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Journal Cover   Journal of Clinical and Experimental Hepatology
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   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [2589 journals]
  • Reprint of: Nutrition in the Management of Cirrhosis and its Neurological
           Complications
    • Authors: Chantal Bémeur; Roger F. Butterworth
      Abstract: Malnutrition is a common feature of chronic liver diseases that is often associated with a poor prognosis including worsening of clinical outcome, neuropsychiatric complications as well as outcome following liver transplantation. Nutritional assessment in patients with cirrhosis is challenging owing to confounding factors related to liver failure. The objectives of nutritional intervention in cirrhotic patients are the support of liver regeneration, the prevention or correction of specific nutritional deficiencies and the prevention and/or treatment of the complications of liver disease per se and of liver transplantation.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-02-20
      DOI: 10.1016/j.jceh.2015.02.004
       
  • Clinical and Biochemical Profile of Tuberculosis in Patients with Liver
           Cirrhosis
    • Authors: Praveen Sharma; Pankaj Tyagi, Vikas Singla, Naresh Bansal, Ashish Kumar, Anil Arora
      Abstract: There is paucity of data on tuberculosis and antituberculous therapy (ATT) induced hepatotoxicity in patients with chronic liver disease.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-02-05
      DOI: 10.1016/j.jceh.2015.01.003
       
  • Intrahepatic Cholangiocarcinoma Masquerading as Liver Abscess
    • Authors: Vinit Shah; Anil Arora, Pankaj Tyagi, Praveen Sharma, Naresh Bansal, Vikas Singla, Rinkesh K. Bansal, Varun Gupta, Ashish Kumar
      Abstract: Malignancy masquerading as liver abscess, and presenting with fever, is mainly described in patients with colorectal cancers with liver metastasis. Primary liver tumors such as hepatocellular carcinoma or intrahepatic cholangiocarcinoma presenting as non-resolving liver abscess is extremely uncommon and carries a dismal prognosis. We present a rare case of non-resolving liver abscess as a presenting manifestation of intrahepatic cholangiocarcinoma.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-02-02
      DOI: 10.1016/j.jceh.2014.12.006
       
  • Study of the Effects of Cyclooxygenase-2 Inhibitor on the Promotion of
           Hepatic Tumorigenesis in Rats Fed a High Fat Diet
    • Authors: Magda Hamzawy; Laila Elsaid, Asmaa Shams, Laila Rashid, Soheir Mahfouz, Nivin Sharawy
      Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The highest prevalence of hepatitis is an important risk factor contributing to development of HCCs. However, an increasing number of cases are associated metabolic disease and steatohepatitis. Inflammation associated with many liver disease, seems to be a necessary pre-requisite for successful tumor initiation. Mechanisms that link high fat diet and inflammation initial stage of HCC are not completely understood.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-01-29
      DOI: 10.1016/j.jceh.2014.12.010
       
  • Pregnancy and Vascular Liver Disease
    • Authors: Julien Bissonnette; François Durand, Emmanuelle de Raucourt, Pierre-François Ceccaldi, Aurélie Plessier, Dominique Valla, Pierre-Emmanuel Rautou
      Abstract: Vascular disorders of the liver frequently affect women of childbearing age. Pregnancy and the postpartum are prothrombotic states. Pregnancy seems to be a trigger for Budd–Chiari syndrome in patients with an underlying prothrombotic disorder. Whether pregnancy is a risk factor for other vascular liver disorders is unknown.In women with a known vascular liver disorder and a desire for pregnancy, stabilisation of the liver disease, including the use of a portal decompressive procedure when indicated, should be reached prior to conception.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-01-20
      DOI: 10.1016/j.jceh.2014.12.007
       
  • Amoebic Liver Abscess with Hepatic Artery Pseudoaneurysm: Successful
           Treatment by Interventional Radiology
    • Authors: Ajit K. Yadav; Saumya Gupta, Sudarsan Hariprasad, Ashish Kumar, Samarjit S. Ghuman, Arun Gupta
      Abstract: Amoebic liver abscess is most common extra-intestinal presentation of amoebiasis. It is rarely complicated with vascular involvement including thrombosis of hepatic vein or IVC and pseudo-aneurysm of hepatic artery. We describe a case of hepatic artery pseudo-aneurysm as a complication of amoebic liver abscess treated with percutaneous embolization.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-01-16
      DOI: 10.1016/j.jceh.2014.12.009
       
