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Journal Cover   Archives of Pathology & Laboratory Medicine
  [SJR: 1.258]   [H-I: 80]   [11 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0003-9985 - ISSN (Online) 1543-2165
   Published by College of American Pathologists Homepage  [1 journal]
  • The Essential Role of Pathologists in Health Care and Health Policy
    • Abstract: In the June2011 editionof CAPToday,then-College of American Pathologists (CAP) President Stephen N. Bauer, MD, authored an article titled ''50 Ways to Leave the Basement1 In addition to challenging pathologists and laboratory professionals to redefine pathology for our clinical colleagues, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Significance of Proximal Margin Involvement in Low-Grade Appendiceal
           Mucinous Neoplasms
    • Abstract: * Context. - Appendiceal adenomas and low-grade appendiceal mucinous neoplasms (LAMNs) confined to the appendix are cured by appendectomy. However, involvement of the proximal margin raises concern for residual disease. Some patients with a positive margin at appendectomy undergo cecal resection to ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Conversion, Correction, and International Scale Standardization: Results
           
    • Abstract: * Context. - Monitoring BCR-ABL1 expression levels relative to clinically validated response criteria on the International Scale (IS) is vital in the optimal management of patients with chronic myeloid leukemia, yet significant variability remains across laboratories worldwide.Objective.-To assess ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Biomarker Testing in Non-Small Cell Lung Cancer: A Clinician's Perspective
    • Abstract: In the 50 years since Stanley Cohen discovered the epidermal growth factor receptor (EGFR), the importance of mutations in driving malignant transformation and the ability to target them with small molecule tyrosine kinase inhibitors (TKIs) has helped expand the field of cancer therapeutics from ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Diagnostic Utility of PHOX2B in Primary and Treated Neuroblastoma and in
           Neuroblastoma Metastatic to the Bone Marrow
    • Abstract: * Context. - Neuroblastoma (NB) is the most common extracranial tumor of childhood. Although most cases have a distinctive histology, a subset of primitive cases require immunohistochemical studies to distinguish them from other small round blue cell tumors of childhood. Immunohistochemistry is ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Biomarkers and Oncology: The Path Forward to a Learning Health System
    • Abstract: Understanding what we mean by learning and how to accelerate learning is among the great challenges facing oncology. We are tasked to develop more sophisticated models of tumor biology and to learn how to apply tumor and host molecular profiles to direct treatment of patients with cancer. To ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • A New Ever-Evolving Paradigm
    • Abstract: Cancer biomarker testing is now a mainstay of 21st century pathology practice, embracing the pathologist's role in patient selection for specific targeted therapies. Pathologists, oncologists, and others require direction in adapting to this new ever-evolving paradigm.The Department of Pathology ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • The 2015 Physician Quality Reporting System Reflects Pathologists' Role in
           Lung Cancer Biomarker Testing
    • Abstract: It iswidelyrecognizedthatthepathologisthastheprimary role in determining which patients with lung cancer receive predictive biomarker testing based on cell type diagnosis and in selecting the tissue to be tested.1,2 In addition to selection for predictive biomarker testing for targeted molecular ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Low-Grade Fibromatosis-Like Spindle Cell Carcinoma of the Breast
    • Abstract: * Low-grade fibromatosis-like spindle cell carcinoma is a rare tumor in the breast, and represents a variant of the very heterogeneous group of metaplastic carcinomas of the breast. These tumors warrant distinction because of their resemblance to pure fibromatosis, their propensity for local ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • A Triple Stain of Reticulin, Glypican-3, and Glutamine Synthetase: A
           Useful Aid in the Diagnosis of Liver Lesions
    • Abstract: * Context.-The correct histologic diagnosis of mass lesions of the liver can be difficult, especially in biopsy samples. Reticulin, glypican-3, and glutamine synthetase are stains that can help distinguish hepatocellular carcinoma, hepatic adenoma, and focal nodular hyperplasia.Objective.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • A Newly Developed Mouse Monoclonal SOX10 Antibody Is a Highly Sensitive
           and Specific Marker for Malignant Melanoma, Including Spindle Cell and
           Desmoplastic Melanomas
    • Abstract: * Context.- Recent immunohistochemical studies have demonstrated Sry-related HMG-Box gene 10 (SOX10) expression in malignant melanomas, malignant peripheral nerve sheath tumors, a subset of breast carcinomas, and gliomas. SOX10 has shown important clinical utility in its ability to detect ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • College of American Pathologists' Laboratory Standards for Next-Generation
           Sequencing Clinical Tests
    • Abstract: * Context . - The higher throughput and lower per-base cost of next-generation sequencing (NGS) as compared to Sanger sequencing has led to its rapid adoption in clinical testing. The number of laboratories offering NGS-based tests has also grown considerably in the past few years, despite the fact ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Proteomic Analysis of Oral Cavity Squamous Cell Carcinoma Specimens
