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Archives of Pathology & Laboratory Medicine 
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ISSN (Print) 0003-9985 - ISSN (Online) 1543-2165
Published by College of American Pathologists
[1 journal]
[3 followers] Follow Subscription journalISSN (Print) 0003-9985 - ISSN (Online) 1543-2165
Published by College of American Pathologists
[1 journal]- Pretransfusion Testing Practices in North America, 2005-2010: An Analysis of the College of American Pathologists Interlaboratory Comparison Program J-Survey Data, 2005-2010
- Abstract: Context.-Data collection and analysis of the College of American Pathologists (CAP) Interlaboratory Comparison Program (Proficiency Testing) J-Survey results provide insights into North American pretransfusion compatibility testing practices and trends. Objectives.-To assess current North American ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Data collection and analysis of the College of American Pathologists (CAP) Interlaboratory Comparison Program (Proficiency Testing) J-Survey results provide insights into North American pretransfusion compatibility testing practices and trends. Objectives.-To assess current North American ... (Publication: Archives of Pathology & Laboratory Medicine)
- Lymphoproliferative Conditions of the Serosa
- Abstract: Context.-A diverse and complex variety of lymphoproliferative diseases may involve the serosa, with widely differing clinical outcomes encompassing a spectrum of benign and malignant conditions. Objective.-To review lymphoproliferative disease involving the serosa and to provide a practical ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-A diverse and complex variety of lymphoproliferative diseases may involve the serosa, with widely differing clinical outcomes encompassing a spectrum of benign and malignant conditions. Objective.-To review lymphoproliferative disease involving the serosa and to provide a practical ... (Publication: Archives of Pathology & Laboratory Medicine)
- Sverdlovsk Revisited: Pulmonary Pathology of Inhalational Anthrax Versus Anthraxlike Bacillus cereus Pneumonia/In Reply
- Abstract: To the Editor.-The case report of rapidly progressive, fatal pneumonia caused by Bacillus cereus producing anthrax lethal toxin and edema toxin represents a landmark achievement in pathology.1 The investigators' decisiveness and speed in applying a contemporary genome sequencing approach were ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: To the Editor.-The case report of rapidly progressive, fatal pneumonia caused by Bacillus cereus producing anthrax lethal toxin and edema toxin represents a landmark achievement in pathology.1 The investigators' decisiveness and speed in applying a contemporary genome sequencing approach were ... (Publication: Archives of Pathology & Laboratory Medicine)
- Mesothelioma Not Associated With Asbestos Exposure
- Abstract: Context.-Despite asbestos being identified as the single most important cause of malignant mesothelioma, the tumor is known to occur in only 10% to 20% of heavily exposed individuals. In addition, about 20% of the patients have no history of asbestos exposure even after detailed assessment. ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Despite asbestos being identified as the single most important cause of malignant mesothelioma, the tumor is known to occur in only 10% to 20% of heavily exposed individuals. In addition, about 20% of the patients have no history of asbestos exposure even after detailed assessment. ... (Publication: Archives of Pathology & Laboratory Medicine)
- Immunohistochemistry and Molecular Diagnostics of Pleural Malignant Mesothelioma
- Abstract: Context.-The pathologic approach to pleural-based lesions is stepwise and uses morphologic assessment, correlated with clinical and imaging data supplemented by immunohistochemistry (IHC), and more recently, molecular tests, as an aid for 2 main diagnostic problems: malignant mesothelioma (MM) ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-The pathologic approach to pleural-based lesions is stepwise and uses morphologic assessment, correlated with clinical and imaging data supplemented by immunohistochemistry (IHC), and more recently, molecular tests, as an aid for 2 main diagnostic problems: malignant mesothelioma (MM) ... (Publication: Archives of Pathology & Laboratory Medicine)
- Molecular Changes in Mesothelioma With an Impact on Prognosis and Treatment
- Abstract: Context.-In recent decades, research on malignant pleural mesothelioma (MPM) has been developed to improve patients' outcomes by increasing the level of confidence in MPM diagnosis and prognosis. Objective.-To summarize data on genetic and epigenetic abnormalities in MPM that may be of interest for ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-In recent decades, research on malignant pleural mesothelioma (MPM) has been developed to improve patients' outcomes by increasing the level of confidence in MPM diagnosis and prognosis. Objective.-To summarize data on genetic and epigenetic abnormalities in MPM that may be of interest for ... (Publication: Archives of Pathology & Laboratory Medicine)
- CORRECTION
- Abstract: The first name of Lindsay Bonner Hardy, MD, was incorrectly shown as Linday in the byline of an article that appeared in the January 2012 issue (Idowu MO, Hardy LB, Souers RJ, Nakhleh RE. Pathologic Diagnostic Correlation With Breast Imaging Findings: A College of American Pathologists Q-Probes ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: The first name of Lindsay Bonner Hardy, MD, was incorrectly shown as Linday in the byline of an article that appeared in the January 2012 issue (Idowu MO, Hardy LB, Souers RJ, Nakhleh RE. Pathologic Diagnostic Correlation With Breast Imaging Findings: A College of American Pathologists Q-Probes ... (Publication: Archives of Pathology & Laboratory Medicine)
- Metastatic Crohn Disease: A Rare Cutaneous Entity
- Abstract: Metastatic Crohn disease is a rare cutaneous disorder characterized by noncaseating, granulomatous skin lesions present at sites anatomically separate from the gastrointestinal tract. It is the least common dermatologic manifestation of Crohn disease, and the differential diagnosis includes ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Metastatic Crohn disease is a rare cutaneous disorder characterized by noncaseating, granulomatous skin lesions present at sites anatomically separate from the gastrointestinal tract. It is the least common dermatologic manifestation of Crohn disease, and the differential diagnosis includes ... (Publication: Archives of Pathology & Laboratory Medicine)
- Human Immunodeficiency Virus-Related Gastrointestinal Pathology: A Southern Africa Perspective With Review of the Literature (Part 2: Neoplasms and Noninfectious Disorders)
- Abstract: Context.-Human immunodeficiency virus (HIV) infection is rife in sub-Saharan Africa and in southern Africa in particular. Despite the increasing availability of antiretroviral therapy in this region, HIV-associated neoplasms remain common and frequently involve the gastrointestinal tract, which may ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Human immunodeficiency virus (HIV) infection is rife in sub-Saharan Africa and in southern Africa in particular. Despite the increasing availability of antiretroviral therapy in this region, HIV-associated neoplasms remain common and frequently involve the gastrointestinal tract, which may ... (Publication: Archives of Pathology & Laboratory Medicine)
- Signet-Ring Cell Melanoma of the Gastroesophageal Junction: A Case Report and Literature Review
- Abstract: We report the first case, to our knowledge, of a possible primary, signet-ring cell melanoma of the gastroesophageal junction. The mass was initially diagnosed as an invasive, poorly differentiated carcinoma; however, on further review and immunohistochemical workup, the diagnosis of signetring ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: We report the first case, to our knowledge, of a possible primary, signet-ring cell melanoma of the gastroesophageal junction. The mass was initially diagnosed as an invasive, poorly differentiated carcinoma; however, on further review and immunohistochemical workup, the diagnosis of signetring ... (Publication: Archives of Pathology & Laboratory Medicine)
- Proteomics'/In Reply
- Abstract: To the Editor.-We write with regard to the recent article in the ARCHIVES entitled "Comparison of Formalin- Free Tissue Fixatives: A Proteomic Study Testing Their Application for Routine Pathology and Research," 1 which is 1 of 2 articles that have recently been published by the University of Graz ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: To the Editor.-We write with regard to the recent article in the ARCHIVES entitled "Comparison of Formalin- Free Tissue Fixatives: A Proteomic Study Testing Their Application for Routine Pathology and Research," 1 which is 1 of 2 articles that have recently been published by the University of Graz ... (Publication: Archives of Pathology & Laboratory Medicine)
- When Melanoma Is Negative for S100: Diagnostic Pitfalls
- Abstract: To the Editor.-Recently, Archives of Pathology & Laboratory Medicine dedicated 3 parts to updated information on melanoma and melanocytic proliferations, which is very timely and important. This letter is to discuss a few diagnostic pitfalls in melanoma about which we have recently learned. A ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: To the Editor.-Recently, Archives of Pathology & Laboratory Medicine dedicated 3 parts to updated information on melanoma and melanocytic proliferations, which is very timely and important. This letter is to discuss a few diagnostic pitfalls in melanoma about which we have recently learned. A ... (Publication: Archives of Pathology & Laboratory Medicine)