  • Gut Microbiota: Its Role in Hepatic Encephalopathy
    • Authors: Rahul Rai; Vivek A. Saraswat, Radha K. Dhiman
      Abstract: Ammonia, a key factor in the pathogenesis of hepatic encephalopathy (HE), is predominantly derived from urea breakdown by urease producing large intestinal bacteria and from small intestine and kidneys, where the enzyme glutaminases releases ammonia from circulating glutamine. Non-culture techniques like pyrosequencing of bacterial 16S ribosomal ribonucleic acid are used to characterize fecal microbiota. Fecal microbiota in patients with cirrhosis have been shown to alter with increasing Child-Turcotte-Pugh (CTP) and Model for End stage Liver Disease (MELD) scores, and with development of covert or overt HE.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-01-06
      DOI: 10.1016/j.jceh.2014.12.003
       
  • Hepatic Encephalopathy: Historical Remarks
    • Authors: Piero Amodio
      Abstract: The history of hepatic encephalopathy (HE) is briefly reviewed since the beginning of western medicine by Hippocrates. For about 2000 years the main evidence was the mere association between jaundice, fever and delirium. A clear link between delirium and cirrhosis was proven in the 17th century by Morgagni. In subsequent times the focus was manly the descriptions of symptoms and the only pathophysiological improvement was the evidence that jaundice, per se, does not alter brain function. Only at the end of the 19th century Hann et al proved the role of portal-systemic shunt and pf nitrogenous derivates in the pathophysiology of the syndrome.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-25
      DOI: 10.1016/j.jceh.2014.12.005
       
  • Management in Acute Liver Failure
    • Authors: Shalimar; Subrat K. Acharya
      Abstract: Acute liver failure (ALF) is a rare, potentially fatal complication of severe hepatic illness resulting from various causes. In a clinical setting, severe hepatic injury is usually recognised by the appearance of jaundice, encephalopathy and coagulopathy. The central and most important clinical event in ALF is occurrence of hepatic encephalopathy (HE) and cerebral edema which is responsible for most of the fatalities in this serious clinical syndrome. The pathogenesis of encephalopathy and cerebral edema in ALF is unique and multifactorial.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-19
      DOI: 10.1016/j.jceh.2014.11.005
       
  • Minimal Hepatic Encephalopathy Impairs Quality of Life
    • Authors: Swastik Agrawal; Sridharan Umapathy, Radha K. Dhiman
      Abstract: Minimal hepatic encephalopathy (MHE) is the mildest form of the spectrum of neurocognitive impairment in cirrhosis. It is a frequent occurrence in patients of cirrhosis and is detectable only by specialized neurocognitive testing. MHE is a clinically significant disorder which impairs daily functioning, driving performance, work capability and learning ability. It also predisposes to the development of overt hepatic encephalopathy, increased falls and increased mortality. This results in impaired quality of life for the patient as well as significant social and economic burden for health providers and care givers.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-17
      DOI: 10.1016/j.jceh.2014.11.006
       
  • Definition and Nomenclature of Hepatic Encephalopathy
    • Authors: Narayan Dharel; Jasmohan S. Bajaj
      Abstract: Hepatic encephalopathy (HE) can manifest with a broad range of neuropsychiatric abnormalities of varying severity, acuity and time course with significant clinical implications. Lack of precise nomenclature and classification had hampered research in this complex clinical problem. A multiaxial classification system based on underlying etiology, clinical severity, time course and presence or absence of precipitating factors has been developed over the recent years and has been fully incorporated in the newly published AASLD-EASL guidelines on HE management.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-11-28
       
  • Acute-on-Chronic Liver Failure: Recent Concepts
    • Authors: Richard Moreau; Rajiv Jalan, Vicente Arroyo
      Abstract: A proportion of patients hospitalized for an acute complication of cirrhosis are at high risk of short-term death. The term Acute-on-Chronic Liver Failure (ACLF) is used to characterize these patients. Until recently there was no evidence-based definition of ACLF. In 2013 a definition has been proposed based on results of a large prospective observational European study, called “European Association for the Study of the Liver (EASL)–Chronic Liver Failure (CLIF) Consortium Acute-on-Chronic Liver Failure in Cirrhosis (CANONIC)” study.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-10-03
      DOI: 10.1016/j.jceh.2014.09.003
       
