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Journal Cover Archives of Pathology & Laboratory Medicine
  [SJR: 1.258]   [H-I: 80]   [17 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0003-9985 - ISSN (Online) 1543-2165
   Published by College of American Pathologists Homepage  [1 journal]
  • Metastatic Renal Cell Carcinoma to the Pancreas: A Review
    • Abstract: Clinically, secondary neoplasms affecting the pancreas are uncommon, accounting from 2% to 5% of all malignancies in the pancreas.1 The more common distant metastases affecting the pancreas include renal cell carcinoma, melanomas, colorectal carcinomas, lung carcinomas, breast carcinomas, and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Clinicopathologic Threshold of Acute Colorectal Graft-versus-Host Disease
    • Abstract: Graft-versus-host disease (GVHD) is a donor-derived immune response after bone marrow, stem cell, or cord blood cell transplantation that manifests clinically and histologically in the gastrointestinal (GI) tract, skin, and liver. In the appropriate clinical setting, colon biopsies are used to ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Variability in Testing for Antineutrophil Cytoplasmic Antibodies: A Survey
           of Participants in the College of American Pathologists Proficiency
           Testing Program
    • Abstract: Laboratory evaluation for the presence of antineutrophil cytoplasmic antibodies (ANCAs) is used diagnostically in the evaluation of patients suspected of having systemic vasculitis.1-4 The main utility in ANCA testing is for smallvessel vasculitides, including microscopic polyangiitis; eosinophilic ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • It's Our Turn: Implications for Pathology from the Institute of Medicine's
           Report on Diagnostic Error
    • Abstract: Fifteen years ago, the Institute of Medicine (IOM) issued a report entitled To Err Is Human: Building a Safer Health System.1 The major finding of this report is that errors in the care of patients results in tens of thousands of deaths annually in the United States. This report focused primarily ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Forging into the Future: Archives Continues to Grow
    • Abstract: In reviewing the 90 year history of the Archives of Pathology & Laboratory Medicine since its birth in 1926, one is struck by the forward thinking of many of its editorial board members over the decades. Not surprisingly innovations that were imaginative and novel at the time of their inception in ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Sarcomatoid Urothelial Carcinoma of the Bladder: Analysis of 28 Cases with
           Emphasis on Clinicopathologic Features and Markers of
           Epithelial-to-Mesenchymal Transition
    • Abstract: Urothelial carcinoma (UCa) is the most common type of bladder cancer in the United States, accounting for greater than 90% of reported bladder cancer cases each year.1 Numerous histologic variants of UCa have been described and several of these variants portend a more aggressive clinical course ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • College of American Pathologists Cancer Protocols: Optimizing Format for
           Accuracy and Efficiency
    • Abstract: Recent advances in technology and the significant increase in health care-related information have increased the complexity of the delivery of medical care, forcing providers to incorporate large amounts of data into their clinical activities. Health care practitioners continue to rely on memory ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Reviving the Hospital Autopsy
    • Abstract: To the Editor.-The observations of Stephen Geller, MD, on the current state of the hospital autopsy in the United States1 are very familiar to me, as my colleagues and I who are responsible for hospital autopsies have said similar things to each other for years. In the end, the decline in the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Neonatal Unit Hemolysis Rates from an Academic Medical Center: A Quality
           Improvement Project
    • Abstract: To the Editor.-The purpose of our study is to monitor the hemolysis rate in neonatal blood samples received in our laboratory. A common cause of sample rejection due to a preanalytic error is hemolysis.1 Hemolysis is the rupture of red blood cells, releasing hemoglobin and other intracellular ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Angiomyolipoma with Epithelial Cysts
    • Abstract: Angiomyolipomas (AMLs) are common, well-described mesenchymal neoplasms of the kidney and are composed of varying amounts of smooth muscle, thickwalled dysplastic blood vessels, and adipose tissue.1 A rare cystic variant of AML was initially described in 2 case series in 2006; it was termed ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Monitoring of the Clonal Fraction by Fluorescence in Situ Hybridization in
           Myelodysplastic Syndrome: Comparison with International Working Group
           Treatment Response Criteria
