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Journal Cover Ultrasonic Imaging
  [SJR: 0.61]   [H-I: 38]   [2 followers]  Follow
   Hybrid Journal Hybrid journal (It can contain Open Access articles)
   ISSN (Print) 0161-7346 - ISSN (Online) 1096-0910
   Published by Sage Publications Homepage  [852 journals]
  • Can Elastography Predict Growth of Incidental Thyroid Nodules' A Pilot
           Two-Year Follow-Up Study
    • Authors: Krejbjerg, A; Pedersen, I. B, Laurberg, P.
      Pages: 303 - 313
      Abstract: The objective of this study was to examine the ultrasonography (US) and ultrasound elastography (USE) features of thyroid incidentalomas in a population exposed to iodine deficiency and to investigate whether baseline elasticity scores (ES) predicted changes in thyroid nodule US characteristics. We conducted a two-year follow-up pilot study of thyroid incidentalomas by US and USE. One sonographer performed the US and USE examination on the same apparatus at baseline and at follow-up. We evaluated 83 incidental thyroid nodules detected in a population study. The follow-up period saw no change in median thyroid nodule diameter (p = 0.18) or in the prevalence of thyroid nodule US characteristics (hypoechoic: p = 0.05; solid nodule: p = 1.00; microcalcifications: p = 0.55). Individual changes in thyroid nodule diameter (>20%) were seen in 23% (11% had decreased, and 12% had increased in diameter). Changes in ES were frequently observed; 37% changed from ES A + B to ES C + D, and 27% changed from ES C + D to ES A + B. In a multivariate logistic regression model, we found no association between baseline ES and individual changes in nodule size. In an area with mild iodine deficiency and a high prevalence of thyroid nodules, thyroid USE performed on thyroid incidentalomas did not predict individual changes in thyroid nodule size.
      PubDate: 2016-08-09T04:06:18-07:00
      DOI: 10.1177/0161734615604626
      Issue No: Vol. 38, No. 5 (2016)
  • A Review of Intravascular Ultrasound-based Multimodal Intravascular
           Imaging: The Synergistic Approach to Characterizing Vulnerable Plaques
    • Authors: Ma, T; Zhou, B, Hsiai, T. K, Shung, K. K.
      Pages: 314 - 331
      Abstract: Catheter-based intravascular imaging modalities are being developed to visualize pathologies in coronary arteries, such as high-risk vulnerable atherosclerotic plaques known as thin-cap fibroatheroma, to guide therapeutic strategy at preventing heart attacks. Mounting evidences have shown three distinctive histopathological features—the presence of a thin fibrous cap, a lipid-rich necrotic core, and numerous infiltrating macrophages—are key markers of increased vulnerability in atherosclerotic plaques. To visualize these changes, the majority of catheter-based imaging modalities used intravascular ultrasound (IVUS) as the technical foundation and integrated emerging intravascular imaging techniques to enhance the characterization of vulnerable plaques. However, no current imaging technology is the unequivocal "gold standard" for the diagnosis of vulnerable atherosclerotic plaques. Each intravascular imaging technology possesses its own unique features that yield valuable information although encumbered by inherent limitations not seen in other modalities. In this context, the aim of this review is to discuss current scientific innovations, technical challenges, and prospective strategies in the development of IVUS-based multi-modality intravascular imaging systems aimed at assessing atherosclerotic plaque vulnerability.
      PubDate: 2016-08-09T04:06:18-07:00
      DOI: 10.1177/0161734615604829
      Issue No: Vol. 38, No. 5 (2016)
  • Indentation Measurements to Validate Dynamic Elasticity Imaging Methods
    • Authors: Altahhan, K. N; Wang, Y, Sobh, N, Insana, M. F.
      Pages: 332 - 345
      Abstract: We describe macro-indentation techniques for estimating the elastic modulus of soft hydrogels. Our study describes (a) conditions under which quasi-static indentation can validate dynamic shear-wave imaging estimates and (b) how each of these techniques uniquely biases modulus estimates as they couple to the sample geometry. Harmonic shear waves between 25 and 400 Hz were imaged using ultrasonic Doppler and optical coherence tomography methods to estimate shear dispersion. From the shear-wave speed of sound, average elastic moduli of homogeneous samples were estimated. These results are compared directly with macroscopic indentation measurements measured two ways. One set of measurements applied Hertzian theory to the loading phase of the force–displacement curves using samples treated to minimize surface adhesion forces. A second set of measurements applied Johnson–Kendall–Roberts theory to the unloading phase of the force–displacement curve when surface adhesions were significant. All measurements were made using gelatin hydrogel samples of different sizes and concentrations. Agreement within 5% among elastic modulus estimates was achieved for a range of experimental conditions. Consequently, a simple quasi-static indentation measurement using a common gel can provide elastic modulus measurements that help validate dynamic shear-wave imaging estimates.
      PubDate: 2016-08-09T04:06:18-07:00
      DOI: 10.1177/0161734615605046
      Issue No: Vol. 38, No. 5 (2016)
  • Experimental Validation of ARFI Surveillance of Subcutaneous Hemorrhage
           (ASSH) Using Calibrated Infusions in a Tissue-Mimicking Model and Dogs
    • Authors: Geist, R. E; DuBois, C. H, Nichols, T. C, Caughey, M. C, Merricks, E. P, Raymer, R, Gallippi, C. M.
      Pages: 346 - 358
      Abstract: Acoustic radiation force impulse (ARFI) Surveillance of Subcutaneous Hemorrhage (ASSH) has been previously demonstrated to differentiate bleeding phenotype and responses to therapy in dogs and humans, but to date, the method has lacked experimental validation. This work explores experimental validation of ASSH in a poroelastic tissue-mimic and in vivo in dogs. The experimental design exploits calibrated flow rates and infusion durations of evaporated milk in tofu or heparinized autologous blood in dogs. The validation approach enables controlled comparisons of ASSH-derived bleeding rate (BR) and time to hemostasis (TTH) metrics. In tissue-mimicking experiments, halving the calibrated flow rate yielded ASSH-derived BRs that decreased by 44% to 48%. Furthermore, for calibrated flow durations of 5.0 minutes and 7.0 minutes, average ASSH-derived TTH was 5.2 minutes and 7.0 minutes, respectively, with ASSH predicting the correct TTH in 78% of trials. In dogs undergoing calibrated autologous blood infusion, ASSH measured a 3-minute increase in TTH, corresponding to the same increase in the calibrated flow duration. For a measured 5% decrease in autologous infusion flow rate, ASSH detected a 7% decrease in BR. These tissue-mimicking and in vivo preclinical experimental validation studies suggest the ASSH BR and TTH measures reflect bleeding dynamics.
      PubDate: 2016-08-09T04:06:18-07:00
      DOI: 10.1177/0161734615617940
      Issue No: Vol. 38, No. 5 (2016)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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