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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.283]   [H-I: 7]   [4 followers]  Follow
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [3051 journals]
  • Chronic Hepatitis C: Do Generics Work as Well as Branded Drugs'
    • Authors: Madhumita Premkumar; Gagandeep S. Grover, Radha K. Dhiman
      Pages: 253 - 261
      Abstract: India has a large share of the hepatitis C virus (HCV) burden of the world. Unsafe medical practices and blood transfusions are the leading modes of transmission of HCV in India. The commonest HCV genotype in India is genotype 3 followed by genotype 1. While directly acting antivirals (DAAs) agents have become available at reasonable rates in India, cost of therapy remains a major barrier for control of HCV in India. Generic DAAs have been proven to be cost-saving in prior studies. We examined data from various studies in India and elsewhere using generic DAAs, and evaluated whether they are equally efficacious as the branded drugs.
      Citation: Journal of Clinical and Experimental Hepatology 7, 3 (2017)
      PubDate: 2017-09
      DOI: 10.1016/j.jceh.2017.08.003
      Issue No: Vol. 7, No. 3 (2017)
  • Large Heterogeneous Calcified Masses in Liver: A Diagnostic Dilemma
    • Authors: Nidhi Prabhakar; Naveen Kalra, Arunanshu Behera, Ashim Das, Anupam Lal, Radha Krishan Dhiman, Niranjan Khandelwal
      Abstract: A 27-year-old female presented to our hospital with complaints of jaundice and epigastric pain. The patient had history of progressive cholestatic jaundice for the last 3 months. She was also suffering from continuous epigastric pain for the last 1 month. General physical examination revealed icterus. On palpation, hepatomegaly was noted. Laboratory investigations revealed mild anaemia (10g/dl), increased white blood counts (13,000/mm3) and normal platelet count (380×103/mm3). Liver function tests were abnormal (increased total serum bilirubin 8mg/dl, serum alkaline phosphatase 1000IU/L, serum alanine aminotransferase 110IU/L, aspartate aminotransferase 100IU/L).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-27
      DOI: 10.1016/j.jceh.2017.09.001
  • Diagnostic Value of Glypican3, Heat Shock Protein 70 and Glutamine
           Synthetase in Hepatocellular Carcinoma Arising in Cirrhotic and
           Non-Cirrhotic Livers
    • Authors: Preithy Uthamalingam; Ashim Das, Arunanshu Behra, Naveen Kalra, Yogesh Chawla
      Abstract: Histopathological distinction of various nodular lesions in liver with sufficient sensitivity and specificity is a challenge even in an expert set up. The panel of immunohistochemical markers composed of glutamine synthetase (GS), Glypican3 (GPC3) and heat shock protein 70 (HSP70) was recommended by the International Consensus Group for Hepatocellular Neoplasia group for the differentiation of high grade dysplastic nodule and early hepatocellular carcinoma (HCC). The panel has been extensively validated in the western population.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-26
      DOI: 10.1016/j.jceh.2017.09.005
  • Upper Gastrointestinal Bleed Due to Invasive Hepatocellular Carcinoma and
           Hepato-Gastric Fistula
    • Authors: Abhijith Bale; Shiran Shetty, Anurag Shetty, Girisha Balaraju, Cannanore Ganesh Pai
      Abstract: A 69-year-old man with cirrhosis of the liver, possibly secondary to nonalcoholic fatty liver disease (NAFLD) and multifocal hepatocellular carcinoma (HCC) post three sessions of transcatheter arterial chemoembolization (TACE) in the past 8 months presented with upper gastrointestinal (UGI) bleed. The last session of TACE was performed two months prior to the presentation. After initial hemodynamic resuscitation an UGI endoscopy was performed which showed a large antral opening at the lesser curvature of the stomach, 3–4cm proximal to the pylorus with an ulcer at its mouth (Figure 1).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-21
      DOI: 10.1016/j.jceh.2017.09.006
  • Endoscopic Ultrasound (EUS) Guided Fine Needle Aspiration: A New Modality
           to Diagnose Peritoneal Tuberculosis in Presence of Decompensated
           Cirrhosis—A Case Series and Review of Literature
    • Authors: Ravi Daswani; Ashish Kumar, Vikas Singla, Gagandeep Kaur, Praveen Sharma, Naresh Bansal, Anil Arora
