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The Medical Letter
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   Full-text available via subscription Subscription journal
     ISSN (Print) 0025-732X - ISSN (Online) 1523-2859
     Published by The Medical Letter, Inc Homepage  [1 journal]   [SJR: 0.161]   [H-I: 15]
  • Drugs for Inflammatory Bowel Disease - The Medical Letter
    • Authors: admin
      Abstract: August 4, 2014 - Aminosalicylates are effective for induction and maintenance of remission in mild to moderate ulcerative colitis. They are not recommended for treatment of Crohn's disease.
  • In Brief: Esomeprazole Strontium - The Medical Letter
    • Authors: admin
      Abstract: July 21, 2014 - The FDA has approved the proton pump inhibitor (PPI) esomeprazole strontium for use in adults for the same indications as esomeprazole magnesium (Nexium): treatment of gastroesophageal reflux disease (GERD), prevention of NSAID-induced gastric ulcers, eradication of Helicobacter pylori, and treatment of pathological hypersecretory conditions. It was first marketed in December 2013 as a branded drug (Esomeprazole Strontium) and a month later as a generic drug.Strontium is incorporated into bone. It is not recommended for use in children or during pregnancy...
  • In Brief: Low-Dose Indomethacin (Tivorbex) for Pain - The Medical Letter
    • Authors: admin
      Abstract: July 21, 2014 - The same pharmaceutical company (Iroko) that recently marketed low-dose diclofenac (Zorvolex) for treatment of mild to moderate acute pain1 has now received approval from the FDA to market a lowdose oral formulation of indomethacin (Tivorbex) for the same indication. Tivorbex is available in 20- and 40-mg capsules; conventional immediate-release indomethacin capsules contain 25 mg and 50 mg of the drug.The rationale for this new product is the same as the one offered for Zorvolex: the drug is formulated as submicron...
  • Extended-Release Oxycodone and Acetaminophen (Xartemis XR) - The Medical
    • Authors: admin
      Abstract: July 21, 2014 - The FDA has approved a fixed-dose extended-release formulation of oxycodone and acetaminophen (Xartemis XR – Mallinckrodt) for oral treatment of acute pain severe enough to require an opioid. Oxycodone is available in the US as a single entity in oral immediate-release (Oxecta, and others) and extendedrelease (OxyContin) formulations. Immediate-release oxycodone is also available in combination with aspirin (Percodan, and others), acetaminophen (Percocet, and others), or ibuprofen (see Table 1).
  • Oral Propranolol (Hemangeol) for Infantile Hemangioma - The Medical Letter
    • Authors: admin
      Abstract: July 21, 2014 - The FDA has approved an oral solution of the nonselective beta-adrenergic blocker propranolol (Hemangeol – Pierre Fabre) for treatment of proliferating infantile hemangiomas.
  • Ceritinib (Zykadia) for Non-Small Cell Lung Cancer - The Medical Letter
    • Authors: admin
      Abstract: July 21, 2014 - Ceritinib (Zykadia – Novartis), an oral tyrosine kinase inhibitor, has received accelerated approval from the FDA for treatment of patients with anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) who have progressed on or are intolerant to crizotinib (Xalkori). It is the second tyrosine kinase inhibitor to be approved for ALK-positive metastatic NSCLC; crizotinib was the first. Translocations of the ALK gene are found in about 5% of lung cancers; they occur predominantly in nonsmokers with adenocarcinoma.
  • A Responsive Neurostimulator Device (RNS System) for Epilepsy - The
           Medical Letter
    • Authors: admin
      Abstract: July 21, 2014 - The FDA has approved the use of a responsive neurostimulator device (RNS System – NeuroPace) for adjunctive treatment of adults with partial-onset seizures that are not controlled with ≥2 antiepileptic drugs and who have frequent and disabling seizures and no more than 2 epileptogenic foci.
  • Adult Immunization - Treatment Guidelines
    • Authors: admin
      Abstract: June 1, 2014 - Vaccines recommended for adults residing in the US are reviewed here. Vaccines for travel have been reviewed separately.
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