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Journal Cover Functional Neurology
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     ISSN (Print) 0393-5264
     Published by CIC Edizioni Internazionali Homepage  [1 journal]   [SJR: 0.423]   [H-I: 25]
  • Elman Neural Network for the Early Identification of Cognitive Impairment
           in Alzheimer's Disease
    • Abstract: AbstractEarly detection of dementia can be useful to delay progression of the disease and to raise awareness of the condition. Alterations in temporal and spatial EEG markers have been found in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Herein, we propose an ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Magnetic Stimulation of the Cerebellum. Moving towards the Clinic
    • Abstract: Dear Reader,Transcranial magnetic stimulation (TMS) is a brain stimulation technique that is attracting growing interest due to its potential for intervention in various neurological and psychiatric conditions. The TMS principle is simple: by generating a controlled magnetic field at high ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • How to Assess Abstract Conceptual Knowledge: Construction, Standardization
           and Validation of a New Battery of Semantic Memory Tests
    • Abstract: SummaryThe neuropsychological investigation of semantic memory has mainly focused on concrete concepts, while abstract concepts have been relatively neglected. We describe a new battery for assessing abstract concepts in brain-damaged patients. The battery includes three different tests: an ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Arm Weight Support Training Improves Functional Motor Outcome and Movement
           Smoothness after Stroke
    • Abstract: SummaryThe aim of this study was to compare the effectiveness in acute stroke patients of a rehabilitation program performed with or without an arm weight support device. Twenty-eight acute, first-ever unilateral stroke patients were enrolled in a single-blind, randomized controlled trial.Clinical ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Hemifacial Hyperhidrosis Associated with Ipsilateral/contralateral
           Cervical Disc Herniation Myelopathy. Functional Considerations on How
           Compression Pattern Determines the Laterality
    • Abstract: SummarySweating is an important mechanism for ensuring constant thermoregulation, but hyperhidrosis may be disturbing. We present five cases of hemifacial hyperhidrosis as a compensatory response to an/hypohidrosis caused by cervical disc herniation. All the patients complained of hemifacial ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Liver Cirrhosis in Patients Newly Diagnosed with Neurological Phenotype of
           Wilson's Disease
    • Abstract: SummaryWilson's disease (WD) can manifest itself in different clinical forms, the neurological and hepatic ones being the most common. It is suggested that neurological signs and psychiatric symptoms develop secondary to liver involvement. The aim of this study was to characterize the liver disease ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Cerebellar Theta Burst Stimulation in Stroke Patients with Ataxia
    • Abstract: SummaryEvidence for effective improvement of the symptoms of cerebellar stroke is still limited. Here, we investigated the effects of repetitive transcranial magnetic stimulation (rTMS) applied over the injured cerebellar hemisphere in six patients with posterior circulation stroke. We applied a ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • An Observational Retrospective/horizontal Study to Compare Oxygen-Ozone
           Therapy And/or Global Postural Re-Education in Complicated Chronic Low
           Back Pain
    • Abstract: SummaryAcute low back pain (LBP) is the fifth most common reason for physician visits and about nine out of ten adults experience back pain at some point in their life. In a large number of patients LBP is associated with disc herniation (DH).Recently, oxygen-ozone (0203) therapy has been used ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Epilepsy and Phenylketonuria: A Case Description and EEG-fMRI Findings
    • Abstract: SummaryPhenylketonuria (PKU) is characterized by phenylalanine accumulation due to phenylalanine hydroxylase deficiency. Up to 50% of PKU patients experience seizures. We evaluated an adult PKU patient who suffered from absences and primarily generalized tonicclonic seizures, associated with ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Diabetes Mellitus May Induce Cardiovascular Disease by Decreasing
           Neuroplasticity
    • Abstract: SummaryNeuroplasticity has been defined "the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections". The nervous system monitors and coordinates internal organ function. Thus neuroplasticity may be associated with the ... (Publication: Functional Neurology)
      PubDate: Wed, 01 Jan 2014 00:00:00 -050
       
  • Diet Transiently Improves Migraine in Two Twin Sisters: Possible Role of
           Ketogenesis'
    • Abstract: SummaryThe ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss.We report the case of a ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Requests for Electromyography in Rome: A Critical Evaluation
    • Abstract: SummaryTo date, there exist no data reporting the level of suitability of requests for electromyography examinations (EMGs) in Rome. The records of 1,220 consecutive patients (age: 57.6±15.0 years; 400 M, 820 F) in two neurophysiology laboratories were collected and analyzed. In total, 1,317 EMGs ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Use of Health and Social Care Services in a Cohort of Italian Dementia