           Identifies Patient Outcome-Associated Proteins
    • Abstract: * Context.-Global proteomic analysis of oral cavity squamous cell carcinoma was performed to identify changes that reflect patient outcomes.Objectives.-To identify differentially expressed proteins associated with patient outcomes and to explore the use of imaging mass spectrometry as a clinical ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Biomarkers in Lung Adenocarcinoma: A Decade of Progress
    • Abstract: * Context. - The analysis of molecular biomarkers in lung adenocarcinoma (ACA) is now a central component of pathologic diagnosis and oncologic care. The identification of an EGFR mutation or ALK rearrangement in advanced-stage lung ACA will dictate a change in first-line treatment from standard ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Select Biomarkers for Tumors of the Gastrointestinal Tract: Present and
           Future
    • Abstract: * Context.- Advances in molecular biomarkers of the gastrointestinal tract have contributed to a decline in the incidence of and mortality from diseases of the gastrointestinal tract. The discovery and clinical validation of new biomarkers are important to personalized cancer therapy, and numerous ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Validation of a Next-Generation-Sequencing Cancer Panel for Use in the
           Clinical Laboratory
    • Abstract: * Context. - Next-generation sequencing allows for highthroughput processing and sensitive variant detection in multiple genes from small samples. For many diseases, including cancer, a comprehensive mutational profile of a targeted list of genes can be used to simultaneously inform patient care, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Respiratory Bronchiolitis with Fibrosis-Interstitial Lung Disease: A New
           Form of Smoking-Induced Interstitial Lung Disease
    • Abstract: The recent pathology literature has described a new form of localized interstitial fibrosis associated with heavy cigarette smoking. This lesion has been referred to by various names, including respiratory bronchiolitis-intersti-tial lung disease with fibrosis,1 airspace enlargement with fibrosis,2 ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Utility of ADAMTS13 Assays in Diagnosing Thrombotic Thrombocytopenic
           Purpura/In Reply
    • Abstract: To the Editor.-Thrombotic thrombocytopenic purpura (TTP) is an uncommon disorder, classified as a thrombotic microangiopathy (TMA) based on clinical findings of hemolytic anemia, thrombocytopenia, neurologic symptoms, fever, and renal dysfunction. 1 Unfortunately, several other TMAs have similar ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Renal Dysplasia
    • Abstract: * Renal dysplasia is an aberrant developmental disease usually diagnosed during the perinatal and childhood years. Prevalence is estimated at 0.1% of infants (via ultrasound screening) and 4% of fetuses and infants (via autopsy study). Occurrences may be combined with abnormalities in the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • Nonspecific Reactivity of Polyclonal Napsin A Antibody in Mucinous
           Adenocarcinomas of Various Sites: A Word of Caution
    • Abstract: To the Editor.-Napsin A has become a well-established marker of lung adenocarcinoma that is widely used in pathology laboratories for the workup of carcinomas of unknown primary and for subtyping of poorly differentiated neoplasms. Many studies show that Napsin A detects a subset of lung ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Wed, 01 Apr 2015 00:00:00 -040
       
  • High Collagen I Gene Expression as an Independent Predictor of Adverse
           Renal Outcomes in Lupus Nephritis Patients with Preserved Renal Function
    • Abstract: * Context. - The deposition of extracellular matrix is a major pathogenic mechanism leading to fibrosis and progressive decline in renal function in patients with lupus nephritis (LN). Currently, available clinicopathologic features cannot predict renal outcome consistently.Objective.-To test that ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • The Master Diagnostic Anatomic Pathologist
    • Abstract: The American scholar Warren G. Bennis once said that e]xcellence is a better teacher than mediocrity. The lessons of the ordinary are everywhere. Truly profound and original insights are to be found only in studying the exemplary 1 In efforts to enable current and future generations of anatomic ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Sudden Cardiac Death: A Modern Pathology Approach to Hypertrophic
           Cardiomyopathy
    • Abstract: * Hypertrophic cardiomyopathy is one of the most common causes of sudden cardiac death among young adults and adolescents. Unfortunately, the first manifestation of the condition may be sudden death during exertion, such as sporting activities. Other clinical symptoms include exertional dyspnea, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • The Pathology Residency Program of the Johns Hopkins University School of
           Medicine: A Model of Its Kind
    • Abstract: * Context.-The Department of Pathology of the Johns Hopkins University pioneered in the late 19th century the application of the scientific method to the study of medicine and fostered the development of residency training programs.Objective.-To trace the history of the Johns Hopkins Pathology ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Clear Cell Sarcoma-Like Tumor of the Gastrointestinal Tract: An Evolving
           Entity
