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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.283]   [H-I: 7]   [3 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [3031 journals]
  • Cholemic or Bile Cast Nephropathy in a Child with Liver Failure
    • Authors: Vikrant Sood; Bikrant B. Lal, Suman Lata, Archana Rastogi, Seema Alam
      Abstract: Cholemic or bile cast nephropathy is an under-reported entity characterized by acute renal dysfunction in patients with hepatic insult. Limited literature is available regarding its clinical presentation, pathogenesis and prognosis. We hereby present a pediatric case who presented with acute on chronic liver failure with renal dysfunction secondary to cholemic nephropathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-24
      DOI: 10.1016/j.jceh.2017.05.006
  • Glycochenodeoxycholic Acid Does Not Increase Transforming Growth
           Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis
           in Myofibroblasts
    • Authors: Anna Wang; Dorothy Yu, Yuewen Gong, Jessie Garber, Gerald Y. Minuk
      Abstract: Primary sclerosing cholangitis (PSC) is a chronic, progressive hepatobiliary disorder characterized by extensive fibrosis and stricturing of the intra- and/or extra-hepatic bile ducts: Previous studies have documented low phosphatylcholine (PC) concentrations in PSC bile. The aim of this study was to determine whether low PC levels in bile facilitate toxic bile acid induced injury of biliary tract epithelial cells resulting in enhanced transforming growth factor-beta (TGF-β) expression and increased collagen synthesis by myofibroblasts.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.04.002
  • An Insight into Antibiotic Resistance to Bacterial Infection in Chronic
           Liver Disease
    • Authors: Mayank Jain; Joy Varghese, Tom Michael, Chandan Kumar Kedarishetty, Balajee G, Subramanian Swaminathan, Jayanthi Venkataraman
      Abstract: End stage liver disease leads to immune dysfunction which predisposes to infection. There has been a rise in antibiotic resistant infections in these patients. There is scanty data f from India or idea regarding the same.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.003
  • In Situ Splitting of the Cadaver Liver for Two Adult Recipients by LDLT
    • Authors: Nilesh S. Patil; Neerav Goyal, Shishir Pareek, Mohammed Nayeem, Subhash Gupta
      Abstract: To expand the donor pool, split liver transplantation is conventionally performed for one adult and one pediatric recipient. Application of this technique for two adult recipients can produce remarkable impact on the waiting list. Proper donor and recipient selection is crucial for the favorable outcome following full-right and full-left liver split. Right lobe adult to adult living donor liver transplantation (LDLT) is essentially a full right and full left split. However, LDLT techniques have not been used for full right and left split.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.001
  • Hemophagocytic Lymphohistiocytosis Masquerading as Acute Liver Failure: A
           Single Center Experience
    • Authors: Nitin Jagtap; Mithun Sharma, Gupta Rajesh, Padaki Nagaraja Rao, Sekaran Anuradha, Manu Tandan, Mohan Ramchandani, Duvvuru Nageshwar Reddy
      Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disorder of extreme inflammation and unregulated immune response which require prompt recognition and early introduction of definitive therapy. HLH can present with wide range of hepatic dysfunction ranging from mild elevation of transaminases to liver failure. This study is carried out to describe the clinical and laboratory presentation of HLH.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-15
      DOI: 10.1016/j.jceh.2017.01.119
  • Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases
    • Authors: Narendra S. Choudhary; Vijay Bodh, Shraddha Chaudhari, Neeraj Saraf, Sanjiv Saigal
      Abstract: Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-02
      DOI: 10.1016/j.jceh.2017.01.001
  • Results of Portosystemic Shunt Embolization in Selected Patients with
           Cirrhosis and Recurrent Hepatic Encephalopathy