           Patients
    • Abstract: SummaryThe aim of this study, conducted in the Region of Lazio, Italy, in 2008-2010, was to describe the use, over a one-year period, of health and social care services in a cohort of 712 patients with a diagnosis of dementia. These patients had never previously used such services.We evaluated the ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • A Cross-Sectional Study Investigating Clinical Predictors and Physical
           Experiences of Pain in Parkinson's Disease
    • Abstract: SummaryPain is a non-motor symptom of Parkinson's disease (PD) that is often neglected due to its high prevalence in both the PD and the normal elderly population. The aims of this cross-sectional study were to establish the prevalence of pain, investigate its clinical predictors and analyze ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Depression as a Predictor of Occupational Transition in a Multiple
           Sclerosis Cohort
    • Abstract: SummaryIn MS, transitions between working and not-working status may occur in association with depression. This can complicate patients' ability to promptly obtain disability support due to an expectation that their functioning will improve after the depression resolves, a viewpoint that sees ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Use of Botulinum Toxin Type A in the Management of Patients with
           Neurological Disorders: A National Survey
    • Abstract: SummaryThe aim of this survey was to provide an overview of important issues relating to therapeutic strategies based on botulinum toxin type A injection for the treatment of patients with neurological disorders. Two hundred and ten physicians from neurology and neurorehabilitation units in Italian ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Effect of Zolpidem in Chronic Disorders of Consciousness: A Prospective
           Open-Label Study
    • Abstract: SummaryZolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • New Trends in Visual Rehabilitation with MP-1 Microperimeter Biofeedback:
           Optic Neural Dysfunction
    • Abstract: AbstractThe aim of this study was to evaluate the efficacy of visual rehabilitation with MP-1 microperimeter biofeedback in advanced optic neural dysfunction due to glaucoma, and to precisely characterize fixation stability and location in affected patients. Ten patients (18 eyes) with advanced ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Electrophysiological Study of the Bulbocavernosus Reflex: Normative Data
    • Abstract: SummaryIn the clinical setting the bulbocavernosus reflex (BCR) is elicited by squeezing the glans penis and digitally palpating the contraction of the bulbocavernosus (BC) muscle. In neurophysiology the BCR is obtained by stimulating the dorsal nerve of the penis or clitoris and by recording the ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • L'erba Della Regina. Storia Di Un Decotto Miracoloso
    • Abstract: L'erba della Regina. Storia di un decotto miracoloso Paolo Mazzarello Turin, Bollati Boringhieri 2013Lethargic encephalitis is a mysterious infectious disease that appeared at the beginning of the nineteenth century. It exploded suddenly at the end of First World War, leading to a worldwide ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Is an Integrative Perspective Possible in Brain Sciences'
    • Abstract: Dear Reader,Functional Neurology has recently started striving to approach topics from an integrative perspective in order reinforce the links between experimental and clinical studies, and thus favor transitions from basic to applied research, and from the laboratory to the clinic. In short, the ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Oct 2013 00:00:00 -040
       
  • Awake Surgery between Art and Science. Part I: Clinical and Operative
           Settings
    • Abstract: SummaryAwake surgery requires coordinated teamwork and communication between the surgeon and the anesthesiologist, as he monitors the patient, the neuroradiologist as he interprets the images for intraoperative confirmation, and the neuropsychologist and neurophysiologist as they evaluate in ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Imaging Connectivity: MRI and the Structural Networks of the Brain
    • Abstract: SummaryMagnetic resonance imaging (MRI) is a flexible and widely available neuroimaging technique. Structural MRI and diffusion MRI, in particular, provide information about connectivity between brain regions which may be combined to obtain a picture of entire neural networks, or the so-called ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • The XXIV Ottorino Rossi Award
    • Abstract: Who was Ottorino Rossi'Ottorino Rossi was born on 17th January, 1877, in Solbiate Comasco, a tiny Italian village near Como. In 1895 he enrolled at the medical faculty of the University of Pavia as a student of the Ghislieri College and during his undergraduate years he was an intern pupil of the ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Realistic Modeling of Neurons and Networks: Towards Brain Simulation
    • Abstract: SummaryRealistic modeling is a new advanced methodology for investigating brain functions. Realistic modeling is based on a detailed biophysical description of neurons and synapses, which can be integrated into microcircuits. The latter can, in turn, be further integrated to form large-scale brain ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • MRI Observation of Hippocampal Degeneration in Alzheimer's Disease: A
           Forgotten Case