    • Abstract: * Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is a rare malignant neoplasm that occurs in the wall of the small bowel, stomach, or large bowel, predominantly in young adults. It is an aggressive neoplasm that frequently presents with metastatic disease and has a high ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Bethesda System Reporting Rates for Conventional Papanicolaou Tests and
           Liquid-Based Cytology in a Large Chinese, College of American
           Pathologists-Certified Independent Medical Laboratory: Analysis of 1 394
           389 Papanicolaou Test Reports
    • Abstract: * Context. - Reports that use the Bethesda System categories for Chinese Papanicolaou test results are rare.Objective.-To document and analyze rates reported in the Bethesda System for conventional Papanicolaou tests and liquid-based cytology between 2007 and 2012 in China's largest College of ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Pathologists as Stewards of Laboratory Information
    • Abstract: * Just as electronic health records are transforming the practice of medicine and health care information management, practicing in the era of the electronic health record offers opportunities, if not imperatives, for pathologists to take on new and ''transformative'' professional and leadership ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Accreditation and Regulatory Implications of Electronic Health Records for
           Laboratory Reporting
    • Abstract: * The Clinical Laboratory Improvement Amendments of 1988 include strict regulations for reporting content, and it falls on the named director to ensure that this content is available to the caregiver. With the electronic health record serving as the conduit to the end user of the laboratory data, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Stand-Alone Laboratory Information Systems versus Laboratory Modules
           Incorporated in the Electronic Health Record
    • Abstract: * The increasing availability of laboratory information management modules within enterprise electronic health record solutions has resulted in some institutional administrators deciding which laboratory information system will be used to manage workflow within the laboratory, often with minimal ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Requisites to Strategic Planning
    • Abstract: Until a few years ago, the business environment for the practice of pathology was robust: stable third-party reimbursement, high revenues, content customers, and negligible competition. However, that environment is changing and the future does not look so favorable. Reduced federal and third-party ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Pathologists' Place in the Electronic Health Record Landscape
    • Abstract: * With growth spurred by recent federal efforts, electronic health records (EHRs) are transforming the practice of medicine and have important implications for pathologists, their laboratories, and the patients they serve. Beyond new EHR-related regulatory requirements, EHRs fundamentally alter the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Evidence-Based Pathology: Systematic Literature Reviews as the Basis for
           Guidelines and Best Practices
    • Abstract: * Context. - Evidence-based medicine has been proposed as a new paradigm for the identification and evaluation of medical information. Best available evidence or data are identified and used as the basis for the diagnosis and treatment of individual patients. Evidence-based pathology has adapted ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Anatomic Distribution of Sessile Serrated Adenoma/Polyp with and without
           Cytologic Dysplasia
    • Abstract: * Context.-Sessile serrated adenomas/polyps (SSA/Ps) have been increasingly studied during the last 10 years. However, their detailed anatomic distribution pattern has not been studied, especially given newer (broader) criteria for the diagnosis.Objectives.-To characterize the anatomic distribution ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Groove Pancreatitis: A Brief Review of a Diagnostic Challenge
    • Abstract: * Groove pancreatitis is an uncommon, yet well-described, type of focal chronic pancreatitis, affecting ''the groovethe area between the head of the pancreas, the duodenum, and the common bile duct. Men aged 40 to 50 years are most commonly affected, with a history of alcohol abuse frequently ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • An Algorithmic Approach to Sellar Region Masses
    • Abstract: * Context. - Most sellar region masses (85%-90%) are pituitary adenomas; however, other neoplasms or even inflammatory or cystic nonneoplastic lesions may occasionally be encountered in this location. A practical, non- electron-microscopically based approach is essential for the daily practice of ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Payment for Cancer Biomarker Testing
    • Abstract: Simply put, chemotherapy is poison that kills dividing cells. Medicare and other payers pay for it because, as cancers display unrestricted growth, frequently dividing cancer cells are killed by the poison-along with some normal cells, hence hair loss and other unpleasant but generally survivable ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous
           Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma
    • Abstract: * Context. - Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features.Objective.-To review the 2008 World Health ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Management of Laboratory Data and Information Exchange in the Electronic
           Health Record
    • Abstract: * In the era of the electronic health record, the success of laboratories and pathologists will depend on effective presentation and management of laboratory information, including test orders and results, and effective exchange of data between the laboratory information system and the electronic ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Red Blood Cell Transfusion Practices: A College of American Pathologists
