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Journal Cover Journal of Clinical and Experimental Hepatology
  [SJR: 0.283]   [H-I: 7]   [3 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0973-6883
   Published by Elsevier Homepage  [3039 journals]
  • ARFI Elastography of Liver Can Predict the Presence of Clinically
           Significant Esophageal Varices
    • Authors: M.D. Nadeem Parvez; Mahesh K. Goenka, Chinmay Bera, Usha Goenka
      Abstract: Background and Aim: Presence of varices is a definite sign of portal hypertension. Periodic endoscopic screening for oesophageal varices is recommended in patients with chronic liver disease to look for the development of clinically significant varices. Non-invasive test such as Acoustic Radiation Force Impulse (ARFI) elastography can exclude the presence of clinically significant varices.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.153
      Issue No: Vol. 6 (2016)
       
  • Clinical, Serological, Histological Characteristics and Treatment Outcome
           of Autoimmune Hepatitis in Elderly Indian Population
    • Authors: Nikhil Sonthalia; Pravin Rathi, Samit Jain, Ravindra Surude, Ashok Mohite, Vinay Pawar, Suhas Udgirkar, Qais Contractor
      Abstract: Background and Aim: Autoimmune hepatitis (AIH) has been traditionally a disease of young woman. Recent epidemiological studies have shown increase in prevalence of AIH among elderly, but it has been rarely reported from India. The aim was to study the characteristics of AIH in elderly Indian population.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.154
      Issue No: Vol. 6 (2016)
       
  • To Determine the Utility of Thromboelastography in Comparison to
           Conventional Coagulation Tests in Cirrhotics Undergoing Invasive Procedure
           
    • Authors: Vaibhav Somani; Deepak Amarapurkar
      Abstract: Background and Aim: Conventional tests of coagulation in cirrhotic patients only assess procoagulant factors and are poor predictors of bleeding risk. In spite of this knowledge they are routinely used prior to invasive procedures and attempts are made to correct these abnormalities before invasive procedures. These practices are not supported by the evidence and they are also harmful to the patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.155
      Issue No: Vol. 6 (2016)
       
  • Transient Elastography (Fibroscan) Assessment in Patients with Hepatic and
           Neurological Wilson's Disease
    • Authors: Tarun Joseph; Vishnu Reddy, P.V. Girish, G. Balaji, Vishnu Raju, Mallikarjun Patil, Harshad Devarbhavi
      Abstract: Background and Aim: Non-invasive assessment of hepatic fibrosis with ultrasound based transient elastography (TE) (or Fibroscan) has been validated in a number of chronic liver disease. Studies involving Wilson disease (WD) patients are rare. Our aim was to assess TE in patients with hepatic and neurological WD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.157
      Issue No: Vol. 6 (2016)
       
  • Clinical Profile and Survival Pattern of Wilson's Disease
    • Authors: Bincy Krishnan
      Abstract: Background and Aim: Wilson's disease is an inborn error of copper metabolism leading to excessive accumulation of copper in the body which damages primarily the liver and brain. The clinical presentation of Wilson disease is variable. We analysed the clinical profile, sensitivity of various diagnostic parameters, and survival pattern of patients from a period of 2011–2016.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.156
      Issue No: Vol. 6 (2016)
       
  • Prognostic Scoring Systems and Outcome of Radiological Intervention of
           Chronic Budd-Chiari Syndrome in Children: A First Time Application
    • Authors: Sumit Singh; Moinak Sarma, Rajanikant Yadav, Sheo Kumar, Raghunandan Gangwar, Surender K. Yachha, Anshu Srivastava, Ujjal Poddar
      Abstract: Background and Aim: Prognostic scoring systems (PSI) have not been validated to identify high risk children with chronic Budd-Chiari syndrome (BCS) who undergo radiological intervention (RI). Our aim was to identify which of known PSI predict the outcomes in various subgroups of chronic BCS.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.159
      Issue No: Vol. 6 (2016)
       
  • Autoimmune Hepatitis Associated with Autoimmune Hemolytic Anemia
    • Authors: Indrajit Suresh; H.P. Nandeesh, Deepak Suvarna, D. Chandrababu, H.R. Jeevan
      Abstract: Background: Numerous autoimmune disorders are encountered frequently in patients with autoimmune hepatitis. The autoimmune process might be triggered by infectious or chemical agents in susceptible individuals.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.158
      Issue No: Vol. 6 (2016)
       
  • Dysphagia Lusoria due to Abberant Right Subclavian Artery in Twins
    • Authors: Disha Sharma; Amit Dey
      Abstract: Background: An aberrant right subclavian artery is a common embryological abnormality. Most cases are asymptomatic but may present with dysphagia, that is, dysphagia lusoria. But, dysphagia lusoria has never been reported in twins. We present to you the first case of four year old female twins with dysphagia lusoria.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.161
      Issue No: Vol. 6 (2016)
       
  • Langherhans Cell Histiocytosis with Sclerosing Cholangitis in Children: An
           Entity for Recognition
    • Authors: Nagendra Kumar; Anshu Srivastava, Surender Yachha, Ujjal Poddar
      Abstract: Background and Aim: Langerhans cell histiocytosis (LCH) is an important yet uncommon cause of sclerosing cholangitis (SC) in children. We analyzed the clinical presentation and outcome of patients with SC and LCH.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.160
      Issue No: Vol. 6 (2016)
       
  • Is Non Cirrhotic Portal Fibrosis Actually Cirrhosis in Regression' A
           Histopathological Study of the “Hepatic Repair Complex” in Indian
           Patients
    • Authors: Kavita Gaur; Shahajad Ali, Puja Sakhuja, Kaushik Majumdar, Anil Agarwal, Amarender Puri
      Abstract: Background and Aim: The precise etiopathogenesis of non-cirrhotic portal fibrosis (NCPF) remains unknown. Histologically subtle pointers seen in NCPF are reminiscent of regressed cirrhosis. The present study was undertaken to (a) examine whether histological features of fibrosis regression existed in an Indian cohort of NCPF patients; (b) correlate these features with fibrosis scores and glutamine synthetase (GS) immunopattern and (c) postulate a possible etiopathogenetic model explaining this entity.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.163
      Issue No: Vol. 6 (2016)
       
  • Thromboelastography (TEG) does not Predict Thrombophilia in Hepatic Venous
           Outflow Tract Obstruction (HVOTO)
    • Authors: Abhinav Jain; Shobna Bhatia, Akash Shukla
      Abstract: Background and Aim: TEG assesses dynamics of clot formation and is reliable for assessing coagulation state in cirrhosis. TEG has been used to assess prothrombotic states. The combination of prothrombotic state and liver dysfunction hampers interpretation of traditional coagulation tests in HVOTO. However, role of TEG in HVOTO remains uninvestigated. We performed TEG in HVOTO patients to predict prothrombotic disorder.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.162
      Issue No: Vol. 6 (2016)
       
  • Do Nonselective Beta Blockers (NSBB) Increase the Risk of Acute Kidney
           Injury (AKI) in Decompensated Cirrhosis
    • Authors: Srijith Kadavanoor; Deni Joseph, M. Ramu, Prasanth Sudheendaran, Chethan Govindaraju, Nikhil Suraj, Krishnadas Devadas
      Abstract: Background and Aim: Recent studies have shown that beta blockers increase the risk of HRS in decompensated cirrhosis especially with refractory ascites and after first episode of SBP. The debate continues with another group claiming that it is beneficial in certain group of patients with acute on chronic liver failure. Beta blockers still remain indispensable and patient selection is paramount. The aim is to study whether nonselective beta blockers (NSBB) increase the risk of AKI in decompensated cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.165
      Issue No: Vol. 6 (2016)
       
  • Esophageal Varices on Congenital Esophageal Stricture—Whom to Tackle
           First'
    • Authors: Shyam S. Sharma; Lalit Bharadia
      Abstract: Background: Esophageal stricture is a known complication after endoscopic treatment of esophageal varices. Author wants to describe a c/o congenital esophageal stricture which posed difficulty in endoscopic management of portal HT.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.164
      Issue No: Vol. 6 (2016)
       
  • Spectrum of Congenital Hepatic Fibrosis (CHF) in Infants and Children from
           a Tertiary Care Centre
    • Authors: Subhamoy Das; Suvradeep Mitra, P. Srikanth, Jagadeesh Menon, Sadhna Lal, Ashim Das, Babu R. Thapa
      Abstract: Background and Aim: Congenital hepatic fibrosis (CHF) is a rare autosomal recessive disorder responsible for portal hypertension. We retrospectively analyzed the clinical spectrum of patients seen over past 10 years.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.167
      Issue No: Vol. 6 (2016)
       
  • A Case Report on Primary Hepatic Amyloidosis
    • Authors: Rohan Reddy; Shravan Kumar, Uma Devi, Ramanna Macherla
      Abstract: Background: Hepatic amyloidosis is a rare disease that presents as an infiltrative disease involving the liver. Amyloidosis is a systemic disease characterized by extracellular deposition of amyloid protein in many organs. Progressive organ involvement leads to organ malfunction and death usually resulting from renal and/or cardiac involvement. Liver and spleen are major sites of involvement. The wide range of presenting symptoms encountered makes rapid clinical diagnosis difficult. None of the present imaging techniques is capable of specifically demonstrating the presence of amyloid.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.166
      Issue No: Vol. 6 (2016)
       
  • ADAMTS13 Deficiency Predisposes to Systemic Macro and Microvascular
           Complications in NCIPH Patients
    • Authors: Ashish Goel; G.J. Amirtharaj, Sureshkumar Sarvanan, Banumathi Ramakrishna, Anup Ramachandran, K.A. Balasubramanian, Uday Zachariah, K.G. Sajith, Ian Mackie, Elwyn Elias, C.E. Eapen
      Abstract: Background and Aim: ADAMTS13 (a disintegrin like and metalloproteinase with thrombospondin repeats), deficiency, which predisposes to increased platelet adhesion to endothelium, is seen in patients with decompensated cirrhosis and in NCIPH (non-cirrhotic intrahepatic portal hypertension) with preserved liver function. In this study, we compared systemic vascular complications in these patients, during follow up.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.169
      Issue No: Vol. 6 (2016)
       
  • Safety and Outcome of Liver Biopsy in Infants and Children
    • Authors: P. Srikanth; Uma Devi, Jagadeesh Menon, Subhamoy Das, Suvradeep Mitra, Manjinder Randhawa, Sadhna Lal, Ashim Das, Babu R. Thapa
      Abstract: Background and Aim: Histological diagnosis is the gold standard in many of the early onset liver disorders. Liver biopsy is one of the most common invasive procedures performed by a hepatologist. The safety and efficacy of the procedure are less studied in infants and children, even though it is more often performed than adult patients. We retrospectively reviewed the cases of liver diseases who had undergone percutaneous liver biopsy (LB) over last three years.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.168
      Issue No: Vol. 6 (2016)
       
  • Non-Invasive Markers: Fibrometer, Fibroscan vs Liver Biopsy in Detecting
           Liver Fibrosis in HBV Patients
    • Authors: Narayanasamy Krishnasamy; Sajeeth Prabu, Chezhian Annasamy, Senthilkumar Ramalingam, J. Janifer Jasmine, Karthick Rajendran
      Abstract: Background and Aim: Liver biopsy is needed to assess the degree of liver damage. However, its invasive nature of test, a alternative test is needed. Our aim is to detect liver fibrosis using non-invasive markers like Fibroscan, Fibrometer in patients with hepatitis B infection and also to compare non-invasive markers with invasive liver biopsy.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.170
      Issue No: Vol. 6 (2016)
       
  • Combination of TACE and Sorafenib Improves Outcomes in BCLC Stages B/C of
           Hepatocellular Carcinoma: A Single Centre Experience
    • Authors: Joy Varghese; Chandan Kumar Kedarisetty, Jayanthi Venkataraman, Vijaya Srinivasan, Thiruchunapalli Deepashree, Mangerira Chinnappa Uthappa, Kaliamurthy Ilankumaran, Sanjay Govil, Mettu Srinivas Reddy, Mohamed Rela
      Abstract: Background and Aim: Transarterial chemoembolization(TACE) or sorafenib is recommended for hepatocellular carcinoma BCLC stages B and C respectively. We studied the role of TACE+sorafenib in BCLC stages B/C.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.172
      Issue No: Vol. 6 (2016)
       
  • Characterization of a Novel Microrna Identified by Small RNA Deep
           Sequencing and its Implication in the Development of Hepatocellular
           Carcinoma
    • Authors: Suchandrima Ghosh; Joyeeta Chakraborty, Priyanka Kumari, Amit Ghosh, Alip Ghosh, Debanjali Dasgupta, Shaleen Agarwal, Subash Gupta, Simanti Datta, Abhijit Chowdhury, Raghunath Chatterjee, Soma Banerjee
      Abstract: Background and Aim: Progression of hepatocellular carcinoma (HCC) though widely studied but still lot remains to decipher the complex process by which the disease progresses. MicroRNAs are the master regulators of myriads of cellular pathways involved in cancer development and progression. Next generation sequencing is the powerful genomic tool to profile known miRNAs in a disease precisely as well as for identification of novel miRNAs. Identification of a novel miRNA having differential regulation in HCC may give an insight to its development.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.171
      Issue No: Vol. 6 (2016)
       
  • Role of Volumetric Density Mapping in Differentiating Infiltrative HCC
           from the Residual Liver and its Affect on the Treatment Planning in
           Cirrhotic Liver
    • Authors: Sonal Krishan; Vikram Singh
      Abstract: Background and Aim: Infiltrative HCC is being increasingly seen in patients with cirrhosis. Patients present often present late with portal vein tumour thrombus. However the tumour is difficult to distinguish from the surrounding hetergenous cirrhotic liver. Evaluating the precise volume and true extent of the intrahepatic disease in these patients and the viability of the thrombus if any is essential to guide any non surgical treatment planning such as TACE/TARE/EBRT. Our preliminary study investigates the feasibility of whole liver volumetric enhancement quantification to measure tumour extent evaluate treatment response.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.176
      Issue No: Vol. 6 (2016)
       
  • Not All Peri-Ductal Plaque Like Enhancement Is Cholangiocarcinoma- Primer
           For Clinicians
    • Authors: Sonal Krishan
      Abstract: Background and Aim: The early diagnosis of periductal infiltrating cholangiocarcinoma can be very difficult because this entity may begin as a benign-looking stricture. The correct diagnosis of peribiliary cholangiocarcinoma depends on differentiating the benign focal stricture from a true malignancy. The aim of this retrospective review was differentiating periductal plaque like cholangiocarcinoma from the benign stricture and identifying any discriminant CT/MR findings.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.175
      Issue No: Vol. 6 (2016)
       
  • Survival Benefit of Vitamin D Replacement on Deficient Decompensated
           Cirrhosis
    • Authors: Sharad K. Jha
      Abstract: Background and Aim: Low levels of vitamin D are associated with adverse outcome in various disorders. However role of Vitamin D deficiency in prognosis of decompensated cirrhosis has not been clearly established. The purpose of this study was to assess the levels of vitamin D in decompensated cirrhotic patients and effect of vitamin D replenishment on the mortality.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.178
      Issue No: Vol. 6 (2016)
       
  • Dual Energy CT- Surrogate Quantitative Marker of Response to Targetted
           treatment in HCC
    • Authors: Sonal Krishan; Hitesh Lukhi
      Abstract: Background and Aim: Dual energy CT (DECT)– novel CT imaging technique at two different energies, can be used to discriminate between different materials (e.g., fat, calcium, iodine, and water), which are not allowed by conventional CT. The images reconstructed from these differential data, including iodine concentration maps, may provide diagnostic information beyond that obtainable with conventional CT Aim: To evaluate the supplementary value of dual energy CT to assess response in cirrhotic patients with HCC following targeted therapy.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.177
      Issue No: Vol. 6 (2016)
       
  • Prediction of Hepatic Encephalopathy by Liver Stiffness Measurement with
           Fibroscan in Patients with Cirrhosis of Liver
    • Authors: Ahmed Lutful Moben; Mohammad Noor-E-Alam, M.A. Rahim, Faiz Ahmad Khondoker, Farjana Majid, Mamun Al Mahtab
      Abstract: Background & Aim: Hepatic encephalopathy (HE) is a very common and detrimental complication of liver cirrhosis patients. Liver stiffness measurement (LSM) is tested for prediction of hepatic encephalopathy, so that preventive measure could be taken or enhanced.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.180
      Issue No: Vol. 6 (2016)
       
  • Lactulose Tolerability and Adverse Effect Profile in Indian Patients With
           Chronic Liver Disease – A Knowledge, Attitude and Practice Study
    • Authors: Sahaj Rathi; Madhu Chopra, Sunil Taneja, Ajay Duseja, Yogesh K. Chawla, Radha K. Dhiman
      Abstract: Background & Aim: Lactulose is a cornerstone of treatment of hepatic encephalopathy (HE). However, it is often poorly tolerated, over a third of patients being non-compliant. This is one of the major reasons for its limited use for minimal HE(MHE) and primary prophylaxis of HE. Interestingly, Indian patients tolerate lactulose very well with excellent compliance. We aim to understand the perception of Indian patients towards lactulose with a Knowledge, Attitude and Practice(KAP) model.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.179
      Issue No: Vol. 6 (2016)
       
