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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.142]   [H-I: 3]   [2 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [2801 journals]
  • A Rare Presentation of Leishmaniasis
    • Authors: Ritesh Prajapati; Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Shashi Dhawan, Anil Arora
      Abstract: Leishmaniasis or kala-azar is a protozoan disease that can present as cutaneous, mucocutaneous, visceral, and disseminated disease. In India, it is usually localized in distinct areas of Bihar, Jharkhand, West Bengal, and parts of Eastern Uttar Pradesh. Visceral leishmaniasis (VL) involves the visceral organs, mainly the liver, the spleen and bone marrow. VL is characterized by prolonged fever, massive splenomegaly, weight loss, progressive anemia, pancytopenia, and hypergammaglobulinemia, and can be complicated by serious infections.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-23
      DOI: 10.1016/j.jceh.2016.01.001
       
  • Liver Transplantation in India: At the Crossroads
    • Authors: Sanjay Nagral; Aditya Nanavati, Aabha Nagral
      Pages: 329 - 340
      Abstract: As the liver transplant journey in India reaches substantial numbers and suggests quality technical expertise, it is time to dispassionately look at the big picture, identify problems, and consider corrective measures for the future. Several features characterize the current scenario. Although the proportion of deceased donor liver transplants is increasing, besides major regional imbalances, the activity is heavily loaded in favor of the private sector and live donor transplants. The high costs of the procedure, the poor participation of public hospitals, the lack of a national registry, and outcomes reporting are issues of concern.
      Citation: Journal of Clinical and Experimental Hepatology 5, 4 (2015)
      PubDate: 2015-12
      DOI: 10.1016/j.jceh.2015.11.001
      Issue No: Vol. 5, No. 4 (2015)
       
  • Journal of Clinical and Experimental Hepatology 5, 4 (2015)
    • Authors: Vivek A. Saraswat; Gaurav Pandey
      First page: 348
      Abstract: This, one-of-its kind book, is an excellent and timely state-of-the-art review of Hepatitis C in December 2015. Though billed as ‘A Complete Guide for Patients and Families’, this book is actually a complete guide to the student internist, the family physician, other professionals caring for hepatitis C patients and even the non-hepatologist caring for patients who suffer from hepatitis C, among other problems. Its simple, easy-to-follow language and uncluttered syntax makes it the ideal companion volume to more comprehensive tomes on hepatitis C and for understanding the torrent of literature gushing out of the hepatitis C pipeline that is in flood since 2011.
      PubDate: 2015-12
      DOI: 10.1016/j.jceh.2015.12.004
      Issue No: Vol. 5, No. 4 (2015)
       
  • Dopamine and Furosemide for the Treatment of Hepatorenal Syndrome: A
           Reappraisal or Just Smoke and Mirrors?
    • Authors: Salvatore Piano; Paolo Angeli
      Abstract: Patients with advanced cirrhosis have a high to develop extrahepatic organ failures. Renal failure is common in patients with advanced cirrhosis and hepatorenal syndrome (HRS) represents the most life-threatening type of renal failure in these patients.1 Until 30 years ago, no effective treatment of HRS was available and short-term mortality was almost 100% in these patients.2 With the advent of orthotopic liver transplantation (OLT), HRS became an indication to OLT since it was shown that HRS resolved in most of the liver transplant recipients with a deep impact on survival.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-22
      DOI: 10.1016/j.jceh.2015.12.003
       
  • Hepatobiliary Quiz—16 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-22
      DOI: 10.1016/j.jceh.2015.12.001
       
  • Pyoderma Gangrenosum—A New Manifestation of Wilson Disease?
    • Authors: George Naiem Ibrahiem Freg; Venisha Shah, Aabha Nagral, Ajay Jhaveri
      Abstract: Seventeen year old girl, a known case of Wilson disease presented to us with a non-healing skin ulcer followed by appearance of jaundice, ascites and progressive fatigue of 1 month duration. She was diagnosed to have Wilson disease 5 years back and had been well controlled on d-penicillamine. On enquiry, she was found to be noncompliant with her medication in the preceding 6 months. On examination, she had severe pallor, icterus with moderate ascites and oedema feet. Investigations revealed severe haemolytic anemia and deranged liver function.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-21
      DOI: 10.1016/j.jceh.2015.11.005
       