    • Abstract: SummaryAt the beginning of the 1990s, as part of work being done for a master's degree thesis in physics, an important observation of hippocampal degeneration in Alzheimer's disease was made in Pavia. However this result was never published in a full scientific paper. This case gives an idea of how ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Brain Investigation and Brain Conceptualization
    • Abstract: SummaryThe brain of a patient with Alzheimer's disease (AD) undergoes changes starting many years before the development of the first clinical symptoms. The recent availability of large prospective datasets makes it pos sible to create sophisticated brain models of healthy subjects and patients ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • The Human Brain Project and Neuromorphic Computing
    • Abstract: SummaryUnderstanding how the brain manages billions of processing units connected via kilometers of fibers and trillions of synapses, while consuming a few tens of Watts could provide the key to a completely new category of hardware (neuromorphic computing systems). In order to achieve this, a ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Awake Surgery between Art and Science. Part II: Language and Cognitive
           Mapping
    • Abstract: SummaryDirect cortical and subcortical stimulation has been claimed to be the gold standard for exploring brain function. In this field, efforts are now being made to move from intraoperative naming-assisted surgical resection towards the use of other language and cognitive tasks. However, before ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • The Connectomics Challenge
    • Abstract: SummaryOne of the most fascinating challenges in neuroscience is the reconstruction of the connectivity map of the brain. Recent years have seen a rapid expansion in the field of connectomics, whose aim is to trace this map and understand its relationship with neural computation. Many different ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Functional Neurology of a Brain System: A 3D Olfactory Bulb Model to
           Process Natural Odorants
    • Abstract: SummaryThe network of interactions between mitral and granule cells in the olfactory bulb is a critical step in the processing of odor information underlying the neural basis of smell perception. We are building the first computational model in 3 dimensions of this network in order to analyze the ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Foreword
    • Abstract: This special issue of Functional Neurology is devoted to the Human Brain Project (HBP). The HBP is one of the two FET (Future Emerging Technologies) Flagship projects approved this year by the European Commission and its main target is to reach an understanding of the mechanisms of brain ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Seven Challenges for Neuroscience
    • Abstract: SummaryAlthough twenty-first century neuroscience is a major scientific enterprise, advances in basic research have not yet translated into benefits for society. In this paper, I outline seven fundamental challenges that need to be overcome. First, neuroscience has to become "big science" - we need ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Jul 2013 00:00:00 -040
       
  • Development of a High-Resolution Fat and CSF-Suppressed Optic Nerve DTI
           Protocol at 3T: Application in Multiple Sclerosis
    • Abstract: SummaryClinical trials of neuroprotective interventions in mul- tiple sclerosis require outcome measures that reflect the disease pathology. Measures of neuroaxonal in- tegrity in the anterior visual pathways are of particu- lar interest in this context, however imaging of the op- tic nerve is ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Depression, Pain and Quality of Life in Patients with Amyotrophic Lateral
           Sclerosis: A Cross-Sectional Study
    • Abstract: SummaryThe complications related to amyotrophic lateral sclerosis (ALS) include pain. A higher risk of depression and a negative effect on quality of life (QoL) might be expected in ALS patients with pain.The aims of this study were to evaluate the prevalence of pain in ALS patients, to compare ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Differences between Conventional and Non-Conventional MRI Techniques in
           Parkinson's Disease
    • Abstract: SummaryMagnetic resonance imaging (MRI) provides an in vivo assessment of cortical and subcortical regions affected in Parkinson's disease (PD). This review summarizes the most important conventional and non-conventional MRI techniques applied in this field.Standard neuroimaging techniques have ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Psychometric Properties of the Italian Version of the Scales for Outcomes
           in Parkinson's Disease-Cognition (SCOPA-Cog)
    • Abstract: SummaryThe Scales for Outcomes in Parkinson's disease- Cognition (SCOPA-Cog) has been shown to be a clinimetrically rigorous and valid instrument for a disease- oriented neuropsychological assessment of Parkinson's disease (PD) patients. In the present study we evaluated the psychometric properties ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Pure Akinesia: A Kinematic Analysis in a Case Responsive to Rotigotine
    • Abstract: SummaryA patient with pure akinesia is described. This rare gait disorder, poorly responsive to therapy, is characterized by gait impairment which may be associated with handwriting and speech difficulties, in the absence of further signs of extrapyramidal involvement. Here, we report the ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • A Rare Association of Early-Onset Inclusion Body Myositis, Rheumatoid
           