    • Abstract: The diagnosis of myelodysplastic syndrome (MDS) is based on morphologic criteria, which require cytopenia accompanied by dysplasia in more than 10% of nucleated bone marrow (BM) cells. Dysplasia represents a morphologic phenotype of neoplastic clonal cells harboring somatic mutations and/or ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Testing PD-1/PD-L1 Expression in Cancer Therapy: Pathologic Insights and
           Economic Sustainability
    • Abstract: To the Editor.-We read with considerable interest the 2 editorials written by Philip T. Cagle, MD, and Eric H. Bernicker, MD, in the November and December 2015 issues of the Archives of Pathology & Laboratory Medicine, entitled ''A New Immunotherapy Drug Creates a Watershed for the Surgical ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Role of Tetrasomy for the Diagnosis of Urothelial Carcinoma Using
           UroVysion Fluorescent in Situ Hybridization
    • Abstract: Bladder cancer is the fourth most common cancer in men in the United States, and most of these cases are urothelial carcinoma (UC). Because UC tends to recur and may behave aggressively, patients require close monitoring.1 The methods commonly used to monitor bladder cancer include cytology and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Practical Applications in Immunohistochemistry: Carcinomas of Unknown
           Primary Site
    • Abstract: It is estimated that approximately 4% of all patients with cancer present with carcinomas of unknown primary (CUPs), representing a higher incidence than known malignancies such as non-Hodgkin lymphoma or ovarian cancer.1 The identification of a primary site in such a setting has taken on ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Chorangiosis of Chorionic Villi: What Does It Really Mean'
    • Abstract: One of the morphologic features of chorionic villi is their vascularity, which can be evaluated for diagnostic purposes as the number of vascular profiles per chorionic villus, the normal values ranging from 2 to 6 per terminal villus1 and larger numbers defined as hypervascularity. Extreme villous ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Next-Generation Sequencing of Matched Primary and Metastatic Rectal
           Adenocarcinomas Demonstrates Minimal Mutation Gain and Concordance to
           Colonic Adenocarcinomas
    • Abstract: Colorectal carcinoma is the third most common cause of cancer death in males and females in the United States.1 The American Cancer Society estimates that 93 090 cases of colon cancer and 39 610 cases of rectal cancer are expected to occur in 2015.1 Currently, patients with rectal adenocarcinoma ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Validation of the Lung Subtyping Panel in Multiple Fresh-Frozen and
           Formalin-Fixed, Paraffin-Embedded Lung Tumor Gene Expression Data Sets
    • Abstract: Lung cancer is the leading cause of cancer death in the United States, and more than 220 000 new lung cancer cases are identified each year.1 It is a heterogeneous disease with subtypes determined by genetics and morphology (ie, small cell carcinoma, carcinoid, adenocarcinoma [ACA], and squamous ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Jun 2016 00:00:00 -040
       
  • Recent Updates on Neuroendocrine Tumors from the Gastrointestinal and
           Pancreatobiliary Tracts
    • Abstract: Neuroendocrine tumors (NETs) from the gastrointestinal (GI) and pancreatobiliary tracts are heterogeneous tumors with diverse biologic and clinical behaviors that vary according to the primary tumor origin, type of neuroendocrine cell, and pathologic features.1-4 The distribution patterns of NETs ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Molecular Subtypes of Colorectal Cancer and Their Clinicopathologic
           Features, with an Emphasis on the Serrated Neoplasia Pathway
    • Abstract: Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer-related death in the United States, regardless of sex. The incidence of CRC has decreased in both men and women in the United States since the mid 1980s.1-3 In South Korea, there was a rapid increase in ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic
           Features
    • Abstract: Breast angiosarcoma can occur as a primary form without a known precursor and as a secondary form associated with a history of radiation therapy or chronic lymphedema after axillary lymph node dissection for mammary carcinoma (Stewart-Treves syndrome). In the early 1980s, doctors began to be aware ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Jejunoileal Neuroendocrine Tumors Complicated by Intestinal Ischemic
           Necrosis Are Associated with Worse Overall Survival
    • Abstract: Jejunoileal neuroendocrine tumors (JINETs) are among the most common neuroendocrine tumors of the gut. They differ clinically from neuroendocrine tumors of the stomach, duodenum, appendix, and rectum because they usually present at an advanced stage, with metastases to the liver and/or mesenteric ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Immunohistochemistry for NF2, LATS1/2, and YAP/TAZ Fails to Separate
           Benign from Malignant Mesothelial Proliferations