    • Authors: Narendra S. Choudhary; Sanjay Saran Baijal, Sanjiv Saigal, Amit Agarwal, Neeraj Saraf, Rohit Khandelwal, Vaibhav Jain, Anubhav Harish Khandelwal, Abhay Kapoor, Deepak Jain, Smurti R. Misra, Rajesh Puri, Randhir Sud, Arvinder S. Soin
      Abstract: Large portosystemic shunts (PSSs) may lead to recurrent encephalopathy in patients with cirrhosis and embolization of these shunts may improve encephalopathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-27
      DOI: 10.1016/j.jceh.2017.03.012
  • Characterization of Cerebral Edema in Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Chirag K. Ahuja, Swastik Agrawal, Madhu Chopra, Naveen Kalra, Ajay Duseja, Sunil Taneja, Niranjan Khandelwal, Yogesh Chawla
      Abstract: The nature of cerebral edema in acute-on-chronic liver failure (ACLF) is not well studied. We aimed to characterize cerebral edema in ACLF using magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-25
      DOI: 10.1016/j.jceh.2017.04.001
  • Brain Microstructural Correlates of Cognitive Dysfunction in Clinically
           and Biochemically Normal Hepatitis C Virus Infection
    • Authors: Ajay Kumar; Amar Deep, Rakesh K. Gupta, Virendra Atam, Samir Mohindra
      Abstract: This study examined correlates of the brain's neurocognitive performance among clinically and biochemically normal adult patient with hepatitis C virus (HCV). We hypothesized that anti-HCV positive individuals would demonstrate structural brain abnormalities and neurocognitive dysfunction as well as the changes in cell component and extracellular space in the white matter regions of brain in asymptomatic HCV infection by using diffusion tensor tractrography (DTT) metrics.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-24
      DOI: 10.1016/j.jceh.2017.03.011
  • Thromboelastography for Assessing the Risk of Bleeding in Patients With
           Cirrhosis—Moving Closer
    • Authors: Vaibhav Somani; Deepak Amarapurkar, Apurva Shah
      Abstract: Conventional coagulation tests (CCTs) in patients with cirrhosis only assess procoagulant factors and are poor predictors of bleeding risk. In spite of this knowledge, they are routinely used prior to invasive procedures, and attempts are made to correct these abnormalities before invasive procedures. These practices are not supported by the evidence and are harmful to the patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-21
      DOI: 10.1016/j.jceh.2017.03.001
  • Role of Human Wharton's Jelly Derived Mesenchymal Stem Cells (WJ-MSCs) for
           Rescue of d-Galactosamine Induced Acute Liver Injury in Mice
    • Authors: Raghu Ramanathan; Secunda Rupert, Sakthivel Selvaraj, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
      Abstract: Mesenchymal stem cells (MSCs) are multipotent precursor cells having self-renewal ability making them a candidate for use in regenerative medicine. Acute liver injury results in sudden loss of hepatic function leading to organ failure. Liver transplantation is often required to salvage patients with acute liver failure. Due to shortage of organs, identification of alternate method is the need of the hour. In view of this, an attempt has been made to check the regenerative ability of WJ-MSCs (wharton's jelly derived MSC) in mice models for acute liver injury.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-20
      DOI: 10.1016/j.jceh.2017.03.010
  • Transient Elastography (Fibroscan) in Patients with Non-cirrhotic Portal
    • Authors: Praveen Sharma; Rachit Agarwal, Shashi Dhawan, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      Abstract: Non-cirrhotic portal hypertension (NCPH) is a common cause of variceal bleed in developing countries. Transient elastography (TE) using Fibroscan is a useful technique for evaluation of fibrosis in patients with liver disease. There is a paucity of studies evaluating TE in patients with Non-cirrhotic portal fibrosis (NCPF) and none in Asian population. Aim of this study was to evaluate role of TE in NCPF.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-04
      DOI: 10.1016/j.jceh.2017.03.002
  • Comparative Study of Community Acquired and Nosocomial Spontaneous
           Bacterial Peritonitis and its Variants in 150 Patients