    • Abstract: SummarySporadic inclusion body myositis (sIBM) is a slowly progressive, red-rimmed vacuolar myopathy leading to muscular atrophy and progressive weakness; it predominantly affects males older than fifty years, and is resistant to immunotherapy. It has been described in association with ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Tetrabenazine Improves Levodopa-Induced Peak-Dose Dyskinesias in Patients
           with Parkinson's Disease
    • Abstract: SummarySince levodopa-induced peak dyskinesias (LIDs) may reflect, in part, a disproportionate phasic release of dopamine from synaptic vesicles, we examined the ability of the vesicular depletor tetrabenazine (TBZ) to reduce LIDs in 10 dyskinetic advanced Parkinson's disease (PD) patients. After ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Imaging Multiple Sclerosis outside the Brain
    • Abstract: Multiple sclerosis (MS) is a pathologically and clinically complex and chronic disease of the central nervous sys- tem. It usually presents in young adults and although it follows a highly variable course within and between individ- ual sufferers, it results in serious long-term neurological ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Dermatological and Immunological Conditions Due to Nerve Lesions
    • Abstract: SummarySome syndromes are of interest to both neurologists and dermatologists, because cutaneous involvement may harbinger symptoms of a neurological disease. The aim of this review is to clarify this aspect. The skin, because of its relationships with the peripheral sensory nervous system, ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Non-Genetic Factors Associated with the Risk of Parkinson's Disease in
           Iranian Patients
    • Abstract: SummaryThe aim of this study was to investigate some of nongenetic factors associated with Parkinson's disease (PD) in a sample of Iranian patients.This case-control study included 75 patients with idiopathic PD and 75 control patients.The patients in the control group were found to have drunk more ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Apr 2013 00:00:00 -040
       
  • Abstract VIII Congresso Nazionale Sindem 2013
    • Abstract: Functional connectivity in the Default Mode Network relates to the severity of depression in autosomal recessive Parkinson's diseaseE. Makovac, L. Serra, M. Torso, B. Spanò, S. Petrucci, L. Ricciardi, C. Caltagirone, T. Ialongo, A. Guidubaldi, A. R. Bentivoglio, E. M. Valente, M. BozzaliSaint Lucia ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Comparison of Active Standing Test, Head-Up Tilt Test and 24-H Ambulatory
           Heart Rate and Blood Pressure Monitoring in Diagnosing Postural
           Tachycardia
    • Abstract: SummaryProtocols for the assessment of postural tachycardia differ in both type of orthostatic challenge and test du- ration. We therefore compared heart rate (HR) and blood pressure responses during an active standing test (AST) and a head-up tilt test (HUT) in 34 patients with orthostatic ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Sleep in Ring Chromosome 20 Syndrome: A Peculiar Electroencephalographic
           Pattern
    • Abstract: SummaryRing chromosome 20 [r(20)] syndrome is a chromoso- mal disorder characterized by epilepsy and intellectual disability. Distinctive electroclinical features and wake- fulness EEG patterns have been described. The EEG features of sleep have not yet been evaluated.We studied the pattern of ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Two Cases of Cluster Headache Effectively Treated with Levetiracetam
    • Abstract: Dear Sir,Cluster headache (CH), which is characterized by recurrent attacks of short-lasting excruciating pain accompanied by signs of autonomic dysfunction (ICHD-II) (Headache Classification Subcommittee of the IHS, 2004), is the most se- vere of the primary headache syndromes. CH is the most ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Atypical Language Lateralization: An fMRI Study in Patients with Cerebral
           Lesions
    • Abstract: SummaryDifferences in the lateralization of language processes between healthy subjects and patients with neurologi- cal complaints other than epilepsy have been less doc- umented than those between healthy subjects and epilepsy patients. Moreover, the contribution of factors such as the location ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Whole-Brain Voxel-Based Morphometry Study of Children and Adolescents with
           Down Syndrome
    • Abstract: SummaryIn order to investigate alterations in brain morphology and a possible temporal pattern of neuroanatomical ab- normalities in the gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF) of young patients with Down syndrome (DS), high-resolution magnetic reso- nance imaging (MRI) ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • The Effectiveness of Habit Reversal Therapy in the Treatment of Tourette
           Syndrome and Other Chronic Tic Disorders: A Systematic Review
    • Abstract: SummaryTourette syndrome (TS) is a neurodevelopmental disor- der characterized by multiple tics, which can require active intervention. It is recognized that behavioral techniques, especially habit reversal therapy (HRT), can offer an effective alternative or complement to pharmacotherapy in this ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Evaluation of Autonomies in the Severely Brain Injured: The Progression of
           Autonomies Scale
    • Abstract: SummaryThe aim of this study was to validate the Progression of Autonomies Scale (PAS) for the evaluation of au- tonomies in severe acquired brain injury patients. The PAS design is based on a model of progressive recov- ery of autonomies and is organized in three domains (Personal, Domestic and ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • The Effect of Dopamine Agonists on Cognitive Functions in Non-Demented
