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Journal Cover Journal of Kerman University of Medical Sciences
  [SJR: 0.116]   [H-I: 3]   [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1023-9510 - ISSN (Online) 2008-2843
   Published by Kerman University of Medical Sciences Homepage  [6 journals]
  • The Effect of Prolonged Exposure to Low-Frequency Electromagnetic Fields
           on the Cholinergic System in the Small Intestine of Male Rat

    • Authors: Sayyed Esmaeil Khoshnam, Seyedeh Marzieh Jafari, Amin allah Bahaoddini, Maryam Owjfard
      Abstract: Background & Aims: In the recent years, increasing rate of using electronic devices which generate electromagnetic fields, has caused researchers, attention to the effects of electromagnetic fields on human health. The aim of this study is to investigate the effect of prolonged exposure to extremely low frequency electromagnetic fields (ELF) on the Cholinergic system in the small intestine of rat. Methods: A total of 21 Adult male rats were divided into three groups: experimental group which were exposed to ELF (50Hz, 1mT) for 75 days, the sham-operated group, which were kept in similar conditions, but with Off solenoid; and the control group, which were kept in normal conditions. The isolated strips of the colon were inserted into organ bath and were linked to power lab A to D system force transducer and their mechanical activity were recorded in response to different doses of acetyl choline. Data were analyzed using one way ANOVA test. Results: The relaxation of ileum in response to the acetyl choline (10-6 M) at different times and after deducting the basic tension showed a significant decrease (p≤0.05) in the experimental group as compared to the sham and control groups. While, the relaxation of ileum in response to the other dozes of acetyl choline (10-5 M) in the experimental group showed no significant difference as compared to sham and control groups. Conclusion: It can be concluded that prolonged exposure to extremely low-frequency electromagnetic fields might cause decreasing of the cholinergic receptors sensitivity.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Distally Based Sural Artery Flap: A Workhorse to Cover the Soft Tissue
           Defects of Distal Leg, Ankle and Foot

    • Authors: Mahmood Reza Ashab-Yamin, Amir Reza Sadeghifar, Alireza Saiid, Maryam Gharehgozli
      Abstract: Background & Aims: Distal leg, ankle and foot injuries are relatively common; and because of lack of soft tissue and poor blood supply in these areas, one of the common problems in these patients is soft tissue necrosis. Exposed orthopedic implants can be used as open reduction internal fixator (ORIF) in these regions. Methods: During 2013-2014, 14 patients (11 men and 3 women) with a mean age of 30 years were enrolled the study in the Department of Plastic and Reconstructive Surgery, Shafa Hospital, Kerman, Iran. All the patients were referred from the Department of Orthopedic Surgery because of exposed orthopedic implants. The minimum and maximum size of the defects was 3 × 5 and 11 × 15 cm, respectively. 7 defects were in distal leg, 3 in foot, 2 in ankle and 2 in distal leg and ankle together. After measuring the defect, sural flap based on sural artery and nerve was prepared and transferred with a rotation of 180 degrees to the defect site over the exposed orthopedic implants, before the separation. Results: In all 14 patients, the healing was complete. In 2 cases, we had to remove the prostheses because of infection and in 3 cases, partial necrosis was seen; and in 4 cases, a hypertrophic scar was seen in donor site and a neurosensorial deficit was seen in the sural nerve sensory areas. But in all of them, the sural flap was successful and there was no need to replace this flap to another one. Conclusion: Due to the good clinical results, sural flap can be a viable alternative to cover the exposed prostheses of distal leg, ankle and foot.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Frequency of Seropositivity for anti-Coxiella Burnetii (Phase II) among
           Veterinary Staff in Southern Khorasan, Iran, in 2014

    • Authors: Mohammad Khalili, Mohammad Reza Aflatoonian, Mohammad Rahanjam, Mehdi Golchin, Hamid Sharifi, Behnaz Aflatoonian
      Abstract: Background and Aims: Q fever is a public health concern in many countries especially in recent years. There are a few studies in Iran. This study aimed to determine the seropositivity for Q fever among veterinary staff in southern Khorasan, Iran. Methods: 92 serum samples were obtained from all veterinary employees and tested using an indirect enzyme-linked immunosorbent assay (ELISA). The data including age, sex, education, having contact with the secretion of cattle abortion, and keeping animal in house were analyzed using descriptive statistics and confidence interval of 95%, and chi-square and logistic regression tests. Results: Totally, 54.3% of serum samples were positive (57.1% in men and 40.0% in women). The results of logistic regression showed that in people who had contact with the secretions of cattle abortion the odds ratio was 2.3 times more than those who had not contact with livestock abortion. Other factors did not show any significant relationship. Conclusion: These data indicate high seropositivity in veterinary staff of southern Khorasan. Thus, training this high-risk group of people looks to be necessary to prevent the disease. In addition, complementary studies in other parts of Iran are suggested to clarify the epidemiological aspects of Q fever in this group.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • The Efficacy, Relapse and Failure in the Treatment of Anthroponotic
           Cutaneous Leishmaniosis with Intralesional Glucantime Along with
           Cryotherapy