    • Authors: Girisha Balaraju; Mallikarjun Patil, Adarsh C. Krishnamurthy, Dheeraj Karanth, Harshad Devarbhavi
      Abstract: Nosocomial acquisition of spontaneous bacterial peritonitis (SBP) is debated as having a different microbial etiology and prognosis. Identification of clinical, laboratory predictors of mortality and appropriate empirical antimicrobial selection is necessary to prevent early mortality and morbidity. We aimed to find the clinical and bacteriological profile in nosocomial and community acquired SBP and its variants, and the predictors of mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-03
      DOI: 10.1016/j.jceh.2017.03.005
  • Comparison of Contrast Enhanced Ultrasound With Contrast Enhanced Computed
           Tomography for the Diagnosis of Hepatocellular Carcinoma
    • Authors: Sandeep Moudgil; Naveen Kalra, Nidhi Prabhakar, Radha Krishan Dhiman, Arunanshu Behera, Yogesh Kumar Chawla, Niranjan Khandelwal
      Abstract: The most common primary malignant tumor of liver is hepatocellular carcinoma (HCC). The highest risk of developing HCC is seen in patients of cirrhosis. Ultrasound is used for surveillance in these patients. This study evaluates the role of contrast enhanced ultrasound (CEUS) in the diagnosis of HCC and compares CEUS to contrast enhanced computed tomography (CECT).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-29
      DOI: 10.1016/j.jceh.2017.03.003
  • Efficacy and Safety of Sofosbuvir-Based Direct Acting Antivirals for
           Hepatitis C in Septuagenarians and Octogenarians
    • Authors: Heather S. Snyder; Bilal Ali, Humberto C. Gonzalez, Satheesh Nair, Sanjaya K. Satapathy
      Abstract: Treatment of chronic hepatitis C (HCV) with newer direct acting antiviral (DAA) agents has been highly effective. Unfortunately, patients over 70 years old are underrepresented in studies. Given current recommendations to screen patients born between 1945 and 1965 for HCV, it is essential to determine the efficacy and safety of DAAs within the elderly population. This study aims to evaluate clinical outcomes of patients aged 70 years or older treated for HCV with DAAs at a single tertiary care center.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-28
      DOI: 10.1016/j.jceh.2017.03.009
  • Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron
           Overload Syndrome
    • Authors: Gyanendra K. Acharya; Hung-I Liao, Simona Frunza-Stefan, Ronakkumar Patel, Moe Khaing
      Abstract: Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-28
      DOI: 10.1016/j.jceh.2017.03.006
  • The Plasma and Serum Metabotyping of Hepatocellular Carcinoma in a
           Nigerian and Egyptian Cohort using Proton Nuclear Magnetic Resonance
    • Authors: Mohamed I.F. Shariff; Jin Un Kim, Nimzing G. Ladep, Asmaa I. Gomaa, Mary M.E. Crossey, Edith Okeke, Edmund Banwat, Imam Waked, I. Jane Cox, Roger Williams, Elaine Holmes, Simon D. Taylor-Robinson
      Abstract: Previous studies have observed disturbances in the 1H nuclear magnetic resonance (NMR) blood spectral profiles in malignancy. No study has metabotyped serum or plasma of hepatocellular carcinoma (HCC) patients from two diverse populations. We aimed to delineate the HCC patient metabotype from Nigeria (mostly hepatitis B virus infected) and Egypt (mostly hepatitis C virus infected) to explore lipid and energy metabolite alterations that may be independent of disease aetiology, diet and environment.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-27
      DOI: 10.1016/j.jceh.2017.03.007
  • Fas Receptor Activation by Endogenous Opioids Is A New Mechanism for
           Cardiomyopathy in Cirrhotic Rats
    • Authors: Ata Abbasi; Negar Faramarzi, Mohsen Khosravi, Fatemeh Yazarloo, Mohammad Amin Abbasi, Ahmad R. Dehpour, Issa Jahanzad
      Abstract: Cirrhosis, a common consequence of chronic liver inflammation is associated with various cardiovascular dysfunctions which are called cirrhotic cardiomyopathy (CC). Among the various possible causes of CC, apoptosis is considered to have a pivotal role.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-27
  • A Rare Case of Primary Sarcomatous Hepatocellular Carcinoma Without
           Previous Anticancer Therapy
    • Authors: Suvradeep Mitra; Saumya Gupta, Divya Dahiya, Uma N. Saikia
