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Journal Cover   Journal of Clinical and Experimental Hepatology
  [SJR: 0.142]   [H-I: 3]   [1 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [2801 journals]
  • Intestinal FXR: A New Therapeutic Target for Nonalcoholic Fatty Liver
    • Authors: Sawan Bopanna; Shalimar
      Pages: 264 - 266
      Abstract: Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
      Citation: Journal of Clinical and Experimental Hepatology 5, 3 (2015)
      PubDate: 2015-09
      DOI: 10.1016/j.jceh.2015.08.006
      Issue No: Vol. 5, No. 3 (2015)
  • Hepatobiliary Quiz—15 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Pages: 267 - 268
      Citation: Journal of Clinical and Experimental Hepatology 5, 3 (2015)
      PubDate: 2015-09
      DOI: 10.1016/j.jceh.2015.08.007
      Issue No: Vol. 5, No. 3 (2015)
  • Hepatobiliary Quiz (Answers)—15 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Pages: 269 - 271
      Abstract: The authors have none to declare.
      Citation: Journal of Clinical and Experimental Hepatology 5, 3 (2015)
      PubDate: 2015-09
      DOI: 10.1016/j.jceh.2015.08.008
      Issue No: Vol. 5, No. 3 (2015)
  • Variceal Banding: A Lesser-Known Complication
    • Authors: Ashish Kumar Jha; Vishwa Mohan Dayal, Baraq Ahmed, Uday Kumar, Sharad Kumar
      Abstract: Band ligation is the cornerstone of the treatment of esophageal varices. Band ligation is one of the most commonly performed endoscopic procedures. Although variceal banding is mostly a safe procedure, it may be complicated by serious adverse event.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
  • Donor Factors Including Donor Risk Index Predict Fibrosis Progression,
           Allograft Loss, and Patient Survival following Liver Transplantation for
           Hepatitis C Virus
    • Authors: Arun Jesudian; Sameer Desale, Jonathan Julia, Elizabeth Landry, Christopher Maxwell, Bhaskar Kallakury, Jacqueline Laurin, Kirti Shetty
      Abstract: The utilization of liver transplantation (LT) is limited by the availability of suitable organs. This study aimed to assess the impact of the donor risk index (DRI) and other donor characteristics on fibrosis progression, graft, and patient survival in hepatitis C virus (HCV)-infected LT recipients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
  • “Hockey Stick” may Strike Back: Hepatocellular Carcinoma on
           Noncirrhotic Liver as a Late Toxicity of Lombo-Aortic Radiotherapy for
           Seminoma. A Review Triggered by an Unusual Case
    • Authors: Clement Korenbaum; Philippe Barthelemy, Alina Onea, Pierre Salze, Jean-Emmanuel Kurtz
      Abstract: Most patients with testicular seminoma have been treated with a curative intent for decades. Second cancers after radiotherapy for testicular seminoma before 1990 are a growing issue, and are related to previous generation of dose planning and delineating strategies. Among those cancers, hepatocellular carcinoma is an extremely rare occurrence, especially when affecting patients with healthy, noncirrhotic liver. Here, we describe such a case in a patient of our institution, and subsequently review the relevant literature and large epidemiologic studies.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
  • Liver Transplantation After Bone Marrow Transplantation for End Stage
           Liver Disease with Severe Hepatopulmonary Syndrome in Dyskeratosis
           Congenita: A Literature First
    • Authors: Shyam Sunder Mahansaria; Senthil Kumar, Kishore G.S. Bharathy, Sachin Kumar, Viniyendra Pamecha
      Abstract: Dyskeratosis congenita is a multisystem genetic disorder. Although hepatic involvement is reported in about 7% of patients with dyskeratosis congenita, it is not well characterized and often attributed to hemochromatosis from frequent blood transfusions. A few case reports describe cirrhosis and hepatic cell necrosis in affected individuals in autosomal dominant pedigrees. Bone marrow failure and malignancies are the principal causes of death in dyskeratosis congenita. We describe the first case of living donor liver transplantation, in dyskeratosis congenita for decompensated cirrhosis with portal hypertension.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