- Epithelioid Lesions of the Serosa
- Abstract: Context.-Diagnosing epithelioid serosal lesions remains a challenge because numerous different processes-primary or secondary, benign or malignant-occur in body cavities, some of which are very rare. Objectives.-To review the newest literature and to describe the morphologic criteria and ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Diagnosing epithelioid serosal lesions remains a challenge because numerous different processes-primary or secondary, benign or malignant-occur in body cavities, some of which are very rare. Objectives.-To review the newest literature and to describe the morphologic criteria and ... (Publication: Archives of Pathology & Laboratory Medicine)
- Introduction to Continuing Special Series
- Abstract: The following articles represent the next special section in a continuing series of special sections or special issues entitled ''Insights and Controversies in Pathology Each special section consists of a group of articles providing the most current knowledge, recent advances, and areas of ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: The following articles represent the next special section in a continuing series of special sections or special issues entitled ''Insights and Controversies in Pathology Each special section consists of a group of articles providing the most current knowledge, recent advances, and areas of ... (Publication: Archives of Pathology & Laboratory Medicine)
- Intravascular Large B-Cell Lymphoma
- Abstract: A rare type of diffuse large B-cell lymphoma, intravascular large B-cell lymphoma primarily affects the middleaged to elderly population, with a slight predominance in men. By the time of presentation, most patients have advanced, disseminated disease, and often the diagnosis is made at autopsy. ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: A rare type of diffuse large B-cell lymphoma, intravascular large B-cell lymphoma primarily affects the middleaged to elderly population, with a slight predominance in men. By the time of presentation, most patients have advanced, disseminated disease, and often the diagnosis is made at autopsy. ... (Publication: Archives of Pathology & Laboratory Medicine)
- Utility of Immunohistochemical Staining With FLI1, D2-40, CD31, and CD34 in the Diagnosis of Acquired Immunodeficiency Syndrome-Related and Non-Acquired Immunodeficiency Syndrome-Related Kaposi Sarcoma
- Abstract: Context.-Kaposi sarcoma (KS) is a vascular tumor frequently associated with advanced human immunodeficiency virus infection, advanced age, or iatrogenic immunosuppression. Immunohistochemistry for CD31 and CD34, and more recently for FLI1 and D2-40, has been used as ancillary diagnostic tests for ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Kaposi sarcoma (KS) is a vascular tumor frequently associated with advanced human immunodeficiency virus infection, advanced age, or iatrogenic immunosuppression. Immunohistochemistry for CD31 and CD34, and more recently for FLI1 and D2-40, has been used as ancillary diagnostic tests for ... (Publication: Archives of Pathology & Laboratory Medicine)
- Human Immunodeficiency Virus-Related Gastrointestinal Pathology: A Southern Africa Perspective With Review of the Literature (Part 1: Infections)
- Abstract: Context.-Human immunodeficiency virus infection is rife in sub-Saharan Africa and in southern Africa in particular. Despite the increasing availability of antiretroviral therapy in this region, opportunistic infections remain common and frequently involve the gastrointestinal tract. Objective.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Mar 2012 00:00:00 -060
- Abstract: Context.-Human immunodeficiency virus infection is rife in sub-Saharan Africa and in southern Africa in particular. Despite the increasing availability of antiretroviral therapy in this region, opportunistic infections remain common and frequently involve the gastrointestinal tract. Objective.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
- Nevus/Melanocytoma/Melanoma' Nosologic Chaos/In Reply
- Abstract: To the Editor.-I am not a dermatopathologist and will not weigh in on the diagnostic issues raised by Zembowicz and Scolyer1 in their article in the March 2011 issue of Archives of Pathology & Laboratory Medicine, but their proposal to create a classification of melanocytoma for a primary, ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: To the Editor.-I am not a dermatopathologist and will not weigh in on the diagnostic issues raised by Zembowicz and Scolyer1 in their article in the March 2011 issue of Archives of Pathology & Laboratory Medicine, but their proposal to create a classification of melanocytoma for a primary, ... (Publication: Archives of Pathology & Laboratory Medicine)
- Comparative Evaluation of High-Throughput Small-Core (0.6-mm) and Large-Core (2-mm) Thyroid Tissue Microarray: Is Larger Better'
- Abstract: Context.-Tissue microarrays (TMAs) are useful in gene/ protein expression profiling of large number of tumors. Several studies have validated that a 0.6-mm core of a large tumor would give results similar to results of the whole section. However, cores from colloid-filled thyroid follicles, for ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Tissue microarrays (TMAs) are useful in gene/ protein expression profiling of large number of tumors. Several studies have validated that a 0.6-mm core of a large tumor would give results similar to results of the whole section. However, cores from colloid-filled thyroid follicles, for ... (Publication: Archives of Pathology & Laboratory Medicine)
- Evaluation of Napsin A, Cytokeratin 5/6, p63, and Thyroid Transcription Factor 1 in Adenocarcinoma Versus Squamous Cell Carcinoma of the Lung
- Abstract: Context.-The distinction of lung adenocarcinoma from other types of primary lung malignancies is important clinically. Accurate morphologic classification is often hindered because 70% of lung cancers are diagnosed on limited fine-needle aspiration or transbronchial biopsy specimens. Although ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-The distinction of lung adenocarcinoma from other types of primary lung malignancies is important clinically. Accurate morphologic classification is often hindered because 70% of lung cancers are diagnosed on limited fine-needle aspiration or transbronchial biopsy specimens. Although ... (Publication: Archives of Pathology & Laboratory Medicine)
- Formalin Fixation/In Reply
- Abstract: To the Editor.-I noted with interest the article by Kothmaier et al,1 entitled ''Comparison of Formalin-Free Tissue Fixatives: A Proteomic Study Testing Their Application for Routine Pathology and Research although I am afraid their work may be in vain. In 2005, I was involved in a small study ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: To the Editor.-I noted with interest the article by Kothmaier et al,1 entitled ''Comparison of Formalin-Free Tissue Fixatives: A Proteomic Study Testing Their Application for Routine Pathology and Research although I am afraid their work may be in vain. In 2005, I was involved in a small study ... (Publication: Archives of Pathology & Laboratory Medicine)
- Cutaneous Meningioma
- Abstract: Cutaneous meningioma is a rare tumor that most commonly occurs on the scalp and occurs in both congenital and acquired forms. It invokes a wide clinical differential diagnosis, but diagnosis is based on characteristic histologic and cytologic findings. Congenital lesions can often present years ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Cutaneous meningioma is a rare tumor that most commonly occurs on the scalp and occurs in both congenital and acquired forms. It invokes a wide clinical differential diagnosis, but diagnosis is based on characteristic histologic and cytologic findings. Congenital lesions can often present years ... (Publication: Archives of Pathology & Laboratory Medicine)
- Aggressive Angiomyxoma
- Abstract: Aggressive angiomyxoma is a raremesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Aggressive angiomyxoma is a raremesenchymal tumor that most commonly arises in the vulvovaginal region, perineum, and pelvis of women. The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with local recurrence. Patients often present with ... (Publication: Archives of Pathology & Laboratory Medicine)
- A Histopathologic Analysis of Eyes Primarily Enucleated for Advanced Intraocular Retinoblastoma From a Developing Country
- Abstract: Context.-In eyes enucleated for retinoblastoma, presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Objective.-To evaluate histopathologic features in children with retinoblastoma in our population and establish relationship ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-In eyes enucleated for retinoblastoma, presence of histopathologic high-risk factors is associated with a higher risk of local recurrence and systemic metastasis. Objective.-To evaluate histopathologic features in children with retinoblastoma in our population and establish relationship ... (Publication: Archives of Pathology & Laboratory Medicine)
- Staffing Benchmarks for Clinical Laboratories: A College of American Pathologists Q-Probes Study of Laboratory Staffing at 98 Institutions
