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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.283]   [H-I: 7]   [3 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [3042 journals]
  • Association of Alterations in HBV Genome With Progression of HBV Related
           Chronic Liver Disease—A Study From Bangladesh
    • Authors: Ruksana Raihan; Mamun A. Mahtab, Sheikh M.F. Akbar
      Abstract: Background and Aim: Although the direct role of hepatitis B virus (HBV) has not been substantiated in directing different pathological stages of chronic HBV infection, there is paucity of information regarding this as analysis of HBV genome has not been accomplished from different populations and countries, especially from developing countries. Here, we have analyzed HBV genome from patients with asymptomatic HBV carrier [ASC]), chronic hepatitis B (CHB), cirrhosis of liver (LC), and hepatocellular carcinoma (HCC) of Bangladeshi origin to expand previous findings about this.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.212
      Issue No: Vol. 7 (2017)
       
  • Comparative Study of Treatment Outcome With Tenofovir and Telbivudine in
           Patients With Hepatitis B Related Acute on Chronic Liver Failure
    • Authors: Debraj Malakar; Mamun Al-Mahtab, Sheikh M. Noor-E-Alam, Abul H. Manik, Abdullah A. Masum, Ayub A. Mamun, Salimur Rahman
      Abstract: Background and Aim: General objective was to study the differences in treatment outcome with tenofovir and telbivudine in ACLF-B patients. Specific objectives were to observe survival at 90 days and calculate CTP score and MELD score in these two groups.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.211
      Issue No: Vol. 7 (2017)
       
  • Predictors of Prognosis/Outcome in Patients With HCC Undergoing TACE,
           Experience From a Tertiary Care Centre in South India
    • Authors: Gaurav Kapur; Aniruddha Pratap Singh, Shahana Fathima, Varun Tadkalkar, Rajendra Gunjal, Sandeep Narayanan, Neehar Shanavas, Chethan Govindaraju, Sandesh Kumar, Krishnadas Devdas
      Abstract: Background and Aim: TACE is an established modality of treatment for patients with intermediate-stage HCC according to the BCLC classification. However intermediate group comprises a heterogeneous population and factors predicting the outcome and prognosis in this group are still under debate. We aimed to study factors determining the outcome in patients of HCC undergoing TACE.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.210
      Issue No: Vol. 7 (2017)
       
  • Significance of Elevated Cyst Fluid Levels in Walled Off Pancreatic
           Necrosis—A Case Report
    • Authors: Rahul D. Arora
      Abstract: Background: Pancreatic cyst fluid analysis can be used to characterize mucinous cystic lesions of the pancreas into benign and malignant. Thin brown fluid, low CEA levels, absence of KRAS and GNAS mutations and high amylase levels have been reported on pancreatic pseudocyst fluid analysis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.206
      Issue No: Vol. 7 (2017)
       
  • Rospective Study of the Role of Duodenal Bulb Biopsies in the Diagnosis of
           Celiac Disease
    • Authors: Shashank Wanjari; Bhanwar S. Dhandhu, Pushpa Mehra, Gaurav K. Gupta, Sandeep Nijhawan
      Abstract: Background and Aim: Celiac disease is a systemic immune mediated disorder triggered by dietary gluten in genetically susceptible persons. D1 had been avoided as a possible biopsy site because of concerns over presence of Brunner's glands, gastric metaplasia, peptic duodenitis, and presumed reduced villous height. Prospective data from small studies has suggested that D1 may be the only site of villous atrophy in newly diagnosed celiac disease (ultra-short celiac disease). We wanted to verify this concept that whether the addition of duodenal bulb biopsy increase the diagnostic yield of celiac disease and was there any difference in histological grading between the two sites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.205
      Issue No: Vol. 7 (2017)
       
  • Clinical Profile and Outcomes of Primary Sclerosing Cholangitis in a
           Tertiary Care Centre
    • Authors: Pratik S. Tibdewal; Pratin Bhatt, Abhishek Sadalage, Abhinav Jain, Shobna Bhatia, Akash Shukla
      Abstract: Background and Aim: Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease. Current epidemiological data are limited to studies of western populations. Our aim was to define the profile of PSC in an ethnically diverse Indian population.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.204
      Issue No: Vol. 7 (2017)
       
  • Diagnosing Wilson's Disease–United We Stand Divided We Fall: A Five-year
           Pathological Perspective at a North Indian Tertiary Referral Centre
    • Authors: Kavita Gaur; Puja Sakhuja, Kaushik Majumdar, Siddharth Srivastava, Amarender Singh
      Abstract: Background and Aim: Diagnosing Wilson's disease [WD] is a challenge for the clinician and the pathologist. Clinical manifestations of WD are protean. Conflicting biochemical reports &/non-conclusive histology delay therapeutic initiation. Though genetic analysis is considered gold standard, cost issues hinder mutational analysis. Recent work on the pathological spectrum of Indian cases of WD is sparse. The present study was carried out to analyze the utility of the liver biopsy in clinching the final diagnosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.203
      Issue No: Vol. 7 (2017)
       
  • Pediatric Hepatic Wilson's Disease: Experience From a Tertiary Care Center
    • Authors: Mridul C. Das; Moinak S. Sarma, Surender K. Yachha, Anshu Srivastava, Ujjal Poddar
      Abstract: Background and Aim: As there is paucity of exclusive literature on pediatric hepatic Wilson's disease (WD), this study was aimed to evaluate clinical presentation and outcome of children with hepatic WD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.202
      Issue No: Vol. 7 (2017)
       
  • Comparison of Risk Scores in Upper Gastrointestinal Bleed in a Tertiary
           Care Centre in Western India
    • Authors: Sanjay Chandnani; Suhas Udgirkar, Nikhil Sonthalia, Sunil Pawar, Samit Jain, Ravindra Surude, Qais Contractor, Pravin Rathi
      Abstract: Background and Aim: Upper gastrointestinal bleed causes significant morbidity and mortality all over world. Aim of our study was to identify risk scores (AIM65, GBS, ROCKALL, PNED) predicting admission, need of intervention, etiology and mortality of upper gastrointestinal bleed.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.201
      Issue No: Vol. 7 (2017)
       
  • Effect of Paracentesis and Albumin on Non-azotemic Renal Dysfunction in
           Children With Cirrhosis
    • Authors: Durga Prasad; Surender K. Yachha, Moinak S. Sarma, Raghunandan Prasad, Anshu Srivastava, Ujjal Poddar
      Abstract: Background and Aim: Prevalence of renal dysfunction (RD) is unknown in cirrhotic children. Renal resistive index is a non-invasive tool to detect early RD before azotemia sets in. We aimed to detect RD in children with chronic liver disease by renal doppler ultrasonography (DU) and observe the effect of paracentesis and albumin infusion on renal resistive index
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.200
      Issue No: Vol. 7 (2017)
       
  • Gallbladder Ejection Fraction and Sphincter of Oddi Dysfunction in Acute
           Idiopathic and Acute Recurrent Pancreatitis in Children
    • Authors: Srikanth P. Kadyada; B.R. Thapa, Sadhna B. Lal, Anish Bhattacharya, Jagadesh Menon, Subhamoy Das
      Abstract: Background and Aim: Gallbladder (GB) dysfunction leading to biliary sludge formation and sphincter of Oddi dysfunction (SOD) are the important causes of idiopathic acute pancreatitis (idiopathic AP) and acute recurrent pancreatitis (ARP) in adults. However, this is not investigated in children. We prospectively evaluation for gallbladder (GB) dysfunction and sphincter of Oddi dysfunction (SOD) in children with idiopathic and recurrent AP.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.199
      Issue No: Vol. 7 (2017)
       
  • Assessment of Body Composition by Bioelectrical Impedance Analysis in
           Patients With Cirrhosis
    • Authors: Indu Grover; Namrata Singh, Deepak Gunjan, Hem Sati, Anoop Saraya
      Abstract: Background and Aim: The cirrhotic patients are usually malnourished and they also have ascites when decompensated. The body composition in patients with cirrhosisis not well characterized. The study was done to assess body composition of the patients with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.198
      Issue No: Vol. 7 (2017)
       
  • Danis Ella Stent Placement in the Management of a Lower End Esophageal
           Bleeding in a Post Liver Transplant Patient: A Case Report
    • Authors: Chetan Kalal; Akash Shukla, Mihir Vora, Hunaid Hatimi, Samir Shah, Amit Maydeo
      Abstract: Background: Danis Ella stent has been used for refractory esophageal variceal and post EVL ulcer related bleed. Here we describe its use in an unusual situation.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.197
      Issue No: Vol. 7 (2017)
       
  • Plasma von Willebrand Factor Levels in Discrete Syndromes of Liver Disease
    • Authors: Madeline Vithya; Ashish Goel, Sukesh C. Nair, Uday G. Zachariah, K.G. Sajith, C.E. Eapen, K.A. Balasubramanian, Elwyn Elias, Tulasi Geever, Ancy Abraham
      Abstract: Background and Aim: The study was conducted to assess plasma von Willebrand Factor (vWF) levels in different liver syndromes.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.196
      Issue No: Vol. 7 (2017)
       
  • Endoscopic Biliary Drainage in an Amoebic Liver Abscess (ALA) With
           Persistent Biliary Communication
    • Authors: Apurva S. Shah; Shravan Bohra
      Abstract: Background: Liver abscess with biliary communication poses management problem if percutaneous drainage is performed. We report our experience with the use of therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in the management of patient with amoebic liver abscess (ALA) with biliary communication.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.195
      Issue No: Vol. 7 (2017)
       
  • Clinical Study of Ascites With Special Reference to Serum Ascites Albumin
           Gradient
    • Authors: Kiran D. Shinde; Praveen Kumar, Praveen Mathew, Prashant Kanni, Vishakha Khalde, Suraj Ujjalapati, Mounika Killari, P. Manjunath, S. Shruthi, Nishant Dubey
      Abstract: Background and Aim: Ascites is a common clinical problem with broad aetiology. Cost effective and widely available biochemical parameters are required to differentiate Ascites which can correlate with pathogenesis and pin point towards an aetiology with high sensitivity and significant accuracy. Aim of the study was to understand clinical profile and to determine the sensitivity, specificity and diagnostic efficacy of serum Ascites albumin Gradient (SAAG) in evaluating their diagnostic role in identifying the aetiology of Ascites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.194
      Issue No: Vol. 7 (2017)
       
  • Prevalence and Spectrum of Biliary Abnormalities in Extrahepatic Portal
           Venous Obstruction—A Tertiary Centre Experience
    • Authors: Senthamizh Selvan; Pugazhendhi Thangavelu, Mohammed Ali
      Abstract: Background and Aim: Portal cavernoma cholangiopathy (PCC) refers to abnormalities in extra hepatic biliary system including cystic duct and gallbladder with or without involvement of 1st and 2nd generation biliary ducts in a patient with portal cavernoma. The symptoms of PCC usually develop late in the course of portal hypertension. Magnetic resonance cholangiography (MRC) and portovenography is the non-invasive modality of choice for characterization of PCC. Portal decompression alone can change the natural history of PCC.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.193
      Issue No: Vol. 7 (2017)
       
  • Role of Portosystemic Shunt Surgery in the Current Era of Endoscopic
           Therapy in Extrahepatic Portal Venous Obstruction
    • Authors: Moinak S. Sarma; Richa Lal, Surender K. Yachha, Anu Behari, Anshu Srivastava
      Abstract: Background and Aim: There is scant literature on long term follow-up of EHPVO children, following endoscopic eradication of esophageal varices (EEEV). This study addresses the delayed sequelae of EHPVO that have evolved over 2 decades beyond EEEV requiring portosystemic shunt surgery (PSS) and their surgical outcome.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.192
      Issue No: Vol. 7 (2017)
       
  • Dysregulation of Long Non-coding RNAS in Hepatocellular Carcinoma-Current
           Implications and Perspectives
    • Authors: Papai Roy; Gaurav Roy
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC), a fatal human malignancy, accounts for 90% of primary liver cancers worldwide. In conjunction with several cellular, molecular and genetic aberrations, dysregulation of a variety of non-coding RNAs such as long non-coding RNAs (LncRNAs) have been implicated in HCC. LncRNAs are endogenous cellular RNAs that play pivotal roles in the modulation of the tumor microenvironment in several malignant processes such as initiation, progression, and dissemination.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.191
      Issue No: Vol. 7 (2017)
       
  • Clinical Spectrum and Outcome of Gallstones in Children and Adolescents
    • Authors: Subhamoy Das; Babu R. Thapa, Sadhna B. Lal, K.P. Srikanth
      Abstract: Backgrounds and Aim: Gall stone disease is uncommon in infants and children. We analyzed patients with gallstone disease to study the pattern of presentation, etiology and outcome.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.190
      Issue No: Vol. 7 (2017)
       
  • Endovascular Intervention in Budd-Chiari Syndrome
    • Authors: Nitin Jagtap; Mithun Sharma, Jagadeesh R. Singh, P.N. Rao, Rajesh Gupta, T. Maheshkumar, Sunil Kumar, Naga Bhushan, D.N. Reddy.
      Abstract: Background and Aim: Outcomes of endovascular intervention in Budd-Chiari syndrome (BCS) have been reported with varied results. Clinical outcomes of endovascular interventions in BCS and role of various prognostic scores were critically evaluated in this study.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.189
      Issue No: Vol. 7 (2017)
       
  • Identification of Potential Genetic Modifiers in Noncirrhotic Portal
           Hypertension (NCIPH)
    • Authors: Rekha Athiyarath; Ashish Goel, Aaron Chapla, Nihal Thomas, K.A. Balasubramanian, C.E. Eapen, Elwyn Elias
      Abstract: Background: NCIPH is characterised by occlusion of small intra-hepatic portal vein radicles. Recent reports suggest a possible familial occurrence in NCIPH (mutations in KCNN3 and DGUOK genes). Furthermore, published literature points to the possibility of localised thrombotic microangiopathy contributing to the pathogenesis of NCIPH.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.188
      Issue No: Vol. 7 (2017)
       
  • CRISPR-Cas9 Technology as a Fledgling Avenue in the Therapeutics of
           Hepatocellular Carcinoma
    • Authors: Gaurav Roy; Papai Roy
      Abstract: Background and Aim: Since its inception in 2012, the prokaryotic immune-like clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein (Cas)9 (CRISPR-Cas9) system has revolutionised the realm of genome editing with visionary implementations in synthetic biology, functional genomic screening, transcriptional modulation and gene therapy. Hepatocellular carcinoma (HCC) with a globally heterogeneous genetic and epigenetic landscape, is a fatal human malignancy, and therefore forms the perfect platform for therapeutic interventions with CRISPR-Cas9.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.187
      Issue No: Vol. 7 (2017)
       
  • Prospective Evaluation of Sclerosing Cholangitis in Children With
           Autoimmune Liver Disease
    • Authors: Nagendra Kumar; Ujjal Poddar, Rajanikant Yadav, Surender K. Yachha, Anshu Srivastava
      Abstract: Background and Aim: Autoimmune liver disease encompass “overlap syndromes” of autoimmune hepatitis (AIH) with primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). In children only AIH-PSC overlap syndrome also known as ‘autoimmune sclerosing cholangitis’ (ASC) has been recognized. We aimed to study prevalence of ASC by using MRC in children diagnosed as AIH, and to compare the clinical presentation and outcome of children with AIH and ASC, and compare cholangiographic appearance in AIH and in children with cirrhosis due to non-autoimmune, non-biliary etiology.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.186
      Issue No: Vol. 7 (2017)
       
  • Liver and Peritoneal Metastasis in Multiple Myeloma
    • Authors: Ajinkya Sonambekar; Devendra Desai, Philip Abraham, Anand Joshi, Tarun Gupta, Vatsal Mehta
      Abstract: Background and Aim: Liver or peritoneal metastasis in multiple myeloma (MM) is rare. We report two such patients: one had space-occupying lesions (SOL) in the liver and the other had ascites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.185
      Issue No: Vol. 7 (2017)
       
  • Expression of Pro-inflammatory Cytokines in Human Metabolic Syndrome
    • Authors: V. Rakotoarivelo; M. Mayhue, M.F. Langlois, S. Ramanathan
      Abstract: Background and Aim: Obesity is emerging as a major healthcare burden. Excess visceral adiposity is associated with insulin resistance (IR), type 2 diabetes (T2D), atherosclerosis, hypertension and fatty liver disease. Adipose tissue is considered as an endocrine organ in addition to its primary function as a depot where energy is stored in the form of triglycerides for release during starvation, exercise or infections. However, when the adipose tissue is unable to stockage the excessive nutrient influx, insulin resistance develops in a progressive manner.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.184
      Issue No: Vol. 7 (2017)
       
  • Predictors of Advanced Fibrosis in Nonalcoholic Fatty Liver Disease,
           Chronic Heptitis B, Chronic Hepatitis C
    • Authors: Rajendra Gunjal; Aniruddha P. Singh, Gaurav Kapoor, N. Sandeep, Rathan Cyriac, S. Srijaya, Krishnadas Devadas
      Abstract: Background and Aim: Transient elastography (TE) using ultrasound offers great promise in providing accurate and reliable information among Non alcoholic fatty liver disease (NAFLD), chronic Hepatitis B (CHB), chronic Hepatitis C (CHC), patients with advanced fibrosis and cirrhosis. The study was done to find out the prevalence and factors associated with advanced fibrosis among NAFLD, CHB, CHC, patients using TE.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.183
      Issue No: Vol. 7 (2017)
       
  • To Study Role of Fibroscan as a Noninvasive Tool for Screening of Liver
           Disease in Patients on Maintenance Haemodialysis—A Preliminary Data
    • Authors: Mahesh U. Patil; Sethu Babu
      Abstract: Background and Aim: Liver disease is a serious comorbid condition adding to morbidity of CKD patients particularly in advanced stages especially in patients who are on Maintenance Haemodialysis (MHD). Diabetes, viral infections etc. are important causes of liver involvement in CKD patients. Liver Enzymes do not assess severity of liver disease in CKD. Routine imaging of liver is unable to determine fibrosis and steatosis and liver Biopsy has significant complications. In this study we evaluated Fibroscan as a non-invasive tool to assess liver fibrosisin advanced stages of CKD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.182
      Issue No: Vol. 7 (2017)
       
  • Is Fibroscan a Substitute to Ultrasound in Prdicting Liver Fibrosis'
    • Authors: Md. F. Karim; Provat K. Podder, Md. N. Islam, Faroque Ahmed, Mamun Al-mahtab, Salimur Rahman
      Abstract: Background and Aim: Conventionally ultrasound examination of hepatobiliary system is undertaken to assess non-specifically the liver echotexture. However at times we do find chronic liver disease even cirrhosis of liver having normal liver echotexture on ultrasound examination. Liver biopsy though gold standard is invasive, costly. Therefore it is always a need for more specific test. Fibroscan is newly introduced test in hepatology practice. A fibroscan value of
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.181
      Issue No: Vol. 7 (2017)
       
