EF 41±12%), the regurgitant volume (RV) were 42±21 mL/beat, and effective regurgitant orifice area (EROA) 20±16 mm2, the regurgitant fraction (RF) were 48±10%, Jet/LA area 47±12%. Also we measured the of vena contracta width (VC width cm) 0,4±0,6 for assessment of IMR severity. During 5 years follow up, total mortality for patients with moderate/severe IMR–grade II-IV (54.2±1.8%) were higher than for those with mild IMR–grade I (30.4±2.9%) (P

      PubDate: Fri, 03 Jun 2016 21:53:44 GMT
       
  • A New Measurement Equivalence Technique Based on Latent Class Regression
           as Compared with Multiple Indicators Multiple Causes

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Jamshid Jamali, Seyyed Mohammad Taghi Ayatollahi, and Peyman Jafari.
      Background: Measurement equivalence is an essential prerequisite for making valid comparisons in mental health questionnaires across groups. In most methods used for assessing measurement equivalence, which is known as Differential Item Functioning (DIF), latent variables are assumed to be continuous. Objective: To compare a new method called Latent Class Regression (LCR) designed for discrete latent variable with the multiple indicators multiple cause (MIMIC) as a continuous latent variable technique to assess the measurement equivalence of the 12-item General Health Questionnaire (GHQ-12), which is a cross deferent subgroup of Iranian nurses. Methods: A cross-sectional survey was conducted in 2014 among 771 nurses working in the hospitals of Fars and Bushehr provinces of southern Iran. To identify the Minor Psychiatric Disorders (MPD), the nurses completed self-report GHQ-12 questionnaires and sociodemographic questions. Two uniform-DIF detection methods, LCR and MIMIC, were applied for comparability when the GHQ-12 score was assumed to be discrete and continuous, respectively. Results: The result of fitting LCR with 2 classes indicated that 27.4% of the nurses had MPD. Gender was identified as an influential factor of the level of MPD.LCR and MIMIC agree with detection of DIF and DIF-free items by gender, age, education and marital status in 83.3, 100.0, 91.7 and 83.3% cases, respectively. Conclusions: The results indicated that the GHQ-12 is to a great degree, an invariant measure for the assessment of MPD among nurses. High convergence between the two methods suggests using the LCR approach in cases of discrete latent variable, e.g. GHQ-12 and adequate sample size.

      PubDate: Fri, 03 Jun 2016 21:52:16 GMT
       
  • Imaging Characteristics and Prevalence of Pancreatic Carcinoma in Kosovo
           During 2011-2015 - Diagnostic Method as Choice

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Kreshnike Dedushi, Serbeze Kabashi, Sefedin Mucaj, Gazmed Hasbahta, Naser Ramadani, and Astrit Hoxhaj.
      Introduction: Pancreatic cancer is the 10th most common malignancy and the 4th largest cancer killer in adults. Aim: The purpose of this paper is to evaluate the number of cases presented with pancreatic carcinoma during the years 2011-2015, our experience of the imaging characteristics of pancreatic carcinoma. We evaluated prevalence of the pancreatic cancers, distant metastases and other local infiltration signs among the total cases of the pancreatic cancers diagnosed in the University Clinical Center of Kosovo, with the aim to compare these research findings to similar studies made in the developed countries. This is a retrospective research study done during the period of 2011-2015. Materials and Methodology: This retrospective research study includes 362 patients recently diagnosed with pancreatic cancer, examined in the period of 2011-2015 at the University Clinical Center of Kosovo. The imaging diagnostics are performed with MSCT Sensation 64 Siemens, MSCT Emotion 6 Siemens, and 1.5T MRI Symphony Siemens, biopsy guide with MSCT Sensation 64 Siemens in the Radiologic Clinic of UCCK; while the histopathology diagnostics has been performed in Clinic of Pathology at UCCK and prevalence is taken from the number of cases Reported at the Institute of Oncology Institute of Statistics and NIPH (National Institute of Public Health of Kosovo). Results: Out of a total of the 362 patients diagnosed with pancreas cancer, results is female 39.5% (n=143) and male 61.5% (n=219), report M: F (1: 1.6), 286 cases resulted in head and neck 79 % (n=286), 76 cases resulted in body and tail cancers (21%), distant metastases in first imaging modality were found in(n=155) patients 43 %, local infiltration was found in patients: gastric infiltration 15 % (n=54), duodenal and papilla infiltration 26% (n=94), local infiltration spleen 16% (n=57), local infiltration mesentery 43 % (n= 155), dilated biliary tree 34 % (n=123), regional lymph node infiltration 83 % (n= 300). Out of a total of the 362 patients diagnosed with pancreas cancer, 346 cases resulted> 2 cm and 16 cases resulted < 2 cm and with component cystic was 41.2 % ( n = 149), solid with component cystic – necrotic 33% (n= 119), solid 25.7% (n= 93). The prevalence is 19.9: 100,000 inhabitants. Conclusions: Prevalence of carcinoma of the pancreas for 5 years in Kosovo has proved to be prevalence is 19.9: 100,000 inhabitants. Seventy-four percent (74 %, n= 268) of all cancers are found in Stage III and IV. From an imaging point of view, these cancers were presented in an advanced stage, mainly due to their late clinical symptoms and limited access to imaging methods in our country.

      PubDate: Fri, 03 Jun 2016 21:50:55 GMT
       
  • Usefulness of Total PSA Value in Prostate Diseases Diagnosis

    • Abstract: 2016-06-08T23-15-24Z
      Source: Acta Informatica Medica
      Alden Prcic, Edin Begic, and Mustafa Hiros.
      Introduction: Analysis of total value of prostate specific antigen (PSAT), with the unavoidable digital rectal examination (DRE) is the basis of prostate cancer detection. Aim: The aim of this study was to determine the specificity and sensitivity of the total value of PSAT in the diagnosis of prostate cancer. The aim was also to determine the significance of PSAT in diagnosis of benign prostate hyperplasia, precancerous conditions and inflammatory and atrophic changes of the prostate. Material and methods: Data were collected from the “Register of PH biopsy” of Clinic of Urology, CCU Sarajevo. Results: Analysis of correlation between the diagnosis and the PSAT value shows statistically significant negative correlation (r =-0,186; p = 0.006) in the sense that the value of the PSAT is highest in cancer patients, and the lowest in patients with benign prostatic hyperplasia. PSAT increases with age (r = 0.152; p = 0.025). For prostate cancer optimal sensitivity and specificity for PSAT value occurs at cut off value of> 8.6 ng /mL. Values lower than 2 ng/mL and higher than 10 ng/mL are most specific, and PPV increases with increasing value of PSAT. PSAT at values of 10 ng/mL are at high levels of specificity, and value> 10 ng / mL is also of high sensitivity in the detection of prostate cancer, and in this moment these values represent the optimal mode for the subsequent treatment. Conclusion: PSAT has a relative significance in the detection of prostate cancer, and should not be used as a guideline without DRE.

