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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.283]   [H-I: 7]   [3 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [3039 journals]
  • The New INASL President: A Clinician par Excellence
    • Authors: Ashish Kumar
      Pages: 165 - 166
      Abstract: It is my proud privilege to introduce Prof. Anil Arora, the new INASL President, who is a brilliant scholar, an avid learner, and a clinician par excellence. Although Prof. Arora is well known to INASL members, as he is a reputed hepatologist of the country and an active INASL member, it is still my duty to introduce him to the fraternity.
      Citation: Journal of Clinical and Experimental Hepatology 6, 3 (2016)
      PubDate: 2016-09
      DOI: 10.1016/j.jceh.2016.09.010
      Issue No: Vol. 6, No. 3 (2016)
  • Hepatobiliary Quiz Questions—19 (2016)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Pages: 255 - 256
      Citation: Journal of Clinical and Experimental Hepatology 6, 3 (2016)
      PubDate: 2016-09
      DOI: 10.1016/j.jceh.2016.09.003
      Issue No: Vol. 6, No. 3 (2016)
  • Hepatobiliary Quiz Answers—19 (2016)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Pages: 257 - 260
      Abstract: Normal liver has an excellent regenerative capacity. However, this ability is impaired significantly in conditions of hepatic injury—both acute and chronic. Most of our knowledge about hepatic regeneration is derived from animal models of rats, mice and zebrafish.1 Regeneration occurs predominantly by replication of mature hepatocytes in the uninjured liver. In presence of liver injury where hepatocyte proliferation is affected, hepatocyte progenitor cells (HPC) too contribute to hepatocyte regeneration.
      Citation: Journal of Clinical and Experimental Hepatology 6, 3 (2016)
      PubDate: 2016-09
      DOI: 10.1016/j.jceh.2016.09.004
      Issue No: Vol. 6, No. 3 (2016)
  • Response to Letter to Editor
    • Authors: Panakj Puri; Vivek Saraswat
      First page: 262
      Abstract: We thank Dr. Hadigal for his interest in our work and for picking up a typographical error in Table 3.
      Citation: Journal of Clinical and Experimental Hepatology 6, 3 (2016)
      PubDate: 2016-09
      DOI: 10.1016/j.jceh.2016.09.008
      Issue No: Vol. 6, No. 3 (2016)
  • Corrigendum to “Indian National Association for Study of the Liver
           (INASL) guidance for antiviral therapy against HCV infection: Update
           2016” [J. Clin. Exp. Hepatol. 6 (2016) 119–145]
    • Authors: Pankaj Puri; Vivek A. Saraswat, Radha K. Dhiman, Anil C. Anand, Subrat K. Acharya, Shivaram P. Singh, Yogesh K. Chawla, Deepak N. Amarapurkar, Ajay Kumar, Anil Arora, Vinod K. Dixit, Abraham Koshy, Ajit Sood, Ajay Duseja, Dharmesh Kapoor, Kaushal Madan, Anshu Srivastava, Ashish Kumar, Manav Wadhawan, Amit Goel, Abhai Verma, Shalimar, Gaurav Pandey, Rohan Malik, Swastik Agrawal
      First page: 263
      Abstract: The authors regret for the typological error in Table 3 published in the original version of the article. The corrected version of Table 3 is given below:
      Citation: Journal of Clinical and Experimental Hepatology 6, 3 (2016)
      PubDate: 2016-09
      DOI: 10.1016/j.jceh.2016.09.009
      Issue No: Vol. 6, No. 3 (2016)
  • Synchronous Gall Bladder and Bile Duct Cancer: A Short Series of Seven
           Cases and a Brief Review of Literature
    • Authors: Harshal Rajekar
      Abstract: Simultaneous presence of cancer in the gall bladder and in the biliary tree could be due to local spread, metastases, de novo multifocal origin, or as part of a field change. In the past, such an association has been described in patients with anomalous pancreatico-biliary ductal junction.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-12-02
  • Noninvasive Assessment of Liver Fibrosis By Transient Elastography and
           FIB4/APRI for Prediction of Treatment Response in Chronic Hepatitis C—An
           Experience from a Tertiary Care Hospital
    • Authors: Sunil Taneja; Sunil Tohra, Ajay Duseja, Radha Krishan Dhiman, Yogesh Kumar Chawla
      Abstract: Liver fibrosis and its sequel cirrhosis represent a major health care burden, and assessment of fibrosis by biopsy is gradually being replaced by noninvasive methods. In clinical practice, the determination of fibrosis stage is important, since patients with advanced fibrosis have faster progression to cirrhosis and antiviral therapy is indicated in these patients.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-19