  • Multiplex Reverse Transcriptase-PCR for Simultaneous Detection of
           Hepatitis B, C, and E Virus
    • Authors: Gunjan Garg; Deepak Kumar, Mohammad Asim, Syed Akhtar Husain, Bhudev C. Das, Premashis Kar
      Abstract: The hepatitis B virus (HBV), HCV, and HEV may occur as singly or concurrently in patients of different kind of liver disease. The rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. Therefore, a study has been planned to develop a multiplex Reverse Transcriptase-PCR assay which can be used for the screening of maximum number of pathogens at a time.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-30
  • Indications of Liver Biopsy in the Era of Noninvasive Assessment of Liver
    • Authors: Deepak Amarapurkar; Anjali Amarapurkar
      Abstract: Liver biopsy (LB) has been used as diagnostic modality in liver diseases (LD). Over last two decades, there has been remarkable improvement in understanding of natural history, molecular diagnostics of viral hepatitis, genetic of LD, and also limitations of LB. There is current trend in avoiding LB in the management of various LDs.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-28
      DOI: 10.1016/j.jceh.2015.08.005
  • Role of Transient Elastography (Fibroscan) in Differentiating Severe Acute
           Hepatitis and Acute on Chronic Liver Failure
    • Authors: Praveen Sharma; Rinkesh Bansal, Abdul Matin, Pankaj Tyagi, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      Abstract: It is difficult to differentiate acute severe hepatitis (AH) with acute on chronic liver failure (ACLF). Aim was to study the role of transient elastography (Fibroscan) in identifying the patients with AH and ACLF.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-27
      DOI: 10.1016/j.jceh.2015.09.004
  • Driving Performance Among Patients with Cirrhosis Who Drove to Their
           Outpatient Hepatology Clinic Appointments
    • Authors: Paul J. Thuluvath; Anantha Nuthalapati, Jennifer Price, Anurag Maheshwari
      Abstract: Minimal hepatic encephalopathy (MHE) may adversely affect driving skills.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-15
      DOI: 10.1016/j.jceh.2015.09.003
  • Upper Gastrointestinal Bleed Following Percutaneous Liver Abscess Drainage
    • Authors: Hemanta K. Nayak; Vivek A. Saraswat, Samir Mohindra, Raghunandan Prasad, Arun Karyampudi
      Abstract: A 55-year-old male was admitted to a community hospital with right upper quadrant pain and fever for two weeks. Ultrasonography showed a large right lobe liver abscess (volume 350mm3), for which he received intravenous injection metronidazole 800mg thrice daily with injection ceftriaxone 1g twice daily for seven days without any improvement. A percutaneous drain was placed successfully in the liver abscess and drained creamy pus. One week later, the percutaneous catheter was removed after improvement of symptoms.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-14
      DOI: 10.1016/j.jceh.2015.06.009
  • Indian National Association for Study of the Liver (INASL) Guidance for
           Antiviral Therapy Against HCV Infection in 2015
    • Authors: Pankaj Puri; Anil C. Anand, Vivek A. Saraswat, Subrat K. Acharya, Radha K. Dhiman, Shiv K. Sarin, Shivaram P. Singh, Yogesh K. Chawla, Rakesh Aggarwal, Deepak Amarapurkar, Anil Arora, Vinod K. Dixit, Ajit Sood, Samir Shah, Ajay Duseja, Dharmesh Kapoor, Shalimar, Kaushal Madan, Gaurav Pande, Aabha Nagral, Premashis Kar, Abraham Koshy, Amarender S. Puri, C.E. Eapen, Sandeep Thareja
      Abstract: Overall prevalence of HCV infection in India has been estimated to be approximately 1.3% in the general population. Recent introduction of sofosbuvir in India at a relatively affordable price has led to great optimism about prospects of cure for these patients. This drug is likely to form the backbone of current and future treatment regimes for HCV infection, displacing pegylated interferon. Availability of directly acting antiviral drugs (DAAs) has necessitated revision of INASL guidelines for the treatment of HCV published in 2014, as has happened across the world.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-30