  • Prevalence of Infections in Acute Decompensation of Cirrhosis: A Tertiary
           Care Centre
    • Authors: Tarana Gupta; Dibya Lochan, Sahaj Rathi, Ajay Duseja, Sunil Taneja, Yogesh K Chawla, Radha K. Dhiman
      Abstract: Background and Aim: Infections are the most common cause of acute decompensation of cirrhosis. The present study was conducted to evaluate incidence of bacterial infections in acute decompensation of cirrhosis, pathogens involved and their impact on prognosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.182
      Issue No: Vol. 6 (2016)
       
  • Tadalafil, a Phosphodiesterase-5 Inhibitor, Improves Erectile Dysfunction
           in Patients with Liver Cirrhosis
    • Authors: Jitender Thakur; Sandeep Grover, Sahaj Rathi, Madhu Chopra, Sunil Taneja, Ajay Duseja, Yogesh Chawla, Anil Bhansali, Radha K. Dhiman
      Abstract: Background and aim: Erectile dysfunction (ED) is common in patients with liver cirrhosis. Though ED leads to a significant deterioration in the quality of life, it is often neglected by most caregivers as well as researchers. This study evaluates the prevalence of ED in patients with cirrhosis, associated factors, and response to treatment with Tadalafil, a phosphodiesterase-5 inhibitor.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.181
      Issue No: Vol. 6 (2016)
       
  • Acute on Chronic Liver Failure (ACLF)—Clinical Profile, Predictors of 1
           and 3 Months Mortality from a South Indian Tertiary Care Center
    • Authors: Santosh K. Yadav; Chethan Govindraju, Sandeep Narayanan, Arun Iyer, Shahna Fathima, Krishnadas Devdas, Srijaya Sreesh, Shanid Satthar, Prasanth
      Abstract: Background and Aim: ACLF is a new entity which is used for patients with acute complication of cirrhosis with organ failure(s). Defined differently by different associations, it lacks a consensus on clinical profile and precipitating event in different parts of world. In contrast to acute decompensation of compensated cirrhosis, ACLF has a high 1 and 3 months mortality, with hope of reversibility after successful treatment of acute insult. The aims of the study were (1) to identify clinical profile of ACLF in our population and (2) predictors of 1 and 3 month mortality.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.008
      Issue No: Vol. 6 (2016)
       
  • Clinical Profile of Patients With Acute-on-Chronic Liver Failure
    • Authors: Dinesh Singh; Mayank Gupta, Sunil Dadhich, Prabhat Ranjan, Shubham Vatsya
      Abstract: Background and Aim: Acute on chronic liver failure (ACLF) is defined as sudden deterioration of liver functions due to acute insult in patients with known or unknown chronic liver disease. Its main feature is the reversibility, and high short term mortality due to multi-organ failure (MOF). The aim of the study is to study the clinical, laboratory and etiological profile of patients with ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.007
      Issue No: Vol. 6 (2016)
       
  • Invasive Fungal Infections in Patients of Acute on Chronic Liver Failure
    • Authors: Nipun Verma; Shreya Singh, Sunil Taneja, Shiva Prakash, Arunaloke Chakarbarti, Virendra Singh, Ajay Duseja, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Background and Aim: Invasive Fungal Infections (IFI) are an emerging concern in patients of Acute on Chronic Liver Failure (ACLF). Timely and accurate diagnosis in patients is often difficult. The aim of the study is to study the impact of IFI in ACLF and assess the role of serum biomarkers for early diagnosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.006
      Issue No: Vol. 6 (2016)
       
  • Predictors of Mortality at 3 Months and 6 Months Excluding 1 Month
           Mortality in Patients with Acute on Chronic Liver Failure (ACLF)—A
           Single Centre Experience
    • Authors: Prasanth T. Sudheendran; Chethan Govindaraju, Rathan Cyriac, Nikhil Suraj, Deni Joseph, K. Srijith, Ramu Muraleedharan, Shanid Abdul, Srijaya Sreesh, Prasanth K. Sobhan, George Peter, Suthanu A. Bahuleyan, Selwyn Noronha, Krishnadas Devdas
      Abstract: Background and Aim: Acute on Chronic Liver Failure (ACLF) is a newly described clinical entity. Most of the studies assess the 28 days mortality with SOFA, MELD and CTP scores correlating with outcome. We have taken only those patients who survived the first 1 month. Our aim was to analyse the different variables and assess the predictors of mortality.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.005
      Issue No: Vol. 6 (2016)
       
  • Comparison of Acute-on-Chronic Liver Failure (ACLF): HBV Related Versus
           Non-Viral Cirrhotics in Coastal Eastern India
    • Authors: Sambit Behera; Preeatm Nath, Prasanta Parida, Pradeep Padhi, Jimmy Narayan, Girish Pati, Shivaram P. Singh
      Abstract: Background and Aim: Acute-on-Chronic Liver Failure (ACLF) is an emerging entity. There is limited data on comparative analysis of ACLF cases in HBV related versus non-viral cirrhotics. The present study was undertaken to compare HBV related versus non-viral ACLF cases in coastal eastern India.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.004
      Issue No: Vol. 6 (2016)
       
  • Study of Prevalence of Fatty Acid Oxidation Defects in Children and Adults
           With Acute Liver Failure: Significance of Carnitine/Acylcarnitine and
           Aminoacid Profile
    • Authors: Vikrant Sood; Dinesh Rawat, Rajeev Khanna, Shvetank Sharma, Prem K. Gupta, Seema Alam, Shiv K. Sarin
      Abstract: Background and Aim: Limited pediatric data suggests that fatty acid oxidation defects (FAODs) may underlie or modify the course of acute liver failure (ALF), but there is no adult data on this aspect. Significance of carnitine/acylcarnitine and aminoacid profile in patients with ALF is similarly undetermined. Thus this study was undertaken to study the prevalence of FAODs and significance of abnormalities in carnitine/acylcarnitine and aminoacid profile in ALF patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.003
      Issue No: Vol. 6 (2016)
       
  • Real Life Experience of Sofosbuvir Based Therapy for Chronic Hepatitis C
           Patients From North East India
    • Authors: K.S. Prasanna; Kamal Chetri, Mukesh Agarwala, Partha Roy, Arvind Kelkar
      Abstract: Background and Aim: Directly acting antivirals have changed the hepatitis C treatment drastically with good (>90%) sustained virologic response rates (SVR) in most patient groups in trials. We are presenting our real life experience with Sofosbuvir (SOF) based regimens in hepatitis C treatment.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.017
      Issue No: Vol. 6 (2016)
       
  • Burden of Renal Dysfunction in Hepatitis C Virus Infection: An Important
           Unmet Treatment Need in the Sofosbuvir Era
    • Authors: Amey D. Sonavane; Deepak Amarapurkar
      Abstract: Background and Aim: The downstream metabolite GS-331007 of the potent NS5B inhibitor sofosbuvir is exclusively eliminated renally (through combination of glomerular filtration and active tubular secretion). Results of phase II and III clinical trials of sofosbuvir have excluded patients with creatinine clearance (CrCl) level less than 60mL/min as its safety is not established in this population thus representing an unmet need in the treatment of Hepatitis C virus (HCV) infection. The aim of the study was to assess the prevalence, risk factors and burden of renal dysfunction in HCV patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.016
      Issue No: Vol. 6 (2016)
       
  • Liver Dysfunction in Thalassemic Children: More in Splenectomized Than
           Non-Splenectomized Cases
    • Authors: Sajan Agarwal; Sunil Gomber
      Abstract: Background and Aim: During recent year, liver disease has emerged as a major cause of mortality in patients with β thalassemia major. Multicenter cross-sectional studies have reported that the development and the severity of liver fibrosis are strongly related to the extent of liver iron overload and to the presence of chronic hepatitis infection. This study was conducted to find out the role of iron overload along with concomitant chronic viral infection as a cause of liver dysfunction in patients with β-thalassemia major.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.015
      Issue No: Vol. 6 (2016)
       
  • Role of Procalcitonin in Early Detection of Infections in Acute on Chronic
           Liver Failure in Liver Intensive Care
    • Authors: Swapnil Dhampalwar; Aamritangsu Borkakoty, Sunil Taneja, Ajay Duseja, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Background and Aim: Infection is a major cause of mortality in Acute on Chronic Liver Failure (ACLF). Conventional scoring systems have limited prognostic accuracy ACLF. These scores fail to incorporate markers of sepsis and systemic inflammation and sequential organ failures. The aim of the study is to assess the role of biomarkers of sepsis and systemic inflammation on presentation and subsequently as predictor of infection and outcome in patients with ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.013
      Issue No: Vol. 6 (2016)
       
  • Assess 28-Day Survival of Top Down Approach of Slow Low-Dose Continuous
           Albumin+Furosemide±Terlipressin (SAFI±T) and N-Acetycystine Infusion and
           Probiotics in ACLF Patients with MELD≥35, Ascites and High CVP (Central
           Venous Pressure)±Organ Failure
    • Authors: Gaurav Pande; Kamlesh Kumar, Prabhat Sharma, V.P. Krishna, Amit Goel, Abhai Verma, Samir Mohindra, Praveer Rai, Uday C. Ghoshal, Rakseh Aggrawal, Vivek A. Saraswat
      Abstract: Background and Aim: Pathophysiology of ACLF involves dysbalanced systemic inflammation and worsened hyperdynamic circulation and altered gut permeability leading to multi organ dysfunction. A combination cocktail incorporating patho-physiological changes may impact survival. The aim is to study in ACLF patients the efficacy and safety of top-down therapy administered according to a response-guided protocol to achieve complete (clinically dry) ascites mobilization and UNa>80mmol/L.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.012
      Issue No: Vol. 6 (2016)
       
  • New International Club of Ascites Definition of Acute Kidney Injury
           Applied at Admission is not Independently Associated with Mortality in
           Patients with Acute-on-Chronic Liver Failure
    • Authors: Harneet Singh; Shiran Shetty, Girisha Balaraju, Anurag Shetty, C. Ganesh Pai
      Abstract: Background and Aim: The significance of the new definition for acute kidney injury (AKI) proposed by the International Club of Ascites (ICA) for patients with chronic liver disease (CLD) has not been studied extensively in acute-on-chronic liver failure (ACLF). The aim of the study was to determine the association between the different definitions of renal dysfunction and short-term mortality in patients with ACLF.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.011
      Issue No: Vol. 6 (2016)
       
  • Acute on Chronic Liver Failure and Acute Decompensation: Do They Behave
           Same on Long Term
    • Authors: Chethan Govindaraju; Prasanth Sudheendran, Nikhil Suraj, Rathan Joseph, George Peter, Suthanu Bahuleyan, Shanid Sathar, Prasanth Sobhan, Srijaya Sreesh, Selwyn Noronha, Devadas Krishnadas
      Abstract: Background and Aims: We know acute on chronic liver failure (ACLF) has high short-term mortality compared to acute decompensation (AD) but we do not have long-term data. So our aim was to assess the mortality and factors predicting it at the end of 3 and 6 months in AD and ACLF group.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.010
      Issue No: Vol. 6 (2016)
       
  • Impact of Hepatic- and Extrahepatic-Insults on the Outcome of
           Acute-on-Chronic Liver Failure
    • Authors: Tarana Gupta; Radha K. Dhiman, Sahaj Rathi, Swastik Agrawal, Ajay Duseja, Sunil Taneja, Yogesh K. Chawla
      Abstract: Background and Aim: Acute-on-chronic liver failure (ACLF) is a clinical scenario wherein an acute insult leads to deterioration of underlying chronic liver disease. The aim of the present study to assess the differences in outcome and predictors of mortality in ACLF precipitated by hepatic- or extrahepatic-insults.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.009
      Issue No: Vol. 6 (2016)
       
  • SVR12 Among 40 Patients of Chronic Hepatitis C Treated With
           SOF/RBV+/−pegIFN-Result From a Single Tertiary Center Kolkata, West
           Bengal
    • Authors: Asokananda Konar; Jaya G. Chatterjee
      Abstract: Background and Aim: Hepatitis C is a major cause of liver related morbidity and mortality, with approximate global prevalence 122–185 million people. Better understanding of HCV lifecycle and advent of newer DAA has revolutionized its treatment and outcome. There are less available data on SVR12 response with DAA from India. The aims of the study were (1) to estimate SVR12 response in CHC; treatment-naive, treatment-experienced, cirrhotics and non-cirrhotics, (2) to compare SVR12 among cirrhotics and non-cirrhotics and (3) to assess overall adverse effects.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.027
      Issue No: Vol. 6 (2016)
       
  • Comparison of Sofosbuvir Plus Ribavirin Plus Peg-Interferon With
           Sofosbuvir and Ribavirin for Treatment of Genotype 3 Treatment Naive
           Indian Chronic Hepatitis C Patients: An Interim Analysis of Ongoing RCT
    • Authors: Ujjwal Sonika
      Abstract: Background and Aim: Sofosbuvir plus Ribavirin plus peginterferon (SRPeg) for 12 weeks and Sofosbuvir and Ribavirin (SR) for 24 weeks are the recommended treatment regimens for treatment naive genotype 3 chronic hepatitis C patients. There is sparse published data on the sustained virological response (SVR12) among Indian's with either of these 2 combinations.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.026
      Issue No: Vol. 6 (2016)
       
  • Upper Gastro Intestinal (UGI) Endoscopic Lesions in Patients with
           Hepatitis C
    • Authors: Ashish Kumar; Sanjay Goyal, Harnoor Bhardwaj, Bachan Bhardwaj, Pallav Jain
      Abstract: Background and Aim: Hepatitis C is a huge burden on health care system. This study describes different types of lesions encountered in patients with hepatitis C undergoing UGI endoscopy.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.025
      Issue No: Vol. 6 (2016)
       
  • Safety and Effectiveness of Response-Guided Therapy Using Pegylated
           Interferon and Ribavirin for Chronic Hepatitis C Virus Infection in
           Patients on Maintenance Dialysis
    • Authors: Amit Goel; Rajat Bhargava, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Amit Gupta, Raj Sharma, Praveer Rai, Rakesh Aggarwal
      Abstract: Background and Aim: Treatment of hepatitis C virus (HCV) infection in patients with end-stage renal disease (ESRD) is difficult. Addition of ribavirin to pegylated-interferon (Peg-IFN) may help to improve the treatment response. Further, treatment duration could be shortened using a response-guided treatment (RGT) approach. We aimed to assess the safety and effectiveness of RGT with Peg-IFN and ribavirin in patients of chronic hepatitis C with ESRD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.024
      Issue No: Vol. 6 (2016)
       
  • Genotype Distribution of Hepatitis C Virus in Patients With Chronic
           Hepatitis C Infection in Kashmir: A Cross Sectional Study
    • Authors: Nisar A. Shah; Shagufta Parveen, Showkat Kadla, Asif shah, Mariya Querishi, Samina Farhat, Bilal Khan, Shaheena Parveen
      Abstract: Background and Aim: Hepatitis C virus (HCV), an important cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma shows a considerable genetic heterogeneity among the patients infected with hepatitis C virus from all over the world. At least six main groups of sequence variants are recognized. The natural history of disease and response to treatment may be related to the genotype of HCV in a particular patient. Antigenic differences between genotypes also have implications for optimal design of serological sequencing and confirmatory assays for HCV.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.023
      Issue No: Vol. 6 (2016)
       
  • A Study on Prevalence of Hepatitis B Among Adult Population in South
           Kashmir
    • Authors: Showkat Kadla; Nisar A. Shah, Mudasir Bhat, Mohamad Khan, Bilal Khan, Asif Shah, Shaheena Parveen, Shaheen Nazir
      Abstract: Background and Aim: Hepatitis B virus is a small DNA virus that belongs to Hepadnaviridae family. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus. It is a major global health problem. It can cause chronic liver disease and chronic infection and puts people at high risk of death from cirrhosis of the liver and liver cancer. More than 240million people have chronic (long-term) liver infections. About 600,000 people die every year due to the acute or chronic consequences of hepatitis B.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.022
      Issue No: Vol. 6 (2016)
       
  • A Study on Clinical, Biochemical, Serological, and Histopathological
           Profile of Incidentally Detected Hepatitis B Infection
    • Authors: Showkat Kadla; Nisar A. Shah, Sakshi Sharma, Inamu Rehman, Bilal Khan, Asif Shah, Shaheena Parveen, Shaheen Nazir
      Abstract: Background and Aim: Incidentally detected Hepatitis B is a common health problem in our community and common cause for referrals to a gastroenterologist but at the same time it has not been well studied. Our aim is to study the clinical, biochemical, serological, nucleic acid (HBV DNA) and histological profile of incidentally detected HBV positive patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.021
      Issue No: Vol. 6 (2016)
       