      DOI: 10.1016/j.jceh.2016.08.001
  • Epigastric Pain in a Patient with Cirrhosis
    • Authors: Ying C. Lee; Yi C. Yeh, Yi Y. Chiou, Chieu A. Liu, Nai C. Chiu
      Abstract: An 83-year-old man with past history of hepatitis C presented with acute onset epigastric pain for 3 days. He was diagnosed with liver cirrhosis mainly by images study, and had not received treatment for hepatitis. Laboratory analysis revealed mild hypoalbuminemia (3.5g/dL) with no other abnormalities. Dynamic computed tomography was performed, showing a heterogeneous soft tissue mass in left hepatic lobe, arterial enhancement (Figure 1, arrow) and venous phase washout (Figure 2, arrow), with linear patchy calcification at the sigmoid colonic wall (Figure 3, arrow).
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-17
      DOI: 10.1016/j.jceh.2016.09.017
  • Balloon-Occluded Retrograde Transvenous Obliteration (BRTO): A Novel
           Method of Control of Bleeding from Post-Glue Ulcer over Gastric Varices.
           Report of Two Cases and Review of Literature
    • Authors: Ritesh Prajapati; Piyush Ranjan, Arun Gupta, Ajit K. Yadav
      Abstract: Bleeding gastric varices (GV) are managed by cyanoacrylate glue injection with transjugular intrahepatic portosystemic shunt (TIPSS) as modality for treatment failure. Ulcer can form at the site of glue injection over GV and it can cause bleeding. Treatment approach for such bleed is not well described. Balloon-occluded retrograde transvenous obliteration (BRTO), TIPSS, and devascularization remain the treatment options in this scenario. BRTO is an endovascular procedure where a balloon catheter is inserted into a draining vein of GV, and the sclerosant can be injected into the varices through the catheter during balloon occlusion.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-17
      DOI: 10.1016/j.jceh.2016.08.005
  • Impact of Hepatic and Extrahepatic Insults on the Outcome of
           Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Sahaj Rathi, Swastik Agrawal, Ajay Duseja, Sunil Taneja, Yogesh Chawla
      Abstract: To study the differences in outcome and predictors of mortality in acute-on-chronic liver failure (ACLF) precipitated by hepatic or extrahepatic insults.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-16
  • Portal Inflow in Extensive Portomesenteric Thrombosis: Using the
           Pericholedochal Varix in Living Donor Liver Transplantation
    • Authors: Kishore Gurumoorthy Subramanya Bharathy; Shridhar Vasantrao Sasturkar, Piyush Kumar Sinha, Senthil Kumar, Viniyendra Pamecha
      Abstract: Extensive portomesenteric thrombosis presents a technical challenge in liver transplantation. Establishing portal inflow in living donor liver transplantation (LDLT) is indispensable to ensure regeneration of the graft. The use of a pericholedochal varix for inflow has been described only in a few case reports. Described herein is one such instance in the setting of LDLT, highlighting the nuances of this procedure in the light of available literature.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-11
  • Early Acute Severe HCV Recurrence After Transplantation: From Universal
           Mortality to Cure
    • Authors: Manav Wadhawan; Vivek Vij, Kausar Makki, Nalini Bansal, Ajay Kumar
      Abstract: Acute severe recurrence of hepatitis C virus (HCV) after solid organ transplant is associated with high mortality. Pegylated interferon and ribavirin are suboptimal in treatment of this severe form of recurrence. We report 4 cases of acute severe HCV recurrence (within 6 months after transplant), including 3 cases with fibrosing cholestatic hepatitis treated with sofosbuvir and ribavirin. All four patients achieved a rapid suppression of HCV RNA with a normalization of liver function tests within 4 weeks of starting therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-11
  • Handgrip Strength as an Important Bed Side Tool to Assess Malnutrition in
           Patient with Liver Disease
    • Authors: Praveen Sharma; Abdul Rauf, Abdul Matin, Rachit Agarwal, Pankaj Tyagi, Anil Arora