  • Hepatobiliary Quiz (Answers)—16 (2015)
    • Authors: Sahaj Rathi; Radha K. Dhiman
      Abstract: Liver transplant recipients are twice as prone to develop malignancies as compared to the general population.1–4 The risk is most in patients transplanted for alcohol-related liver disease or primary sclerosing cholangitis (PSC).3–5 The most common malignancies in this population include dermatological cancers, post-transplantation lymphoproliferative disease and gastrointestinal, lung, oropharyngeal and gynecological solid tumors.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-21
      DOI: 10.1016/j.jceh.2015.12.002
       
  • PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and Prothrombin 20210A in
           Splanchnic Vein Thrombosis: Analysis of Individual Patient Data From Three
           Prospective Studies
    • Abstract: There are no univocal opinions on the role of genetic thrombophilia on splanchnic vein thrombosis (SVT). We defined genetic thrombophilia the presence of one of these thrombophilic genetic factors (THRGFs): PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q, and prothrombin 20210A.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.002
       
  • Use of Non-selective Beta-blockers in Decompensated Cirrhosis: Controversy
           Continues
    • Authors: Shalimar
      Abstract: J Hepatol. Online first (doi:10.1016/j.jhep.2015.10.018). Reference: JHEPAT 5868
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.003
       
  • Changes in Liver Volume in Patients with Chronic Hepatitis C Undergoing
           Antiviral Therapy
    • Authors: Julie A. Fitzpatrick; Jin Un Kim, Jeremy F.L. Cobbold, Mark J.W. McPhail, Mary M.E. Crossey, Aluel A. Bak-Bol, Ashraf Zaky, Simon D. Taylor-Robinson
      Abstract: Liver volumetric analysis has not been used to detect hepatic remodelling during antiviral therapy before. We measured liver volume (LV) changes on volumetric magnetic resonance imaging during hepatitis C antiviral therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-18
      DOI: 10.1016/j.jceh.2015.11.004
       
  • Primary Liver Sinusoidal Non-Hodgkin's Lymphoma Presenting as Acute Liver
           Failure
    • Authors: Aabha Nagral; Ajay Jhaveri, Vilesh Kalthoonical, Ganapathi Bhat, Pravin Mahajan, Anita Borges
      Abstract: We describe a case of a middle-aged woman, who presented to us with fever, anorexia, abdominal distension from a massive hepatomegaly, low hemoglobin, and acute liver failure. A liver biopsy revealed B cell non-Hodgkin's lymphoma predominantly in the sinusoids with CD10, CD20, and Bcl-2 positive on immunohistochemistry. She initially responded well to chemotherapy but succumbed 6 months later to the recurrence of disease. Sinusoidal non-Hodgkin's lymphoma of the liver should be considered in the differential diagnosis of a patient with large hepatomegaly presenting with acute liver failure.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-12-15
       
  • Magnetic Resonance Spectroscopy: Principles and Techniques: Lessons for
           Clinicians
    • Authors: Joshua M. Tognarelli; Mahvish Dawood, Mohamed I.F. Shariff, Vijay P.B. Grover, Mary M.E. Crossey, I. Jane Cox, Simon D. Taylor-Robinson, Mark J.W. McPhail
      Abstract: Magnetic resonance spectroscopy (MRS) provides a non-invasive ‘window’ on biochemical processes within the body. Its use is no longer restricted to the field of research, with applications in clinical practice increasingly common. MRS can be conducted at high magnetic field strengths (typically 11–14T) on body fluids, cell extracts and tissue samples, with new developments in whole-body magnetic resonance imaging (MRI) allowing clinical MRS at the end of a standard MRI examination, obtaining functional information in addition to anatomical information.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-30
       
  • Variceal Banding: A Lesser-Known Complication
    • Authors: Ashish Kumar Jha; Vishwa Mohan Dayal, Baraq Ahmed, Uday Kumar, Sharad Kumar
      Abstract: Band ligation is the cornerstone of the treatment of esophageal varices. Band ligation is one of the most commonly performed endoscopic procedures. Although variceal banding is mostly a safe procedure, it may be complicated by serious adverse event.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
       
  • Donor Factors Including Donor Risk Index Predict Fibrosis Progression,
           Allograft Loss, and Patient Survival following Liver Transplantation for
           Hepatitis C Virus
    • Authors: Arun Jesudian; Sameer Desale, Jonathan Julia, Elizabeth Landry, Christopher Maxwell, Bhaskar Kallakury, Jacqueline Laurin, Kirti Shetty
      Abstract: The utilization of liver transplantation (LT) is limited by the availability of suitable organs. This study aimed to assess the impact of the donor risk index (DRI) and other donor characteristics on fibrosis progression, graft, and patient survival in hepatitis C virus (HCV)-infected LT recipients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-26
       
