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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.142]   [H-I: 3]   [2 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [2817 journals]
  • Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using
           Proton Nuclear Magnetic Resonance Spectroscopy
    • Authors: Mohamed I.F. Shariff; Jin U. Kim, Nimzing G. Ladep, Mary M.E. Crossey, Larry K. Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I. Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D. Taylor-Robinson
      Abstract: Discriminatory metabolic profiles have been described in urinary 1H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-04-27
      DOI: 10.1016/j.jceh.2016.03.003
       
  • A Rare Congenital Disorder of Intrahepatic Bile Ducts
    • Authors: Krishnasamy Narayanasamy; Jaiganesh Mohan, Kumagurubaran Sivanesan, Shifa Babu, Prem Kumar, Karthick Rajendran
      Abstract: A 34-year-old male presented with chief complaints of jaundice for last 4 weeks and abdominal distension and swelling of the legs for 3 weeks. There was no associated abdominal pain, pale stools, or itching. He is a known diabetic on insulin therapy, and occasionally consumes alcohol. There was no family history of any liver-related diseases. His initial workup showed hemoglobin of 8.8g%, total counts of 9800cells/cumm, and platelets counts of 58000cells/cumm. Liver function tests showed total bilirubin of 13.5, direct bilirubin of 10.4, alanine transaminase of 1560IU/L (normal 8
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-31
      DOI: 10.1016/j.jceh.2016.02.004
       
  • Limited Fibrosis Progression but Significant Mortality in Patients
           Ineligible for Interferon-Based Hepatitis C Therapy
    • Authors: Manhal Izzy; Ghalib Jibara, Aws Aljanabi, Mustafa Alani, Emily Giannattasio, Hina Zaidi, Zaid Said, Paul Gaglio, Allan Wolkoff, John F. Reinus
      Abstract: Individuals ineligible for interferon-based hepatitis C therapy may have a worse prognosis than patients who have failed or not received treatment.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-25
      DOI: 10.1016/j.jceh.2016.02.006
       
  • Long-Term Outcomes of Liver Transplantation for Hepatic Sarcoidosis: A
           Single Center Experience
    • Authors: Muhammad Bilal; Sanjaya K. Satapathy, Mohammad K. Ismail, Jason M. Vanatta
      Abstract: Hepatic sarcoidosis is a rare indication for orthotopic liver transplantation (OLT). Hence, studies evaluating these patients are scarce. We present a single center experience with OLT for hepatic sarcoidosis in a case–control study.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-21
      DOI: 10.1016/j.jceh.2016.02.005
       
  • Honeycomb Cyst of the Liver
    • Authors: Sunil Taneja; Pramod Kumar, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Yogesh Chawla
      Abstract: A 34-year-old female presented with pain in the abdomen for 5 months. The general physical and systemic examination was normal. Ultrasound of abdomen showed two well-defined exophytic multiloculated cystic lesion of size 8.4cm×7cm and 5cm×3.2cm in segment 2/4 and 8 of the liver. Radial endoscopic ultrasound was done to confirm the diagnosis of hydatid cyst, which showed two anechoic multiseptated honeycomb-shaped cysts in liver with daughter cysts and hydatid sand (Figure 1). Later the serology for IgG antibody for hydatidosis came positive in 1:1600 titres.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-19
      DOI: 10.1016/j.jceh.2016.03.001
       
  • Giant-cell Hepatitis—Rare Entity in Adults
    • Authors: Shiran Shetty; Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Vadakkepat Nirmala
      Abstract: Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-16
      DOI: 10.1016/j.jceh.2016.02.007
       
  • Unusual Cause of Cholestatic Jaundice in a Young Immunocompetent Male
    • Authors: Puneet Chhabra; Surinder S. Rana, Deepak Gunjan, Vishal Sharma, Pranab Dey, Deepak K. Bhasin
      Abstract: A 18-year-old boy with no previous comorbidities presented with jaundice, fever, and loss of weight and appetite of one-month duration. He had no previous history of long-standing fatigue, jaundice, ascites, upper gastrointestinal bleeding, or encephalopathy. Based on chest skiagram findings of nonhomogenous opacities in right upper lobe (Figure 1; arrow), he was started on antitubercular therapy (ATT) in an outside medical facility. Following this, he had worsening of jaundice and four weeks later developed progressively increasing abdominal distension.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-15
      DOI: 10.1016/j.jceh.2016.03.002
       