           Q-Probes Study of Compliance with Audit Criteria in 128 Hospitals
    • Abstract: * Context. - Most information on compliance with audit criteria for red blood cell (RBC) transfusions comes from single institutions; few studies have compared practices among many hospitals.Objective.-To survey a cross-section of hospitals in 2008 for criteria and compliance with RBC transfusion ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Mar 2015 00:00:00 -050
       
  • Peripheral Lung Adenocarcinomas with KRAS Mutations Are More Likely to
           Invade Visceral Pleura
    • Abstract: * Context.-Kirsten-RAS (KRAS) mutations play an important role in the carcinogenesis of a subset of lung adenocarcinomas and are associated with poorer prognosis.Objective.-To investigate the relationship of KRAS mutation status to the histologic subtype of adenocarcinoma according to the recent ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Turnaround Time for Large or Complex Specimens in Surgical Pathology: A
           College of American Pathologists Q-Probes Study of 56 Institutions
    • Abstract: * Context.-Turnaround time (TAT) for large or complex surgical pathology specimens is an indicator of efficiency in anatomic pathology and may affect coordination of patient care.Objective.-To establish benchmarks for TAT and to identify practice characteristics that may influence ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Ordo Ab Chao: Framework for an Integrated Disease Report
    • Abstract: * Context.-The volume of information that must be assimilated to appropriately manage patients with complex or chronic disease can make this task difficult because of the number of data points, their variable temporal availability, and the fact that they may reside in different systems or even ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Pathologists and Medical Error Disclosure: Don't Wait for an Invitation
    • Abstract: T he recent insight of Gallagher and colleagues1 into the disclosure of medical error to patients is cogent; and their expertise on this sensitive topic is welcome. They emphasize as paramount "a patient's right to honest information shared with compassion about what happened to him or her. . ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Clinical Validation of Targeted Next-Generation Sequencing for Inherited
           Disorders
    • Abstract: * Context.-Although next-generation sequencing (NGS) can revolutionize molecular diagnostics, several hurdles remain in the implementation of this technology in clinical laboratories.Objectives.-To validate and implement an NGS panel for genetic diagnosis of more than 100 inherited diseases, such ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Four Decades of Necrotizing Sarcoid Granulomatosis: What Do We Know
           Now'
    • Abstract: * Context.-In the 4 decades since Dr Averill A. Liebow introduced necrotizing sarcoid granulomatosis, there have been publications of numerous cases, but its nature and possible relationship to classical and nodular sarcoidosis have been and remain controversial. Liebow introduced necrotizing ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Improving Positive Blood Culture Removal Time Significantly Decreases
           Total Processing Time
    • Abstract: * Context.-Timely processing of blood cultures with positive results, including Gram staining and notification of clinicians, is a critical function of the clinical microbiology laboratory. Analysis of processing time in our laboratory revealed opportunities to enhance workflow efficiency. We found ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Prior High-Risk Human Papillomavirus Testing and Papanicolaou Test Results
           of 70 Invasive Cervical Carcinomas Diagnosed in 2012: Results of a
           Retrospective Multicenter Study
    • Abstract: * Context.-Persistent high-risk human papillomavirus (hrHPV) infection is essential for the development of cervical cancer and its precursor lesions. High-risk HPV testing has a higher sensitivity than cytology does for detecting cervical epithelial lesions. However, a large study from a single ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Splenic Lymphangioma
    • Abstract: * Splenic lymphangioma is a rare malformation of the splenic lymphatic channels, mostly seen in children. It is characterized by the presence of cysts, resulting from increases in the size and number of thin-walled lymphatic vessels that are abnormally interconnected and dilated. The condition may ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Endocrine Manifestations of Von Hippel-Lindau Disease
    • Abstract: * von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by heterozygous mutations in the VHL tumor suppressor gene that is characterized by the occurrence of multiple endocrine and nonendocrine lesions. This review focuses on the endocrine manifestations of VHL disease. ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • A Cost-Effective Interdisciplinary Approach to Microbiologic Send-Out Test
           Use
    • Abstract: * Context.-Use of reference laboratories for selected laboratory testing (send-out tests) represents a significant source of laboratory costs. As the use of more complex molecular analyses becomes common in the United States, strategies to reduce costs in the clinical laboratory must evolve in ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • College of American Pathologists Advocacy: The Effort to Preserve Fair
           Payment