  • Encephalopathy in Wilson Disease: Copper Toxicity or Liver Failure'
    • Authors: Peter Ferenci; Tomasz Litwin, Joanna Seniow, Anna Czlonkowska
      Abstract: Hepatic encephalopathy (HE) is a complex syndrome of neurological and psychiatric signs and symptoms that is caused by portosystemic venous shunting with or without liver disease irrespective of its etiology. The most common presentation of Wilson disease (WD) is liver disease and is frequently associated with a wide spectrum of neurological and psychiatric symptoms. The genetic defect in WD leads to copper accumulation in the liver and later in other organs including the brain. In a patient presenting with Wilsonian cirrhosis neuropsychiatric symptoms may be caused either by the metabolic consequences of liver failure or by copper toxicity.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-20
      DOI: 10.1016/j.jceh.2014.09.002
       
  • Acute Portal Vein Thrombosis, No Longer a Contraindication for
           Transjugular Intrahepatic Porto-Systemic Shunt (TIPS) Insertion
    • Authors: Suraj Mammen; Shyamkumar N. Keshava, Sajith Kattiparambil
      Abstract: Portal vein thrombosis, once considered as a contraindication to transjugular intrahepatic porto-systemic shunt (TIPS) is now considered as an indication. We report a case with clinical and technical success in a patient with Budd Chiari syndrome and acute portal venous thrombosis. Though it is a well-established option, with the best of our knowledge, we could not find a report from India.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-20
      DOI: 10.1016/j.jceh.2014.08.008
       
  • Neuroinflammation in Hepatic Encephalopathy: Mechanistic Aspects
    • Authors: Arumugam R. Jayakumar; Kakulavarapu V. Rama Rao, Michael D. Norenberg
      Abstract: Hepatic encephalopathy (HE) is a major neurological complication of severe liver disease that presents in acute and chronic forms. While elevated brain ammonia level is known to be a major etiological factor in this disorder, recent studies have shown a significant role of neuroinflammation in the pathogenesis of both acute and chronic HE. This review summarizes the involvement of ammonia in the activation of microglia, as well as the means by which ammonia triggers inflammatory responses in these cells.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-08-05
      DOI: 10.1016/j.jceh.2014.07.006
       
  • Clinical Neurophysiology of Hepatic Encephalopathy
    • Authors: Piero Amodio; Sara Montagnese
      Abstract: Hepatic encephalopathy (HE) has relevant impact on the quality of life of patients and their caregivers and causes relevant costs because of hospitalizations and work days lost. Its quantification is important to perform adequate clinical trials on this relevant complication of cirrhosis and portal-systemic shunting. Clinical neurophysiology, which detects functional alterations of the nervous system, has been applied to the study of HE for over 60 years. This review aims at summarizing and clarifying the role of neurophysiologic techniques in the study of HE.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-08-03
      DOI: 10.1016/j.jceh.2014.06.007
       
  • Diagnosis of Minimal Hepatic Encephalopathy
    • Authors: Karin Weissenborn
      Abstract: Minimal hepatic encephalopathy (mHE) has significant impact upon a liver patient's daily living and health related quality of life. Therefore a majority of clinicians agree that mHE should be diagnosed and treated. The optimal means for diagnosing mHE, however, is controversial. This paper describes the currently most frequently used methods—EEG, critical flicker frequency, Continuous Reaction time Test, Inhibitory Control Test, computerized test batteries such as the Cognitive Drug Research test battery, the psychometric hepatic encephalopathy score (PHES) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)—and their pros and cons.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-07-31
      DOI: 10.1016/j.jceh.2014.06.005
       