- Abstract: Context.-Publicly available information concerning laboratory staffing benchmarks is scarce. One of the few publications on this topic summarized the findings of a QProbes study performed in 2004. This publication reports a similar survey with data collected in 2010. Objective.-To assess the ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Publicly available information concerning laboratory staffing benchmarks is scarce. One of the few publications on this topic summarized the findings of a QProbes study performed in 2004. This publication reports a similar survey with data collected in 2010. Objective.-To assess the ... (Publication: Archives of Pathology & Laboratory Medicine)
- Performance Evaluation of the Sysmex XE-5000 Hematology Analyzer for White Blood Cell Analysis in Cerebrospinal Fluid
- Abstract: Context.-The newest generation hematology analyzer, Sysmex XE-5000 (Sysmex Corporation, Kobe, Japan) is equipped with an improved body fluid analysis mode. Objective.-To evaluate the applicability of the XE-5000 analyzer to white blood cell (WBC) analysis in cerebrospinal fluid (CSF). Design.-A ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-The newest generation hematology analyzer, Sysmex XE-5000 (Sysmex Corporation, Kobe, Japan) is equipped with an improved body fluid analysis mode. Objective.-To evaluate the applicability of the XE-5000 analyzer to white blood cell (WBC) analysis in cerebrospinal fluid (CSF). Design.-A ... (Publication: Archives of Pathology & Laboratory Medicine)
- Revolution in Lung Cancer: New Challenges for the Surgical Pathologist
- Abstract: To the Editor.-As we begin the magical, mystery journey into the age of personalized medicine, molecular- targeted therapy, and tumorspecific therapy, potentially highly relevant, precise, and detailed diagnostic information gathered over decades is being essentially ignored. It is quite possible ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: To the Editor.-As we begin the magical, mystery journey into the age of personalized medicine, molecular- targeted therapy, and tumorspecific therapy, potentially highly relevant, precise, and detailed diagnostic information gathered over decades is being essentially ignored. It is quite possible ... (Publication: Archives of Pathology & Laboratory Medicine)
- Progressive Granulomatous Pneumonitis in Response to Cosmetic Subcutaneous Silicone Injections in a Patient With HIV-1 Infection: Case Report and Review of the Literature
- Abstract: Silicone, commonly used in cosmetic procedures owing to its presumed inertness, can yield serious sequelae including acute embolization and pneumonitis. Chronic pulmonary sequelae in response to silicone injection have not been previously described. We report a case of chronic progressive ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Silicone, commonly used in cosmetic procedures owing to its presumed inertness, can yield serious sequelae including acute embolization and pneumonitis. Chronic pulmonary sequelae in response to silicone injection have not been previously described. We report a case of chronic progressive ... (Publication: Archives of Pathology & Laboratory Medicine)
- Malignant Struma Ovarii: A Blinded Study of 86 Cases Assessing Which Histologic Features Correlate With Aggressive Clinical Behavior
- Abstract: Context.-Struma ovarii exhibiting malignant histology are uncommon, and an aggressive clinical course in the form of initial extraovarian spread or recurrence is even more exceptional for these tumors. Objective.-To determine whether specific histologic features have predictive value in ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Struma ovarii exhibiting malignant histology are uncommon, and an aggressive clinical course in the form of initial extraovarian spread or recurrence is even more exceptional for these tumors. Objective.-To determine whether specific histologic features have predictive value in ... (Publication: Archives of Pathology & Laboratory Medicine)
- The Positive Impact of Simultaneous Implementation of the BD FocalPoint GS Imaging System and Lean Principles on the Operation of Gynecologic Cytology
- Abstract: Context.-Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles. Objective.-To determine the combined impact of the FocalPoint Guided ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Our cytology laboratory, like many others, is under pressure to improve quality and provide test results faster while decreasing costs. We sought to address these issues by introducing new technology and lean principles. Objective.-To determine the combined impact of the FocalPoint Guided ... (Publication: Archives of Pathology & Laboratory Medicine)
- ''Nevus/Melanocytoma/Melanoma'': That Which We Call a Rose by Any Other Name Would Smell as Sweet
- Abstract: To the Editor.-In the article ''Nevus/ Melanocytoma/Melanoma: An Emerging Paradigm for Classification of Melanocytic Neoplasms1 the authors suggested expansion of the dichotomous classification scheme of melanocytic neoplasms, currently including entirely benign and entirely malignant, to include a ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: To the Editor.-In the article ''Nevus/ Melanocytoma/Melanoma: An Emerging Paradigm for Classification of Melanocytic Neoplasms1 the authors suggested expansion of the dichotomous classification scheme of melanocytic neoplasms, currently including entirely benign and entirely malignant, to include a ... (Publication: Archives of Pathology & Laboratory Medicine)
- Consensus Statement on Effective Communication of Urgent Diagnoses and Significant, Unexpected Diagnoses in Surgical Pathology and Cytopathology From the College of American Pathologists and Association of Directors of Anatomic and Surgical Pathology
- Abstract: Context.-Recognizing the difficulty in applying the concept of critical values to anatomic pathology diagnoses, the College of American Pathologists and the Association of Directors of Anatomic and Surgical Pathology have chosen to reevaluate the concept of critical diagnoses. Objective.-To promote ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Recognizing the difficulty in applying the concept of critical values to anatomic pathology diagnoses, the College of American Pathologists and the Association of Directors of Anatomic and Surgical Pathology have chosen to reevaluate the concept of critical diagnoses. Objective.-To promote ... (Publication: Archives of Pathology & Laboratory Medicine)
- Intraocular Medulloepithelioma
- Abstract: Intraocular medulloepithelioma is a congenital tumor of the ciliary epithelium that typically presents during the first decade of life. The histologic diagnosis is based on characteristic ribbons of pseudostratified neuroepithelium admixed with loose mesenchymal tissue rich in hyaluronic acid, ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Intraocular medulloepithelioma is a congenital tumor of the ciliary epithelium that typically presents during the first decade of life. The histologic diagnosis is based on characteristic ribbons of pseudostratified neuroepithelium admixed with loose mesenchymal tissue rich in hyaluronic acid, ... (Publication: Archives of Pathology & Laboratory Medicine)
- State Pathology Societies and the Future of Pathology
- Abstract: In this time of significant change in pathology and medicine, pathology's future is uncertain. Many issues, including the emergence of molecular medicine, the demand for personalized medicine, confusing payment schemes, increasing governmental regulation, medical education challenges, ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: In this time of significant change in pathology and medicine, pathology's future is uncertain. Many issues, including the emergence of molecular medicine, the demand for personalized medicine, confusing payment schemes, increasing governmental regulation, medical education challenges, ... (Publication: Archives of Pathology & Laboratory Medicine)
- Napsin A, a New Marker for Lung Adenocarcinoma, Is Complementary and More Sensitive and Specific Than Thyroid Transcription Factor 1 in the Differential Diagnosis of Primary Pulmonary Carcinoma: Evaluation of 1674 Cases by Tissue Microarray
- Abstract: Context.-Differentiation of non-small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Differentiation of non-small cell carcinoma into histologic types is important because of new, successful therapies that target lung adenocarcinoma (ACA). TTF-1 is a favored marker for lung ACA but has limited sensitivity and specificity. Napsin A (Nap-A) is a functional aspartic ... (Publication: Archives of Pathology & Laboratory Medicine)
- Atypical Apocrine Adenosis of the Breast: Long-term Follow-up in 37 Patients
- Abstract: Context.-Atypical apocrine adenosis is a rare breast lesion in which the cellular population demonstrates cytologic alterations that may be confused with malignancy. The clinical significance and management of atypical apocrine adenosis are unclear because of the lack of long-term follow-up ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Feb 2012 00:00:00 -060
- Abstract: Context.-Atypical apocrine adenosis is a rare breast lesion in which the cellular population demonstrates cytologic alterations that may be confused with malignancy. The clinical significance and management of atypical apocrine adenosis are unclear because of the lack of long-term follow-up ... (Publication: Archives of Pathology & Laboratory Medicine)