      Abstract: The gold-standard for diagnosis is growth of Mycobacterium tuberculosis on ascitic fluid or peritoneal culture. Due to the non-specific signs and symptoms of disease, its early diagnosis is difficult, especially in patients with decompensated cirrhosis. The reported sensitivity of ascitic fluid is low and to obtain tissue for peritoneal biopsy in patients with cirrhosis is difficult. Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) is a good alternative to obtain peritoneal tissue for establishing the diagnosis of peritoneal TB.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-19
      DOI: 10.1016/j.jceh.2017.09.007
  • Matrix Metalloproteinases (MMPs) in Liver Diseases
    • Authors: Adnan Naim; Qiuwei Pan, Mirza S. Baig
      Abstract: Matrix metalloproteinases (MMPs) are proteinases capable of degrading components of the extracellular matrix and numerous nonmatrix proteins. MMPs along with tissue inhibitors of MMPs, have been implicated in the pathogenesis of liver diseases. Although, the precise mechanism-of-actions of MMPs in various liver related disorders is largely unknown, however, data from diverse experimental models indicate that these proteinases influence cellular activities including proliferation and survival, gene expression, as well as multiple aspects of inflammation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-18
      DOI: 10.1016/j.jceh.2017.09.004
  • Can Non-Selective Beta-Blockers (NSBBs) Prevent Enlargement of Small
           Esophageal Varices in Patients with Cirrhosis' A Meta-analysis
    • Authors: Ashish Kumar; Praveen Sharma, Shrihari A. Anikhindi, Ritesh Prajapati, Rachit Agarwal, Bhupendra Sharma, Naresh Bansal, Vikas Singla, Anil Arora
      Abstract: Non-selective beta-blockers (NSBBs) are recommended for prophylaxis of first variceal bleeding in patients of cirrhosis with large esophageal varices. However, the data is conflicting whether NSBBs can also prevent growth of small esophageal varices to large size.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-14
      DOI: 10.1016/j.jceh.2017.09.003
  • A Tale Of Two Diseases Or A Story Of Co-Existence: Are Obese
           Individuals’ Immune To Alcoholic Liver Disease'
    • Authors: Ankur Gupta
      Abstract: I read with interest the article by Mehta et al. in recent issue of the journal and wish to congratulate the authors for their study.1 This study may have implications in management of obese patients with alcoholic liver disease (ALD).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-14
      DOI: 10.1016/j.jceh.2017.09.002
  • Prevalence and Impact of Bacterial Infections in Children With Liver
           Disease—A Prospective Study
    • Authors: Rishi Bolia; Anshu Srivastava, Rungmei Marak, Surender K. Yachha, Ujjal Poddar
      Abstract: Risk of infections is increased in patients with acute liver failure (ALF) and decompensated chronic liver disease (DCLD). We evaluated the frequency, site, type and risk-factors for bacterial infections in children with ALF and DCLD and its effect on outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-10-07
      DOI: 10.1016/j.jceh.2017.08.007
  • Acute Exacerbation Of Autoimmune Hepatitis Mimicking Acute Viral
           Hepatitis—A Case Series and Review of Literature
    • Authors: Sunil Taneja; Pramod Kumar, Suvradeep Mitra, Ajay Duseja, Ranjana Minz, Ashim Das, Radha K. Dhiman, Yogesh Chawla
      Abstract: Acute exacerbation of autoimmune hepatitis (AIH) poses a significant challenge for diagnosis as it can mimic acute viral hepatitis especially in absence of autoantibodies and hypergammaglobulinemia.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-09-21
      DOI: 10.1016/j.jceh.2017.08.005
  • A Case of Acute-On-Chronic Liver Failure (ACLF) Due To An Uncommon Acute
           And Chronic Event
    • Authors: Swastik Agrawal; Baldev S. Rana, Suvradeep Mitra, Ajay Duseja, Ashim Das, Radha K. Dhiman, Yogesh Chawla
      Abstract: Acute on chronic liver failure (ACLF) is an acute worsening of patients with chronic liver disease resulting in liver failure. Usually these patients have cirrhosis as the underlying liver disease with alcohol being the most common etiology. Common hepatitic illnesses causing acute worsening in Indian patients of ACLF include alcoholic hepatitis, acute viral hepatitis related to hepatitis E virus and acute flare in chronic hepatitis B. We report an adult case of ACLF due acute viral hepatitis related to hepatitis A virus infection superimposed on nonalcoholic steatohepatitis without cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-09-10
      DOI: 10.1016/j.jceh.2017.08.006
  • Efficacy And Safety of Sofosbuvir Based Regimens For Treatment of