      Abstract: Primary sarcomatous hepatocellular carcinoma (PSHCC) is a rare and aggressive variety of hepatocellular carcinoma (HCC). The recent evidence suggests that anticancer therapy promotes the dedifferentiation of the carcinomatous component and is largely responsible for this aggressive variant of HCC. However, in the absence of any anticancer therapy, occurrence of PSHCC is extremely rare. Herein, we present a rare case report of a 65 year old male patient, with a hepatitis B positive status, presenting with PSHCC without any history of anticancer therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-24
      DOI: 10.1016/j.jceh.2017.03.008
  • A Dynamic Definition of Acute Kidney Injury Does not Improve Prognosis
           Assessment in Acutely Decompensated Patients with Cirrhosis
    • Authors: Sebastián Marciano; Ezequiel Mauro, Melisa Dirchwolf, María Emilia Debernardi, Diego Giunta, Vanina Pagotto, Liliana Rojas, Adrián Gadano
      Abstract: to compare the prognostic accuracy for 28 and 90-day transplant-free mortality of a modified CLIF-SOFA score (including a dynamic definition of acute kidney injury) with that of the classic CLIF-SOFA score and KDIGO score for acute kidney injury in patients with acute decompensation of cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-24
      DOI: 10.1016/j.jceh.2017.03.004
  • Gastric Varices in Cirrhosis vs. Extrahepatic Portal Venous Obstruction
           and Response to Endoscopic N-butyl-2-cyanoacrylate Injection
    • Authors: Barjesh C. Sharma; Shivakumar Varakanahalli, Jatinder P. Singh, Siddharth Srivastava
      Abstract: Gastric varices (GV) are found in patients with portal hypertension. Incidence of bleeding from GV is relatively low, but is severe, and associated with higher mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-03
      DOI: 10.1016/j.jceh.2016.09.002
  • Patulin Induced Oxidative Stress Mediated Apoptotic Damage in Mice, and
           its Modulation by Green Tea Leaves (GTL)
    • Authors: Girindrababu Venkattappa Jayashree; Krishnaswamy Krupashree, Puttasiddiah Rachitha, Farhath Khanum
      Abstract: The present study demonstrates the antioxidant and hepatic protective effects of Green tea leaves (GTL).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-26
      DOI: 10.1016/j.jceh.2017.01.113
  • Is Portal Venous Pressure Or Porto Systemic Gradient Really A Harbinger of
           Poor Outcomes After Living Donor Liver Transplantation'
    • Authors: Amol Vijay Kanetkar; Dinesh Balakrishnan, Sudhindran Sudhindran, Puneet Dhar, Unnikrishnan Gopalakrishnan, Ramachandran Menon, Othiyil Vayoth Sudheer
      Abstract: Portal hyperperfusion as a cause of small for size syndrome (SFSS) after living donor liver transplantation (LDLT) remains controversial. Portal venous pressure (PVP) is often measured indirectly and may be confounded by central venous pressure (CVP).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-21
      DOI: 10.1016/j.jceh.2017.01.114
  • Spontaneous Bacterial Peritonitis by Burkholderia cepacia Complex: A Rare,
           Difficult to Treat Infection in Decompensated Cirrhotic Patients
    • Authors: Sunil Taneja; Pramod Kumar, Vikas Gautam, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Yogesh Chawla
      Abstract: Burkholderia cepacia complex (Bcc) is non-fermenting Gram-negative bacillus and has been rarely reported to cause spontaneous bacterial peritonitis (SBP) in decompensated cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-18
      DOI: 10.1016/j.jceh.2016.08.008
  • Can Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease
    • Authors: Manu Mehta; Sandeep Satsangi, Ajay Duseja, Sunil Taneja, Radha K. Dhiman, Yogesh Chawla
      Abstract: Nonalcoholic fatty liver disease (NAFLD) by definition would require exclusion of significant alcohol intake. Present study was aimed to assess the prevalence of various components of metabolic syndrome (MS) in patients with alcoholic cirrhosis (AC) and to study the affect of its presence on the severity of liver disease, testing the hypothesis if alcoholic liver disease (ALD) and NAFLD could co-exist.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-18