    • Abstract: To the Editor.-The separation of benign from malignant mesothelial proliferations remains a difficult problem in diagnostic pathology. Recent molecular studies have demonstrated that mesotheliomas commonly show mutation or deletion of cyclin-dependent kinase inhibitor 2A (CDKN2A, p16) and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Traceability Assessment and Performance Evaluation of Results for
           Measurement of Abbott Clinical Chemistry Assays on 4 Chemistry Analyzers
    • Abstract: Clinical laboratories have pivotal roles in clinical decisions regarding the diagnosis, risk assessment, treatment, and monitoring of patients.1 Thus, the methods used for diagnostic measurements must be accurate, precise, specific, and comparable among laboratories. Otherwise, inadequate or ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • The 14th Spring Seminar of the Korean Pathologists Association of North
           America
    • Abstract: This Special Section is a compilation of the lectures on gastrointestinal and pancreaticobiliary pathology presented at the 14th annual spring seminar of the Korean Pathologists Association of North America (KOPANA). This seminar was held in conjunction with the 104th annual meeting of the United ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • You're on Social Media! So Now What'
    • Abstract: The value of social media for professionals, including physicians, is now well established.1 Particularly for pathologists, medical specialists relatively few in number, it can serve as a force multiplier in educating patients and families, colleagues, and policymakers about the pathologists' ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Liposclerosing Myxofibrous Tumor: A Review
    • Abstract: The term liposclerosing myxofibrous tumor (LSMFT), first introduced by Ragsdale and Sweet1 in 1986, is used to identify a benign fibro-osseous lesion with a significant predilection for the proximal femur.2,3 The tumors typically present in the fourth decade of life and show distinctive ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Clinical Aspects of Idiopathic Inflammatory Bowel Disease: A Review for
           Pathologists
    • Abstract: Clinical and pathologic features of idiopathic inflammatory bowel disease (IBD), that is, Crohn disease (CD) and ulcerative colitis (UC), have been extensively studied for almost a century. Also, during the last decade, the incidence and prevalence of IBD has increased in Asian countries. ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Eltrombopag: Investigation of Previously Reported Serum Discoloration and
           Negative Interference on a Total Bilirubin Diazo Method
    • Abstract: To the Editor.-In the September 2013 issue, Cardamone et al1 reported that serum samples from 4 patients receiv- ing 200 or 300 mg of eltrombopag (Promacta, GlaxoSmithKline, Research Triangle Park, North Carolina) in a clinical trial for treatment of acute myelogenous leukemia were deep brownish ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Precision Medicine in Gastrointestinal Pathology
    • Abstract: ''The game is afootSherlock Holmes1President Barack Obama officially opened the age of precision medicine in his 2015 State of the Union address.2,3 This new $215 million initiative envisions a volunteer cohort of 1 million Americans who will have comprehensive examination of their DNA (genomic), ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Tumoral versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract,
           Gallbladder, and Ampulla of Vater
    • Abstract: Adenoma is the prototype precursor lesion in carcinogenesis. The adenoma-carcinoma sequence is one of the well-characterized models of the carcinogenesis pathway. Through the adenoma-carcinoma sequence, many histopathologic and genetic alterations have been characterized in colorectal ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Practical Points in Gastric Pathology
    • Abstract: With the advancements in endoscopy as a diagnostic and therapeutic modality, we have encountered a myriad of gastric epithelial lesions in clinical practice, which has raised several challenges. First, infrequently encountered entities or histologic features might be unfamiliar and difficult to ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 May 2016 00:00:00 -040
       
  • Review of Telemicrobiology
    • Abstract: The role of informatics in the clinical microbiology laboratory is growing, which includes the practice of telemicrobiology.1 Telemicrobiology is the use of telepathology technologies within the subdiscipline of clinical microbiology. Telepathology allows a human interpreter to have access to a ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Atypical Fibroxanthoma
    • Abstract: Atypical fibroxanthoma (AFX) has been a topic for debate since the 1960s, when Helwig1 coined its present name. He later published in 1973 a study2 of 140 cases describing its pathologic features. Since then, advancements in immunohistochemistry have made it possible to exclude other similar ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Template for Reporting Results of Biomarker Testing of Specimens from