           Early-Mild Parkinson's Disease Patients
    • Abstract: SummaryThe effect of dopamine agonists (DAs) on cognition in Parkinson's disease (PD) is not yet completely estab- lished. Previous papers reported a worsening effect on some cognitive functions with some DAs, but not with others, suggesting that DAs may differently affect cog- nition in PD ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • From Bench to Bedside: The Importance for Neurodegenerative Disorders of
           Crosstalk between Basic and Clinical Research
    • Abstract: Dear Reader,A serious limitation of modern medical sciences is the frequent failure to translate the wealth of information provided by preclinical research into commensurate gains in new treatments, diagnostics and prevention. This gap - some- times called the Valley of death' - is particularly ... (Publication: Functional Neurology)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Survey of Practices Employed by Neurologists for the Definition and
           Management of Secondary Non-Response to Botulinum Toxin in Cervical
           Dystonia
    • Abstract: SummarySecondary non-response (SNR) to botulinum toxin (BoNT) in cervical dystonia (CD) lacks a universal definition. We conducted a retrospective survey to develop a definition based on clinicians' practice. Fifty-seven neurologists completed a 17-item questionnaire. In defining SNR, ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • White Matter Integrity Assessed by Diffusion Tensor Tractography in a
           Patient with a Large Tumor Mass but Minimal Clinical and
           Neuropsychological Deficits
    • Abstract: SummaryDiffusion tensor imaging (DTI) tractography and image registration were used to investigate a patient with a massive left-sided brain tumor, whose size was largely disproportionate to his subtle neurological deficits. MRI was obtained from the patient and his healthy identical twin, who ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • New Trends in Pain Research: From Basic Research to Clinical Translation
    • Abstract: The small town of Parghelia on the Tyrrhenian coast (Calabria, Italy) recently provided an attractive setting for a two-year-awaited international meeting on "NEW TRENDS IN PAIN RESEARCH: From Basic Research to Clinical Translation" (13-15 September, 2012).The event, attended by around sixty ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Considerations on a Mutation in the NOTCH3 Gene Sparing a Cysteine
           Residue: A Rare Polymorphism Rather Than a CADASIL Variant
    • Abstract: SummarySome missense mutations and small deletions in the NOTCH3 gene, not involving cysteine residues, have been described in patients considered to be affected by paucisymptomatic CADASIL. However, the significance of such molecular variants is still unclear. We describe a 49-year-old woman with ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Neurogenic Neuroprotection: Clinical Perspectives
    • Abstract: SummaryNeurogenic neuroprotection is a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the deep brain nuclei has been shown to reduce the volume of focal infarction. In this context, protection of neural tissue can be a rapid intervention that has a ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Spatiotemporal and Kinematic Aspects of Obstacle Avoidance in Subjects
           with Down Syndrome
    • Abstract: SummaryObstacle avoidance studies have been extensively performed in normally developed subjects (N), but little work has been done on the characterization of this task in subjects with Down syndrome (DS). The aim of this study was to describe the management of walking with obstacle avoidance in ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Lack of Maintenance of Gait Pattern as Measured by Instrumental Methods
           Suggests Psychogenic Gait
    • Abstract: SummaryFluctuation is a common feature of all psychogenic gait disorder (PGD) patterns. Whether this fluctuation involves only the degree of impairment or whether it affects the gait pattern itself remains an interesting question.We hypothesize that, on repeated measurements, both normal and ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • In Memoriam of Professor Emilia Martignoni (1951-2011): Always Thinking of
           Her
    • Abstract: Now, almost two years since her death, Emilia Martignoni is still greatly missed by everyone who was privileged to know her and to have her as a friend. Emi was a transparent and straightforward person, but at the same time multifaceted. She was a rigorous scientist, a big-hearted and approachable ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • The Human Brain Project
    • Abstract: Dear Reader,In a recent editorial (D'Angelo, 2012), we remarked that, with neuroscience now entering the connectomic era, important projects were expected to be launched in this field by major funding agencies. Now, hot on the heels of confirmation of the EU's approval of the Human Brain Project ... (Publication: Functional Neurology)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Cerebral Oxygenation and Haemodynamic Effects Induced by Nimodipine in
           Healthy Subjects
    • Abstract: SummaryThe cerebrovascular effects of nimodipine are still poorly understood even in the healthy condition; in particular, its effects on tissue oxygenation have never been investigated.The aim of the present study was to investigate changes in cerebral oxygenation and blood volume upon oral ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Technology-Driven Progress