      PubDate: Fri, 03 Jun 2016 21:49:28 GMT
       
  • Investigation of the Impact of Extracting and Exchanging Health
           Information by Using Internet and Social Networks

    • Abstract: 2016-04-06T20-37-13Z
      Source: Acta Informatica Medica
      John Pistolis, Stelios Zimeras, Kostas Chardalias, Zoe Roupa, George Fildisis, Marianna Diomidous.
      Introduction: Social networks (1) are embedded in our daily life a long time ago. They constitute a powerful tool (1, 2) used nowadays for both searching and exchanging information on different issues by using internet searching engines (Google, Facebook, e.t.c.). In this paper, a research is presented based on the issue of the usage of internet & social networks by the general public and the health professionals. Objectives: The objective was to investigate the frequency of seeking and meticulously searching for health information in the social media by both individuals and health practitioners. The exchanging of information is a procedure that involves the issues of reliability and quality of information (1). Methods: In this work, by using advanced statistical techniques an effort is made to investigate the participant’s profile in using social networks for digging and exchanging information on health issues. Results: Based on the answers 93 % of the people are using the internet for finding information on health-subjects. Considering principal component analysis, the most important subjects were nutrition (0.719 %), respiratory issues (0.79 %), cardiological issues (0.777%), psychological issues (0.667%) and total (73.8 %). Conclusions: On the final conclusion, based on different statistical techniques, the findings were that the 61.2% of the males and 56.4% of the females indented to use the social networks for searching medical information. Based on the principal components analysis, the most important human-sources that people mentioned, those on the use of internet and social networks for exchanging information on health issues is of paramount importance. The same holds for nursing, medical and administrative staff in hospitals.

      PubDate: Sat, 02 Apr 2016 11:27:21 GMT
       
  • The Most Influential Scientist in the Development of Medical informatics
           (11): David B. Shires

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Izet Masic.


      PubDate: Sat, 26 Mar 2016 08:55:50 GMT
       
  • MRI Verification of a Case of Huge Infantile Rhabdomyoma

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Naser Ramadani, Kreshnike Dedushi Kreshnike, Sefedin Muçaj, Serbeze Kabashi, Astrit Hoxhaj, Naim Jerliu, Ramush Bejiçi.
      Introduction: Cardiac rhabdomyoma is type of benign myocardial tumor that is the most common fetal cardiac tumor. Cardiac rhabdomyomas are usually detected before birth or during the first year of life. They account for over 60% of all primary cardiac tumors. Case report: A 6 month old child with coughing and obstruction in breathing, was hospitalized in the Pediatric Clinic in UCCK, Pristine. The difficulty of breathing was heard and the pathological noise of the heart was noticed from the pediatrician. In the echo of the heart at the posterior and apico-lateral part of the left ventricle a tumoral mass was presented with the dimensions of 56 x 54 mm that forwarded the contractions of the left ventricle, the mass involved also the left ventricle wall and was not vascularized. The right ventricle was deformed and with the shifting of the SIV on the right the contractility was preserved. Aorta, the left arch and AP were normal with laminar circulation. The pericard was presented free. Radiography of thoracic organs was made; it resulted on cardiomegaly and significant bronchovascular drawing. It was completed with an MRI and it resulted on: Cardiomegaly due to large tumoral mass lesion (60x34 mm) involving lateral wall of left ventricle. It was isointense to the muscle on T1W images, markedly hyperintense on T2W images. There were a few septa or bant like hypointensities within lesion. On postcontrast study it showed avid enhancement. The left ventricle volume was decreased. Mild pericardial effusion was also noted. Surgical intervention was performed and it resulted on the histopathological aspect as a huge infantile rhadbomyoma. Conclusion: In most cases no treatment is required and these lesions regress spontaneously. Patients with left ventricular outflow tract obstruction or refractory arrhythmias respond well to surgical excision. Rhabdomyomas are frequently diagnosed by means of fetal echocardiography during the prenatal period.

      PubDate: Sat, 26 Mar 2016 08:55:10 GMT
       
  • Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Lidvana Spahiu, Haki Jashari, Vjosa Mulliqi-Kotori, Blerta Elezi-Rugova, Besart Merovci.
      Introduction: Hypothyroidism has been reported to affect renal function and structure. However, the association of hypothyroidism with distal renal tubular acidosis (dRTA) is rarely reported in children. Case Presentation: We present a 6-year-boy with Down syndrome admitted in our department due to vomiting, weakness, polyuria, polydipsia, irritability and weight loss in the last few weeks. Investigations revealed features of hypokalemia, metabolic acidosis and alkaline urine consistent with dTRA. Abdominal ultrasound found nephrocalcinosis. In addition, Antithyroid peroxidase antibodies were positive, suggesting an autoimmune background for the pathogenesis of the tubular dysfunction. Treatment for dRTA and hypothyroidism was started and symptomatic improve was noticed. Conclusion: dRTA should be excluded in children with autoimmune disorders who develop weakness, polyuria, polydipsia or growth failure. Early diagnosis would reduce long-term complications.

      PubDate: Sat, 26 Mar 2016 08:52:39 GMT
       
  • Bariatric Surgery in University Clinic Center Tuzla - Results After 30
           Operations

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Amir Ahmetasevic, Fuad Pasic, Miroslav Bekavac Beslin, Miroslav Ilic, Dzenita Ahmetasevic, Mirza Mesic.
      Introduction: Project of Bariatric surgery in University clinic center (UCC) Tuzla has been initiated in 2009 as an idea of professor Dešo Mešić and soon after that Bariatric surgical team led by doctor Fuad Pasic has been created. Material and methods: Practical team education was realized in Croatia in hospital „Sisters of Mercy“ under supervision of professor Miroslav-Bekavac Beslin. First bariatric operations in UCC Tuzla has been done in 2011 and it was biliopancreatic diversion (BPD) Scopinaro. Results and discussion: So far there has been done 30 operations and among them there have been used almost all operative modalities - restrictive, malabsorptive and combined (laparoscopic gastric banding-LAPGB, Roux-y mini gastric bypass,open and laparoscopic gastric sleeve resection, and over mentioned Scopinaro’s BPD). Beginning results are very promising according to the fact that almost all operated patients after one year stopped using antihypertensive, antidiabetic and antidepressant therapy, that average year’s weight loss is 35-100 kilograms and total satisfactions of patients after surgeries is obvious.

      PubDate: Sat, 26 Mar 2016 08:51:01 GMT
       
  • Social Network Sites as Educational Factors

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Alireza Ebrahimpour, Farnaz Rajabali, Fatemeh Yazdanfar, Reza Azarbad, Majid Rezaei Nodeh, Hasan Siamian, Mohammad Vahedi.
      Background: in this present era, the technology development has established certain type of communication. Nowadays education as the fundamental principle in transferring cognition to the learners has found various methods. Recently the concept that social networks could be effective tool in easing the achievement to the educational goals has been under attention. Therefore, this investigation is trying to find out whether, the social networks could play role on the process of education among students' Materials and Methods: This cross sectional descriptive study was performed on 1000 students from 7 medical universities in 2015. The data collection tool was questionnaire that was approved Cronbach’s alpha was 0.85. Meanwhile its validity was confirmed too. The obtained data were analyzed by the descriptive statistic, ANOVA, Turkey and used X2 SPSS-19. Results: In this investigation, 940 subjects were under study. 85% used daily the social network. The highest usage was attributed to the Telegram. 52% preferred image suitable for transferring of information. Even though, 73% believed that these networks have significant effects on coordinating of students with in university charges. Conclusion: Considering the findings of the present study, it is proposed that the universities integrate the social networks in the education programs and recognize it as the awareness factor, therefore benefit it in the educational affairs.