           Patients with Melanoma
    • Abstract: The College of American Pathologists offers these templates to assist pathologists in providing clinically useful and relevant information when reporting results of biomarker testing. The College regards the reporting elements in the templates as important elements of the biomarker test report, but ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Clinical and Cost Implications of Universal versus Locally Advanced-Stage
           and Advanced-Stage-Only Molecular Testing for Epidermal Growth Factor
           Receptor Mutations and Anaplastic Lymphoma Kinase Rearrangements in
           
    • Abstract: Targeted agents have been shown to prolong the survival of patients with locally advanced or advanced (metastatic) non-small cell lung carcinoma (NSCLC) whose tumors harbor specific genetic alterations.1,2 The College of American Pathologists (CAP)/International Association for the Study of Lung ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Impact of Recent Developments in Lung Cancer on the Practice of Pathology
    • Abstract: Landmark events in the field of lung cancer in the past year have the potential to significantly alter the practice of pathology. We briefly review 3 important milestones: (1) approval of payment for low-dose computed tomography (LDCT) screening for lung cancer, (2) publication of an extensively ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Programmed Death Ligand-1 Immunohistochemistry- A New Challenge for
           Pathologists: A Perspective from Members of the Pulmonary Pathology
           Society
    • Abstract: Programmed death receptor-1 (PD-1) is a type 1 membrane protein of the immunoglobulin superfamily1 that has an important role in restricting immune-mediated tissue damage secondary to inflammation and/or infection. This immunomodulatory receptor is expressed on the surface of T and B cells, natural ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Acute Lung Injury: A Clinical and Molecular Review
    • Abstract: First officially described in 1967,1 acute respiratory distress syndrome (ARDS) is a complex and cascading process developing from acute lung injury (ALI). It has multiple etiologies and often results in fulminant respiratory failure and death. Approximately 150 000 individuals receive a diagnosis ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • PD-L1 and Lung Cancer: The Era of Precision-Ish Medicine?
    • Abstract: For more than a decade, treatment discussions in lung cancer, predominantly in pulmonary adenocarcinoma, have been dominated by exciting developments in therapies targeting molecular alterations in particular pathways of cellular activation that render tumors vulnerable to attack. As these ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Pathology Residents Are Not ''Trainees''
    • Abstract: To the Editor.-A recent issue of CAP Today1 includes the article "More Than Half of Pathology Trainees in 2012 Were Women."Many years ago, Lotte Strauss, MD, a pioneering woman pathologist and a founder of the specialty of pediatric pathology, commented about Paul Klemperer, MD, her teacher and one ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • New Markers for Separating Benign from Malignant Mesothelial
           Proliferations: Are We There Yet?
    • Abstract: Whether a patient has a malignant mesothelioma or a benign mesothelial reaction is a distinction that is crucial to patient care and prognosis, but one which, on biopsy or effusion cytology specimens, is sometimes exceedingly difficult. The basic morphologic features that enable this separation ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Ribonucleic Acid in Situ Hybridization Is a More Sensitive Method Than
           Immunohistochemistry in Detection of Thyroid Transcription Factor 1 and
           Napsin A Expression in Lung Adenocarcinomas
    • Abstract: Lung cancer is the leading cancer death in the United States and worldwide.1 Adenocarcinoma (ACA) is currently the most common type of lung malignancy.2 Confirmation of a cancer diagnosis or a diagnosis of non-small cell carcinoma of the lung is no longer adequate for clinical management because ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Pathology Reports: A Second Look
    • Abstract: To the Editor.-Based in Hanover, New Hampshire, Hypertherm is a company that manufactures arc welders. Ray works on the assembly line-he adds thermal sensors. But he can't do so until he makes sure that his coworker Pete has installed the wiring correctly. Dupont's Service Center in Dover, New ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Programmed Death Ligand-1 Immunohistochemistry: Friend or Foe?
    • Abstract: Following successful trials and much enthusiasm among the oncology community, the introduction of anti- programmed death receptor-1 (PD-1) and anti-programmed death ligand-1 (PD-L1) immune checkpoint inhibitors into routine practice for the treatment of advanced stage non- small cell lung cancer ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Transbronchial Cryobiopsies in the Evaluation of Lung Allografts: Do the
           Benefits Outweigh the Risks?