    • Authors: Mehran Karvar, Iraj Sharifi, Mohammad Hossein Daie Parizi, Zahra Baziar, Noushin Pouryazdanpanah, Amireh Heshmatkhah
      Abstract: Background & Aims: It is more than half of a century that the drug of choice for treatment of cutaneous leishmaniosis (CL) has been pentavalent antimony compounds such as meglumine antimoniate (Glucantime). The aim of the present study was to evaluate the efficacy, relapse and treatment failure of intralesional Glucantime plus cryotherapy in the treatment of anthroponotic CL (ACL). Methods: The sample of this analytic cross-sectional study included 547 lesions belonged to 322 patients who had referred to Dadbin Health Clinic afilliated to Kerman University of Medical Sciences, from March 2013 to March 2014. They received the local treatment with intralesional Glucantime once a week coupled with cryotherapy using liquid nitrogen once every two weeks and for at most three months. The effectiveness was defined as the proportion of cured lesions to the treatment- received lesions. Results: Of 547 lesions, 399 lesions (73%) were cured, 86 lesions (15.7%) were partially cured, and 62 lesions (11.3%) had treatment failure. From 399 lesions which were cured completely, 21 (5.3%) lesions had developed with relapse. The rates of treatment failure and relapse were not associated with the sex of patients. While, these two variables showed significant relationships with lesions’ location and the age group of patients (p<0.05). Conclusion: This study showed that the efficacy of the intralesional injection of Glucantime combined with cryotherapy was 73%. Since the relapse and treatment failure were mostly observed in the age group of 0-9 year old and in lesions on face and hands, more attention to these lesions is necessary.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Prevalence of blaCTX-M1, blaCTX-M14 and blaCTX-M15 Genes among Escherichia
           Coli Isolated from Urinary Tract Infections in Outpatients, Kermanshah
           City, Iran

    • Authors: Alisha Akya, Mehrdad Khodadoost
      Abstract: Background and Aims: The rate of urinary tract infection caused by the extended-spectrum-β-lactamase-(ESBL) producing Escherichia coli (E. coli) is increasing worldwide. This study aimed to assess the frequency of blaCTX-M genes in the E. coli isolated from urinary tract infection (UTI) in outpatients. Methods: 240 E. coli bacteria were isolated from the outpatients’ urine samples in the Kermanshah city, Iran. The susceptibility of isolates to 10 selected antibiotics was tested using the disc diffusion method. Then, the phenotype of the extended-spectrum-β-lactamase-producing isolates was determined using the combined disc method. Finally, blaCTX-M1, blaCTX-M14 and blaCTX-M15 genes were determined via polymerase chain reaction (PCR) method. Results: Of 240 isolates, 199 isolates (82.9%) showed resistance to ampicillin, but 100% were sensitive to imipenem. 96 isolates (40.0%) were resistant to three or more antibiotic groups. Moreover, 67 isolates (27.9%) were extended-spectrum-β-lactamase producer and 61 (91.0%), 58 (86.6%) and 21 (31.3%) isolates contained blaCTX-M1, blaCTX-M14 and blaCTX-M15 genes, respectively. Conclusion: Resistance to various β-lactam antibiotics, in particular the third generation of cephalosporins, among community-acquired E. coli isolates is a serious concern in Kermanshah city. Production of extended-spectrum β-lactamase, specially the dissemination of blaCTX-M genes among community-acquired E. coli isolates, is a big threat for using expected-spectrum cephalosporins. Given the presence of extended-spectrum-β-lactamase genes in the high proportion of the urinary tract infection isolates, suitable antibiotics should be chosen according to the antibiotic susceptibility tests.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • The Relationship of Neurotic Perfectionism and Obsessive Thoughts with
           Body Image Dissatisfaction among Female Diet Applicants