      PubDate: Sat, 26 Mar 2016 08:41:31 GMT
       
  • Quality of Public Hospitals Websites: A Cross-Sectional Analytical Study
           in Iran

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Salarvand Shahin, Samadbeik Mahnaz, Tarahi Mohammad Javad, Salarvand Hamed.
      Introduction: Nowadays, hospitals have turned increasingly towards the Internet and develop their own web presence. Hospital Websites could be operating as effective web resources of information and interactive communication mediums to enhance hospital services to the public. Aim: Therefore, the aim of this study was to assess the quality of websites in Tehran’s public hospitals. Material and methods: This cross-sectional analysis involved all public hospitals in Iran’s capital city, Tehran, with a working website or subsites between April and June, 2014 (N=59). The websites were evaluated using three validated instruments: a localized checklist, Google page rank, and the Alexa traffic ranking. The mentioned checklist consisted of 112 items divided into five sections: technical characteristics, hospital information and facilities, medical services, interactive on-line services and external activities. Data were analyzed using descriptive and analytical statistics. Results: The mean website evaluation score was 45.7 out of 224 for selected public hospitals. All the studied websites were in the weak category based on the earned quality scores. There was no statistically significant association between the website evaluation score with Google page rank (P=0.092), Alexa global traffic rank and Alexa traffic rank in Iran (P>0.05). The hospital websites had a lower quality score in the interactive online services and external activities criteria in comparing to other criteria. Due to the low quality level of the studied websites and the importance of hospital portals in providing information and services on the Internet, the authorities should do precise planning for the appreciable improvement in the quality of hospital websites.

      PubDate: Sat, 26 Mar 2016 08:40:12 GMT
       
  • Accreditation of Management Communication and Information Systems in
           Public Hospitals of Sabzevar City, Iran

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Fereshteh Farzianpour, Saeed Shojaei, Mohammad Arab, Abbas Rahimi Foroushani.
      Objective: Information systems are “computer systems that collect, store, process, retrieve, show, and provide timely information required in practice, education, management, and research”. The purpose of these systems is to support hospital activities in practical, tactical, and strategic levels in order to provide better service to patients. This study aimed to evaluate the communication and information system (MCI) in public hospitals in Sabzevar city in 2014 from the perspective of human resources according to international standards of the Joint Commission Accreditation Hospital (JCAH). Methods: This study was a practical, descriptive, cross-sectional study. The study population consisted of Sabzevar nurses who used hospital information system. Sampling was done by classification method and in proportion to the number of nurses in each health care units in hospitals in 2014. The sample size was 200 and after referring to hospitals, 200 questionnaires were completed. Sample size was calculated by the formula n=Z2P (1-P)/d2 with P=0.5, α=0.05, d=0.05, and Z=1.96. Data collection tool was the questionnaire of assessment of hospital information systems of JCAH, which has 124 specific questions, including 6 areas. To assess the effect of demographic variables with MCI standards of two questionnaires (feasibility and implementation), the following steps were taken. 1. Kolmogorov-Smirnov test was used to determine whether responses were normal or not. 2. In case of normal data, t-test was used for dual groups and one-way ANOVA test for groups of three or more. 3. If not normal, Mann-Whitney test was used for dual groups and Kruskal-Wallis test for groups of three or more. Results: Research findings show the mean results of feasibility and implementation of all 6 areas of international standards MCI have feasibility in three hospitals in Sabzevar in 20 sections (H1=105.01±10.468), (H1=196.31±4.662), (H2=104.26±9.099), (H2=195.33±3.778) (H3=106.48±11.545) and (H3=197.57±4.943), respectively. Conclusion: The results showed that the mean feasibility and implementation of all six areas of MCI international standards is practical in three hospitals in Sabzevar in 20 wards. Also, 50% of users in clinical departments, physicians, and nurses agreed to appropriateness of the hospital information and communication systems for doing their duties.

      PubDate: Sat, 26 Mar 2016 08:37:54 GMT
       
  • Conceptual Model of Clinical Governance Information System for Statistical
           Indicators by Using UML in Two Sample Hospitals

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Fatemeh Rangraz Jeddi, Mehrdad Farzandipoor, Masoud Arabfard, and Azam Haj Mohammad Hosseini.
      Objective: The purpose of this study was investigating situation and presenting a conceptual model for clinical governance information system by using UML in two sample hospitals. Background: However, use of information is one of the fundamental components of clinical governance; but unfortunately, it does not pay much attention to information management. Material and Methods: A cross sectional study was conducted in October 2012- May 2013. Data were gathered through questionnaires and interviews in two sample hospitals. Face and content validity of the questionnaire has been confirmed by experts. Data were collected from a pilot hospital and reforms were carried out and Final questionnaire was prepared. Data were analyzed by descriptive statistics and SPSS 16 software. Results: With the scenario derived from questionnaires, UML diagrams are presented by using Rational Rose 7 software. The results showed that 32.14 percent Indicators of the hospitals were calculated. Database was not designed and 100 percent of the hospital’s clinical governance was required to create a database. Conclusion: Clinical governance unit of hospitals to perform its mission, do not have access to all the needed indicators. Defining of Processes and drawing of models and creating of database are essential for designing of information systems.

      PubDate: Sat, 26 Mar 2016 08:36:39 GMT
       
  • Determination of Minimum Data Set (MSD) in Echocardiography Reporting
           

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Zahra Mahmoudvand, Mehran Kamkar, Leila Shahmoradi, Ahmadreza Farzaneh Nejad.
      Background: Determination of minimum data set (MDS) in echocardiography reports is necessary for documentation and putting information in a standard way, and leads to the enhancement of electrocardiographic studies through having access to precise and perfect reports and also to the development of a standard database for electrocardiographic reports. Aim: to determine the minimum data set of echocardiography reporting system to exchange with Iran’s electronic health record (EHR) system. Methods: First, a list of minimum data set was prepared after reviewing texts and studying cardiac patients’ records. Then, to determine the content validity of the prepared MDS, the expert views of 10 cardiologists and 10 health information management (HIM) specialists were obtained; to estimate the reliability of the set, test-retest method was employed. Finally, the data were analyzed using SPSS software. Results: The highest degree of consensus was found for the following MDSs: patient’s name and family name (5), accepting doctor’s name and family name, familial death records due to cardiac disorders, the image identification code, mitral valve, aortic valve, tricuspid valve, pulmonary valve, left ventricle, hole, atrium valve, Doppler examination of ventricular and atrial movement models and diagnoses with an average of. Conclusions: To prepare a model of echocardiography reporting system to exchange with EHR system, creation a standard data set is the vital point. Therefore, based on the research findings, the minimum reporting system data to exchange with Iran’s electronic health record system include information on entity, management, medical record, carried-out acts, and the main content of the echocardiography report, which the planners of reporting system should consider.