      Abstract: Malnutrition is frequently present in patients with cirrhosis. Anthropometric measures such as body mass index (BMI), mid arm muscle circumference (MAMC), triceps skin fold thickness (TST) and subjective global assessment (SGA) have some limitations in assessment of malnutrition. This study aims to determine the prevalence of malnutrition in non-hospitalized cirrhotic and chronic hepatitis patients and to assess handgrip (HG) strength as a tool for identifying malnutrition.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-10
  • Primary Biliary Cholangitis: Disease Pathogenesis and Implications for
           Established and Novel Therapeutics
    • Authors: Amitkumar Patel; Anil Seetharam
      Abstract: Primary Biliary Cholangitis is a progressive, autoimmune cholestatic liver disorder. Cholestasis with disease progression may lead to dyslipidemia, osteodystrophy and fat-soluble vitamin deficiency. Portal hypertension may develop prior to advanced stages of fibrosis. Untreated disease may lead to cirrhosis, hepatocellular cancer and need for orthotopic liver transplantation. Classically, diagnosis is made with elevation of alkaline phosphatase, demonstration of circulating antimitochondrial antibody, and if performed: asymmetric destruction/nonsupperative cholangitis of intralobular bile ducts on biopsy.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-03
  • Living Donor Liver Transplantation for Acute Liver Failure With Fixed
           Pupils: Are We Fixed'
    • Authors: Shweta A. Singh; Anshuman Singh, Viniyendra Pamecha, Chandra Kant Pandey, Shiv Kumar Sarin
      Abstract: Living donor liver transplantation (LDLT) is fraught with the social and ethical dilemma of excising a part of the liver from a healthy first-degree relative. When LDLT is to be done for an acute liver failure (ALF), identification of a suitable donor is a race against time. Herein, we describe a unique challenge faced by the transplant team of whether to proceed with donor hepatectomy from a son, when the recipient (HBV-related ALF) developed non-reactive fully dilated pupils on the table, prior to beginning the surgery.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-02
      DOI: 10.1016/j.jceh.2016.09.014
  • Hepatitis E Virus Induced Acute Liver Failure with Scrub Typhus
           Coinfection in a Pregnant Woman
    • Authors: Nipun Verma; Megha Sharma, Manisha Biswal, Sunil Taneja, Nitya Batra, Abhay Kumar, Radha K. Dhiman
      Abstract: Coinfections contribute significantly to diagnostic challenges of acute febrile illnesses, especially in endemic areas. The confusion caused by overlapping clinical features impedes timely management. Herein, we report an unusual, previously unreported case of a pregnant woman suffering from a coinfection of scrub typhus and hepatitis E virus. A 25-year-old, 31-week pregnant woman presented with jaundice for 5 days and altered sensorium for 2 days. She had features of both viral acute liver failure (ALF) and tropical infections mimicking ALF, including hyperbilirubinemia, coagulopathy, anemia, thrombocytopenia, intravascular hemolysis, and hepatosplenomegaly.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-11-01
      DOI: 10.1016/j.jceh.2016.09.015
  • The Preliminary Study on Procurement Biliary Convergence from Donors with
           Complicated Bile Duct Variant in Emergency Right Lobe Living Donor Liver
    • Authors: Sheng Ye; Jia-Hong Dong, Wei-Dong Duan, Wen-Bing Ji, Yu-Rong Liang
      Abstract: The incidence of biliary complications after living donor adult liver transplantation (LDALT) is still high due to the bile duct variation and necessity reconstruction of multiple small bile ducts. The current surgical management of the biliary variants is unsatisfactory. We evaluated the role of a new surgical approach in a complicated hilar bile duct variant (Nakamura type IV and Nakamura type II) under emergent right lobe LDALT for high model for end-stage liver disease score patients.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-10-20
      DOI: 10.1016/j.jceh.2016.09.016
  • Hepatocellular Carcinoma: An Unusual Complication of Longstanding Wilson
    • Authors: Deepak Gunjan; Shalimar, Neeti Nadda, Saurabh Kedia, Baibaswata Nayak, Shashi B. Paul, Shivanand Ramachandra Gamanagatti, Subrat K. Acharya