  • Pathogenesis of Hepatic Encephalopathy: Role of Ammonia and Systemic
           Inflammation
    • Authors: Dominic R. Aldridge; Edward J. Tranah, Debbie L. Shawcross
      Abstract: The syndrome we refer to as Hepatic Encephalopathy (HE) was first characterized by a team of Nobel Prize winning physiologists led by Pavlov and Nencki at the Imperial Institute of Experimental Medicine in Russia in the 1890's. This focused upon the key observation that performing a portocaval shunt, which bypassed nitrogen-rich blood away from the liver, induced elevated blood and brain ammonia concentrations in association with profound neurobehavioral changes. There exists however a spectrum of metabolic encephalopathies attributable to a variety (or even absence) of liver hepatocellular dysfunctions and it is this spectrum rather than a single disease entity that has come to be defined as HE.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-06-30
      DOI: 10.1016/j.jceh.2014.06.004
       
  • Hepatic Encephalopathy and Sleepiness: An Interesting Connection'
    • Authors: Sara Montagnese; Matteo Turco, Piero Amodio
      Abstract: Sleep-wake abnormalities in patients with cirrhosis have been traditionally associated with hepatic encephalopathy (HE). In recent years, a certain amount of work has been devoted to the study of this relationship. This has lead to a modified picture, with weakening of the association between HE and poor night sleep, and the emergence of stronger links between HE and excessive daytime sleepiness. This brief review focuses on the evidence in favor of the interpretation of HE as a sleepiness syndrome, and on the diagnostic, therapeutic and social implications of such an interpretation.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-06-29
      DOI: 10.1016/j.jceh.2014.06.006
       
  • A Tribute to a Dear Colleague
    • Authors: Roger F. Butterworth
      Abstract: It was with great sadness that we learned that Joan (Juan) Cordoba, a dear colleague and friend had passed away. Born in Barcelona, Juan was quintessentially Spanish and a proud Catalan. He was the eldest of five children. Armed with his MD degree (cum laude in all subjects) from The University of Barcelona in 1987, Juan trained with the best on both sides of the Atlantic but it was the time he spent with Dr Andy Blei at North Western University in Chicago that fostered what was to become a career-long interest in hepatic encephalopathy (HE).
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-06-20
      DOI: 10.1016/j.jceh.2014.05.001
       
  • Approach to Clinical Syndrome of Jaundice and Encephalopathy in Tropics
    • Authors: Anil C. Anand; Hitendra K. Garg
      Abstract: A large number of patients present with jaundice and encephalopathy in tropical country like India and acute liver failure is the usual cause. Clinical presentation like ALF is also a complication of many tropical infections, and these conditions may mimic ALF but may have subtle differences from ALF. Moreover, what hepatologists see as acute liver failure in tropics is different from what is commonly described in Western Textbooks. Paracetamol overdose, which is possibly the commonest cause of ALF in UK and USA, is hardly ever seen in India.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-06-07
      DOI: 10.1016/j.jceh.2014.05.007
       
  • Management of Overt Hepatic Encephalopathy
    • Authors: Praveen Sharma; Barjesh C. Sharma
      Abstract: Hepatic encephalopathy (HE) is an important complication of cirrhosis with significant morbidity and mortality. Management of HE primarily involves avoidance of precipitating factors and administration of various ammonia-lowering therapies such as non-absorbable disaccharides, antimicrobial agents like rifaximin and l-ornithine l-aspartate. The non-absorbable disaccharides which include lactulose and lactitol are considered the first-line therapy for the treatment of HE and in primary and secondary prophylaxis of HE.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-05-08
      DOI: 10.1016/j.jceh.2014.04.004
       
  • Decellularization and Cell Seeding of Whole Liver Biologic Scaffolds
           Composed of Extracellular Matrix
    • Authors: Denver M. Faulk; Justin D. Wildemann, Stephen F. Badylak
      Abstract: The definitive treatment for patients with end-stage liver disease is orthotropic transplantation. However, this option is limited by the disparity between the number of patients needing transplantation and the number of available livers. This issue is becoming more severe as the population ages and as the number of new cases of end-stage liver failure increases. Patients fortunate enough to receive a transplant are required to receive immunosuppressive therapy and must live with the associated morbidity.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-03-31
      DOI: 10.1016/j.jceh.2014.03.043
       
