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     ISSN (Print) 1082-801X
     Published by Advanstar Communications, Inc. Homepage  [9 journals]
  • FDA Evaluates Diabetes Drugs for Possible Increased Risk of Pancreatitis, Precancerous Cellular Changes of Pancreas
    • Abstract: FROM THE LITERATUREDiabetes drugs including exenatide (Byetta, Bydureon), liraglutide (Victoza), sitagliptin (Januvia, Janumet, JanumetXR, Juvisync), saxagliptin (Onglyza, Kombiglyze XR)5 alogliptin (Nesina, Kazano, Oseni), and linagliptin (Tradj enta, Jentadueto) are being evaluated by FDA for a ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Review of the Pharmacologic Arsenal for the War on Obesity
    • Abstract: AbstractObesity has become a highly prevalent chronic condition that is associated with significant morbidity and mortality. Studies have demonstrated that even as little as 5% to 10% of weight loss is associated with an improvement in cardiovascular risk factors and a reduction in the incidence of ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Long-Term Spironolactone Use May Improve Heart Function, but Not Symptoms, QoL for Heart Failure Patients
    • Abstract: from Staff ReportsIn patients with heart failure with preserved ejection fraction, long-term treatment with spironolactone improved left ventricular diastolic function, but didn't affect maximal exercise capacity, patient symptoms, or quality of life (QoL), according to a recent study in JAMA.The ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Pipeline Preview
    • Abstract: Complete response* Proprietary formulation of mannitol (Bronchitol, Pharmaxis) administered as a dry powder in a hand-held inhaler for the treatment of cystic fibrosis. In the complete response letter (CRL), FDA recommended that Pharmaxis conduct an additional clinical trial to obtain an approval ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Use of Anti-TNF Therapies for Inflammatory Diseases Does Not Appear to Increase Risk of Herpes Zoster
    • Abstract: Although patients with rheumatoid arthritis (RA) have a disproportionately higher incidence of herpes zoster, an analysis that included nearly 60,000 patients with RA and other inflammatory diseases found that those who initiated anti-tumor necrosis factor (TNF) therapies were not at higher risk of ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • FDA Actions in Brief
    • Abstract: Tobramycin inhalation powder (TOBI Podhaler, Novartis) 28 mg per capsule was approved for the management of cystic fibrosis patients with Pseudomonas aeruginosa bacteria in the lungs.Rrst Botulism Antitoxin Heptavalent (A, B, C, D, E, F, GEquine) (Cangene) was approved to treat patients showing ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Reduced Rate of COPD-Related Hospitalizations Seen with Long-Term ICS/LABA Combination Therapy
    • Abstract: from Staff ReportsLong-term treatment with fixed-combination budesonide/formoterol (Symbicort Turbuhaler, AstraZeneca) was associated with fewer healthcare utilization-defined exacerbations and hospitalizations than fluticasone/salmeterol in patients with moderate and severe chronic obstructive ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Liraglutide Trial for Obesity Shows Slight Increase in Weight Loss with Higher Dose
    • Abstract: from Staff ReportsPatients with type 2 diabetes achieved 6% weight loss with liraglutide 3 mg in a phase 3a obesity trial, according to Novo Nordisk.This is the second phase 3a trial to be completed as part of SCALE (Satiety and Clinical Adiposity - Liraglutide Evidence in Non-Diabetic and Diabetic ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • New Initiatives Arise out of NECC Compounding Tragedy
    • Abstract: The human toll of the New England Compounding Center (NECC) tragedy continues to grow as the death count is at 50 and the number of patients sickened now exceeds 722. These cases have been reported, and are being tracked by the Centers for Disease Control (CDC) in 20 states. The impact that this ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • CMS Final Sunshine Act Transparency Rule: Managed Care and Hospital Impacts
    • Abstract: On February 1, 2013, the Centers for Medicare & Medicaid Services (CMS) released new regulations about the reporting of fees, meals, travel expenses, and other transfers of value for the implementation of the Physician Payment Sunshine Act (PPSA). These new regulations require that data on the ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • More Research Needed to Quantify the Impact of Copay Cards