- Antiphospholipid Antibody Syndrome
- Abstract: Antiphospholipid antibodies are directed against phospholipid- protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a common cause of acquired thrombophilia and is characterized by venous or ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: Antiphospholipid antibodies are directed against phospholipid- protein complexes and include lupus anticoagulant, anticardiolipin antibodies, and anti-beta-2 glycoprotein I antibodies. Antiphospholipid antibody syndrome is a common cause of acquired thrombophilia and is characterized by venous or ... (Publication: Archives of Pathology & Laboratory Medicine)
- Granulomatous Dermatitis due to Malassezia sympodialis
- Abstract: A 67-year-old man, with multiple skin lesions that appeared over 2 years, had biopsies that disclosed granulomatous dermatitis with associated small yeasts. The urinary antigen test results were negative for Histoplasma infection; cultures from the biopsies did not grow any fungi or other potential ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: A 67-year-old man, with multiple skin lesions that appeared over 2 years, had biopsies that disclosed granulomatous dermatitis with associated small yeasts. The urinary antigen test results were negative for Histoplasma infection; cultures from the biopsies did not grow any fungi or other potential ... (Publication: Archives of Pathology & Laboratory Medicine)
- Solution Densities and Estimated Total Protein Contents Associated With Inappropriate Flotation of Separator Gel in Different Blood Collection Tubes
- Abstract: * Context.-Clinical samples that have densities greater than that of separator gel in specimen tubes may exhibit gel flotation to the top of the specimen upon centrifugation. Inappropriate separator gel flotation can occur in specimens with high protein content. In automated analytical systems, gel ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: * Context.-Clinical samples that have densities greater than that of separator gel in specimen tubes may exhibit gel flotation to the top of the specimen upon centrifugation. Inappropriate separator gel flotation can occur in specimens with high protein content. In automated analytical systems, gel ... (Publication: Archives of Pathology & Laboratory Medicine)
- Carcinoma of the Breast With Choriocarcinomatous Features
- Abstract: Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: Choriocarcinomatous differentiation has been described in tumors arising from many organs including lung, rectum, colon, stomach, bladder, and rarely breast. Mammary carcinoma with choriocarcinomatous features is a rare variant of breast metaplastic carcinoma characterized by malignant cells ... (Publication: Archives of Pathology & Laboratory Medicine)
- Genomic Aberrations in Salivary Duct Carcinoma Arising in Warthin Tumor of Parotid Gland: DNA Microarray and HER2 Fluorescence In Situ Hybridization
- Abstract: * Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: * Carcinoma arising from Warthin tumor is extremely rare. A 79-year-old man was admitted for a firm, well-defined, 5-cm left infra-auricular mass. Aspiration cytology showed many lymphohistiocytes and oncocytes in a proteinaceous background, compatible with Warthin tumor. A left superficial ... (Publication: Archives of Pathology & Laboratory Medicine)
- Unrecognized Risks Associated With New Cervical Screening Guidelines for Younger Women
- Abstract: To the Editor.-We appreciate the editorial commentary by Raymond H. Kaufman, MD, entitled ''Cancer Screening in the Young Female 1 which accompanied our article, ''Follow- up Findings in Young Females With High-Grade Squamous Intraepithelial Lesion Papanicolaou Test Results 2 in the March 2011 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Thu, 01 Sep 2011 00:00:00 -050
- Abstract: To the Editor.-We appreciate the editorial commentary by Raymond H. Kaufman, MD, entitled ''Cancer Screening in the Young Female 1 which accompanied our article, ''Follow- up Findings in Young Females With High-Grade Squamous Intraepithelial Lesion Papanicolaou Test Results 2 in the March 2011 ... (Publication: Archives of Pathology & Laboratory Medicine)
- Mislabeling of Cases, Specimens, Blocks, and Slides: A College of American Pathologists Study of 136 Institutions
- Abstract: * Context.-Accurate specimen labeling is a major patientsafety initiative by the Joint Commission and the College of American Pathologists. Inadequate specimen labels have led to patient injury from wrong patient diagnosis, wrong side treatment, and delay in diagnosis. Objectives.-To quantify the ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Context.-Accurate specimen labeling is a major patientsafety initiative by the Joint Commission and the College of American Pathologists. Inadequate specimen labels have led to patient injury from wrong patient diagnosis, wrong side treatment, and delay in diagnosis. Objectives.-To quantify the ... (Publication: Archives of Pathology & Laboratory Medicine)
- The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma
- Abstract: * Context.-One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors. Objective.-To investigate whether IMP3 can be used as a new biomarker to predict the recurrence ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Context.-One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors. Objective.-To investigate whether IMP3 can be used as a new biomarker to predict the recurrence ... (Publication: Archives of Pathology & Laboratory Medicine)
- Nodal Marginal Zone Lymphoma With Increased Large Cells: Myth Versus Entity
- Abstract: To the Editor.-Nodal marginal zone B-cell lymphoma (NMZL) has recently been recognized in the World Health Organization (WHO) lymphoma classification1 as a separate clinical and pathologic entity. Nodal marginal zone lymphomas are considered indolent lymphomas by the WHO monogram.1,2 Yet, the 7 or ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: To the Editor.-Nodal marginal zone B-cell lymphoma (NMZL) has recently been recognized in the World Health Organization (WHO) lymphoma classification1 as a separate clinical and pathologic entity. Nodal marginal zone lymphomas are considered indolent lymphomas by the WHO monogram.1,2 Yet, the 7 or ... (Publication: Archives of Pathology & Laboratory Medicine)
- Expression of Insulin-Like Growth Factor II mRNA-Binding Protein 3 in Human Esophageal Adenocarcinoma and Its Precursor Lesions
- Abstract: Context.-Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 in esophageal adenocarcinoma (EAC) and its precursor lesions including distinctive ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 in esophageal adenocarcinoma (EAC) and its precursor lesions including distinctive ... (Publication: Archives of Pathology & Laboratory Medicine)
- Detection of Nucleophosmin 1 Mutations by Quantitative Real-Time Polymerase Chain Reaction Versus Capillary Electrophoresis: A Comparative Study
- Abstract: Context.-Nucleophosmin 1 (NPM1) is the most commonly mutated gene in acute myeloid leukemia. Detection of NPM1 mutations is useful for stratifying patients for therapy, predicting prognosis, and assessing for minimal residual disease. Several methods have been developed to rapidly detect NPM1 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Nucleophosmin 1 (NPM1) is the most commonly mutated gene in acute myeloid leukemia. Detection of NPM1 mutations is useful for stratifying patients for therapy, predicting prognosis, and assessing for minimal residual disease. Several methods have been developed to rapidly detect NPM1 ... (Publication: Archives of Pathology & Laboratory Medicine)
- Merkel Cell Carcinoma of the Genitourinary Tract
- Abstract: * Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary ... (Publication: Archives of Pathology & Laboratory Medicine)
- Angiocentric Glioma: A Clinicopathologic Review of 5 Tumors With Identification of Associated Cortical Dysplasia
- Abstract: * Context.-Angiocentric glioma is a rare, epilepsy-associated, low-grade neoplasm with a characteristic perivascular growth pattern. Objective.-To describe the clinicopathologic features of 5 angiocentric gliomas and to evaluate for coexistent malformation of cortical development/cortical ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Context.-Angiocentric glioma is a rare, epilepsy-associated, low-grade neoplasm with a characteristic perivascular growth pattern. Objective.-To describe the clinicopathologic features of 5 angiocentric gliomas and to evaluate for coexistent malformation of cortical development/cortical ... (Publication: Archives of Pathology & Laboratory Medicine)
- Superficial Acral Fibromyxoma: An Overview
- Abstract: Superficial acral fibromyxoma is a rare, slow-growing soft tissue tumor, which is commonly located in the periungual and subungual regions of the fingers and toes in adults. To date, fewer than 50 cases have been reported worldwide. Microscopic examination reveals a moderately circumscribed, ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Superficial acral fibromyxoma is a rare, slow-growing soft tissue tumor, which is commonly located in the periungual and subungual regions of the fingers and toes in adults. To date, fewer than 50 cases have been reported worldwide. Microscopic examination reveals a moderately circumscribed, ... (Publication: Archives of Pathology & Laboratory Medicine)
- A Study of Pathologic Risk Factors in Postchemoreduced, Enucleated Specimens of Advanced Retinoblastomas in a Developing Country