      DOI: 10.1016/j.jceh.2017.01.112
  • Liver Function Tests Abnormalities and Hepatitis B Virus & Hepatitis C
           Virus Co-infection in Human Immunodeficiency Virus (HIV)-infected Patients
           in India
    • Authors: P. Puri; P.K. Sharma, A. Lolusare, V.K. Sashindran, S. Shrivastava, A.K. Nagpal
      First page: 1
      Abstract: While highly active anti-retroviral therapy (HAART) has improved survival of HIV-infected patients, there is increasing liver disease and progressive Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) related liver disease.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-01-09
      DOI: 10.1016/j.jceh.2016.12.002
  • 2D Shear Wave Elastography of Liver in Patients with Primary Extrahepatic
           Portal Vein Obstruction
    • Authors: Kumble S. Madhusudhan; Raju Sharma, Ragini Kilambi, Sudhin Shylendran, Shalimar, Peush Sahni, Arun K. Gupta
      First page: 23
      Abstract: To evaluate liver stiffness (LS) in patients of primary extrahepatic portal vein obstruction (EHPVO) using 2D shear wave elastography (SWE) and compare it with healthy volunteers.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-01-05
      DOI: 10.1016/j.jceh.2016.12.001
  • Potential Liver Transplant Recipients with Hepatitis C: Should They Be
           Treated Before or After Transplantation'
    • Authors: Anil C. Anand
      First page: 42
      Abstract: Treatment of hepatitis C virus (HCV) with newer directly acting antivirals (DAAs) and lead to sustained viral response (SVR) in majority of patients and SVR has been documented to be associated with reversal of liver cirrhosis. The improved SVR rates and safety profiles of DAAs have led to the treatment of patients with decompensated cirrhosis awaiting liver transplantation (LT). Several clinical trials of DAAs in decompensated HCV patients have recently demonstrated SVR rates above 80%, which have been associated with significant improvements, in the Child–Pugh–Turcotte scores/or model for end-stage liver disease scores in a proportion of patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-22
      DOI: 10.1016/j.jceh.2017.01.116
  • Role of Allopurinol in Optimizing Thiopurine Therapy in Patients with
           Autoimmune Hepatitis: A Review
    • Authors: Shivani Deswal; Anshu Srivastava
      First page: 55
      Abstract: Autoimmune hepatitis (AIH) is a chronic immune mediated liver disease characterized by elevated transaminases, hyper gammaglobulinemia, presence of autoantibodies and interface hepatitis in the absence of a known etiology of liver disease. Thiopurines (azathioprine [AZA]/6-mercaptopurine [6MP]) and steroids remain the first line of treatment of AIH in both children and adults. However, a small proportion of AIH patients are either non-responders or develop side effects with AZA. The metabolism of AZA is complex and mediated by multiple enzymes.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-21
      DOI: 10.1016/j.jceh.2017.01.115
  • Synchronous Gall Bladder and Bile Duct Cancer: A Short Series of Seven
           Cases and a Brief Review of Literature
    • Authors: Harshal Rajekar
      Abstract: Simultaneous presence of cancer in the gall bladder and in the biliary tree could be due to local spread, metastases, de novo multifocal origin, or as part of a field change. In the past, such an association has been described in patients with anomalous pancreatico-biliary ductal junction.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-12-02
  • Epigastric Pain in a Patient with Cirrhosis
    • Authors: Ying C. Lee; Yi C. Yeh, Yi Y. Chiou, Chieu A. Liu, Nai C. Chiu
      Abstract: An 83-year-old man with past history of hepatitis C presented with acute onset epigastric pain for 3 days. He was diagnosed with liver cirrhosis mainly by images study, and had not received treatment for hepatitis. Laboratory analysis revealed mild hypoalbuminemia (3.5g/dL) with no other abnormalities. Dynamic computed tomography was performed, showing a heterogeneous soft tissue mass in left hepatic lobe, arterial enhancement (Figure 1, arrow) and venous phase washout (Figure 2, arrow), with linear patchy calcification at the sigmoid colonic wall (Figure 3, arrow).