  • Coffee and Liver Disease
    • Authors: Manav Wadhawan; Anil C. Anand
      Abstract: Coffee is the most popular beverage in the world. Consumption of coffee has been shown to benefit health in general, and liver health in particular. This article reviews the effects of coffee intake on development and progression of liver disease due to various causes. We also describe the putative mechanisms by which coffee exerts the protective effect. The clinical evidence of benefit of coffee consumption in Hepatitis B and C, as well as nonalcoholic fatty liver disease and alcoholic liver disease, has also been presented.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-08
      DOI: 10.1016/j.jceh.2016.02.003
       
  • Liver Transplantation for Alcohol-Related Liver Disease
    • Authors: Narendra S. Choudhary; Naveen Kumar, Sanjiv Saigal, Rahul Rai, Neeraj Saraf, Arvinder S. Soin
      Abstract: Alcoholic liver disease (ALD) is a common indication for liver transplantation. It is a much debated indication for deceased donor liver transplantation due to organ shortage and potential of alcohol relapse after liver transplantation. A six-month abstinence before liver transplantation is required at most centers to decrease chances of alcohol relapse after liver transplantation. However, this rule is not relevant for patients with severe alcoholic hepatitis or severely decompensated patients who are unlikely to survive till 6 months.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-07
      DOI: 10.1016/j.jceh.2016.02.001
       
  • Delayed Severe Hemobilia Due to Bilio-venous Fistula After Percutaneous
           Transhepatic Biliary Drainage: Treatment With Covered Stent Placement
    • Authors: Kumble S. Madhusudhan; Nihar R. Dash, Adil Afsan, Shivanand Gamanagatti, Deep N. Srivastava, Arun K. Gupta
      Abstract: Biliovenous fistula occurs due to development of a communication between hepatic duct and portal vein branches and is a rare complication of percutaneous transhepatic biliary drainage (PTBD). Most of them are self-limiting and only occasionally they need interventional management. Placement of biliary stent graft is a viable option. We present here a case of a 56-year-old male with carcinoma of gall bladder presenting with hemodynamic shock due to severe hemobilia after PTBD and treated successfully by biliary covered stent placement.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-04
      DOI: 10.1016/j.jceh.2016.02.002
       
  • Addition of Dexamethasone Alters the Bile Acid Composition by Inducing
           CYP8B1 in Primary Cultures of Human Hepatocytes
    • Abstract: Primary human hepatocytes offer the best human in vitro model for studies on human liver cell metabolism. Investigators use a variety of different media supplements and matrix biocoatings and the type of culture system used may influence the outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-22
      DOI: 10.1016/j.jceh.2016.01.007
       
  • Acute Liver Failure Caused by Hepatitis A Virus with Dengue Coinfection
    • Authors: Sunil Taneja; Amritangsu Borakokty, Ajay Duseja, Radha Krishan Dhiman, Yogesh Chawla
      Abstract: Hepatitis A (HAV) infection and dengue fever are endemic in developing countries and are associated with increased morbidity and mortality. Both the infections are commonly seen during the rainy season and are associated with poor sanitation and low socioeconomic status.1 Due to diverse presentation, their coexistence can present a diagnostic dilemma and at times a difficult clinical scenario to manage due to the complicated course of the illness.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-10
      DOI: 10.1016/j.jceh.2016.01.006
       
  • Hemodynamic Response to Carvedilol is Maintained for Long Periods and
           Leads to Better Clinical Outcome in Cirrhosis: A Prospective Study
    • Authors: Vijendra Kirnake; Anil Arora, Varun Gupta, Praveen Sharma, Vikas Singla, Naresh Bansal, Mohan Goyal, Romesh Chawlani, Ashish Kumar
      Abstract: Non-selective beta-blockers (NSBBs), e.g. propranolol, are recommended for prophylaxis of variceal bleeding in cirrhosis. Carvedilol, a newer NSBB with additional anti-α1-adrenergic activity, is superior to propranolol in reducing portal pressure. Repeated HVPG measurements are required to identify responders to NSBB. We aimed to determine whether a single-time HVPG measurement, using acute-hemodynamic-response-testing, is sufficient to predict long-term response to carvedilol, and whether these responders have better clinical outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-06
      DOI: 10.1016/j.jceh.2016.01.004
       