      PubDate: Sat, 26 Mar 2016 08:35:12 GMT
       
  • Design and Development of a Clinical Risk Management Tool Using Radio
           Frequency Identification (RFID)

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Faramarz Pourasghar, Jafar Sadegh Tabrizi, Khadijeh Yarifard.
      Background: Patient safety is one of the most important elements of quality of healthcare. It means preventing any harm to the patients during medical care process. Objective: This paper introduces a cost-effective tool in which the Radio Frequency Identification (RFID) technology is used to identify medical errors in hospital. Methods: The proposed clinical error management system (CEMS) is consisted of a reader device, a transfer/receiver device, a database and managing software. The reader device works using radio waves and is wireless. The reader sends and receives data to/from the database via the transfer/receiver device which is connected to the computer via USB port. The database contains data about patients’ medication orders. Results: The CEMS has the ability to identify the clinical errors before they occur and then warns the care-giver with voice and visual messages to prevent the error. This device reduces the errors and thus improves the patient safety. Conclusion: A new tool including software and hardware was developed in this study. Application of this tool in clinical settings can help the nurses prevent medical errors. It can also be a useful tool for clinical risk management. Using this device can improve the patient safety to a considerable extent and thus improve the quality of healthcare.

      PubDate: Sat, 26 Mar 2016 08:33:03 GMT
       
  • The Diagnostic Value of MRI in Brucella Spondylitis With Comparison to
           Clinical and Laboratory Findings

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Ali Baradaran Bagheri, Koorosh Ahmadi, Niaz Mohamad Jafari Chokan, Bita Abbasi, Reza Akhavan, Ehsan Bolvardi, Somayeh Soroureddin.
      Background: Brucellosis is an endemic zoonotic disease, especially in the Middle East and Mediterranean regions and can involve many organs and tissue. Osteoarticular involvement is the most common complication. Spondylitis is its most prevalent clinical form in adults, and there may be difficult in diagnosis and treatment. In present study, we aimed to assess these diagnostic value of MRI, in patients with spondylitis due to brucella, comparing with clinical and laboratory findings. Method: Patients with low back pain who were admitted to Sheikhol-raees MRI center were included in this study. None of these patients had any documented infectious disease. Diagnosis of brucellosis was made, based on MRI findings, which would be approved by serology. After confirmation with serology, the group with positive serology were compared with the negative group, in sex, age, MRI findings level of vertebral involvements, signal intensity in T1 weighted and T2 weighted. Results: Among 53 patients with diagnosis of brucella spondylitis, 33 underwent serology study, 20 were positive and 13 were negative and the others consider out of study. From these 20, 3 had tuberculosis spondylitis, whose mean age was 56 and the 67% of them were male. Mean age in the positive brucella spondylitis were 46 and 67% of them were male. In negative group mean age was 55, and of whom 57% were male. There was no statistically significant difference in MRI findings such as changes in signal intensity, disk space narrowing, Intracanalicular mass, Abscess formation. Level of invlovment in vertebrae. Conclusion: The results of this study shows that although MRI is Modality of choice in diagnosis of spondylitis, it is not enough specific to diagnosis the reasons of spondylitis.

      PubDate: Sat, 26 Mar 2016 08:31:21 GMT
       
  • The Significance of MRI Evaluation of the Uterine Junctional Zone in the
           Early Diagnosis of Adenomyosis

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Amela Sofic, Azra Husic-Selimovic, Aladin Carovac, Elma Jahic, Velda Smailbegovic, Jana Kupusovic.
      Goal: The aim of the study is to define the MRI appearance of disorder in the Junctional zone (JZ) in women with adenomyosis compared to those without it, given the importance of the JZ in the regulation of various reproductive events. Materials and methods: This was a prospective, comparative and open study. Patients with adenomyosis have been sorted in target group, n = 82, while the control group consisted of patients without adenomyosis, n = 82. All patients, from both groups have undergone a magnetic resonance imaging of the pelvis. Using a software tool for measurement, the thickness of the JZ was measured in T2w sag sequences in all patients from both groups (target and control) n = 164. Patients in the target group type adenomyosis were assessed and categorized either as: diffuse, focal, or Adenomyoma and the results were compared. The presence of endometriosis and myomas in both groups was evaluated and its coexistence with adenomyosis was analyzed as well. Results: Of the 82 patients in the target group, 81.7% of the patients had diffuse adenomyosis, while 18.3% had focal type with statistically significant difference (p

      PubDate: Sat, 26 Mar 2016 08:29:48 GMT
       
  • Advantages of Combined PET-CT in Mediastinal Staging in Patients with
           Non-small Cell Lung Carcinoma

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Nermina Beslic, Amera Sadija, Renata Milardovic, Timur Ceric, Sejla Ceric, Adnan Beganovic, Spomenka Kristic, Semra Cavaljuga.
      Introduction: Precise mediastinal lymph node staging in patients with non-small cell lung carcinoma (NSCLC) provides important prognostic information and it is obligatory in treatment strategy planning. 18Fluoro-deoxy-glucose (18F-FDG) positron emission tomography - computerized tomography (PET-CT) based on detection of metabolic activity showed superiority in preoperative staging of lung carcinoma. Materials and Methods: Total number of 26 patients diagnosed with NSCLC were included in this retrospective, cross-sectional study. Status of mediastinal lymph nodes was assessed in all patients comparing contrast enhanced CT and 18F-FDG PET-CT findings. Discussion: We found in our study that 50% of patients had different N stage on contrast enhanced CT comparing to 18F-FDG PET-CT findings. Among the total number of patients which had different nodal status on PET-CT comparing to CT alone, we found in our study that 54% of patients had change in further therapy protocol after PET-CT change of nodal stage. Conclusion: Combined PET-CT which offers advantages of both modalities is excellent method for nodal (N) staging, so it is recommended in initial staging in patients with NSCLC. PET-CT used preopratively for mediastinal nodal staging has significant impact on further therapy planning and also has an consequential impact on health system savings.

      PubDate: Sat, 26 Mar 2016 08:27:42 GMT
       
  • Evaluation of Diagnostic Methods in the Differentiation of Heart Murmurs
           in Children

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Zijo Begic, Senad Pesto, Senka Mesihovic Dinarevic, Edin Begic, Amra Dobraca, Izet Masic.
      Introduction: The most common clinical sign in pediatric cardiology is a heart murmur (organic and inorganic). Organic are sign of heart disease, while inorganic (basically divided into accidental and functional) murmurs occur on anatomically healthy heart.. Aim: To determine the justification of the application of the methods of cardiac treatment. Patients and methods: Study included 116 children aged from 1 to 15 years, who were referred due to cardiac treatment to Pediatric Clinic, of Sarajevo University Clinical Center. Results: The first group consisted of children with innocent heart murmur, 97 (53 males). The second group consisted of patients with organic murmur, 19 (13 males). The average age of the first group was 7.69 (1.01–15.01) years old, and of the second group 3.15 (1.01- 8.06) years old, and there is a significant difference between these two groups (p

      PubDate: Sat, 26 Mar 2016 08:25:37 GMT
       
  • Use of Databases for Early Recognition of Risk of Diabetic Complication by
           Analysis of Liver Enzymes in Type 2 Diabetes Mellitus