      Abstract: Wilson disease is caused by the accumulation of copper in the liver, brain or other organs, due to the mutation in ATP7B gene, which encodes protein that helps in excretion of copper in the bile canaliculus. Clinical presentation varies from asymptomatic elevation of transaminases to cirrhosis with decompensation. Hepatocellular carcinoma is a known complication of cirrhosis, but a rare occurrence in Wilson disease. We present a case of neurological Wilson disease, who later developed decompensated cirrhosis and hepatocellular carcinoma.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-10-05
      DOI: 10.1016/j.jceh.2016.09.012
  • What is the Risk of Graft Reinfection in Case of Liver Transplantation for
           Patients With Acute HEV or HAV Infection'
    • Authors: Anil C. Anand; Neerav Goyal, Hitendra K. Garg, Shaleen K. Agarwal, Sudeep Khanna, Subhash Gupta
      Abstract: We are sharing the concerns expressed by some colleagues about the risk of graft reinfection in case of liver transplantation (LT) for patients with acute hepatitis E (HEV) or A (HAV) virus infection. It is well known that graft reinfection is nearly universal if LT is done for active hepatitis C virus (HCV) disease.1 Before the use of hepatitis B immunoglobulin (HBIG) and/or antiviral agents for prophylaxis, hepatitis B virus (HBV) re-infection occurred in more than 80% of patients resulting in dismal graft and patient survival.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-29
      DOI: 10.1016/j.jceh.2016.09.013
  • Acute Onset Significant Muscle Weakness in a Patient Awaiting Liver
           Transplantation: Look for Statins
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Neeraj Saraf, Arvinder S. Soin
      Abstract: Statins are commonly used drugs in patients with liver and cardiac disease. Statin-induced severe myopathy is a very uncommon presentation and rhabdomyolysis may occur in extreme cases which leads to renal failure. Patients with comorbidities like diabetes, hypothyroidism, and liver disease have higher chances of development of statin-induced myopathy. We describe a case of Child's C cirrhosis wherein the patient had acute onset significant muscle weakness and improved on statin discontinuation.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-28
      DOI: 10.1016/j.jceh.2016.09.007
  • Malignant Hepatic Epithelioid Hemangioendothelioma with Villaret Syndrome
    • Authors: Hanchanale Pavan; Joy Varghese, Kavya Harika, Mukul Vij, Venkataraman Jayanthi, Mohamed Rela
      Abstract: Malignant hepatic epithelioid hemangioendothelioma is a rare, vascular tumor of the liver with peak incidence in the middle age with a female preponderance and of unknown etiology. Majority of the tumors are asymptomatic. The gold standard for diagnosis of the tumor is liver histology showing presence of epithelioid tumor cells on a background of a hyaline stroma. Immunohistochemical positivity for CD31, CD34, Factor VIII, and Podoplanin (D2-40) is confirmatory. The treatment of choice is liver transplantation.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-28
      DOI: 10.1016/j.jceh.2016.09.006
  • Unusual Presentation of Tubercular Liver Abscess in an Immune-Competent
    • Authors: Pramod Kumar; Sunil Taneja, Kirti Gupta, Ajay Duseja, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Isolated hepatobiliary tuberculosis (TB) has been uncommonly described with or without biliary involvement and accounts for less than 1% of all tubercular infections. Isolated hepatic TB is even rare and poses a great diagnostic challenge. We report a case of isolated tubercular liver abscess with extension into the chest wall in an immune-competent adult, which was diagnosed and managed successfully with antitubercular treatment.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-27
      DOI: 10.1016/j.jceh.2016.09.011
  • High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a
           High-Fat Fish-Oil Diet in C57BL/6 Mice
    • Authors: Joshua S. Wooten; Tayler N. Nick, Andrew Seija, Kaylee E. Poole, Kelsey B. Stout
      Abstract: Overnutrition of saturated fats and fructose is one of the major factors for the development of nonalcoholic fatty liver disease. Because omega-3 polyunsaturated fatty acids (n-3fa) have established lipid lowering properties, we tested the hypothesis that n-3fa prevents high-fat and fructose-induced fatty liver disease in mice.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-16
      DOI: 10.1016/j.jceh.2016.09.001
  • Giant Intrahepatic Portal Vein Aneurysm: Leave it or Treat it'
    • Authors: Amit Shrivastava; Jagdeesh S. Rampal, D. Nageshwar Reddy