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-17
      DOI: 10.1016/j.jceh.2016.09.017
  • Living Donor Liver Transplantation for Acute Liver Failure With Fixed
           Pupils: Are We Fixed'
    • Authors: Shweta A. Singh; Anshuman Singh, Viniyendra Pamecha, Chandra Kant Pandey, Shiv Kumar Sarin
      Abstract: Living donor liver transplantation (LDLT) is fraught with the social and ethical dilemma of excising a part of the liver from a healthy first-degree relative. When LDLT is to be done for an acute liver failure (ALF), identification of a suitable donor is a race against time. Herein, we describe a unique challenge faced by the transplant team of whether to proceed with donor hepatectomy from a son, when the recipient (HBV-related ALF) developed non-reactive fully dilated pupils on the table, prior to beginning the surgery.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-02
      DOI: 10.1016/j.jceh.2016.09.014
  • Hepatitis E Virus Induced Acute Liver Failure with Scrub Typhus
           Coinfection in a Pregnant Woman
    • Authors: Nipun Verma; Megha Sharma, Manisha Biswal, Sunil Taneja, Nitya Batra, Abhay Kumar, Radha K. Dhiman
      Abstract: Coinfections contribute significantly to diagnostic challenges of acute febrile illnesses, especially in endemic areas. The confusion caused by overlapping clinical features impedes timely management. Herein, we report an unusual, previously unreported case of a pregnant woman suffering from a coinfection of scrub typhus and hepatitis E virus. A 25-year-old, 31-week pregnant woman presented with jaundice for 5 days and altered sensorium for 2 days. She had features of both viral acute liver failure (ALF) and tropical infections mimicking ALF, including hyperbilirubinemia, coagulopathy, anemia, thrombocytopenia, intravascular hemolysis, and hepatosplenomegaly.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-01
      DOI: 10.1016/j.jceh.2016.09.015
  • Hepatocellular Carcinoma: An Unusual Complication of Longstanding Wilson
    • Authors: Deepak Gunjan; Shalimar, Neeti Nadda, Saurabh Kedia, Baibaswata Nayak, Shashi B. Paul, Shivanand Ramachandra Gamanagatti, Subrat K. Acharya
      Abstract: Wilson disease is caused by the accumulation of copper in the liver, brain or other organs, due to the mutation in ATP7B gene, which encodes protein that helps in excretion of copper in the bile canaliculus. Clinical presentation varies from asymptomatic elevation of transaminases to cirrhosis with decompensation. Hepatocellular carcinoma is a known complication of cirrhosis, but a rare occurrence in Wilson disease. We present a case of neurological Wilson disease, who later developed decompensated cirrhosis and hepatocellular carcinoma.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-10-05
      DOI: 10.1016/j.jceh.2016.09.012
  • What is the Risk of Graft Reinfection in Case of Liver Transplantation for
           Patients With Acute HEV or HAV Infection'
    • Authors: Anil C. Anand; Neerav Goyal, Hitendra K. Garg, Shaleen K. Agarwal, Sudeep Khanna, Subhash Gupta
      Abstract: We are sharing the concerns expressed by some colleagues about the risk of graft reinfection in case of liver transplantation (LT) for patients with acute hepatitis E (HEV) or A (HAV) virus infection. It is well known that graft reinfection is nearly universal if LT is done for active hepatitis C virus (HCV) disease.1 Before the use of hepatitis B immunoglobulin (HBIG) and/or antiviral agents for prophylaxis, hepatitis B virus (HBV) re-infection occurred in more than 80% of patients resulting in dismal graft and patient survival.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-29
      DOI: 10.1016/j.jceh.2016.09.013
  • Impact of Hepatic and Extrahepatic Insults on the Outcome of
           Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Sahaj Rathi, Swastik Agrawal, Ajay Duseja, Sunil Taneja, Yogesh Chawla