  • Management of Covert Hepatic Encephalopathy
    • Authors: Abhijeet Waghray; Nisheet Waghray, Kevin Mullen
      Abstract: Hepatic encephalopathy is a reversible progressive neuropsychiatric disorder that encompasses a wide clinical spectrum. Covert hepatic encephalopathy is defined as patients with minimal hepatic encephalopathy and Grade I encephalopathy by West-Haven Criteria. Terminology such as “sub-clinical”, “latent”, and “minimal” appear to trivialize the disease and have been replaced by the term covert. The lack of clinical signs means that covert hepatic encephalopathy is rarely recognized or treated outside of clinical trials with options for therapy based on patients with episodic hepatic encephalopathy.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-02-27
      DOI: 10.1016/j.jceh.2014.02.007
       
  • Pathogenesis of Hepatic Encephalopathy and Brain Edema in Acute Liver
           Failure
    • Authors: Roger F. Butterworth
      Abstract: Neuropathologic investigations in acute liver failure (ALF) reveal significant alterations to neuroglia consisting of swelling of astrocytes leading to cytotoxic brain edema and intracranial hypertension as well as activation of microglia indicative of a central neuroinflammatory response. Increased arterial ammonia concentrations in patients with ALF are predictors of patients at risk for the development of brain herniation. Molecular and spectroscopic techniques in ALF reveal alterations in expression of an array of genes coding for neuroglial proteins involved in cell volume regulation and mitochondrial function as well as in the transport of neurotransmitter amino acids and in the synthesis of pro-inflammatory cytokines.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-02-14
      DOI: 10.1016/j.jceh.2014.02.004
       
  • Macrophages from Patients with Cirrhotic Ascites Showed Function
           Alteration of Host Defense Receptor
    • Authors: Abdel Motaal M. Ahmed; Abdel Gadir Y. Kadaru, Ibtihal Omer, Ahmed M. Musa, Khalid Enan, Isam M. El Khidir, Roger Williams
      First page: 279
      Abstract: Patients with cirrhotic ascites (PCA) are susceptible to spontaneous bacterial peritonitis (SBP) which has increased morbidity and mortality. Since some host defense aspects of peritoneal macrophages (PMф) from PCA are altered this study examined factors related to receptor-mediated phagocytosis.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-17
      DOI: 10.1016/j.jceh.2014.08.003
       
  • Sustained Virological Response Rates to Antiviral Therapy in Genotype 1
           and 3 Chronic Hepatitis C Patients: A Study from North India
    • Authors: Varun Gupta; Ashish Kumar, Praveen Sharma, Pankaj Tyagi, Naresh Bansal, Vikas Singla, Anil Arora
      First page: 287
      Abstract: In India, both genotype 3 and 1 are predominant genotypes in patients with chronic hepatitis C (CHC). However, there is scanty data on sustained viral response (SVR) rate with conventionally recommended dual therapy with PEG-IFN and ribavirin.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-15
      DOI: 10.1016/j.jceh.2014.08.004
       
  • Protective Effects of Norursodeoxycholic Acid Versus Ursodeoxycholic Acid
           on Thioacetamide-induced Rat Liver Fibrosis
    • Authors: Vyacheslav U. Buko; Oxana Y. Lukivskaya, Elena E. Naruta, Elena B. Belonovskaya, Horst-Dietmar Tauschel
      First page: 293
      Abstract: Effects of norursodeoxycholic acid (norUDCA) and ursodeoxycholic acid (UDCA) on liver fibrosis progression and liver fibrosis reversal in thioacetamide (TAA)-treated rats were studied.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-02-10
      DOI: 10.1016/j.jceh.2014.02.001
       
  • Role of Human Albumin in the Management of Complications of Liver
           Cirrhosis
    • Authors: Mauro Bernardi; Carmen S. Ricci, Giacomo Zaccherini
      First page: 302
      Abstract: Albumin is a negatively charged, relatively small protein synthesized by liver cells. Is the most abundant protein in extracellular fluid and accounts for about 70% of the plasma colloid osmotic pressure. Therefore it plays a crucial role in regulating fluid distribution in the body. In addition, albumin possesses functional domains with important non-oncotic properties, such as potent anti-oxydant and scavenging activities, binding of highly toxic reactive metal species and a great amount of endogenous and exogenous substances.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-20
      DOI: 10.1016/j.jceh.2014.08.007
       