  • Dengue Virus Transmission from Living Donor to Recipient in Liver
           Transplantation: A Case Report
    • Authors: Raman K. Gupta; Gaurav Gupta, Vishal K. Chorasiya, Pradyut Bag, Rajeev Shandil, Vikram Bhatia, Manav Wadhawan, Vivek Vij, Ajay Kumar
      Abstract: Many infections are transmitted from a donor to a recipient through organ transplantations. The transmission of dengue virus from a donor to a recipient in liver transplantation is a rare entity, and currently, there is no recommendation for screening this virus prior to transplantation. We report a case of transmission of dengue virus from donor to recipient after liver transplantation. The recipient had a history of multiple admissions for hepatic encephalopathy and ascites. He was admitted in the ICU for 15 days for chronic liver disease, ascites, and acute kidney injury before transplantation.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-04
      DOI: 10.1016/j.jceh.2016.01.005
       
  • Innovative Approach of Using Esophageal Stent for Refractory Post-Band
           Ligation Esophageal Ulcer Bleed Following Living Donor Liver
           Transplantation
    • Authors: Narendra S. Choudhary; Rajesh Puri, Sanjiv Saigal, Neeraj Saraf, Randhir Sud, Arvinder S. Soin
      Abstract: Bleeding from post-banding esophageal ulcers is uncommon. It is associated with significant morbidity and mortality. The bleeding from post-banding ulcers is difficult to manage and may be refractory to endotherapy and pharmacological treatment; transjugular intrahepatic portosystemic shunt can be used in such cases. We present a case of refractory post-banding ulcer bleed in a liver transplant recipient, which was managed by placement of removable esophageal metal stent.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-29
      DOI: 10.1016/j.jceh.2016.01.003
       
  • Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate
           LX-2 Cells
    • Authors: Devaraj Ezhilarasan; Jonathan Evraerts, Sid Brice, Pedro Buc-Calderon, Sivanesan Karthikeyan, Etienne Sokal, Mustapha Najimi
      Abstract: Proliferation of hepatic stellate cells (HSCs) play pivotal role in the progression of hepatic fibrosis consequent to chronic liver injury. Silibinin (SBN), a flavonoid compound, has shown to possess cell cycle arresting potential against many actively proliferating cancers cell lines. The objective of this study was to evaluate the anti-proliferative and cell cycle arresting properties of SBN in rapidly proliferating human hepatic stellate LX-2 cell line.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-29
      DOI: 10.1016/j.jceh.2016.01.002
       
  • A Rare Presentation of Leishmaniasis
    • Authors: Ritesh Prajapati; Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Shashi Dhawan, Anil Arora
      Abstract: Leishmaniasis or kala-azar is a protozoan disease that can present as cutaneous, mucocutaneous, visceral, and disseminated disease. In India, it is usually localized in distinct areas of Bihar, Jharkhand, West Bengal, and parts of Eastern Uttar Pradesh. Visceral leishmaniasis (VL) involves the visceral organs, mainly the liver, the spleen and bone marrow. VL is characterized by prolonged fever, massive splenomegaly, weight loss, progressive anemia, pancytopenia, and hypergammaglobulinemia, and can be complicated by serious infections.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-23
      DOI: 10.1016/j.jceh.2016.01.001
       