      DOI: 10.1016/j.jceh.2015.09.002
  • Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians:
           A Case–Control Study
    • Authors: Shivaram P. Singh; Ayaskanta Singh, Debasis Misra, Bijay Misra, Girish K. Pati, Manas K. Panigrahi, Sanjib K. Kar, Pallavi Bhuyan, Kaumudee Pattnaik, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Manoroma Swain, Palok Aich
      Abstract: NAFLD has today emerged as the leading cause of liver disorder. There is scanty data on risk factors associated with NAFLD emanating from India. The present study was conducted to identify the risk factors associated with NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-29
      DOI: 10.1016/j.jceh.2015.09.001
  • Safety of Ascitic Paracentesis in Patients with Budd-Chiari Syndrome on
           Oral Anticoagulation and Elevated International Normalized Ratio
    • Authors: Harshad Devarbhavi; Arvind R. Murali
      Abstract: Anticoagulation is the standard of care in patients with Budd-Chiari Syndrome (BCS). Ascites is a common symptom in patients with BCS. Often such patients require paracentesis while taking oral anticoagulation concurrently. It is unclear whether paracentesis leads to increased bleeding in such patients or whether anticoagulation has to be temporarily suspended. We describe our experience with paracentesis in patients with BCS taking oral anticoagulation.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-15
      DOI: 10.1016/j.jceh.2015.08.004
  • Randomized Controlled Trial Comparing the Efficacy of Terlipressin and
           Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin
           in Hepatorenal Syndrome
    • Authors: Siddharth Srivastava; Shalimar, Sreenivas Vishnubhatla, Shyam Prakash, Hanish Sharma, Bhaskar Thakur, Subrat K. Acharya
      Abstract: Terlipressin with albumin is recommended in hepatorenal syndrome (HRS). Terlipressin is expensive and not licensed in many countries. Alternative therapy is necessary. We compared the efficacy of terlipressin and albumin with concurrent low-dose dopamine, furosemide, and albumin in HRS.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-10
      DOI: 10.1016/j.jceh.2015.08.003
  • Acute-On-Chronic Liver Failure (ACLF) in Coastal Eastern India: “A
           Single-Center Experience”
    • Authors: Girish Kumar Pati; Ayaskanta Singh, Bijay Misra, Debasis Misra, Haribhakti Seba Das, Chittaranjan Panda, Shivaram Prasad Singh
      Abstract: Acute-On-Chronic liver failure (ACLF) is an emerging entity. The present study was undertaken to analyze the clinical profile and natural course of ACLF patients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-01
      DOI: 10.1016/j.jceh.2015.08.002
  • Magnetic Resonance Imaging: Principles and Techniques: Lessons for
    • Authors: Vijay P.B. Grover; Joshua M. Tognarelli, Mary M.E. Crossey, I. Jane Cox, Simon D. Taylor-Robinson, Mark J.W. McPhail
      Abstract: The development of magnetic resonance imaging (MRI) for use in medical investigation has provided a huge forward leap in the field of diagnosis, particularly with avoidance of exposure to potentially dangerous ionizing radiation. With decreasing costs and better availability, the use of MRI is becoming ever more pervasive throughout clinical practice. Understanding the principles underlying this imaging modality and its multiple applications can be used to appreciate the benefits and limitations of its use, further informing clinical decision-making.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-08-28
      DOI: 10.1016/j.jceh.2015.08.001
  • Management Patterns of Hepatic Encephalopathy: A Nationwide Survey in
    • Authors: Praveen Sharma; Barjesh Chander Sharma
      Abstract: Hepatic encephalopathy (HE) is a common complication of cirrhosis. There is no standard practice for its management. This survey was done to determine the diagnostic and therapeutic practices of physicians treating patients with HE in patients with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-08-19