    • Abstract: Transbronchial biopsy evaluation is the gold standard to assess lung allografts for rejection and to distinguish rejection from its clinical mimickers such as aspiration, infection, abnormal drug reaction, or recurrent disease. Morphologic findings of allograft rejection might be patchy, raising ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Ossifying Fibromyxoid Tumor: An Update
    • Abstract: Ossifying fibromyxoid tumor (OFMT) is a rare musculoskeletal tumor of borderline malignant potential, displaying an uncertain line of differentiation.1 Enzinger et al2 reported this unique soft tissue neoplasm, which presented as a well-circumscribed nodular mass in the subcutaneous tissues or ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Next-Generation Sequencing of a Cohort of Pulmonary Large Cell Carcinomas
           Reclassified by World Health Organization 2015 Criteria
    • Abstract: Specific diagnosis of lung cancer cell types is recommended because of recent advances in lung cancer therapy.1,2 This shift led to proposals to use immunostains to further classify lung cancers lacking routine histologic features and to minimize the diagnosis of non-small cell lung cancer (NSCLC) ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • The Pulmonary Pathology Society's Future: Busy and Bright
    • Abstract: In the first part of the Pulmonary Pathology Society (PPS) Special Section,1 I reminisced about the PPS's amazing first 2 decades. This second part of the PPS Special Section provides an opportunity to briefly consider the PPS's future. The society's next Biennial Meeting will be held in Chicago on ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Apr 2016 00:00:00 -040
       
  • Clinical Validation of Anyplex II HPV HR Detection Test for Cervical
           Cancer Screening in Korea
    • Abstract: Persistent infection with at least one of the high-risk carcinogenic human papillomavirus (HPV) types is the primary risk factor for the development of cervical cancer. Human papillomavirus is found in virtually all cases of cervical cancer and precursor lesions.1,2 Providing clear information ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Twenty Years of the Pulmonary Pathology Society
    • Abstract: The year 2015 marked the 20-year anniversary of the Pulmonary Pathology Society (PPS). It was founded in 1995, under the leadership of William Travis, MD (USA), with Thomas Colby, MD (USA); Samuel Hammar, MD (USA); Bruce Mackay, MD (USA); Helmut Popper, MD (Austria); and Osamu Matsubara, MD, PhD ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Lung Transplantation: The State of the Airways
    • Abstract: Lung transplantation has been practiced since the early 1980s after a moratorium by the US National Institutes of Health ended with the introduction of cyclosporine for use in clinical practice. Since then, lung transplantation has become an option for patients with very advanced lung diseases of ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Abstracts from the Pulmonary Pathology Society 2015 Biennial Meeting
    • Abstract: Liver Kinase B1 Protein Expression in Lung Adenocarcinomas Studied by Immunohistochemistry: Preliminary Results of a Clinicopathologic StudyA. Chander; R. Jawale; J. Mueller. Baystate Medical Center/Tufts University School of Medicine, Springfield, Massachusetts.Context: Thirty percent of sporadic ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Pulmonary Langerhans Cell Histiocytosis: An Update from the Pathologists'
           Perspective
    • Abstract: Langerhans cell histiocytosis (LCH) is a rare disorder that is characterized by nodules composed of a heterogeneous cell population including cells that exhibit the phenotype of Langerhans cells and mixed acute and chronic inflammatory cells. Langerhans cell histiocytosis can involve almost any ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Impact of a Rapid Blood Culture Assay for Gram-Positive Identification and
           Detection of Resistance Markers in a Pediatric Hospital
    • Abstract: Bloodstream infections (BSIs) are associated with significant health care cost and prolonged hospital stays.1,2 Rapid initiation of effective antimicrobial treatment is a mainstay of therapy because delay is associated with increased morbidity and mortality.3,4 The workup of pathogens in the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Performance in Measurement of Serum Cystatin C by Laboratories
           Participating in the College of American Pathologists 2014 CYS Survey/In
           Reply
    • Abstract: To the Editor.-We would like to comment on the article ''Performance in Measurement of Serum Cystatin C by Laboratories Participating in the College of American Pathologists 2014 CYS Survey'' reporting substantial method-specific biases for cystatin C measurements.1We believe the discrepant results ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Uterine Adenosarcoma
    • Abstract: In 1974, Clement and Scully1 reported a series of tumors of the female genital tract that were described as mixed tumors of the uterus, in which the stromal component has been malignant, but the epithelial elements, benign and proposed naming these tumors adenosarcoma. A subsequent study,2 in ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • The Archives of Pathology & Laboratory Medicine's Nonagintennial