  • Randomized Study of Interferon Based and Interferon Free Sofosbuvir
           Containing Regimens in Treatment of Patients With Hepatitis C Genotype 3
           Infection
    • Authors: Anurag Tiwari; Sunit Shukla, Ajay Nandmer, Vinod Dixit
      Abstract: Background and Aim: In India genotype 3 is most prevalent (2/3rd) of total hepatitis C burden. Sofosbuvir, a polymerase inhibitor is pangenotypic directly acting antiviral for hepatitis C. In this study we evaluate two sofosbuvir containing regimens with or without pegylated interferon (PEGIFN) in patients with hepatitis C genotype 3 infections.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.020
      Issue No: Vol. 6 (2016)
       
  • HBx Hijacks Nuclear Body Protein Sp110 and Promotes Viral Pathogenesis
    • Authors: Isha Sengupta; Chandrima Das, Dipanwita Das, Runu Chakravarty, Santanu Adhikary, Siddhartha Roy
      Abstract: Background and Aim: Hepatitis B virus (HBV) is the cause for chronic liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). HBx, a 17kDa multifunctional protein, encoded by HBV, plays a crucial role in pathogenesis and replication of HBV. HBx is known to interact with many host factors, directly or indirectly, and thereby alters their regular functioning for its own benefit. On the other hand, nuclear bodies (or PML bodies) are nuclear sub compartments that are involved in many cellular processes like transcription, DNA damage response and anti-viral response.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.019
      Issue No: Vol. 6 (2016)
       
  • Circulating Bone Marrow-Derived Stem Cells in Patients With Chronic
           Hepatitis C: Relation to Hepatic Progenitor Cells and Hepatocyte
           Proliferation
    • Authors: Hoda E. Aggan; Nahla Farahat, Basma E. Sabaa, Amany Elyamany, Rawhia A. Esa
      Abstract: Background and Aim: Bone marrow-derived stem cells (BMSCs) are pluripotent cells that can be mobilized into circulation and recruited to sites of tissue injury where they promote local repair. The present work was designed to study circulating bone marrow (BM)-derived hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) and serum stem cell factor (SCF) levels in patients with chronic hepatitis C (CHC) in relation to hepatic progenitor cells (HPCs) and hepatocyte proliferation.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.018
      Issue No: Vol. 6 (2016)
       
  • Check Point for Esophageal Variceal Bleeding Using Band Ligator –
           Outstanding Efficacy But at Low Cost'
    • Authors: Amol S. Patil; Avinash Balekuduru, Lokesh Locheruvapalli, Ravi Kiran, B.S. Satyaprakash
      Abstract: Background & Aim: Variceal band ligation (VBL) is recommended as the preferred endoscopic method for obliteration of esophageal varices.1 Multiple categories of band ligators were developed to manage variceal bleeding. The aim of the study is to assess the outcome of variceal bleed and the efficacy of low cost (Rs. 1700/–) variceal band ligator (super clik-medenta) for VBL at our center.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.045
      Issue No: Vol. 6 (2016)
       
  • Serum ALT is an Independent Predictor of Metabolic Syndrome and Insulin
           Resistance in Patients of Non-alcoholic Fatty Liver Disease
    • Authors: Preetam Nath; Prasanta Kumar Parida, Jimmy Narayan, Pradeep Kumar Padhi, Girish Kumar Pati, Ayaskanta Singh, Bijay Misra, Debasis Misra, Sanjib Kumar Kar, Manas Kumar Panigrahi, Chudamani Meher, Omprakash Agrawal, Niranjan Rout, Kaumudee Pattnaik, Pallavi Bhuyan, Manorama Swain, Shivaram Prasad Singh
      Abstract: Background & Aim: Aminotransferase assay is often used as a screening test as well as an endpoint for resolution of disease in NAFLD. The aim of the study was to evaluate the relationship of transaminase level with metabolic variables and histology in NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.044
      Issue No: Vol. 6 (2016)
       
  • A Study of Prevalence of Diabetes and Prediabetes in Patients with Non
           Alcoholic Fatty Liver Disease and Impact of Diabetes on Liver Histology
    • Authors: Aastha Bansal; Sudhir Mourya, Abhyudaya Verma, Bushra Khanam, Rishu Bansal
      Abstract: Background and Aim: NAFLD is one of the most common chronic liver diseases with increasing prevalence. There are limited studies on study of anthropometric, metabolic and histological parameters of NAFLD patients. This study aims to determine the clinical and metabolic profile of NAFLD patients and compare the liver histology of diabetic NAFLD patients with non diabetic NAFLD patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.043
      Issue No: Vol. 6 (2016)
       
  • Relationship of Severity of Hepatitis A With Genetic Polymorphisms in
           Hepatitis A Virus Cellular Receptor 1 (HAVCR1) Gene
    • Authors: Mercilena Benjamin; Shikha Agnihotry, Anshu Srivastava, Maya Peethambaran, Rishi Bolia, Abraham Koshy, Tony Grace, Philip Augustine, S.K. Yachha, Rakesh Aggarwal
      Abstract: Background and Aim: HAVCR1 protein is the cellular receptor for the hepatitis A virus (HAV). Genetic polymorphism in this gene may alter the outcome of HAV infection. A 6-amino acid insertion (157insMTTTVP) in it has been shown to be associated with more severe disease.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.041
      Issue No: Vol. 6 (2016)
       
  • Dual Treatment With Sofosbuvir Plus Ribavirin is as Effective as Triple
           Therapy With Pegylated Interferon Plus Sofosbuvir Plus Ribavirin in
           Predominant Genotype 3 Patients With Chronic Hepatitis C
    • Authors: Sandeep Satsangi; Manu Mehta, Ajay Duseja, Sunil Taneja, Radha K. Dhiman, Yogesh Chawla
      Abstract: Background and Aim: Sofosbuvir (SOF) was the first directly acting antiviral (DAA) made available for chronic hepatitis C (CHC) in India. We describe our ‘real life’ experience of using SOF with ribavirin (RBV) with or without pegylated interferon (PegIFN) in predominant genotype 3 patients with CHC.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.040
      Issue No: Vol. 6 (2016)
       
  • Viral Burden of HBsAg Among South Indians in a Tertiary Care
           Center—10 Year Survey
    • Authors: Narayanasamy Krishnasamy; J. Janifer Jasmine, Karthick Rajendran
      Abstract: Background and Aim: To evaluate the viral burden of HBsAg among South Indians in a tertiary care center. To estimate clinical correlation with HBV and predictor marker of a HBV seropositive patients and to know the role of family seropositivity.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.039
      Issue No: Vol. 6 (2016)
       
  • COOMBS: Continuous Overview of Mega Blood Donation of South India—A Five
           Year Study of Blood Borne Infectious Diseases
    • Authors: Narayanasamy Krishnasamy; Chezhian Annasamy, Senthilkumar Ramalingam, Shifa Babu, K. Premkumar, Karthick Rajendran, J. Janifer Jasmine
      Abstract: Background and Aim: Blood Borne Infectious Diseases (BBID) is any infection that is potential for transmissible from individual to individual through parenteral administration of blood or blood products. The level of BBID varies from country to country depending on BBID's prevalence in that particular population. Our study aim was to estimate the seroprevalence of BBID among the South Indian blood donors.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.038
      Issue No: Vol. 6 (2016)
       
  • DAAs in Genotypes 2 and 3 of Chronic Hepatitis C—A Real World
           Experience
    • Authors: Bubun Patel; Sukanya Bhrugu, Raghavendra Yarlagadda, Nayana Joshi, Rohit Maidur, Gaurav Ratnaparkhi, Ajit Kumar
      Abstract: Background and Aim: Direct acting antivirals have revolutionised treatment of Hepatitis C with Hepatitis C now being considered curable. However management of genotype 3 remains challenging.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.037
      Issue No: Vol. 6 (2016)
       
  • DAAs in Genotypes 1 and 4 of Chronic Hepatitis C—A Real World
           Experience
    • Authors: Sukanya Brugu; Bubun Patel, Nayana Joshi, Raghavendra Yarlagadda, Rohit Maidur, Gaurav Ratnaparkhi, Ajit Kumar
      Abstract: Background and Aim: HCV infection is a major cause of liver disease throughout the world with global prevalence of 3%. In India, Hepatitis C prevalence is 1% and genotypes 1 and 3 are the common genotypes.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.036
      Issue No: Vol. 6 (2016)
       
  • Oncogenic Potential of Hepatitis B Virus Subgenotype D1 Surpasses D3:
           Significance in the Development of Hepatocellular Carcinoma
    • Authors: Debanjali Dasgupta; Somenath Datta, Alok Manna, Simanti Datta, Kausik Das, Mitali Chatterjee, Gopal Krishna Dhali, Abhijit Chowdhury, Soma Banerjee
      Abstract: Background and Aim: Influence of HBV genotypes/subgenotypes on clinical outcome of liver diseases has been documented from epidemiological studies but the underlying mechanism is not well defined. Thus, the present study aims to investigate the impact of two major circulating subgenotypes of HBV in Eastern India, HBV/D1 and HBV/D3 on the disease progression to hepatocellular carcinoma (HCC).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.035
      Issue No: Vol. 6 (2016)
       
  • Hepatitis C Virus Infection in Patients on Hemodialysis in Tertiary Care
           Hospital
    • Authors: Mudumala I. Abhilash; P. Shravan Kumar, M. Uma Devi, Ramanna Macherla
      Abstract: Background and Aim: Hepatitis C virus is a major problem with an estimated global prevalence of 3%. The prevalence of HCV infection among dialysis patients is generally much higher than healthy blood donors and general population. Studies held in dialysis centers from different countries revealed that prevalence ranges from 1 to 84.6%. There is particular concern because it causes significant morbidity and mortality among hemodialysis (HD) patients. The aim of the study was to study the prevalence of HCV infection and its genotype in HD patients, HCV viremia by PCR, demographic profile and risk factors of HCV infection.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.034
      Issue No: Vol. 6 (2016)
       
  • Identification of a Microrna That Impedes Hepatitis C Virus Infection and
           Replication by Silencing Multiple Host Genes
    • Authors: Suchandrima Ghosh; Simanti Datta, Abhijit Chowdhury, Gopal Dhali, Soma Banerjee
      Abstract: Background and Aim: In general, the therapeutic approaches of chronic hepatitis C (CHC) aim at the development of compounds targeting the virus and/or host cell factors. But the monotherapy and genotype specificity often leads to drug resistance and difficulties in the treatment. As the processes of viral entry are the potential drug targets, targeting host proteins would be a good option. Thus identification of a novel small molecule which efficiently prevents viral entry into hepatocytes and its replication is urgently needed for proper management of HCV patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.033
      Issue No: Vol. 6 (2016)
       
  • Sofosbuvir Based Therapy is Useless in HCV Patients with CTP B and C Class
           of Cirrhosis With no Transplant Option
    • Authors: Ajay Kumar; Amar Deep
      Abstract: Background and Aim: Hepatitis C virus (HCV) is one of the leading causes of liver cirrhosis. Since the early 1990s, when interferon was first introduced for the treatment of HCV infection, the therapeutic goal has been viral suppression in chronic HCV viral eradication. With the introduction of new antiviral regimens with 12 week course of a NS5A and NS5B polymerase inhibitor, we are able to achieve SVR rate of more than 95%. NS5B inhibitor combination are also highly effective for previously difficult to treat and or difficult to cure HCV subgroups including patients with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.032
      Issue No: Vol. 6 (2016)
       
  • Knowledge and Attitude Regarding Care of Hepatitis B Virus (HBV) Positive
           Patients Amongst the Nurses of Tertiary Care Centre
    • Authors: Sukhpal Kaur; Radha K. Dhiman, Sandeep Satsangi, Ajay Duseja, Pankaj Arora
      Abstract: Background and Aim: Owing to the nature of work, nurses are at high risk of acquiring and transmitting the blood borne infections. Hepatitis B is one of the most significant occupational infectious risks amongst nurses. They need to be aware regarding the prevention and spread of HBV infection. The current study aims to assess the knowledge and attitude regarding hepatitis B amongst nurses.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.030
      Issue No: Vol. 6 (2016)
       
  • Sofosbuvir and Ribavirin Combination is Safe and Effective in Renal
           Transplant Recipients with HCV Infection
    • Authors: Sunil Taneja; Ajay Duseja, Arka De, Vivek Kumar, Raja Ramachandran, Ashish Sharma, Radha K. Dhiman, Krishan Gupta, Mukut Minz, Yogesh K. Chawla
      Abstract: Background and Aim: Current DAAs have revolutionized the treatment of HCV. There is no substantial data addressing the safety and efficacy of the newer antivirals in renal transplant recipients. The combination antiviral therapy using Sofosbuvir and Ribavirin is an approved treatment option for chronic HCV infection. However, the safety and efficacy of this regimen in renal transplant recipients with HCV infection is unknown. Thus, we aimed to study the safety, efficacy and SVR rates with Sofosbuvir and Ribavirin for treatment of HCV infection in renal transplant recipients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.029
      Issue No: Vol. 6 (2016)
       
  • Sero Prevalence of Acute Hepatitis Caused by HAV and HEV in Gazipur,
           Bangladesh
    • Authors: Mohammad S. Haque; Sharmin Sultana, Mamun A. Mahtab
      Abstract: Background and Aim: Hepatitis A and E virus (HAV and HEV) are the most common causes of acute hepatitis. Both of them are endemic in South Asia; specially in the developing countries, like Bangladesh. This study was undertaken to determine the prevalence, age-specific prevalence and seasonal variation of Hepatitis A and Hepatitis E in Gazipur district.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.028
      Issue No: Vol. 6 (2016)
       
  • Correlation of BMI with Subcutaneous Fat and Total Body Fat in Patients
           with NAFLD in South India
    • Authors: Guruprasad Padsalgi; Mathews Chooracken, Roy Mukkada, Antony Chettupuzha, Jose Francis, Philip Augustine, Abraham Koshy
      Abstract: Background & Aim: Nonalcoholic fatty liver disease (NAFLD) is increasing at alarming rates in south Indian population, the correlation of BMI with skin fold thickness and total body fat in patients with NAFLD has less literature, we want to see how significantly they correlate. Aims: Correlation of BMI with subcutaneous fat and total body fat in patients with NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.055
      Issue No: Vol. 6 (2016)
       
  • Socioeconomic Impact of Alcohol in Patients with Alcoholic Liver Disease
           [ALD] in Odisha
    • Authors: Shivaram P. Singh; Pradeep Padhi, Jimmy Narayan, Preetam Nath, Ayaskanta Singh, Girish Pati, Prasanta Parida, Sunil Mishra
      Abstract: Background & Aim: There is scarce information on the socio-economic impact of alcohol use in ALD patients and their families. The study was conducted to estimate the socioeconomic impact of alcohol use on patients with ALD and their families in Odisha.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.054
      Issue No: Vol. 6 (2016)
       
  • Predictors of 90 Day Mortality in Severe Alcoholic Hepatitis: Experience
           with 85 Patients at a Tertiary Care Center
    • Authors: Ravi Daswani; Ashish Kumar, Shrihari Anikhindi, Praveen Sharma, Naresh Bansal, Vikas Singla, Anil Arora
      Abstract: Background & Aim: Severe alcoholic hepatitis (SAH) is a dreaded illness with high mortality. There are only few studies which have evaluated and compared the various severity indices in SAH especially in Indian population. We analysed patients with SAH admitted to our Institute and compared various biochemical and severity indices in predicting 90 day mortality.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.053
      Issue No: Vol. 6 (2016)
       
  • Effect of GCSF on Mortality and Complications Viz. Sepsis, Encephalopathy,
           HRS and GI Bleed in Severe Alcoholic Hepatitis – A Randomized Controlled
           Study
    • Authors: Ankur Setia; Ramesh Rai
      Abstract: Background & Aim: Severe alcoholic hepatitis has very high short term mortality. Compared to standard medical therapy (SMT), GCSF improves clinical and biochemical profiles, morbidity and mortality in these patients. We evaluated efficacy of GCSF in modulating the disease course of severe alcoholic hepatitis over a period of 3 months in terms of mortality, morbidity by CTP, MELD, and mDF scores and various complications viz. sepsis, GI bleed, encephalopathy, hepatorenal syndrome in comparison to SMT.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.052
      Issue No: Vol. 6 (2016)
       
  • microRNA-124 Ameliorates Alcohol Induced Liver Injury by Restricting
           Multiple Components Involved in Intracellular Crosstalk
    • Authors: Debanjali Dasgupta; Alak Manna, Somenath Datta, Alip Ghosh, Amit Ghosh, Mitali Chatterjee, Simanti Datta, Gopal Dhali, Abhijit Chowdhury, Soma Banerjee
      Abstract: Background & Aim: Alcohol induced liver injury involves a complex array of derangements of intracellular crosstalk among liver residing parenchymal, nonparenchymal and immune cells through myriad of signaling molecules. Chronic ethanol intake renders liver macrophages, Kupffer cells (KCs) hyper-responsive to endotoxin resulting production of inflammatory cytokines via TLR4 dependent pathway leading to apoptotic death of hepatocytes and consecutive inflammation. In this study the role of microRNA-124, which polarizes macrophages towards M2 phenotype, in alcohol induced inflammation has been investigated.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.051
      Issue No: Vol. 6 (2016)
       