  • Nutritional Status of Patients Budd-Chiari Syndrome
    • Authors: Niyati Mehta; Meena Godhia, Abhinav Jain, Shobna Bhatia, Akash Shukla
      Abstract: Background and Aim: Malnutrition is prevalent in cirrhosis and associated with increased number of complications and increased short and long term mortality. The prevalence or impact of malnutrition has not been studied in patients with Budd-Chiari syndrome (BCS). We studied nutritional parameters in BCS and compared them to cirrhotics.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.180
      Issue No: Vol. 7 (2017)
       
  • Role of Magnetic Resonance Elastography in Assessment of Liver Fibrosis in
           Patients With Non-cirrhotic Portal Fibrosis
    • Authors: Akash Shukla; Sangeet Sawrav, Ashlesha Udare, Samir Shah, Abhinav Jain, Shobna Bhatia
      Abstract: Background and Aim: Non-cirrhotic portal fibrosis (NCPF) is diagnosed by liver biopsy, which is invasive, has potential complications and limited by sampling error and inter-observer variability. MR Elastography (MRE) is validated to assess liver fibrosis. We did this study to assess MRE findings in patients with NCPF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.179
      Issue No: Vol. 7 (2017)
       
  • Bleeding Complications in Patients With Budd-Chiari Syndrome on
           Anticoagulation
    • Authors: Abhinav Jain; Chirag Shah, Pratin Bhatt, Megha Meshram, Shobna Bhatia, Akash Shukla
      Abstract: Background and Aim: Anticoagulation is recommended for all patients with Budd-Chiari syndrome (BCS). Bleeding complications occur in approximately 20% patients with BCS on anticoagulants. This study aim to study the incidence and severity of bleeding episodes in these patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.178
      Issue No: Vol. 7 (2017)
       
  • Diagnostic Accuracy, Safety and Impact of Endoscopic Ultrasound Fine
           Needle Aspiration of Enlarged Left Adrenal in Patients With Decompensated
           Cirrhosis
    • Authors: Amit Agarwal; Narendra S. Choudhary, Rinkesh K. Bansal, Sanjiv Saigal, Neeraj Saraf, Haimanti Sarin, Gagandeep Kaur, Rajesh Puri
      Abstract: Background and Aim: The conventional ultrasound and CT guided FNA of left adrenal is difficult due to anatomic location and presence of collaterals. EUS guided FNA of adrenals offers several advantages like real-time vision, proximity to target and avoidance of collaterals by Doppler application. There is no data on outcomes of endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of adrenals in patients with decompensated cirrhosis other than case reports.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.177
      Issue No: Vol. 7 (2017)
       
  • Clinical Profile of Chronic Liver Disease in Children: Experience From a
           Tertiary Care Teaching Hospital in South India
    • Authors: Prasanth K. Sobhan; Bindu Sarojam, Rekha Krishnan, A. Santhosh Kumar, Krishnadas Devadas
      Abstract: Background and Aim: Chronic liver diseases constitute one third of referral to paediatric gastroenterology (PGE) OP from various centres in North India from the published data. Our centre is the only tertiary care teaching hospital under public sector in the state of Kerala with a PGE clinic. In this context, we undertook this study to determine the clinical profile of chronic liver disease in children from South India. The study was done to determine the aetiology as well as clinical profile of chronic liver disease in children from a tertiary care teaching hospital in South India.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.176
      Issue No: Vol. 7 (2017)
       
  • Disease Spectrum of Obstructive Jaundice in Patients From Western
           Rajasthan
    • Authors: Kartik Goyal; Sunil Dadhich
      Abstract: Background and Aim: Extra Hepatic Biliary Obstruction is one of the most common problems we encounter in patients presenting with Jaundice. There have been various studies with different etiological share in different parts of our country. Management depends on correctly identifying the nature of the disease. The aim of the present study is to clarify cause, site of obstruction, difference in natural history of diseases causing obstructive jaundice as seen at a tertiary referral center in patients from Western Rajasthan.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.175
      Issue No: Vol. 7 (2017)
       
  • Profile of Obstructive Jaundice in Tertiary Referral Hospital
    • Authors: V. Gopalakrishna; P. Shravankumar, M. Umadevi
      Abstract: Background and Aim: Obstructive jaundice is one of common referral to gastroenterology. In this study, we aimed at identifying clinical and etiological profile of obstructive jaundice in patients referred for ERCP.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.174
      Issue No: Vol. 7 (2017)
       
  • Gastrointestinal Bleed in Inpatient Cases of Liver Abscess
    • Authors: Sudhir Singh; Vinod K. Dixit, Sunit K. Shukla
      Abstract: Background and Aim: Our aim was to study the presentation, endoscopy findings and clinical outcome in patients admitted with liver abscess who developed gastrointestinal bleed before or during the course of hospitalisation at our centre.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.173
      Issue No: Vol. 7 (2017)
       
  • Spectrum of Pediatric Wilson Disease From a Non-transplant Tertiary Care
           Center in North India
    • Authors: Jagadeesh Menon; B.R. Thapa, K.P. Srikanth, Shruti Sharma, S. Lal
      Abstract: Background and Aim: Wilson disease is a rare disorder of copper metabolism. There is a scarcity of reported series on this disorder in the pediatric age group. The study was done to evaluate the spectrum of Wilson disease in children managed in our institute.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.172
      Issue No: Vol. 7 (2017)
       
  • Hemospray for Recurrent Oesophageal Band Ulcer Bleeding
    • Authors: Uday A. Sanglodkar; Dinesh Jothimani, Mohamed Rela
      Abstract: Background: Rebleeding after initially successful Endoscopic variceal ligation (EVL) occurs in 20–60% of patients, most commonly from band ulcers, and is associated with 20–50% mortality. Hemospray is a relatively new non-contact haemostatic modality utilized in the management of bleeding peptic ulcers.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.171
      Issue No: Vol. 7 (2017)
       
  • Weekly Regimen of Vitamin D Supplementation is More Effective Than Stoss
           Regimen for Treatment of Hypovitaminosis D in Children With Chronic Liver
           Disease
    • Authors: Bikrant B. Lal; Rajeev Khanna, Seema Alam, Dinesh Rawat
      Abstract: Background and Aim: There are no evidence-based recommendation on the ideal dose and regimen for supplementation of Vitamin D in children with CLD. The study aimed to compare the safety and efficacy of weekly and stoss regimens for treatment of hypovitaminosis in children with CLD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.170
      Issue No: Vol. 7 (2017)
       
  • Long Term Outcomes of Transjugular Intrahepatic Portosystemic Shunt in
           Indian Patients With Budd-Chiari Syndrome
    • Authors: Shalimar; Shivanand R. Gamanagatti, Arpan H. Patel, Saurabh Kedia, Baibaswata Nayak, Deepak Gunjan, Gyan Ranjan, Shashi B. Paul, Subrat K. Acharya
      Abstract: Background and Aim: Transjugular intrahepatic portosystemic shunt (TIPS) is the treatment of choice in Budd-Chiari syndrome (BCS) based on current data. Our objective was to evaluate outcomes and assess prognostic factors in BCS patients undergoing TIPS.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.169
      Issue No: Vol. 7 (2017)
       
  • Temporal Trends in the Etiology of Chronic Liver Disease in Coastal
           Eastern Odisha
    • Authors: Debakanta Mishra; Kaibalya R. Dash, Preetam Nath, Prasant K. Parida, Subhendu Panigrahi, Chittaranjan Khatua, Suryakant Parida, Sambit K. Behera, Shivaram P. Singh, Palok Aich
      Abstract: Background and Aim: The etiology of chronic liver disease (CLD) is known to change with time due to various factors including awareness, preventive interventions as well as life style changes in society. However there is scarce Indian data available about time trends in etiology of CLD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.168
      Issue No: Vol. 7 (2017)
       
  • Case of Cholestatic Jaundice
    • Authors: Mounika Kilari; V.S.M. Praveen Kumar, Praveen Mathew, Prashanth Y. Kanni, Manjunath Patil, Kiran Shinde, Suraj Uppalapati
      Abstract: Background: Abdominal tuberculosis is the most common form of extrapulmonary tuberculosis, but very rarely involves the biliary tree. Either the primary biliary tuberculosis or external compression by adjacent organs can lead to formation of strictures that may be single or multiple and are difficult to diagnose accurately. Here is a 43 years old female with a history of obstructive jaundice due to hilar stricture which turned out to be tuberculosis induced.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.167
      Issue No: Vol. 7 (2017)
       
  • Assessment of Bone Disease in Cirrhosis of Liver
    • Authors: Prateik Poddar; Harshad B. Khairnar
      Abstract: Background and Aim: We attempted to study bone density, site of measurement, cutoff for screening and vitamin D deficiency in chronic liver disease.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.166
      Issue No: Vol. 7 (2017)
       
  • Comparison of Safety Profile of ERCP in Patients With Cirrhotic and
           Non-cirrhotic Portal Hypertension
    • Authors: Paul K. Vincent; Rajesh Gopalakrishna, H.K. Nandish, Harshavardhan B. Rao, Anoop K. Koshy, Shine Sadasivan, Rama P. Venu
      Abstract: Background and Aim: Reports suggest that patients with cirrhosis may be prone for adverse events following ERCP due to underlying coagulopathy, hepatic dysfunction, portal hypertension and other systemic derangements.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.165
      Issue No: Vol. 7 (2017)
       
  • Transient Elastography has Limited Efficacy for Fibrosis Assessment in end
           Stage Renal Disease Patients on Maintenance Hemodialysis With Suspected
           Liver Disease
    • Authors: Sunil Taneja; Amritangsu Borkakoty, Sahaj Rathi, Ajay Duseja, Vivek Kumar, Radha K. Dhiman, Krishan L. Gupta, Yogesh Chawla
      Abstract: Background and Aim: Patients with End Stage Renal Disease (ESRD) are at greater risk of acquiring chronic hepatitis B or C and development of subsequent liver disease. Aim of the study was to assess the role of transient elastography (TE) for non-invasive assessment of liver fibrosis in patients with ESRD on maintenance hemodialysis (MHD).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.164
      Issue No: Vol. 7 (2017)
       
  • Glycogen Storage Diseases: A Metabolic Disease Presenting With
           Non-metabolic Complications
    • Authors: Madhur Jain; Sajan Agarwal
      Abstract: Background: Glycogen storage diseases (GSDs) are metabolic liver disorders affecting glycogen metabolism. GSDs represent the enzymatic defects in glycogen metabolic pathway predominantly affecting liver, muscle and heart. Individuals with GSD usually presents with characteristic doll-like facies, hepatomegaly, hypoglycemia, hyperlipidemia and growth retardation. However, they may also presents with predominant non-metabolic complications like recurrent infection with or without enterocolitis due to neutropenia and neutrophil dysfunction in GSD Ib and hypophosphatemic rickets due to proximal renal dysfunction in GSD XI.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.163
      Issue No: Vol. 7 (2017)
       
  • Spontaneous Resolution of Post-Traumatic Hepatic Artery Pseudoaneurysm
           Presenting as Hemobilia, Hemocholecystitis and Shock
    • Authors: Sajan Agarwal; Madhur Jain, Raj K. Gupta
      Abstract: Background: Post-traumatic hepatic artery pseudoaneurysm is a rare, but life threatening condition. Symptoms can occur days or even months after the trauma.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.162
      Issue No: Vol. 7 (2017)
       
  • Molecular Diagnosis of Wilson's Disease Using Next Generation Sequencing
           Platform
    • Authors: Rekha Athiyarath; Aaron Chapla, Madeline Vidhya, Ashish Goel, C.E. Eapen, Uday Zachariah, Nihal Thomas, Thomas Paul, Nithin Kapoor
      Abstract: Background and Aim: In patients with hepatic Wilson's disease (WD), confirmatory diagnosis is often elusive. Currently available genetic tools for WD diagnosis are time consuming and expensive. Next generation sequencing (NGS) offers high throughput sample processing at a relatively lower cost. Therefore, we aim to investigate the feasibility of the NGS-based approach to sequence ATP7B gene in patients with hepatic WD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.161
      Issue No: Vol. 7 (2017)
       
  • Clinical Profile of Patients with Simultaneous Presentation of Wilson's
           Disease and Autoimmune Liver Disease in a Rural Tertiary Care Centre
    • Authors: R. Ramasubramanian; Y. Jaipaul, A. Shafique, Poppy Rejoice
      Abstract: Background and Aim: The coexistence of Wilson's disease and autoimmune liver disease in a same patients is a rare entity. In this situation, combined treatment with steroid and D-Penicillamine may be effective.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.160
      Issue No: Vol. 7 (2017)
       
  • Premalignant Mucosal Lesions in Gallbladder is a Rarity in South Indian
           Patients Undergoing Cholecystectomy—A Single Centre Experience
    • Authors: Mayank Jain; V. Vaithiswaran, V.I.J. Mukul, Sruthi Sankar, Tom Michael, Jayanthi Venkataraman
      Abstract: Background and Aim: Gall bladder diseases differ significantly in presentation, symptoms, histopathology and cancer rates in North and South India. The study was aimed to determine the histopathological findings in cholecystectomy specimens and to determine the prevalence of metaplasia and dysplasia in a predominant south Indian cohort.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.159
      Issue No: Vol. 7 (2017)
       
  • Profile of Extrahepatic Portal Vein Obstruction in Coastal Eastern Region
           of Odisha, A Single Center Experience
    • Authors: Girish K. Pati; Haribhakti S. Das, Chittaranjan Panda, Shivaram P. Singh
      Abstract: Background and Aim: Extrahepatic portal venous obstruction (EHPVO) is an important cause of Portal hypertension. There is paucity of data regarding EHPVO in Odisha. Patients of EHPVO diagnosed on USG and Color Doppler study were evaluated for age of presentation, mode of therapy and outcome.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.158
      Issue No: Vol. 7 (2017)
       
  • Diagnostic Dilemmas With Criglernajjartype II (CN II)
    • Authors: Gaurav D. Bachhav; Avinash Balekudru, Kiran Reddiwari, L.V. Lokesh, Bonthala Satyaprakash, S.K. Ravi Kiran
      Abstract: Background: CN II is related to a defect of bilirubin conjugation due to partial deficiency of the enzyme uridine diphosphate-glucuronyl transferase1. In this report, we present 3 diagnostic dilemmas with CN II.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.157
      Issue No: Vol. 7 (2017)
       
  • Hepatic Dysfunction in Pregnancy: Fetal Outcomes and Predictors
    • Authors: Indrajit Suresh; Suryaprakash Kothe, Anurag Lavekar, D. Chandrababu
      Abstract: Background and Aim: Fetal adversities are frequently encountered during pregnancies complicated by liver disease, and these can be prevented by early patient identification and appropriate management strategies. We investigated fetal outcomes, and identified cost effective, reliable maternal investigations, which had good predictive value.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.156
      Issue No: Vol. 7 (2017)
       
  • Clinical Presentation and Management of Hepatic Hydatid Cyst Cases Using
           Percutaneous Aspiration Injection and Reaspiration (PAIR)
    • Authors: Sudhir K. Singh; Vinod K. Dixit, Sunit K. Shukla, Gaurav Garg, Shivam Sachan
      Abstract: Background and Aim: Our aim was to study and evaluate demographic and clinical profile, diagnostic methods and management options, especially PAIR in cases of hepatic hydatid cyst.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.155
      Issue No: Vol. 7 (2017)
       
  • Bouveret Syndrome Missed by a Whisker: A Case Report
    • Authors: Athish Shetty; Avinash Balekuduru, Satyaprakash B. Subbaraj
      Abstract: Background: Gallstones ileus is a rare cause of intestinal obstruction secondary to gall stone causing bilioenteric fistula. The stone commonly lodges in the distal ileum, colon or duodenum and the least common site of obstruction is the proximal duodenum/pylorus causing gastric outlet obstruction (Bouveret's syndrome). We present a case of endoscopic removal of a large gallstone impacted in the first part of duodenum.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.154
      Issue No: Vol. 7 (2017)
       
  • A Novel Model to Predict Tumour Recurrence in Hepatitis B Virus Associated
           Hepatocellular Carcinoma
    • Authors: Gaurav Roy; Atanu Bhattacharjee, Neelanjana Roy, Koushik Dutta, Mudassar Shahid, Mohammad Misbah, Subash Gupta, Mohammad Husain
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies worldwide with hepatitis B virus (HBV) as the most important etiological agent. The outcome of medical management of HBV-related HCC is abysmal and post-transplant tumour recurrence represents a major challenge. However, a robust clinical predictor of disease recurrence is still not established despite several studies illustrating multiple causative factors. In this study, we report a preliminary model that predicted the probability tumour recurrence in patients presenting with HBV-related HCC and opting for living donor liver transplantation (LDLT).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.153
      Issue No: Vol. 7 (2017)
       
  • To Study Plasma sHLA-G Levels of HCC Patients Showing INDEL Polymorphism
           and its Correlation With Response to Locoregional Therapy
    • Authors: Baibaswata Nayak; Renu Yadav, Neeti Nadda, Neelanjana Roy, Shashi Paul, Shalimar
      Abstract: Background and Aim: Human leukocyte antigen-G (HLA-G) is a class I, non-classical major histocompatibility complex molecule that participates in a tumor-driven immune escape mechanism. Ectopic expression of HLA-G is often associated with cancer. Clinical relevance of HLA-G expression and its relation with HLA-G INDEL polymorphism and therapeutic response in hepatocellular carcinoma (HCC) patient is not clear. The study was done to evaluate expression of HLA-G in HCC patients of INDEL polymorphic genotype of responder and non-responder receiving loco-regional therapy.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.152
      Issue No: Vol. 7 (2017)
       
  • Hepatocellular Carcinoma Tumour Size is not Associated With Increased Risk
           of Post-transarterial Chemoembolization Liver Failure
    • Authors: Neeti Nadda; Shalimar, Shekhar Jadaun, Swatantra Gupta, Gyan Raout, Gyan Ranjan, Ashish Aggarwal, Rahul Sethia, Bhaskar Thakur, Saurabh Kedia, Shivanand Gammanagatti, Shashi Paul
      Abstract: Background and Aim: Tumour size >10cm is a relative contraindication for Transarterial Chemoembolization (TACE). In this prospective study, we evaluated the risk of liver failure (LF) and tumour response among hepatocellular carcinoma (HCC) patients undergoing TACE.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.151
      Issue No: Vol. 7 (2017)
       
  • Metastatic Renal Cell Carcinoma With Hepatic Dysfibrinogenemia—A
           Case Report
    • Authors: Rahul D. Arora
      Abstract: Background and Aim: Anaemia and edema have been shown to be poor prognostic factors in advanced malignancy. Thrombocytopenia, functional factor deficiency and accelerated fibrinolysis are possible hepatic causes of abnormal bleeding. Secondary dysfibrinogenemia due to increased fibrinogen sialylation which impairs the ability to form fibrin polymers is seen in advanced liver disease and renal cell carcinoma. Intravenous albumin infusion has been used to prevent paracentesis induced circulatory dysfunction (post LVP) and provide nephroprotection by improving microcirculation.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.150
      Issue No: Vol. 7 (2017)
       