      Abstract: Portal vein aneurysm (PVA) is a rare vascular dilatation of the portal vein. It is a rare vascular anomaly representing less than 3% of all visceral aneurysms and is not well understood. Usually, PVA are incidental findings, are asymptomatic, and clinical symptoms are proportionally related to size. Patients present with nonspecific epigastric pain or gastrointestinal bleeding with underlying portal hypertension. PVA may be associated with various complications such as biliary tract compression, portal vein thrombosis/rupture, duodenal compression, gastrointestinal bleeding, and inferior vena cava obstruction.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-13
      DOI: 10.1016/j.jceh.2016.08.013
  • Role of Diffusion Weighted Imaging (DWI) for Hepatocellular Carcinoma
           (HCC) Detection and its Grading on 3T MRI: A Prospective Study
    • Authors: Shiva Shankar; Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Paramjeet Singh, Radha K. Dhiman, Niranjan Khandelwal, Yogesh Chawla
      Abstract: Limited studies have evaluated the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) for histologically grading the hepatocellular carcinoma (HCC).
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-13
      DOI: 10.1016/j.jceh.2016.08.012
  • Cirrhotic Patients Have Worse Bowel Preparation at Screening Colonoscopy
           than Chronic Liver Disease Patients without Cirrhosis
    • Authors: Anika K. Anam; Kunal Karia, Arun B. Jesudian, Brian P. Bosworth
      Abstract: Cirrhosis has been shown in small studies to be a predictor of suboptimal bowel preparation at screening colonoscopy. It has yet to be established whether patients with chronic liver disease in the absence of cirrhosis experience equally poor colon cleansing. Intestinal dysmotility related to cirrhosis might impair bowel preparation in this population more than those with chronic liver disease without cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-09
      DOI: 10.1016/j.jceh.2016.08.009
  • Histological Evaluation of Non-alcoholic Fatty Liver Disease and Its
           Correlation with Different Noninvasive Scoring Systems with Special
           Reference to Fibrosis: A Single Center Experience
    • Authors: Mitali M. Rath; Manas K. Panigrahi, Kaumudee Pattnaik, Pallavi Bhuyan, Sanjib K. Kar, Bijay Misra, Debasis Misra, Chudamani Meher, Omprakash Agrawal, Jayshree Rath, Shivaram P. Singh
      Abstract: Although liver biopsy remains the gold standard for the diagnosis of non-alcoholic fatty liver disease [NAFLD], many non-invasive markers of liver fibrosis have recently been proposed and assessed as surrogates of liver biopsy.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-06
      DOI: 10.1016/j.jceh.2016.08.006
  • Rapid Onset of Fatal Lactic Acidosis Complicating Tenofovir Therapy in a
           Diabetic Patient with Cirrhosis: A Cautionary Tale
    • Authors: Ramesh Kumar; Shivani Agrawal
      Abstract: A nucleotide analogue (NA) has potential to cause mitochondrial (mt) toxicity which may lead to the development of lactic acidosis (LA).1 Tenofovir, a nucleotide analogue, induced LA is extremely rare because of its low affinity for mt DNA polymerase.2 We report a 45-year-old gentleman, with a background history of diabetes mellitus (DM) and hepatitis B virus related liver cirrhosis, who developed fatal LA after initiation of tenofovir. The patient had advanced cirrhosis with Model for End-stage Liver Disease score of 24, and he had not been on any anti-diabetic medication for 3 months.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-06
      DOI: 10.1016/j.jceh.2016.08.010
  • Multifocal Intrahepatic Artery Aneurysm with FDG-avid Thrombosis
           Simulating Metastasis: Report of a Rare Case
    • Authors: Xiaofei Zhang; Ashley E. Stueck, Sander Florman, Swan N. Thung, Sara Lewis
      Abstract: Hepatic artery aneurysm (HAA), although rare, represents a serious diagnostic and therapeutic challenge due to high rupture rate and associated mortality. Early detection and accurate diagnosis are essential for successful management. Here, we present an extremely rare case of multi-focal intrahepatic HAA with confined intrahepatic rupture and hypermetabolic activity at PET imaging, simulating metastasis of melanoma. A retrospective review found only two other HAA at our institution between 2000 and 2015, both of which involved the extrahepatic artery.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-08-27