  • Can Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease
           Co-exist'
    • Authors: Manu Mehta; Sandeep Satsangi, Ajay Duseja, Sunil Taneja, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Background & Aim: Nonalcoholic fatty liver disease (NAFLD) by definition would require exclusion of significant alcohol intake. Present study was aimed to assess the prevalence of various components of metabolic syndrome (MS) in patients with alcoholic cirrhosis (AC) and to study the affect of its presence on the severity of liver disease, testing the hypothesis if alcoholic liver disease (ALD) and NAFLD could co-exist.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.050
      Issue No: Vol. 6 (2016)
       
  • Validation Study to Predict Mortality in Alcoholic Hepatitis: Magic Score
           Versus Other Scoring Systems
    • Authors: Arun Iyer; Chethan Govindaraju, Shanid Sathar, Sreejaya Sreesh, Krishnadas Devadas
      Abstract: Background & Aim: Alcoholic hepatitis (AH) is associated with high mortality. This study aimed at assessing the short term (up to 30 days) and 90 day mortality of severe alcoholic hepatitis and to compare various prognostic scoring systems viz Model For AH To Grade The Severity In An Asian Patient Cohort (MAGIC) versus Maddrey's Discriminant Function (mDF), age, bilirubin, international normalized ratio and creatinine (ABIC) score, Glasgow alcoholic hepatitis score (GAHS), model of end-stage liver disease (MELD) on a cohort of patients in our hospital.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.049
      Issue No: Vol. 6 (2016)
       
  • Association of NAFLD with Carotid Atherosclerosis and Serum Uric Acid
           Level
    • Authors: Masi-ur rehman Ajmal; Syed N. Afzal, Nasar Abdali, Ibne Ahmad
      Abstract: Background & Aim: NAFLD shares many features of metabolic syndrome, a highly atherogenic condition and its presence could signify a substantial cardiovascular risk. High serum uric acid levels play a role in development of NAFLD. The aim of the study: (1) To assess the association of NAFLD with carotid atherosclerosis and serum uric acid levels. (2) To assess association of various metabolic and lab parameters of metabolic syndrome with NAFLD. (3) To assess how severity of NAFLD is related to above mentioned parameters.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.048
      Issue No: Vol. 6 (2016)
       
  • Effect of Lifestyle Modification on Liver Enzyme and Fibroscan Score in
           Indian Patients with Non-alcoholic Fatty Liver Disease
    • Authors: Jayanta Paul; Raj Venugopal, Lorance Peter, K.N.K. Shetty, Mohit Shetti
      Abstract: Background & Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the hepatic manifestations of metabolic syndrome and a major burden to both the morbidity and mortality of the nation. NAFLD is remarkably increasing in developing countries like India, parallel to the increasing incidence of obesity. Lifestyle modification is a recommended treatment for NAFLD. But in most of the previous studies, improvement after lifestyle modification was assessed by liver fibrosis through liver biopsy. Liver fibrosis can also be assessed by fibroscan invasively in NAFLD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.047
      Issue No: Vol. 6 (2016)
       
  • Limited Implication of Serum Cholesterol for Diagnosing NASH
    • Authors: Sheikh Mohammad Noor-E-Alam; Ahmed Lutful Moben, Md. Zia Hyder Basunia, Amalendu Bhattacharyya, Md. Abdur Rahim, Syed Abul Foez, Faiz Ahmad Khondaker, Md. Jahangir Alam Sarker, Mohammad Forhad Abedin, Utpal Das Gupta, Md. Farhadul Islam Chowdhury, Mamun A. Mahtab
      Abstract: Background & Aim: Nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver disease presenting with abnormal lipid profiles. NAFLD ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, end stage liver disease and hepatocellular carcinoma. The aim of the study is to evaluate fasting serum cholesterol (total) level for diagnosing NASH.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.046
      Issue No: Vol. 6 (2016)
       
  • Retrospective Analysis of Post Transplant Liver Biopsies – From
           Diagnosis to Therapy – Can We Guide Further' Experience From a
           Tertiary Care Center in India
    • Authors: Nalini Bansal; Vivek Vij, Mukul Rastogi, Manav Wadhawan, Ajay Kumar
      Abstract: Background & Aim: Post transplant liver biopsies form a critical part of management of complications arising post transplant. The objective of this study was to analyze the Indian experience in pathologic diagnosis of liver biopsies after orthotopic liver transplantation (OLTx) cases with special emphasis on cases presenting with intrahepatic cholestasis IHC. Type, incidence and timing of major complications were analyzed All cases with IHC were retrospectively analyzed with clinical inputs for to look for cryptic clues in sub classifying such cases.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.067
      Issue No: Vol. 6 (2016)
       
  • Adult Liver Transplantation – Initial Experience From a Tertiary
           Care Centre at North Kerala
    • Authors: Rajneesh Rajan; Anish Kumar, K. Biju, Tony Jose, Sujith Janardhanan, Tajimal Rabia, G. Ramakrishnan, Rakesh Babu, Kishore Kanianchalil, Seethalekshmy Natarajan, Rohit Ravindran, Rajesh Nambiar, Sajeesh Sahadevan
      Abstract: Background & Aim: This study retrospectively analyses the initial experience of liver transplantation (LT) from a tertiary care centre. We are presenting data from our centre which started off with combined LDLT and DDLT programme. Its important for each transplant centre to analyze the success rate of their transplant programme and ours is one centre which started both LDLT and DDLT programme together. The aim of the study was to assess the success rate, intraoperative blood transfusion and hemodialysis requirement, postoperative infectious, vascular and biliary complications and mortality related to Live and deceased donor transplantation.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.066
      Issue No: Vol. 6 (2016)
       
  • To Evaluate Significance of Alpha Smooth Muscle Actin (ASMA) Expression on
           Liver Biopsy as Predictor of Future Graft Fibrosis in Pediatric Liver
           Transplant (LT) Recipients
    • Abstract: Background & Aim: Activated hepatic stellate cells express cytoplasmic alpha-smooth muscle actin (ASMA) prior to secreting collagen and consequent liver fibrosis. We hypothesized that quantifying ASMA could predict severity of future fibrosis after liver transplantation (LT).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.065
      Issue No: Vol. 6 (2016)
       
  • Progressive Fibrosis is Driven by Genetic Predisposition, Allo-Immunity,
           and Inflammation in Pediatric Liver Transplant Recipients
    • Authors: Sharat Varma; Jerome Ambroise, Mina Komuta, Dominique Latinne, Pamela Baldin, Raymond Reding, Francoise Smets, Xavier Stephenne, Etienne Sokal
      Abstract: Background & Aim: Protocol biopsies (PB) from stable liver transplant (LT) recipient children frequently exhibit idiopathic fibrosis. The relation between allograft inflammation, humoral immune response and fibrosis is uncertain. Also the role of HLA-DRB1 genotype has not been evaluated though it's associated with fibrosis in autoimmune hepatitis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.064
      Issue No: Vol. 6 (2016)
       
  • Effect of Pre-Transplant Malnutrition on Outcomes of Liver Transplantation
    • Authors: Neha Bakshi; Kalyani Singh, Arvinder S. Soin
      Abstract: Background & Aim: Malnutrition is universally prevalent in ESLD (End Stage Liver Disease) patients undergoing Liver Transplantation (LT) and is associated to various clinical factors. The present study focuses on the effect of pre-Transplant nutrition status on various outcomes of LT.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.063
      Issue No: Vol. 6 (2016)
       
  • Outcomes of Percutaneous Biliary Interventions in Bilioenteric Strictures
           After Living Donor Liver Transplant in Paediatric Patient Population
    • Authors: Abhay K. Kapoor; Neelam Mohan, Anubhav Khandelwal, Sanjay Baijal
      Abstract: Background and Aim: Biliary complications (BC) in paediatric population after living donor liver transplantation (LDLT) are responsible for significant morbidity and can lead to graft rejection. The overall BC incidence in transplanted children varies from 15% to 40% of which 2% to 35% are anastomotic strictures (AS). As majority of the biliary reconstruction in children is a bilioenteric (BE) anastomosis performed by a Roux-en-Y, the AS have to be managed by percutaneous transhepatic biliary drainage (PTBD).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.062
      Issue No: Vol. 6 (2016)
       
  • Nocardia Liver Abscess – An Uncommon Infection Post Liver Transplant
    • Authors: Pavan Hanchanale; Mayank Jain, Joy Varghese, Venkataraman Jayanthi, Mohamed Rela
      Abstract: Background: Nocardiosis is a rare, localised or disseminated, bacterial infection caused by aerobic actinomyces. It commonly affects immunocompromised hosts. With increasing load of post transplant patients the world over, this infection has been reported with increasing frequency.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.061
      Issue No: Vol. 6 (2016)
       
  • Renal Dysfunction in Patients with Nonalcoholic Fatty Liver Disease is
           Related to the Presence of Diabetes Mellitus and Severity of Liver Disease
           
    • Authors: Ram V. Nampoothiri; Ajay Duseja, Manish Rathi, Swastik Agrawal, Naresh Sachdeva, Manu Mehta, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Background & Aim: There is sparse data on the prevalence of renal dysfunction in patients with nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the presence of renal dysfunction in patients with NAFLD and correlate it with the severity of liver disease.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.058
      Issue No: Vol. 6 (2016)
       
  • Correlation of Insulin Resistance with Liver Histology in Obese Patients
           with NASH and in Lean NASH
    • Authors: Mathew Vadukoot L; Rajesh Gopalakrishna, Malini Eapen, Harikumar R. Nair, Ismail Siyad, Shine Sadasiv, Rama P. Venu
      Abstract: Background & Aim: Insulin resistance (IR) plays a central role in the pathogenesis of non-alcoholic steatohepatitis (NASH), especially in obese patients with diabetes and related components of metabolic syndrome (MS). The aim of the study was to correlate histopathological grading and insulin resistance in obese patients with NASH as compared to lean NASH.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.057
      Issue No: Vol. 6 (2016)
       
  • Cytokeratin 18 Fragment Level is a Useful Biomarker in Predicting
           Steatosis and NASH But Not Fibrosis
    • Authors: Sanchit Budhiraja; Ashok Jain, Vinod Dixit, Sunit Shukla, Pankaj Asati, Manish Tripathi
      Abstract: Background & Aim: Non alcoholic fatty liver disease (NAFLD) is a spectrum of liver disease (from steatosis to cirrhosis). Differentiating various stages is important for therapeutic decision making. The gold standard for the diagnosis and staging of NAFLD is liver biopsy. Cytokeratin 18 fragment (CK18-F) levels are a marker of hepatocyte apoptosis. This study was done to evaluate the role of serum CK18-F levels in predicting steatosis, significant NASH and fibrosis when compared to the gold standard i.e.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.056
      Issue No: Vol. 6 (2016)
       
  • The Pattern of Treatment Response and Its Predictors in Cirrhotic Patients
           With Overt Hepatic Encephalopathy (HE)
    • Authors: Shah A. Shemin; Thazhathu M. Ramachandran
      Abstract: Background and Aim: HE is a common debilitating complication of cirrhosis liver which can be due to a precipitating event or progressive deterioration of hepatic functional reserve. The aims of the study were: (1) To assess the pattern of treatment response to overt HE in cirrhotic patients. (2) To identify the factors influencing treatment response.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.078
      Issue No: Vol. 6 (2016)
       
  • Liver, Heart and Kidney—The Triology
    • Authors: Kayal V. Nagarajan; Ramakrishna Venugopalan
      Abstract: Background and Aim: Cirrhotic cardiomyopathy (CCM) is a sub-clinical cardiac complication. The basic pathophysiology is related to hyperdynamic circulation, splanchnic vasoconstriction and the resultant neurohormonal response. There is a probable association between CCM and hepato-renal syndrome (HRS) in view of the common pathophysiology. The aim of this study aims to assess the prevalence of CCM and correlate with severity of liver disease and etiology of cirrhosis. Also, assess the significance of the association between CCM and HRS.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.077
      Issue No: Vol. 6 (2016)
       
  • Factors Associated With in Hospital Mortality in Patients With
           Decompensated CLD
    • Authors: Ponni Gopalakrishnan; Shahna S. Fathima, Krishnadas Devadas, Gopu R. Babu, B.K. Bincy, S. Srijaya, A. Shanid, K.S. Prasanth
      Abstract: Background and Aim: The course of cirrhosis is extremely variable from patient to patient. It may be due to several factors, like hepatic synthetic function, the cause of cirrhosis, and the occurrence of liver malignancy. Establishing prognosis in a given patient with cirrhosis remains a challenging issue. The aim of the study was to assess the clinical and biochemical factors associated with in hospital mortality in patients with decompensated CLD of different etiology.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.076
      Issue No: Vol. 6 (2016)
       
  • Efficacy of Talc Pleurodesis for the Management of Refractory Hepatic
           Hydrothorax in Patients With Liver Cirrhosis
    • Authors: Ashmeet Chaudhary; Onkar Patel
      Abstract: Background and Aim: Hepatic hydrothorax in patients with decompensated liver cirrhosis is a challenging complication. Chemical pleurodesis is an effective treatment for malignant effusion and pneumothorax. Although this mode of therapy is less widely accepted in treatment of patients with hepatic hydrothorax. The need of palliative treatment in such patients encouraged us to do this work as most of our patient still are not willing for liver transplant.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.075
      Issue No: Vol. 6 (2016)
       
  • MELD vs MELD Na for Predicting Inhospital Mortality in Decompensated CLD
    • Authors: Shahna S. Fathima; Ponni Gopalakrishnan, Krishnadas Devadas, S. Srijaya, K.S. Prasanth, A. Shanid, Gopu R. Babu, Arun Iyer, Santosh K. Yadav, B.K. Bincy, George Peter
      Abstract: Background and Aim: MELD as prognostic score has several strengths compared with Child score. The variables in MELD score are simple and more objective. The incorporation of Na to the MELD (MELD-Na) has been shown to improve its predictive accuracy in earlier studies. Aim of this study is to compare meld and meld Na as predictors of inhospital mortality
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.074
      Issue No: Vol. 6 (2016)
       
  • Therapeutic Plasma Exchange (TPE) as an Adjuvant to Supportive Management
           in End Stage Liver Disease Patients With High Meld (score >25) Awaiting
           Liver Transplantation
    • Authors: Joy Varghese; Deepti Sachan, V. Jayanthi, Vijaya Srinivasan, K. Ilankumar, Kavya Harika, Mayank Jain, M. Srinivas, G.M.M. Reddy, Mohamed Rela
      Abstract: Background and Aim: Patients with high MELD score (>25) who are listed for liver transplantation, seek admission for jaundice, encephalopathy, coagulopathy, or multisystem organ dysfunction and mortality rates are high without liver transplantation. Hence our aim of the study was to determine the role of therapeutic plasma exchange (TPE) in ESLD patients with high MELD (≥25) awaiting liver transplant.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.073
      Issue No: Vol. 6 (2016)
       
  • Endothelial Injury and Oxidative Stress in Patients With Hepatitis C
           Virus-Related Cirrhosis: Relation to Renal Function and Hemodynamics
    • Authors: Hayam E. Aggan; Magdy Rashwan, Safaa Abodeya, Sabah Mahmoud
      Abstract: Background and Aim: Endothelial injury plays an important role in the pathogenesis of chronic renal diseases and may be related to oxidative stress. The present work was designed to study markers of endothelial injury and oxidative stress in patients with hepatitis C virus (HCV)-related cirrhosis in relation to renal function and hemodynamics.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.072
      Issue No: Vol. 6 (2016)
       
  • Diabetes Mellitus Increases the Severity of First Episode of Overt Hepatic
           Encephalopathy in Decompensated Cirrhosis
    • Authors: Srijith Kadavanoor; Nikhil Suraj, M. Ramu, Deni Joseph, G. Chethan, T.S. Prasanth, D. Krishnadas
      Abstract: Background and Aim: Diabetes mellitus is associated with a state of increased inflammation as a result of increased bacterial translocation due to reduced intestinal transit time and SIBO. Diabetes mellitus may alter the course of hepatic encephalopathy (HE) in decompensated cirrhosis. With the increase in cases of NASH related cirrhosis it has become important to study the relation of diabetes with respect to HE as it is one of the main complication in decompensated cirrhosis which affects quality of life.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.071
      Issue No: Vol. 6 (2016)
       
  • Relapse of Minimal Hepatic Encephalopathy in Cirrhotics After Short-Term
           Treatment—A Prospective Trial
    • Authors: Omesh Goyal; Sandeep Sidhu, Harsh Kashyap
      Abstract: Background and Aim: Minimal hepatic encephalopathy (MHE) has been shown to reverse after short-term treatment with ammonia lowering therapies. However, relapse rate of MHE after stopping treatment has not been studied so far. We aimed to evaluate long-term (9 months) efficacy of a short-term (3 months) treatment of MHE with lactulose/rifaximin, for maintenance of remission from MHE.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.070
      Issue No: Vol. 6 (2016)
       