    • Abstract: This year's celebration of the Archives of Pathology & Laboratory Medicine's 90th anniversary provides a superb opportunity to reflect upon its amazing history and to consider how far medicine has come in such a brief period of human history.The year 1926 was a culturally robust year, distinguished ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Update on Pulmonary Fibrosis: Not All Fibrosis Is Created Equally
    • Abstract: Surgical lung biopsies are often performed for the evaluation of suspected pulmonary fibrosis identified radiologically. There are 3 distinctive pathologic patterns of pulmonary fibrosis, including usual interstitial pneumonia (UIP), fibrotic nonspecific interstitial pneumonia (fNSIP), and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Ex Vivo Artifacts and Histopathologic Pitfalls in the Lung
    • Abstract: Normal lung histology including usual tissue artifacts is well described.1 Unfortunately, virtually all writings and images are concerned with ''static'' morphologic findings. Recently, attention has been focused on dynamic changes in the lung that cause a pitfall in the diagnosis of pulmonary ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Next-Generation Sequencing and Immunotherapy Biomarkers: A Medical
           Oncology Perspective
    • Abstract: It would not be an act of an optimistic oncologist's hyperbole to state that the explosion in genomic information and the development of immunotherapy agents have revolutionized the care of cancer patients, with more advances undoubtedly to continue to be realized in the next few years. However, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Non-Small Cell Lung Cancer, PD-L1, and the Pathologist
    • Abstract: Traditionally the treatment of advanced non-small cell lung cancer (NSCLC) was limited to radiotherapy, chemotherapy, or a combination of both, depending on tumor stage and patient fitness.1,2 In recent years, molecular targeted therapies have presented an alternative therapeutic approach for ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Kidney: A Rare and
           Lethal Entity
    • Abstract: Ewing sarcoma/primitive neuroectodermal tumor (ES/ PNET) is a group of rare, primitive, biologically aggressive tumors derived from the neuroectoderm. Although the tumor typically arises in the soft tissue and bones of children and young adults, it may rarely present as a tumor arising from the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Tue, 01 Mar 2016 00:00:00 -050
       
  • Mutation in BRAF and Other Members of the MAPK Pathway in Papillary
           Thyroid Carcinoma in the Pediatric Population
    • Abstract: Papillary thyroid carcinoma (PTC) is an uncommon tumor in the pediatric population. Despite having an excellent prognosis with long-term mortality rates of less than 1%,1,2 pediatric patients with PTC tend to present with advanced disease often with increased rates of extrathyroidal tumor ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Implications of the Updated 2013 American Society of Clinical
           Oncology/College of American Pathologists Guideline Recommendations on
           Human Epidermal Growth Factor Receptor 2 Gene Testing Using
           Immunohistochemistry and Fluorescence in Situ Hybridization for Breast
           Cancer
    • Abstract: The human epidermal growth factor receptor 2 oncogene (HER2/neu) is amplified in approximately 20% of human breast cancers,1 leading to overexpression of a 185-kDa glycoprotein with tyrosine kinase activity.2 Both HER2/neu amplification and overexpression result in an aggressive clinical phenotype ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Five Top Stories in Thyroid Pathology
    • Abstract: Thyroid disorders are among the most common endocrine abnormalities encountered in surgical pathology practice. In the category of nonneoplastic lesions, patients with Hashimoto thyroiditis (HT) often undergo surgical resection for investigation of a masslike lesion. A subset of fibrosing variant ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • A Comparison of the Roche Cobas HPV Test with the Hybrid Capture 2 Test
           for the Detection of High-Risk Human Papillomavirus Genotypes
    • Abstract: The causal relationship between human papillomavirus (HPV) and cervical cancer and its precursors has been well established.1 To date, more than 150 HPV genotypes have been identified, and approximately 60 of them are known to infect the human genital tract including the uterine cervix.2 Among the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • DNA Yield from Tissue Samples in Surgical Pathology and Minimum Tissue
           Requirements for Molecular Testing
    • Abstract: Molecular oncology assays are used increasingly to direct therapy for primary and metastatic tumors, and they can also provide important diagnostic and prognostic information.1,2 Assays performed on solid tumors can require substantial amounts of DNA, sometimes as much as 1 lg for comprehensive ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Ebola Virus Preparedness: Emerging Viruses and Ethics in Laboratory
           Medicine
    • Abstract: As of March 11, 2015, the West African Ebola virus (EV) outbreak, which began in March 2014 had involved 24 282 reported cases and 9976 reported deaths; because the outbreak is occurring in some of the poorest and leastaccessible parts of the world, the actual numbers are likely to be significantly ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Archives of Pathology & Laboratory Medicine: Pioneering Spirit