  • Liver Transplantation in India: At the Crossroads
    • Authors: Sanjay Nagral; Aditya Nanavati, Aabha Nagral
      Pages: 329 - 340
      Abstract: As the liver transplant journey in India reaches substantial numbers and suggests quality technical expertise, it is time to dispassionately look at the big picture, identify problems, and consider corrective measures for the future. Several features characterize the current scenario. Although the proportion of deceased donor liver transplants is increasing, besides major regional imbalances, the activity is heavily loaded in favor of the private sector and live donor transplants. The high costs of the procedure, the poor participation of public hospitals, the lack of a national registry, and outcomes reporting are issues of concern.
      Citation: Journal of Clinical and Experimental Hepatology 5, 4 (2015)
      PubDate: 2015-12
      DOI: 10.1016/j.jceh.2015.11.001
      Issue No: Vol. 5, No. 4 (2015)
       
  • Journal of Clinical and Experimental Hepatology 5, 4 (2015)
    • Authors: Vivek A. Saraswat; Gaurav Pandey
      First page: 348
      Abstract: This, one-of-its kind book, is an excellent and timely state-of-the-art review of Hepatitis C in December 2015. Though billed as ‘A Complete Guide for Patients and Families’, this book is actually a complete guide to the student internist, the family physician, other professionals caring for hepatitis C patients and even the non-hepatologist caring for patients who suffer from hepatitis C, among other problems. Its simple, easy-to-follow language and uncluttered syntax makes it the ideal companion volume to more comprehensive tomes on hepatitis C and for understanding the torrent of literature gushing out of the hepatitis C pipeline that is in flood since 2011.
      PubDate: 2015-12
      DOI: 10.1016/j.jceh.2015.12.004
      Issue No: Vol. 5, No. 4 (2015)
       
  • Pyoderma Gangrenosum—A New Manifestation of Wilson Disease?
    • Authors: George Naiem Ibrahiem Freg; Venisha Shah, Aabha Nagral, Ajay Jhaveri
      Abstract: Seventeen year old girl, a known case of Wilson disease presented to us with a non-healing skin ulcer followed by appearance of jaundice, ascites and progressive fatigue of 1 month duration. She was diagnosed to have Wilson disease 5 years back and had been well controlled on d-penicillamine. On enquiry, she was found to be noncompliant with her medication in the preceding 6 months. On examination, she had severe pallor, icterus with moderate ascites and oedema feet. Investigations revealed severe haemolytic anemia and deranged liver function.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-21
      DOI: 10.1016/j.jceh.2015.11.005
       
  • PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in
           Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three
           Prospective Studies
    • Abstract: There are no univocal opinions on the role of genetic thrombophilia on splanchnic vein thrombosis (SVT). We defined genetic thrombophilia the presence of one of these thrombophilic genetic factors (THRGFs): PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and prothrombin 20210A.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.002
       
  • Changes in Liver Volume in Patients with Chronic Hepatitis C Undergoing
           Antiviral Therapy
    • Authors: Julie A. Fitzpatrick; Jin Un Kim, Jeremy F.L. Cobbold, Mark J.W. McPhail, Mary M.E. Crossey, Aluel A. Bak-Bol, Ashraf Zaky, Simon D. Taylor-Robinson
      Abstract: Liver volumetric analysis has not been used to detect hepatic remodelling during antiviral therapy before. We measured liver volume (LV) changes on volumetric magnetic resonance imaging during hepatitis C antiviral therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.004
       
  • Variceal Banding: A Lesser-Known Complication
    • Authors: Ashish Kumar Jha; Vishwa Mohan Dayal, Baraq Ahmed, Uday Kumar, Sharad Kumar
      Abstract: Band ligation is the cornerstone of the treatment of esophageal varices. Band ligation is one of the most commonly performed endoscopic procedures. Although variceal banding is mostly a safe procedure, it may be complicated by serious adverse event.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
       
  • Donor Factors Including Donor Risk Index Predict Fibrosis Progression,
           Allograft Loss, and Patient Survival following Liver Transplantation for
           Hepatitis C Virus
    • Authors: Arun Jesudian; Sameer Desale, Jonathan Julia, Elizabeth Landry, Christopher Maxwell, Bhaskar Kallakury, Jacqueline Laurin, Kirti Shetty
      Abstract: The utilization of liver transplantation (LT) is limited by the availability of suitable organs. This study aimed to assess the impact of the donor risk index (DRI) and other donor characteristics on fibrosis progression, graft, and patient survival in hepatitis C virus (HCV)-infected LT recipients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
       