- Abstract: * Context.-Advanced cases of retinoblastoma are treated with chemoreduction followed by enucleation. Further adjuvant therapy is recommended in patients with known pathologic risk factors (PRFs). Objectives.-To determine the PRFs in enucleated specimens after chemoreduction and their association ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Context.-Advanced cases of retinoblastoma are treated with chemoreduction followed by enucleation. Further adjuvant therapy is recommended in patients with known pathologic risk factors (PRFs). Objectives.-To determine the PRFs in enucleated specimens after chemoreduction and their association ... (Publication: Archives of Pathology & Laboratory Medicine)
- Immunohistochemical Study of Correlation Between Histologic Subtype and Expression of Epithelial-Mesenchymal Transition-Related Proteins in Synovial Sarcomas
- Abstract: Context.-Synovial sarcomas are mesenchymal tumors with epithelial nature and comprise biphasic and monophasic fibrous subtypes. However, factors determining epithelial or spindle cell differentiation are still unexplored. Aberrant epithelial-mesenchymal transition has been implicated in the ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Synovial sarcomas are mesenchymal tumors with epithelial nature and comprise biphasic and monophasic fibrous subtypes. However, factors determining epithelial or spindle cell differentiation are still unexplored. Aberrant epithelial-mesenchymal transition has been implicated in the ... (Publication: Archives of Pathology & Laboratory Medicine)
- Ruptured Myocardial Abscess Causing Left Ventricle to Pulmonary Artery Communication in an Infant With Community-Associated Methicillin-Resistant Staphylococcus aureus Endocarditis
- Abstract: Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed communityassociated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed communityassociated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed ... (Publication: Archives of Pathology & Laboratory Medicine)
- Clinical Performance of a Human Papillomavirus Messenger RNA Test (Aptima HPV Assay) on Residual Material From Archived 3-Year-Old PreservCyt Samples With Low-Grade Squamous Intraepithelial Lesion
- Abstract: Context.-Human papillomavirus (HPV) testing is widely used in the triage of women with a borderline smear result but the efficiency of testingwomen with low-grade squamous intraepithelial lesion (LSIL) is less clear, mainly because of lack of specificity. New HPV tests are emerging, which detect ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Human papillomavirus (HPV) testing is widely used in the triage of women with a borderline smear result but the efficiency of testingwomen with low-grade squamous intraepithelial lesion (LSIL) is less clear, mainly because of lack of specificity. New HPV tests are emerging, which detect ... (Publication: Archives of Pathology & Laboratory Medicine)
- Histochemical Identification of Microcrystalline Cellulose, Calcium Oxalate, and Talc in Tissue Sections/In Reply
- Abstract: To the Editor.-We read with interest the article by Sigdel, Gemind, and Tomashefski1 describing the use of a modified Russell Movat pentachrome stain for distinguishing microcrystalline cellulose (MCC) from other particles found in lung tissue specimens, which was published in the February 2011 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: To the Editor.-We read with interest the article by Sigdel, Gemind, and Tomashefski1 describing the use of a modified Russell Movat pentachrome stain for distinguishing microcrystalline cellulose (MCC) from other particles found in lung tissue specimens, which was published in the February 2011 ... (Publication: Archives of Pathology & Laboratory Medicine)
- Embryonal Central Nervous System Neoplasms Arising in Infants and Young Children: A Pediatric Brain Tumor Consortium Study
- Abstract: Context.-Medulloblastomas (MBs) and atypical teratoid/ rhabdoid tumors (AT/RTs) arising in infants and children can be difficult to distinguish; however, histologic characterization is prognostically important. Objective.-To determine histologic and phenotypic markers associated with utility with ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Medulloblastomas (MBs) and atypical teratoid/ rhabdoid tumors (AT/RTs) arising in infants and children can be difficult to distinguish; however, histologic characterization is prognostically important. Objective.-To determine histologic and phenotypic markers associated with utility with ... (Publication: Archives of Pathology & Laboratory Medicine)
- Genomic Pathology: Challenges for Implementation
- Abstract: Currently, the practice of pathology is undergoing a transition in which the focus is on individual molecular tests for specific predictive biomarkers for various types of cancers.1 This current model is predominantly based on single tests for 1 or more biomarkers to predict possible response to 1 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Currently, the practice of pathology is undergoing a transition in which the focus is on individual molecular tests for specific predictive biomarkers for various types of cancers.1 This current model is predominantly based on single tests for 1 or more biomarkers to predict possible response to 1 ... (Publication: Archives of Pathology & Laboratory Medicine)
- An Immunohistochemical Panel to Differentiate Metastatic Breast Carcinoma to Skin From Primary Sweat Gland Carcinomas With a Review of the Literature
- Abstract: * Context.-Approximately 25% of patients with breast cancer develop cutaneous metastases. Sweat gland carcinomas (SGCs) account for about 0.05% of all cutaneous neoplasms. Cutaneous metastases of breast carcinoma (CMBCs) (especially the ductal type) can be difficult to distinguish from SGCs. ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: * Context.-Approximately 25% of patients with breast cancer develop cutaneous metastases. Sweat gland carcinomas (SGCs) account for about 0.05% of all cutaneous neoplasms. Cutaneous metastases of breast carcinoma (CMBCs) (especially the ductal type) can be difficult to distinguish from SGCs. ... (Publication: Archives of Pathology & Laboratory Medicine)
- Effects of the Change in Cutoff Values for Human Epidermal Growth Factor Receptor 2 Status by Immunohistochemistry and Fluorescence In Situ Hybridization: A Study Comparing Conventional Brightfield Microscopy, Image Analysis-Assisted Microscopy, and Interobserver Variation
- Abstract: Context.-New guidelines for HER2 testing have been introduced. Objectives.-To evaluate the difference in HER2 assessment after introduction of new cutoff levels for both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) and to compare interobserver agreement and time to score ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-New guidelines for HER2 testing have been introduced. Objectives.-To evaluate the difference in HER2 assessment after introduction of new cutoff levels for both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) and to compare interobserver agreement and time to score ... (Publication: Archives of Pathology & Laboratory Medicine)
- Twenty-Four-Hour Bence-Jones Protein Determinations: Can We Ensure Accuracy'
- Abstract: Context.-Light chain disease represents 15% to 20% of cases of multiple myeloma. Current guidelines recommend monitoring these patients with 24-hour urine collections. Objective.-To determine the reliability of 24-hour urine collections in assessing the amount of Bence-Jones protein (BJP). ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Light chain disease represents 15% to 20% of cases of multiple myeloma. Current guidelines recommend monitoring these patients with 24-hour urine collections. Objective.-To determine the reliability of 24-hour urine collections in assessing the amount of Bence-Jones protein (BJP). ... (Publication: Archives of Pathology & Laboratory Medicine)
- Intramuscular Lipoma Arising Within the Pectoralis Major Muscle Presenting as a Radiographically Detected Breast Mass
- Abstract: Lipomas are commonly encountered benign mesenchymal neoplasms composed of adipocytes that arise in the superficial subcutaneous tissues of the extremities and trunk. Occasionally, these tumors can originate from either within muscle (intramuscular) or between muscles (intermuscular). The former ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Lipomas are commonly encountered benign mesenchymal neoplasms composed of adipocytes that arise in the superficial subcutaneous tissues of the extremities and trunk. Occasionally, these tumors can originate from either within muscle (intramuscular) or between muscles (intermuscular). The former ... (Publication: Archives of Pathology & Laboratory Medicine)
- Effect of Heterogeneous Distribution of Monosomy 3 on Prognosis in Uveal Melanoma
- Abstract: Context.-Fluorescence in situ hybridization (FISH) analyses on tumor sections and on isolated nuclei showed that even low numbers of cells with monosomy of chromosome 3 adversely affected survival. Objective.-To determine what percentage of uveal melanoma cells with monosomy of chromosome 3 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Mon, 01 Aug 2011 00:00:00 -050
- Abstract: Context.-Fluorescence in situ hybridization (FISH) analyses on tumor sections and on isolated nuclei showed that even low numbers of cells with monosomy of chromosome 3 adversely affected survival. Objective.-To determine what percentage of uveal melanoma cells with monosomy of chromosome 3 ... (Publication: Archives of Pathology & Laboratory Medicine)