    • Abstract: Dear Reader,If you have been following the recent changes, at editorial level, to Functional Neurology you must be aware of our striving to promote the advancement of outstanding neuroscience and the achievement of coordinated progress of technology, brain science and clinical neurology. If you ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Continuous Intestinal Infusion of Levodopa/carbidopa in Advanced
           Parkinson's Disease: Efficacy, Safety and Patient Selection
    • Abstract: SummaryLong-term oral therapy with levodopa is associated with the development of motor fluctuations and dyskinesia in a large percentage of patients with Parkinson's disease (PD). Motor complications are associated with a number of non-motor symptoms and have a negative impact on disability and ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Early Treatment with High-Dose Interferon Beta-1a Reverses Cognitive and
           Cortical Plasticity Deficits in Multiple Sclerosis
    • Abstract: SummaryAcute inflammation is associated with cognitive deficits and alterations of cortical plasticity in multiple sclerosis (MS). We tested whether early treatment with high-dose interferon (IFN) beta-1a, known to reduce inflammatory activity, improves cortical function and cognitive deficits in ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Relapsing-Remitting Behavioural Variant of Frontotemporal Dementia in a
           Bipolar Patient
    • Abstract: SummaryWe report the case of a bipolar I patient who was diagnosed with frontotemporal dementia at the age of 54 during a manic episode. Her neurological state improved when this episode ended. Each subsequent thymic relapse was associated with cognitive deficits which subsided when the patient ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Physical Therapy Program for Cervical Dystonia: A Study of 20 Cases
    • Abstract: SummaryBotulinum toxin (BTX) is the best therapeutic option in patients with cervical dystonia (CD), but physical therapy (PT) can be added to the treatment to achieve better results. Forty of our 70 patients with CD were enrolled in a controlled open study. Subjects were divided into two groups: ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Finding the Spatial-Numerical Association of Response Codes (SNARC) in
           Signed Numbers: Notational Effects in Accessing Number Representation
    • Abstract: SummaryThe present study investigates basic numerical processing in deaf signers and hearing individuals by evaluating notational effects (Arabic digits vs Italian sign language number signs) and response modality (manual vs pedal) in a parity judgment task. Overall, a standard SNARC effect emerged ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Cortical Excitability and Neurology: Insights into the Pathophysiology
    • Abstract: SummaryTranscranial magnetic stimulation (TMS) is a technique developed to non-invasively investigate the integrity of human motor corticospinal tracts. Over the last three decades, the use of stimulation paradigms including single- pulse TMS, paired-pulse TMS, repetitive TMS, and integration with ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Clinical Differentiation and Outcome Evaluation in Vegetative and
           Minimally Conscious State Patients: The Neurophysiological Approach
    • Abstract: SummaryThe neurophysiological approach to patients with disorders of consciousness allows recording of both central and peripheral nervous system electrical activities and provides a functional assessment. Data obtained using this approach can supplement information from clinical neurological ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Depressive Symptoms among Surrogate Decision Makers in Lebanese ICUs
    • Abstract: SummarySurrogate decision making is advocated to protect the vulnerable patient. Family members of patients in intensive care units (ICUs) are prone to develop depressive symptoms which may undermine their decisional capacity. Lebanon is a multicultural country where paternalism still dominates the ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • Toward the Connectomic Era
    • Abstract: Dear Reader,Neuroscience recently embarked on a new landmark era: in the wake of the Decade of the Brain (1991-2000) and the Decade of Behavior (2001-2010), it has now entered the Decade of the Mind (2011-2020). But what exactly is driving this evolution, and what do these labels actually mean' As ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • Mortality and Prognosis in Patients with Neurogenic Orthostatic
           Hypotension
    • Abstract: SummaryThe prognosis of neurogenic orthostatic hypotension (NOH) has been poorly studied. The aim of this study was to evaluate retrospectively comorbidities and causes of death in patients with NOH. Clinical information and causes of death were obtained for 104 patients (45 with multiple system ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • Lombardia GENS: A Collaborative Registry for Monogenic Diseases Associated
           with Stroke
    • Abstract: SummaryThe Italian region of Lombardy, with its existing stroke centers and high-technology laboratories, provides a favorable context for studying monogenic diseases associated with stroke. The Lombardia GENS project was set up to create a regional network for the diagnosis of six monogenic ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • The Prognostic Value of Motor-Evoked Potentials in Motor Recovery and
           Functional Outcome after Stroke - a Systematic Review of the Literature