      DOI: 10.1016/j.jceh.2016.08.002
  • Pharmacologic Treatment of Alcoholic Hepatitis: Examining Outcomes Based
           on Disease Severity Stratification
    • Authors: Ryan E. Owens; Heather S. Snyder, Jennifer D. Twilla, Sanjaya K. Satapathy
      Abstract: Maddrey discriminant function (MDF) score is a measure of disease prognosis in alcoholic hepatitis (AH) used to identify patients at highest risk of mortality and determine the need for initiation of pharmacologic treatment. The purpose of this study was to evaluate the effects of pharmacologic therapy for hospitalized AH patients as stratified by MDF score.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-08-01
      DOI: 10.1016/j.jceh.2016.07.003
  • Enucleation Sign: A Computed Tomographic Appearance of Ruptured
           Hepatocellular Carcinoma
    • Authors: Manphool Singhal; Upasna Sinha, Naveen Kalra, Ajay Duseja, Niranjan Khandelwal
      Abstract: Rupture of hepatocellular carcinoma (HCC) is a catastrophic complication, which carries high mortality. We report a case of spontaneous rupture of HCC, diagnosis of which was considered on clinical presentation and confirmed on computed tomographic (CT) scan. On CT scan, characteristic ‘enucleation sign’ was observed on arterial phase imaging, where a hypervascular peripheral mass showing central necrosis was seen protruding from liver surface with discontinuity of hepatic parenchyma associated with high attenuation ascites.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-06-06
      DOI: 10.1016/j.jceh.2016.05.004
  • Hepatocellular Carcinoma Presenting as Dyspnea at Rest due to Innumerable
           Lung Metastasis
    • Authors: Naveen Kumar; Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal
      Abstract: Hepatocellular carcinoma (HCC) the most common primary tumor of the liver usually develops in the setting of chronic liver disease. The presentation is usually due to worsening of chronic liver disease or being detected incidentally on imaging. Rarely metastasis to distant organ becomes the presentation. The authors describe a case of a 70-year-old woman who presented with dyspnea of 2 weeks duration. She was diagnosed as having HCC and extensive multiple pulmonary metastases. She was symptomatic only for the pulmonary metastasis with only 2 lesions in the liver.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-31
      DOI: 10.1016/j.jceh.2016.05.005
  • Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate
           LX-2 Cells
    • Authors: Devaraj Ezhilarasan; Jonathan Evraerts, Sid Brice, Pedro Buc-Calderon, Sivanesan Karthikeyan, Etienne Sokal, Mustapha Najimi
      First page: 167
      Abstract: Proliferation of hepatic stellate cells (HSCs) play pivotal role in the progression of hepatic fibrosis consequent to chronic liver injury. Silibinin (SBN), a flavonoid compound, has shown to possess cell cycle arresting potential against many actively proliferating cancers cell lines. The objective of this study was to evaluate the anti-proliferative and cell cycle arresting properties of SBN in rapidly proliferating human hepatic stellate LX-2 cell line.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-29
      DOI: 10.1016/j.jceh.2016.01.002
  • Hemodynamic Response to Carvedilol is Maintained for Long Periods and
           Leads to Better Clinical Outcome in Cirrhosis: A Prospective Study
    • Authors: Vijendra Kirnake; Anil Arora, Varun Gupta, Praveen Sharma, Vikas Singla, Naresh Bansal, Mohan Goyal, Romesh Chawlani, Ashish Kumar
      First page: 175
      Abstract: Non-selective beta-blockers (NSBBs), e.g. propranolol, are recommended for prophylaxis of variceal bleeding in cirrhosis. Carvedilol, a newer NSBB with additional anti-α1-adrenergic activity, is superior to propranolol in reducing portal pressure. Repeated HVPG measurements are required to identify responders to NSBB. We aimed to determine whether a single-time HVPG measurement, using acute-hemodynamic-response-testing, is sufficient to predict long-term response to carvedilol, and whether these responders have better clinical outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-06
      DOI: 10.1016/j.jceh.2016.01.004
  • Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using
           Proton Nuclear Magnetic Resonance Spectroscopy
