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Journal Cover JRSM Cardiovascular Disease
  [1 followers]  Follow
  This is an Open Access Journal Open Access journal
   ISSN (Print) 2048-0040 - ISSN (Online) 2048-0040
   Published by Sage Publications Homepage  [835 journals]
  • Expression of the PlA2 allele of glycoprotein IIIa and its impact on
           platelet function

    • Authors: Floyd, C. N; Ferro, A, Warner, T. D.
      Pages: 2048004015 - 2048004015
      Abstract: Background The platelet fibrinogen receptor represents the final common pathway of platelet activation, and is formed from two glycoprotein (GP) subunits (GPIIb/IIIa). Carriage of the mutant PlA2 allele of GPIIIa has been shown to confer an increased risk of cardiovascular events, but published studies have disagreed as to the mechanism for this association. Objectives To assess whether carriage of the PlA2 allele conforms to Mendelian patterns of expression and to identify whether carriage of the mutant allele modulates platelet function. Methods Expression of the PlA2 allele was assessed in both healthy subjects (n = 25) and patients with known coronary artery disease (n = 90) through the development and validation of a liquid chromatography, tandem mass spectrometry (LC-MS/MS) assay. Platelet function was assessed in the patient cohort in response to multiple agonists, and these data were analysed in the context of the proteomic data. Results Expression of the wild-type PlA1 allele and mutant PlA2 alleles was readily quantifiable and conformed to Mendelian patterns in both healthy and patient cohorts. Patients who were homozygous for the mutant PlA2 allele had an increased aggregatory response to adenosine diphosphate, collagen, adrenaline, ristocetin, thrombin receptor-activating peptide 6 and U46619, when assessed using agonist-concentration response curves. Conclusions These findings support the hypothesis that carriage of the mutant PlA2 allele mediates an increased risk of cardiovascular events through the modulation of platelet reactivity.
      PubDate: 2015-11-04T22:54:49-08:00
      DOI: 10.1177/2048004015610252
      Issue No: Vol. 4, No. 0 (2015)
  • Microbubbles shunting via a patent foramen ovale impair endothelial

    • Authors: Fok, H; Jiang, B, Chowienczyk, P, Clapp, B.
      Pages: 2048004015 - 2048004015
      Abstract: Objectives Exposure to intravascular microbubbles after diving and during medical procedures alters endothelial function. The aim of this study was to investigate whether a patent foramen ovale altered forearm endothelial function by facilitating microbubbles transfer. Design Patients attended on two separate visits, at least seven days apart receiving agitated saline or no active intervention in random order. On both days, flow-mediated dilatation of the brachial artery was measured using vascular ultrasound. On the intervention visit, agitated saline was injected and the passage of microbubbles into the arterial circulation was confirmed by echocardiography. Serial flow-mediated dilatation measurements were made after agitated saline and at the same time points after no intervention. Setting St Thomas’ Hospital in London. Participants Patients with a patent foramen ovale (PFO+n = 14, 9 male, mean ± SD age 42.2 ± 10.5 years) and patients without a patent foramen ovale (PFO– n = 10, 7 male, mean ± SD age 49.4 ± 18.4 years) were recruited. Main outcome measures Change in brachial artery flow-mediated dilatation. Results In patent foramen ovale + patients, flow-mediated dilatation did not change significantly on the control day but after agitated saline reduced by 2.3 ± 0.3%, 20 minutes after bubble injection (P < 0.005 vs. corresponding change in flow-mediated dilatation during control study). There was no significant change in flow-mediated dilatation for patent foramen ovale– patients at either visit. Conclusion These results suggest that the presence of a patent foramen ovale facilitated impairment of endothelial function acutely by the transfer of microbubbles into the arterial circulation. As a patent foramen ovale is a common condition, this may be relevant to microbubbles exposure in medical procedures and in decompression illness.
      PubDate: 2015-08-26T23:44:14-07:00
      DOI: 10.1177/2048004015601564
      Issue No: Vol. 4, No. 0 (2015)
  • Longstanding insulin dependent diabetics may not require insulin after the
           introduction of GLP-1 analogues

    • Authors: Raja, U. Y; Eastaugh, A. E, Younas, M. S, Hanif, W.
      Pages: 2048004015 - 2048004015
      Abstract: Glucagon like peptide (GLP-1) analogues are a relatively novel medication developed primarily for the treatment of type 2 diabetes since 2005. Although GLP-1 analogues have been shown to be more effective in the first few years of diagnosis in type 2 diabetes, we report a case of a patient with longstanding insulin-dependent diabetes started on a GLP-1 analogue, liraglutide, who now has controlled blood sugars without the need of insulin.
      PubDate: 2015-03-12T04:57:56-07:00
      DOI: 10.1177/2048004015576008
      Issue No: Vol. 4, No. 0 (2015)
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