           Hepatitis C Recurrence After Living Donor Liver Transplantation: An
           Experience From India
    • Authors: Narendra S. Choudhary; Sanjiv Saigal, Dheeraj Gautam, Neeraj Saraf, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Arvinder S. Soin
      Abstract: Results of Sofosbuvir based regimens for hepatitis C (HCV) recurrence after liver transplantation are available from well-designed clinical trials. Most of the data is from deceased donor liver transplant (DDLT) setting, and data on “real world” experience for HCV recurrence after living donor liver transplantation (LDLT) is limited.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-09-08
      DOI: 10.1016/j.jceh.2017.08.004
  • Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood
    • Authors: Helene Johansson; Lisa-Mari Mörk, Meng Li, Anita L. Sandblom, Ingemar Björkhem, Jonas Höijer, Bo-Göran Ericzon, Carl Jorns, Stefan Gilg, Ernesto Sparrelid, Bengt Isaksson, Greg Nowak, Ewa Ellis
      Abstract: Bile acid homeostasis is essential and imbalance may lead to liver damage and liver failure. The bile acid induced intestinal factor fibroblast growth factor 19 (FGF19) has been identified as a key protein for mediating negative feedback inhibition of bile acid synthesis. The aim of the study was to define FGF19 and bile acid concentrations in portal and systemic blood in the fasted and postprandial state. We also addressed the question if physiological portal levels of FGF19 can be extrapolated from the concentration in systemic blood.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-08-09
      DOI: 10.1016/j.jceh.2017.07.001
  • Safety and Efficacy of Sofosbuvir and Daclatasvir for Hepatitis C Virus
           Infection in Patients with β-Thalassemia Major
    • Authors: Rajiv Mehta; Mayank Kabrawala, Subhash Nandwani, Pankaj Desai, Vishwa Bhayani, Sanjay Patel, Viral Parekh
      Abstract: β-thalassemia major patients are susceptible to hepatitis C virus (HCV) infection owing to life-long dependency for blood-transfusion. Moreover, this patient population is at risk of progression of liver fibrosis or development of cirrhosis as a consequence of both iron overload and HCV infection. Hence, this study was carried out to evaluate efficacy and safety of the combination regimen of sofosbuvir and daclatasvir for HCV infection in β-thalassemia major patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-14
      DOI: 10.1016/j.jceh.2017.06.002
  • Effect of Sofosbuvir Plus Daclatasvir in Hepatitis C Virus Genotype-4
           Patients: Promising Effect on Liver Fibrosis
    • Authors: Asmaa M. Abdel-Aziz; Mohamed A. Ibrahim, Azza A. El-Sheikh, Maha Y. Kamel, Nagwa M. Zenhom, Salam Abdel-Raheim, Hisham Abdelhaleem
      Abstract: The effect of sofosbuvir and daclatasvir in treatment of genotype 4 hepatitis C (HCV) virus is not well documented. This study investigated the safety and efficacy of sofosbuvir plus daclatasvir with or without ribavirin in treatment of HCV genotype 4 patients. The impact of therapy on liver fibrosis as well as the role of IL18 polymorphism in therapeutic outcome was assessed.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-07
      DOI: 10.1016/j.jceh.2017.06.006
  • Increased Incidence of Post-transplant Lymphoproliferative Disorder in
           Autoimmune Liver Disease: An Irish National Experience
    • Authors: Ahmed Abu-Shanab; Yasser Ged, Naeem Ullah, Diarmaid Houlihan, Aiden McCormick
      Abstract: Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication post solid organs transplant. PTLD represents a broad spectrum of abnormalities ranging from an infectious mononucleosis like illness to malignant lymphoma.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-06
      DOI: 10.1016/j.jceh.2017.05.209
  • Prevalence of and Factors Associated With Minimal Hepatic Encephalopathy
           in Patients With Cirrhosis of Liver
    • Authors: Abhijith Bale; C. Ganesh Pai, Shiran Shetty, Girisha Balaraju, Anurag Shetty
      Abstract: Minimal hepatic encephalopathy (MHE), though highly prevalent, is a frequently underdiagnosed complication of cirrhosis of the liver. Because lack of time is reported as the major reason for non-testing, identifying patients at high risk of MHE would help in targeting them for screening. We aimed to determine the factors associated with MHE to help identify patient subgroups with a higher risk of MHE for targeted screening.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-01
      DOI: 10.1016/j.jceh.2017.06.005