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Maja Malenica, Besim Prnjavorac, Adlija Causevic, Tanja Dujic, Tamer Bego, Sabina Semiz.
      Introduction: Because of increasing prevalence of T2MD worldwide, it’s very important to recognize risk factors for diabetic complications, as soon as possible. Symptoms of complications appear a few or many years after tissue damage. So, it’s imperative to establish surveillance of diabetics with laboratory and other diagnostic procedures for early recognition of diabetic complications. Follow up of clinical curs of diabetes, by using databases of patients, provide possibility for permanent analysis of important laboratory parameters and any changes could be registered. Although an emerging evidence suggests a strong association of ALT (alanine aminotransferase) and γGT (gamma glutamyl transferase) activity with type 2 diabetes mellitus (T2DM), only a limited number of studies have analyzed the association of AST (aspartate aminotransferase), ALT, γGT, and ALP (alkaline phosphatase) activities in controlled T2DM. Material and Methods: Gender differences are of special interest in trying to follow diabetes progression and development of its complications. Here the activities of ALT, AST, γGT, ALP were analyzed as well as levels of glycosylated hemoglobin (HbA1c) and fasting plasma glucose (FPG) in 40 T2DM patients and 40 age-matched healthy subjects. Blood samples were collected from all participants in regular 3-months intervals up to 6 months period. Standard IFCC enzyme protocols were used to determine enzyme activities. Results and discussion: In first measured interval, significantly higher activities of ALT (p= 0,050) and glucose levels (p=0,045) were shown in male. A significant correlation was shown between ALT and AST activity with FPG and HbA1c levels in first and third measured interval. ALT activity was much higher in the group of patients with poor glycemia control. Average levels of activities of enzymes stay nearly in normal limits, but changes of enzymes activities should be recognized as soon as possible, earlier than tissue changes and diabetic complications become irreversible.

      PubDate: Sat, 26 Mar 2016 08:23:45 GMT
       
  • Review of the Journal Acta Informatica Medica During Eight Year Period:
           2008-2015

    • Abstract: 2016-03-28T04-23-16Z
      Source: Acta Informatica Medica
      Izet Masic, Edin Begic, Lejla Zunic.
      Introduction: Acta Informatica Medica is official journal of the Academy for Medical Sciences of Bosnia and Herzegovina (from 2014 Acta Inform Med is published bimonthly). Aim: To evaluate journal “Acta Informatica Medica” in 2015 and compare findings to previous years. Material and methods: The study has retrospective and descriptive character, and included the period 2008-2015 (included 36 issues of journal). Results: A total of 83 (average 13,8 articles per journal) articles were published in Acta Informatica Medica during 2015. Analyzing the type of articles, original articles are present in majority during 2015 (68,6%) (by analyzing last eight years, 310 (67,3%) were original). During 2015, 27,7% of articles were related to the applied of Health informatics in field of clinical medicine, 63,8% preclinical medicine and 8,5% to public health. Collaboration rate in 2015 was 0,84. Most often the time required for decision on acceptance of article in 2015 is between 50 and 60 days. Articles came from 16 countries. According to scimagojr.com for 2014, Acta Informatica Medica has SCImago Journal Rank 0,166, while Cites / Doc. (2years) parameter (widely used as impact index) is 0,70. According to GoogleScholar, h5 index is 11 and h5 median is 19. We analyzed the Acta Informatica Medica by “Publish or Perish” software - H index was 14, g index was 19 and e-index was 10.39. Conclusion: Year after year the highest number of original articles are published. Although the period of revision of articles is acceptable, the period up to two months is certainly not long, the goal is to reduce this period. Although the magazine in mentioned field found its place, although it is indexed in numerous bases, including: PubMed, PubMed Central, SCOPUS, EMBASE, EBSCO, etc. The main goal for next year is that the magazine becomes part of the Web of Science. Imperative is further internationalization of the magazine.

      PubDate: Sat, 26 Mar 2016 08:21:19 GMT
       
  • The Most Influential Scientist in the Development of Medical informatics
           (10): Marsden S. Blois

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Izet Masic.


      PubDate: Tue, 02 Feb 2016 05:45:28 GMT
       
  • Foramen Magnum Meningioma: a Case Report and Review of Literature

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Pavao Jurinovic, Ana Repic Bulicic, Marino Marcic, Nikolina Ivica Mise, Marina Titlic, Enra Suljic.
      Introduction: Meningiomas are slow-growing benign tumors that arise at any location where arachnoid cells reside. Although meningiomas account for a sizable proportion of all primary intracranial neoplasms (14.3–19%), only 1.8 to 3.2% arise at the foramen magnum. Their indolent development at the craniocervical junction makes clinical diagnosis complex and often leads to a long interval between onset of symptoms and diagnosis. Case report: We report a case of a 79-year-old male patient, presented with ataxia and sense of threatening fainting during verticalization. Magnetic resonance imaging revealed the presence of meningioma in the right side of craniospinal junction.

      PubDate: Tue, 02 Feb 2016 05:36:15 GMT
       
  • Successful Evaluation of Biphasic T-wave of Wellens Syndrome in the
           Emergency Department

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Ali Attila Aydin, Kemal Türker Ulutas, Cemile Aydin, Murtaza Kaya, Umut Akar, Tayfun Ture.
      Introduction: Wellens Syndrome (WS) is a condition characterized by typical changes in ECG, which are biphasic T-wave inversions (less common) or symmetric and deeply inverted T waves (including 75%) in lead V2–V3 chest derivations. WS is considered important because it has not only diagnostic value but also prognostic value. Case report: A 52-year-old male patient without cardiovascular disease or risk factors was admitted to the emergency department (ED) suffering with chest pain and syncope, just after having been involved in a discussion at work. Chest pain was radiating to the left arm and was not precipitated by exertion. Shortness of breath was not accompanied by angina. The patient underwent cardiac catheterization at Department of Cardiology. Stents were positioned in both LADA and a severe lesion in the left main coronary artery. The patient was discharged two days following catheterization, due to no chest pain and hemodynamic instability during the hospitalization. The patient has approved the inform consent for to be used for this case report.

      PubDate: Tue, 02 Feb 2016 05:34:00 GMT
       
  • Laparoscopic Management of Adhesive Small Bowel Obstruction

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Ferid Konjic, Enes Idrizovic, Ismar Hasukic, Alen Jahic.
      Introduction: Adhesions are the reason for bowel obstruction in 80% of the cases. In well selected patients the adhesive ileus laparoscopic treatment has multiple advantages which include the shorter hospitalization period, earlier food taking, and less postoperative morbidity rate. Case report: Here we have a patient in the age of 35 hospitalized at the clinic due to occlusive symptoms. Two years before an opened appendectomy had been performed on him. He underwent the treatment of exploration laparoscopy and laparoscopic adhesiolysis. Dilated small bowel loops connected with the anterior abdominal wall in the ileocecal region by adhesions were found intraoperatively and then resected harmonically with scalpel. One strangulation around which a small bowel loop was wrapped around was found and dissected. Postoperative course was normal.