    • Abstract: COPAY CARDS and discount programs are an increasingly important part of many pharmaceutical brands' marketing strategy. Yet as copay offset programs have grown more popular, they have become increasingly controversial, as indicated by lawsuits, regulatory changes and backlash from pharmacy benefit ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Update on Taxanes for Prostate Cancer
    • Abstract: FROM THE 2013 GENITOURINARY CANCERS SYMPOSIUMRecent advances in the treatment of metastatic castration-resistant prostate cancer (CRPC) have led to new agents demonstrating overall survival (OS) advantages, including autologous cellular immunotherapy (sipuleucel-T), a new taxane (cabazitaxel), 2 ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Specialty Prescription Drug Spending Hits All-Time High in 2012
    • Abstract: Specialty prescription drugs accounted for almost one-quarter of the US total drug costs within the pharmacy benefit last year - hitting an all-time high, even though fewer than 2% of the population is affected by diseases that require these medications, according to data released by Express ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • New Molecular Entities
    • Abstract: NesinaAlogliptinTAKEDAOseniAlogliptin and pioglitazoneTAKEDAKazanoAlogliptin and metformin HClTAKEDANesina: a new dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes as an adjunct to diet and exercise. Oseni: a fixed-dose combination of alogliptin and pioglitazone. Kazano: ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Higher Long-Term Mortality Risk Seen after Young-Adult Stroke
    • Abstract: from Staff ReportsYoung adults who have had a stroke are at higher risk of long-term mortality compared with expected mortality, according to a report published March 20 in the Journal of the American Medical Association.Researchers from The Netherlands investigated the long-term mortality and ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • Nonbenzodiazepine Sleep Aids Put LTC Residents at Higher Risk for Hip Fracture
    • Abstract: Take awayWhen possible, nonpharmacological interventions should be used to promote sleep rather than drugs.Nursing home residents who use nonbenzodiazepine sleep medications have a 70% increased risk of hip fracture, according to a study online in. JAMA Internal Medicine.Researchers used a ... (Publication: Formulary)
      PubDate: Mon, 01 Apr 2013 00:00:00 -050
       
  • An Update on Attention Deficit/hyperactivity Disorder
    • Abstract: PEER-REVIEWED*AbstractAttention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder in children. Recent guideline changes from the American Academy of Pediatrics (AAP) recommend evaluating and diagnosing children ages 4 to 18 years. Medication therapy for ADHD has been ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Vitamin D Potency Varies Widely in Dietary Supplements
    • Abstract: The potency of vitamin D in compounded and over-the counter (OTC) supplements varied widely, according to a recent research letter published in the February 11 issue di JAMA Internal Mediane.Researchers were conducting a randomized controlled trial of vitamin D in menopausal women. "We used ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Pediatric Treatments for Allergic Ocular Diseases Improve
    • Abstract: FROM THE AMERICAN ACADEMY OF OPHTHALMOLOGY ANNUAL MEETINGRecent advances in treatments of allergic ocular diseases are available to help relieve the signs and symptoms in pediatric patients. Stephen C. Pflugfelder, MD, described those treatments in a symposium during the recent annual meeting of ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Physician Dispensing Costs Triple That of Retail
    • Abstract: Physician dispensing is more expensive than pharmacy dispensing. Sometimes 10 to 20 times more expensive.That's a key finding from the 2012 Survey of Prescription Drug Management from CompPharma, LLC, a consortium of workers' compensation pharmacy benefit managers (PBMs). Physician dispensing and ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Female Sexual Disorders: Treatment Options in the Pipeline
    • Abstract: PEER-REVIEWEDAbstractFemale sexual problems are best conceptualized from a biopsychosocial perspective that includes biological, psychological, sociocultural, and interpersonal factors. Treatment also follows a biopsychosocial model and options include psychotherapy, pharmacotherapy, physical ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Low-Dose Contraceptive Patch Comparable to Combination Oral Contraceptive in Safety, Tolerability Study