  • Impact of Direct Acting Antiviral Therapy for Treatment of Hepatitis C
           Genotypes 1, 3 and 4: A Real Life Experience from India
    • Authors: Varun Mehta; Ramit Mahajan, Vandana Midha, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Anand Malhotra, Aslam Parvez, Ajit Sood
      Abstract: To assess impact of direct acting antiviral (DAA) therapies for treatment of hepatitis C virus (HCV) genotypes 1, 3 and 4 in a real-world cohort from India.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-01
      DOI: 10.1016/j.jceh.2017.06.003
  • Living Donor Liver Transplantation Using Small-for-Size Grafts: Does Size
           Really Matter'
    • Authors: Pulkit Sethi; Manoj Thillai, Binoj Sivasankarapillai Thankamonyamma, Shweta Mallick, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran Narayana Menon, Sudhindran Surendran, Puneet Dhar, Sudheer Othiyil Vayoth
      Abstract: In living donor liver transplantation (LDLT), graft-to-recipient weight ratio (GRWR)>0.8% is perceived as the critical graft size. This lower limit of GRWR (0.8%) has been challenged over the last decade owing to the surgical refinements, especially related to inflow and outflow modulation techniques. Our aim was to compare the recipient outcome in small-for-size (GRWR0.8) and to determine the risk factors for mortality when small-for-size grafts (SFSG) were used.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-27
      DOI: 10.1016/j.jceh.2017.06.004
  • Natural History of Cirrhosis of Liver after First Decompensation: A
           Prospective Study in India
    • Authors: Apurva S. Shah; Deepak N. Amarapurkar
      Abstract: As liver cirrhosis is a dynamic condition, it is possible to improve survival in decompensated cirrhosis. Hence, we planned a prospective study to determine the natural history of cirrhosis after first decompensation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-26
      DOI: 10.1016/j.jceh.2017.06.001
  • Role of Indocyanine Green in Predicting Post-Transarterial
           Chemoembolization Liver Failure in Hepatocellular Carcinoma
    • Authors: Shalimar; Sushil Jain, Shivanand R. Gamanagatti, Saurabh Kedia, Bhaskar Thakur, Baibaswata Nayak, Harpreet Kaur, Deepak Gunjan, Shashi B. Paul, Subrat K. Acharya
      Abstract: Post-transarterial chemoembolization (TACE) liver failure (LF) is common in patients with hepatocellular carcinoma (HCC). No definitive objective parameters predict its occurrence. We assessed the role of indocyanine green (ICG) in prediction of post-TACE LF.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-16
      DOI: 10.1016/j.jceh.2017.05.012
  • Role of Glutathione S Transferase M1 and T1 Gene Polymorphism in Hepatitis
           B Related Liver Diseases and Cryptogenic Cirrhosis
    • Authors: Siddharth Kapahtia; Rajib K. Hazam, Mohammad Asim, Vijay K. Karra, Soumya J. Chowdhury, Bhudev C. Das, Premashis Kar
      Abstract: Progression of hepatitis B virus infection (HBV) might be affected by host genetic factors. The present study was undertaken to study the role of glutathione S-transferases (GST)-M1 and T1 gene polymorphisms in different stages of HBV infection: HBV inactive carrier, chronic hepatitis B and cirrhosis, and cryptogenic cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-11
      DOI: 10.1016/j.jceh.2017.05.208
  • Middle Hepatic Vein Bleed During Donor Hepatectomy: Technique for Safe
    • Authors: Madhusudhanan Jegadeesan; Neerav Goyal, Subash Gupta
      Abstract: Safe performance of donor hepatectomy is crucial for sustainability of a living donor liver transplantation (LDLT) program. Middle hepatic vein (MHV) is always encountered during parenchymal transection irrespective of right or left donor hepatectomies. Here we present a safe and effective technique for tackling MHV bleed during LDLT from a single centre experience.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-02
      DOI: 10.1016/j.jceh.2017.05.008
  • Prevalence and Characteristics of Hepatitis Delta Virus Infection in a
           Tertiary Hospital Setting in Cameroon
    • Authors: Henry N. Luma; Servais A.F.B. Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B. Nko’Ayissi, Dominique N. Noah
      Abstract: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-06-01
      DOI: 10.1016/j.jceh.2017.05.010
  • Bone Health and Impact of Tenofovir Treatment in Men with Hepatitis-B
           Related Chronic Liver Disease
    • Authors: Kattiparambil G. Sajith; Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E. Eapen, Thomas V. Paul