  • “Hockey Stick” may Strike Back: Hepatocellular Carcinoma on
           Noncirrhotic Liver as a Late Toxicity of Lombo-Aortic Radiotherapy for
           Seminoma. A Review Triggered by an Unusual Case
    • Authors: Clement Korenbaum; Philippe Barthelemy, Alina Onea, Pierre Salze, Jean-Emmanuel Kurtz
      Abstract: Most patients with testicular seminoma have been treated with a curative intent for decades. Second cancers after radiotherapy for testicular seminoma before 1990 are a growing issue, and are related to previous generation of dose planning and delineating strategies. Among those cancers, hepatocellular carcinoma is an extremely rare occurrence, especially when affecting patients with healthy, noncirrhotic liver. Here, we describe such a case in a patient of our institution, and subsequently review the relevant literature and large epidemiologic studies.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
       
  • Multiplex Reverse Transcriptase-PCR for Simultaneous Detection of
           Hepatitis B, C, and E Virus
    • Authors: Gunjan Garg; Deepak Kumar, Mohammad Asim, Syed Akhtar Husain, Bhudev C. Das, Premashis Kar
      Abstract: The hepatitis B virus (HBV), HCV, and HEV may occur as singly or concurrently in patients of different kind of liver disease. The rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. Therefore, a study has been planned to develop a multiplex Reverse Transcriptase-PCR assay which can be used for the screening of maximum number of pathogens at a time.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-30
       
  • Driving Performance Among Patients with Cirrhosis Who Drove to Their
           Outpatient Hepatology Clinic Appointments
    • Authors: Paul J. Thuluvath; Anantha Nuthalapati, Jennifer Price, Anurag Maheshwari
      Abstract: Minimal hepatic encephalopathy (MHE) may adversely affect driving skills.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-15
      DOI: 10.1016/j.jceh.2015.09.003
       
  • Acute-On-Chronic Liver Failure (ACLF) in Coastal Eastern India: “A
           Single-Center Experience”
    • Authors: Girish Kumar Pati; Ayaskanta Singh, Bijay Misra, Debasis Misra, Haribhakti Seba Das, Chittaranjan Panda, Shivaram Prasad Singh
      Abstract: Acute-On-Chronic liver failure (ACLF) is an emerging entity. The present study was undertaken to analyze the clinical profile and natural course of ACLF patients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-01
      DOI: 10.1016/j.jceh.2015.08.002
       
  • Hepatitis C Virus (HCV) Infection in Patients with End Stage Renal
           Disease: A Study from a Tertiary Care Centre in India
    • Authors: Anil Arora; Naresh Bansal, Praveen Sharma, Vikas Singla, Varun Gupta, Pankaj Tyagi, Manish Malik, Ashish Kumar
      Abstract: Hepatitis C Virus (HCV) infection is common in patients with end stage renal disease (ESRD) and is an important cause of liver disease. We describe the demographic, clinical and biochemical profile of these patients from a tertiary care center of north India.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-05-15
      DOI: 10.1016/j.jceh.2015.04.004
       
  • Dopamine and Furosemide for the Treatment of Hepatorenal Syndrome: A
           Reappraisal or Just Smoke and Mirrors?
    • Authors: Salvatore Piano; Paolo Angeli
      First page: 273
      Abstract: Patients with advanced cirrhosis have a high to develop extrahepatic organ failures. Renal failure is common in patients with advanced cirrhosis and hepatorenal syndrome (HRS) represents the most life-threatening type of renal failure in these patients.1 Until 30 years ago, no effective treatment of HRS was available and short-term mortality was almost 100% in these patients.2 With the advent of orthotopic liver transplantation (OLT), HRS became an indication to OLT since it was shown that HRS resolved in most of the liver transplant recipients with a deep impact on survival.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-22
      DOI: 10.1016/j.jceh.2015.12.003
       