    • Abstract: M any physician specialties have experienced decreasing reimbursement relative to inflation during the past decade; pathology is among them.1,2 At such a time, members may wonder what the College of American Pathologists (CAP) is doing to help.The CAP has a carefully considered strategy to help ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Pulmonary Capillary Hemangiomatosis: A Rare Cause of Pulmonary
           Hypertension
    • Abstract: * Pulmonary capillary hemangiomatosis is a rare cause of pulmonary hypertension characterized by extensive proliferation of pulmonary capillaries within alveolar septae. Clinical presentation is nonspecific and includes dyspnea, cough, chest pain, and fatigue. Radiology shows diffuse centrilobular ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Systematic Review of the Effectiveness of Fine-Needle Aspiration And/or
           Core Needle Biopsy for Subclassifying Lymphoma
    • Abstract: * Context.-The World Health Organization system for lymphoma classification relies on histologic findings from excisional biopsies. In contradistinction to expert guidelines, practitioners increasingly rely on fine-needle aspiration cytology and core needle biopsies rather than excisional biopsies ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Performing Colonic Mast Cell Counts in Patients with Chronic Diarrhea of
           Unknown Etiology Has Limited Diagnostic Use
    • Abstract: * Context.-Mastocytic enterocolitis is a recently described entity defined by chronic diarrhea of unknown etiology and normal colon biopsy results with increased mast cells (MCs) seen on special stains. These patients may benefit from mast cell stabilizers; however, the clinical utility of MC ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Do Liquid-Based Preparations of Pulmonary Bronchial Brushing Specimens
           Perform Differently from Classically Prepared Cases for the Diagnosis of
           Malignancies' Observations from the College of American Pathologists
           Interlaboratory Comparison Program in Nongynecologic Cytology
    • Abstract: * Context.-Pulmonary bronchial brushing specimens can be processed by liquid-based or conventional methods. The ability to accurately diagnose a pulmonary malignancy with a liquid-based preparation (LBP) versus a conventional preparation may differ.Objective.-To compare the performance of LBPs of ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Undifferentiated Embryonal Sarcoma of the Liver: A Concise Review
    • Abstract: * Undifferentiated embryonal sarcoma of the liver is an aggressive mesenchymal tumor that occurs predominantly in children. Although this entity has been described for decades, its pathogenesis is still obscure. Its association with mesenchymal hamartoma has been well described on the basis of ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Clinical Performance of Hybrid Capture 2 Human Papillomavirus Testing for
           Recurrent High-Grade Cervical/Vaginal Intraepithelial Neoplasm in Patients
           with an ASC-US Papanicolaou Test Result during Long-Term Posttherapy
           Follow-Up Monitoring
    • Abstract: * Context.-Women who have been treated for high-grade cervical or vaginal intraepithelial neoplasia (CIN or VAIN) or invasive carcinoma are at risk for recurrent/persistent disease and require long-term monitoring. The role of human papillomavirus (HPV) testing in this setting is ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Challenges Posed to Pathologists in the Detection of KRAS Mutations in
           Colorectal Cancers
    • Abstract: * Context.-Detection of KRAS mutation is mandatory to predict response to anti-epidermal growth factor receptor monoclonal antibodies in patients with metastatic colorectal cancers.Objective.-To demonstrate challenges posed to pathologists in the clinical detection of KRAS mutations in colorectal ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Cervista HPV HR Test for Cervical Cancer Screening: A Comparative Study in
           the Catalonian Population
    • Abstract: * Context.-Almost all cervical cancers are related to the human papillomavirus (HPV). Future strategies for cervical cancer screening will be based on HPV detection. The Hybrid Capture 2 (HC2) test is currently the most widely used method to screen for HPV.Objective.-To test the performance of the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Differentiating Benign from Malignant Bone Marrow B-Cell Lymphoid
           Aggregates: A Statistical Analysis of Distinguishing Features
    • Abstract: * Context.-Lymphoid aggregates are seen in a minority of bone marrow biopsy specimens, and when present, their neoplastic nature is often apparent by morphologic evaluation. However, the distinction between benign and malignant aggregates can be a diagnostic challenge when there are multiple ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • MYB Is a Helpful Diagnostic Marker for Adenoid Cystic Carcinoma in
           Fine-Needle Aspiration Biopsy/In Reply
    • Abstract: To the Editor.-We read with great interest the recently published article by Hudson and Collins entitled "MYB Gene Abnormalities t(6;9) in Adenoid Cystic Carcinoma Fine-Needle Aspiration Biopsy Using Fluorescence In Situ Hybridization Using smears from fine-needle aspiration biopsy (FNAB) material, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Documenting the Cancer Journey
    • Abstract: D ata are useful only when they are transformed into knowledge. With the increasing complexity of chronic medical illness, of which cancer is a prime example, the value of medical data is realized when they are interpreted in clinical context and shared with the patient and the medical team ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Organizing Disparate, Seemingly Chaotic Data into a Meaningful and Useful
           Order