- The Pathologist: Part of the Team
- Abstract: To the Editor.-John Deck, MD, FRCPC, was very kind to acknowledge my work at the National Military Hospital (NMH) in Kabul, Afghanistan, during 2007-2008.1 Although I did not have the privilege of meeting him during my year in Afghanistan, I was fortunate to visit the CURE International Hospital in ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: To the Editor.-John Deck, MD, FRCPC, was very kind to acknowledge my work at the National Military Hospital (NMH) in Kabul, Afghanistan, during 2007-2008.1 Although I did not have the privilege of meeting him during my year in Afghanistan, I was fortunate to visit the CURE International Hospital in ... (Publication: Archives of Pathology & Laboratory Medicine)
- Melanocytic Lesions: Current State of Knowledge-Part III
- Abstract: This third part of the Special Section on Melanoma and Melanocytic Proliferations concludes the series that started in the December 2010 issue of the Archives of Pathology & Laboratory Medicine. The goal was to include a very extensive review of clinical, morphologic, and molecular features of ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: This third part of the Special Section on Melanoma and Melanocytic Proliferations concludes the series that started in the December 2010 issue of the Archives of Pathology & Laboratory Medicine. The goal was to include a very extensive review of clinical, morphologic, and molecular features of ... (Publication: Archives of Pathology & Laboratory Medicine)
- CallWall: Tracking Resident Calls to Improve Clinical Utilization of Pathology Laboratories
- Abstract: Context.-Clinical pathology (CP) laboratories are used for millions of tests each year. These lead to thousands of calls to CP residents. However, although laboratory utilization is a frequent topic of study, clinical utilization-the content of the interactions between clinicians and CP ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Clinical pathology (CP) laboratories are used for millions of tests each year. These lead to thousands of calls to CP residents. However, although laboratory utilization is a frequent topic of study, clinical utilization-the content of the interactions between clinicians and CP ... (Publication: Archives of Pathology & Laboratory Medicine)
- Mitochondrial Disorders of DNA Polymerase [gamma] Dysfunction: From Anatomic to Molecular Pathology Diagnosis
- Abstract: Context.-Primarymitochondrial dysfunction is one of the most common causes of inherited disorders predominantly involving the neuromuscular system. Advances in the molecular study of mitochondrial DNA have changed our vision and our approach to primary mitochondrial disorders. Many of ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Primarymitochondrial dysfunction is one of the most common causes of inherited disorders predominantly involving the neuromuscular system. Advances in the molecular study of mitochondrial DNA have changed our vision and our approach to primary mitochondrial disorders. Many of ... (Publication: Archives of Pathology & Laboratory Medicine)
- Molecular Diagnostics in Melanoma: Current Status and Perspectives
- Abstract: * Context.-In the current ''molecular'' era, the advent of technology, such as array-based platforms, systems biology, and genome-wide approaches, has made it possible to examine human cancers, including melanoma, for genetic mutations, deletions, amplification, differentially regulated genes, and ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-In the current ''molecular'' era, the advent of technology, such as array-based platforms, systems biology, and genome-wide approaches, has made it possible to examine human cancers, including melanoma, for genetic mutations, deletions, amplification, differentially regulated genes, and ... (Publication: Archives of Pathology & Laboratory Medicine)
- Development of an Evidence-Based Approach to External Quality Assurance for Breast Cancer Hormone Receptor Immunohistochemistry: Comparison of Reference Values
- Abstract: * Context.-External quality assurance and proficiency testing programs for breast cancer predictive biomarkers are based largely on traditional ad hoc design; at present there is no universal consensus on definition of a standard reference value for samples used in external quality assurance ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-External quality assurance and proficiency testing programs for breast cancer predictive biomarkers are based largely on traditional ad hoc design; at present there is no universal consensus on definition of a standard reference value for samples used in external quality assurance ... (Publication: Archives of Pathology & Laboratory Medicine)
- CD34^sup +^ Cell Enumeration by Flow Cytometry: A Comparison of Systems and Methodologies
- Abstract: Context.-An increasing number of medical centers can collect bone marrow, peripheral blood, or umbilical cord stem cells. Pathology laboratories should accommodate this trend, but investment in additional equipment may be impractical. Objectives.-To compare CD34 cell counting results by using 2 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-An increasing number of medical centers can collect bone marrow, peripheral blood, or umbilical cord stem cells. Pathology laboratories should accommodate this trend, but investment in additional equipment may be impractical. Objectives.-To compare CD34 cell counting results by using 2 ... (Publication: Archives of Pathology & Laboratory Medicine)
- Update on Fluorescence In Situ Hybridization in Melanoma: State of the Art
- Abstract: Context.-Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4- probe multicolor FISH probe ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Recent advances in understanding the molecular basis of melanoma have resulted in development of fluorescence in situ hybridization (FISH) protocols designed to detect genetic abnormalities discriminating melanoma from nevi. The most extensively studied is a 4- probe multicolor FISH probe ... (Publication: Archives of Pathology & Laboratory Medicine)
- Trainable Immunohistochemical HER2/neu Image Analysis: A Multisite Performance Study Using 260 Breast Tissue Specimens
- Abstract: * Context.-Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/neu scoring scheme to adapt to the staining characteristics of different reagents. Objective.-To compare the ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/neu scoring scheme to adapt to the staining characteristics of different reagents. Objective.-To compare the ... (Publication: Archives of Pathology & Laboratory Medicine)
- Recurrence Risk and Margin Status in Granular Cell Tumors of the Breast: A Clinicopathologic Study of 13 Patients
- Abstract: * Context.-Granular cell tumors (GCTs) of the breast are rare neoplasms that mimic epithelial malignancy clinically and rarely occur in association with it. Granular cell tumors of the breast are not infrequently excised with positive margins. Reports describing risk of recurrence including data on ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-Granular cell tumors (GCTs) of the breast are rare neoplasms that mimic epithelial malignancy clinically and rarely occur in association with it. Granular cell tumors of the breast are not infrequently excised with positive margins. Reports describing risk of recurrence including data on ... (Publication: Archives of Pathology & Laboratory Medicine)
- Lentigo Maligna: Melanoma In Situ on Chronically Sun-Damaged Skin
- Abstract: Context.-Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary ... (Publication: Archives of Pathology & Laboratory Medicine)
- Are There Barriers to the Release of Paraffin Blocks for Clinical Research Trials' A College of American Pathologists Survey of 609 Laboratories
- Abstract: Context.-The number of paraffin blocks submitted for patients enrolled in clinical research trials appears to be declining. Objective.-To obtain information on laboratory policies and procedures in complying with requests to submit paraffin blocks for research. Design.-A questionnaire was sent to ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-The number of paraffin blocks submitted for patients enrolled in clinical research trials appears to be declining. Objective.-To obtain information on laboratory policies and procedures in complying with requests to submit paraffin blocks for research. Design.-A questionnaire was sent to ... (Publication: Archives of Pathology & Laboratory Medicine)
- Immunohistochemistry of Melanocytic Proliferations
- Abstract: * Context.-Histologic analysis allows accurate classification of most melanocytic lesions as benign or malignant. Only in a minority of lesions is it necessary to use other techniques as an aid in the diagnosis. Among them, most authors recommend immunohistochemistry. Objective.-To describe how to ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-Histologic analysis allows accurate classification of most melanocytic lesions as benign or malignant. Only in a minority of lesions is it necessary to use other techniques as an aid in the diagnosis. Among them, most authors recommend immunohistochemistry. Objective.-To describe how to ... (Publication: Archives of Pathology & Laboratory Medicine)
- Expression of AIF and HtrA2/Omi in Small Lymphocytic Lymphoma and Diffuse Large B-Cell Lymphoma