    • Authors: Mohamed I.F. Shariff; Jin U. Kim, Nimzing G. Ladep, Mary M.E. Crossey, Larry K. Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I. Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D. Taylor-Robinson
      First page: 186
      Abstract: Discriminatory metabolic profiles have been described in urinary 1H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-04-27
      DOI: 10.1016/j.jceh.2016.03.003
  • Non-invasive Diagnosis of Oesophageal Varices Using Systemic Haemodynamic
           Measurements by Finometry: Comparison with Other Non-invasive Predictive
    • Authors: Kara Rye; Gerri Mortimore, Andrew Austin, Jan Freeman
      First page: 195
      Abstract: Cirrhosis and portal hypertension are characterised by a hyperdynamic circulation, which is independently associated with variceal size. Non-invasive techniques for measurement of systemic haemodynamics are now available.The aim of the study was to prospectively assess the accuracy of systemic haemodynamics measured non-invasively for the detection of oesophageal varices in cirrhotic patients as compared to other currently available non-invasive methods.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-20
      DOI: 10.1016/j.jceh.2016.05.001
  • Progressive Familial Intrahepatic Cholestasis (PFIC) in Indian Children:
           Clinical Spectrum and Outcome
    • Authors: Sajan Agarwal; Bikrant Bihari Lal, Dinesh Rawat, Archana Rastogi, Kishore G.S. Bharathy, Seema Alam
      First page: 203
      Abstract: To study the clinical and laboratory profile of children with progressive familial intrahepatic cholestasis (PFIC) and evaluate their outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-06-04
      DOI: 10.1016/j.jceh.2016.05.003
  • Clinical Significance of Quantitative HBsAg Titres and its Correlation
    • Authors: Vijay K. Karra; Soumya J. Chowdhury, Rajesh Ruttala, Sunil K. Polipalli, Premashis Kar
      First page: 209
      Abstract: Quantification of serum hepatitis B antigen (HBsAg) is an important test that marks active infection with hepatitis B and helps in the prediction of the clinical outcome and management of hepatitis B virus (HBV) infection. Correlation with HBV DNA quantitative levels may help in developing strategies for antiviral treatment. This study is aimed to evaluate HBsAg titres in various phase of HBV infection in HBsAg positive patients, and its correlation with HBV DNA viral load levels.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-27
      DOI: 10.1016/j.jceh.2016.07.002
  • Polymorphisms in UGT1A1 Gene Predispose South Indians to Pigmentous
    • Authors: Vishnubhotla Venkata Ravikanth; Guduru Venkat Rao, Bale Govardhan, Mitnala Sasikala, Chivukula Subramanyam, H.V. Vivekananda Murthy, Siddapuram Siva Prasad, G. Deepika, Rebala Pradeep, Duvvuru Nageshwar Reddy
      First page: 216
      Abstract: Pigmentous gallstones occur in South Indians despite significant higher levels of circulating cholesterol. This study was conducted to identify the biochemical and/or genetic causes for the formation of pigmentous gallstones in this ethnic group.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-19
      DOI: 10.1016/j.jceh.2016.08.004
  • Tackling the Hepatitis C Disease Burden in Punjab, India
    • Authors: Radha K. Dhiman; Sandeep Satsangi, Gagandeep S. Grover, Pankaj Puri
      First page: 224
      Abstract: Hepatitis C virus (HCV) is a globally prevalent pathogen and is a major cause of healthcare burden in India. HCV poses a significant problem in the state of Punjab, India owing to the higher prevalence of risk factors like unsafe medical practices (including unsafe injections and dental procedures) and intravenous drug use. The reported prevalence of HCV in this part of the country was 5.2% in 2012, while a recent study has shown the prevalence to be 3.2% in 2016. Similar to the other geographic belts in India, genotype 3 predominates in the state of Punjab.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-15
      DOI: 10.1016/j.jceh.2016.09.005
  • Acute on Chronic Liver Failure—What is in a
    • Authors: Anil C. Anand; Radha K. Dhiman
      First page: 233