    • Abstract: SummaryThe aim of this study was to systematically review published data on the value of motor-evoked potentials (MEPs) in predicting motor recovery of the upper extremity and general functional outcome early after stroke.We searched PubMed for original prognostic studies. Only full-text original ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • A New Approach to Structural Integrity Assessment Based on Axial and
           Radial Diffusivities
    • Abstract: SummaryThis study describes a method for performing diffusivity measures along and across a specific direction, derived from white matter in healthy controls. The diffusion tensor (DT) assigns a principal eigenvector (v^sub 1^) and eigenvalue (axial diffusivity, d^sub ax^) to each voxel. The ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • Evidence of Increased Restless Legs Syndrome Occurrence in Chronic and
           Highly Disabling Migraine
    • Abstract: SummaryThe existence of an association between migraine and restless legs syndrome (RLS) has recently been reported, although the possible implications of this for migraine clinical presentation remain poorly understood. The objectives of this study were to determine RLS frequency in a population ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • A Case for Full Spinal Screening in Trauma Patients without Obvious
           Clinical Signs
    • Abstract: Dear Sir,Motor vehicle accidents with traumatic spinal cord injury are a common reason for emergency department visits. If trauma to the head and neck is suspected, cervical spine imaging is commonly performed (1) but thoracic and lumbar spinal regions are not imaged unless there are clinical signs ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Apr 2012 00:00:00 -050
       
  • Alexithymia may modulate decision making in patients with de novo
           Parkinson's disease
    • Abstract: Summary The aim of this study was to investigate whether and how alexithymia may influence decision making under conditions of uncertainty, assessed using the Iowa Gambling Task, in patients with newly diagnosed, untreated (de novo) Parkinson's disease, as previously reported for healthy subjects. ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Assessing self-awareness of dyskinesias in Parkinson's disease through
           movie materials
    • Abstract: Summary The aim of our study was to determine self-awareness of dyskinesias and other core motor symptoms in Parkinson's disease (PD) through the use of movie presentations. A scale based on 10 movies (five depicting dyskinesias and five showing core symptoms) and the Self-Assessment Parkinson's ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Cerebrovascular reactivity during the Valsalva maneuver in migraine,
           tension-type headache and medication overuse headache
    • Abstract: Summary The aim of this study was to investigate, by means of transcranial Doppler ultrasound (TCD), cerebrovascular reactivity during the Valsalva maneuver (VM) during the headache-free interval in patients with migraine (M), migraine plus tension-type headache (M+TTH), and migraine plus ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Sensitivity and specificity for screening of chronic cerebrospinal venous
           insufficiency using a multimodal non-invasive imaging approach in patients
           with multiple sclerosis
    • Abstract: Summary The aim of this study was to investigate whether a combination of Doppler sonography (DS) and magnetic resonance venography (MRV) on 3T MRI increases specificity for detection of chronic cerebrospinal venous insufficiency (CCSVI) in 171 (113 relapsing-remitting, 47 secondary-progressive, 11 ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Screening for chronic cerebrospinal venous insufficiency (CCSVI) using
           ultrasound. Recommendations for a protocol
    • Abstract: Summary Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by stenoses or obstructions of the internal jugular and/or azygos veins with disturbed flow and formation of collateral venous channels. Ultrasound and venographic studies of the internal jugular and azygos ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Message from the outgoing Editor-in-Chief
    • Abstract: Dear Readers, My personal "Functional Neurology adventure", which began in 2005 when I took over as Editor-in-Chief for two mandates, has now come to its natural conclusion and the time has come to pass the baton to our Associate Editor, Prof. Egidio Ugo D'Angelo, a friend and esteemed scientist. ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Prevalence of extracranial venous abnormalities: results from a sample of
           586 multiple sclerosis patients
    • Abstract: Summary The aim of this study was to assess the prevalence of chronic cerebrospinal venous insufficiency in an unselected cohort of multiple sclerosis (MS) patients. A total of 586 patients with clinically defined MS underwent catheter venography of the internal jugular veins, brachiocephalic veins ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Chronic cerebrospinal venous insufficiency in multiple sclerosis: a
           historical perspective
    • Abstract: Summary Chronic cerebrospinal venous insufficiency (CCSVI) is a term used to describe impaired venous drainage from the central nervous system (CNS) caused by abnormalities in anatomy and flow affecting the extracranial veins. Recently, it has been proposed that CCSVI may contribute to the ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • 'Venous insufficiency' is not the cause of multiple sclerosis (MS) (but it
           could be a risk factor for MS and for different brain disorders)
