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Journal Cover   JRSM Cardiovascular Disease
  [1 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2048-0040 - ISSN (Online) 2048-0040
   Published by Sage Publications Homepage  [819 journals]
  • Microbubbles shunting via a patent foramen ovale impair endothelial
           function

    • Authors: Fok, H; Jiang, B, Chowienczyk, P, Clapp, B.
      Pages: 2048004015 - 2048004015
      Abstract: Objectives Exposure to intravascular microbubbles after diving and during medical procedures alters endothelial function. The aim of this study was to investigate whether a patent foramen ovale altered forearm endothelial function by facilitating microbubbles transfer. Design Patients attended on two separate visits, at least seven days apart receiving agitated saline or no active intervention in random order. On both days, flow-mediated dilatation of the brachial artery was measured using vascular ultrasound. On the intervention visit, agitated saline was injected and the passage of microbubbles into the arterial circulation was confirmed by echocardiography. Serial flow-mediated dilatation measurements were made after agitated saline and at the same time points after no intervention. Setting St Thomas’ Hospital in London. Participants Patients with a patent foramen ovale (PFO+n = 14, 9 male, mean ± SD age 42.2 ± 10.5 years) and patients without a patent foramen ovale (PFO– n = 10, 7 male, mean ± SD age 49.4 ± 18.4 years) were recruited. Main outcome measures Change in brachial artery flow-mediated dilatation. Results In patent foramen ovale + patients, flow-mediated dilatation did not change significantly on the control day but after agitated saline reduced by 2.3 ± 0.3%, 20 minutes after bubble injection (P < 0.005 vs. corresponding change in flow-mediated dilatation during control study). There was no significant change in flow-mediated dilatation for patent foramen ovale– patients at either visit. Conclusion These results suggest that the presence of a patent foramen ovale facilitated impairment of endothelial function acutely by the transfer of microbubbles into the arterial circulation. As a patent foramen ovale is a common condition, this may be relevant to microbubbles exposure in medical procedures and in decompression illness.
      PubDate: 2015-08-26T23:44:14-07:00
      DOI: 10.1177/2048004015601564
      Issue No: Vol. 4, No. 0 (2015)
       
  • Longstanding insulin dependent diabetics may not require insulin after the
           introduction of GLP-1 analogues

    • Authors: Raja, U. Y; Eastaugh, A. E, Younas, M. S, Hanif, W.
      Pages: 2048004015 - 2048004015
      Abstract: Glucagon like peptide (GLP-1) analogues are a relatively novel medication developed primarily for the treatment of type 2 diabetes since 2005. Although GLP-1 analogues have been shown to be more effective in the first few years of diagnosis in type 2 diabetes, we report a case of a patient with longstanding insulin-dependent diabetes started on a GLP-1 analogue, liraglutide, who now has controlled blood sugars without the need of insulin.
      PubDate: 2015-03-12T04:57:56-07:00
      DOI: 10.1177/2048004015576008
      Issue No: Vol. 4, No. 0 (2015)
       
 
 
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