  • Restoration of Microrna-126 Expression Reduces Apoptosis in Hepatitis B
           Virus Infected Hepatocellular Carcinoma Cells
    • Authors: Amit Ghosh; Suchandrima Ghosh, Ankit Chackraborty, Sayantani Bhoumik, Susree Roy, Simanti Datta, Gopal K. Dhali, Abhijit Chowdhury, Soma Banerjee
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is third leading cause of cancer related mortality worldwide. Chronic hepatitis B (CHB) is one of the reasons for HCC development. India has over 40 million chronic HBV infected individuals, but estimation of HCC is grim. The reasons of the under report may be due to its asymptomatic appearance, late detection in the advanced stages and poor awareness. Extrapolating our previous findings of miR-126 as biomarker for HBV related HCC, here we have elucidated the pathophysiological role of overexpressed miR-126 in hepatocarcinogenesis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.149
      Issue No: Vol. 7 (2017)
       
  • To Study Changes in Circulatory Microrna Expression in Hepatocellular
           Carcinoma Patients Receiving Locoregional Therapy and its Correlation With
           Therapeutic Response
    • Authors: Baibaswata Nayak; Neeti Nadda, Sashi Paul, Shalimar, Subrat K. Acharya, Anoop Saraya
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. Major cause of HCC is underlying Hepatitis B virus (HBV). Due to absence of suitable biomarker; therapeutic response to locoregional therapy is mostly assessed by radiological imaging techniques like DPCT or MRI. There is a need to identify a novel diagnostic and prognostic biomarker for HCC. Circulatory miRNAs are considered as potential biomarker due to their ease in detection and high stability in circulation.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.148
      Issue No: Vol. 7 (2017)
       
  • Role of Diffusion Weighted Imaging in Assessment of Tumor Response After
           Loco-regional Therapy in Patients of Hepato-Cellular Carcinoma
    • Authors: Vidyasagar Ramalingam; Ekta Dhamija, Shashi B. Paul, Shivanand Gamanagatti
      Abstract: Background and Aim: Diffusion Weighted Imaging (DWI) has been found to be useful in liver mass characterisation. Its role in post-treatment evaluation has not been adequately explored. While dynamic contrast-enhanced magnetic resonance imaging (DCE—MRI) is the standard of evaluation for post-treatment response, DWI can potentially differentiate between viable and non-viable tissue and hence may be useful. This study was designed to evaluate the sensitivity and specificity of DWI in response assessment after loco-regional therapy for HCC.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.147
      Issue No: Vol. 7 (2017)
       
  • Utility of Lipiodol CT for Treating Small Hepatocellular Carcinoma
    • Authors: Shashi B. Paul; R. Vidyasagar, Ekta Dhamija, Shivanand R. Gamanagatti, S. Shalimar, Subrat K. Acharya
      Abstract: Background and Aim: In the past, use of Lipiodol Computerized Tomograhy (CT) has shown high sensitivity in detecting small intrahepatic nodules for preoperative staging. Technique involves an intra-arterial injection of iodized oil (lipiodol) through the hepatic arterial supply following which lipiodol gets deposited within the malignant liver nodule (HCC). This HCC is seen as a hyperattentuating (radiodense) nodule on subsequent CT. We illustrate two representative cases of small HCC (diagnosed on MRI, not seen on ultrasound/CT) that were managed successfully with the use of this technique.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.146
      Issue No: Vol. 7 (2017)
       
  • Radiological Management of Hepatocellular Carcinoma Associated With
           Hepatic Venous Outflow Tract Obstruction
    • Authors: Shashi B. Paul; Ekta Dhamija, R. Vidyasagar, Shivanand R. Gamanagatti, S. Shalimar, Subrat K. Acharya
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) associated with hepatic venous outflow tract obstruction (HVOTO) is an unusual entity which has recently gained recognition. Treatment of both entities is essential in prolonging survival. Interventional radiologic techniques are the established therapeutic options for HVOTO and HCC and thus treatment becomes challenging. We illustrate two representative cases treated successfully treated at our centre.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.145
      Issue No: Vol. 7 (2017)
       
  • Outcomes of Transarterial Chemoembolization in Patients of
           Alpha-Fetoprotein Secreting Hepatocellular Carcinoma
    • Authors: Shashi B. Paul; Vishnubhatla Sreenivas, Shivanand R. Gamanagatti, Shekhar Singh, R. Vidyasagar, Ekta Dhamija, Neeti Nadda, S. Shalimar, Subrat K. Acharya
      Abstract: Background and Aim: Hepatocelluar carcimona (HCC) is the fifth most common malignant tumor worldwide and the third most frequent cause of cancer-related death globally. Large proportion of patients has advanced disease at outset for which transarterial chemoembolization (TACE) is the recommended therapy. Alpha-fetoprotein (AFP) is the biomarker for HCC and about 70% of HCC patients has AFP secreting tumors. This study was designed to evaluate the outcome of TACE in AFP secreting HCC patients in comparison with patients of the non-AFP secreting HCC.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.144
      Issue No: Vol. 7 (2017)
       
  • Infantile Hemangioendothelioma Presenting as Neonatal Cholestasis
           Syndrome: An Uncommon Presentation of a Very Rare Cause
    • Authors: Sajan Agarwal; Madhur Jain, Raj K. Gupta
      Abstract: Case Summary: 30-day-old female baby, born by full term delivery, admitted with complaints of noticed yellowish discoloration of eye and urine for last 15 days with diaper staining and ambiguous stool. On examination, baby had deep icterus with hemangioma like lesion over anterior abdominal wall and firm hepatosplenomegaly. In work up, there was severe anemia with thrombocytopenia and LFT showed high conjugated hyperbilirubinemia with high GGT. USG abdomen showed multiple hypoechoic lesion with hyperechoic rim (largest lesion 22mm×13mm) noted in both lobes of liver and portal vein thrombosis with lesion communicating with left portal vein.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.143
      Issue No: Vol. 7 (2017)
       
  • Predictive Factors Determining Survival in Ambulatory Cirrhotic HCC
           Patients & Survival Analysis Using ALBI & Child Score
    • Authors: Aniruddha P. Haripal Singh; Krishnadas Devadas, Srijaya Sreesh, Gaurav Kapur, Varun Tadkalkar, Rathan C. Joseph, Neehar Shanavas
      Abstract: Background and Aim: Identifying accurate prognostic indicators of overall survival (OS) in Hepatocellular carcinoma (HCC) allows care provider to counsel Individual patients and utilize optimum resources. In this study we aim to find out predictive factors determining survival in ambulatory cirrhotic HCC patients & further assess survival using ALBI & CHILD Score.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.142
      Issue No: Vol. 7 (2017)
       
  • Two Uncommon Metastasis of Hepatocellular Carcinoma—A Case Report
    • Authors: Sanjeev Nagaruru; Avinash Balekudru, Kiran Reddiwari, L.V. Lokesh, B.S. Satyaprakash, Ravi Kiran
      Abstract: Background: Hepatocellular carcinoma (HCC) constitutes more than 90% of primary liver cancers and extra hepatic spread are to lung, lymph nodes, bones and adrenals in decreasing order. We report 2 rare cases of metastatic HCC one each to peritoneum and stomach presenting with abdominal mass and gastrointestinal bleeding.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.141
      Issue No: Vol. 7 (2017)
       
  • Endoscopic Ultrasound (EUS) Can Help in the Etiological Evaluation of Low
           Serum Ascites Albumin Gradient (SAAG) High Protein Ascites
    • Authors: Athish Shetty; Avinash Balekuduru, Kiran Reddyvari, Lokesh Locheruvapalli, Ravi K. Sk, Satyaprakash B. Subbaraj
      Abstract: Background and Aim: Endoscopic ultrasound (EUS) and EUS—fine needle aspiration (FNA) has been established as an important modality for staging gastrointestinal malignancies.1 We report two cases of low SAAG high protein ascites and utility of EUS in determining the diagnosis of ascites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.140
      Issue No: Vol. 7 (2017)
       
  • Cytotoxic and Apoptotic Effects of Acacia catechu in Hepatocellular
           Carcinoma HepG2 Cells
    • Authors: Ezhilarasan Devaraj; T. Lakshmi
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is the fifth most common cancer. Acacia catechu is commonly known as catechu and it contains rich source of catechin, epicatechin, and flavonoids. The objective of this study was to evaluate the cytotoxicity of A. catechu ethanolic seed (ACS) extract in HCC HepG2 cell line.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.139
      Issue No: Vol. 7 (2017)
       
  • A Rare Case Presenting for Liver Transplant
    • Authors: Deven Gosavi; A.R. Venkateswaran, M.S. Revathy, M. Malarvizhi, S. Chitra, R. Murali, M. Manimaran, Hardik Rughwani
      Abstract: Background: Hereditary transthyretin amyloidosis is a rare worldwide autosomal dominant disease caused by the systemic deposition of an amyloidogenic variant of TTR. More than 100 mutations in the TTR gene have been described. Each variant has a different involvement although cardiomyopathy and neuropathy are the most common presentations. Orthotopic liver transplantation is a definitive treatment for this condition as the liver is the source of the mutant protein. OLT replaces the liver producing the mutant protein with one producing the normal wild type variant of the protein thus arresting the progress of the condition.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.138
      Issue No: Vol. 7 (2017)
       
  • Study of MELD Models (MELD Score, MELD Sodium, iMELD, MESO) in Predicting
           the Short Term (3 Months) Mortality in Chronic Liver Disease Patients
           Awaiting for Liver Transplantation
    • Authors: G.S. Gurudath; Mohammad J. Khan, T.S.R. Kumar, Khalid J. Bhat, G.S. Sharathkote, Chinnusamy Palanivelu
      Abstract: Background and Aim: Though MELD score is well authenticated for predicting short term mortality, there are many pitfalls in it. Many attempts have been made to improvise the model by incorporation of serum sodium (MELD sodium), age and sodium (iMELD). With this background, the present study was conducted in our South Indian population with an intention of determining the accuracy among MELD derived models (i.e., MELD sodium) in predicting the short-term mortality. The study was done to determine the predictors of short-term mortality using MELD models and laboratory parameters, to compare the accuracy among MELD models in predicting the short term (3 months) mortality.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.137
      Issue No: Vol. 7 (2017)
       
  • A Retrospective Analysis of Explant Liver Pathology: Experience from A
           Tertiary Care Center in India
    • Authors: Nalini Bansal
      Abstract: Background and Aim: The histological spectrum of explant liver pathology and their prevalence has rarely been reported from Indian subcontinent. The study was performed to provide new insight into the prevalence of explant liver pathologies in this part of world by retrospective analysis of spectrum of histological changes. Secondly, to study etiopathological association of cirrhosis and third to study the etiopathogenesis for development of hepatocellular carcinoma and to analyze whether there is any association of macro regenerative and dysplastic nodule with hepatocellular carcinoma.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.136
      Issue No: Vol. 7 (2017)
       
  • Living Donor Liver Transplantation for Severe Alcoholic Hepatitis Not
           Responding to Medical Management: An Experience of 31 Patients
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Dheeraj Gautam, Nerraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Arvinder S. Soin
      Abstract: Background and Aim: There is limited data on outcomes of living donor liver transplantation (LDLT) for alcoholic hepatitis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.135
      Issue No: Vol. 7 (2017)
       
  • Lactulose Acceptance Varies Between Indian and American Cirrhotic
           Patients: Implications for Comparing, Designing and Interpreting Global
           Hepatic Encephalopathy Trials
    • Authors: Sahaj Rathi; Andrew Fagan, Madhu Chopra, James Wade, Melanie White, Dinesh Ganapathy, Radha K. Dhiman, Jasmohan S. Bajaj
      Abstract: Background and Aim: Lactulose is considered first-line for hepatic encephalopathy, but adherence differs among Western and Eastern studies. Patient preference for lactulose in different continents has not been studied systematically. We aimed to define using a discrete choice questionnaire (DCQ), the preference and reasons behind acceptance and rejection of lactulose in cirrhotics from USA and India.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.134
      Issue No: Vol. 7 (2017)
       
  • Randomized Control Trial of Rifaximin and Norfloxacin in Primary and
           Secondary Prophylaxis of Spontaneous Bacterial Peritonitis (SBP) in
           Cirrhotic Patients
    • Authors: Dibyalochan Praharaj; Sunil Taneja, Ajay Duseja, Y.K. Chawla, Radha K. Dhiman
      Abstract: Background and Aim: Spontaneous bacterial peritonitis (SBP) is a life threatening infection in patients with cirrhosis. Patients with advanced cirrhosis and prior history of SBP have a high risk of developing SBP for which they need either primary or secondary prophylaxis respectively. Norfloxacin has been used extensively for SBP prophylaxis since decades which has led to increase in incidence of SBP on prophylaxis and SBP related to gram positive organisms. Thus alternative oral antibiotic must be used to prevent this life threatening complication in cirrhotic patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.133
      Issue No: Vol. 7 (2017)
       
  • Presence of Multidrug Resistant Infections Predict 28-Day Mortality in
           Acute Decompensation of Cirrhosis
    • Authors: Tarana Gupta; Dibyaochan Praharaj, Sahaj Rathi, Swastik Agrawal, A. Duseja, Sunil Taneja, Yogesh K. Chawla, Radha K. Dhiman
      Abstract: Background and Aim: Infections are the most common cause of acute decompensation of cirrhosis. We studied incidence of bacterial infections in acute decompensation, pathogens involved and their impact on prognosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.132
      Issue No: Vol. 7 (2017)
       
  • Urinary Neutrophil Gelatinase Associated Lipocalcin—A Novel Diagnostic
           and Prognostic Biomarker of Hours in Acute Kidney Injury in Cirrhosis
    • Authors: Suhas Udgirkar; Sanjay Chandnani, Vinay Pawar, Vinay Zanwar, Ravindra Surude, Samit Jain, Qais Contractor, Pravin Rathi
      Abstract: Background and Aim: Acute kidney injury (AKI) is prone to increase mortality in patients with cirrhosis. Identification of kidney failure etiology and recognition of those at the highest mortality risk remains a challenge. We aimed to determine an accuracy of uNGAL for diagnosing HRS in cirrhosis and association in predicting mortality at 30 days in AKI in cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.131
      Issue No: Vol. 7 (2017)
       
  • Slow, Continuous Low-Dose Albumin and Furosemide Infusion (SCLAFI)
           With/Without Terlipressin Mobilizes Refractory Ascites Safely in
           Decompensated Liver Cirrhosis
    • Authors: Gaurav Pandey; Kamlesh Kumar, V.P. Krishna, Prabhat N. Sharma, Manjunath, Alok Kumar, Hemant K. Nayak, Samir Mohindra, Vivek Saraswat
      Abstract: Background and Aim: Graded increase of oral diuretics has been the standard therapy for mobilizing large ascites in decompensated liver cirrhosis. Large volume paracentesis (LVP) with or without albumin infusions has been the commonest rescue therapy. Both are sought with complications. The study was done to study the efficacy and safety of low-dose, continuous, infusion of furosemide with albumin, administered according to a response-guided protocol in patients with cirrhosis and large ascites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.130
      Issue No: Vol. 7 (2017)
       
  • Non-Hepatic Surgery in Patients With Liver Cirrhosis: Is the Nihilism
           Warranted'
    • Authors: Abhishek Yadav; H. Ramesh, S. Mahesh, V. Lekha, S. Waliullah
      Abstract: Background and Aim: Patients with liver cirrhosis (LC) frequently require non hepatic abdominal surgery. Surgery in these patients is looked at nihilistically even today. We aimed to analyze our experience of non-hepatic surgery in patients with LC in respect to the morbidity and mortality and try and identify the factors which affect the outcomes in this group of patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.129
      Issue No: Vol. 7 (2017)
       
  • Minimal Hepatic Encephalopathy in Ethanol and Non-Alcoholic
           Steatohepatitis Related Cirrhosis
    • Authors: Pintu Bhakhar; P.N. Rao, Nitin Jagtap, Mithun Sharma, D.N. Reddy
      Abstract: Background and Aim: Being neurotoxin, ethanol may have additional neurotoxicity in the patients with ethanol related cirrhosis. This study aimed to evaluate frequency of minimal hepatic encephalopathy (MHE) in patient's ethanol and non-alcoholic steatohepatitis (NASH) related cirrhosis along with comparison of critical flicker frequency (CFF) in both groups
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.128
      Issue No: Vol. 7 (2017)
       
  • Prevalence and Pattern of Spontaneous Bacterial Peritonitis (SBP) Its
           Microbiological Profile and Its Comparison With Non-SBP in CLD Patients
    • Authors: Dheeraj Jeswani; Goldie Longjam
      Abstract: Background and Aim: Spontaneous bacterial peritonitis (SBP) is the most common infection of ascitic fluid that occurs in about 10–30% of patients with ascites, mortality rates due to SBP to be as high as 80–90%, but this can be decreased to 20–40% with early diagnosis and effective therapy with broad-spectrum antibiotics. The study was done to evaluate the microbiological profile with sensitivity pattern to aid in empiric therapy and various other correlations.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.127
      Issue No: Vol. 7 (2017)
       
  • HAV IgG Status in Cirrhotic in A Tertiary Care Setup Coastal Region of
           South East India
    • Authors: Srinivas Nistala
      Abstract: Background and Aim: The natural history of a cirrhotic patient can be altered by many factors both external and internal like bleeding, SBP, superimposed viral infections etc. Vaccination can prevent superimposed acute hepatitis B and hepatitis A. Studies in the past have shown that persons beyond 15 years of age in the general population in Indian subcontinent are already immune to hepatitis A, it is not recommended to vaccinate Indian cirrhotic with hepatitis A vaccine as a routine unlike recommendation from the west.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.126
      Issue No: Vol. 7 (2017)
       
  • A Comparative Study of Caregiver Burden in Alcoholic Liver Disease and
           Nonalcoholic Fatty Liver Disease
    • Authors: Murali K. Mankulangara; Thazath M. Ramachandran
      Abstract: Background and Aim: Cirrhosis of liver, like any other chronic disease increases the socioeconomic and emotional burden on the caregiver. Adherence to therapy and follow-up depends up on the caregiver's physical and mental status. But the problems of caregivers are under recognized. In this background we decided to study the caregiver burden of two groups of cirrhotic patients—alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.125
      Issue No: Vol. 7 (2017)
       
  • The Microbiological Profile of Spontaneous Ascitic Fluid
           Infection—Should Our First Hit Be Harder'
    • Authors: Zohaib A.W. Khan; Shiran Shetty, Ganesh Pai, Girisha Balaraju, B.R. Abhijit, Shabeer Ahamed, Vandana Ke
      Abstract: Background and Aim: Spontaneous ascitic fluid infection (SAI) is common in cirrhotics leading to significant morbidity and mortality. Third-generation cephalosporins are currently recommended as first-line therapy. We conducted a retrospective study to determine the bacterial aetiology and susceptibility patterns in SAIs among cirrhotic patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.124
      Issue No: Vol. 7 (2017)
       
  • Usefulness of Aim 65 Scoring System in Predicting Rebleed and Prognosis
           Portal Hypertensive Bleed Patients With Underlying Cirrhosis
    • Authors: Amol S. Dahale; Ajay Kumar, Siddhartha Srivastav, Shivakumar Varakanahalli, Sanjeev Sachdeva, Amarender S. Puri
      Abstract: Background and Aim: Prognosis and rebleed prediction of upper gastrointestinal bleed (UGIB) in chronic liver disease (CLD) patients with portal hypertension (PHTN) is difficult task. We aimed to study usefulness of AIM 65 scoring system in these patients to predict outcome of bleed in Indian setup.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.123
      Issue No: Vol. 7 (2017)
       