           Continues after 90 Years
    • Abstract: In its 90 years of existence, the Archives of Pathology & Laboratory Medicine has undergone many modifications as an ever-evolving instrument for the dissemination of medical knowledge, induding many that were made during the past decade under the current editorial board. This year of our ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Test Cancellation: A College of American Pathologists Q-Probes Study
    • Abstract: Alaboratory test may be canceled for a variety of reasons after a specimen has been collected from the patient and received in the laboratory. Test cancellation may affect patient care by delaying the reporting of clinically important test results, if the specimen must be recollected.1-4 ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Follicular Dendritic Cell Sarcoma
    • Abstract: Follicular dendritic cell sarcoma (FDCS) was first described in 1986 by Monda et al,1 in a series of 4 cases with initial presentation of unilateral cervical adenopathy, as a nonlymphomatous primary lymph node malignancy with features suggesting dendritic reticulum cell origin. Follicular dendritic ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Assessment of the Utility of PAX8 Immunohistochemical Stain in Diagnosing
           Endocervical Glandular Lesions
    • Abstract: The PAX8 gene is a member of the paired-box family of genes that is important in embryogenesis of the thyroid, Müllerian tract, and kidneys.1 Previous studies have shown that PAX8 is expressed in thyroid, renal, and Müllerian tumors, such as ovarian and endometrial malignancies. PAX8 was reported ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • False Breast Margins: Human Factors/In Reply
    • Abstract: To the Editor.-Because I do not recall a journal discussion of the causes for false-positive or false-negative margins, the Schnitt et al1 article has me concerned. A standard text mentions some factors for that concern.2 In this age in which we presume that bestpractices (with internationally ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Point-of-Care Glucose Critical Values: A Q-Probes Study Involving 50
           Health Care Facilities and 2349 Critical Results
    • Abstract: The concept for rapid communication of '' life-threatening'' laboratory results was first described in 1972 by Lundberg.1 Since then, notification of critical test results has been established as an important patient safety goal, integrated into medical practice, and required for hospital and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Reference Method and Reference Material Are Necessary Tools to Reveal the
           Variability of Cystatin C Assays
    • Abstract: To the Editor.-We read with great interest the article by Eckfeldt et al1 regarding the accuracy of cystatin C (cystC) measurements in the College of American Pathologists 2014 survey. In 2008, The French Society of Clinical Biology (SFBC) conducted a multicentric evaluation of isotope dilution ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Application of the 1,3-[Beta]-D-Glucan (Fungitell) Assay in the Diagnosis
           of Invasive Fungal Infections
    • Abstract: With new advances in organ transplantation,1 therapy for hematologic malignancies,2 and immunomodulation therapy,3 the number of patients who are immunocompromised and at increased risk for life-threatening fungal infections is worrisome.4 Early and appropriate treatment is essential,5 which ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Feb 2016 00:00:00 -050
       
  • Ninety Years of Supporting the Practice of Pathology and Laboratory
           Medicine: Archives Celebrates Milestone Anniversary
    • Abstract: This month, January 2016, we celebrate the 90th anniversary of the Archives of Pathology & Laboratory Medicine. First published in January 1926 as a specialty journal of the American Medical Association, the ARCHIVES is one of the oldest continuously published pathology journals in the United ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Computational Pathology: A Path Ahead
    • Abstract: The recent growth of electronic health records ([EHRs]; including the massive amounts of information in clinical laboratory information systems), coupled with powerful new computational approaches for analyzing large data sets, has created an opportunity to establish a new discipline within ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Villous Adenoma of the Urinary Bladder: A Brief Review of the Literature
    • Abstract: More than 90% of bladder neoplasms arise from the urothelial lining. Villous differentiation of the urothelial cells and villous adenomas of the urinary tract are exceedingly rare. They can occur in the urinary bladder, urachus, renal pelvis, ureter, and urethra. We found 2 case series and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Duodenal Gangliocytic Paraganglioma with Lymph Node Metastasis
    • Abstract: Gangliocytic paraganglioma (GP) is characterized by the triphasic cellular differentiation; epithelioid neuroendocrine cells, spindle cells with Schwann cell-like differentiation, and ganglion cells comprise the tumor. Gangliocytic paraganglioma is a rare tumor that usually occurs in the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Trends in Cervical Cytology Screening and Reporting Practices: Results