      First page: 9
      Abstract: To study the differences in outcome and predictors of mortality in acute-on-chronic liver failure (ACLF) precipitated by hepatic or extrahepatic insults.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-16
  • Handgrip Strength as an Important Bed Side Tool to Assess Malnutrition in
           Patient with Liver Disease
    • Authors: Praveen Sharma; Abdul Rauf, Abdul Matin, Rachit Agarwal, Pankaj Tyagi, Anil Arora
      First page: 16
      Abstract: Malnutrition is frequently present in patients with cirrhosis. Anthropometric measures such as body mass index (BMI), mid arm muscle circumference (MAMC), triceps skin fold thickness (TST) and subjective global assessment (SGA) have some limitations in assessment of malnutrition. This study aims to determine the prevalence of malnutrition in non-hospitalized cirrhotic and chronic hepatitis patients and to assess handgrip (HG) strength as a tool for identifying malnutrition.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-10
  • Early Acute Severe HCV Recurrence After Transplantation: From Universal
           Mortality to Cure
    • Authors: Manav Wadhawan; Vivek Vij, Kausar Makki, Nalini Bansal, Ajay Kumar
      First page: 28
      Abstract: Acute severe recurrence of hepatitis C virus (HCV) after solid organ transplant is associated with high mortality. Pegylated interferon and ribavirin are suboptimal in treatment of this severe form of recurrence. We report 4 cases of acute severe HCV recurrence (within 6 months after transplant), including 3 cases with fibrosing cholestatic hepatitis treated with sofosbuvir and ribavirin. All four patients achieved a rapid suppression of HCV RNA with a normalization of liver function tests within 4 weeks of starting therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-11
  • The Preliminary Study on Procurement Biliary Convergence from Donors with
           Complicated Bile Duct Variant in Emergency Right Lobe Living Donor Liver
    • Authors: Sheng Ye; Jia-Hong Dong, Wei-Dong Duan, Wen-Bing Ji, Yu-Rong Liang
      First page: 33
      Abstract: The incidence of biliary complications after living donor adult liver transplantation (LDALT) is still high due to the bile duct variation and necessity reconstruction of multiple small bile ducts. The current surgical management of the biliary variants is unsatisfactory. We evaluated the role of a new surgical approach in a complicated hilar bile duct variant (Nakamura type IV and Nakamura type II) under emergent right lobe LDALT for high model for end-stage liver disease score patients.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-10-20
      DOI: 10.1016/j.jceh.2016.09.016
  • Portal Inflow in Extensive Portomesenteric Thrombosis: Using the
           Pericholedochal Varix in Living Donor Liver Transplantation
    • Authors: Kishore Gurumoorthy Subramanya Bharathy; Shridhar Vasantrao Sasturkar, Piyush Kumar Sinha, Senthil Kumar, Viniyendra Pamecha
      First page: 63
      Abstract: Extensive portomesenteric thrombosis presents a technical challenge in liver transplantation. Establishing portal inflow in living donor liver transplantation (LDLT) is indispensable to ensure regeneration of the graft. The use of a pericholedochal varix for inflow has been described only in a few case reports. Described herein is one such instance in the setting of LDLT, highlighting the nuances of this procedure in the light of available literature.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-11
  • Acute Onset Significant Muscle Weakness in a Patient Awaiting Liver
           Transplantation: Look for Statins
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Neeraj Saraf, Arvinder S. Soin
      First page: 66