  • Very Early (
    • Authors: Rohan R. Badave; Vishwanath Tantry, Sandeep Gopal, Suresh Shenoy, Anurag Shetty
      Abstract: Background and Aim: In cirrhotic patients, bleeding episodes are associated with significant mortality and morbidity. This study aim at evaluating outcomes of very early (
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.122
      Issue No: Vol. 7 (2017)
       
  • Ascitic Fluid Culture After Centrifugation in Children With Liver Disease:
           Is It Better Than Routine Bedside Method'
    • Authors: Sumit K. Singh; Ujjal Poddar, Richa Mishra, Anshu Srivastava, Surender K. Yachha
      Abstract: Background and Aim: Culture positivity rate (yield) of ascitic fluid infection (AFI) in children by has been found below 50%. Centrifugation of peritoneal fluid dialysate prior to culture has been shown to improve the yield. Our aim was to find if centrifugation increases the yield of ascitic fluid culture also.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.121
      Issue No: Vol. 7 (2017)
       
  • Prevalence of Renal Dysfunction in Critically Ill Cirrhotic Patients
           According to Revised Consensus Recommendations of the International Club
           of Ascites
    • Authors: Rishabh Jain; Y. Raghavendra, Naina Joshi, B. Sukanya, C. Ravichandra, C. Vineet, Ajit Kumar
      Abstract: Background and Aim: Cirrhotic patients with acute renal failure admitted to intensive care units (ICUs) have high mortality rates. To determine the prevalence, cause, and outcome of critically ill patients with cirrhosis and acute kidney injury (AKI).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.120
      Issue No: Vol. 7 (2017)
       
  • Ayurvedic Management of Hepatic Cirrhosis With Complication: Case Studies
    • Authors: Ashok Panda
      Abstract: Background: Hepatic cirrhosis, very often diagnosed when complicated with Jaundice, ascites, pedal oedema and encephalopathy. Its conventional management involves high cost medicine and procedures. Liver transplantation is the treatment option in many advance cases. Common patient cannot bear the cost and out of fear came for Ayurveda treatment. Its 10 year mortality is 34–60%, 15% patients with ascites die within first 12 months and 44% within the first five years. Yakruit suska and Jalodara can be interpreted as hepatic cirrhosis with complication.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.119
      Issue No: Vol. 7 (2017)
       
  • SOCS1-Dependent Regulation of the Hepatic Fibrogenic Response
    • Authors: Rajani Kandhi; Euphrasie K. Mafanda, Christoph Osterreicher, Subburaj Ilangumaran
      Abstract: Background and Aim: Liver fibrosis (LF) is a consequence of chronic inflammation, characterized by excess deposition of abnormal extracellular matrix (ECM). Unchecked LF leads to cirrhosis and hepatocellular carcinoma, important causes of global mortality. Previously we have shown that mice lacking Suppressor of Cytokine Signaling 1 (SOCS1) show increased LF, accompanied by activation of hepatic stellate cells (HSC), a key player in hepatic fibrogenesis. Here we investigated whether the loss of SOCS1 in HSC alone is sufficient to promote LF, or SOCS1 deficiency in hepatocytes or macrophages are also necessary for LF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.118
      Issue No: Vol. 7 (2017)
       
  • Helicobacter Pylori Infection in Patients WITH Portal Hypertensive
           Gastropathy Owing to Liver Cirrhosis—Prevalence and Relation With
           Disease Severity: A Study From Tertiary Care Centre in North India
    • Authors: Shekhar Puri; Mukesh Jain
      Abstract: Background and Aim: Helicobacter pylori is major human pathogen. Its role in pathogenesis of PHG is debated. The aim of this study was to evaluate prevalence of this infection in patients with portal hypertension due to liver cirrhosis, and its relation with disease severity.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.117
      Issue No: Vol. 7 (2017)
       
  • Prevalence of Malnutrition Across Varying Severity of Cirrhosis Is
           Associated With Dietary Insufficiency
    • Authors: Shraddha Salunkhe; Meena Godhia, Abhinav Jain, Akash Shukla, Shobna Bhatia
      Abstract: Background and Aim: Malnutrition is prevalent in cirrhosis and associated with increased number of complications and increased short and long term mortality. Diminished nutrient intake and self imposed dietary restrictions contribute to malnutrition in this population.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.116
      Issue No: Vol. 7 (2017)
       
  • Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis: A Double
           Blind Randomized Controlled Trial of l-Ornithine l-Aspartate Vs Placebo
    • Authors: Shivakumar Varakanahalli; Barjesh C. Sharma, Amol S. Dahale
      Abstract: Background and Aim: Hepatic encephalopathy is associated with a poor prognosis. l-Ornithine l-aspartate has been useful in treatment of hepatic encephalopathy. There is no study on the prevention of recurrence of encephalopathy with l-ornithine l-aspartate.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.115
      Issue No: Vol. 7 (2017)
       
  • To Assess Outcome of Slow Low-Dose Continuous Albumin,
           Furosemide±Terlipressin Sifa (±T) Infusion in Patients of Cirrhosis With
           Hepatic Hydrothorax
    • Authors: Manjunath Hatti; Kamlesh Kumar, Alok Kumar, Gaurav Pande, V.P. Krishna, Prabhat N. Sharma, Vivek Saraswat
      Abstract: Background and Aim: Management of hepatic hydrothorax is challenging in view of limited treatment options specially medical management. The study was done to assess efficacy and safety of SIFA (±T) as a response-guided protocol in patients of cirrhosis with hydrothorax.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.114
      Issue No: Vol. 7 (2017)
       
  • To Study the Prevalence of Minimal Hepatic Encephalopathy in Cirrhosis of
           Liver by Psychometric Analysis
    • Authors: A. Keerthi; P.S. Kumar, M. Umadevi
      Abstract: Background and Aim: MHE is associated with significant impaired in health-related quality of life, ability to drive, predicts the development of overt HE and is associated with poor survival. Hence, screening of all patients with cirrhosis for MHE using psychometric tests, and treatment of those patients diagnosed to have MHE has been recommended. The study was done to assess the prevalence of minimal hepatic encephalopathy in cirrhosis of liver by psychometric analysis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.113
      Issue No: Vol. 7 (2017)
       
  • Rate of Coexisting Esophageal Varices and Peptic Ulcer in Patients With
           Cirrhosis of Liver
    • Authors: Ahmed L. Moben; Jahangir Kabir, Farjana Majid, Mamun A. Mahtab, Noor E. Alam
      Abstract: Background and Aim: Hematemesis in cirrhosis of liver patients sometimes raise a question whether it is from rupture varices or from bleeding peptic ulcer disease. This study has been done to make an understanding about this issue among those centers where endoscopy facilities are not available in Bangladesh.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.112
      Issue No: Vol. 7 (2017)
       
  • Study of Clinical Profile of Metabolic Bone Diseases in Liver Cirrhosis in
           Central India
    • Authors: Sandeep H. Kaulavkar; Ajay K. Jain, Suchita Jain
      Abstract: Background and Aim: Metabolic bone disorders also known as hepatic osteodystrophy (HOD) are well-recognized extra hepatic complication of cirrhosis. There are very scanty data on the prevalence of metabolic bone disease in the Indian population. We aimed to determine the prevalence of metabolic bone disease in patients with liver cirrhosis and to study the factors associated with it along with impact of calcium and vitamin D on bone mineral density (BMD) in patients with liver cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.111
      Issue No: Vol. 7 (2017)
       
  • Assessment of Depression in Patients With Cirrhosis of Liver
    • Authors: A. Anand; Caroline Selvi
      Abstract: Background and Aim: To determine whether patients with cirrhosis and depressive symptoms have a different neuropsychological cognitive profile from patients with cirrhosis without depressive symptoms.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.110
      Issue No: Vol. 7 (2017)
       
  • Modification of Deranged Systemic Hemodynamic Parameters With Slow
           Infusion of Furosemide and Albumin With or Without Terlipressin in
           Patients With Refractory Ascites
    • Authors: Prabhatnarain Sharma; V.P. Krishna, Gaurav Pande, Alok Sharma, Vivek A. Saraswat
      Abstract: Background and Aim: Hyperdynamic circulation, splanchnic vasodilation, impaired intestinal permeability prevent ascites mobilisation. Assess safety and efficacy of slow infusion of furosemide and albumin with/without terlipressin SIFA(T) in patients with refractory ascites.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.109
      Issue No: Vol. 7 (2017)
       
  • Vitamin D As A Predictor of Severity in Patients With Cirrhosis of Liver
    • Authors: V. Gopalakrishna; P.S. Kumar, Umadevi
      Abstract: Background: In patients with chronic liver diseases, the prevalence of vitamin D deficits is much higher and practically universal. Vitamin D deficiency has been associated with increased mortality, bacterial infections, portal hypertension complications and fibrosis severity. The study was done to assess the relation of vitamin D deficiency to the severity in patients with liver cirrhosis as evidenced by CTP and MELD score.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.108
      Issue No: Vol. 7 (2017)
       
  • Utility of Plasma Von Willebrand Factor in Cirrhosis of Liver as a
           Predictor of Esophageal Varices and Decompensation
    • Authors: Gaurav T. Ratnaparkhi; Ajit Kumar, B. Sukanya, Y. Raghavendra, Nayana Joshi
      Abstract: Background and Aim: Endothelial dysfunction is considered as an important determinant of increased intrahepatic vascular resistance in cirrhosis of liver. Von Willebrand factor (vWF) is released by activated endothelial cells and plays a crucial role in the development of portal hypertension. The study was done to find out whether plasma Von Willebrand factor predicts the presence of esophageal varices and its correlation with different grades of esophageal varices as well as decompensation.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.107
      Issue No: Vol. 7 (2017)
       
  • Assessment of Malnutrition by Anthropometric Methods and Their Correlation
           With Outcome in Patients With Cirrhosis of Liver
    • Authors: Rajendra Gunjal; Varun Tadkalkar, S. Shanid, K. Sandesh, Krishnadas Devdas
      Abstract: Background and Aim: Malnutrition is a quite common but frequently overlooked problem among patients with cirrhosis of liver. Malnourished cirrhotic patients have a higher rate of complications and an overall increased mortality. This study compared anthropometric methods of assessing malnutrition in cirrhotics and correlated with clinical outcome.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.106
      Issue No: Vol. 7 (2017)
       
  • Spectrum of Bacterial Infections in Cirrhosis of Liver in A Resource
           Constrained Region
    • Authors: Subhendu Panigrahi; Kaibalya R. Das, Preetam Nath, Jimmy Narayan, Prasant K. Parida, Sambit K. Behera, Suryakant Parida, Debakanta Mishra, Chittaranjan Khatua, Shivaram P. Singh
      Abstract: Background and Aim: Patients with cirrhosis of liver are predisposed to bacterial infections and sepsis. Data on bacterial infections in cirrhosis of liver from India are scarce. The aim of this study was to study the spectrum of bacterial infections in hospitalized patients with cirrhosis of liver.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.105
      Issue No: Vol. 7 (2017)
       
  • Necrotizing Fasciitis in Cirrhosis—Predictors of Mortality
    • Authors: Rony Thomas; Deepak Johnson, George C. Matteethra
      Abstract: Background and Aim: Cirrhosis is associated with increase risk of infections resulting in sepsis and sepsis related mortality. Skin and soft tissue infection accounts for only minority of infections. However necrotizing fasciitis, a rare soft tissue infection manifesting as necrosis of skin tissue, is associated with a high mortality rate in cirrhosis. The study was done to assess the risk factors and the predictors of mortality in necrotizing fasciitis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.104
      Issue No: Vol. 7 (2017)
       
  • l-Ornithine l-Aspartate in Acute Overt Hepatic Encephalopathy
    • Authors: Sandeep S. Sidhu; Barjesh C. Sharma, Omesh Goyal, Harsh Kishore, Navpreet Kaur
      Abstract: Background and Aim: High quality data on efficacy of l-ornithine l-aspartate (LOLA) in cirrhotics with acute overt hepatic encephalopathy (HE) is missing. We aimed to evaluate the efficacy of intravenous LOLA in reversal of acute overt HE in cirrhotics. This prospective double-blind randomized placebo controlled trial was conducted at Gastroenterology department of two tertiary care institutes in India.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.103
      Issue No: Vol. 7 (2017)
       
  • Periscreen Strip Test—Rapid Diagnosis of Spontaneous Bacterial
           Peritonitis
    • Authors: Dinesh Jothimani; Ezhil Arasan, Vaibhav Patil, Mohamed Rela
      Abstract: Background and Aim: Delay in the diagnosis of spontaneous bacterial peritonitis (SBP) is associated with significant morbidity and mortality. Conventional diagnosis of SBP is based on the presence of ascitic fluid white cell count (WCC)≥500cells/mm3 or absolute neutrophil count (ANC)≥250cells/mm3. Periscreen (Serim Research Corp, USA) is a new reagent strip specifically designed to test leukocyte esterase activity, an enzyme released by activated neutrophils.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.102
      Issue No: Vol. 7 (2017)
       
  • Xeroderma Pigmentosum Group D Polymorphism in Association With Aflatoxin
           B1 Exposure in Chronic Liver Disease
    • Authors: Wasifa Parween; Anup K. Das
      Abstract: Background and Aim: To analyze total aflatoxin content in various indigenous food consumed by general population and chronic liver disease patients from Assam, India. This was correlated with the polymorphism of xeroderma pigmentosum complementation group D (XPD) codon 312 and 751 (namely Asp312Asn and Lys751Gln), involved in nucleotide excision repair. The study was done to assess the polymorphisms of xeroderma pigmentosum complementation group D in chronic liver disease patients (CLD) and healthy individuals.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.101
      Issue No: Vol. 7 (2017)
       
  • Predictors of 1-Month and 3-Months Hospital Readmissions in Decompensated
           Cirrhosis in India
    • Authors: Ruchir Patel; Mamata S. Lotlikar
      Abstract: Background and Aim: Considered as a healthcare quality indicator, hospital readmissions in decompensated cirrhosis predispose the patients and the society to physical, social and economic distresses. Few studies involving North American cohorts have identified different predictors. The aim of this study was to determine and validate the predictors of 1-month and 3-months readmission in an Indian cohort.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.100
      Issue No: Vol. 7 (2017)
       
  • Factors Predicting Short-Term Mortality in Cirrhotic Patients With
           Infections Other Than Spontaneous Bacterial Peritonitis
    • Authors: Varun R. Tadkalkar; Rajendra Gunjal, G. Ponnikrishnan, Aniruddha P. Singh, Gaurav Kapur, Rathan Joseph, N. Sandeep, S. Sreejaya, Krishnadas Devadas
      Abstract: Background and Aim: Infections other than SBP represent more than two thirds of the infections in patients with cirrhosis. This study was aimed at assessing risk factors for short-term mortality among cirrhotic patients having non-SBP infections.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.099
      Issue No: Vol. 7 (2017)
       
  • A Rare Case of Non-O1, Non-O139 Vibrio Cholera Bacteraemia Causing Hepatic
           Encephalopathy in Cirrhotic Patient
    • Authors: Pallav Parikh; P. Piramanayagam, K.R. Palaniswamy, A.T. Mohan, Usha Srinivas, N. Murugan, Sarojini Parameswaran, Ubal Dhus, M. Hariharan, Seshadri Venkatesh, Preethi Mahalingam
      Abstract: Background: Vibrio cholera serogroups O1 or O139 are the aetiological agents of cholera. The pathogenicity of non-O1, non-O139 Vibrio cholera (NOVC) is less well known. NOVC bacteria are responsible for gastrointestinal infections or, more rarely, bacteraemia in patients with an underlying disease, leading to life-threatening complications.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.098
      Issue No: Vol. 7 (2017)
       
  • Are We Missing Early Primary Biliary Cirrhosis'
    • Authors: Pallavi Bhuyan; Kaumudi Pattnaik, Bidyut Das, Rina Tripathy
      Abstract: Background and Aim: Primary biliary cirrhosis (PBC) is a cholestatic autoimmune liver disease characterized by destruction of medium-sized intrahepatic bile ducts. It is associated with presence of antimitochondrial antibody in 95% cases. Fatigue and pruritus are most common presenting features. Coexistence of PBC with other autoimmune diseases has been documented, with strongest association with rheumatoid arthritis, CREST syndrome, SLE, dermatomyositis and autoimmune thyroiditis. Rheumatologic manifestations are reported in 4–50% of patients with PBC.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.097
      Issue No: Vol. 7 (2017)
       
  • Chronic Autoimmune Hepatitis With Chronic Ulcerative Colitis in a Young
           Boy—A Rare Entity
    • Authors: Apurva S. Shah; Shravan Bohra
      Abstract: Background: Chronic ulcerative colitis in patients with autoimmune hepatitis is rare and poorly described in the literature.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.096
      Issue No: Vol. 7 (2017)
       
  • A Study of Acute Kidney Injury (AKI) in Hospitalised Chronic Liver Disease
           (CLD) Patients: A Single Centre Experience
    • Authors: Chitta R. Khatua; Preetam Nath, Debakanta Mishra, Prasant K. Parida, Sambit K. Behera, Suryakanta Parida, Kaibalya R. Dash, Subhendu Panigrahi, Shivaram P. Singh
      Abstract: Background and Aim: Acute kidney injury (AKI) is a common complication of chronic liver disease (CLD). We performed a prospective study to evaluate the spectrum of renal injury among hospitalised decompensated cirrhosis (DC) patients and their impact on survival.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.095
      Issue No: Vol. 7 (2017)
       
  • Maintenance Zinc Therapy After Initial Penicillamine Chelation to Treat
           Symptomatic Hepatic Wilson's Disease in Resource Constrained Setting
    • Authors: Piyush Gupta; Mehul Choksi, Ashish Goel, Uday Zachariah, K.G. Sajith, Jeyamani Ramachandran, George Chandy, George Kurian, C.E. Eapen
      Abstract: Background and Aim: Experience with zinc in treating symptomatic hepatic Wilson's disease (WD) is limited. The study was done to evaluate the efficacy of penicillamine followed by zinc in treating symptomatic hepatic Wilson's disease.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.094
      Issue No: Vol. 7 (2017)
       
  • Impact of AKI on Mortality and Complications in Cirrhosis
    • Authors: Amit H. Shejal; Varghese Thomas
      Abstract: Background and Aim: Acute kidney injury (AKI) is a common and devastating complication in patients with cirrhosis. It occurs in 20% of patients with cirrhosis admitted to hospital. Creatinine-based criteria for defining acute kidney injury (AKI) are validated in general hospitalized patients but their application to cirrhotic is less certain. We aimed to evaluate current definition of AKI by international club of ascites and assess hospitalized cirrhosis patients with AKI to understand the natural history, clinical course and recovery patterns of the disease and to study the impact of AKI on mortality.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.093
      Issue No: Vol. 7 (2017)
       