    • Abstract: I magine the physician of a century ago. The tools available to diagnose patient disease were limited, confined largely to the patient's history, physical diagnosis, and a few relatively elemental tests. And of course, collectively, our knowledge then of disease, causes, and cures was quite ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sun, 01 Feb 2015 00:00:00 -050
       
  • Application of Immunohistochemistry in Thyroid Pathology
    • Abstract: * Context.-Accurate classification of follicular-patterned thyroid lesions is not always an easy task on routine surgical hematoxylin-eosin-stained or cytologic fine- needle aspiration specimens. The diagnostic challenges are partially due to differential diagnostic criteria that are often subtle ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Utility of Immunohistochemistry in the Pancreatobiliary Tract
    • Abstract: * Context.-Immunohistochemistry has become a useful ancillary study in the identification and classification of pancreatic neoplasms. The diagnostic accuracy has been significantly improved because of the continuous discoveries of tumor-associated biomarkers and the development of effective ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Review and Updates of Immunohistochemistry in Selected Salivary Gland and
           Head and Neck Tumors
    • Abstract: * Context.-Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors.Objective.-To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors.Data Sources.-Literature review and authors' personal practice ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Immunohistochemistry in Dermatopathology
    • Abstract: * Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Next-Generation Companion Diagnostics: Promises, Challenges, and Solutions
    • Abstract: Companion diagnostics are in vitro clinical laboratory assays designed to predict the efficacy of a targeted cancer therapy through assessment of 1 or more biomarkers whose status in a patient's neoplasm assists in determining whether a drug may or may not be effective. Companion diagnostics can be ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • The Pulmonary Histopathology of Anti-KS Transfer RNA Synthetase Syndrome
    • Abstract: * Context.-The clinical spectrum of the antisynthetase syndromes (AS) has been poorly defined, although some frequently present with pulmonary manifestations. The anti-KS anti-asparaginyl-transfer RNA synthetase syndrome is one in which pulmonary interstitial lung disease is almost always present ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • The Utility of Immunohistochemistry in the Differential Diagnosis of
           Gynecologic Disorders
    • Abstract: * Context.-Immunohistochemistry has assumed an increasing role in the identification and characterization of gynecologic disorders including lesions with deceptively bland morphology, uncommon and underdiagnosed neoplasms, and neoplasms with specific genetic alterations associated with ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Neurogenic Polyps of the Gastrointestinal Tract: A Clinicopathologic
           
    • Abstract: Primary neurogenic gastrointestinal polyps are encountered relatively frequently in routine pathology practice. They encompass a variety of neoplastic entities with clinical, morphologic, and molecular features that reflect the diversity of neural elements within the gastrointestinal system. ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Proceedings of the African Pathologists Summit; March 22-23, 2013; Dakar,
           Senegal: A Summary
    • Abstract: * Context.-This report presents the proceedings of the African Pathologists Summit, held under the auspices of the African Organization for Research and Training in Cancer.Objectives.-To deliberate on the challenges and constraints of the practice of pathology in Sub-Saharan Africa and the avenues ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • An Update on the Application of Newly Described Immunohistochemical
           Markers in Soft Tissue Pathology
    • Abstract: * Context.-During the last 5 to 10 years, significant progress has been made in the molecular characterization of soft tissue tumors, predominantly with the identification of recurrent translocations or amplification of certain genes in different tumor types. Alongside this, translational efforts ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Application of Immunohistochemistry in Gastrointestinal and Liver
           Neoplasms: New Markers and Evolving Practice
    • Abstract: * Context.-Diagnosis of primary gastrointestinal and liver neoplasms is usually straightforward. Immunohistochemistry is most helpful to differentiate metastatic carcinomas with morphologic similarity and to resolve tumors of unknown origin. Recently, several new markers highly sensitive and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Thu, 01 Jan 2015 00:00:00 -050
       
  • Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and
           Mediastinal Cancers: A Review and Update
    • Abstract: * Context.-Immunohistochemistry has become an indispensable ancillary tool for the accurate classification of pleuropulmonary and mediastinal neoplasms necessary for therapeutic decisions and predicting prognostic outcome in the era of personalized medicine. Diagnostic accuracy has significantly ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Evolving Practices of Diagnostic Immunohistochemistry
    • Abstract: I t has been more than 6 years since the Archives of Pathology & Laboratory Medicine published the special issue on diagnostic immunohistochemistry (IHC) consisting of a series of review articles edited by Jaishree Jagirdar, MD, which was a great, concise, and yet comprehensive review and update on ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • The Diagnostic Accuracy of Percutaneous Renal Needle Core Biopsy and Its