    • Abstract: from Staff ReportsA low-dose contraceptive patch is comparable to combination oral contraceptive in a comparative study, according to phase 3 data presented at the American College of Obstetricians and Gynecologists' (ACOG) 60th Annual Clinical Meeting.A once-weekly, low-dose combination ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Drug Manufacturers Seek Payer Feedback on New Products
    • Abstract: Partnering in healthcare seems to be the prevailing wind while achieving access, cost effectiveness, and high quality remains the aim of the industry. It is evident in accountable care organizations, in hospitals buying up physician groups, and large pharmaceutical companies acquiring smaller ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • New Strategies Needed to Reduce Mortality Associated with Cardiometabolic Risk Factors in Young People
    • Abstract: Among US adolescents and young adults, hig h HbA,c levels, central obesity, and smoking were associated with an increased risk of dying before 55 years of age, according a study published recently in Pediatrics."We looked at risk factors for dying before the age of 55 years among adolescents and ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • IOM Report Focuses on Impact of Counterfeit, Substandard Drugs
    • Abstract: A new Institute of Medicine (IOM) report addresses growing concerns in the global community surrounding the public safety matters of fake and substandard drugs."The integrity of the pharmaceutical supply chain continues to be a primary concern in the United States especially in the wake of ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Know Your Options for Cost-Effective Management of HE
    • Abstract: FROM THE AMERICAN COLLEGE OF GASTROENTEROLOGY ANNUAL SCIENTIFIC MEETINGChronic liver disease affects more than 8 million people in the United States. The etiology of chronic liver disease ranges from infections, medications, inheritable disorders, and metabolic- and alcohol-related disease ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Aspirin Use Linked to Age-Related Macular Degeneration
    • Abstract: Regular use of aspirin was associated with a 2-fold greater risk of developing the neovascular subtype of age-related macular degeneration (AMD) than in non-users, according to research reported online 'a JAMA Internal Mediane.Australian researchers' finding of a longitudinal association - with ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Community-Based Intervention Can Help Reduce Mortality from Opioid Overdose
    • Abstract: in a study of communities in Massachusetts with high numbers of opioid overdose deaths, implementation of overdose education and naloxone distribution (OEND) were associated with a significant reduction in opioid overdose death rates.The study was led by researchers at Boston Medical Center (BMC), ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • MS Specialty Drug Treatment Costs Climb to Two-Thirds of Total MS Treatment Cost
    • Abstract: from Staff ReportsMultiple sclerosis (MS) specialty drug costs now account for more than twothirds of MS patients' total cost of care, according to a new study.The study, by pharmacy benefit manager Prime Therapeutics, in collaboration with Blue Cross Blue Shield of Minnesota, found MS specialty ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Patients Who Adhere to Statin Regimens Are Healthier, but Higher Drug Spending Makes Overall Care More Costly
    • Abstract: from Staff ReportsIndividuals with high cholesterol who stay on their statin medications over a 2-year period are healthier than comparable nonadherent individuals, but the overall cost of their care is slightly higher, according to a new study.While the new study, from pharmacy benefit manager ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • CPOE Systems Can Reduce Drug Errors by Almost Half
    • Abstract: from Staff ReportsProcessing a prescription through an electronic ordering system decreases the likelihood of error on that order by 48%, and averts more than 17 million such incidents in US hospitals in 1 year alone, according to research published online in the Journal of the American Medical ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • New Molecular Entity
    • Abstract: SirturoBedaquilineJANSSEN THERAPEUTICSA diarylquinoline antimycobacterial drug indicated as part of combination therapy in adults (> 18 years) with pulmonary multidrug-resistant TB.Late last year FDA approved bedaquiline (Sirturo, Janssen Therapeutics) tablets for the treatment of pulmonary ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Statins Use May Reduce Mortality in Hepatocellular Cancer by 30%