      Abstract: Chronic liver disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.jceh.2017.05.009
  • Long Term Outcomes of Patients with Significant Biliary Obstruction Due to
           Portal Cavernoma Cholangiopathy and Extra-Hepatic Portal Vein Obstruction
           (EHPVO) With No Shuntable Veins
    • Authors: Akash Shukla; Amit Gupte, Vedant Karvir, Prashant Dhore, Shobna Bhatia
      Abstract: The natural history of portal cavernoma cholangiopathy (PCC) in patients with significant biliary obstruction (SBO) who cannot undergo shunt surgery, is not known. We therefore, analyzed data of patients of extra-hepatic portal venous obstruction (EHPVO) with PCC.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-26
      DOI: 10.1016/j.jceh.2017.04.003
  • Echocardiographic and Electrocardiographic Predictors of Adverse Outcomes
           in Spontaneous Bacterial Peritonitis
    • Authors: Mahek Shah; Soumya Patnaik, Obiora Maludum, Shantanu Patil, Toni Anne De Venecia, Vincent M. Figueredo
      Abstract: Patients with cirrhosis who develop spontaneous bacterial peritonitis (SBP) suffer from cirrhotic cardiomyopathy which is characterized by impaired contractility in response to stress despite a relatively normal resting cardiac output. We hypothesized that electrocardiographic and echocardiographic information would help prognosticate patients developing SBP in addition to existing scoring systems.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.007
  • Simple Anthropometric Indices are Useful for Predicting Non-alcoholic
           Fatty Liver Disease [NAFLD] in Asian Indians
    • Authors: Ayaskanta Singh; Sasmita Parida, Jimmy Narayan, Preetam Nath, Pradeep K. Padhi, Girish K. Pati, Prasanta K. Parida, Chudamani Meher, Omprakash Agrawal, Shivaram P. Singh
      Abstract: With the rising prevalence of obesity and metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common liver disorder in both developed and developing nations. Several studies on NAFLD have described waist circumference, a surrogate marker of visceral fat accumulation and waist height ratio as a better screening tool for NAFLD and metabolic syndrome than body mass index (BMI). We conducted this study to assess simple abdominal obesity indices as a predictor of NAFLD and determine the appropriate cut-off levels with reference to NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.005
  • Impact of Acute Kidney Injury on Mortality of Patients Hospitalized for
           Complications of Cirrhosis
    • Authors: Anantha Nuthalapati; Nicholas Schluterman, Anuj Khanna, Deborah Greenberg, Paul J. Thuluvath
      Abstract: The mortality of hospitalized patients for complications of cirrhosis is very high. We examined the independent predictors of mortality, particularly the impact of increments in creatinine, in 339 consecutive patients (636 admissions) who were admitted for complications of cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.004
  • Cholemic or Bile Cast Nephropathy in a Child with Liver Failure
    • Authors: Vikrant Sood; Bikrant B. Lal, Suman Lata, Archana Rastogi, Seema Alam
      Abstract: Cholemic or bile cast nephropathy is an under-reported entity characterized by acute renal dysfunction in patients with hepatic insult. Limited literature is available regarding its clinical presentation, pathogenesis and prognosis. We hereby present a pediatric case who presented with acute on chronic liver failure with renal dysfunction secondary to cholemic nephropathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-24
      DOI: 10.1016/j.jceh.2017.05.006
  • Glycochenodeoxycholic Acid Does Not Increase Transforming Growth
           Factor-Beta Expression in Bile Duct Epithelial Cells or Collagen Synthesis
           in Myofibroblasts
    • Authors: Anna Wang; Dorothy Yu, Yuewen Gong, Jessie Garber, Gerald Y. Minuk
      Abstract: Primary sclerosing cholangitis (PSC) is a chronic, progressive hepatobiliary disorder characterized by extensive fibrosis and stricturing of the intra- and/or extra-hepatic bile ducts: Previous studies have documented low phosphatylcholine (PC) concentrations in PSC bile. The aim of this study was to determine whether low PC levels in bile facilitate toxic bile acid induced injury of biliary tract epithelial cells resulting in enhanced transforming growth factor-beta (TGF-β) expression and increased collagen synthesis by myofibroblasts.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.04.002