      Abstract: Acute on chronic liver failure (ACLF) is a recently recognized syndrome and its definition has been evolving over last two decades. Currently, there is no universal consensus about the definition as kind of cases being seen in the Western world appear to be somewhat different from those that are seen in Asia Pacific region. But every one agrees that definition of ACLF should include following components. (a) The status of pre-existing liver disease, (b) defining the acute insult that leads to rapid deterioration of liver status, (c) time frame during which the acute insult can lead to rapid deterioration, (d) the quantification and definition of liver failure status after deterioration, which will determine the severity of ACLF, and (e) prediction of prognosis after analyzing first four components in the short and long terms.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-20
      DOI: 10.1016/j.jceh.2016.08.011
  • Delayed Severe Hemobilia Due to Bilio-venous Fistula After Percutaneous
           Transhepatic Biliary Drainage: Treatment With Covered Stent Placement
    • Authors: Kumble S. Madhusudhan; Nihar R. Dash, Adil Afsan, Shivanand Gamanagatti, Deep N. Srivastava, Arun K. Gupta
      First page: 241
      Abstract: Biliovenous fistula occurs due to development of a communication between hepatic duct and portal vein branches and is a rare complication of percutaneous transhepatic biliary drainage (PTBD). Most of them are self-limiting and only occasionally they need interventional management. Placement of biliary stent graft is a viable option. We present here a case of a 56-year-old male with carcinoma of gall bladder presenting with hemodynamic shock due to severe hemobilia after PTBD and treated successfully by biliary covered stent placement.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-04
      DOI: 10.1016/j.jceh.2016.02.002
  • Giant-cell Hepatitis—Rare Entity in Adults
    • Authors: Shiran Shetty; Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Vadakkepat Nirmala
      First page: 244
      Abstract: Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-16
      DOI: 10.1016/j.jceh.2016.02.007
  • Iatrogenic Cushing Syndrome from Interaction Between Ritonavir and Oral
           Budesonide During Direct Acting Antiviral Hepatitis C Therapy
    • Authors: Sern Wei Yeoh
      First page: 246
      Abstract: Direct acting antiviral (DAA) regimens containing ritonavir have been developed to treat hepatitis C, with fewer side effects than that by interferon-based regimens. However prescribers must be aware of drug–drug interactions. There are multiple reports of iatrogenic Cushing syndrome (CS) caused by ritonavir, when used to treat human immunodeficiency virus, increasing the bioavailability of exogenous steroids by inhibiting cytochrome p450 enzymes in the liver and gut wall and thus reducing steroid metabolism.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-31
      DOI: 10.1016/j.jceh.2016.05.006
  • Honeycomb Cyst of the Liver
    • Authors: Sunil Taneja; Pramod Kumar, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Yogesh Chawla
      First page: 250
      Abstract: A 34-year-old female presented with pain in the abdomen for 5 months. The general physical and systemic examination was normal. Ultrasound of abdomen showed two well-defined exophytic multiloculated cystic lesion of size 8.4cm×7cm and 5cm×3.2cm in segment 2/4 and 8 of the liver. Radial endoscopic ultrasound was done to confirm the diagnosis of hydatid cyst, which showed two anechoic multiseptated honeycomb-shaped cysts in liver with daughter cysts and hydatid sand (Figure 1). Later the serology for IgG antibody for hydatidosis came positive in 1:1600 titres.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-19
      DOI: 10.1016/j.jceh.2016.03.001
  • The Long Road from Obesity to Atherosclerosis via the Liver
    • Authors: Swastik Agrawal
      First page: 252
      Abstract: J Hepatol. 2016;65(July (1)):95–102.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-15
      DOI: 10.1016/j.jceh.2016.08.014
  • Comments: Indian National Association for Study of the Liver (INASL)
           Guidance for Antiviral Therapy against HCV Infection: Update 2016
    • Authors: Sanjay Hadigal
      First page: 261
      Abstract: I read with interest the above mentioned article.1 With the entry of the Direct Acting Antivirals, having an Indian guidelines for the country's clinicians is of outmost importance.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-09
      DOI: 10.1016/j.jceh.2016.08.003
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