    • Authors: Farshid Khosropour, Zahra Sharifpour, Gholamreza Ebrahiminejad
      Abstract: Background & Aims: Body image represents the attitude of the individual toward himself/herself, along with the feelings and thoughts that can change individuals’ behavior in various conditions and in the positive or negative direction. In neurotic perfectionism, extreme tendency to perfectionism, obsessive thoughts, impulses, or unwanted images can be observed that can damage women’s perception toward visual beauty and body image, and physical attraction. Dieting is a method by which body image can be improved. Methods: This correlational study was conducted on 109 patients referred to a specialized nutrition and diet therapy clinic. The participants were selected using systematic sampling. In order to collect data, the Multidimensional Body-Self Relations Questionnaire (MBSRQ), Frost Multidimensional Perfectionism Scale (FMPS), and Obsessive Beliefs Questionnaire-44 (OBQ-44) were used. Data were analyzed using the SPSS 18 software. Results: A significant relationship was observed between body image, neurotic perfectionism, and obsessive thoughts. About 26% of the variances in the criterion variable (body image dissatisfaction) could be explained by the predictor variables of neurotic perfectionism and obsessive thoughts. Further evaluation of the two predictor variables showed that only neurotic perfectionism had a significant relationship with body image dissatisfaction. Conclusion: Due to the importance of nutrition in women's health, a careful evaluation of and consultation for the patients seem necessary before providing them with a diet plan. The evaluation of perfectionism and obsessive thoughts in patients can predict the success of the diet programs.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Comparison of Perceived Stress on the Basis of Controlling Self-efficacy
           and Self-esteem among Athlete and Non-athlete Staff

    • Authors: Mojtaba Amanollahnejad-Kalkhoran, Seyed Mohammad Kazem Vaezmousavi, Kiumars Beshlideh
      Abstract: Background and Aims: Present study aimed to compare the individual psychological antecedents of perceived stress (self-efficacy and self-esteem) among the athlete and non-athlete staff in an industrial company. Methods: Statistical society was all persons employed in the company including managers, supervisors, experts and workers; 192 athletes and 208 non-athletes were selected randomly. Data was collected using three questionnaires including perceived stress, overall self-efficacy, and self-esteem. Results: Although findings of ANOVA test showed that the condition of perceived stress in athlete employees was better than non-athletes, after controlling the impacts of self-efficacy and self-esteem, the results of ANCOVA test revealed that the difference of perceived stress between these two groups was not significant. Conclusion: The findings of this research suggest that the exercise can lead to gaining perceived strss to an optimized level (positive stress) mainly by improving valuable beliefs and promoting self-efficacy in individuals. The study extends the models of perceived stress literature and offers managerial, educational and practical suggestions for practitioners working about staff or employees exercise.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Evaluation of the Relationship between the Dimensions of the Nurses’
           Quality of Working Life and Social Desirability in Fars Province, Iran

    • Authors: Narges Roustaei, Jamshid Jamali, Najaf Zare, Seyyed Mohammad Taghi Ayatollahi, Saeed Hosseini Teshnizi
      Abstract: Background & Aimes: The nurses’ quality of working life (QWL) influences the quality of health services provided by them and can be affected by several factors. In this study, we assessed the effect of social desirability on nurses’ QWL in Fars province, southern Iran. Methods: In this cross-sectional descriptive and analytic study in 2014, 331 nurses were selected from 7 cities of Fars province using multistage cluster sampling method. Data collection was carried out using Marlowe-Crowne Social Desirability Scale and Work-Related Quality of Life Scale of University of Portsmouth. Multivariate regression model was applied to estimate the simultaneous effects of factors. Results: 22.1% of studied nurces were men and 63.9% were married. The nurses’ mean age and work-experience period were 31.26 ± 6.52 and 6.07 + 5.72 years, respectively. Variables such as age, marital status, working experience, employment type, administrative responsibilities and shift work had significant relationship with some of the dimensions , and the social desirability variable was effective on all the dimensions of the QWL (P < 0.05). 22.8% of nurses had low, 70.9% had moderate and 6.3% had high social desirability. Conclusion: Regarding the relationship between the social desirability and all dimensions the QWL, it is necessary for health system managers to provide appropriate strategies, such as in-service training, to increase the social desirability for nursing. Increasing social desirability, support of nurses in their workplace and creating a safe environment for them would improve nurses’ QWL.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Expandable DNA Repeat and Human Hereditary Disorders