- Abstract: * Context.-The pathogenesis of non-Hodgkin lymphoma may involve deregulation of apoptosis. In response to apoptotic stimuli, several proapoptotic proteins are released into the cytoplasm from the mitochondria, including second mitochondria-derived activator of caspases/direct inhibitor of apoptosis ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Context.-The pathogenesis of non-Hodgkin lymphoma may involve deregulation of apoptosis. In response to apoptotic stimuli, several proapoptotic proteins are released into the cytoplasm from the mitochondria, including second mitochondria-derived activator of caspases/direct inhibitor of apoptosis ... (Publication: Archives of Pathology & Laboratory Medicine)
- Application of Thrombolytic Drugs on Clotted Blood and Bone Marrow Specimens to Generate Usable Cells for Cytogenetic Analyses
- Abstract: Context.-Clotted blood and bone marrow specimens account for a large proportion of failed cytogenetic studies. There are no published protocols describing salvage of clotted specimens such that conventional chromosome or fluorescence in situ hybridization (FISH) studies can be performed. ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Clotted blood and bone marrow specimens account for a large proportion of failed cytogenetic studies. There are no published protocols describing salvage of clotted specimens such that conventional chromosome or fluorescence in situ hybridization (FISH) studies can be performed. ... (Publication: Archives of Pathology & Laboratory Medicine)
- Acral Junctional Nevus Versus Acral Lentiginous Melanoma In Situ: A Differential Diagnosis That Should Be Based on Clinicopathologic Correlation
- Abstract: Context.-Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Acral lentiginous melanoma is the most prevalent clinical presentation of melanoma in ethnic groups other than whites and also occurs in significant numbers in North America and Europe. Despite a clear-cut clinical picture, histologic findings seen in partial biopsies may be too subtle and ... (Publication: Archives of Pathology & Laboratory Medicine)
- Aberrant Protein Expression and Promoter Methylation of p16 Gene Are Correlated With Malignant Transformation of Salivary Pleomorphic Adenoma
- Abstract: Context.-The significance of promoter methylation of the p16 gene and intracellular localization of p16 protein in the carcinogenesis of salivary carcinoma ex pleomorphic adenoma (Ca-ex-PA) is not clear. The correlation of the promoter methylation of the p16 gene and the expression and localization ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-The significance of promoter methylation of the p16 gene and intracellular localization of p16 protein in the carcinogenesis of salivary carcinoma ex pleomorphic adenoma (Ca-ex-PA) is not clear. The correlation of the promoter methylation of the p16 gene and the expression and localization ... (Publication: Archives of Pathology & Laboratory Medicine)
- Sarcomatoid Carcinoma of Esophagus
- Abstract: Sarcomatoid carcinoma of the esophagus is an uncommon malignancy, representing approximately 2% of esophageal carcinomas. It has also been referred to as carcinosarcoma, pseudosarcoma, pseudosarcomatous squamous cell carcinoma, spindle cell carcinoma, and polypoid carcinoma, reflecting the ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Sarcomatoid carcinoma of the esophagus is an uncommon malignancy, representing approximately 2% of esophageal carcinomas. It has also been referred to as carcinosarcoma, pseudosarcoma, pseudosarcomatous squamous cell carcinoma, spindle cell carcinoma, and polypoid carcinoma, reflecting the ... (Publication: Archives of Pathology & Laboratory Medicine)
- The Recurrent Nevus Phenomenon: A History of Challenge, Controversy, and Discovery
- Abstract: Context.-The diagnosis of recurrent nevus poses a potential challenge to practicing pathologists. Although most recurrent nevi show uniform microscopic findings and pose no great diagnostic difficulty, a few cases exhibit some histopathologic features similar to, and in some cases indistinguishable ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-The diagnosis of recurrent nevus poses a potential challenge to practicing pathologists. Although most recurrent nevi show uniform microscopic findings and pose no great diagnostic difficulty, a few cases exhibit some histopathologic features similar to, and in some cases indistinguishable ... (Publication: Archives of Pathology & Laboratory Medicine)
- Emergence of a High-Grade Sarcoma in a Recurrent Meningioma: Malignant Progression or Collision Tumor'
- Abstract: * Anaplastic meningiomas that resemble sarcomas often reveal clues to their meningothelial differentiation or develop in a plausible setting that confirms their meningothelial origin. Malignant mesenchymal neoplasms without obvious evidence of meningothelial differentiation or origin are more ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Anaplastic meningiomas that resemble sarcomas often reveal clues to their meningothelial differentiation or develop in a plausible setting that confirms their meningothelial origin. Malignant mesenchymal neoplasms without obvious evidence of meningothelial differentiation or origin are more ... (Publication: Archives of Pathology & Laboratory Medicine)
- An Update on Reporting Histopathologic Prognostic Factors in Melanoma
- Abstract: Context.-Accurate diagnosis of melanocytic lesions is essential for the adequate clinical management of patients. Thus, thorough reporting of histopathologic parameters, especially in the initial biopsies, is a critical component of both diagnosis and staging. Objective.-To review current data on ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: Context.-Accurate diagnosis of melanocytic lesions is essential for the adequate clinical management of patients. Thus, thorough reporting of histopathologic parameters, especially in the initial biopsies, is a critical component of both diagnosis and staging. Objective.-To review current data on ... (Publication: Archives of Pathology & Laboratory Medicine)
- Cutaneous Protothecosis
- Abstract: * Prototheca species are an achlorophyllic algae that cause infections primarily in immunocompromised individuals. At least one-half of infectious cases are cutaneous. Because protothecosis is seldom suspected clinically, patients may be subjected to various treatment modalities for extended ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Fri, 01 Jul 2011 00:00:00 -050
- Abstract: * Prototheca species are an achlorophyllic algae that cause infections primarily in immunocompromised individuals. At least one-half of infectious cases are cutaneous. Because protothecosis is seldom suspected clinically, patients may be subjected to various treatment modalities for extended ... (Publication: Archives of Pathology & Laboratory Medicine)
- Uniform Expression of Notch1, Suppressor of B-Cell-Specific Gene Expression, in Plasmablastic Lymphoma
- Abstract: Context.-Although the loss of B-lineage-specific gene expression is a distinctive feature of plasmablastic lymphoma, the underlying mechanism remains poorly understood. A candidate for this mechanism is Notch1 signaling, which interferes with the activity of B-cell-specific transcription factors ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Although the loss of B-lineage-specific gene expression is a distinctive feature of plasmablastic lymphoma, the underlying mechanism remains poorly understood. A candidate for this mechanism is Notch1 signaling, which interferes with the activity of B-cell-specific transcription factors ... (Publication: Archives of Pathology & Laboratory Medicine)
- A Fatal Central Nervous System Enterovirus 68 Infection
- Abstract: The anticipated eradication of poliovirus emphasizes the need to identify other enteroviral causes of severe central nervous system disease. Enterovirus 68 has been implicated only in cases of respiratory illness. We therefore report a case of fatal meningomyeloencephalitis caused by enterovirus 68 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: The anticipated eradication of poliovirus emphasizes the need to identify other enteroviral causes of severe central nervous system disease. Enterovirus 68 has been implicated only in cases of respiratory illness. We therefore report a case of fatal meningomyeloencephalitis caused by enterovirus 68 ... (Publication: Archives of Pathology & Laboratory Medicine)
- Practical Neuropathology Synoptic Reporting for Central Nervous System Tumors
- Abstract: Context.-Synoptic reporting for central nervous system (CNS) tumors has never been formally addressed, and neuropathologists lack practical templates that they can adapt to their laboratory information system to be compliant with College of American Pathologists (CAP) standards. Objectives.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Synoptic reporting for central nervous system (CNS) tumors has never been formally addressed, and neuropathologists lack practical templates that they can adapt to their laboratory information system to be compliant with College of American Pathologists (CAP) standards. Objectives.-To ... (Publication: Archives of Pathology & Laboratory Medicine)
- Where and by Whom Should Gastric Cancer HER2/neu Status Be Assessed' Lessons From Breast Cancer