           Potential Impact on the Clinical Management of Renal Cortical Neoplasms
    • Abstract: * Context.-While biopsies are now increasingly being performed for the diagnosis of renal cortical neoplasms, the influence of the rendered pathological diagnoses on the clinical management is only rarely documented.Objectives.-To report our experience with consecutively performed renal biopsies ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Muir-Torre Syndrome
    • Abstract: * Muir-Torre syndrome (MTS) is a rare autosomal- dominant genodermatosis characterized by sebaceous neoplasms and one or more visceral malignancies. Sebaceous tumors include sebaceous adenoma and carcinoma, which may be solitary or multiple. Visceral malignancies most often arise in the colorectum ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • New Immunohistochemistry for B-Cell Lymphoma and Hodgkin Lymphoma
    • Abstract: * Context.-B-cell non-Hodgkin lymphoma is a heterogeneous group of lymphoproliferative malignancies with different clinical behaviors and treatments. It is important to differentiate individual B-cell lymphoma to apply the best treatment and management. Morphology and immunohistochemistry are the ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • The Application of Immunohistochemical Biomarkers in Urologic Surgical
           Pathology
    • Abstract: * Context.-Tumors of the genitourinary tract can be diagnostically challenging, particularly in core biopsies and cystoscopic biopsies with limited material. Immunohistochemistry is a valuable tool to use when morphology alone is insufficient for diagnosis.Objectives.-To review tumors and benign ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Overview of Automated Immunohistochemistry
    • Abstract: * Context.-The increasing demand for immunohistochemistry for clinical diagnostics, in combination with an ongoing shortage of staff in the histology laboratory, has brought about a need for automation in immunohistochemistry. The current automated staining platforms vary significantly in their ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Standardization of Diagnostic Immunohistochemistry: Literature Review and
           Geisinger Experience
    • Abstract: * Context.-Immunohistochemistry has become an indispensable ancillary technique in anatomic pathology laboratories. Standardization of every step in preanalytic, analytic, and postanalytic phases is crucial to achieve reproducible and reliable immunohistochemistry test results.Objective.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Immunohistochemistry in Undifferentiated Neoplasm/Tumor of Uncertain
           Origin
    • Abstract: * Context.-Immunohistochemistry has become an indispensable ancillary study in the identification and classification of undifferentiated neoplasms/tumors of uncertain origin. The diagnostic accuracy has significantly improved because of the continuous discoveries of tissue-specific biomarkers and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Application of Immunohistochemistry in Breast Pathology: A Review and
           Update
    • Abstract: * Context.-Immunohistochemistry is a valuable tool in routine breast pathology, used for both diagnostic and prognostic parameters. The diagnostic immunomarkers are the scope of this review. Most breast lesions can be diagnosed on routine hematoxylin-eosin sections; however, in several scenarios, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • Comparison of Anti-Xa and Dilute Russell Viper Venom Time Assays in
           Quantifying Drug Levels in Patients on Therapeutic Doses of Rivaroxaban
    • Abstract: * Context.-Rivaroxaban is a new oral anticoagulant that functions as a direct anti-Xa inhibitor. Although routine monitoring is not required, measurement of plasma concentrations may be necessary in certain clinical situations. Routine coagulation assays, such as the prothrombin time and, to a ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Mon, 01 Dec 2014 00:00:00 -050
       
  • A Review of Preanalytical Factors Affecting Molecular, Protein, and
           Morphological Analysis of Formalin-Fixed, Paraffin-Embedded (FFPE) Tissue:
           How Well Do You Know Your FFPE Specimen'
    • Abstract: * Context.-Formalin fixation and paraffin embedding is a timeless, cost-efficient, and widely adopted method of preserving human tissue biospecimens that has resulted in a substantial reservoir of formalin-fixed, paraffin-embedded blocks that represent both the pathology and preanalytical handling ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • American Joint Committee on Cancer Staging and Clinicopathological
           High-Risk Predictors of Ocular Surface Squamous Neoplasia: A Study from a
           Tertiary Eye Center in India
    • Abstract: * Context.-Ocular surface squamous neoplasia (OSSN) is the most common tumor of conjunctival epithelium associated with risk of permanent visual impairment. It includes conjunctival intraepithelial neoplasia and squa- mous cell carcinoma. Although American Joint Committee on Cancer-TNM (AJCC-TNM) ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Stromal Tumor of Uncertain Malignant Potential of the Prostate
    • Abstract: * Stromal tumor of uncertain malignant potential (STUMP) of the prostate is a rare tumor with a variable and unpredictable clinical course. Many STUMPs are diagnosed incidentally and never progress, while others may invade locally and rapidly recur after surgical intervention, and yet others may ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Mining Formalin-Fixed, Paraffin-Embedded Tissues: A Wealth of Knowledge or
           Fool's Gold?