    • Authors: Shahin Ramazi, Ali Fasihi, Maryam Godarziyan, Morteza Hashemzadeh-Chaleshtori
      Abstract: Background & Aims: Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA, including fragile X syndrome, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. One the most frequently occurring types of mutation is trinucleotide repeat expansion. The present study was conducted with the aim of investigating the cause and molecular mechanisms of repeat expansions DNA and their pathogenic mechanisms in diverse classes of genetic diseases. Methods: Scientific databases were searched using the keywords expandable DNA repeat fragile X, myotonic dystrophy, Huntington’s disease, and Friedreich’s ataxia. After primary screening, articles which were related to the studies topic were further considered and analyzed. Results: DNA repeats seem to be predisposed to such expansion due to their unusual structural features, which disrupt the cellular replication, repair, and recombination processes. The majority of these debilitating diseases are caused by repeat expansions in the noncoding regions of their resident genes. The pathogenic mechanism underling these disorders include loss of function in protein and gain of function in protein or ribonucleic acid (RNA). Conclusion: Although diseases caused by trinucleotide repeat expansion vary in their phenotypes, they are somewhat similar in their pathogenic mechanism and medical findings. It is likely that progress made in this field will be beneficial to patients who have other neurological diseases.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • Observation of Nocardia Asteroides Complex in a Patient with Corneal
           Ulceration: The First Case Report from Iran

    • Authors: Seyedeh Zeinab Seyyed-Yousefi, Mehdi Fatahi-Bafghi, Seyyed Saeed Eshraghi, Bagher Hoseini, Shadi Habibnia, Masoumeh Rasouli-Nasab, Parvin Heidarieh
      Abstract: Background & Aims: Nocardia asteroides is gram-positive, partially acid-fast, aerobic actinomycetes which cause a wide range of skin infections, and pulmonary, cerebral, and ocular infection. Case Presentation: A 60-year-old man with diabetes presented with ocular ulcers in 2015. Through the medical records evaluation, physical examination, and biochemical evaluation of the patient, Nocardia asteroides complex was identified as the cause of infection. The patient was treated with amikacin and ciprofloxacin, and recovery was obtained and the patient was placed on the waiting list for corneal transplantation. Conclusion: Diagnosis of keratitis caused by Nocardia asteroides is difficult and it may be misdiagnosed due similarities with keratitis caused by nontuberculous mycobacteria (NTM). Therefore, suitable diagnosis methods and early diagnosis of ocular nocardiosis are necessary. In the present study, Nocardia asteroides complex was isolated from a corneal ulceration.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
  • The Effect of Endurance Activity on Expression of sox6 Gene of Left
           Ventricle in Male Wistar Rat

    • Authors: Mohammad Fathi, Saeid Abroun
      Abstract: Background & Aims: The expression of myocardium gene can be affected by endurance activity; besides, sox6 transcription factor influences its formation. This study aimed to investigate the effect of 14 weeks of endurance activity on expression of sox6 gene of left ventricle in male Wistar rats. Methods: Forteen rats were housed under the controlled conditions and after adjusting with endurance program, were randomly assigned into two groups of control and experimental. For the experimental group, an endurance program (14 weeks, 6 days/week, 60 minutes/day, and velocity of 30 m/minutes) on motorized treadmill was performed. Then, the rats were anesthetized and sacrificed 48 hours after the end of the last session and the left ventricle was removed. Real-time polymerase chain reaction (RT-PCR) method was used to determine the expression levels of sox6 gene in the left ventricle. The collected data were evaluated using t-test. Results: The ratio of left ventricle weight (LVW) to the body surface area (BSA) was significantly (P=0.010) higher in experimental group (0.168 ± 0.008 g/m2) compared to the control group (0.153±0.006g/m2). The ratio of heart weight (HW) to the body surface area was significantly (P = 0.002) higher in experimental group (0.270 ± 0.014) compared to the control group (0.240 ± 0.019), too. In addition, the mean expression value of sox6 gene of left ventricle was significantly higher in experimental group (P = 0.001), too. Conclusion: It seems that physical activity improves heart functional indices (the ratio of left ventricle and heart weight to body surface area), especial in left ventricle, via increasing the expression of sox6 gene.
      PubDate: 2016-04-08
      Issue No: Vol. 23 (2016)
       
 
 
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