- Abstract: The availability of an expanding armamentarium of antibodies and small-molecule inhibitors has transformed the way we practice oncology.1 By targeting key oncogenic genes and pathways, many solid tumors can now be treated in a more focused and clinically efficient manner. This revolution in ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: The availability of an expanding armamentarium of antibodies and small-molecule inhibitors has transformed the way we practice oncology.1 By targeting key oncogenic genes and pathways, many solid tumors can now be treated in a more focused and clinically efficient manner. This revolution in ... (Publication: Archives of Pathology & Laboratory Medicine)
- Molecular Signatures of Pancreatic Cancer
- Abstract: Context.-The introduction of genome- and epigenomewide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-The introduction of genome- and epigenomewide screening techniques has dramatically improved our understanding of the molecular mechanisms underlying the development of pancreatic cancer. There are now 3 recognized histologic precursors of pancreatic cancer: pancreatic intraepithelial ... (Publication: Archives of Pathology & Laboratory Medicine)
- Modern Concepts on the Role of Inflammation in Pulmonary Fibrosis
- Abstract: Context.-Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at one time was thought to be a result of inflammation in the lung. Although some forms of pulmonary fibrosis may ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Idiopathic pulmonary fibrosis is a uniformly lethal disease with limited biomarkers and no proven therapeutic intervention short of lung transplantation. Pulmonary fibrosis at one time was thought to be a result of inflammation in the lung. Although some forms of pulmonary fibrosis may ... (Publication: Archives of Pathology & Laboratory Medicine)
- Characterization of CXCR4 Expression in Chondrosarcoma of Bone
- Abstract: Context.-Alterations in molecular elements derived from the CXC chemokine receptor 4 (CXCR4)/stromalderived factor 1 (SDF-1) cytokine system have been found to strongly correlate with neoplastic progression leading to metastasis in a number of tumors, including osteosarcoma. Excluding hematologic ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Alterations in molecular elements derived from the CXC chemokine receptor 4 (CXCR4)/stromalderived factor 1 (SDF-1) cytokine system have been found to strongly correlate with neoplastic progression leading to metastasis in a number of tumors, including osteosarcoma. Excluding hematologic ... (Publication: Archives of Pathology & Laboratory Medicine)
- Four Molecular Subtypes of Colorectal Cancer and Their Precursor Lesions
- Abstract: * Context.-In addition to chromosomal instability and microsatellite instability (MSI), a third pathway, epigenetic instability, has been implicated in progression to colorectal carcinogenesis. CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that occur through ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: * Context.-In addition to chromosomal instability and microsatellite instability (MSI), a third pathway, epigenetic instability, has been implicated in progression to colorectal carcinogenesis. CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that occur through ... (Publication: Archives of Pathology & Laboratory Medicine)
- Comparison of Formalin-Free Tissue Fixatives: A Proteomic Study Testing Their Application for Routine Pathology and Research
- Abstract: Context.-Formalin-fixed, paraffin-embedded tissue is the routine processing method for diagnostics practiced in pathology departments worldwide. Objective.-To determine the potential value of non-cross-linking, formalin-free tissue fixation for diagnostics in pathology and proteomic investigations. ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Formalin-fixed, paraffin-embedded tissue is the routine processing method for diagnostics practiced in pathology departments worldwide. Objective.-To determine the potential value of non-cross-linking, formalin-free tissue fixation for diagnostics in pathology and proteomic investigations. ... (Publication: Archives of Pathology & Laboratory Medicine)
- Aberrant CpG Island Hypermethylation in Pediatric Gastric Mucosa in Association With Helicobacter pylori Infection
- Abstract: Context.-Helicobacter pylori infection is primarily acquired during childhood and persists throughout life in the absence of eradication with antibiotics. Helicobacter pylori infection induces methylation in the promoter CpG island loci in gastric epithelial cells. Thus, aberrant CpG island ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Helicobacter pylori infection is primarily acquired during childhood and persists throughout life in the absence of eradication with antibiotics. Helicobacter pylori infection induces methylation in the promoter CpG island loci in gastric epithelial cells. Thus, aberrant CpG island ... (Publication: Archives of Pathology & Laboratory Medicine)
- p63 Expression in Giant Cell-Containing Lesions of Bone and Soft Tissue
- Abstract: Context.-Previous studies have demonstrated p63 overexpression in giant cell tumors of bone and advocate its use as a potential diagnostic marker. Although routine histology is often all that is required to diagnose giant cell tumor of bone, immunohistochemistry could prove useful to distinguish it ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-Previous studies have demonstrated p63 overexpression in giant cell tumors of bone and advocate its use as a potential diagnostic marker. Although routine histology is often all that is required to diagnose giant cell tumor of bone, immunohistochemistry could prove useful to distinguish it ... (Publication: Archives of Pathology & Laboratory Medicine)
- Synoptic Reporting for Central Nervous System Tumors: Has Its Time Come'
- Abstract: In this issue of Archives of Pathology & Laboratory Medicine, an article1 is presented promoting the establishment of synoptic reporting for central nervous system (CNS) tumors, based on current College of American Pathologists' (CAP) requirements in cancer reporting, and presents example synoptic ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: In this issue of Archives of Pathology & Laboratory Medicine, an article1 is presented promoting the establishment of synoptic reporting for central nervous system (CNS) tumors, based on current College of American Pathologists' (CAP) requirements in cancer reporting, and presents example synoptic ... (Publication: Archives of Pathology & Laboratory Medicine)
- Update on Precursor and Early Lesions of Hepatocellular Carcinomas
- Abstract: Context.-There is increasing evidence to support a multistep model of the process of human hepatocarcinogenesis. Precursor lesions are characterized by the appearance of dysplastic lesions in the form of microscopic dysplastic foci and macroscopic dysplastic nodules. There are 2 types of small ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-There is increasing evidence to support a multistep model of the process of human hepatocarcinogenesis. Precursor lesions are characterized by the appearance of dysplastic lesions in the form of microscopic dysplastic foci and macroscopic dysplastic nodules. There are 2 types of small ... (Publication: Archives of Pathology & Laboratory Medicine)
- Clinical Implications of Margin Involvement by Pleomorphic Lobular Carcinoma In Situ
- Abstract: Context.-The appropriate treatment for patients with pleomorphic lobular carcinoma in situ (PLCIS) is unknown. When diagnosed on core biopsy, excision is recommended; however, management of PLCIS when it involves margins has not been addressed. Objective.-To evaluate the significance of PLCIS that ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Context.-The appropriate treatment for patients with pleomorphic lobular carcinoma in situ (PLCIS) is unknown. When diagnosed on core biopsy, excision is recommended; however, management of PLCIS when it involves margins has not been addressed. Objective.-To evaluate the significance of PLCIS that ... (Publication: Archives of Pathology & Laboratory Medicine)
- Collagenous Sprue: A Rare, Severe Small-Bowel Malabsorptive Disorder
- Abstract: Collagenous sprue is a severe malabsorptive disorder, histologically characterized by small intestinal villous and crypt atrophy, and a subepithelial collagen deposit, thicker than 12 m, that entraps lamina propria cellular elements. Collagenous sprue is a rare disease entity, with only about 60 ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Collagenous sprue is a severe malabsorptive disorder, histologically characterized by small intestinal villous and crypt atrophy, and a subepithelial collagen deposit, thicker than 12 m, that entraps lamina propria cellular elements. Collagenous sprue is a rare disease entity, with only about 60 ... (Publication: Archives of Pathology & Laboratory Medicine)
- A Case of Black Esophagus With Histopathologic Description and Characterization
- Abstract: Black esophagus, or acute necrotizing esophagitis, is a blackening of the esophagus that is usually distal with a sharp demarcation at the gastroesophageal border. Black esophagus is known to the gastroenterology community; however, to our knowledge it is virtually unknown in the pathology ... (Publication: Archives of Pathology & Laboratory Medicine)
PubDate: Wed, 01 Jun 2011 00:00:00 -050
- Abstract: Black esophagus, or acute necrotizing esophagitis, is a blackening of the esophagus that is usually distal with a sharp demarcation at the gastroesophageal border. Black esophagus is known to the gastroenterology community; however, to our knowledge it is virtually unknown in the pathology ... (Publication: Archives of Pathology & Laboratory Medicine)