  • Prevalence of Cirrhosis Related Complications and Their Impact on Survival
    • Authors: Joy Varghese; Mayank Jain, Uday Sanglodkar, Vijaya Srinivasan, Jayanthi Venkataraman
      Abstract: Background and Aim: Patients with liver cirrhosis are predisposed to recurrent cirrhosis related complications (CRC) including bacterial infection. The study was done to assess the variety of CRC encountered in patients with liver cirrhosis during successive admissions during a follow up of 3 years and to ascertain their impact on survival.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.092
      Issue No: Vol. 7 (2017)
       
  • Scoring Systems That Predict Mortality at Admission in End-Stage Liver
           Disease
    • Authors: Neeraj Mangla; Mayank Jain, Ravi Patel, Jayanthi Venkataraman, Joy Varghese
      Abstract: Background and Aim: Various scoring systems have been developed to assess the severity and prognosticating the survival in end stage liver disease. However, comparative utility of these scoring systems to predict survival in ESLD patients has not been studied. The study was done to compare and analyze the efficacy of scoring systems in predicting mortality in ESLD patients who present with cirrhosis specific complications to the emergency room.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.091
      Issue No: Vol. 7 (2017)
       
  • Lactose Intolerance in Minimal Hepatic Encephalopathy
    • Authors: Satyavati Rana; Radha K. Dhiman, Y.K. Chawla
      Abstract: Background and Aim: Minimal hepatic encephalopathy (MHE) is earliest form of hepatic encephalopathy and can affect up to 80% of patients with liver cirrhosis. Patients with advanced liver disease often face difficulties in maintaining proper nutritional balance. Many factors are involved in their poor nutrition, including poor dietary absorption due to villous atrophy. This may result in decreased lactase activity causing lactose intolerance. This study was done to evaluate the incidence of lactose intolerance in patients of minimal hepatic encephalopathy.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.090
      Issue No: Vol. 7 (2017)
       
  • Translation and Validation of Chronic Liver Disease Questionnaire (CLDQ)
           in Tamil Language
    • Authors: Amit Goel; Karunanithi Arivazhagan, Avani Sasi, Vanathy Shanmugam, Seleena Koshi, Biju Pottakkat, C.P. Lakshmi, Ashish Awasthi
      Abstract: Background and Aim: Chronic Liver Disease Questionnaire (CLDQ), a self-administered quality-of-life (QOL) instrument for chronic liver disease (CLD) patients, was originally developed in English language. We aimed to translate and validate CLDQ in Tamil language (CLDQ-T).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.089
      Issue No: Vol. 7 (2017)
       
  • Relations Between Carotid Artery Wall Thickness and Liver Fibrosis in
           Subjects With NAFLD
    • Authors: Varun Mehta; Sahil Nohria, Bishav Mohan, Ajit Sood, Ramit Mahajan
      Abstract: Background and Aim: Studies have shown that the existence of fatty liver in diabetics is associated with an increase in cardiovascular morbidity and mortality specially caused by the liver. Liver biopsy is the gold standard of liver fibrosis evaluation, but it is a painful and invasive procedure. Carotid intima-media thickness (IMT) is one of the subclinical markers of atherosclerosis. Liver stiffness (LS) measurement using transient elastography (TE) has emerged as a promising noninvasive tool for assessing the degree of liver fibrosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.088
      Issue No: Vol. 7 (2017)
       
  • To Study Analysis of NAFLD Fibrosis Score Among Type 2 Diabetic Patients
           in Tertiarycare Hospital
    • Authors: Ramamoorthy G. Krishnan; A.R. Venkateswaran
      Abstract: Background and Aim: NAFLD is the commonest liver problem among 10–45% of population around the world. 72% of NAFLD patients has Type 2 DM. 10–75% of Type 2 DM patient has NAFLD. Asians has low prevalence. In India 10–24% of diabetics has NAFLD. It has spectrum with steatosis, steatohepatitis and advanced fibrosis. NAFLD fibrosis score, BARD, APRI, FIB-4 more widely used noninvasive tool to predict fibrosis. The study aimed to apply NAFLD fibrosis Score in separating NAFLD patients with or without fibrosis by using clinical and biochemical variables.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.087
      Issue No: Vol. 7 (2017)
       
  • Relative Adrenal Insufficiency in Alcoholic Hepatitis
    • Authors: Manoj Kumar; Gaurav K. Gupta, Shivadatta Padhi, Sandeep Nijhawan
      Abstract: Background and Aim: Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with high morbidity and mortality. The pathogenesis of alcoholic hepatitis is complex and involve oxidative stress, gut dysbiosis, and dysregulation of the innate and adaptive immune system similar to sepsis. It has been reported that adrenal insufficiency is common in sepsis. Further treatment with steroids decreases mortality in such patients. We hypothesize that adrenal insufficiency is associated with severe alcoholic hepatitis and affects prognosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.086
      Issue No: Vol. 7 (2017)
       
  • Prevalence and Clinico-Epidemiology of Nonalcoholic Fatty Liver Disease
           (NAFLD) in Patients With Metabolic Syndrome
    • Authors: Ajay Duseja; Abdul Khaliq, C.C. Choubal, Dipesh Sonawane, Dyotona S. Roy, Harshal Gadhikar, Manisha Bangar, Mukesh Agarwal, Rashmi Hedge, Ramesh R. Rai, Rahul Kothari, Samir Shah, Sanjeev Saigal
      Abstract: Background and Aim: Limited information is available on the prevalence and clinico-epidemiology of NAFLD in Indian patients with metabolic syndrome (MetS). The present study assessed the prevalence, clinical and epidemiological factors of NAFLD in patients with MetS.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.085
      Issue No: Vol. 7 (2017)
       
  • Cytokeratin-18 (CK-18) Is A Useful Biomarker in Differentiating Between
           NASH and No-NASH Amongst Patients With Nonalcoholic Fatty Liver Disease
           (NAFLD)
    • Authors: Manu Mehta; Ajay Duseja, Suvradeep Mitra, Ashim Das, Sunil Taneja, R.K. Dhiman, Y.K. Chawla
      Abstract: Background and Aim: Differentiation between nonalcoholic steatohepatitis (NASH) and no NASH is important for prognosis and treatment in patient with non-alcoholic fatty liver disease (NAFLD). There is paucity of data on the use of various biomarkers in differentiating NASH and no-NASH. In the present study three serum biomarkers cytokeratin-18 (CK-18), C-reactive protein (CRP), interlukin-6 (IL-6) were used to differentiate between NASH and no-NASH amongst patients with NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.084
      Issue No: Vol. 7 (2017)
       
  • Pharmacological and Non-Pharmacological Treatment Improves Quality of Life
           in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)
    • Authors: Mukesh K. Ranjan; Ajay Duseja, Sandeep Grover, Sunil Taneja, R.K. Dhiman, Y.K. Chawla
      Abstract: Background and Aim: Quality of life (QOL) is affected in patients with nonalcoholic fatty liver disease (NAFLD). There is no data on improvement of QOL with pharmacological treatment in these patients. Present study assessed the QOL in patients with NAFLD before and after pharmacological and non-pharmacological treatment.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.083
      Issue No: Vol. 7 (2017)
       
  • Protective Mechanisms Induced by Diallyl Sulfide in Ethanol-Mediated
           Injury in Rat Adipose Tissue and Human Primary Adipocytes
    • Authors: Aleem A. Khan; Sandeep K. Vishwakarma, Venkata H. Kema, Aviansh Bardia, L. Chandrakala, Palash Mandal, Md.A. Habeeb
      Abstract: Background and Aim: Alcohol consumption is the fourth leading cause of death and disability worldwide. Several cellular pathways contribute to alcohol mediated tissue injury. Adipose tissue apart from being functioning as an endocrine organ secretes several hormones and cytokines known as adipokines that are known to play a significant role in alcohol induced tissue damage. This study was designed to test the efficacy of diallyl sulfide (DAS) in regulating the alcohol induced outcomes on adipose tissue.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.082
      Issue No: Vol. 7 (2017)
       
  • Comparison of MELD and mDF Scoring Systems in Predicting 28 Day Mortality
           in Patients With Alcoholic Hepatitis
    • Authors: Sreedevi Sunkara; M. Umadevi
      Abstract: Background and Aim: The Model for End-stage Liver Disease (MELD) and Maddrey discriminant function (mDF) scoring systems have been used to predict the survival in patients with alcoholic hepatitis. The aim of present study is to compare MELD score, mDF score in predicting 28 day mortality, to study the clinical profile and to assess prognostic factors for patients with alcoholic hepatitis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.081
      Issue No: Vol. 7 (2017)
       
  • Burden of Obesity and Nonalcoholic Fatty Liver Disease in Helicobacter
           Infected Pakistani Population
    • Authors: Basit Siddiqui
      Abstract: Background and Aim: Obesity has recently been reported to have association with many disorders, including gastroesophageal reflux, erosions, carcinoma and Helicobacter pylori infection with its complex interplay with gut mirobiota and the most fearsome complication of obesity in the form of non-alcoholic steatohepatitis (NASH) and cirrhosis of liver. Although some studies report a negative association between obesity and H. pylori, their diagnostic modalities raised many questions. This study was done to determine the burden of obesity and nonalcholoic fatty liver disease (NAFLD) among patients diagnosed with H.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.080
      Issue No: Vol. 7 (2017)
       
  • IL-15 Dependent Lymphocyte Subsets Contribute to Fatty Liver Disease
    • Authors: Yuneivy C. Donates; Marian Mayhue, Subburaj Ilangumaran, Sheela Ramanathan
      Abstract: Background and Aim: Interleukin-15 (IL-15) that was initially characterized as a cytokine that is required for the maintenance of memory CD8+ T cells has a multi-faceted role in hematopoietic and non-hematopoietic system. IL-15 is a member of the gamma chain family of cytokines (gc—CD132). The IL-15 receptor (IL-15R) complex consists of 3 subunits: the ligand-binding IL-15Ra chain (CD215), the b chain (CD122; also used by IL-2), and the common g chain. The biological activities of IL-15 are mostly mediated by the IL-15:IL-15Ra complex, produced by the same cell and ‘trans-presented’ to responder cells expressing the IL-15Rbgc.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.079
      Issue No: Vol. 7 (2017)
       
  • Familial Clustering of Nonalcoholic Fatty Liver Disease Among the Family
           Members of Nonalcoholic Steatohepatitis Cirrhotic Patients
    • Authors: Saiful Islam; Shahinul Alam
      Abstract: Background and Aim: NAFLD is a multifactorial disorder. A combination of environmental, genetic and metabolic factors play role in the progression to advanced disease. Family members of NASH cirrhotic patients share some common factors and also probability of genetic predisposition, so chance of familial clustering of NAFLD is more among the family members. This study is aimed to explore the familial clustering of NAFLD among the family members of NASH cirrhotic patients and the association of insulin resistance, metabolic syndrome and genetic polymorphism with the familial clustering.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.078
      Issue No: Vol. 7 (2017)
       
  • Fibroscan to Detect Significant Fibrosis in NAFLD
    • Authors: Prijith A. Thomas
      Abstract: Background and Aim: Nonalcoholic fatty liver disease (NAFLD) constitutes a spectrum from steatosis to steatohepatitis and cirrhosis. Differentiating patients with significant fibrosis is important to prognosticate and follow up them. Fibroscan has high sensitivity in picking up patients with significant fibrosis. So we conducted this study on NAFLD patients who presented to our department with USG diagnosis of fatty liver to detect those with significant fibrosis and to compare with NAFLD and FIB-4 scores.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.077
      Issue No: Vol. 7 (2017)
       
  • Prevalence of Thyroid Disorders in Alcoholic Hepatitis Patients
    • Authors: Raju Kumar; Vinod K. Dixit, Sunit K. Shukla, Shivam Sachan, Sanjay K. Agarwal
      Abstract: Background and Aim: Thyroid hormone is maintains the metabolism of bilirubin by playing a role in the enzymatic activity of glucuronyl transferase and by regulating the level of ligandin. The liver has an important role in thyroid hormone metabolism it produces protein that bind thyroid hormone such as thyroxin binding globulin (TBG), prealbumin and albumin, it is also the major site of thyroid hormone peripheral metabolism and is involved in its conjugation of biliary excretion, oxidative deamination and extra thyroidal deiodination of thyroxin (T4) to triiodothyronine (T3).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.076
      Issue No: Vol. 7 (2017)
       
  • Slow Low-Dose Continuous Albumin, Furosemide±Terlipressin SIFA(±T) With
           N-acetycystine (NAC) Infusion in Severe Alcoholic Hepatitis
           (SAH)-Acute-On-Chronic Liver Failure (ACLF) With Organ Failure(S) Safely
           Mobilizes Ascites and Improves 28-Day Survival
    • Authors: Gaurav Pande; Abhimanyu Nehra, Kamlesh Kumar, Samir Mohindra, Uday C. Ghoshal, Abhai Verma, Alok Kumar, Manjunath Hatti, Vivek A. Saraswat
      Abstract: Background and Aim: Patients with severe SAH-ACLF with organ failure (OF) have high mortality and difficult to control ascites. Renal failure and oliguria are most common type of extra hepatic organ failure. This study aim to study the safety and efficacy of top-down therapy along with NAC in a response-guided manner in patients with SAH-ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.075
      Issue No: Vol. 7 (2017)
       
  • Predictors of Mortality in Treated Severe Alcoholic Hepatitis at Six
           Months
    • Authors: J.K. Antony; M.J. Chooracken, P.G. Mathew, J.V. Francis, A.P. Chettupuzha, R.J. Mukkada, A. Koshy
      Abstract: Background and Aim: Severe alcoholic hepatitis (SAH) is associated with significant mortality. We wish to analyze mortality at day 180, which is considered the window period for liver transplant in alcoholics with cirrhosis. The study was done to identify factors, which predict mortality in Severe alcoholic hepatitis receiving medical treatment.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.074
      Issue No: Vol. 7 (2017)
       
  • Study of Cardiovascular Profile of NAFLD Patients
    • Authors: Shivam Sachan; V.K. Dixit, S.K. Shukla, S.K. Singh, Gaurav Garg
      Abstract: Background and Aim: The NAFLD is one of the most common causes of chronic liver disease worldwide. It is histologically characterized by the presence of macrovesicular steatosis but occurs in the absence of excessive alcohol consumption. Its histological spectrum includes simple steatosis and steatohepatitis (NASH). As patients with NAFLD are enriched with risk factors known to cause and exacerbate atherosclerosis, it has been suspected that individuals with NAFLD are at heightened risk for cardiovascular disease.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.073
      Issue No: Vol. 7 (2017)
       
  • Vitamin D Status in Non-Alcoholic Fatty Liver Patients in North Indian
           Population
    • Authors: Sanjay K. Agrwal; Vinod K. Dixit, Sumit K. Shukla, Debesh Yadav, Shivam Sachan, Raju Kumar
      Abstract: Background and Aim: Vitamin D deficiency is a highly prevalent condition, present in approximately 50% of general population. A growing body of evidence suggests that low vitamin D level may adversely affect liver function. This study was designed to evaluate the association between vitamin D level measured as serum 25-hydroxy vitamin D [25(OH)D], and non-alcoholic fatty liver patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.072
      Issue No: Vol. 7 (2017)
       
  • Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) Gene
           Polymorphism Has a Significantly Stronger Association in Diabetics With
           Advanced Liver Disease as Compared to Diabetics Without Liver Disease
    • Authors: Sachet V. Chandak; Deepak N. Amarapurkar, Nirali Shah, Sunil Parekh
      Abstract: Background and Aim: Recent evidence suggests a key role of the host genetics in modulating the natural history of any chronic liver disease. A single nucleotide polymorphism (SNP) in patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) has been implicated in the variation of NAFLD and in the severity of histologically confirmed NAFLD in both adults and children. PNPLA3 Polymorphisms has been studied mainly in Caucasians, Asians and Africans. However, there are no studies till date reporting a positive association of PNPLA3 (rs738409) polymorphism with liver fibrosis in exclusively Indian diabetic population.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.071
      Issue No: Vol. 7 (2017)
       
  • Prevalence and Risk Factors for Dyslipidemia in Patients With
           Non-Alcoholic Fatty Liver Disease (NAFLD)
    • Authors: Shivaram P. Singh; Manorama Swain, Preetam Nath, Prasanta K. Parida, Jimmy Narayan, Pradeep K. Padhi, Girish K. Pati, Ayaskanta Singh, Bijay Misra, Debasis Misra, Sanjib K. Kar, Manas K. Panigrahi, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Kaumudee Pattnaik, Pallavi Bhuyan
      Abstract: Background and Aim: Dyslipidemia has been closely associated with NAFLD and is recognized as a risk factor for NAFLD. We conducted this study to evaluate the prevalence of dyslipidemia and its risk factors in a large cohort of NAFLD patients from coastal eastern India.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.070
      Issue No: Vol. 7 (2017)
       
  • Metabolic Aberrations in Type 2 Diabetics With Different Grades of
           Ultrasonographic Non-Alcoholic Fatty Liver Disease
    • Authors: Kuhu Roy; Uma Iyer, Rumin Shah, Tushar Vaishnav
      Abstract: Background and Aim: Non-alcoholic fatty liver disease (NAFLD) in type 2 diabetics is the stepping stone to unfavourable health outcomes. The metabolic aberrations that occur in each grade of ultrasonographic NAFLD have been meagrely explored. Therefore, we aimed to assess the metabolic aberrations in different grades of ultrasonographic NAFLD in type 2 diabetics.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.069
      Issue No: Vol. 7 (2017)
       
  • Severe Alcoholic Hepatitis: Prognosis and Complications
    • Authors: Gaurav Garg; Vinod K. Dixit, Sunit K. Shukla, Sudhir K. Singh, Shivam Sachan
      Abstract: Background and Aim: Recently, the incidence of alcoholic liver disease (ALD) has been increasing with an increase in alcoholic beverage consumption.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.068
      Issue No: Vol. 7 (2017)
       
  • Association of Single Nucleotide Polymorphism At PNPLA3 With Fatty Liver,
           Steatohepatitis and Cirrhosis of Liver
    • Authors: Shahinul Alam; Shaiful Islam, Saiful Islam, Golam Mustafa, Nooruddin Ahmad
      Abstract: Background and Aim: Single nucleotide polymorphism (SNP) in patatin like phospholipase domain containing 3 (PNPLA3) is associated with NAFLD, but the relation with severity and cirrhosis is yet to be studied. The aim of this study was to determine the association of SNP in PNPLA3 at I148 with histological severity, fibrosis and cirrhosis of nonalcoholic fatty liver disease (NAFLD).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.067
      Issue No: Vol. 7 (2017)
       
  • Chemical Chaperone 4-Phenyl Butyric Acid (4-PBA) Reduces Hepatocellular
           Lipid Accumulation and Lipotoxicity Through Induction of Autophagy
    • Authors: Nissar U. Ashraf; Love Sharma, Mudasir A. Malik, Nazir A. Lone, Praduman K. Sharma, Tasduq Abdullah
      Abstract: Background and Aim: Impaired autophagic flux has been observed in hepatocytes of NAFLD and NASH patients. Autophagy modulators like 4-PBA may have a therapeutic role in treating NAFLD or related lipo-toxicity. We aimed to investigate autophagy in lipid-stimulated hepatocytes and tested whether 4-Phenyl butyric acid (4-PBA) has beneficial role in preventing hepatic lipid accumulation and lipo-toxicity.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.066
      Issue No: Vol. 7 (2017)
       