    • Abstract: The article by Bass et al titled, "A review of pre-analytical factors affecting molecular, protein, and morphological analysis of formalin-fixed, paraffin-embedded (FFPE) tissue: how well do you know your FFPE specimen found in this issue, is a very ambitious review of preanalytic factors and their ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Analysis of Addenda in Anatomic Pathology as a Quality Monitoring
           Initiative
    • Abstract: * Context.-Along with the integration of immunohisto-chemical markers and molecular techniques into routine practice, addenda in surgical pathology reporting have not only increased in frequency but also evolved to include prognostic and therapeutic information. Because of the lack of uniform ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • John G. Batsakis, MD (1929-2013): A Historical Perspective on His
           Contributions to Pathology
    • Abstract: On January 20, 2013, John G. Batsakis, MD, passed away peacefully at his home in Houston, Texas. We pay tribute to such a giant of a man for his significant and lasting contributions to the pathology field in general and to the head and neck subspecialty in particular. John was raised in upper ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Mitigating Overdiagnosis and Overtreatment in Breast Cancer: What Is the
           Role of the Pathologist?
    • Abstract: After decades of experience with breast cancer screening programs in the United States and other countries, recent attention has focused on balancing the benefits and harms of screening for breast cancer.1 In a Viewpoint article entitled "Overdiagnosis and Overtreatment in Cancer: An Opportunity ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Validating Whole-Slide Imaging for Consultation Diagnoses in Surgical
           Pathology
    • Abstract: Context.-The interpretation of scanned whole-slide images (WSI) offers some theoretical advantages for longdistance, consultative diagnosis in surgical pathology. Few WSI validation studies have focused on difficult consultation cases.Objective.-To test intraobserver variability of WSI ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Quantitative Multiplexed Detection of Common Pulmonary Fungal Pathogens by
           Labeled Primer Polymerase Chain Reaction
    • Abstract: Context.-Invasive fungal infections are an important cause of morbidity and mortality among immunocompromised patients.Objective.-To design and evaluate a multiplexed assay aimed at quantitative detection and differentiation of the 5 molds that are most commonly responsible for pulmonary ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Phyllodes Tumor of Vulva: A Brief Diagnostic Review
    • Abstract: * Phyllodes tumors of the vulva are rare proliferations that share morphologic similarities with breast neoplasms. Their histogenetic origin is elusive and may be associated with specialized mammary-like glands of the vulva. Because of their rarity, the clinical and pathologic features, ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Diagnostic Approach to Eosinophilic Renal Neoplasms
    • Abstract: * Context.-Eosinophilic renal neoplasms include a spectrum of solid and papillary tumors ranging from indolent benign oncocytoma to highly aggressive malignancies. Recognition of the correct nature of the tumor, especially in biopsy specimens, is paramount for patient management.Objective.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • The Influence of Free Hemoglobin and Bilirubin on Heparin Monitoring by
           Activated Partial Thromboplastin Time and Anti-Xa Assay
    • Abstract: * Context.-Elevated free hemoglobin (Hb) and bilirubi- nemia complicate extracorporeal membrane oxygenation and could affect unfractionated heparin (UH) therapy monitoring by anti-Xa assay and activated partial throm- boplastin time (aPTT).Objectives.-To compare in vitro response of anti-Xa and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Estrogen Receptor Expression Is High but Is of Lower Intensity in Tubular
           Carcinoma Than in Well-Differentiated Invasive Ductal Carcinoma
    • Abstract: * Context.-Tubular carcinoma (TC) is a rare, luminal A subtype of breast carcinoma with excellent prognosis, for which adjuvant chemotherapy is usually contraindicated.Objective.-To examine the levels of estrogen receptor (ER) and progesterone receptor expression in cases of TC and ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • HER2/neu Testing in Gastric Cancer by Immunohistochemistry: Assessment of
           Interlaboratory Variation
    • Abstract: * Context.-Immunohistochemical (IHC) testing for HER2/neu is becoming the standard of care for guiding adjuvant treatment of gastric carcinoma with trastuzumab.Objective.-To assess interlaboratory variation in IHC staining and interpretation across multiple laboratories.Design.-A tissue microarray ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
  • Documentation of Quality Control and Operator Training at Point-of-Care
           Testing: A College of American Pathologists Q-Probes Study of 106
           Institutions
    • Abstract: Context.-Operator training, quality control, and proper follow-up for out-of-range quality control (QC) events are crucial steps that must be adequately performed and documented to ensure excellent patient care and regulatory compliance.Objective.-To examine point-of-care testing (POCT) personnel ... (Publication: Archives of Pathology & Laboratory Medicine)
      PubDate: Sat, 01 Nov 2014 00:00:00 -040
       
 
 
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