  • “Hockey Stick” may Strike Back: Hepatocellular Carcinoma on
           Noncirrhotic Liver as a Late Toxicity of Lombo-Aortic Radiotherapy for
           Seminoma. A Review Triggered by an Unusual Case
    • Authors: Clement Korenbaum; Philippe Barthelemy, Alina Onea, Pierre Salze, Jean-Emmanuel Kurtz
      Abstract: Most patients with testicular seminoma have been treated with a curative intent for decades. Second cancers after radiotherapy for testicular seminoma before 1990 are a growing issue, and are related to previous generation of dose planning and delineating strategies. Among those cancers, hepatocellular carcinoma is an extremely rare occurrence, especially when affecting patients with healthy, noncirrhotic liver. Here, we describe such a case in a patient of our institution, and subsequently review the relevant literature and large epidemiologic studies.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
       
  • Liver Transplantation After Bone Marrow Transplantation for End Stage
           Liver Disease with Severe Hepatopulmonary Syndrome in Dyskeratosis
           Congenita: A Literature First
    • Authors: Shyam Sunder Mahansaria; Senthil Kumar, Kishore G.S. Bharathy, Sachin Kumar, Viniyendra Pamecha
      Abstract: Dyskeratosis congenita is a multisystem genetic disorder. Although hepatic involvement is reported in about 7% of patients with dyskeratosis congenita, it is not well characterized and often attributed to hemochromatosis from frequent blood transfusions. A few case reports describe cirrhosis and hepatic cell necrosis in affected individuals in autosomal dominant pedigrees. Bone marrow failure and malignancies are the principal causes of death in dyskeratosis congenita. We describe the first case of living donor liver transplantation, in dyskeratosis congenita for decompensated cirrhosis with portal hypertension.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-11-24
       
  • Multiplex Reverse Transcriptase-PCR for Simultaneous Detection of
           Hepatitis B, C, and E Virus
    • Authors: Gunjan Garg; Deepak Kumar, Mohammad Asim, Syed Akhtar Husain, Bhudev C. Das, Premashis Kar
      Abstract: The hepatitis B virus (HBV), HCV, and HEV may occur as singly or concurrently in patients of different kind of liver disease. The rapid, reliable, and cost-effective screening of these pathogens is required for the large epidemiological studies. Therefore, a study has been planned to develop a multiplex Reverse Transcriptase-PCR assay which can be used for the screening of maximum number of pathogens at a time.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-30
       
  • Indications of Liver Biopsy in the Era of Noninvasive Assessment of Liver
           Fibrosis
    • Authors: Deepak Amarapurkar; Anjali Amarapurkar
      Abstract: Liver biopsy (LB) has been used as diagnostic modality in liver diseases (LD). Over last two decades, there has been remarkable improvement in understanding of natural history, molecular diagnostics of viral hepatitis, genetic of LD, and also limitations of LB. There is current trend in avoiding LB in the management of various LDs.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-28
      DOI: 10.1016/j.jceh.2015.08.005
       
  • Role of Transient Elastography (Fibroscan) in Differentiating Severe Acute
           Hepatitis and Acute on Chronic Liver Failure
    • Authors: Praveen Sharma; Rinkesh Bansal, Abdul Matin, Pankaj Tyagi, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      Abstract: It is difficult to differentiate acute severe hepatitis (AH) with acute on chronic liver failure (ACLF). Aim was to study the role of transient elastography (Fibroscan) in identifying the patients with AH and ACLF.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-27
      DOI: 10.1016/j.jceh.2015.09.004
       
  • Driving Performance Among Patients with Cirrhosis Who Drove to Their
           Outpatient Hepatology Clinic Appointments
    • Authors: Paul J. Thuluvath; Anantha Nuthalapati, Jennifer Price, Anurag Maheshwari
      Abstract: Minimal hepatic encephalopathy (MHE) may adversely affect driving skills.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-15
      DOI: 10.1016/j.jceh.2015.09.003
       
  • Upper Gastrointestinal Bleed Following Percutaneous Liver Abscess Drainage
    • Authors: Hemanta K. Nayak; Vivek A. Saraswat, Samir Mohindra, Raghunandan Prasad, Arun Karyampudi
      Abstract: A 55-year-old male was admitted to a community hospital with right upper quadrant pain and fever for two weeks. Ultrasonography showed a large right lobe liver abscess (volume 350mm3), for which he received intravenous injection metronidazole 800mg thrice daily with injection ceftriaxone 1g twice daily for seven days without any improvement. A percutaneous drain was placed successfully in the liver abscess and drained creamy pus. One week later, the percutaneous catheter was removed after improvement of symptoms.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-10-14
      DOI: 10.1016/j.jceh.2015.06.009
       
  • Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians:
           A Case–Control Study
    • Authors: Shivaram P. Singh; Ayaskanta Singh, Debasis Misra, Bijay Misra, Girish K. Pati, Manas K. Panigrahi, Sanjib K. Kar, Pallavi Bhuyan, Kaumudee Pattnaik, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Manoroma Swain, Palok Aich
      Abstract: NAFLD has today emerged as the leading cause of liver disorder. There is scanty data on risk factors associated with NAFLD emanating from India. The present study was conducted to identify the risk factors associated with NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-29
      DOI: 10.1016/j.jceh.2015.09.001
       
  • Safety of Ascitic Paracentesis in Patients with Budd-Chiari Syndrome on
           Oral Anticoagulation and Elevated International Normalized Ratio
    • Authors: Harshad Devarbhavi; Arvind R. Murali
      Abstract: Anticoagulation is the standard of care in patients with Budd-Chiari Syndrome (BCS). Ascites is a common symptom in patients with BCS. Often such patients require paracentesis while taking oral anticoagulation concurrently. It is unclear whether paracentesis leads to increased bleeding in such patients or whether anticoagulation has to be temporarily suspended. We describe our experience with paracentesis in patients with BCS taking oral anticoagulation.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-15
      DOI: 10.1016/j.jceh.2015.08.004
       
  • Randomized Controlled Trial Comparing the Efficacy of Terlipressin and
           Albumin with a Combination of Concurrent Dopamine, Furosemide, and Albumin
           in Hepatorenal Syndrome
    • Authors: Siddharth Srivastava; Shalimar, Sreenivas Vishnubhatla, Shyam Prakash, Hanish Sharma, Bhaskar Thakur, Subrat K. Acharya
      Abstract: Terlipressin with albumin is recommended in hepatorenal syndrome (HRS). Terlipressin is expensive and not licensed in many countries. Alternative therapy is necessary. We compared the efficacy of terlipressin and albumin with concurrent low-dose dopamine, furosemide, and albumin in HRS.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-10
      DOI: 10.1016/j.jceh.2015.08.003
       
  • Acute-On-Chronic Liver Failure (ACLF) in Coastal Eastern India: “A
           Single-Center Experience”
    • Authors: Girish Kumar Pati; Ayaskanta Singh, Bijay Misra, Debasis Misra, Haribhakti Seba Das, Chittaranjan Panda, Shivaram Prasad Singh
      Abstract: Acute-On-Chronic liver failure (ACLF) is an emerging entity. The present study was undertaken to analyze the clinical profile and natural course of ACLF patients.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-09-01
      DOI: 10.1016/j.jceh.2015.08.002
       
  • Plasma Lipid Profiling in a Rat Model of Hepatocellular Carcinoma:
           Potential Modulation Through Quinolone Administration
    • Authors: Mohamed I.F. Shariff; Joshua M. Tognarelli, Matthew R. Lewis, Elizabeth J. Want, Fatma El Zahra Mohamed, Nimzing G. Ladep, Mary M.E. Crossey, Shahid A. Khan, Rajiv Jalan, Elaine Holmes, Simon D. Taylor-Robinson
      Abstract: The primary aim of this study was to characterise the blood metabolic profile of hepatocellular carcinoma (HCC) in a rat model, and the secondary aim was to evaluate the effect of the quinolone, norfloxacin on metabolic profiles and exploring the role that gut sterilisation may have on HCC development.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-07-29
      DOI: 10.1016/j.jceh.2015.07.205
       
  • Hepatitis C Virus (HCV) Infection in Patients with End Stage Renal
           Disease: A Study from a Tertiary Care Centre in India
    • Authors: Anil Arora; Naresh Bansal, Praveen Sharma, Vikas Singla, Varun Gupta, Pankaj Tyagi, Manish Malik, Ashish Kumar
      Abstract: Hepatitis C Virus (HCV) infection is common in patients with end stage renal disease (ESRD) and is an important cause of liver disease. We describe the demographic, clinical and biochemical profile of these patients from a tertiary care center of north India.
      Citation: Journal of Clinical and Experimental Hepatology (2015)
      PubDate: 2015-05-15
      DOI: 10.1016/j.jceh.2015.04.004
       
 
 
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