  • Rash With Leucocytoclastic Vasculitis a Novel Hepatocutaneous Marker in
           HBV—A Case Report
    • Authors: Rahul D. Arora; Rakhi Maiwall, Sumeet Kainth
      Abstract: Background and Aim: Extrahepatic manifestations of Hepatitis B virus infection can be classified into cutaneous (bullous pemphigoid, lichen planus, gianotti crossti syndrome) and extracutaneous syndromes (glomerulonephritis, polyarteritis nodosa, cryoglobulinemia and gullian barre syndrome)
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.065
      Issue No: Vol. 7 (2017)
       
  • Successful Treatment of Chronic Hepatitis C Infection With Directly Acting
           Antivirals in Renal Transplant Recipients
    • Authors: Sunil Taneja; Ajay Duseja, Arka De, Vivek Kumar, Raja Ramachandran, Ashish Sharma, R.K. Dhiman, K.L. Gupta, Y.K. Chawla
      Abstract: Background and Aim: Data regarding the treatment of chronic hepatitis C (CHC) in renal transplant recipients is lacking in the Asia-Pacific region. Aim of the present study was to assess the safety and efficacy of directly acting antivirals (DAAs) in the treatment of chronic hepatitis C (CHC) infection in renal transplant recipients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.064
      Issue No: Vol. 7 (2017)
       
  • Role of Steroids in Cholestatitc Viral Hepatitis A and E
    • Authors: P. Deepak Ganga; Vishnuvardhan Reddy, Tarun S. Joseph, G. Balaji, Syed Shafiq, Mallikarjun, Harshad C. Devarbhavi
      Abstract: Background and Aim: Acute hepatitis A & E are generally self-limiting illnesses. However severe cholestasis with debilitating symptoms is seen in minority of patients, which cause immense psychological burden apart from requiring, prolonged hospitalizations & increased medical costs. We report 4 such patients with prolonged cholestatic symptoms who were initiated on steroids (40mg prednisolone) and tapered weekly depending on the response.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.063
      Issue No: Vol. 7 (2017)
       
  • Hepatic Involvement Have Significant Impact on Clinical Outcome in
           Patients of Dengue Fever: A North Indian Observational Study
    • Authors: Sanjay Mehrotra; Ajay Kumar, Shivabrata D. Mohapatra, Ravi Misra, Virendra Atam
      Abstract: Background and Aim: Dengue fever, also known as break bone fever, does the dengue virus cause a mosquito-borne tropical disease. Symptoms include fever, headache, muscleache, joint pains, and rashes. It is transmitted mainly by Aedes aegypti mosquito and also by Aedes albopictus. The WHO classified dengue into, dengue fever (DF), dengue hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS). The study was done to evaluate the hepatic involvement in Dengue fever and its correlation with its outcome.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.062
      Issue No: Vol. 7 (2017)
       
  • Safety and Efficacy of Sofosbuvir Based Regimen on Patients With End Stage
           Renal Disease—A Single Centre Experience
    • Authors: Chinmay Bera; Pratik Das, Sandip Pal
      Abstract: Background and Aim: Prevalence of chronic hepatitis C (CHC) is significantly higher in patients with end stage renal disease, particularly those receiving hemodialysis. There are very few studies available to prove the safety and efficacy of sofosbuvir based regimen for treatment of CHC in patients with ESRD. This is a single center experience of using sofosbuvir-based therapy in patients with ESRD.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.061
      Issue No: Vol. 7 (2017)
       
  • Role of Novel Micro-RNA Identified by Small RNA Sequencing in the Disease
           Progression of Hepatitis C Infection
    • Authors: Suchandrima Ghosh; Joyeeta Chakraborty, Amit Ghosh, Priyanka Kumari, Susree Roy, Shaleen Agarwal, Subash Gupta, Raghunath Chatterjee, Gopal K. Dhali, Abhijit Chowdhury, Soma Banerjee
      Abstract: Background and Aim: Hepatitis C virus (HCV) infection is one of the important etiologies of hepatocellular carcinoma (HCC), and has a very complex mechanism of disease progression. Though extensive research is going on to unveil the underlying HCV pathogenesis and its disease progression; but it remains a complicated riddle to solve. However, advancement of high throughput RNA sequencing has made the investigation of cellular processes and their regulations easier. MicroRNAs are the master regulators of myriads of cellular pathways involved in disease pathogenesis and progression.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.060
      Issue No: Vol. 7 (2017)
       
  • Epidemiology, Clinical Features, Serological Markers, and Outcome of
           Chronic Hepatitis B in Pregnancy
    • Authors: Pazhanivel Mohan; Kuppusamy S. Selvan, Anuran Mukherjee, Vasanthakumari Udayakumar, Ramadevi Mohan, Abdoul Hamide
      Abstract: Background and Aim: Chronic hepatitis B and its effects on pregnancy are variable. Some studies have shown a higher risk for preterm delivery, antepartum haemorrhage and gestational diabetes. The presence of hepatitis B envelope antigen (HBeAg) and high maternal DNA increases the risk of mother to child transmission (MCT). The objective of our study was to detect the frequency of clinical flares, liver function abnormalities, pattern of serological markers, maternal and foetal outcome in pregnant women with chronic hepatitis B.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.059
      Issue No: Vol. 7 (2017)
       
  • Pan Genotypic Response to Combination Treatment With Sofosbuvir and
           Daclatasvir in Chronic Hepatitis C Patients
    • Authors: Anup S. Nair; Thazhayil M. Ramachandran
      Abstract: Background and Aim: Hepatitis C is a major cause of liver related morbidity and mortality. Prevalence of HCV infection in India has been variously estimated as 0.9–1.9%. With the advent of DAAs, the treatment has been revolutionized with more than 95% cure rate as observed in caucasian population, while only scarce data on the same are available in the indian population. Our study aimed to assess the pan genotypic treatment response (SVR 12) to Sofosbuvir and Daclatasvir combination.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.058
      Issue No: Vol. 7 (2017)
       
  • Pan Genotypic HCV Therapy by Micro RNA Mediated Silencing of the Host
           Factors
    • Authors: Suchandrima Ghosh; Sayantani Bhowmik, Simanti Datta, Gopal K. Dhali, Abhijit Chowdhury, Soma Banerjee
      Abstract: Background and Aim: Hepatitis C virus (HCV) infection leads to end stage liver diseases like hepatocellular carcinoma, which causes devastating problem for the patient and a huge financial burden on the society in developing countries with limited resources. But, the treatment of HCV involves drugs targeting the viral proteins, which have got limitations like genotypic barriers, drug resistance and possible recurrence after liver transplantation. Targeting host factors, aiding HCV life cycle can rule out the above complications.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.057
      Issue No: Vol. 7 (2017)
       
  • FIB-4 Index as a Non-Invasive Diagnostic Tool for Histological Changes in
           Liver in Patient With Chronic Hepatitis B
    • Authors: Most R. Begum; Mamun A. Mahtab, Noor E. Alam
      Abstract: Background and Aim: Liver histology is crucial in determining prognosis and need for treatment in CHB patient for which liver biopsy is the gold standard. But this procedure is invasive, costly and carries a definite risk of complications. To optimize management and predict long term clinical courses in patient with CHB, non-invasive test to determine the degree of hepatic fibrosis is a demand of present situation. General objective was to evaluate FIB-4 score as non-invasive marker of liver histology on patients with chronic hepatitis B.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.056
      Issue No: Vol. 7 (2017)
       
  • Epidemiological Profile and Clinical Characteristics of Patients With
           Hepatitis B Infection
    • Authors: Jayshri A. Shah
      Abstract: Background and Aim: To describe the demographic and clinical characteristics of patients with hepatitis B. To assess correlation of non invasive methods for assessment of hepatic steatosis (HS) and fibrosis in patients with chronic hepatitis B (CHB).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.055
      Issue No: Vol. 7 (2017)
       
  • Sofosbuvir Based Regimen in Management of Hepatitis C for Patients With
           End Stage Renal Disease on Hemodialysis: A Single Center Experience From
           India
    • Authors: Ankur Gupta; Puneet Arora, Priyanka Jain
      Abstract: Background and Aim: Hepatitis C infection is known to increase the morbidity in patients with end stage renal disease (ESRD). Interferon based treatment is poorly tolerated and has limited cure rates in these patients. In limited available data, Sofosbuvir based regimens have been shown to have favorable outcomes in these patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.054
      Issue No: Vol. 7 (2017)
       
  • Correlation Between HBeAg Status, HBV DNA, ALT, AST, GGT and Liver
           Histological Activity in Patients With Chronic Hepatitis B Virus Infection
           
    • Authors: Kazi Z. Hossain; Nooruddin Ahmad, Sheikh M. Noor-e-Alam, Md J. Sarker, Foyez A. Khondoker, Mamun A. Mahtab
      Abstract: Background and Aim: Chronic hepatitis B virus (HBV) infection remains a serious public health problem affecting more than 400 million people worldwide. In this study, we aimed to investigate whether there is any correlation between HBeAg status, HBV DNA, ALT, AST, GGT level and liver histological activity in patients with chronic hepatitis B virus infection.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.053
      Issue No: Vol. 7 (2017)
       
  • Impact of Directly Acting Antiviral Drugs During Treatment of
           Decompensated Cirrhosis With Chronic Hepatitis C
    • Authors: Hemanta K. Nayak; Vivek A. Saraswat, Samir Mohindra, Gaurav Pandey
      Abstract: Background and Aim: Management of hepatitis C virus (HCV) infection in patients with decompensated liver cirrhosis (LC) has evolved dramatically over the last two years due to the availability of all-oral antiviral regimens. Currently, all the approved direct-acting antivirals (DAA) in India [sofosbuvir (SOF), ledipasvir (LDV), daclatasvir (DCV) and ribavirin (RBV)] are safe and effective in decompensated cirrhosis. In this study we assessed the ETR (end-of-therapy) response and liver function improvement to DAA therapy in decompensated cirrhosis
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.052
      Issue No: Vol. 7 (2017)
       
  • Antiviral Therapy Only for Patients With Hepatitis B Post Liver
           Transplant—Single Center Experience
    • Authors: Nivedita Pandey; Sukrit Sethi, Subhash Gupta
      Abstract: Background and Aim: Liver Transplantation is an important treatment modality for patients with Hepatitis B related chronic liver disease. The risk of reinfection with Hepatitis B post-transplant is a grave concern. Current recommendations endorse use of both Hepatitis B immunoglobulin (HBIG) and antiviral drugs post-transplant. We report our center's experience with using only antiviral therapy post liver transplant.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.051
      Issue No: Vol. 7 (2017)
       
  • Renal Safety of Long Term Tenofovir Therapy in Hepatitis B: Longitudinal
           Observation Study From a Tertiary Care Centre in South India
    • Authors: N. Sandeep; Ponni Krishnan, Krishnadas Devadas
      Abstract: Background and Aim: Tenofovir associated renal dysfunction has been described in several case reports and studies in HIV infected patients but studies in Hepatitis B patients receiving Tenofovir are less. Aim of this study was to determine the decline in estimated glomerular filtration rate (eGFR) by Cockroft-Gault formula in patients taking Tenofovir for CHB/HBV related compensated CLD/Acute HepatitisB.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.050
      Issue No: Vol. 7 (2017)
       
  • Cost-Effectiveness of Hepatitis C Treatment using Generic Direct-Acting
           Antivirals Available in India
    • Authors: Rakesh Aggarwal; Qiushi Chen, Amit Goel, Nicole Seguy, Razia Pendse, Turgay Ayer, Jagpreet Chhatwal
      Abstract: The author is a staff member of the World Health Organization. The author alone is responsible for the views expressed in this publication and they do not necessarily represent the decisions or policies of the World Health Organization.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.049
      Issue No: Vol. 7 (2017)
       
  • Outcome of Acute Viral Hepatitis in Diabetic and Non Diabetic Patients in
           Bangladesh-Report From a Tertiary Centre
    • Authors: Mohd H.O. Rashid
      Abstract: Background & Aim: AVH is a self-limiting pathological entity, DM is endowed with long-term influence on different pathological conditions. The study presented here was designed to assess if DM has any role on clinical course of AVH.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.048
      Issue No: Vol. 7 (2017)
       
  • Results of Sofosbuvir (SOF) Based Combination Therapy for Chronic
           Hepatitis C Infection Including Compensated Cirrhosis: A Real Life
           Clinical Practice Experience
    • Authors: Kamlesh Kumar; Gaurav Pandey, Hemant K. Nayak, Samir Mohindra, Vivek A. Saraswat
      Abstract: Background and Aim: We report our experience with DAA's for CHC infection from a tertiary care center of northern India where genotype-3 (GT-3) is predominant and a very high proportion of patients have liver cirrhosis (LC), which constitute a difficult-to-treat population. The study was done to evaluate the efficacy and safety of different Sofosbuvir (SOF) based regimens in patients with CHC infection.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.047
      Issue No: Vol. 7 (2017)
       
  • A Study on Prevalence of Hepatitis C Among Adult Population in South
           Kashmir
    • Authors: Nisar A. Shah; Showkat A. Kadla, Jaspreet Singh, Bilal A. Khan, Asif I. Shah, Shabir A. Sheikh, Majid K. Rather, Rupakshi Pathania
      Abstract: Background and Aim: Hepatitis C was first detected in 1989 using molecular biology techniques after extensive testing of serum from experimentally infected animals. It was later characterized to be an RNA virus that belongs to the Flaviviridae family and genus hepacivirus. According to recent estimates, more than 185 million people around the world are infected with HCV, of whom 350000 die each year. Not many community-based studies are available from our country and none from the state of Jammu and Kashmir and thus present study was conducted to estimate the prevalence of Hepatitis-C among adult population in South Kashmir.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.046
      Issue No: Vol. 7 (2017)
       
  • Diagnostic Accuracy of FIB-4, APRI and AST/ALT Ratio for Prediction of
           Fibrosis in Chronic Hepatitis B ANDC Patients
    • Authors: Showkat A. Kadla; Nisar A. Shah, Irfan A. Mir, Bilal A. Khan, Asif I. Shah, Shabir A. Sheikh, Khalid Javed, Mohamad A. Dar, Jaspreet Singh
      Abstract: Background and Aim: Accurate assessment of liver fibrosis is essential for successful individualized disease management for people with chronic hepatitis B and C. Although liver biopsy remains gold standard for diagnosis of liver fibrosis, it has some limitations. To overcome these limitations multiple non-invasive modalities have been introduced. Main aim of our study was to validate the various fibrosis-scoring systems with liver biopsy and give recommendations to replace it with these scoring systems if feasible in hepatitis B and C.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.045
      Issue No: Vol. 7 (2017)
       
  • Long Term Safety and Efficacy of Tenofovir in Nucleos(t)ide (NA)
           Analog—Experienced Chronic Hepatitis B Patients
    • Authors: Pinakin S. Patel; Deepak N. Amarapurkar
      Abstract: Background and Aim: Tenofovir disoproxil fumarate (TDF) has demonstrated high antiviral efficacy in treatment-naïve patients with chronic HBV infection but experience in nucleoside/nucleotide analogue (NA)-experienced patients is limited. This study assessed the efficacy and safety of TDF up to 10 years of NA-experienced CHB patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.044
      Issue No: Vol. 7 (2017)
       
  • There is no Need of Investigating for Genotype if we use Sofosbuvir and
           Daclatasvir for Chronic Hepatitis C Infection
    • Authors: Amar Deep; Ajay Kumar, Suchit Swaroop
      Abstract: Background and Aim: The goal of chronic hepatitis C treatment is to remove the virus to avoid progression of HCV-related disease. Sustained virologic response (SVR) is the most widely used efficacy endpoint in clinical studies of hepatitis C, and represents the eradication of HCV from the body. In the Compassionate use programme in Europe, Sofosbuvir (SOF) and Daclatasvir (DCV) was used in all genotypes and achieved SVR-12. So we tried to compare patients who could not afford for investigating of HCV-Genotype price, to those in whom genotype was done.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.043
      Issue No: Vol. 7 (2017)
       
  • Can Fibroscan Replace Liver Biopsy in Assessing Treatment Response in
           Chronic Hepatitis B' A Comparative Analysis of Staging of Fibrosis by
           the Two Methods in Rural Tertiary Care Centre
    • Authors: A. Shafique; R. Ramasubramanian, Y. Jaipaul
      Abstract: Background and Aim: The treatment of chronic hepatitis B is always challenging. Treatment response varies among individual depending on viral load, drug resistance etc. Hence staging system is necessary during course of therapy.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.042
      Issue No: Vol. 7 (2017)
       
  • Reactive Oxygen Species Produced by HBV Help in Replication and Autophagy
           in Host Cells
    • Authors: Amit K. Mishra; Kishor Pant, Saman M. Pradhan, Senthil K. Venugopal
      Abstract: Background and Aim: Hepatitis B Virus (HBV) is responsible for liver cirrhosis, fibrosis and hepatocellular carcinoma (HCC) worldwide. HBV modulates many cellular and molecular factors in host cells for its replication and survival including, ROS is considered to inhibit the cellular antioxidants and SIRT-1 expression. However, the exact molecular mechanisms involved in the ROS-induced autophagy and HBV replication has been not known.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.041
      Issue No: Vol. 7 (2017)
       
  • A Prospective Study to Evaluate the Outcome of Hepatitis B Patients
           Presenting With Jaundice
    • Authors: Pathik Parikh; Aabha Nagral, Nishtha Nagral
      Abstract: Background and Aim: Differentiating acute hepatitis B from reactivation of chronic hepatitis B (CHB) is essential as one group requires treatment while other just observation for spontaneous clearance.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.040
      Issue No: Vol. 7 (2017)
       
  • Experience of Treating Hepatitis C Genotype 3 Virus Chronic Infection
           Using Direct Acting Antiviral Drugs
    • Authors: Amit Goel; H.J. Vijay Kumar, Rajat Bhargava, Praveer Rai, Rakesh Aggarwal
      Abstract: Background: Directly-acting anti-viral drugs (DAAs) are currently the favored treatment for HCV infection. However, the experience with these drugs in the treatment of genotype-3 (gt3) HCV, particularly prevalent in India, is limited. We therefore reviewed our experience with these drugs in treating patients with chronic gt3 HCV infection, including those with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.039
      Issue No: Vol. 7 (2017)
       
  • Modulation of Host Cellular Pathways by HBV-Induced ROS in Modulating
           Autophagy and Inflammation in Hepatic Cells
    • Authors: Senthil K. Venugopal; Kishor Pant, Amit Misra, Saman Pradhan
      Abstract: Background and Aim: Hepatitis B virus, a ds-DNA Virus, is one of the major risk for the development of chronic liver disease. HBV modulates several cellular pathways for its own survival and replication in the host cells. Reactive oxygen species (ROS) that are produced in the host cells during HBV infection, was considered to inhibit the cellular antioxidants and SIRT-1 expression. However, the role for HBV-induced ROS in modulating autophagy, proliferation and viral replication is not known. Hence, we hypothesized that HBV might modulate host factors through ROS in hepatic cells.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.038
      Issue No: Vol. 7 (2017)
       