  • Modified ‘Barrel Only’ Technique for Endoscopic Variceal Ligation
           (EVL): A Comparative Study
    • Authors: Ashish Kumar; Sanjay Goyal
      Abstract: Background and Aim: EVL is an established procedure in managing variceal bleeding. In standard technique, ligator handle is attached over the biopsy channel and catheter is passed through its opening. Catheter is retrieved from the tip of endoscope and trigger cord is attached to it. Catheter along with trigger cord is withdrawn from opening of control handle. Trigger cord is placed in a slot in the control handle. The cord is pulled in the slot till the knot is seated into it. The handle is rotated till and cord is taut.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.069
      Issue No: Vol. 6 (2016)
       
  • Late Presentation of Autoimmune Hepatitis as Decompensation in a Diagnosed
           Case of Celiac Disease Associated Ataxia Telengectasia
    • Authors: Sajan Agarwal; Umesh R. Gupta
      Abstract: Background: Celiac disease (CD) is frequently accompanied by a variety of extradigestive manifestations, thus making it a systemic disease rather than a disease limited to the gastrointestinal tract. The hepatic dysfunction presenting in CD ranges from asymptomatic liver enzyme elevations or nonspecific reactive hepatitis (cryptogenic liver disorders), to autoimmune hepatitis (AIH) related chronic liver disease (CLD). AIH are less common and are associated in the majority of cases with clinical signs and symptoms of chronic liver disease, which need specific immunosuppressive therapy, rather than just GFD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.068
      Issue No: Vol. 6 (2016)
       
  • A Study of Renal Function, Serum Sodium and Their Impact on Survival of
           Patients With End Stage Liver Disease
    • Authors: Sravan K. Korrapati; Ravi K. Allu, R.S. Girinadh Lekkala, Murali K. Palakurthy
      Abstract: Background and Aim: Serum creatinine is considered to reflect renal function; however, it is not a very accurate gauge, especially in detecting early loss of renal function. To estimate the role of serum creatinine, sodium, and estimated glomerular filtration rate (eGFR) as determinants of survival in patients with end stage liver disease (CTP-C).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.087
      Issue No: Vol. 6 (2016)
       
  • Prevalence of Driving Skill Impairment Due to Minimal Hepatic
           Encephalopathy (MHE) in Cirrhosis of the Liver
    • Authors: Adarsh Rajendran; Varghese Thomas
      Abstract: Background and Aim: Minimal hepatic encephalopathy (MHE) is present in more than half of patients with cirrhosis. MHE increases the risk of development of overt hepatic encephalopathy. MHE also causes impaired attention and precision jobs like driving skills and have a higher risk of motor vehicle crashes. The aim of the study is to assess the prevalence of MHE and driving skill impairment in cirrhotic patients who are regular drivers of four wheelers, using an electronic driving simulator.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.086
      Issue No: Vol. 6 (2016)
       
  • Profile of Anemia in Cirrhosis With or Without Sepsis
    • Authors: Apoorva Srijayadeva; B. Prashantha, Sandeep Gopal, Suresh Shenoy, Bailur Tantry
      Abstract: Background and Aim: Anemia is common in patients with cirrhosis and has been reported to be present in 75% of patients. Etiology of anemia in cirrhosis is multi factorial. Patients with cirrhosis have increased incidence of bacterial infections which could be associated with hematological abnormalities. Study was performed to identify the pattern of anemia in patients with cirrhosis and sepsis and its comparison with or without sepsis
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.085
      Issue No: Vol. 6 (2016)
       
  • Bone Mineral Density in Patients With Cirrhosis of Liver Awaiting Liver
           Transplantation
    • Authors: Pallav Parikh; Sharad Deshmukh, Sarojini Parameswaran, K.R. Palaniswami, N. Murugan, A.T. Mohan, Ubal Dhus, Usha Srinivas, P. Piramnayagam, M. Hariharan, V.P. Seshadri, M. Preethi
      Abstract: Background and Aim: There is association between cirrhosis and low bone mineral density (BMD) and limited data regarding prevalence of low BMD in patients awaiting liver transplantation in India. Aim of this study is to determine the prevalence of low BMD and factors associated with it in Indian patients with cirrhosis awaiting liver transplantation.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.084
      Issue No: Vol. 6 (2016)
       
  • Safety and Outcome of Protocol Based Injection of N-Butyl-2-Cyanoacrylate
           (GLUE) for Obliteration of Gastric Varix
    • Authors: Bhuvan Shetty; Avinash Balekuduru, Lokesh Locheruvapalli, Ravi Kiran, B.S. Satyaprakash
      Abstract: Background and Aim: In patients with portal hypertension at first endoscopy and of all variceal bleeds, 20% occur from gastric varices but outcome is worse than with esophageal variceal bleeding 1–3. The technique of endoscopic glue injection in gastric varix is not standardized. The aim of the study is to assess the efficacy and outcome of protocol based injection of glue injection at our center.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.083
      Issue No: Vol. 6 (2016)
       
  • Influence of Beta Blockers on Complications of Cirrhosis
    • Authors: Kayalvizhi Rajini; Rajkumar Solomon, Aravind Arumugham, Murali Ananthavadivelu, Balamurali Rangachari, Muthukumaran Kalyanasundaram, Ramkumar Govindarajan, Vaishnavi Priyaa, Kavitha S. Kumar
      Abstract: Background and Aim: Non-selective beta blockers (NSBB) are said to be protective against spontaneous bacterial peritonitis and worsen hepato renal syndrome, refractory ascites and hepatic encephalopathy in liver cirrhosis. We aimed to study the association of beta blockers with these complications in our center.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.082
      Issue No: Vol. 6 (2016)
       
  • Hidden From Endoscopic View Caught by Endosonography and Taken Care of
           Gastric Variceal Bleeding
    • Authors: Athish Shetty; Avinash Balekuduru, Lokesh Locheruvapalli, Ravi Kiran, Satyaprakash B. Shetty
      Abstract: Background: Gastric varices (GVs) are notorious to bleed massively and often difficult to manage with conventional techniques. GVs are known to bleed less frequently than the esophageal varices (EVs), but bleed massively and difficult to achieve primary hemostasis, with a mortality rate of 10%-30%. Once stabilised, an esophagogastroduodenoscopy (EGD) performed shows active bleeding/stigmata of recent bleeding/type of GVs and concomitant presence of EVs or PHG 1. Endoscopic ultrasound (EUS) enables the visualization of EVs, GVs and peri- and para-esophageal collateral veins and perforating veins.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.081
      Issue No: Vol. 6 (2016)
       
  • Predictors of in Hospital and 90-Day Mortality in Patients Admitted With
           Spontaneous Bacterial Peritonitis in a Tertiary Care Centre
    • Authors: Gopu R. Babu; M. Ramu, Ponni Krishnan, B. Bincy, Santosh K. Yadav, Shahna S. Fathima, Arun Iyer, Devadas Krishnadas, S. Srijaya, A. Shanid
      Abstract: Background and Aim: Bacterial infections are common in patients with cirrhosis. Spontaneous bacterial peritonitis (SBP) is the most prevalent infection in cirrhosis. Incidence of SBP is 10–30% with mortality ranging from 20% to 40%. The MELD was originally created and validated in patients in whom an acute reversible complication like infection or azotemia was not present and not to predict mortality. Of the available models, MELD is the most commonly used to predict mortality in decompensated CLD.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.080
      Issue No: Vol. 6 (2016)
       
  • To Study Upper Gastrointestinal Mucosal Changes in Patient With Portal
           Hypertension
    • Authors: Pinakin S. Patel; Deepak Amarapurkar
      Abstract: Background and Aim: Gastrointestinal bleeding accounts for up to 25% of overall mortality in patients with portal hypertension. Although variceal haemorrhage and peptic ulcer disease account for a significant portion of acute GI bleeding in cirrhotics, portal hypertensive gastropathy (PHG) and gastric antral vascular ectasia (GAVE) represent important causes of chronic gastrointestinal bleeding, responsible for chronic blood loss anaemia in 3–26% of patients. But their incidence was underestimated as cause of chronic iron deficiency anaemia in patient with portal hypertension.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.079
      Issue No: Vol. 6 (2016)
       
  • Prevalence of Malnutrition and Factors Associated With It, Among North
           Indian Cirrhotics Presenting to a Tertiary Care Centre
    • Authors: Kaushal Madan; Esha Gupta, Leena Saju, Pradeep Kumar, Maneesh Paliwal, Rajan Dhingra, Divij Mehta, Richa Bhargava, Manju Yadav
      Abstract: Background and Aim: Malnutrition is prevalent among cirrhotics. Limited data is available about the prevalence of and factors associated with malnutrition among Indian cirrhotics. To study the prevalence of malnutrition and factors influencing it, among cirrhotics presenting to a tertiary care hospital in India.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.100
      Issue No: Vol. 6 (2016)
       
  • Prospective Evaluation of Prognostic Factors in Cirrhotic Patients
           Requiring Intensive Care
    • Authors: Rohit Maidur; Sukanya Brugu, Nayana Joshi, Raghavendra Yarlagadda, Bubun Patel, Kunal Vyawahare, Gaurav Ratnaparkhi, Ajit Kumar
      Abstract: Background and Aim: The mortality in subjects with critically ill liver cirrhosis ranges between 36 and 86%. Various scoring systems and markers have been used to predict mortality in this set of patients. Serum ferritin is a representative of consequence of cell stress and damage. The present study is intended to find the parameters that influence outcome in cirrhotics requiring critical care.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.099
      Issue No: Vol. 6 (2016)
       
  • Factors Predicting Failure of 3rd Generation Cephalosporins in Treatment
           of Spontaneous Bacterial Peritonitis
    • Authors: M. Ramu; Gopu R. Babu, K. Sreejith, Nikhil Suraj, G. Chethan, T.S. Prasanth, Deni Joseph, A. Shanid, S. Srijaya, Selwyn Noronha, D. Krishnadas
      Abstract: Background and Aim: Spontaneous bacterial peritonitis (SBP) is the most prevalent bacterial infection in patients with cirrhosis. Cefotaxim has been considered the first choice of empirical antibiotic for the treatment of SBP. Studies from different parts of world have reported significant rates of resistance to third-generation cephalosporins. The aim of the study is to find the factors predicting failure of 3rd generation cephalosporins in treatment of SBP in decompensated cirrhosis patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.098
      Issue No: Vol. 6 (2016)
       
  • Is Low Dose Synacthen Test Reliable in Detecting Adrenal Insufficiency in
           Cirrhosis
    • Authors: Deni Joseph; D. Krishnadas, A. Shanid, S. Sreejaya, K.S. Prasanth, K. Sreejith, Ramu Muraleedaran, S. Sandeep, Rathan Cyriac, K. Gaurav, S. Varun
      Abstract: Background and Aim: To detect adrenal insufficiency in cirrhosis using low dose (1μg) synacthen test and to compare it with, S. cortisol and salivary cortisol. Background adrenal insufficiency is very common in CLD. Even in stable CLD patients various studies showed prevalence of cirrhosis varying from 20 to 70%. Free cortisol is the most reliable method used for estimation of adrenal insufficiency. But it is expensive and time consuming. Salivary cortisol in various studies correlated well with free cortisol.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.097
      Issue No: Vol. 6 (2016)
       
  • Normal Values for Psychometric Tests, for Kerala; and Its Evaluation in
           Cirrhotic Patients
    • Authors: Jeesemon Jose; Mathews Choracken, Roy Mukkada, Antony Chettupuzha, Jose Francis, Abraham Koshy
      Abstract: Background and Aim: Normal values of tests used for minimal hepatic encephalopathy (MHE), is dependent on education and age. In addition, it needs to be established for each society. Normal values for Kerala, South India, has not been established. The aim of the study is to establish normal values for each psychometric test used as part of MHE assessment for Kerala, South India and to use these to determine the prevalence of minimal hepatic encephalopathy in cirrhotic patients and to correlate with clinical parameters.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.096
      Issue No: Vol. 6 (2016)
       
  • Study of Common NOD2 Gene Polymorphisms as a Risk Factor for Development
           of Complications in Indian Patients of Liver Cirrhosis
    • Authors: Manish Tiwari; Mohd T. Noor, Nivesh Seehra, Sunil Jain, Ravindra Kumar, Bhagwan S. Thakur
      Abstract: Background and Aim: Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene polymorphism promotes bacterial translocation (BT), which plays a crucial role in the pathogenesis of many complications of cirrhosis. These polymorphisms are recently identified as an important genetic risk factor for the development of spontaneous bacterial peritonitis (SBP) in western patients of liver cirrhosis. Our aim was to see the association of these polymorphisms with SBP and other major complications of cirrhosis involving BT in Indian patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.095
      Issue No: Vol. 6 (2016)
       
  • Granulocyte Colony Stimulating Factor Mobilizes CD34 Cells and Improves
           Survival of Patients With Decompensated Cirrhosis: A Randomized Controlled
           Trial
    • Authors: Ritesh Prajapati; Anil Arora, Praveen Sharma, Naresh Bansal, Vikas Singla, Ashish Kumar
      Abstract: Background and Aim: Liver transplantation is the only curative treatment modality for decompensated cirrhosis; however, it is limited by donor organ availability, high cost, operative risk, and long-term complications. Besides, many patients die while on liver transplant waiting list. The contribution of granulocyte colony stimulating factor (GCSF) induced mobilization of bone marrow stem cells to tissue regeneration has been recognized and there is considerable interest in the potential benefits of GCSF therapy in patients with advanced liver disease.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.094
      Issue No: Vol. 6 (2016)
       
  • Relationship of Serum Sodium With Complications of Cirrhosis Prospective
           Study in Tertiary Medical Center of Rajasthan
    • Authors: Ram P. Singh; Dhawal Vyas, Gaurav Gupta, Hemendra Bharadwaj, Sandeep Nijhawan
      Abstract: Background and Aim: Hyponatremia is an independent predictor of mortality in patients of cirrhosis, but its clinical importance and prevalence is unclear. In this study we aimed at identifying prevalence of hyponatremia and relationship between serum sodium levels and severity of ascites and complications of cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.093
      Issue No: Vol. 6 (2016)
       
  • Can Non-invasive Parameters Help Us to Predict Large Esophageal
           Varices' Results from a Tertiary Medical Centre of Rajasthan
    • Authors: Dhawal Vyas; Ram P. Singh, Gaurav Gupta, Sandeep Nijhawan
      Abstract: Background and Aim: Current consensus recommend screening cirrhotics patients with endoscopy to detect esophageal varices and to begin prophylactic management in patients having large esophageal varices. This study was aimed at finding non-invasive parameters which could identify the presence of large esophageal varices.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.092
      Issue No: Vol. 6 (2016)
       
  • Spontaneous Bacterial Peritonitis by Burkholderia Cepacia Complex: A Rare,
           Difficult to Treat Infection in Decompensated Cirrhotic Patients
    • Authors: Pramod Kumar; Sunil Taneja, Vikas Gautam, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Yogesh K. Chawla
      Abstract: Background and Aim: Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication of decompensated cirrhosis. Burkholderia cepacia complex (Bcc) is non-fermenting Gram-negative bacillus with high intrinsic antibiotic resistance and has been rarely reported to cause SBP in decompensated cirrhosis. This study was done to evaluate the clinical presentation of cirrhotic patients with SBP due to Bcc and to determine its impact on clinical outcome.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.091
      Issue No: Vol. 6 (2016)
       
  • Comparison of Clinical and Laboratory Profile Between Alcoholic and
           Cryptogenic Cirrhosis in Coastal Odisha
    • Authors: Suryakanta Parida; Preetam Nath, Ayaskanta Singh, Girish Pati, Shivaram Singh, Kaibalya Dash, Sambit Behera, Prasanta Parida
      Abstract: Background and Aim: Patients with cryptogenic cirrhosis (CC) have different clinico-biochemical profile and survival pattern than cirrhosis due to other etiologies. The aim of the study was to compare clinical and laboratory profile between hospitalised alcoholic (AC) and CC cases in a tertiary care hospital in Coastal Odisha.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.090
      Issue No: Vol. 6 (2016)
       
  • Cirrhotic Fundal Variceal Bleeders Have Lower Portal Pressure as Compared
           to Cirrhotic Esophageal Variceal Bleeders: A Comparative Analysis of 80
           Patients
    • Authors: Shrihari Anikhindi; Ashish Kumar, Praveen Sharma, Vikas Singla, Naresh Bansal, Anil Arora
      Abstract: Background and Aim: Variceal bleeding is a common manifestation of portal hypertension in liver cirrhosis. There is inadequate data comparing portal pressures in patients who bleed from esophageal (EV) or fundal varices (FV). We compared hepatic venous pressure gradient (HVPG) in patients with EV and FV, who were admitted to our institute with past or recent history of variceal bleeding.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.089
      Issue No: Vol. 6 (2016)
       