  • Tackling the Hepatitis B Disease Burden in India
    • Authors: Pankaj Puri
      First page: 312
      Abstract: Globally, approximately 240 people have been infected worldwide with hepatitis B Virus (HBV). India has approximately HBV carrier rate of 3.0% with a high prevalence rate in the tribal population. With a population of more than 1.25 billion, India has more than 37 million HBV carriers and contributes a large proportion of this HBV burden. While horizontal transmission in childhood appears to be a major route of transmission, the role of vertical transmission is probably underestimated. Blood transfusion and unsafe therapeutic injections continue to be important modes of transmission of HBV.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-22
      DOI: 10.1016/j.jceh.2014.12.004
       
  • Sinusoidal Obstruction Syndrome (Hepatic Veno-Occlusive Disease)
    • Authors: Cathy Q. Fan; James M. Crawford
      First page: 332
      Abstract: Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal hepatic venules, which in its more severe forms imparts a high risk of mortality. SOS, also known as veno-occlusive disease (VOD), occurs as a result of cytoreductive therapy prior to hematopoietic stem cell transplantation (HSCT), following oxaliplatin-containing adjuvant or neoadjuvant chemotherapy for colorectal carcinoma metastatic to the liver and treated by partial hepatectomy, in patients taking pyrrolizidine alkaloid-containing herbal remedies, and in other particular settings such as the autosomal recessive condition of veno-occlusive disease with immunodeficiency (VODI).
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-11-13
       
  • Infections After Orthotopic Liver Transplantation
    • Authors: Mark Pedersen; Anil Seetharam
      First page: 347
      Abstract: Opportunistic infections are a leading cause of morbidity and mortality after orthotopic liver transplantation. Systemic immunosuppression renders the liver recipient susceptible to de novo infection with bacteria, viruses and fungi post-transplantation as well to reactivation of pre-existing, latent disease. Pathogens are also transmissible via the donor organ. The time from transplantation and degree of immunosuppression may guide the differential diagnosis of potential infectious agents. However, typical systemic signs and symptoms of infection are often absent or blunted after transplant and a high index of suspicion is needed.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-07-24
      DOI: 10.1016/j.jceh.2014.07.004
       
  • Wild Mushroom Poisoning in North India: Case Series with Review of
           Literature
    • Authors: Nipun Verma; Ashish Bhalla, Susheel Kumar, Radha K. Dhiman, Yogesh K. Chawla
      First page: 361
      Abstract: Mushroom is an important constituent of diet in many ethnic tribes in India. Ethnic Indian tribes are known to consume nearly 283 species of wild mushrooms out of 2000 species recorded world over. Although they are experts in distinguishing the poisonous from edible mushrooms, yet occasional cases of toxicity are reported due to accidental consumption of poisonous mushrooms. We report amanita like toxicity in a family after consumption of wild mushrooms resulting in fatal outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-25
      DOI: 10.1016/j.jceh.2014.09.004
       
  • Hydatid Cyst of Liver Presented as Obstructive Jaundice in Pregnancy;
           Managed by PAIR: Report of a Common Procedure in a Rare Setting from India
           
    • Authors: Jayant K. Ghosh; Sundeep K. Goyal, Manas K. Behera, Vinod K. Dixit, Ashok K. Jain
      First page: 366
      Abstract: Incidence of Hydatid disease in pregnancy ranges from 1in 20,000 to 1 in 30,000. The most common site of hydatid cysts is the liver. The diagnosis of liver hydatid cysts is not difficult but the management during pregnancy is problematic. Both medical and surgical treatments are available but there is no consensus and each case has to be individualized. We present a case of liver hydatid cyst presented with obstructive jaundice during pregnancy which was managed by Puncture of the cyst under USG guidance; Aspiration of the cystic fluid, Injection of hypertonic saline, and Re-aspiration of solution without drainage (PAIR) and albendazole therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-06
      DOI: 10.1016/j.jceh.2014.11.002
       
  • An Elderly Man with a Huge Liver
    • Authors: Vishal Sharma; Abhinav Aggarwal, Ritesh Singla, Naveen Kalra, Yogesh K. Chawla
      First page: 370
      Abstract: A 71-year old male presented with generalised gradual onset abdominal distension for 15 days accompanied by abdominal discomfort without any history of loss of appetite or weight. He was a chronic tobacco chewer and a non-alcoholic. Systemic examination revealed a nodular firm liver and presence of ascites but no splenomegaly. Rest of his systemic examination was normal. His liver function tests were deranged with total bilirubin: 1.6 mg/dL (normal, 0.3–1.0 mg/dL), alanine transaminase: 74.8 (Normal, 2–45 IU/L), aspartate transaminase: 90.7 (Normal, 2–35 IU/L), serum alkaline phosphatase: 868 (Normal, 42–128 IU/L) and serum albumin 3.1 mg/dL (normal, 3.5–5 mg/dL).
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-12
      DOI: 10.1016/j.jceh.2014.12.001
       