  • Inhibition of HBV Induced Autophagosome Formation in HEPG2 Cells by Humic
           Matter
    • Authors: Ajay K. Yadav; Kishor Pant, Senthil K. Venugopal
      Abstract: Background and Aim: Hepatitis B Virus (HBV) is among the leading cause of the hepatocellular carcinoma and liver cirrhosis. The HBV induces its survival and pathogenesis by the formation of the autophagosome formation by its virulent protein named HBx, which also responsible for tumorgenesis in hepatic cells. In our study, humic acid (HA) showed the anti-HBV properties via inhibiting the autophagosome formation and inducing the cell death.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.037
      Issue No: Vol. 7 (2017)
       
  • Butyrate Inhibits HBV Replication and HBV Induced Inflammation
    • Authors: Kishor Pant; Senthil K. Venugopal, Saman M. Pradhan, Amit K. Mishra
      Abstract: Background and Aim: Hepatitis B Virus is a ds-DNA Virus, responsible for hepatocellular carcinoma (HCC), liver cirrhosis, fibrosis and a large number of mortality worldwide. HBV modulates many cellular factors for its replication and survival in host cell. During HBV infection the inflammation is also reported to be elevated via deregulation of the many cellular proteins, responsible for the liver many liver diseases. The specifically targeting the HBV replication and HBV induced inflammation is not developed hitherto.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.036
      Issue No: Vol. 7 (2017)
       
  • Experience With Direct Acting Antivirals (DAA) Agents in Treatment of
           Chronic Hepatitis C Virus (HCV) Infection in Patients of Thalassemia Major
           
    • Authors: Aabha Nagral; Smita Sawant, Priya Malde, Pathik Parikh, Nishtha Nagral, Rashid Merchant
      Abstract: Background and Aim: Patients with Thalassemia major (TM) are transfusion dependent and therefore at a high risk of acquiring Hepatitis C (HCV) infection. There is sparse data of treating HCV in TM with direct acting antivirals.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.035
      Issue No: Vol. 7 (2017)
       
  • Direct Acting Antiviral Treatment Response in Chronic Hepatitis C
           Infection: Data From Tertiary Care Center in South India
    • Authors: Siddharth R. Dharamsi; Mukundan Swaminathan, L. Venkatakrishnan, J. Krishnaveni, Naveen Mohandas, Vijayanand Vegiraju, Vishnu Abishek, Aditya Kulkarni, Prudhvi Krishna Ch, Kvksn Murthy
      Abstract: Background and Aim: To assess the prevalence of HCV genotypes in southern India and the response to treatment with directly acting antivirals (DAA).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.034
      Issue No: Vol. 7 (2017)
       
  • Pirfenidone Related Acute Liver Failure
    • Authors: Nipun Verma; Sunil Taneja, Radha K. Dhiman, Yogesh Chawla
      Abstract: Background: Drug-induced liver injury (DILI) is the second most common cause of liver failure and carries a high mortality. Pirfenidone is an antifibrotic drug, commonly used in patients with idiopathic pulmonary fibrosis (IPF). Despite the reports on reduced liver fibrosis, it is associated with hepatotoxicity (transaminitis). Here we describe a previously unreported case of ALF resulting from pirfenidone.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.033
      Issue No: Vol. 7 (2017)
       
  • Neutrophil Dysfunction in Acute on Chronic Liver Failure
    • Authors: Kunaal Makkar; Shallu Tomer, Sahaj Rathi, Sunil K. Arora, Sunil Taneja, Ajay Duseja, Yogesh K. Chawla, Radha K. Dhiman
      Abstract: Background and Aim: Innate immune dysfunction in patients of acute on chronic liver failure (ACLF) is known to play important role in dysregulated immune response. We looked for neutrophil dysfunction in ACLF patients and its role in 28- and 90-day mortality.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.032
      Issue No: Vol. 7 (2017)
       
  • Dynamic Assessment is Superior to Baseline Assessment of Prognostic Scores
           in Risk Stratification of Acute on Chronic Liver Failure
    • Authors: Sahaj Rathi; Sunil Taneja, Ajay Duseja, Yogesh K. Chawla, Radha K. Dhiman
      Abstract: Background and Aim: Acute on Chronic Liver Failure (ACLF) is a dynamic syndrome leading to high risk of mortality among patients with chronic liver disease. While definitions of acute event and underlying chronic liver disease are widely debated, all prognostic scoring models are based on baseline variables. We evaluated a dynamic model of prognosis assessment and compared it with the static models for prediction of short-term mortality.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.031
      Issue No: Vol. 7 (2017)
       
  • Plasma Lactate Predicts Mortality in Children With Acute Liver Failure
           With Jaundice to Encephalopathy Interval Less Than 7 Days
    • Authors: Arti Pawaria; Seema Alam, Rajeev Khanna, Vikrant Sood
      Abstract: Background and Aim: There is limited data regarding factors predicting outcome or need for liver transplant children with pediatric acute liver failure (PALF) with jaundice to encephalopathy interval (JEI) less than seven days. We conducted this study to assess factors that can predict poor outcome in children with PALF with JEI of less than seven days.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.030
      Issue No: Vol. 7 (2017)
       
  • Significant Increase in Intestinal Permeability in Acute-On-Chronic Liver
           Failure (ACLF) is Reversed After Slow Albumin Furosemide Infusion With or
           Without Terlipressin
    • Authors: V.P. Krishna; Gaurav Pandey, Dinesh Kumar, Umesh Kumar, Samir Mohindra, Manjunath Hatti, Alok, Prabat N. Sharma, Vivek Saraswat
      Abstract: Background and Aim: Increased intestinal permeability (IP), increased bacterial translocation (BT), small intestinal bacterial overgrowth (SIBO) and gut dysbiosis are well known in liver cirrhosis (LC). In acute-on-chronic liver failure (ACLF), marked increase in IP and BT may occur due to a surge in portal hypertension. The study was done to compare IP in healthy controls, in patients with decompensated liver cirrhosis and in patients with ACLF before and after control of large ascites with SAFI±T therapy.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.029
      Issue No: Vol. 7 (2017)
       
  • A Sinister Cause of Extreme Hepatitis
    • Authors: Vishnu V. Reddy; Tarun S. Joseph, Deepak Ganga, Syed Shafiq, G. Balaji, P. Mallikarjun, Harshad C. Devarbhavi
      Abstract: Background and Aim: Acute liver injury/failure is a life threatening medical emergency which if promptly recognized and managed can be life saving. History of drugs and dietary supplements including herbals is of paramount importance in the management of acute liver injury as they are potentially avertible. Here we report one such case of acute liver injury.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.028
      Issue No: Vol. 7 (2017)
       
  • Clinical and Laboratory Determinants of Short-Term Transplant-Free
           Survival in Acute Liver Failure in India—A Prospective Study
    • Authors: Vignesh Chidambaram; Abdoul Hamide, Pazhanivel Mohan
      Abstract: Background and Aim: Acute Liver Failure (ALF) is a serious syndrome with high mortality, caused mainly by viral hepatitis and toxins in India. Though MELD score and KCH criteria are commonly used as indicators of prognosis in ALF, there is a need for determining their prognostic accuracy in this population. The study was done to identify the etiology and the factors associated with the outcome and to evaluate MELD score and KCH criteria, in ALF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.027
      Issue No: Vol. 7 (2017)
       
  • Arterial Ammonia Independently Predicts Outcome in Acute on Chronic Liver
           Failure
    • Authors: Shekhar S. Jadaun; Gyan Ranjan, Gyan Rout, Ujjwal Sonika, Mona Pathak, Saurabh Kedia, Deepak Gunjan, Baibaswata Nayak, Subrat K. Acharya, Shalimar
      Abstract: Background and Aim: Elevated ammonia correlates with outcome and complications in acute liver failure. However, role of arterial ammonia in predicting outcome of acute on chronic liver failure (ACLF) is unclear. We evaluated the association of arterial ammonia with complications and outcome in ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.026
      Issue No: Vol. 7 (2017)
       
  • Vitamin D3 and Thymosin β4 Level as a Biomarker of Prognosis in Acute
           on Chronic Liver Failure
    • Authors: Gireesh K. Dhaked; Suresh Kumar, Premashis Kar
      Abstract: Background and Aim: There are many prognostic markers are available to predict the outcome of patients with Acute-on-chronic liver failure (ACLF). Thymosin β4 could be beneficial for the treatment of chronic liver disease as it up regulates the expression of HGF and downregulates the expression of PDGF-β receptor in human hepatic stellate cells. Vitamin D is also linked to liver fibrosis and to liver cirrhosis. This study was conducted to find vitamin D3 and thymosin β4 level as a biomarker of prognosis in acute on chronic liver failure.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.025
      Issue No: Vol. 7 (2017)
       
  • Clinical Features, Incidence of Hepatic Encephalopathy and Bacteriological
           Profile of Adult Acute Liver Failure: A Single Centre Prospective Cohort
           Study
    • Authors: Chetan Kalal; Rakhi Maiwall, Shiv Sarin
      Abstract: Background and Aim: Acute liver failure (ALF) is associated with high morbidity and mortality. Intensive care and liver transplantation provide support and rescue, respectively. The study was done to determine the clinical characteristics and bacteriological profile of ALF patients.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.024
      Issue No: Vol. 7 (2017)
       
  • Comparative Study on the Response of Tenofovir Mono Therapy Versus
           Tenofovir Plus Telbivudine Dual Therapy in Patients With Hepatitis B Virus
           Related Acute on Chronic Liver Failure
    • Authors: Abul H. Manik; Sheikh M.N. Dew, Mamun A.M. Shwapnil, Salimur Rahman
      Abstract: Background and Aim: Severe acute spontaneous exacerbation of CHB leading to ACLF is extremely poor, with mortality ranging from 30% to 70%. Therefore, early and rapid reduction of HBV DNA is the essence of therapy in ACLF-B.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.023
      Issue No: Vol. 7 (2017)
       
  • Slow Infusion of Furosemide and Albumin With or Without Terlipressin in
           Acute on Chronic Liver Failure Patients With Organ Failure(s): Safety and
           Efficacy in Ascites Mobilization and Effect on 28 Day Survival
    • Authors: Gaurav Pandey; Alok Sharma, Abhimanyu Nehra, Kamlesh Kumar, Samir Mohindra, Uday C. Ghoshal, Abhai Verma, Vivek A. Saraswat
      Abstract: Background and Aim: Ascites mobilization in patients with Acute on chronic liver failure (ACLF) patients with organ failures is difficult. We aim to study the efficacy of slow infusion of furosemide, albumin and/or terlipressin SIFA (T) as per response guided protocol to achieve complete ascites mobilization.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.022
      Issue No: Vol. 7 (2017)
       
  • Slow Infusion of Furosemide and Albumin With or Without Terlipressin
           SIFA(T) Improves Deranged Systemic Hemodynamics and Survival in Patients
           With Severe Acute-On-Chronic Liver Failure (ACLF)
    • Authors: Prabhatnarain Sharma; V.P. Krishna, Alok Sharma, Manjunath Hatti, Gaurav Pandey, Vivek A. Saraswat
      Abstract: Background and Aim: ACLF is characterized by abrupt onset of severe liver dysfunction with extrahepatic organ failure(s) but with potential for reversal once the acute insult resolves. Although deranged systemic hemodynamics underpins extrahepatic organ failure, especially renal and circulatory failure, changes in systemic hemodynamics after recovery or after complete mobilization of ascites have not been reported. We studied systemic hemodynamics in ACLF before and after complete mobilization of ascites with slow infusion of furosemide and albumin with or without terlipressin [SIFA(T)] and its impact on determining the clinical outcomes.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.021
      Issue No: Vol. 7 (2017)
       
  • Acute Budd Chiari Syndrome in Patients With Acute Liver Failure: A
           Retrospective Study
    • Authors: Manzar H. Usmani; Vinod K. Dixit, Sunit K. Shukla, Gaurav Garg, Anurag Tiwari
      Abstract: Background and Aim: Budd-Chiari syndrome (BCS) is characterized by hepatic venous outflow obstruction. Pregnancy is a relatively common risk factor for BCS and a hypercoagulable state in the physiological preparation for delivery. However, BCS may also rapidly evolve to acute liver failure (ALF-BCS). The aim of this study was to study the profile of ALF and ALF-BCS and to evaluate the causative factors.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.020
      Issue No: Vol. 7 (2017)
       
  • Comparative Evaluation of Acute on Chronic Liver Failure Among Alcoholic
           and Nonalcoholic Sub-Population
    • Authors: Manish K. Bhaskar; Vinod K. Dixit, Sunit K. Shukla
      Abstract: Background and Aim: ACLF is characterized by acute hepatic insult manifesting as jaundice and coagulopathy, complicated within 4 weeks by ascites and/or encephalopathy in patients with previously diagnosed or undiagnosed chronic liver disease and is associated with a high 28-day mortality. we comparatively studied prevalence, mortality rate among alcoholic and nonalcoholic ACLF. We also evaluated epidemiological differences in alcoholic and nonalcoholic ACLF and tried to assess different prognostic factors.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.019
      Issue No: Vol. 7 (2017)
       
  • Comparative Evaluation of Hematological, Biochemical Parameters and
           Prognostic Scores in Survivor and Non-Survivor Groups of ACLF Patients
    • Authors: Manish K. Bhaskar; Vinod K. Dixit, Anurag Tiwari, Ajay Nandmer
      Abstract: Background and Aim: ACLF is characterized by acute hepatic insult manifesting as jaundice and coagulopathy, complicated within 4 weeks by ascites and/or encephalopathy in patients with previously diagnosed or undiagnosed chronic liver disease and is associated with a high 28-day mortality. we comparatively studied heamatological, biochemical profile and prognostic scores and their authenticity in survivors and nonsurvivors. This study was aimed to find out comparative differences in hematological and biochemical parameters and evaluate authenticity of different prognostic scores
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.018
      Issue No: Vol. 7 (2017)
       
  • Viral Hepatitis-Related Acute Liver Failure is not Associated With
           Long-Term Complications
    • Authors: Shalimar; Saurabh Kedia, Deepak Gunjan, Baibaswata Nayak, Harpreet Kaur, Nancy Kalra, Mousumi Mahanta, Subrat K. Acharya
      Abstract: Background and Aim: The long-term outcomes of survivors of viral hepatitis-related acute liver failure (ALF) are not known. The aim was to evaluate the long-term outcomes and liver-related morbidities in viral hepatitis-related ALF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.017
      Issue No: Vol. 7 (2017)
       
  • Prognostic Performance of ‘Integrated-Meld’, ‘Modified-CTP’ and
           Other Prediction Models in a Prospective Cohort of ACLF Patients
    • Authors: Rathan C. Joseph; Sandeep Narayanan, Aniruddha P.H. Singh, Varun Tadkalkar, Gaurav Kapoor, Rajendra Gunjal, Shanid A. Sathar, Sandesh Kolassery, Krishnadas Devadas
      Abstract: Background & Aim: Since ACLF is a specific syndrome characterized by high short-term mortality, defining early and accurate prognostic factors is of critical importance. The past two decades have witnessed an array of prediction models apart from MELD and CTP, that have been developed to assess the prognosis in End stage Liver disease, including a model of MELD-sodium (MELD-Na), MELD to sodium ratio (MESO), an integrated MELD (iMELD) and modified CTP (mCTP). Only a few studies have validated these models externally, in patients with ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.016
      Issue No: Vol. 7 (2017)
       
  • Role of Bedside Ultrasound Guided Measurement of Optic Nerve Sheath
           Diameter in Children With Acute Liver Failure—A Prospective
           Observational Pilot Study
    • Authors: Mridul C. Das; Anshu Srivastava, Surender K. Yachha, Ujjal Poddar, Rajanikant Yavad
      Abstract: Background and Aim: Early detection of intracranial hypertension (ICH) by non-invasive methods can improve the outcome in acute liver failure (ALF). Our study evaluated (i) feasibility and role of ultrasound (USG) guided measurement of optic nerve sheath diameter (ONSD) in ALF children and healthy controls, (ii) correlation between ONSD and hepatic encephalopathy (HE), international normalized ratio [INR] and blood ammonia [BA]).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.015
      Issue No: Vol. 7 (2017)
       
  • Effect of Plasmapheresis on vWF and ADAMTS13 in Acute on Chronic Liver
           Failure (ACLF)
    • Authors: Joy Vargese; Deepti Sachan, Mouleeswaran Sampath, Mayank Jain, Pushkala Subramanian, Jayanthi Venkataraman
      Abstract: Background & Aim: Rise in Von Willebrand Factor (vWF) antigen (Ag) levels and fall in ADAMTS13 levels has been studied in various liver disorders. However, there is no data on therapeutic measures to modulate this imbalance and improve clinical outcomes in acute on chronic liver failure (ACLF) patients. Aim of the study was to assess the relation between vWF(Ag) level and clinical/biochemical parameters in ACLF patients using therapeutic plasma exchange (TPE).
      Citation: Journal of Clinical and Experimental Hepatology 7, (2017)
      PubDate: 2017-07
      DOI: 10.1016/j.jceh.2017.05.014
      Issue No: Vol. 7 (2017)
       
  • Safety and Efficacy of Sofosbuvir and Daclatasvir for Hepatitis C Virus
           Infection in Patients with β-Thalassemia Major
    • Authors: Rajiv Mehta; Mayank Kabrawala, Subhash Nandwani, Pankaj Desai, Vishwa Bhayani, Sanjay Patel, Viral Parekh
      Abstract: β-thalassemia major patients are susceptible to hepatitis C virus (HCV) infection owing to life-long dependency for blood-transfusion. Moreover, this patient population is at risk of progression of liver fibrosis or development of cirrhosis as a consequence of both iron overload and HCV infection. Hence, this study was carried out to evaluate efficacy and safety of the combination regimen of sofosbuvir and daclatasvir for HCV infection in β-thalassemia major patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-14
      DOI: 10.1016/j.jceh.2017.06.002
       
  • Effect of Sofosbuvir Plus Daclatasvir in Hepatitis C Virus Genotype-4
           Patients: Promising Effect on Liver Fibrosis
    • Authors: Asmaa M. Abdel-Aziz; Mohamed A. Ibrahim, Azza A. El-Sheikh, Maha Y. Kamel, Nagwa M. Zenhom, Salam Abdel-Raheim, Hisham Abdelhaleem
      Abstract: The effect of sofosbuvir and daclatasvir in treatment of genotype 4 hepatitis C (HCV) virus is not well documented. This study investigated the safety and efficacy of sofosbuvir plus daclatasvir with or without ribavirin in treatment of HCV genotype 4 patients. The impact of therapy on liver fibrosis as well as the role of IL18 polymorphism in therapeutic outcome was assessed.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-07
      DOI: 10.1016/j.jceh.2017.06.006
       