  • Silibinin Induced Cell Cycle Arrest in Human Hepatic Stellate Cells
    • Authors: Ezhilarasan Devaraj
      Abstract: Background and Aim: Proliferation of hepatic stellate cells (HSCs) plays pivotal role in the progression of hepatic fibrosis consequent to chronic liver injury. Silibinin (SBN), a flavonoid compound, has been shown to possess anti-fibrogenic effects in animal models of liver fibrosis. This was attributed to an inhibition of cell proliferation of activated HSCs. To gain insight into the molecular pathways involved in SBN anti-fibrogenic effect, the current work was undertaken to evaluate the mechanisms behind the anti-proliferative and cell cycle arresting properties of SBN.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.088
      Issue No: Vol. 6 (2016)
       
  • Liver Function Test Abnormalities in an Epidemic of Dengue Viral Infection
           and its Correlation with Platelet Values—A Tertiary Care Experience
    • Authors: Vinoth Boopathy
      Abstract: Background and Aim: Liver function test (LFT) abnormalities are commonly seen in patients with dengue viral infection, though the role of variation in the levels of liver enzymes in the pathogenesis of dengue severity is not known yet. In this context we conducted a retrospective study to analyse the clinical spectrum of dengue with regard to LFT abnormalities in patients with dengue fever and its association with disease severity from a recent epidemic in a tertiary care centre of south India.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.125
      Issue No: Vol. 6 (2016)
       
  • Bacteriological Profile and Antibiotic Sensitivity in Acute Cholangitis
    • Authors: Abhijith Bale; Anurag Shetty, Girisha Balaraju, Shiran Shetty, Ganesh Pai
      Abstract: Background and Aim: Acute cholangitis usually complicates biliary obstruction or stasis and carries a mortality rate as high as 30%. Antibiotic therapy plays a major role, as an adjunct to adequate biliary drainage in cholangitis. The changing antibiotic sensitivity pattern of bacterial infections in general, effects cholangitis too and knowledge of bacterial epidemiology in cholangitis helps choose antibiotic wisely. The aim of the study was to analyze the clinical and bacteriological profile, in acute cholangitis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.124
      Issue No: Vol. 6 (2016)
       
  • Concurrent Extrahepatic Autoimmune Disorders: Unexplored Dimension of
           Autoimmune Liver Disease in the Children
    • Authors: Vikas Jain; Surender Yachha, Eesh Bhatia, Moinak Sarma, Anshu Srivastava, Ujjal Poddar
      Abstract: Background and Aim: No comprehensive and prospective data is available on concurrent extrahepatic autoimmune disorders (CEAIDs) in children with autoimmune liver disease (AILD). The aim of the study was to evaluate CEAIDs in AILD and evaluate their effect on AILD outcome.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.123
      Issue No: Vol. 6 (2016)
       
  • Lane-Hamilton Syndrome: Atypical Presentation of Celiac Disease
    • Authors: Sajan Agarwal; Raj Gupta
      Abstract: Background and Aim: Celiac disease (CD) is defined as a chronic, immune-mediated enteropathy of the small intestine, caused by exposure to dietary gluten in genetically predisposed individuals. Idiopathic Pulmonary Hemosiderosis (IPH) is a rare cause of alveolar hemorrhage, which is seen primarily in childhood. Association of CD with idiopathic pulmonary hemosiderosis (IPH) is known as Lane-Hamilton syndrome and is somewhat a rarely seen condition. There are limited numbers of case reports of this syndrome in literature.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.122
      Issue No: Vol. 6 (2016)
       
  • Factors Affecting Serum AFP in HCC
    • Authors: Shahna S. Fathima; G. Chethan, T.S. Prasanth, Krishnadas Devadas, Selwyn Noronha, S. Srijaya, A. Shanid, K.S. Prasanth, George Peter, Arun Iyer, B.K. Bincy, Gopu R. Babu, Ponni Krishnan, Santosh Yadav
      Abstract: Background and Aim: Previous studies on Alpha FetoProtein (AFP) and (Hepato Cellular Carcinoma) HCC are heterogeneous as far as stage and etiology of liver disease is concerned. Consequently AFP is considered to have suboptimal performance as a diagnostic and surveillance marker. This study aims to find factors affecting serum AFP in HCC so as to find why AFP level varies in HCC.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.120
      Issue No: Vol. 6 (2016)
       
  • Etiological and Clinical Characteristics of Hepatocellular Carcinoma at
           Presentation to Tertiary Care Hospital in South India
    • Authors: Chethan Govindaraju; Prasanth Sudheendran, Nikhil Suraj, Gunjal Sudamrao, Singh Anirudha Pratap, George Peter, Shanid Sathar, Prasanth Sobhan, Srijaya Sreesh, Selwyn Noronha, Krishnadas Devadas
      Abstract: Background and Aim: To analyze the etiology, clinical presentation and tumor characteristics of Hepatocellular carcinoma (HCC) presenting to tertiary care hospital.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.119
      Issue No: Vol. 6 (2016)
       
  • Post-transarterial Chemoembolization Liver Failure is Associated With Poor
           Outcome in Hepatocellular Carcinoma
    • Authors: Neeti Nadda; Shalimar, Saurabh Kedia, Baibaswata Nayak, Dawesh Yadav, Mona Pathak, Shashi B. Paul, Subrat K. Acharya
      Abstract: Background and Aim: Transarterial chemoembolization (TACE) is the recommended treatment of BCLC-A and B stages of hepatocellular carcinoma (HCC), when curative options are not feasible. Post-TACE decompensation is common. In this analysis of a prospectively acquired database, we aimed to determine the predictors of post-TACE liver failure (LF), and its effect on natural course of HCC.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.118
      Issue No: Vol. 6 (2016)
       
  • A Case of Autoimmune—MIMIC Jaundice
    • Authors: Jasmeet Singh Dhingra
      Abstract: Background: In AIH, auto-antibodies can be detected in up to 95% patients. Our report describes a case of 46-year-old woman with an ovarian mass and unremitting jaundice with biopsy features of early AIH and with both initial CA-125 and ANA negative which finally turned out be metastatic cause of jaundice.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.117
      Issue No: Vol. 6 (2016)
       
  • Does Preoperative Imaging Correlate With Explant Pathology in HCC'
    • Authors: Joy Varghese; Mayank Jain, Mukul Vij, Sanjay Govil, Deepashree M. Reddy, V. Jayanti, Mohamed Rela
      Abstract: Background and Aim: To assess the correlation of findings noted on preoperative CT scan with pathological examination of liver explants in patients who underwent liver transplant (LT) for hepatocellular carcinoma (HCC).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.116
      Issue No: Vol. 6 (2016)
       
  • Non Favorable Genotype is Predominant at IL28B RS12979860 Polymorphism in
           Hepatitis B Related Hepatocellular Carcinoma
    • Authors: Abu Saleh Mohammmad Sadequl Islam
      Abstract: Background and Aim: The highest incidence of HCC is in Asia, accounting for about 76% of all cases worldwide. In South East Asia, hepatitis B is the most common underlying cause. Although numerous associations between environmental factors (e.g. cigarette smoking, heavy alcohol drinking, male gender, older age), viral factors (e.g. viral load, active replication, genotype, core promoter mutations) and the development of HCC in chronic HBV infection have been identified, a clear understanding of the role of host genetics remains illusive.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.115
      Issue No: Vol. 6 (2016)
       
  • Does Diabetes Mellitus Alter the Clinical and Biochemical Characteristics
           of Hepatocellular Carcinoma Patients—A South Indian Experience
    • Authors: Prasanth Sudheendran; G. Chethan, Nikhil Suraj, Deni Joseph, K. Srijith, M. Ramu, S. Prasanth, A. Shanid, Srijaya Sreesh, Selwyn Noronha, D. Krishnadas
      Abstract: Background and Aims: Recent studies suggested a strong association between diabetes mellitus and Hepatocellular carcinoma (HCC) in males and females independent of the geographic location, alcohol consumption, Hepatitis B or C (HBV or HCV) infection. We tried to find out if diabetes mellitus alter the clinical and biochemical characteristics of HCC patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.114
      Issue No: Vol. 6 (2016)
       
  • Primary Malignant Melanoma of Liver–A Report of 2 Cases
    • Authors: Girish P. Veeranna; Vishnu Vardhan Reddy, Tarun Sabastian Joseph, Balaji Gurappa, Vishnu Abishek Raju, Mallikarjun Patil, Harshad C. Devarbhavi
      Abstract: Background: Malignant melanoma is extremely aggressive cancer arising from melanocytes. 90% of all melanomas are of cutaneous origin, although liver is a frequent site of metastasis from melanoma. Primary hepatic melanoma (PHM) is rare.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.113
      Issue No: Vol. 6 (2016)
       
  • Differential Expression of Circulating miRNAs Among Healthy, Diseased
           Controls and HCC Patients—Pilot Study
    • Authors: Baibaswata Nayak; Neeti Nadda, Dawesh Yadav, Shashi B. Paul, Shalimar, Subrat K. Acharya
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Hepatitis B or C is the most common cause of HCC. Majority of the patients of HCC have advanced disease at the time of diagnosis for which locoregional therapy remains the mainstay of treatment. Assessment of post treatment response is based on the imaging modalities like computed tomography or magnetic resonance imaging. There is a need to identify a novel diagnostic and prognostic biomarker for HCC.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.112
      Issue No: Vol. 6 (2016)
       
  • Unusual Paraneoplastic Presentation of Hodgkins Lymphoma as Isolated
           Idiopathic Intrahepatic Cholestasis With Ascites
    • Authors: C. Palanivelu; T.S. Ramesh, Junaid Khan
      Abstract: Background: Intrahepatic cholestasis presenting as paraneoplastic manifestation is a rare form of presentation in Hodgkin's lymphoma (HL).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.111
      Issue No: Vol. 6 (2016)
       
  • Clinical and Etiological Profile of Hepatocellular Carcinoma in a North
           Indian Patient
    • Authors: Pankaj K. Asati; Sunit Shukla, Ashok Jain, Vinod K. Dixit
      Abstract: Background and Aim: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. HCC is the leading cause of cancer related death worldwide. HCC is the 5th most common cancer in the world and the third most common cause of cancer related death. HCC have varied clinical presentations. The aim of the study was to assess the etiological and clinical profile of Hepatocellular Carcinoma.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.110
      Issue No: Vol. 6 (2016)
       
  • Macrophage Inflammatory Protein-1Alpha/CC Chemokine Ligand 3 and
           Tumor-Associated Macrophages in Hepatitis C Virus-Related Hepatocellular
           Carcinoma: Relation to Tumor Progression and Angiogenesis
    • Authors: Hoda E. Aggan; Myriam Helmy, Nevine E. Deeb, Ahmed Zeid, Mohamed Fawzy
      Abstract: Background and Aim: Hepatitis C virus (HCV) is a major risk factor for hepatocellular carcinoma (HCC). Chemokines induce leukocyte migration and activate inflammatory response and have recently been implicated in tumor growth. The present work was designed to study the role of macrophage inflammatory protein-1alpha/CC chemokine ligand 3 (MIP-1alpha/CCL3) in the pathogenesis of HCV-related HCC in relation to tumor progression and angiogenesis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.109
      Issue No: Vol. 6 (2016)
       
  • Regression of Large Unresectable Hepatoma With Sorafenib
    • Authors: Vishnu V. Reddy; P.V. Girish, Tarun Joseph, G. Balaji, Vishnu A. Raju, Mallikarjun Patil, Harshad Devarbhavi
      Abstract: Background: Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. Currently, Sorafenib is the only systemic treatment modality approved for unresectable or metastatic HCC, which has demonstrated efficacy in improving Progression-Free Survival (PFS). Complete response of the tumor to sorafenib has never been documented.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.108
      Issue No: Vol. 6 (2016)
       
  • Lung Lesion With HCC—Not Always Metastasis
    • Authors: Pavan B. Hanchanale; Dinesh Jothimani, Joy Varghese, Venkataraman Jayanthi, Mohamed Rela
      Abstract: Background: We present a unique case of synchronous cancers—primary HCC and primary pulmonary carcinoid tumor.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.107
      Issue No: Vol. 6 (2016)
       
  • Combination of TACE and Sorafenib Improves Outcomes in BCLC Stages B/C of
           Hepatocellular Carcinoma: A Single Centre Experience
    • Authors: Joy Varghese; Chandan Kedarisetty, Jayanthi Venkataraman, Kavya Harika, Vijaya Sreenivasan, Tiruchunapalli Deepashree, Mangerira Uthappa, Kaliamurthy Ilankumaran, Sanjay Govil, Mettu Reddy, Mohamed Rela
      Abstract: Background and Aim: Transarterial chemoembolization (TACE) or sorafenib is recommended for hepatocellular carcinoma BCLC stages B and C respectively. We studied the role of TACE+sorafenib in BCLC stages B/C.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.106
      Issue No: Vol. 6 (2016)
       
  • Comparative Effectiveness of Different Pharmacological Interventions for
           the Treatment of Minimal Hepatic Encephalopathy: A Systematic Review With
           Network Meta-Analysis
    • Authors: Radha K. Dhiman; Kiran K. Thumburu, Madhu Chopra, Usha Dutta, Meenu Singh, Sunil Taneja, Ajay Duseja, Yogesh K. Chawla
      Abstract: Background and Aim: Minimal hepatic encephalopathy (HE) is associated with impaired quality of life and increased progression to overt HE. We assessed the comparative effectiveness of pharmacological interventions for the reversal of minimal HE and for prevention of development of overt HE through network meta-analysis combining direct and indirect treatment comparisons of randomized clinical trials (RCTs).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.104
      Issue No: Vol. 6 (2016)
       
  • Burden of Cirrhosis and Minimal and Past History of Overt Hepatic
           Encephalopathy on Patients and Caregivers
    • Authors: Deepa Shrestha; Radha K. Dhiman, Sandeep Grover, Sunil Taneja, Ajay Duseja, Yogesh K. Chawla
      Abstract: Background and Aim: Hepatic encephalopathy (HE) is associated with impaired health-related quality of life in patients with liver cirrhosis. However, HE causing significant socioeconomic and emotional impact over the caregiver is not clearly defined. This study was carried out to assess the overall emotional and socioeconomic burden of minimal and overt HE over liver cirrhosis patients and their caregivers.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.103
      Issue No: Vol. 6 (2016)
       
  • Influence of Beta Blockers on Complications of Cirrhosis
    • Authors: Kayalvizhi Rajini; T. Rajkumar Solomon, Aravind Arumugham, Murali Ananthavadivelu, Balamurali Rangachari, Muthukumaran Kalyanasundaram, Ramkumar Govindarajan, C. Vaishnavi Priyaa, S. Kavitha
      Abstract: Background and Aim: Non-selective beta blockers (NSBB) are said to be protective against spontaneous bacterial peritonitis and worsen hepatorenal syndrome, refractory ascites and hepatic encephalopathy in liver cirrhosis. We aimed to study the association of beta blockers with these complications in our center.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.102
      Issue No: Vol. 6 (2016)
       
  • Study on the Predictors of Response to Terlipressin Plus Albumin in
           Hepatorenal Syndrome (HRS) Type 1
    • Authors: Manasa; Girinadh, Muralikrishna Manne, Kaibalya R. Dash
      Abstract: Background and Aim: Terlipressin plus albumin is an effective treatment for type 1 hepatorenal syndrome (HRS), but approximately only half of the patients respond to this therapy. The aim of this study was to assess predictive factors of response to treatment with terlipressin and albumin in patients with type 1 HRS.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.101
      Issue No: Vol. 6 (2016)
       
  • Seroprevalence of Schistosomiasis in CLD Cases from Upper Assam
    • Authors: Tanu Arora; Anup Das, Biswajyoti Borkakoty, Munmun Gohain
      Abstract: Background and Aim: Schistosomiasis is associated with hepatic granuloma formation, causing fibrosis which leads to pre-sinusoidal portal hypertension and its sequelae. Non-human schistosomiasis is also reported from the Indian subcontinent. Present study was conducted in Assam Medical College and Hospital located in upper Assam to find schistosoma seroprevalence.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.138
      Issue No: Vol. 6 (2016)
       
  • Hepatorenal Fibrocystic Disease Spectrum in 2 Sisters
    • Authors: Sajan Agarwal; Raj Gupta, Anu Bhandari, Kalpana Mangal
      Abstract: Background: Caroli's syndrome (CS) is a rare congenital disorder characterized by multiple segmental cystic or saccular dilatations of the intrahepatic bile ducts and congenital hepatic fibrosis(CHF). The clinical features of this syndrome reflect both the characteristics of CHF such as hepatic fibrosis, portal hypertension, and renal cystic disease and that of Caroli's disease (CD) named as recurrent cholangitis and cholelithiasis. CS is associated with renal involvement in up to 60% of patients and implies a dilatation of the collecting renal tubules.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.137
      Issue No: Vol. 6 (2016)
       