  • An Insight into Antibiotic Resistance to Bacterial Infection in Chronic
           Liver Disease
    • Authors: Mayank Jain; Joy Varghese, Tom Michael, Chandan Kumar Kedarishetty, Balajee G, Subramanian Swaminathan, Jayanthi Venkataraman
      Abstract: End stage liver disease leads to immune dysfunction which predisposes to infection. There has been a rise in antibiotic resistant infections in these patients. There is scanty data f from India or idea regarding the same.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.003
  • Results of Portosystemic Shunt Embolization in Selected Patients with
           Cirrhosis and Recurrent Hepatic Encephalopathy
    • Authors: Narendra S. Choudhary; Sanjay Saran Baijal, Sanjiv Saigal, Amit Agarwal, Neeraj Saraf, Rohit Khandelwal, Vaibhav Jain, Anubhav Harish Khandelwal, Abhay Kapoor, Deepak Jain, Smurti R. Misra, Rajesh Puri, Randhir Sud, Arvinder S. Soin
      Abstract: Large portosystemic shunts (PSSs) may lead to recurrent encephalopathy in patients with cirrhosis and embolization of these shunts may improve encephalopathy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-27
      DOI: 10.1016/j.jceh.2017.03.012
  • Thromboelastography for Assessing the Risk of Bleeding in Patients With
           Cirrhosis—Moving Closer
    • Authors: Vaibhav Somani; Deepak Amarapurkar, Apurva Shah
      Abstract: Conventional coagulation tests (CCTs) in patients with cirrhosis only assess procoagulant factors and are poor predictors of bleeding risk. In spite of this knowledge, they are routinely used prior to invasive procedures, and attempts are made to correct these abnormalities before invasive procedures. These practices are not supported by the evidence and are harmful to the patients.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-21
      DOI: 10.1016/j.jceh.2017.03.001
  • A Rare Case of Primary Sarcomatous Hepatocellular Carcinoma Without
           Previous Anticancer Therapy
    • Authors: Suvradeep Mitra; Saumya Gupta, Divya Dahiya, Uma N. Saikia
      Abstract: Primary sarcomatous hepatocellular carcinoma (PSHCC) is a rare and aggressive variety of hepatocellular carcinoma (HCC). The recent evidence suggests that anticancer therapy promotes the dedifferentiation of the carcinomatous component and is largely responsible for this aggressive variant of HCC. However, in the absence of any anticancer therapy, occurrence of PSHCC is extremely rare. Herein, we present a rare case report of a 65 year old male patient, with a hepatitis B positive status, presenting with PSHCC without any history of anticancer therapy.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-24
      DOI: 10.1016/j.jceh.2017.03.008
  • Sofosbuvir and Ribavirin for 24 Weeks Is An Effective Treatment Option for
           Recurrent Hepatitis C Infection After Living Donor Liver Transplantation
    • Authors: Anil C. Anand; Shaleen K. Agarwal, Hitendra K. Garg, Sudeep Khanna, Subhash Gupta
      First page: 165
      Abstract: Recurrent hepatitis C virus (HCV) has been a serious problem after liver transplantation (LT). We report our experience of 24-week therapy with sofosbuvir (SOF) and ribavirin (RBV) in post-LT recurrent HCV in living donor liver transplantation (LDLT) setting in South Asia.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-07-06
      DOI: 10.1016/j.jceh.2017.06.007
  • Generic Direct Acting Antivirals in Treatment of Chronic Hepatitis C
           Infection in Patients of Thalassemia Major
    • Authors: Aabha Nagral; Smita Sawant, Nishtha Nagral, Pathik Parikh, Priya Malde, Rashid Merchant
      First page: 172
      Abstract: There is no published data of treating hepatitis C in thalassemia major patients with any sofosbuvir based direct acting antivirals (DAAs). This study was performed to determine the efficacy and safety of these regimes using generic drugs in the thalassemia major population.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-09-08
      DOI: 10.1016/j.jceh.2017.08.002
  • In Situ Splitting of the Cadaver Liver for Two Adult Recipients by LDLT
    • Authors: Nilesh S. Patil; Neerav Goyal, Shishir Pareek, Mohammed Nayeem, Subhash Gupta
      First page: 179
      Abstract: To expand the donor pool, split liver transplantation is conventionally performed for one adult and one pediatric recipient. Application of this technique for two adult recipients can produce remarkable impact on the waiting list. Proper donor and recipient selection is crucial for the favorable outcome following full-right and full-left liver split. Right lobe adult to adult living donor liver transplantation (LDLT) is essentially a full right and full left split. However, LDLT techniques have not been used for full right and left split.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-23