  • Randomized Controlled Trial Comparing the Efficacy of Terlipressin and
           Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin
           in Hepatorenal Syndrome
    • Authors: Siddharth Srivastava; Shalimar, Sreenivas Vishnubhatla, Shyam Prakash, Hanish Sharma, Bhaskar Thakur, Subrat K. Acharya
      First page: 276
      Abstract: Terlipressin with albumin is recommended in hepatorenal syndrome (HRS). Terlipressin is expensive and not licensed in many countries. Alternative therapy is necessary. We compared the efficacy of terlipressin and albumin with concurrent low-dose dopamine, furosemide, and albumin in HRS.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-10
      DOI: 10.1016/j.jceh.2015.08.003
       
  • Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma:
           Potential Modulation Through Quinolone Administration
    • Authors: Mohamed I.F. Shariff; Joshua M. Tognarelli, Matthew R. Lewis, Elizabeth J. Want, Fatma El Zahra Mohamed, Nimzing G. Ladep, Mary M.E. Crossey, Shahid A. Khan, Rajiv Jalan, Elaine Holmes, Simon D. Taylor-Robinson
      First page: 286
      Abstract: The primary aim of this study was to characterise the blood metabolic profile of hepatocellular carcinoma (HCC) in a rat model, and the secondary aim was to evaluate the effect of the quinolone, norfloxacin on metabolic profiles and exploring the role that gut sterilisation may have on HCC development.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-29
      DOI: 10.1016/j.jceh.2015.07.205
       
  • Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians:
           A Case–Control Study
    • Authors: Shivaram P. Singh; Ayaskanta Singh, Debasis Misra, Bijay Misra, Girish K. Pati, Manas K. Panigrahi, Sanjib K. Kar, Pallavi Bhuyan, Kaumudee Pattnaik, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Manoroma Swain, Palok Aich
      First page: 295
      Abstract: NAFLD has today emerged as the leading cause of liver disorder. There is scanty data on risk factors associated with NAFLD emanating from India. The present study was conducted to identify the risk factors associated with NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-29
      DOI: 10.1016/j.jceh.2015.09.001
       
  • Role of Transient Elastography (Fibroscan) in Differentiating Severe Acute
           Hepatitis and Acute on Chronic Liver Failure
    • Authors: Praveen Sharma; Rinkesh Bansal, Abdul Matin, Pankaj Tyagi, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      First page: 303
      Abstract: It is difficult to differentiate acute severe hepatitis (AH) with acute on chronic liver failure (ACLF). Aim was to study the role of transient elastography (Fibroscan) in identifying the patients with AH and ACLF.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-27
      DOI: 10.1016/j.jceh.2015.09.004
       
  • Safety of Ascitic Paracentesis in Patients with Budd-Chiari Syndrome on
           Oral Anticoagulation and Elevated International Normalized Ratio
    • Authors: Harshad Devarbhavi; Arvind R. Murali
      First page: 310
      Abstract: Anticoagulation is the standard of care in patients with Budd-Chiari Syndrome (BCS). Ascites is a common symptom in patients with BCS. Often such patients require paracentesis while taking oral anticoagulation concurrently. It is unclear whether paracentesis leads to increased bleeding in such patients or whether anticoagulation has to be temporarily suspended. We describe our experience with paracentesis in patients with BCS taking oral anticoagulation.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-15
      DOI: 10.1016/j.jceh.2015.08.004
       
  • Indications of Liver Biopsy in the Era of Noninvasive Assessment of Liver
           Fibrosis
    • Authors: Deepak Amarapurkar; Anjali Amarapurkar
      First page: 314
      Abstract: Liver biopsy (LB) has been used as diagnostic modality in liver diseases (LD). Over last two decades, there has been remarkable improvement in understanding of natural history, molecular diagnostics of viral hepatitis, genetic of LD, and also limitations of LB. There is current trend in avoiding LB in the management of various LDs.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-28
      DOI: 10.1016/j.jceh.2015.08.005
       