      DOI: 10.1016/j.jceh.2015.06.008
  • Attack of the Clone: HCC Tract Seeding Following RFA
    • Authors: Deepak N. Amarapurkar; Mrudul V. Dharod, Deepak Chhabra
      Abstract: A 42-year-old obese male, accidentally detected to be hepatitis B surface antigen (HBsAg) positive, presented to us in 2006. Patient was negative for antibodies to hepatitis C virus (anti-HCV) and hepatitis B envelope antigen (HBeAg) and had hepatitis B (HBV) DNA viral load of 525,073IU/ml. He had mild thrombocytopenia, mildly elevated serum transaminases, and hypoalbuminemia. Ultrasonography revealed two hypoechoic lesions in the right lobe of liver. Serum alpha-fetoprotein (AFP) levels were 4.99IU/ml whereas upper gastrointestinal endoscopy revealed small esophageal varices.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-08-06
      DOI: 10.1016/j.jceh.2015.07.204
  • Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma:
           Potential Modulation Through Quinolone Administration
    • Authors: Mohamed I.F. Shariff; Joshua M. Tognarelli, Matthew R. Lewis, Elizabeth J. Want, Fatma El Zahra Mohamed, Nimzing G. Ladep, Mary M.E. Crossey, Shahid A. Khan, Rajiv Jalan, Elaine Holmes, Simon D. Taylor-Robinson
      Abstract: The primary aim of this study was to characterise the blood metabolic profile of hepatocellular carcinoma (HCC) in a rat model, and the secondary aim was to evaluate the effect of the quinolone, norfloxacin on metabolic profiles and exploring the role that gut sterilisation may have on HCC development.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-29
      DOI: 10.1016/j.jceh.2015.07.205
  • Animal Models Correlating Immune Cells for the Development of NAFLD/NASH
    • Authors: Srikanth Iyer; Pramod Kumar Upadhyay, Subeer S. Majumdar, Perumal Nagarajan
      Abstract: This review mainly elaborates on the animal models available for understanding the pathogenesis of the second hit of non-alcoholic fatty liver disease (NAFLD) involving immune system. This is known to be a step forward from simple steatosis caused during the first hit, which leads to the stage of inflammation followed by more serious liver conditions like non-alcoholic steatohepatitis (NASH) and cirrhosis. Immune-deficient animal models serve as an important tool for understanding the role of a specific cell type or a cytokine in the progression of NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-23
      DOI: 10.1016/j.jceh.2015.06.004
  • Addition of Somatostatin After Successful Endoscopic Variceal Ligation
           does not Prevent Early Rebleeding in Comparison to Placebo: A Double Blind
           Randomized Controlled Trial
    • Authors: Ashish Kumar; Sanjeev K. Jha, Vibhu V. Mittal, Praveen Sharma, Barjesh C. Sharma, Shiv K. Sarin
      Abstract: Efficacy of endoscopic sclerotherapy in controlling acute variceal bleeding is significantly improved when vasoactive drug is added. Endoscopic variceal ligation (EVL) is superior to sclerotherapy. Whether efficacy of EVL will also improve with addition of somatostatin is not known. We compared EVL plus somatostatin versus EVL plus placebo in control of acute variceal bleeding.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-08
      DOI: 10.1016/j.jceh.2015.06.001
  • Complications of Catheter Drainage for Amoebic Liver Abscess
    • Authors: Navneet Sharma; Harpreet Kaur, Naveen Kalra, Ashish Bhalla, Susheel Kumar, Virendra Singh
      Abstract: Per-cutaneously inserted catheter drainage is an accepted treatment modality for a large amoebic liver abscess. Complications that can arise are; secondary infection, bleeding into the abscess cavity, inadvertent catheter misplacement into the IVC and rupture of abscess with spillage into the peritoneal cavity. We report a case of a large amoebic liver abscess that presented with complications related to per-cutaneously inserted catheter drainage.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-04