      PubDate: Tue, 02 Feb 2016 05:32:16 GMT
       
  • Social and Psychological Effects of the Internet Use

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Marianna Diomidous, Kostis Chardalias, Adrianna Magita, Panagiotis Koutonias, Paraskevi Panagiotopoulou, John Mantas.
      Background and Aims: Over the past two decades there was an upsurge of the use of Internet in human life. With this continuous development, Internet users are able to communicate with any part of the globe, to shop online, to use it as a mean of education, to work remotely and to conduct financial transactions. Unfortunately, this rapid development of the Internet has a detrimental impact in our life, which leads to various phenomena such as cyber bullying, cyber porn, cyber suicide, Internet addiction, social isolation, cyber racism etc. The main purpose of this paper is to record and analyze all these social and psychological effects that appears to users due to the extensive use of the Internet. Materials and Methods: This review study was a thorough search of bibliography data conducted through Internet and library research studies. Key words were extracted from search engines and data bases including Google, Yahoo, Scholar Google, PubMed. Findings: The findings of this study showed that the Internet offers a quick access to information and facilitates communication however; it is quite dangerous, especially for young users. For this reason, users should be aware of it and face critically any information that is handed from the website

      PubDate: Tue, 02 Feb 2016 04:32:55 GMT
       
  • ELISA Test for Analyzing of Incidence of Type 1 Diabetes Autoantibodies
           (GAD and IA2) in Children and Adolescents

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Marina Delic-Sarac, Selma Mutevelic, Jasenko Karamehic, Salih Saracevic, Djemo Subasic, Tomislav Jukic, Jozo Coric, Ognjen Ridjic, Mirsad Panjeta, Lejla Zunic.
      Introduction: Anti GAD (antibodies on glutamic acid decarboxylase) and anti-IA2 antibodies (against tyrosine phosphatase ), today, have their place and importance in diagnosis and prognosis of Type 1 diabetes. Huge number of patients with diabetes mellitus type 1 have these antibodies. Insulin antibodies are of critical importance in diagnosis of diabetes mellitus type 1 for pediatric population. Materials and methods: During 2014, the samples of 80 patients from Clinical Center University Sarajevo (CCUS) Pediatrics clinic’s, Endocrinology department were analyzed on anti-GAD and IA2 antibodies. The samples of serums of all patients were analyzed with ELISA tests using Anti GAD ELISA (IgG) kites from EUROIMMUN company. These are quantitative in vitro tests for human antibodies against decarboxylase of glutamine acid (GAD) and IA2, in serum or EDTA plasm. Results: During the period of one year, in CCUS’s Organizational unit, Institute for Clinical Immunology, 80 samples of patients with anti GAD and IA2 antibodies were analyzed. Out of total number of samples, 41 were male patients, or 51% and 39 female, or 49%. The youngest patient was born in 2012, and the oldest in 1993. Age average was represented by the patients born in 2001. Share of positive results for IA2 antibodies and GAD antibodies was 37% for IA2 antibodies, and 63% for GAD antibodies. Discussion: During an autoimmune – mediated Diabetes mellitus type 1 leads to T-cell mediated destruction of beta cells of pancreatic islets, reduced production of insulin and glucose metabolism. Studies have shown that these bodies are the most intense single marker for identifying persons with increased risk for diabetes development.

      PubDate: Tue, 02 Feb 2016 04:29:37 GMT
       
  • Comparative Investigation of Health Literacy Level of Cardiovascular
           Patients Hospitalized in Private and Educational Hospitals of Kerman City,
           Iran

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Sajedeh Malekzadeh, Mohammad Azami, Moghadameh Mirzaei, Fatemeh Motamedi.
      Introduction: literacy involves a complex set of abilities to understand and use symbolic systems of a culture for personal development and social development in a diverse set of skills required as an adult to exercise behavior are considered in society. Objectives: The aim of this study was to evaluate Comparative investigation of health literacy level of cardiovascular patients hospitalized in private and public educational hospitals of Kerman city. Methods: This study used survey methods, analytical and cross-sectional manner. Data was collected through questionnaires distributed among 200 patients of cardiovascular-hospitalization took place in the city of Kerman. To analyze the data in the description of the mean, standard deviation and frequency distribution tables and the level of analysis to determine the relationship between gender and marital status of health literacy test or nonparametric test Mann-Whitney T-Test and, for the relationship between group employment and residence, a one-way analysis of variance or Kruskal-Wallis test, to evaluate the relationship between age and income, Pearson and Spearman correlation to investigate the relationship between level of education and health literacy of SPPS software version 21 was used. Results: The results showed that 10% of patients at educational hospitals in Kerman adequate health literacy, and 48% of patients in private hospitals had adequate health literacy. As a result, there is a significant difference of health literacy between the two types of hospital (p-value

      PubDate: Tue, 02 Feb 2016 04:25:53 GMT
       
  • Factors Affecting Successful Implementation of Hospital Information
           Systems

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Mehrdad Farzandipur, Fatemeh Rangraz jeddi, Esmaeil Azimi.
      Background: Today, the use of information systems in health environments, like any other fields,is necessary and organizational managers are convinced to use these systems. However, managers’ satisfaction is not the only factor in successfully implementing these systems and failed information technology projects (IT) are reported despite the consent of the directors. Therefore, this study aims to determine the factors affecting the successful implementation of a hospital information system. Methods: The study was carried out as a descriptive method in 20 clinical hospitals that the hospital information system (HIS) was conducted in them. The clinical and paraclinical users of mentioned hospitals are the study group. 400 people were chosen as samples in scientific method and the data was collected using a questionnaire consisted of three main human, managerial and organizational, and technological factors, by questionnaire and interview. Then the data was scored in Likert scale (score of 1 to 5) and were analyzed using the SPSS software. Results: About 75 percent of the population were female, with average work experience of 10 years and the mean age was 30 years. The human factors affecting the success of hospital information system implementation achieved the mean score of 3.5, both organizational and managerial factors 2.9 and technological factors the mean of 3. Conclusion: Human factors including computer skills, perceiving usefulness and perceiving the ease of a hospital information system use are more effective on the acceptance and successful implementation of hospital information systems; then the technological factors play a greater role. It is recommended that for the successful implementation of hospital information systems, most of these factors to be considered

      PubDate: Tue, 02 Feb 2016 04:24:29 GMT
       
  • Health Information Security in Hospitals: the Application of Security
           Safeguards

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Esmaeil Mehraeen, Haleh Ayatollahi, Maryam Ahmadi.
      Introduction: A hospital information system has potentials to improve the accessibility of clinical information and the quality of health care. However, the use of this system has resulted in new challenges, such as concerns over health information security. This paper aims to assess the status of information security in terms of administrative, technical and physical safeguards in the university hospitals. Methods: This was a survey study in which the participants were information technology (IT) managers (n=36) who worked in the hospitals affiliated to the top ranked medical universities (university A and university B). Data were collected using a questionnaire. The content validity of the questionnaire was examined by the experts and the reliability of the questionnaire was determined using Cronbach’s coefficient alpha (α=0.75). Results: The results showed that the administrative safeguards were arranged at a medium level. In terms of the technical safeguards and the physical safeguards, the IT managers rated them at a strong level. Conclusion: According to the results, among three types of security safeguards, the administrative safeguards were assessed at the medium level. To improve it, developing security policies, implementing access control models and training users are recommended.

      PubDate: Tue, 02 Feb 2016 04:23:06 GMT
       
  • Evaluating Usability of Radiology Information Systems in Hospitals of
           Tabriz University of Medical Sciences

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Peyman Rezaei-Hachesu, Esmaeil Pesianian, Mohsen Mohammadian.
      Introduction and purpose: Radiology information system (RIS) in order to reduce workload and improve the quality of services must be well-designed. Heuristic evaluation is one of the methods that understand usability problems with the least time, cost and resources. The aim of present study is to evaluate the usability of RISs in hospitals. Research Method: This is a cross-sectional descriptive study (2015) that uses heuristic evaluation method to evaluate the usability of RIS used in 3 hospitals of Tabriz city. The data are collected using a standard checklist based on 13 principles of Nielsen Heuristic evaluation method. Usability of RISs was investigated based on the number of components observed from Nielsen principles and problems of usability based on the number of non-observed components as well as non-existent or unrecognizable components. Results: by evaluation of RISs in each of the hospitals 1, 2 and 3, total numbers of observed components were obtained as 173, 202 and 196, respectively. It was concluded that the usability of RISs in the studied population, on average and with observing 190 components of the 291 components related to the 13 principles of Nielsen is 65.41 %. Furthermore, problems of usability were obtained as 26.35%. Discussion and Conclusion: The established and visible nature of some components such as response time of application, visual feedbacks, colors, view and design and arrangement of software objects cause more attention to these components as principal components in designing UI software. Also, incorrect analysis before system design leads to a lack of attention to secondary needs like Help software and security issues.