  • Potential Newer Therapeutic Targets for Hepatitis B Virus Drug Development
    • Authors: Shalimar
      First page: 371
      Abstract: Christian Königera,b, Ida Wingerta, Moritz Marsmanna, Christine Röslera, Jürgen Becka,, and Michael Nassala. Involvement of the host DNA repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4244–53.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-06
      DOI: 10.1016/j.jceh.2014.11.001
       
  • Hepatobiliary Quiz–12 (2014)
    • Authors: Swastik Agrawal; Radha K. Dhiman
      First page: 374
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-10
      DOI: 10.1016/j.jceh.2014.11.003
       
  • Hepatobiliary Quiz–12 (2014)
    • Authors: Swastik Agrawal; Radha K. Dhiman
      First page: 376
      Abstract: Idiopathic non-cirrhotic intrahepatic portal hypertension (NCIPH) has been described by various terminologies such as idiopathic portal hypertension, non-cirrhotic portal fibrosis (NCPF), nodular regenerative hyperplasia (NRH), incomplete septal cirrhosis, partial nodular transformation of the liver, benign intrahepatic portal hypertension and hepatoportal sclerosis. Although, these diseases differ in some details in their description and defining criteria, they are believed to represent variations in appearance of a single pathological entity.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-11
      DOI: 10.1016/j.jceh.2014.11.004
       
  • Giant Hemangioma Causing Budd-Chiari Syndrome
    • Authors: Vishal Sharma; Abhinav Aggarwal, Ritesh Singla, Naveen Kalra, Yogesh K. Chawla
      First page: 380
      Abstract: Triphasic CT scan of abdomen showed diffuse, large heterogeneous area involving left lobe and anterior segments of right lobe of liver with multiple similar character lesions in posterior segment with centripetal filling suggestive of liver hemangiomatosis (Figure 1A, B and C). The giant hemangioma was seen causing mass effect in form of compression of right hepatic vein and non-visualization of middle and left hepatic veins with chinking of intrahepatic inferior vena cava consistent with Budd-Chiari syndrome (Figure 1B).
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-12-12
      DOI: 10.1016/j.jceh.2014.12.002
       
  • Magnetic Resonance Imaging and Spectroscopy in Hepatic Encephalopathy
    • Authors: Laia Chavarria; Juan Cordoba
      Abstract: Hepatic encephalopathy is a brain alteration associated to liver failure that produces cognitive impairments at long term. Neuroimaging are non-invasive methods for the study of the brain by means of spectroscopy and imaging techniques. These technologies give huge information about cerebral metabolism and water distribution to explore brain pathways involved in the pathogenesis of hepatic encephalopathy. Furthermore, new magnetic resonance implementations such as voxel-based morphometry or resting-state functional magnetic resonance imaging allow studying brain atrophy and neuronal connectivity of the cerebral network involved in the neurocognitive impairments observed in the patients.
      Citation: Journal of Clinical and Experimental Hepatology (2013)
      PubDate: 2013-10-28
       
  • Portal Vein Thrombosis in Cirrhosis
    • Authors: Kaiser Raja; Mathew Jacob, Sonal Asthana
      First page: 320
      Abstract: Portal vein thrombosis (PVT) is being increasingly recognized in patients with advanced cirrhosis and in those undergoing liver transplantation. Reduced flow in the portal vein is probably responsible for clotting in the spleno-porto-mesenteric venous system. There is also increasing evidence that hypercoagulability occurs in advanced liver disease and contributes to the risk of PVT. Ultrasound based studies have reported a prevalence of PVT in 10–25% of cirrhotic patients without hepatocellular carcinoma.
      Citation: Journal of Clinical and Experimental Hepatology (2013)
      PubDate: 2013-12-09
      DOI: 10.1016/j.jceh.2013.12.003
       
 
 
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