  • Increased Incidence of Post-transplant Lymphoproliferative Disorder in
           Autoimmune Liver Disease: An Irish National Experience
    • Authors: Ahmed Abu-Shanab; Yasser Ged, Naeem Ullah, Diarmaid Houlihan, Aiden McCormick
      Abstract: Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication post solid organs transplant. PTLD represents a broad spectrum of abnormalities ranging from an infectious mononucleosis like illness to malignant lymphoma.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-06
      DOI: 10.1016/j.jceh.2017.05.209
       
  • Sofosbuvir and Ribavirin for 24 Weeks Is An Effective Treatment Option for
           Recurrent Hepatitis C Infection After Living Donor Liver Transplantation
    • Authors: Anil C. Anand; Shaleen K. Agarwal, Hitendra K. Garg, Sudeep Khanna, Subhash Gupta
      Abstract: Recurrent hepatitis C virus (HCV) has been a serious problem after liver transplantation (LT). We report our experience of 24-week therapy with sofosbuvir (SOF) and ribavirin (RBV) in post-LT recurrent HCV in living donor liver transplantation (LDLT) setting in South Asia.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-06
      DOI: 10.1016/j.jceh.2017.06.007
       
  • Prevalence of and Factors Associated With Minimal Hepatic Encephalopathy
           in Patients With Cirrhosis of Liver
    • Authors: Abhijith Bale; C. Ganesh Pai, Shiran Shetty, Girisha Balaraju, Anurag Shetty
      Abstract: Minimal hepatic encephalopathy (MHE), though highly prevalent, is a frequently underdiagnosed complication of cirrhosis of the liver. Because lack of time is reported as the major reason for non-testing, identifying patients at high risk of MHE would help in targeting them for screening. We aimed to determine the factors associated with MHE to help identify patient subgroups with a higher risk of MHE for targeted screening.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-01
      DOI: 10.1016/j.jceh.2017.06.005
       
  • Impact of Direct Acting Antiviral Therapy for Treatment of Hepatitis C
           Genotypes 1, 3 and 4: A Real Life Experience from India
    • Authors: Varun Mehta; Ramit Mahajan, Vandana Midha, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Anand Malhotra, Aslam Parvez, Ajit Sood
      Abstract: To assess impact of direct acting antiviral (DAA) therapies for treatment of hepatitis C virus (HCV) genotypes 1, 3 and 4 in a real-world cohort from India.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-01
      DOI: 10.1016/j.jceh.2017.06.003
       
  • Living Donor Liver Transplantation Using Small-for-Size Grafts: Does Size
           Really Matter'
    • Authors: Pulkit Sethi; Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
      Abstract: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR)>0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-27
      DOI: 10.1016/j.jceh.2017.06.004
       
  • Natural History of Cirrhosis of Liver after First Decompensation: A
           Prospective Study in India
    • Authors: Apurva S. Shah; Deepak N. Amarapurkar
      Abstract: As liver cirrhosis is a dynamic condition, it is possible to improve survival in decompensated cirrhosis. Hence, we planned a prospective study to determine the natural history of cirrhosis after first decompensation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-26
      DOI: 10.1016/j.jceh.2017.06.001
       
  • Role of Indocyanine Green in Predicting Post-Transarterial
           Chemoembolization Liver Failure in Hepatocellular Carcinoma
    • Authors: Shalimar; Sushil Jain, Shivanand R. Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B. Paul, Subrat K. Acharya
      Abstract: Post-transarterial chemoembolization (TACE) liver failure (LF) is common in patients with hepatocellular carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of indocyanine green (ICG) in prediction of post-TACE LF.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-16
      DOI: 10.1016/j.jceh.2017.05.012
       
  • Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis
           B Related Liver Diseases and Cryptogenic Cirrhosis
    • Authors: Siddharth Kapahtia; Rajib K. Hazam, Mohammad Asim, Vijay K. Karra, Soumya J. Chowdhury, Bhudev C. Das, Premashis Kar
      Abstract: Progression of hepatitis B virus infection (HBV) might be affected by host genetic factors. The present study was undertaken to study the role of glutathione S-transferases (GST)-M1 and T1 gene polymorphisms in different stages of HBV infection: HBV inactive carrier, chronic hepatitis B and cirrhosis, and cryptogenic cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-11
      DOI: 10.1016/j.jceh.2017.05.208
       
  • Middle Hepatic Vein Bleed During Donor Hepatectomy: Technique for Safe
           Practice
    • Authors: Madhusudhanan Jegadeesan; Neerav Goyal, Subash Gupta
      Abstract: Safe performance of donor hepatectomy is crucial for sustainability of a living donor liver transplantation (LDLT) program. Middle hepatic vein (MHV) is always encountered during parenchymal transection irrespective of right or left donor hepatectomies. Here we present a safe and effective technique for tackling MHV bleed during LDLT from a single centre experience.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-02
      DOI: 10.1016/j.jceh.2017.05.008
       
  • Prevalence and Characteristics of Hepatitis Delta Virus Infection in a
           Tertiary Hospital Setting in Cameroon
    • Authors: Henry N. Luma; Servais A.F.B. Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B. Nko’Ayissi, Dominique N. Noah
      Abstract: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-01
      DOI: 10.1016/j.jceh.2017.05.010
       
  • Bone Health and Impact of Tenofovir Treatment in Men with Hepatitis-B
           Related Chronic Liver Disease
    • Authors: Kattiparambil G. Sajith; Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E. Eapen, Thomas V. Paul
      Abstract: Chronic liver disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.jceh.2017.05.009
       
  • Long Term Outcomes of Patients with Significant Biliary Obstruction Due to
           Portal Cavernoma Cholangiopathy and Extra-Hepatic Portal Vein Obstruction
           (EHPVO) With No Shuntable Veins
    • Authors: Akash Shukla; Amit Gupte, Vedant Karvir, Prashant Dhore, Shobna Bhatia
      Abstract: The natural history of portal cavernoma cholangiopathy (PCC) in patients with significant biliary obstruction (SBO) who cannot undergo shunt surgery, is not known. We therefore, analyzed data of patients of extra-hepatic portal venous obstruction (EHPVO) with PCC.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.jceh.2017.04.003
       
  • Echocardiographic and Electrocardiographic Predictors of Adverse Outcomes
           in Spontaneous Bacterial Peritonitis
    • Authors: Mahek Shah; Soumya Patnaik, Obiora Maludum, Shantanu Patil, Toni Anne De Venecia, Vincent M. Figueredo
      Abstract: Patients with cirrhosis who develop spontaneous bacterial peritonitis (SBP) suffer from cirrhotic cardiomyopathy which is characterized by impaired contractility in response to stress despite a relatively normal resting cardiac output. We hypothesized that electrocardiographic and echocardiographic information would help prognosticate patients developing SBP in addition to existing scoring systems.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.007
       
  • Simple Anthropometric Indices are Useful for Predicting Non-alcoholic
           Fatty Liver Disease [NAFLD] in Asian Indians
    • Authors: Ayaskanta Singh; Sasmita Parida, Jimmy Narayan, Preetam Nath, Pradeep K. Padhi, Girish K. Pati, Prasanta K. Parida, Chudamani Meher, Omprakash Agrawal, Shivaram P. Singh
      Abstract: With the rising prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder in both developed and developing nations. Several studies on NAFLD have described waist circumference, a surrogate marker of visceral fat accumulation and waist height ratio as a better screening tool for NAFLD and metabolic syndrome than body mass index (BMI). We conducted this study to assess simple abdominal obesity indices as a predictor of NAFLD and determine the appropriate cut-off levels with reference to NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.005
       
  • Impact of Acute Kidney Injury on Mortality of Patients Hospitalized for
           Complications of Cirrhosis
    • Authors: Anantha Nuthalapati; Nicholas Schluterman, Anuj Khanna, Deborah Greenberg, Paul J. Thuluvath
      Abstract: The mortality of hospitalized patients for complications of cirrhosis is very high. We examined the independent predictors of mortality, particularly the impact of increments in creatinine, in 339 consecutive patients (636 admissions) who were admitted for complications of cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.004
       
  • Toward a Better Definition of Acute-on-Chronic Liver Failure
    • Authors: Ajay Duseja; Shivaram P. Singh
      Abstract: Acute-on-chronic liver failure (ACLF) has been defined differently in the East and West. The definitions given by Asian Pacific association for the study of liver (APASL) and American association for the study of liver (AASLD) and European association for the study of liver (EASL) working group have fundamental deficiencies and contradictions and do not encompass all patients with ACLF seen in the East and West. Although the World Gastroenterology Organisation (WGO) working party attempted to provide an improved definition but this too is not appropriate.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.002
       
  • Cholemic or Bile Cast Nephropathy in a Child with Liver Failure
    • Authors: Vikrant Sood; Bikrant B. Lal, Suman Lata, Archana Rastogi, Seema Alam
      Abstract: Cholemic or bile cast nephropathy is an under-reported entity characterized by acute renal dysfunction in patients with hepatic insult. Limited literature is available regarding its clinical presentation, pathogenesis and prognosis. We hereby present a pediatric case who presented with acute on chronic liver failure with renal dysfunction secondary to cholemic nephropathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-24
      DOI: 10.1016/j.jceh.2017.05.006
       
  • Glycochenodeoxycholic Acid Does Not Increase Transforming Growth
           Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis
           in Myofibroblasts
    • Authors: Anna Wang; Dorothy Yu, Yuewen Gong, Jessie Garber, Gerald Y. Minuk
      Abstract: Primary sclerosing cholangitis (PSC) is a chronic, progressive hepatobiliary disorder characterized by extensive fibrosis and stricturing of the intra- and/or extra-hepatic bile ducts: Previous studies have documented low phosphatylcholine (PC) concentrations in PSC bile. The aim of this study was to determine whether low PC levels in bile facilitate toxic bile acid induced injury of biliary tract epithelial cells resulting in enhanced transforming growth factor-beta (TGF-β) expression and increased collagen synthesis by myofibroblasts.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.04.002
       
  • An Insight into Antibiotic Resistance to Bacterial Infection in Chronic
           Liver Disease
    • Authors: Mayank Jain; Joy Varghese, Tom Michael, Chandan Kumar Kedarishetty, Balajee G, Subramanian Swaminathan, Jayanthi Venkataraman
      Abstract: End stage liver disease leads to immune dysfunction which predisposes to infection. There has been a rise in antibiotic resistant infections in these patients. There is scanty data f from India or idea regarding the same.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.003
       
  • In Situ Splitting of the Cadaver Liver for Two Adult Recipients by LDLT
           Technique
    • Authors: Nilesh S. Patil; Neerav Goyal, Shishir Pareek, Mohammed Nayeem, Subhash Gupta
      Abstract: To expand the donor pool, split liver transplantation is conventionally performed for one adult and one pediatric recipient. Application of this technique for two adult recipients can produce remarkable impact on the waiting list. Proper donor and recipient selection is crucial for the favorable outcome following full-right and full-left liver split. Right lobe adult to adult living donor liver transplantation (LDLT) is essentially a full right and full left split. However, LDLT techniques have not been used for full right and left split.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.001
       
  • Hemophagocytic Lymphohistiocytosis Masquerading as Acute Liver Failure: A
           Single Center Experience
    • Authors: Nitin Jagtap; Mithun Sharma, Gupta Rajesh, Padaki Nagaraja Rao, Sekaran Anuradha, Manu Tandan, Mohan Ramchandani, Duvvuru Nageshwar Reddy
      Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disorder of extreme inflammation and unregulated immune response which require prompt recognition and early introduction of definitive therapy. HLH can present with wide range of hepatic dysfunction ranging from mild elevation of transaminases to liver failure. This study is carried out to describe the clinical and laboratory presentation of HLH.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-15
      DOI: 10.1016/j.jceh.2017.01.119
       
  • Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases
    • Authors: Narendra S. Choudhary; Vijay Bodh, Shraddha Chaudhari, Neeraj Saraf, Sanjiv Saigal
      Abstract: Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-02
      DOI: 10.1016/j.jceh.2017.01.001
       
  • Results of Portosystemic Shunt Embolization in Selected Patients with
           Cirrhosis and Recurrent Hepatic Encephalopathy
    • Authors: Narendra S. Choudhary; Sanjay Saran Baijal, Sanjiv Saigal, Amit Agarwal, Neeraj Saraf, Rohit Khandelwal, Vaibhav Jain, Anubhav Harish Khandelwal, Abhay Kapoor, Deepak Jain, Smurti R. Misra, Rajesh Puri, Randhir Sud, Arvinder S. Soin
      Abstract: Large portosystemic shunts (PSSs) may lead to recurrent encephalopathy in patients with cirrhosis and embolization of these shunts may improve encephalopathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-27
      DOI: 10.1016/j.jceh.2017.03.012
       
  • Characterization of Cerebral Edema in Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Chirag K. Ahuja, Swastik Agrawal, Madhu Chopra, Naveen Kalra, Ajay Duseja, Sunil Taneja, Niranjan Khandelwal, Yogesh Chawla
      Abstract: The nature of cerebral edema in acute-on-chronic liver failure (ACLF) is not well studied. We aimed to characterize cerebral edema in ACLF using magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-25
      DOI: 10.1016/j.jceh.2017.04.001
       
  • Brain Microstructural Correlates of Cognitive Dysfunction in Clinically
           and Biochemically Normal Hepatitis C Virus Infection
    • Authors: Ajay Kumar; Amar Deep, Rakesh K. Gupta, Virendra Atam, Samir Mohindra
      Abstract: This study examined correlates of the brain's neurocognitive performance among clinically and biochemically normal adult patient with hepatitis C virus (HCV). We hypothesized that anti-HCV positive individuals would demonstrate structural brain abnormalities and neurocognitive dysfunction as well as the changes in cell component and extracellular space in the white matter regions of brain in asymptomatic HCV infection by using diffusion tensor tractrography (DTT) metrics.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-24
      DOI: 10.1016/j.jceh.2017.03.011
       
  • Thromboelastography for Assessing the Risk of Bleeding in Patients With
           Cirrhosis—Moving Closer
    • Authors: Vaibhav Somani; Deepak Amarapurkar, Apurva Shah
      Abstract: Conventional coagulation tests (CCTs) in patients with cirrhosis only assess procoagulant factors and are poor predictors of bleeding risk. In spite of this knowledge, they are routinely used prior to invasive procedures, and attempts are made to correct these abnormalities before invasive procedures. These practices are not supported by the evidence and are harmful to the patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-21
      DOI: 10.1016/j.jceh.2017.03.001
       
  • Role of Human Wharton's Jelly Derived Mesenchymal Stem Cells (WJ-MSCs) for
           Rescue of d-Galactosamine Induced Acute Liver Injury in Mice
    • Authors: Raghu Ramanathan; Secunda Rupert, Sakthivel Selvaraj, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
      Abstract: Mesenchymal stem cells (MSCs) are multipotent precursor cells having self-renewal ability making them a candidate for use in regenerative medicine. Acute liver injury results in sudden loss of hepatic function leading to organ failure. Liver transplantation is often required to salvage patients with acute liver failure. Due to shortage of organs, identification of alternate method is the need of the hour. In view of this, an attempt has been made to check the regenerative ability of WJ-MSCs (wharton's jelly derived MSC) in mice models for acute liver injury.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-20
      DOI: 10.1016/j.jceh.2017.03.010
       
  • Transient Elastography (Fibroscan) in Patients with Non-cirrhotic Portal
           Fibrosis
    • Authors: Praveen Sharma; Rachit Agarwal, Shashi Dhawan, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      Abstract: Non-cirrhotic portal hypertension (NCPH) is a common cause of variceal bleed in developing countries. Transient elastography (TE) using Fibroscan is a useful technique for evaluation of fibrosis in patients with liver disease. There is a paucity of studies evaluating TE in patients with Non-cirrhotic portal fibrosis (NCPF) and none in Asian population. Aim of this study was to evaluate role of TE in NCPF.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-04
      DOI: 10.1016/j.jceh.2017.03.002
       
  • Comparative Study of Community Acquired and Nosocomial Spontaneous
           Bacterial Peritonitis and its Variants in 150 Patients
    • Authors: Girisha Balaraju; Mallikarjun Patil, Adarsh C. Krishnamurthy, Dheeraj Karanth, Harshad Devarbhavi
      Abstract: Nosocomial acquisition of spontaneous bacterial peritonitis (SBP) is debated as having a different microbial etiology and prognosis. Identification of clinical, laboratory predictors of mortality and appropriate empirical antimicrobial selection is necessary to prevent early mortality and morbidity. We aimed to find the clinical and bacteriological profile in nosocomial and community acquired SBP and its variants, and the predictors of mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-03
      DOI: 10.1016/j.jceh.2017.03.005
       
  • Comparison of Contrast Enhanced Ultrasound With Contrast Enhanced Computed
           Tomography for the Diagnosis of Hepatocellular Carcinoma
    • Authors: Sandeep Moudgil; Naveen Kalra, Nidhi Prabhakar, Radha Krishan Dhiman, Arunanshu Behera, Yogesh Kumar Chawla, Niranjan Khandelwal
      Abstract: The most common primary malignant tumor of liver is hepatocellular carcinoma (HCC). The highest risk of developing HCC is seen in patients of cirrhosis. Ultrasound is used for surveillance in these patients. This study evaluates the role of contrast enhanced ultrasound (CEUS) in the diagnosis of HCC and compares CEUS to contrast enhanced computed tomography (CECT).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-29
      DOI: 10.1016/j.jceh.2017.03.003
       
  • Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron
           Overload Syndrome
    • Authors: Gyanendra K. Acharya; Hung-I Liao, Simona Frunza-Stefan, Ronakkumar Patel, Moe Khaing
      Abstract: Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-28
      DOI: 10.1016/j.jceh.2017.03.006
       
  • A Rare Case of Primary Sarcomatous Hepatocellular Carcinoma Without
           Previous Anticancer Therapy
    • Authors: Suvradeep Mitra; Saumya Gupta, Divya Dahiya, Uma N. Saikia
      Abstract: Primary sarcomatous hepatocellular carcinoma (PSHCC) is a rare and aggressive variety of hepatocellular carcinoma (HCC). The recent evidence suggests that anticancer therapy promotes the dedifferentiation of the carcinomatous component and is largely responsible for this aggressive variant of HCC. However, in the absence of any anticancer therapy, occurrence of PSHCC is extremely rare. Herein, we present a rare case report of a 65 year old male patient, with a hepatitis B positive status, presenting with PSHCC without any history of anticancer therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-24
      DOI: 10.1016/j.jceh.2017.03.008
       
  • Is Portal Venous Pressure Or Porto Systemic Gradient Really A Harbinger of
           Poor Outcomes After Living Donor Liver Transplantation'
    • Authors: Amol Vijay Kanetkar; Dinesh Balakrishnan, Sudhindran Sudhindran, Puneet Dhar, Unnikrishnan Gopalakrishnan, Ramachandran Menon, Othiyil Vayoth Sudheer
      Abstract: Portal hyperperfusion as a cause of small for size syndrome (SFSS) after living donor liver transplantation (LDLT) remains controversial. Portal venous pressure (PVP) is often measured indirectly and may be confounded by central venous pressure (CVP).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-21
      DOI: 10.1016/j.jceh.2017.01.114
       
 
 
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