      PubDate: Tue, 02 Feb 2016 04:19:41 GMT
       
  • Comparing Smoothing Techniques for Fitting the Nonlinear Effect of
           Covariate in Cox Models

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Daem Roshani, Ebrahim Ghaderi.
      Background and Objective: Cox model is a popular model in survival analysis, which assumes linearity of the covariate on the log hazard function, While continuous covariates can affect the hazard through more complicated nonlinear functional forms and therefore, Cox models with continuous covariates are prone to misspecification due to not fitting the correct functional form for continuous covariates. In this study, a smooth nonlinear covariate effect would be approximated by different spline functions. Material and Methods: We applied three flexible nonparametric smoothing techniques for nonlinear covariate effect in the Cox models: penalized splines, restricted cubic splines and natural splines. Akaike information criterion (AIC) and degrees of freedom were used to smoothing parameter selection in penalized splines model. The ability of nonparametric methods was evaluated to recover the true functional form of linear, quadratic and nonlinear functions, using different simulated sample sizes. Data analysis was carried out using R 2.11.0 software and significant levels were considered 0.05. Results: Based on AIC, the penalized spline method had consistently lower mean square error compared to others to selection of smoothed parameter. The same result was obtained with real data. Conclusion: Penalized spline smoothing method, with AIC to smoothing parameter selection, was more accurate in evaluate of relation between covariate and log hazard function than other methods.

      PubDate: Tue, 02 Feb 2016 04:17:05 GMT
       
  • Developing a Fuzzy Expert System to Predict the Risk of Neonatal Death

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Reza Safdari, Maliheh Kadivar, Mostafa Langarizadeh, Ahmadreaza Farzaneh Nejad, Farzaneh Kermani.
      Introduction: This study aims at developing a fuzzy expert system to predict the possibility of neonatal death. Materials and Methods: A questionnaire was given to Iranian neonatologists and the more important factors were identified based on their answers. Then, a computing model was designed considering the fuzziness of variables having the highest neonatal mortality risk. The inference engine used was Mamdani’s method and the output was the risk of neonatal death given as a percentage. To validate the designed system, neonates’ medical records real data at a Tehran hospital were used. MATLAB software was applied to build the model, and user interface was developed by C# programming in Visual Studio platform as bilingual (English and Farsi user interface). Results: According to the results, the accuracy, sensitivity, and specificity of the model were 90%, 83% and 97%, respectively. Conclusion: The designed fuzzy expert system for neonatal death prediction showed good accuracy as well as proper specificity, and could be utilized in general hospitals as a clinical decision support tool.

      PubDate: Tue, 02 Feb 2016 04:15:08 GMT
       
  • The Diagnostic Value of Skin Disease Diagnosis Expert System

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Fatemeh Rangraz Jeddi, Masoud Arabfard, Zahra Arbkermany, Hamidreza Gilasi.
      Background: Evaluation is a necessary measure to ensure the effectiveness and efficiency of all systems, including expert systems. The aim of this study was to determine the diagnostic value of expert system for diagnosis of complex skin diseases. Methods: A case-control study was conducted in 2015 to determine the diagnostic value of an expert system. The study population included patients who were referred to Razi Specialized Hospital, affiliated to Tehran University of Medical Sciences. The control group was selected from patients without the selected skin diseases. Data collection tool was a checklist of clinical signs of diseases including pemphigus vulgaris, lichen planus, basal cell carcinoma, melanoma, and scabies. The sample size formula estimated 400 patients with skin diseases selected by experts and 200 patients without the selected skin diseases. Patient selection was undertaken with randomized stratified sampling and their sign and symptoms were logged into the system. Physician’s diagnosis was determined as the gold standard and was compared with the diagnosis of expert system by SPSS software version 16 and STATA. Kappa statistics, indicators of sensitivity, specificity, accuracy and confidence intervals were calculated for each disease. An accuracy of 90% was considered appropriate. Results: Comparing the results of expert system and physician’s diagnosis at the evaluation stage showed an accuracy of 97.1%, sensitivity of 97.5% and specificity of 96.5% The Kappa test indicated a high agreement of 93.6%. Conclusion: The expert system can diagnose complex skin diseases. Development of such systems is recommended to identify all skin diseases.

      PubDate: Tue, 02 Feb 2016 04:13:13 GMT
       
  • Defining the Modalities of Intravenous Contrast Application During the
           Diagnostics of Hepatic Metastases with Computerized Tomography

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Arben Kutllovci, Halit Ymeri, Drita Zogaj, Skender Kutllovci, Dukagjin Zogaj.
      Introduction: The liver is the biggest human abdominal parenchymal organ; it weights approximately 1500 grams and is located in the right hypochondrium, under the diaphragm. Liver is able to perform multiple functions also by means of the rich dual vascularization: hepatic arterial system and the portal vein system, between which exists a short circuit (shunt) and free mixture inside the sinusoid, whilst the two flows drain in the same vein system. The discovery of CT and its application in practice fundamentally changes the importance of diagnostic methods for hepatobiliary lesions. Patients and methods: During a 4-year period, 984 patients suspected with liver or biliary tract disease were explored with CT. 117 of these patients were analyzed with liver metastases. Examinations of the liver was performed in dorsal decubitus and in absolute apnea with spiral movement of the table and in denominations of 1and 5 mm. Siemens MSCT 64 and 6 tier apparatuses enable short scanning time with almost immediate reconstruction, which offers all the necessary elements required for carrying out certain protocols. Results: The average density of metastatic lesions is about 20 HU smaller than normal liver parenchyma. Metastasis with necrosis are more hypodense (30-50 HU smaller than normal liver parenchyma), whilst necrotic metastases with smaller dimensions are almost isodense with normal parenchyma. However, metastases with diameter between 4 to 6 cm are completely isodense and will remain so even after the application of I.V. contrast. The average more frequent size according to most authors, as well as according to our material (148 patients or 90%) was 2-3 cm in transversal diameter.