      Abstract: Statins are commonly used drugs in patients with liver and cardiac disease. Statin-induced severe myopathy is a very uncommon presentation and rhabdomyolysis may occur in extreme cases which leads to renal failure. Patients with comorbidities like diabetes, hypothyroidism, and liver disease have higher chances of development of statin-induced myopathy. We describe a case of Child's C cirrhosis wherein the patient had acute onset significant muscle weakness and improved on statin discontinuation.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-28
      DOI: 10.1016/j.jceh.2016.09.007
  • Malignant Hepatic Epithelioid Hemangioendothelioma with Villaret Syndrome
    • Authors: Hanchanale Pavan; Joy Varghese, Kavya Harika, Mukul Vij, Venkataraman Jayanthi, Mohamed Rela
      First page: 68
      Abstract: Malignant hepatic epithelioid hemangioendothelioma is a rare, vascular tumor of the liver with peak incidence in the middle age with a female preponderance and of unknown etiology. Majority of the tumors are asymptomatic. The gold standard for diagnosis of the tumor is liver histology showing presence of epithelioid tumor cells on a background of a hyaline stroma. Immunohistochemical positivity for CD31, CD34, Factor VIII, and Podoplanin (D2-40) is confirmatory. The treatment of choice is liver transplantation.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-28
      DOI: 10.1016/j.jceh.2016.09.006
  • Giant Intrahepatic Portal Vein Aneurysm: Leave it or Treat it'
    • Authors: Amit Shrivastava; Jagdeesh S. Rampal, D. Nageshwar Reddy
      First page: 71
      Abstract: Portal vein aneurysm (PVA) is a rare vascular dilatation of the portal vein. It is a rare vascular anomaly representing less than 3% of all visceral aneurysms and is not well understood. Usually, PVA are incidental findings, are asymptomatic, and clinical symptoms are proportionally related to size. Patients present with nonspecific epigastric pain or gastrointestinal bleeding with underlying portal hypertension. PVA may be associated with various complications such as biliary tract compression, portal vein thrombosis/rupture, duodenal compression, gastrointestinal bleeding, and inferior vena cava obstruction.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-13
      DOI: 10.1016/j.jceh.2016.08.013
  • Unusual Presentation of Tubercular Liver Abscess in an Immune-Competent
    • Authors: Pramod Kumar; Sunil Taneja, Kirti Gupta, Ajay Duseja, Radha K. Dhiman, Yogesh K. Chawla
      First page: 77
      Abstract: Isolated hepatobiliary tuberculosis (TB) has been uncommonly described with or without biliary involvement and accounts for less than 1% of all tubercular infections. Isolated hepatic TB is even rare and poses a great diagnostic challenge. We report a case of isolated tubercular liver abscess with extension into the chest wall in an immune-competent adult, which was diagnosed and managed successfully with antitubercular treatment.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-27
      DOI: 10.1016/j.jceh.2016.09.011
  • Rapid Onset of Fatal Lactic Acidosis Complicating Tenofovir Therapy in a
           Diabetic Patient with Cirrhosis: A Cautionary Tale
    • Authors: Ramesh Kumar; Shivani Agrawal
      First page: 80
      Abstract: A nucleotide analogue (NA) has potential to cause mitochondrial (mt) toxicity which may lead to the development of lactic acidosis (LA).1 Tenofovir, a nucleotide analogue, induced LA is extremely rare because of its low affinity for mt DNA polymerase.2 We report a 45-year-old gentleman, with a background history of diabetes mellitus (DM) and hepatitis B virus related liver cirrhosis, who developed fatal LA after initiation of tenofovir. The patient had advanced cirrhosis with Model for End-stage Liver Disease score of 24, and he had not been on any anti-diabetic medication for 3 months.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-06
      DOI: 10.1016/j.jceh.2016.08.010
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