      DOI: 10.1016/j.jceh.2017.05.001
  • Hemophagocytic Lymphohistiocytosis Masquerading as Acute Liver Failure: A
           Single Center Experience
    • Authors: Nitin Jagtap; Mithun Sharma, Gupta Rajesh, Padaki Nagaraja Rao, Sekaran Anuradha, Manu Tandan, Mohan Ramchandani, Duvvuru Nageshwar Reddy
      First page: 184
      Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening disorder of extreme inflammation and unregulated immune response which require prompt recognition and early introduction of definitive therapy. HLH can present with wide range of hepatic dysfunction ranging from mild elevation of transaminases to liver failure. This study is carried out to describe the clinical and laboratory presentation of HLH.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-15
      DOI: 10.1016/j.jceh.2017.01.119
  • Characterization of Cerebral Edema in Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Chirag K. Ahuja, Swastik Agrawal, Madhu Chopra, Naveen Kalra, Ajay Duseja, Sunil Taneja, Niranjan Khandelwal, Yogesh Chawla
      First page: 190
      Abstract: The nature of cerebral edema in acute-on-chronic liver failure (ACLF) is not well studied. We aimed to characterize cerebral edema in ACLF using magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-25
      DOI: 10.1016/j.jceh.2017.04.001
  • Brain Microstructural Correlates of Cognitive Dysfunction in Clinically
           and Biochemically Normal Hepatitis C Virus Infection
    • Authors: Ajay Kumar; Amar Deep, Rakesh K. Gupta, Virendra Atam, Samir Mohindra
      First page: 198
      Abstract: This study examined correlates of the brain's neurocognitive performance among clinically and biochemically normal adult patient with hepatitis C virus (HCV). We hypothesized that anti-HCV positive individuals would demonstrate structural brain abnormalities and neurocognitive dysfunction as well as the changes in cell component and extracellular space in the white matter regions of brain in asymptomatic HCV infection by using diffusion tensor tractrography (DTT) metrics.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-24
      DOI: 10.1016/j.jceh.2017.03.011
  • Role of Human Wharton's Jelly Derived Mesenchymal Stem Cells (WJ-MSCs) for
           Rescue of d-Galactosamine Induced Acute Liver Injury in Mice
    • Authors: Raghu Ramanathan; Secunda Rupert, Sakthivel Selvaraj, Jeswanth Satyanesan, Rosy Vennila, Surendran Rajagopal
      First page: 205
      Abstract: Mesenchymal stem cells (MSCs) are multipotent precursor cells having self-renewal ability making them a candidate for use in regenerative medicine. Acute liver injury results in sudden loss of hepatic function leading to organ failure. Liver transplantation is often required to salvage patients with acute liver failure. Due to shortage of organs, identification of alternate method is the need of the hour. In view of this, an attempt has been made to check the regenerative ability of WJ-MSCs (wharton's jelly derived MSC) in mice models for acute liver injury.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-20
      DOI: 10.1016/j.jceh.2017.03.010
  • Comparative Study of Community Acquired and Nosocomial Spontaneous
           Bacterial Peritonitis and its Variants in 150 Patients
    • Authors: Girisha Balaraju; Mallikarjun Patil, Adarsh C. Krishnamurthy, Dheeraj Karanth, Harshad Devarbhavi
      First page: 215
      Abstract: Nosocomial acquisition of spontaneous bacterial peritonitis (SBP) is debated as having a different microbial etiology and prognosis. Identification of clinical, laboratory predictors of mortality and appropriate empirical antimicrobial selection is necessary to prevent early mortality and morbidity. We aimed to find the clinical and bacteriological profile in nosocomial and community acquired SBP and its variants, and the predictors of mortality.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-03
      DOI: 10.1016/j.jceh.2017.03.005
  • Comparison of Contrast Enhanced Ultrasound With Contrast Enhanced Computed
           Tomography for the Diagnosis of Hepatocellular Carcinoma
    • Authors: Sandeep Moudgil; Naveen Kalra, Nidhi Prabhakar, Radha Krishan Dhiman, Arunanshu Behera, Yogesh Kumar Chawla, Niranjan Khandelwal