      PubDate: Tue, 02 Feb 2016 03:59:04 GMT
       
  • Interventional Radiologists: a Necessary Evaluation of Technical,
           Protective and Technological Operation

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Sayed Ali Rahimi, Maryam Pourkaveh.
      Background and purpose: To present the results of occupational radiation doses investigated through a Hospitals of Mazandaran Medical Science Universities in north of Iran. Radiology unit has an important role in diagnosis of many disorders with providing suitable and high quality pictures. A good picture was provided using correct technical criteria and suitable circumstance of patient. Finally, operation and knowledge of radiology personnel directly has a primary role in determining quality of radiography. Materials and Methods: This study was done in order to determine personnel operation in the units of hospitals radiologist related to University of Mazandaran Medical Science. Data collection tools are made of a researcher check list that was used after obtaining suitable letter and validity indexes. All of the 73 personnel of radiology unit related to Mazandaran Medical Science were studied. 35 operations (in technical, protective and technological fields) of any personnel, in three distinct shifts were observed and recorded. All of them were tested regarding these three fields with a total of 40 questions. Results: The total scores received from personnel in technical part in the morning, evening and night shift were 66.4, 53.9 and 60.2 percent respectively. Received scores from personnel in the protective fields were 68.1, 59.5 and 60.2 percent. Moreover, received scores from personnel in the technological operation fields were 47.8, 39.95 and 43.65 percent respectively. Comparison of these three scores in technical, protective and technological operation fields showed a meaningful difference (p

      PubDate: Tue, 02 Feb 2016 03:57:33 GMT
       
  • Maximum Time of the Effect of Antileukotriene - Zileuton in Treatment of
           Patients with Bronchial Asthma

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Naim Morina, Gëzim Boçari, Ali Iljazi, Kadir Hyseini, Gunay Halac.
      Objective: Maximum time of the effect of antileukotriene substances - Zileuton in the treatment of patients with bronchial asthma and increased bronchial reactivity and of the salbutamol as agonist of the beta2 adrenergic receptor studied in this work. Methods: Parameters of the lung function are determined with Body plethysmography. Raw and ITGV were registered and specific resistance (SRaw) was calculated. Zileuton (Zyflo, tbl.. 600 mg), producer Cornerstone Therapeutics, USA was used in the research. Results: Results of this research, in patients with bronchial asthma, indicate that antileukotriene substances–Zileuton administered in a dose of 600 mg first day (oral route of administration 4 x 1 tbl..) has not caused significant decrease of the specific resistance of the airways (SRaw) (p value 0.1> Alpha 0.05), whereas Zileuton administered two days in a row, in a dose of 600 mg (4 x 1 tbl.. a day), has caused significant decrease of the specific resistance of the airways (SRaw) (P value 0.03 < Alpha 0.05). Effect of the control with salbutamol (beta2-adrenergic receptor agonist) is efficient in the removal of the increased bronchomotor tone, causing significant decrease of the resistance (Raw), respectively of the specific resistance (SRaw), (p value 0.05 = Alpha 0.05). Conclusion: Formation of leukotrienes depends on the lypoxygenation of the arachidonic acid by 5-lypoxygenase. Zileuton is an active and powerful inhibitor of the activity of 5- lypoxygenase and as such inhibits generation of its products. Consequently, besides inhibition of cys-LTs’, zileuton also inhibits the formation of leukotriene B4 (LTB4), which is a powerful chemotactic of other eicosanoids too, which depend on the synthesis of lekotriene A4 (LTA4). This suggests that the effect of antileukotrienes (Zileuton) is not immediate after oral administration, but the powerful effect of the Zileuton seen only after two days of inhibition of cys-LTs’, and inhibition of leukotriene B4 (LTB4) and A4 (LTA4).

      PubDate: Tue, 02 Feb 2016 03:55:58 GMT
       
  • Hepato - Cephalic Index as a Predictor of Intrauterine Growth Restriction

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Ramadan Dacaj, Sebija Izetbegovic, Goran Stojkanovic, Curr Gjocaj.
      Aim: The aims of this study were to compare ultrasound fetoplacental parameters and to calculate Hepato-Cephalic Index (HCI) as a new predictor of IUGR. Methods and material: A clinical prospective study was conducted and included 120 pregnant women divided in two groups: non IUGR group included healthy pregnant women (n=60) and IUGR group included pregnant women with preeclampsia and IUGR (n=60). Outcome measures were following ultrasound fetoplacental parameters in fetuses with IUGR and non IUGR: Fetal Liver Length (FLL), Femur Length (FL), Biparietal Diameter (BPD), Placental Maturation by Grannum, Amniotic Fluid Index (AFI) and Hepato-Cephalic Index (HCI). Sonography was carried out by probe 3.5 Mhz type MINDRAY DC 7. Results: The mean of maternal age was 30.0±6.1 years in women with preeclampsia and IUGR and 28.1±5.1 years in healthy pregnant women, p> 0.05. There was a statistically significant difference in values of: FLL (p < 0.001), FL (p = 0.004), BPD (p < 0.001), AFI (p < 0.001), HCI (p < 0.001) between IUGR and non IUGR groups. The most of women with preeclampsia and IUGR had grade III of placental maturation (48.3%). There is a significant association between the placental maturation and the diagnosis, p < 0.001. There was a statistically significant difference in body mass of newborns between IUGR and non IUGR groups, p < 0.001. Conclusion: In a fetus with IUGR in preeclampsia there is a reduction in FLL, FL, BPD, AFI and HCI and there is a early maturation of the placenta. By measurement of fetoplacental ultrasonic parameters of liver, pregnant women will experience prediction of risk pregnancy (preeclampsia with IUGR) due to hypoxia.

      PubDate: Tue, 02 Feb 2016 03:17:56 GMT
       
  • Scientometric Analysis of the Journals of the Academy of Medical Sciences
           in Bosnia and Herzegovina

    • Abstract: 2016-02-10T04-32-18Z
      Source: Acta Informatica Medica
      Izet Masic, Edin Begic, Lejla Zunic.
      Introduction: Currently in Bosnia and Herzegovina there are 25 journals in the field of biomedicine, 6 of them are indexed in Medline/PubMed base (Medical Archives, Materia Socio-Medica, Acta Informatica Medica, Acta Medica Academica, Bosnian Journal of Basic Medical Sciences (BJBMS) and Medical Glasnik), and one (BJBMS) is indexed in Science Citation Index Expanded (SCIE)/Web of Science base. Aim: The aim of this study was to show the scope of work of the journals that were published by Academy of Medical Sciences of Bosnia and Herzegovina - Medical Archives, Materia Socio-Medica and Acta Informatica Medica. Material and Methods: The research presents a meta-analysis of three journals, or their issues, during the calendar year 2015 (retrospective and descriptive character). Results: During 2015 calendar year a total of 286 articles were published (in Medical Archives 104 (36.3%), in Materia Socio-Medica 99 (34.6%), and in Acta Informatica Medica 83 (29%)). Original articles are present in the highest number in all three journals (in Medical Archives 80.7%, in Materia Socio Medica 77.7%, and in Acta Informatica Medica 68.6%). In Medical Archives, 90.3% of the articles were related to the field of clinical medicine. In Materia Socio-Medica, the domain of clinical medicine and public health was the most represented. Preclinical areas are most frequent in Acta Informatica Medica. The period of 50-60 days for a decision on the admission of article is most common in all three journals, with trend of shortening of that period. Articles came from 19 countries, mostly from Bosnia and Herzegovina, then from Iran, Kosovo, Saudi Arabia and Greece. Conclusion: In Medical Archives original articles in the field of clinical medicine (usually internal and surgical disciplines) are most often present, and that is the case in last four years. The number of articles in Materia Socio-Medica and Acta Informatica Medica is growing from year to year. In Materia Socio-Medica there is a trend of growth of articles in the field of public health, while the most common articles in Acta Informatica Medica are about medical informatics.

      PubDate: Tue, 02 Feb 2016 03:03:32 GMT
       
 
 
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