      DOI: 10.1016/j.jceh.2015.06.003
  • Epidemiology of Liver Cirrhosis
    • Authors: Cristina Stasi; Caterina Silvestri, Fabio Voller, Francesco Cipriani
      Abstract: Liver cirrhosis is a major public health problem and a significant source of morbidity and mortality that is preventable and underestimated.1 It represents the main indication for liver transplantation in both United States and Europe.2
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-06-25
      DOI: 10.1016/j.jceh.2015.06.002
  • Fluorine-18 Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma:
           Correlation with Glucose Transporters and p53 Expression
    • Abstract: Hepatocellular Carcinoma (HCC) is one of most lethal cancers worldwide. The prognosis is very poor and therapeutic options are limited. The aim of this study was to determine the correlation of the [18F]FDG uptake profile of three HCC cell lines with p53 and glucose transporters (GLUTs) 1, 2, 3, 5 and 12 expression and with the glucose level present in the cell culture medium.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-06-24
      DOI: 10.1016/j.jceh.2015.05.003
  • HBsAg Level as Predictor of Liver Fibrosis in HBeAg Positive Patients With
           Chronic Hepatitis B Virus Infection
    • Authors: Sundeep K. Goyal; Ashok K. Jain, Vinod K. Dixit, Suneet K. Shukla, Mohan Kumar, Jayant Ghosh, Arttrika Ranjan, Neha Gupta, Manish Tripathi
      Abstract: Preliminary data suggests lower serum hepatitis B surface antigen level is associated with more severe liver fibrosis in HBeAg positive patients. We evaluated the association of HBsAg level with biochemical, virological, and histological features in asymptomatic patients with chronic HBV infection.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-06-05
      DOI: 10.1016/j.jceh.2015.04.008
  • Hepatitis C Virus (HCV) Infection in Patients with End Stage Renal
           Disease: A Study from a Tertiary Care Centre in India
    • Authors: Anil Arora; Naresh Bansal, Praveen Sharma, Vikas Singla, Varun Gupta, Pankaj Tyagi, Manish Malik, Ashish Kumar
      Abstract: Hepatitis C Virus (HCV) infection is common in patients with end stage renal disease (ESRD) and is an important cause of liver disease. We describe the demographic, clinical and biochemical profile of these patients from a tertiary care center of north India.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-05-15
      DOI: 10.1016/j.jceh.2015.04.004
  • Remogliflozin Etabonate Improves Fatty Liver Disease in Diet-Induced Obese
           Male Mice
    • Authors: Shigeru Nakano; Kenji Katsuno, Masayuki Isaji, Tatsuya Nagasawa, Benjamin Buehrer, Susan Walker, William O. Wilkison, Bentley Cheatham
      Abstract: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are serious conditions and are being diagnosed at an increased rate. The etiology of these hepatic disorders is not clear but involves insulin resistance and oxidative stress. Remogliflozin etabonate (Remo) is an inhibitor of the sodium glucose-dependent renal transporter 2 (SGLT2), and improves insulin sensitivity in type 2 diabetics. In the current study, we examined the effects of Remo in a diet-induced obese mouse model of NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-04-27
      DOI: 10.1016/j.jceh.2015.02.005
  • Acute Portal Vein Thrombosis, No Longer a Contraindication for
           Transjugular Intrahepatic Porto-Systemic Shunt (TIPS) Insertion
    • Authors: Suraj Mammen; Shyamkumar N. Keshava, Sajith Kattiparambil
      Abstract: Portal vein thrombosis, once considered as a contraindication to transjugular intrahepatic porto-systemic shunt (TIPS) is now considered as an indication. We report a case with clinical and technical success in a patient with Budd Chiari syndrome and acute portal venous thrombosis. Though it is a well-established option, with the best of our knowledge, we could not find a report from India.
      Citation: Journal of Clinical and Experimental Hepatology (2014)
      PubDate: 2014-09-20
      DOI: 10.1016/j.jceh.2014.08.008
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