  • Magnetic Resonance Spectroscopy: Principles and Techniques: Lessons for
           Clinicians
    • Authors: Joshua M. Tognarelli; Mahvish Dawood, Mohamed I.F. Shariff, Vijay P.B. Grover, Mary M.E. Crossey, I. Jane Cox, Simon D. Taylor-Robinson, Mark J.W. McPhail
      First page: 320
      Abstract: Magnetic resonance spectroscopy (MRS) provides a non-invasive ‘window’ on biochemical processes within the body. Its use is no longer restricted to the field of research, with applications in clinical practice increasingly common. MRS can be conducted at high magnetic field strengths (typically 11–14T) on body fluids, cell extracts and tissue samples, with new developments in whole-body magnetic resonance imaging (MRI) allowing clinical MRS at the end of a standard MRI examination, obtaining functional information in addition to anatomical information.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-30
       
  • Primary Liver Sinusoidal Non-Hodgkin's Lymphoma Presenting as Acute Liver
           Failure
    • Authors: Aabha Nagral; Ajay Jhaveri, Vilesh Kalthoonical, Ganapathi Bhat, Pravin Mahajan, Anita Borges
      First page: 341
      Abstract: We describe a case of a middle-aged woman, who presented to us with fever, anorexia, abdominal distension from a massive hepatomegaly, low hemoglobin, and acute liver failure. A liver biopsy revealed B cell non-Hodgkin's lymphoma predominantly in the sinusoids with CD10, CD20, and Bcl-2 positive on immunohistochemistry. She initially responded well to chemotherapy but succumbed 6 months later to the recurrence of disease. Sinusoidal non-Hodgkin's lymphoma of the liver should be considered in the differential diagnosis of a patient with large hepatomegaly presenting with acute liver failure.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-15
       
  • Liver Transplantation After Bone Marrow Transplantation for End Stage
           Liver Disease with Severe Hepatopulmonary Syndrome in Dyskeratosis
           Congenita: A Literature First
    • Authors: Shyam Sunder Mahansaria; Senthil Kumar, Kishore G.S. Bharathy, Sachin Kumar, Viniyendra Pamecha
      First page: 344
      Abstract: Dyskeratosis congenita is a multisystem genetic disorder. Although hepatic involvement is reported in about 7% of patients with dyskeratosis congenita, it is not well characterized and often attributed to hemochromatosis from frequent blood transfusions. A few case reports describe cirrhosis and hepatic cell necrosis in affected individuals in autosomal dominant pedigrees. Bone marrow failure and malignancies are the principal causes of death in dyskeratosis congenita. We describe the first case of living donor liver transplantation, in dyskeratosis congenita for decompensated cirrhosis with portal hypertension.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
       
  • Upper Gastrointestinal Bleed Following Percutaneous Liver Abscess Drainage
    • Authors: Hemanta K. Nayak; Vivek A. Saraswat, Samir Mohindra, Raghunandan Prasad, Arun Karyampudi
      First page: 349
      Abstract: A 55-year-old male was admitted to a community hospital with right upper quadrant pain and fever for two weeks. Ultrasonography showed a large right lobe liver abscess (volume 350mm3), for which he received intravenous injection metronidazole 800mg thrice daily with injection ceftriaxone 1g twice daily for seven days without any improvement. A percutaneous drain was placed successfully in the liver abscess and drained creamy pus. One week later, the percutaneous catheter was removed after improvement of symptoms.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-14
      DOI: 10.1016/j.jceh.2015.06.009
       
  • Use of Non-selective Beta-blockers in Decompensated Cirrhosis: Controversy
           Continues
    • Authors: Shalimar
      First page: 352
      Abstract: J Hepatol. Online first (doi:10.1016/j.jhep.2015.10.018). Reference: JHEPAT 5868
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.003
       
  • Hepatobiliary Quiz—16 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      First page: 355
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-22
      DOI: 10.1016/j.jceh.2015.12.001
       
  • Hepatobiliary Quiz (Answers)—16 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      First page: 357
      Abstract: Liver transplant recipients are twice as prone to develop malignancies as compared to the general population.1–4 The risk is most in patients transplanted for alcohol-related liver disease or primary sclerosing cholangitis (PSC).3–5 The most common malignancies in this population include dermatological cancers, post-transplantation lymphoproliferative disease and gastrointestinal, lung, oropharyngeal and gynecological solid tumors.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-21
      DOI: 10.1016/j.jceh.2015.12.002
       
 
 
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