  • Profile of DILI in Patients with Chronic Liver Disease
    • Authors: S. Shiraz; Rajesh Gopalakrishna, C.M. Neethu, P. Nair, Rama Venu
      Abstract: Background and Aim: Patients with chronic liver disease (CLD) may be more susceptible to drug induced liver injury (DILI) via reduced drug clearance, aberrant metabolism, altered excretion, or impaired adaptive responses. Diagnosis of DILI may identify a reversible cause for acute decompensation. The aim of the study the profile and outcomes of DILI in CLD patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.136
      Issue No: Vol. 6 (2016)
       
  • Seronegative Autoimmune Hepatitis Presents with More Severe Disease But
           Has Similar Outcomes as Compared to Seropositive Patients
    • Authors: Nikhil Sonthalia; Pravin Rathi, Samit Jain, Ravindra Surude, Ashok Mohite, Sunil Pawar, Qais Contractor
      Abstract: Background and Aim: Severe acute presentation is an uncommon manifestation of autoimmune hepatitis (AIH) and it remains poorly characterized. The aim was to study natural history and treatment outcomes of AIH variants presenting with severe-AIH.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.135
      Issue No: Vol. 6 (2016)
       
  • Characteristics Of Congenital Hepatic Fibrosis and Caroli's Disease:
           Experience of a Tertiary Care Center in the Ciliopathy of Childhood
    • Authors: Brijnandan Gupta; Prasenjit Das, Rajni Yadav, Shalimar, S.K. Acharya, K.S. Madhusudan, S.K. Panda, Siddhartha Datta Gupta
      Abstract: Background and Aim: Congenital hepatic fibrosis (CHF) is considered as variant of autosomal recessive polycystic kidney disease (ARPKD) affecting children and adolescents. Inheritance pattern is autosomal recessive and affected gene is PKHD1 located on chromosome 6p21, which encodes protein fibrocystin present on cilia of renal tubules and intrahepatic bile ducts. CHF may be associated with Caroli disease. We aimed at characterizing the histopathological features of these rare diseases and tried to correlate with radiological features, wherever available.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.134
      Issue No: Vol. 6 (2016)
       
  • Shear Wave Elastography for Assessment of Liver Fibrosis in Chronic
           Hepatitis: Pilot Work
    • Authors: Shashi B. Paul; Prasenjit Das, Hanish Sharma, Maneesh Vijayvargiya, Shouriyo Ghosh, R. Vidyasagar, Dawesh Yadav, Shivanand R. Gamanagatti, Siddhartha Gupta, Subrat K. Acharya
      Abstract: Background and Aim: Shear wave elastography (SWE) is a novel ultrasound technique used for detecting liver fibrosis in patients of chronic hepatitis (CH). Assessment of fibrosis is based on the liver stiffness assessed both in qualitative and quantitative manner. We evaluated CH patients [hepatitis B (CHB), hepatitis C (CHC)] and compared the results with the reference method of liver biopsy.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.133
      Issue No: Vol. 6 (2016)
       
  • Transarterial Chemotherapy (TAC) Versus Oral Chemotherapy in the Treatment
           of Unresectable Hepatocellular Carcinoma with Portal Vein Thrombosis: A
           Randomized Controlled Trial
    • Authors: Shashi B. Paul; Shivanand R. Gamanagatti, Vishnubhatla Sreenivas, Devesh P. Yadav, Neeti Nada, Baibaswata Nayak, Shalimar, Subrat K. Acharya
      Abstract: Background and Aim: Majority of the HCC patients report to the hospital in an advanced stage when no curative therapies can be offered. Vascular involvement (main portal vein thrombosis) limits their therapeutic options. Palliative treatment in the form of chemotherapy becomes the main stay of treatment in such advanced cases. Transarterial chemotherapy (TAC) has been tried by few researchers. Currently, radioembolization is recommended for such patients. However, it is costly and has limited availability.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.132
      Issue No: Vol. 6 (2016)
       
  • Diagnostic Conundrum of Infantile Glycogen Storage Disorder with Myopathy
    • Authors: Aruna Chhikara; Sarika Singh, Brijnandan Gupta, Mariya Ansari
      Abstract: Background: Glycogen storage diseases (GSD) are inherited metabolic disorders of glycogen metabolism. The overall GSD incidence is estimated 1 case per 20,000–43,000 live births. There are only a few case reports about GSD in India. There are over 12 types of GSD and they are classified based on the enzyme deficiency and the affected tissue. Disorders of glycogen metabolism may affect primarily the liver, the muscle, or both.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.131
      Issue No: Vol. 6 (2016)
       
  • Comparison of Transient Elastography and Shear Wave Elastography in the
           Evaluation of Liver Fibrosis
    • Authors: Nikhil Suraj; Gopu R. Babu, Rathan C. Joseph, K. Srijith, Srijaya Sreesh, K.S. Prasanth, A. Shanid, Devadas Krishnadas
      Abstract: Background and Aim: Several non-invasive methods have been developed for the evaluation of liver fibrosis. Our primary aim was to compare the efficacy of shear wave elastography (SWE) and transient elastography (TE) in determining liver fibrosis among patients with chronic liver disease.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.130
      Issue No: Vol. 6 (2016)
       
  • Clinical Profile of Hepatic Wilson Disease in Tertiary Center
    • Authors: Gaurav Garg; Vinod Dixit, Sunit Shukla, Pankaj Asati, Sudhir Singh, Shivam Sachan
      Abstract: Background and Aim: Wilson disease is a rare autosomal recessive inherited disorder of copper metabolism that is characterized by excess deposition of copper in the liver, brain, and other tissues. Hepatic dysfunction is the presenting feature in more than half of patients. In this study we assess the clinical profile of Wilson's disease in hospitalized liver disease related patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.129
      Issue No: Vol. 6 (2016)
       
  • Benign Recurrent Intrahepatic Cholestasis (Summerskill Walshe Tygstrup
           Disease)—A Case Report
    • Authors: G.S. Gurudath; C. Palanivelu, J. Khan Mohammad, K.T.S. Ramesh, K.G.S. Sharath, Palve Santhosh, Dhinakaran Suganya, Sharma Nithyanand, Murudawar Piyush
      Abstract: Background: Benign Recurrent Intrahepatic Cholestasis (BRIC) is a rare form of hereditary cholestasis syndrome characterized by self limiting episodes of pruritis and cholestasis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.128
      Issue No: Vol. 6 (2016)
       
  • Study to Compare HVPG with Endoscopy of UGIT to Assess Severity of Portal
           Hypertension in Cirrhotics in Bangladesh
    • Authors: Mohammad Abdur Rahim; Mamun A. Mahtab, Sheikh Mohammad Noor-E-Alam, Mohammad Ashraful Alam, Ahmed Lutful Moben, Syed Abul Foez, Mohammad Helal Uddin, Sheikh Mohammad Fazle Akbar, Salimur Rahman
      Abstract: Background and Aim: Aim of the study was to compare the utility of hepatic venous pressure gradient (HVPG) and endoscopy of upper gastrointestinal tract (UGIT) for the assessment of severity of portal hypertension in liver cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.127
      Issue No: Vol. 6 (2016)
       
  • Pilot Study to Access Safety and Efficacy of Granulocyte Colony
           Stimulating Factor Therapy in Decompensated Cirrhotics in Bangladesh
    • Authors: Mohammad Helal Uddin; Mamun A. Mahtab, Mohammad Abdur Rahim, Sheikh Mohammad Noor-E-Alam, Ahmed Lutful Moben, Syed Abul Foez, Sheikh Mohammad Fazle Akbar, Salimur Rahman
      Abstract: Background and Aim: Currently there is no specific treatment for decompensated cirrhosis, excluding liver transplantation, which is available in limited centres and is also is restricted by shortage of donor organs, limited expertise and cost. Stimulation of stem cells with GCSF injection may help hepatic regeneration in such patients and thus delay the need for liver transplantation. Aim of study is to assess safety and efficacy of granulocyte colony stimulating factor (GCSF) therapy in decompensated cirrhosis as GCSF is known to stimulate stem cells humans.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.126
      Issue No: Vol. 6 (2016)
       
  • Transient Elastography (Fibroscan) in Patients with Non-Cirrhotic Portal
           Fibrosis
    • Authors: Rachit Agarwal; Praveen Sharma
      Abstract: Background and Aim: Non-cirrhotic portal hypertension (NCPH) is a common cause of variceal bleed in developing countries. Transient elastography (TE) using Fibroscan is a useful technique for evaluation of fibrosis in patients with liver disease. There is no study evaluating TE in patients with non-cirrhotic portal fibrosis (NCPF). The aim of this study was to evaluate the role of TE in NCPF.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.152
      Issue No: Vol. 6 (2016)
       
  • Acoustic Radiation Force Imaging Elastography Correlation with Liver
           Biopsy in the Evaluation of Staging of Liver Fibrosis
    • Authors: Usha Goenka; Chinmay Bera, M.D. Nadeem Parvez, Enam Khan, Mahesh Goenka
      Abstract: Background and Aim: Acoustic radiation force elastography (ARFI) is a novel technique for non-invasive assessment of liver fibrosis. In comparison to transient elastography, ARFI can be done in obese patients and at multiple sites of liver. Aim of this study was to investigate the accuracy of ARFI imaging as a non-invasive method for the assessment of liver fibrosis compared to histologic liver fibrosis score.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.151
      Issue No: Vol. 6 (2016)
       
  • Thromboelastography Analysis in Patients with Cirrhosis and its
           Correlation with Conventional Coagulation Parameters
    • Authors: Rachit Agarwal; Piyush Ranjan
      Abstract: Background and Aim: Conventional parameters of coagulation such as prothrombin time (PT) do not accurately assess the coagulation profile in cirrhosis because of reduction in both anticoagulant and procoagulant factors. Thromboelastography (TEG) is a rapid viscoelastic test of coagulation that assesses clot formation in whole blood, including plasmatic and cellular components. The aim of this study was to see correlation of TEG with conventional coagulation tests and severity of liver disease (CTP score).
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.150
      Issue No: Vol. 6 (2016)
       
  • Hepatic Sarcoidosis
    • Authors: Anil Pal; Amey Sonawane, Deepak Amarapurkar
      Abstract: Background and Aim: Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology. It primarily affects the lungs and hilar lymph nodes. Hepatic sarcoidosis (HS) is an infrequent extrapulmonary site of disease. The aim of our study was to assess the clinical features, disease characteristics and treatment response of patients with HS.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.149
      Issue No: Vol. 6 (2016)
       
  • ADAMTS13 Mutations Associated with Defective ADAMTS13 Secretion in a
           Patient with Non-Cirrhotic Portal Hypertension
    • Authors: Ashish Goel; V. Raghupathy, G.J. Amirtharaj, Aaron Chapla, Aparna Ramachandran, Saravanan Sureshkumar, K.A. Balasubramanian, Anup Ramachandran, B. Ramakrishna, Nihal Thomas, Ian Mackie, C.E. Eapen, Elwyn Elias
      Abstract: Background and Aim: ADAMTS13 (a disintegrin like and metalloproteinase with thrombospondin type 1 motifs—13)—vWF (von-Willebrand factor) imbalance in non-cirrhotic intrahepatic portal hypertension (NCIPH) raises possibility of a mutation in CUB domain (exons 26, 27) of ADAMTS13 gene. We looked for such ADAMTS13 mutations in NCIPH.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.148
      Issue No: Vol. 6 (2016)
       
  • A Rare Case of Budd Chiari Syndrome Secondary to Anti Phospholipid
           Antibody Syndrome and Inherited Thrombophilia
    • Authors: Saikrishna Katepally
      Abstract: Background: Budd Chiari Syndrome is a heterogenous condition characterised by hepatic venous outflow obstruction at the level of hepatic veins and/or inferior vena cava.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.147
      Issue No: Vol. 6 (2016)
       
  • Granulomatous Hepatitis Complicating Intravesical Bacille Calmette-Guérin
           (BCG) Therapy for High-Risk Superficial Bladder Cancer
    • Authors: Arun Iyer; Prasanth Sudheendran, Shanid Sathar, Sreejaya Sreesh, Krishnadas Devadas
      Abstract: Background: Intravesical bacille Calmette-Guérin (BCG) therapy is the most effective treatment for high-risk superficial bladder cancer. Severe systemic complications are rare, but may occur in approximately 1% of cases.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.146
      Issue No: Vol. 6 (2016)
       
  • Pancreatic Exocrine Insufficiency in Diabetes
    • Authors: Syed Afzal; Masi-ur-Rehman Ajmal, Ashaq Dar, Sheelu Siddiqi
      Abstract: Background and Aim: PEI is frequently seen in DM. More than 50% of patients have pancreatic fibrosis and atrophy. The present study is designed to evaluate PEI in Type 1 and Type 2 DM. Primary aim: evaluate PEI in DM. Secondary aims: to co-relate degree of PEI with duration of diabetes, PEI with diabetic neuropathy and size of pancreas with duration of diabetes.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.145
      Issue No: Vol. 6 (2016)
       
  • Collagen Rich Scaffolds for Liver Engineering: A Step Forward to an
           Artificial Liver
    • Authors: Catherine Martin; R. Subathra, V. Jayanthi, Srinivas Reddy, Joy Varghese, Mohammed Rela, Narayana Kalkura
      Abstract: Background and Aim: Tissue engineering is a new and emerging field which tries to regenerate human tissues with the help of cells, bioactive molecules and biomaterials such as scaffolds. There are more than 100 liver diseases due to the complex function of the liver. To overcome this condition, the present study aims at developing a scaffold which will be congenial for growth of hepatocytes.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.144
      Issue No: Vol. 6 (2016)
       
  • A Profile of AIH from India
    • Authors: Sunil Taneja
      Abstract: Background and Aim: The spectrum of neurological dysfunction in cirrhosis varies from mild cognitive impairment to a full blown extrapyramidal syndrome referred to as hepatocerebral degeneration. There is however little information about the clinical significance of extrapyramidal signs associated with cirrhosis, and it is not known if the existence of the extrapyramidal signs influences the prevalence of MHE and daily-life activities or health-related quality of life (HRQOL) of patients with cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.143
      Issue No: Vol. 6 (2016)
       
  • An Unusual Case of Chronic Hepatitis
    • Authors: Kiran D. Shinde; Praveen kumar, D. Srinivas, Pravin Mathew, Dawood Kazia, Anil Kokkat, Prashanth Kanni, Manjunath Patil, Vishakha Khalde, Suraj Uppalapati, Mounika Kilari
      Abstract: Background: Drugs are an important cause of liver injury. Drugs account for 20–40% of all instances of fulminant hepatic failure. Drug induced hepatic injury is the more common reason cited for withdrawal of an appropriate drug. We are reporting a unusual case of chronic hepatitis.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.142
      Issue No: Vol. 6 (2016)
       
  • Utility of Tissue Elastography in Measuring Liver Iron Overload in
           
    • Authors: Kaivan Shah; Nirav Pipaliya, Prabha Sawant
      Abstract: Background and Aim: We undertook this study to establish whether tissue elastography (TE) can be used as an alternative to MRI T2* to predict the degree of iron overload and in turn, the degree of liver fibrosis in thalassemia major patients.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.141
      Issue No: Vol. 6 (2016)
       
  • Hepatobiliary Alterations in Ulcerative Colitis: A Report from a Tertiary
           Care Centre in Odisha
    • Authors: Pradeep Padhi; Jimmy Narayan, Preetam Nath, Prasant Parida, Kaibalya Dash, Sambit Behera, Suryakanta Parida, Girish Pati, Chitta Panda, Shivaram Singh
      Abstract: Background and Aim: Hepatobiliary manifestations are amongst the most common extraintestinal manifestations in chronic ulcerative colitis patients. There is paucity of data on hepatobiliary alterations in ulcerative colitis patients from India. The study was carried out to evaluate the hepatobiliary alterations in ulcerative colitis patients admitted to a tertiary care centre in Odisha.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.140
      Issue No: Vol. 6 (2016)
       
  • Enteral Parasites Detected by Fecal Exam, Colonoscopy, or Abdominal
           Imaging Studies in a Korean Health Checkup Center for 10 Years
    • Authors: Jong In Yang
      Abstract: Background and Aim: Detecting enteral parasitic infection can easily be done by simple fecal exam, and may also be aided by organ specific exams such as abdominal ultrasonography (US), computed tomography (CT), or colonoscopy. Enteral parasitic infection may be serious enough to contribute to the carcinogenesis considering that clonorchiasis is known carcinogen for cholagiocarcinoma. The aim of our study was to explore the status of enteral parasites detected by fecal exam in a Korean health checkup center for 10 years and to examine the efficacy of each organ specific exam for detecting enteral parasites.
      Citation: Journal of Clinical and Experimental Hepatology 6, (2016)
      PubDate: 2016-07
      DOI: 10.1016/j.jceh.2016.06.139
      Issue No: Vol. 6 (2016)
       