    • Abstract: In the last four years several studies have been conducted and many articles have been published on the possible role of venous insufficiency in multiple sclerosis (MS). In a preliminary study, published in 2007 by Zamboni et al., 89 MS patients and 60 healthy subjects were investigated using the ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Cerebrospinal fluid flow dynamics in patients with multiple sclerosis: a
           phase contrast magnetic resonance study
    • Abstract: Summary Cerebrospinal fluid (CSF) flow dynamics, which supposedly have a strong relationship with chronic cerebrospinal venous insufficiency (CCSVI), might be expected to be affected in multiple sclerosis (MS) patients. In this study, CSF flow at the level of the cerebral aqueduct was evaluated ... (Publication: Functional Neurology)
      PubDate: Fri, 30 Mar 2012 00:00:00 -050
       
  • Resting-State EEG Study of Comatose Patients: A Connectivity and Frequency
           Analysis to Find Differences between Vegetative and Minimally Conscious
           States
    • Abstract: Summary The aim of this study was to look for differences in the power spectra and in EEG connectivity measures between patients in the vegetative state (VS/UWS) and patients in the minimally conscious state (MCS). The EEG of 31 patients was recorded and analyzed. Power spectra were obtained using ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • Pavia, September, 1961: A Window on Muscles and Nerves
    • Abstract: Summary In September 1961, the First International Congress of Electromyography (EMG) was held at the University of Pavia. This event proved to be a sort of foundation stone for the further development of EMG as an organized field. Many of the most distinguished clinical neurophysiologists attended ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • The Neurological School of Prof. Cornelio Fazio (1950-2010)
    • Abstract: From the lecture delivered by Prof. Cesare Fieschi, MD, PhD, Professor Emeritus of Neurology, University of Rome, winner of the XXII Ottorino Rossi Award. New Series "The Founders of Neurology" - 21 June 2011 I first met Prof. Fazio in Genoa, in 1956, the year in which I graduated and he took up ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • Progression to Dementia in a Population with Amnestic Mild Cognitive
           Impairment: Clinical Variables Associated with Conversion
    • Abstract: Summary The aim of this study was to investigate clinical predictors of, and rates of conversion to, dementia syndrome in a case series of patients with amnestic mild cognitive impairment (aMCI). Two hundred and eight aMCI subjects were followed over a six-year period. A lower Mini Mental State ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • Risk Factors for and Incidence of Subtypes of Ischemic Stroke
    • Abstract: Summary The TOAST classification divides patients with ischemic stroke into five subgroups according to the presumed etiological mechanism. The aims of the present study were to evaluate the distribution of the different etiological stroke subtypes in a hospital-based sample of stroke patients, and ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • The Prognosis of Tourette Syndrome: Implications for Clinical Practice
    • Abstract: Summary Tourette syndrome (TS) is a childhood-onset neuropsychiatric condition characterised by multiple motor and phonic tics. Comorbid behavioural problems are common, especially attention deficit hyperactivity disorder (ADHD) and obsessive-compulsive disorder (OCD). Little is known about the ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • White Matter Microstructure Alterations in Bipolar Disorder
    • Abstract: Summary Genetic, neuropathological and magnetic resonance imaging findings support the presence of diffuse white matter cytoarchitectural disruption in bipolar disorder. In this study, diffusion-weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • Handbook of Clinical Neurology - III Series, Vol. 97 Headache (Elsevier,
           2011)
    • Abstract: Handbook of Clinical Neurology - III Series, Vol. 97 Headache (Elsevier, 2011) Edited by Giuseppe Nappi and Michael Moskowitz This book is the third volume (following the 1968 and 1985 editions) of the Handbook of Clinical Neurology devoted entirely to the vast and complex subject of headaches. The ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • New Trends in Neuroscience: The Challenge of Functional Neurology
    • Abstract: Dear Reader, The rapid development of the neurosciences necessitates continuous updates over a wide range of disciplines, ultimately converging towards a general understanding of the central nervous system (CNS) - its working as well as its possible mechanisms of impairment and recovery. ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • The XXII Ottorino Rossi Award "New Series": The Founders of Neurology
    • Abstract: Who was Ottorino Rossi' Ottorino Rossi was born on 17 January, 1877, in Solbiate Comasco, a tiny Italian village near Como. In 1895 he enrolled at the medical faculty of the University of Pavia as a student of the Ghislieri College and during his undergraduate years he was an intern pupil of the ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
  • Venous Angioplasty in Multiple Sclerosis: Neurological Outcome at Two
           Years in a Cohort of Relapsing-Remitting Patients
    • Abstract: Summary An open study was conducted with the aim of reporting long-term clinical outcome of endovascular treatment for chronic cerebrospinal venous insufficiency (CCSVI) in patients with multiple sclerosis (MS). Twenty-nine patients with clinically definite relapsingremitting MS underwent ... (Publication: Functional Neurology)
      PubDate: Sun, 01 Jan 2012 00:00:00 -060
       
 
 
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