           from the College of American Pathologists 2011 PAP Education Supplemental
           Questionnaire
    • Abstract: Cervical cytology has been the focal point for cytology innovation for the past 20 years, beginning with the adoption of the 1991 Bethesda System (TBS) for reporting cervicovaginal cytology. Since then, the practice of processing, screening, interpreting, and reporting Papanicolaou (Pap) tests has ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Validation of the IHC4 Breast Cancer Prognostic Algorithm Using Multiple
           Approaches on the Multinational TEAM Clinical Trial
    • Abstract: With progressively improving outcomes, particularly for patients with estrogen receptor (ER)-positive early breast cancers, personalized risk stratification to direct appropriate therapy is increasingly important. Multiple approaches to the assessment of residual risk exist, and successful breast ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Diagnostic Error in Anatomic Pathology/In Reply
    • Abstract: To the Editor.-Diagnostic error has only recently received significant attention. The seminal Institute of Medicine report, ToErrIsHuman (2000),1 made only a couple of mentions of error. Since then, there has been a tangible focus on this issue, including, for example, the establishment of the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Interpretive Diagnostic Error Reduction in Surgical Pathology and
           Cytology: Guideline from the College of American Pathologists Pathology
           and Laboratory Quality Center and the Association of Directors of Anatomic
           and Surgical Pathology
    • Abstract: The test cycle in surgical pathology and cytology is similar to the test cycle of other laboratory tests.1-4 It is composed of the preanalytic, analytic, and postanalytic phases. The preanalytic and postanalytic phases are very similar to tests in the clinical laboratory. The preanalytic phase is ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Reappraisal of Serosal Invasion in Patients with T3 Colorectal Cancer by
           Elastic Stain: Clinicopathologic Study of 139 Surgical Cases with Special
           Reference to Peritoneal Elastic Lamina Invasion
    • Abstract: According to the World Health Organization classification of malignant tumors, pathologic stage pT3 colorectal cancer (CRC) is defined as a cancer invading through the muscularis propria into pericolorectal tissues, whereas pT4 CRC is defined as a cancer penetrating to the surface of visceral ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Diagnosis of Acute Myocardial Infarction in Hemodialysis Patients with
           High-Sensitivity Cardiac Troponin T Assay
    • Abstract: The most common cause of death among hemodialysis (HD) patients is cardiac death-predominantly acute myocardial infarction (AMI), which accounts for approximately 50% of all deaths.1 Rapid and accurate diagnosis of AMI is an urgent clinical need, as delays increase the risk of mortality.2,3 Delayed ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • A Comparative Study between Smartphone-Based Microscopy and Conventional
           Light Microscopy in 1021 Dermatopathology Specimens
    • Abstract: Dermatologic disease accounts for substantial global morbidity and is a leading cause of nonfatal disability. It is the fourth leading cause of nonfatal global disease burden.1,2 Skin conditions are responsible for an estimated 582 to 609 disability-adjusted-life-years (a measure of disease burden ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • More on Evidence-Based Medicine
    • Abstract: To the Editor.-Marchevsky and Wick1 recently (March 2015 issue of the ARCHIVES) provided a review of evidence-based medicine (EBM) as it applies to pathology. They summarize how to evaluate the literature more critically by reading it more critically. We wholeheartedly concur although we would add ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Respiratory Cytology-Current Trends Including Endobronchial
           Ultrasound-Guided Biopsy and Electromagnetic Navigational Bronchoscopy:
           Analysis of Data from a 2013 Supplemental Survey of Participants in the
           College of American Pathologists Interlaboratory Comparison Program in
           Nongynecologic Cytology
    • Abstract: The Cytopathology Committee (CC) of the College of American Pathologists (CAP) creates questionnaires and conducts surveys that are designed to assess current cytology laboratory practices. Early surveys from the CAP CC focused on adequacy and terminology in cervicovaginal cytology and on ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
  • Common Data Elements for Muscle Biopsy Reporting
    • Abstract: The muscle biopsy is an essential, and frequently used, diagnostic tool in the evaluation of pediatric and adult neuromuscular disorders, but its usefulness may be limited by poor communication from ordering clinicians or by incomplete reporting of pathologic findings on the biopsy report.1,2 The ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Fri, 01 Jan 2016 00:00:00 -050
       
 
 
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