  • Acute on Chronic Liver Failure—What is in a
           ‘Definition’'
    • Authors: Anil C. Anand; Radha K. Dhiman
      Abstract: Acute on chronic liver failure (ACLF) is a recently recognized syndrome and its definition has been evolving over last two decades. Currently, there is no universal consensus about the definition as kind of cases being seen in the Western world appear to be somewhat different from those that are seen in Asia Pacific region. But every one agrees that definition of ACLF should include following components. (a) The status of pre-existing liver disease, (b) defining the acute insult that leads to rapid deterioration of liver status, (c) time frame during which the acute insult can lead to rapid deterioration, (d) the quantification and definition of liver failure status after deterioration, which will determine the severity of ACLF, and (e) prediction of prognosis after analyzing first four components in the short and long terms.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-20
      DOI: 10.1016/j.jceh.2016.08.011
       
  • Polymorphisms in UGT1A1 Gene Predispose South Indians to Pigmentous
           Gallstones
    • Authors: Vishnubhotla Venkata Ravikanth; Guduru Venkat Rao, Bale Govardhan, Mitnala Sasikala, Chivukula Subramanyam, H.V. Vivekananda Murthy, Siddapuram Siva Prasad, G. Deepika, Rebala Pradeep, Duvvuru Nageshwar Reddy
      Abstract: Pigmentous gallstones occur in South Indians despite significant higher levels of circulating cholesterol. This study was conducted to identify the biochemical and/or genetic causes for the formation of pigmentous gallstones in this ethnic group.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-19
      DOI: 10.1016/j.jceh.2016.08.004
       
  • High-Fructose Intake Impairs the Hepatic Hypolipidemic Effects of a
           High-Fat Fish-Oil Diet in C57BL/6 Mice
    • Authors: Joshua S. Wooten; Tayler N. Nick, Andrew Seija, Kaylee E. Poole, Kelsey B. Stout
      Abstract: Overnutrition of saturated fats and fructose is one of the major factors for the development of nonalcoholic fatty liver disease. Because omega-3 polyunsaturated fatty acids (n-3fa) have established lipid lowering properties, we tested the hypothesis that n-3fa prevents high-fat and fructose-induced fatty liver disease in mice.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-16
      DOI: 10.1016/j.jceh.2016.09.001
       
  • The Long Road from Obesity to Atherosclerosis via the Liver
    • Authors: Swastik Agrawal
      Abstract: J Hepatol. 2016;65(July (1)):95–102. http://dx.doi.org/10.1016/j.jhep.2016.02.023
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-15
      DOI: 10.1016/j.jceh.2016.08.014
       
  • Tackling the Hepatitis C Disease Burden in Punjab, India
    • Authors: Radha K. Dhiman; Sandeep Satsangi, Gagandeep S. Grover, Pankaj Puri
      Abstract: Hepatitis C virus (HCV) is a globally prevalent pathogen and is a major cause of healthcare burden in India. HCV poses a significant problem in the state of Punjab, India owing to the higher prevalence of risk factors like unsafe medical practices (including unsafe injections and dental procedures) and intravenous drug use. The reported prevalence of HCV in this part of the country was 5.2% in 2012, while a recent study has shown the prevalence to be 3.2% in 2016. Similar to the other geographic belts in India, genotype 3 predominates in the state of Punjab.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-15
      DOI: 10.1016/j.jceh.2016.09.005
       
  • Giant Intrahepatic Portal Vein Aneurysm: Leave it or Treat it'
    • Authors: Amit Shrivastava; Jagdeesh S. Rampal, D. Nageshwar Reddy
      Abstract: Portal vein aneurysm (PVA) is a rare vascular dilatation of the portal vein. It is a rare vascular anomaly representing less than 3% of all visceral aneurysms and is not well understood. Usually, PVA are incidental findings, are asymptomatic, and clinical symptoms are proportionally related to size. Patients present with nonspecific epigastric pain or gastrointestinal bleeding with underlying portal hypertension. PVA may be associated with various complications such as biliary tract compression, portal vein thrombosis/rupture, duodenal compression, gastrointestinal bleeding, and inferior vena cava obstruction.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-13
      DOI: 10.1016/j.jceh.2016.08.013
       
  • Role of Diffusion Weighted Imaging (DWI) for Hepatocellular Carcinoma
           (HCC) Detection and its Grading on 3T MRI: A Prospective Study
    • Authors: Shiva Shankar; Naveen Kalra, Anmol Bhatia, Radhika Srinivasan, Paramjeet Singh, Radha K. Dhiman, Niranjan Khandelwal, Yogesh Chawla
      Abstract: Limited studies have evaluated the role of diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) for histologically grading the hepatocellular carcinoma (HCC).
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-13
      DOI: 10.1016/j.jceh.2016.08.012
       
  • Comments: Indian National Association for Study of the Liver (INASL)
           Guidance for Antiviral Therapy against HCV Infection: Update 2016
    • Authors: Sanjay Hadigal
      Abstract: I read with interest the above mentioned article.1 With the entry of the Direct Acting Antivirals, having an Indian guidelines for the country's clinicians is of outmost importance.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-09
      DOI: 10.1016/j.jceh.2016.08.003
       
  • Cirrhotic Patients Have Worse Bowel Preparation at Screening Colonoscopy
           than Chronic Liver Disease Patients without Cirrhosis
    • Authors: Anika K. Anam; Kunal Karia, Arun B. Jesudian, Brian P. Bosworth
      Abstract: Cirrhosis has been shown in small studies to be a predictor of suboptimal bowel preparation at screening colonoscopy. It has yet to be established whether patients with chronic liver disease in the absence of cirrhosis experience equally poor colon cleansing. Intestinal dysmotility related to cirrhosis might impair bowel preparation in this population more than those with chronic liver disease without cirrhosis.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-09
      DOI: 10.1016/j.jceh.2016.08.009
       
  • Histological Evaluation of Non-alcoholic Fatty Liver Disease and Its
           Correlation with Different Noninvasive Scoring Systems with Special
           Reference to Fibrosis: A Single Center Experience
    • Authors: Mitali M. Rath; Manas K. Panigrahi, Kaumudee Pattnaik, Pallavi Bhuyan, Sanjib K. Kar, Bijay Misra, Debasis Misra, Chudamani Meher, Omprakash Agrawal, Jayshree Rath, Shivaram P. Singh
      Abstract: Although liver biopsy remains the gold standard for the diagnosis of non-alcoholic fatty liver disease [NAFLD], many non-invasive markers of liver fibrosis have recently been proposed and assessed as surrogates of liver biopsy.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-06
      DOI: 10.1016/j.jceh.2016.08.006
       
  • Rapid Onset of Fatal Lactic Acidosis Complicating Tenofovir Therapy in a
           Diabetic Patient with Cirrhosis: A Cautionary Tale
    • Authors: Ramesh Kumar; Shivani Agrawal
      Abstract: A nucleotide analogue (NA) has potential to cause mitochondrial (mt) toxicity which may lead to the development of lactic acidosis (LA).1 Tenofovir, a nucleotide analogue, induced LA is extremely rare because of its low affinity for mt DNA polymerase.2 We report a 45-year-old gentleman, with a background history of diabetes mellitus (DM) and hepatitis B virus related liver cirrhosis, who developed fatal LA after initiation of tenofovir. The patient had advanced cirrhosis with Model for End-stage Liver Disease score of 24, and he had not been on any anti-diabetic medication for 3 months.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-09-06
      DOI: 10.1016/j.jceh.2016.08.010
       
  • Multifocal Intrahepatic Artery Aneurysm with FDG-avid Thrombosis
           Simulating Metastasis: Report of a Rare Case
    • Authors: Xiaofei Zhang; Ashley E. Stueck, Sander Florman, Swan N. Thung, Sara Lewis
      Abstract: Hepatic artery aneurysm (HAA), although rare, represents a serious diagnostic and therapeutic challenge due to high rupture rate and associated mortality. Early detection and accurate diagnosis are essential for successful management. Here, we present an extremely rare case of multi-focal intrahepatic HAA with confined intrahepatic rupture and hypermetabolic activity at PET imaging, simulating metastasis of melanoma. A retrospective review found only two other HAA at our institution between 2000 and 2015, both of which involved the extrahepatic artery.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-08-27
      DOI: 10.1016/j.jceh.2016.08.002
       
  • Pharmacologic Treatment of Alcoholic Hepatitis: Examining Outcomes Based
           on Disease Severity Stratification
    • Authors: Ryan E. Owens; Heather S. Snyder, Jennifer D. Twilla, Sanjaya K. Satapathy
      Abstract: Maddrey discriminant function (MDF) score is a measure of disease prognosis in alcoholic hepatitis (AH) used to identify patients at highest risk of mortality and determine the need for initiation of pharmacologic treatment. The purpose of this study was to evaluate the effects of pharmacologic therapy for hospitalized AH patients as stratified by MDF score.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-08-01
      DOI: 10.1016/j.jceh.2016.07.003
       
  • Enucleation Sign: A Computed Tomographic Appearance of Ruptured
           Hepatocellular Carcinoma
    • Authors: Manphool Singhal; Upasna Sinha, Naveen Kalra, Ajay Duseja, Niranjan Khandelwal
      Abstract: Rupture of hepatocellular carcinoma (HCC) is a catastrophic complication, which carries high mortality. We report a case of spontaneous rupture of HCC, diagnosis of which was considered on clinical presentation and confirmed on computed tomographic (CT) scan. On CT scan, characteristic ‘enucleation sign’ was observed on arterial phase imaging, where a hypervascular peripheral mass showing central necrosis was seen protruding from liver surface with discontinuity of hepatic parenchyma associated with high attenuation ascites.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-06-06
      DOI: 10.1016/j.jceh.2016.05.004
       
  • Progressive Familial Intrahepatic Cholestasis (PFIC) in Indian Children:
           Clinical Spectrum and Outcome
    • Authors: Sajan Agarwal; Bikrant Bihari Lal, Dinesh Rawat, Archana Rastogi, Kishore G.S. Bharathy, Seema Alam
      Abstract: To study the clinical and laboratory profile of children with progressive familial intrahepatic cholestasis (PFIC) and evaluate their outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-06-04
      DOI: 10.1016/j.jceh.2016.05.003
       
  • Hepatocellular Carcinoma Presenting as Dyspnea at Rest due to Innumerable
           Lung Metastasis
    • Authors: Naveen Kumar; Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal
      Abstract: Hepatocellular carcinoma (HCC) the most common primary tumor of the liver usually develops in the setting of chronic liver disease. The presentation is usually due to worsening of chronic liver disease or being detected incidentally on imaging. Rarely metastasis to distant organ becomes the presentation. The authors describe a case of a 70-year-old woman who presented with dyspnea of 2 weeks duration. She was diagnosed as having HCC and extensive multiple pulmonary metastases. She was symptomatic only for the pulmonary metastasis with only 2 lesions in the liver.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-31
      DOI: 10.1016/j.jceh.2016.05.005
       
  • Iatrogenic Cushing Syndrome from Interaction Between Ritonavir and Oral
           Budesonide During Direct Acting Antiviral Hepatitis C Therapy
    • Authors: Sern Wei Yeoh
      Abstract: Direct acting antiviral (DAA) regimens containing ritonavir have been developed to treat hepatitis C, with fewer side effects than that by interferon-based regimens. However prescribers must be aware of drug–drug interactions. There are multiple reports of iatrogenic Cushing syndrome (CS) caused by ritonavir, when used to treat human immunodeficiency virus, increasing the bioavailability of exogenous steroids by inhibiting cytochrome p450 enzymes in the liver and gut wall and thus reducing steroid metabolism.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-31
      DOI: 10.1016/j.jceh.2016.05.006
       
  • Non-invasive Diagnosis of Oesophageal Varices Using Systemic Haemodynamic
           Measurements by Finometry: Comparison with Other Non-invasive Predictive
           Scores
    • Authors: Kara Rye; Gerri Mortimore, Andrew Austin, Jan Freeman
      Abstract: Cirrhosis and portal hypertension are characterised by a hyperdynamic circulation, which is independently associated with variceal size. Non-invasive techniques for measurement of systemic haemodynamics are now available.The aim of the study was to prospectively assess the accuracy of systemic haemodynamics measured non-invasively for the detection of oesophageal varices in cirrhotic patients as compared to other currently available non-invasive methods.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-05-20
      DOI: 10.1016/j.jceh.2016.05.001
       
  • Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using
           Proton Nuclear Magnetic Resonance Spectroscopy
    • Authors: Mohamed I.F. Shariff; Jin U. Kim, Nimzing G. Ladep, Mary M.E. Crossey, Larry K. Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen Ryder, Shaun Greer, I. Jane Cox, Roger Williams, Elaine Holmes, Kathryn Nash, Simon D. Taylor-Robinson
      Abstract: Discriminatory metabolic profiles have been described in urinary 1H nuclear magnetic resonance (NMR) spectroscopy studies of African patients with hepatocellular carcinoma (HCC). This study aimed to assess similarities in a UK cohort, where there is a greater etiological diversity.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-04-27
      DOI: 10.1016/j.jceh.2016.03.003
       
  • Honeycomb Cyst of the Liver
    • Authors: Sunil Taneja; Pramod Kumar, Ajay Duseja, Virendra Singh, Radha K. Dhiman, Yogesh Chawla
      Abstract: A 34-year-old female presented with pain in the abdomen for 5 months. The general physical and systemic examination was normal. Ultrasound of abdomen showed two well-defined exophytic multiloculated cystic lesion of size 8.4cm×7cm and 5cm×3.2cm in segment 2/4 and 8 of the liver. Radial endoscopic ultrasound was done to confirm the diagnosis of hydatid cyst, which showed two anechoic multiseptated honeycomb-shaped cysts in liver with daughter cysts and hydatid sand (Figure 1). Later the serology for IgG antibody for hydatidosis came positive in 1:1600 titres.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-19
      DOI: 10.1016/j.jceh.2016.03.001
       
  • Giant-cell Hepatitis—Rare Entity in Adults
    • Authors: Shiran Shetty; Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Vadakkepat Nirmala
      Abstract: Giant-cell hepatitis (GCH) is characterized by parenchymal inflammation with formation of large multinucleated hepatocytes in response to a variety of insults to the liver. Although it is commonly described in neonates, it rarely occurs in adults. Here we report a case of GCH because of herbal medicine intake.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-16
      DOI: 10.1016/j.jceh.2016.02.007
       
  • Delayed Severe Hemobilia Due to Bilio-venous Fistula After Percutaneous
           Transhepatic Biliary Drainage: Treatment With Covered Stent Placement
    • Authors: Kumble S. Madhusudhan; Nihar R. Dash, Adil Afsan, Shivanand Gamanagatti, Deep N. Srivastava, Arun K. Gupta
      Abstract: Biliovenous fistula occurs due to development of a communication between hepatic duct and portal vein branches and is a rare complication of percutaneous transhepatic biliary drainage (PTBD). Most of them are self-limiting and only occasionally they need interventional management. Placement of biliary stent graft is a viable option. We present here a case of a 56-year-old male with carcinoma of gall bladder presenting with hemodynamic shock due to severe hemobilia after PTBD and treated successfully by biliary covered stent placement.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-03-04
      DOI: 10.1016/j.jceh.2016.02.002
       
  • Hemodynamic Response to Carvedilol is Maintained for Long Periods and
           Leads to Better Clinical Outcome in Cirrhosis: A Prospective Study
    • Authors: Vijendra Kirnake; Anil Arora, Varun Gupta, Praveen Sharma, Vikas Singla, Naresh Bansal, Mohan Goyal, Romesh Chawlani, Ashish Kumar
      Abstract: Non-selective beta-blockers (NSBBs), e.g. propranolol, are recommended for prophylaxis of variceal bleeding in cirrhosis. Carvedilol, a newer NSBB with additional anti-α1-adrenergic activity, is superior to propranolol in reducing portal pressure. Repeated HVPG measurements are required to identify responders to NSBB. We aimed to determine whether a single-time HVPG measurement, using acute-hemodynamic-response-testing, is sufficient to predict long-term response to carvedilol, and whether these responders have better clinical outcome.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-02-06
      DOI: 10.1016/j.jceh.2016.01.004
       
  • Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate
           LX-2 Cells
    • Authors: Devaraj Ezhilarasan; Jonathan Evraerts, Sid Brice, Pedro Buc-Calderon, Sivanesan Karthikeyan, Etienne Sokal, Mustapha Najimi
      Abstract: Proliferation of hepatic stellate cells (HSCs) play pivotal role in the progression of hepatic fibrosis consequent to chronic liver injury. Silibinin (SBN), a flavonoid compound, has shown to possess cell cycle arresting potential against many actively proliferating cancers cell lines. The objective of this study was to evaluate the anti-proliferative and cell cycle arresting properties of SBN in rapidly proliferating human hepatic stellate LX-2 cell line.
      Citation: Journal of Clinical and Experimental Hepatology (2016)
      PubDate: 2016-01-29
      DOI: 10.1016/j.jceh.2016.01.002
       
 
 
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