      First page: 222
      Abstract: The most common primary malignant tumor of liver is hepatocellular carcinoma (HCC). The highest risk of developing HCC is seen in patients of cirrhosis. Ultrasound is used for surveillance in these patients. This study evaluates the role of contrast enhanced ultrasound (CEUS) in the diagnosis of HCC and compares CEUS to contrast enhanced computed tomography (CECT).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-29
      DOI: 10.1016/j.jceh.2017.03.003
  • Transient Elastography (Fibroscan) in Patients with Non-cirrhotic Portal
    • Authors: Praveen Sharma; Rachit Agarwal, Shashi Dhawan, Naresh Bansal, Vikas Singla, Ashish Kumar, Anil Arora
      First page: 230
      Abstract: Non-cirrhotic portal hypertension (NCPH) is a common cause of variceal bleed in developing countries. Transient elastography (TE) using Fibroscan is a useful technique for evaluation of fibrosis in patients with liver disease. There is a paucity of studies evaluating TE in patients with Non-cirrhotic portal fibrosis (NCPF) and none in Asian population. Aim of this study was to evaluate role of TE in NCPF.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-04-04
      DOI: 10.1016/j.jceh.2017.03.002
  • Is Portal Venous Pressure Or Porto Systemic Gradient Really A Harbinger of
           Poor Outcomes After Living Donor Liver Transplantation'
    • Authors: Amol Vijay Kanetkar; Dinesh Balakrishnan, Sudhindran Sudhindran, Puneet Dhar, Unnikrishnan Gopalakrishnan, Ramachandran Menon, Othiyil Vayoth Sudheer
      First page: 235
      Abstract: Portal hyperperfusion as a cause of small for size syndrome (SFSS) after living donor liver transplantation (LDLT) remains controversial. Portal venous pressure (PVP) is often measured indirectly and may be confounded by central venous pressure (CVP).
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-02-21
      DOI: 10.1016/j.jceh.2017.01.114
  • Liver Transplantation for Acute on Chronic Liver Failure
    • Authors: Narendra S. Choudhary; Neeraj Saraf, Sanjiv Saigal, Arvinder S. Soin
      First page: 247
      Abstract: Acute-on chronic liver failure (ACLF) is defined as acute insult on previous liver disease that causes sudden worsening of liver functions.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-09-05
      DOI: 10.1016/j.jceh.2017.08.001
  • Toward a Better Definition of Acute-on-Chronic Liver Failure
    • Authors: Ajay Duseja; Shivaram P. Singh
      First page: 262
      Abstract: Acute-on-chronic liver failure (ACLF) has been defined differently in the East and West. The definitions given by Asian Pacific association for the study of liver (APASL) and American association for the study of liver (AASLD) and European association for the study of liver (EASL) working group have fundamental deficiencies and contradictions and do not encompass all patients with ACLF seen in the East and West. Although the World Gastroenterology Organisation (WGO) working party attempted to provide an improved definition but this too is not appropriate.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-25
      DOI: 10.1016/j.jceh.2017.05.002
  • Norethisterone Related Drug Induced Liver Injury: A Series of 3 Cases
    • Authors: Narendra S. Choudhary; Vijay Bodh, Shraddha Chaudhari, Neeraj Saraf, Sanjiv Saigal
      First page: 266
      Abstract: Drug induced liver injury (DILI) is uncommon and severe forms are associated with significant morbidity and mortality. Female sex hormones (estrogens and progestogens) related DILI generally occur with estrogen component. Progesterone component related DILI are infrequently reported. Norethisterone is commonly used drug in gynecologic practice to prevent excess per vaginal bleeding. We report 3 cases of Norethisterone related DILI manifesting as significant rise of transaminases. All of these patients took Norethisterone for prolonged periods and improved completely after withdrawal of drug.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-05-02
      DOI: 10.1016/j.jceh.2017.01.001
  • Autoimmune Hepatitis: Diagnostic Dilemma When It Is Disguised as Iron
           Overload Syndrome
    • Authors: Gyanendra K. Acharya; Hung-I Liao, Simona Frunza-Stefan, Ronakkumar Patel, Moe Khaing
      First page: 269
      Abstract: Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation.
      Citation: Journal of Clinical and Experimental Hepatology (2017)
      PubDate: 2017-03-28
      DOI: 10.1016/j.jceh.2017.03.006
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