    • Abstract: FROM THE GASTROINTESTINAL CANCERS SYMPOSIUMUse of statins in hepatocellular carcinoma (HCC) patients may be associated with prolonged overall survival, according to a poster session presented at the recent Gastrointestinal Cancers Symposium, in San Francisco.Young Kwang Chae, MD, of the University ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Drug Watch
    • Abstract: A HEADS-UP ON PHARMACEUTICALS IN LATE-STAGE DEVELOPMENTSelected literature* Degludec. Mathieu C, Hollander P, Miranda-Palma ', et al. Efficacy and safety of insulin degludec in a flexible dosing regimen vs insulin glargine in patients with type 1 diabetes (BEGIN: Flex TI): A 26-week randomized, ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • High Calcium Intake Could Raise CV Mortality in Women
    • Abstract: from Staff ReportsA high calcium intake, from diet or the combination of diet and supplements may raise the rate of mortality, especially cardiovascular (C V) mortality, said a study in the British Medkaljournal (BMJ).In an observational cohort study, Swedish researchers followed approximately ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • What to Do about Multidrug-Resistant Gonorrhea
    • Abstract: FROM THE LITERATUREfrom Staff ReportsGonorrhea, caused by the bacterium, Neisseria gonorrhoeae, continues to be a major US public health problem in terms of its prevalence as well as the lack of effective treatments available.Multidrug-resistant gonorrhea is a growing problem that the Centers for ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Researchers Seek Class of Anti-Allergies
    • Abstract: Spring is on the horizon, and with it comes the renewal of seasonal allergies. Lately, though, it seems that while allergy seasons come and go, allergy therapies remain the same. For more than 3 decades, antihistamine-based agents have been the standard of care. Although there have been valuable ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Anti-VEGF Drugs: Not Just for Retinal Pathologies Alone
    • Abstract: FROM THE AMERICAN ACADEMY OF OPHTHALMOLOGY ANNUAL MEETINGUse of anti-vascular endothelial growth factor (VEGF) drugs may be beneficial in patients with neovascular glaucoma and to control complications after filtration surgeries.Many questions remain about their applicability during trabeculectomy, ... (Publication: Formulary)
      PubDate: Fri, 01 Mar 2013 00:00:00 -060
       
  • Bariatric Surgery Can Help, but Not Cure, Diabetes
    • Abstract: Gastric bypass surgery can improve glycémie control in adults with type 2 diabetes, but doesn't cure diabetes, according to the largest community-based study of long-term diabetes outcomes after bariatric surgery, published online ahead of print in Obesity Surgery.The multisite study tracked 4,434 ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Manage Periodontal Disease to Rein in Pharmacy Costs
    • Abstract: A study of 1.7 million patients with diabetes indicates that reducing inflammation of the mouth can produce improvement in other health measures. By controlling periodontal disease, plan sponsors also save on medical and pharmacy costs.The oral health study conducted last year by United Concordia ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Low Back Pain May Be Difficult to Self-Manage, Study Says
    • Abstract: Self-management has small effects on pain and disability in people with low back pain, according to a study published online in Arthritis Care & Research."We found very few trials that tested self-management for low back pain, and in many of the trials we had some concerns about the adequacy of the ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Perampanel: A Highly Selective, Non-Competitive AMPA-Type Glutamate Receptor Antagonist for Adjunctive Treatment of Refractory Partial-Onset Seizures
    • Abstract: AbstractPerampanel is a selective, non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist that is used as an adjunctive therapy for refractory partial-onset seizures. It is the first antiepileptic drug (AED) to target AMPA receptors to control seizure ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • American Academy of Pediatrics: Retain Thimerosal for Global Vaccine Use
    • Abstract: FROM THE LITERATUREThe American Academy of Pediatrics has announced its endorsement of the World Health Organization's (WHO) recommendation that thimerosal not be banned from vaccines.The preservative, which contains ethyl mercury, has been used in some vaccines since the 1930s as an antibacterial ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Positive New JAK2 for Myelofibrosis Shows Promise
    • Abstract: FROM THE AMERICAN SOCIETY OF HEMATOLOGY ANNUAL MEETINGWith limited treatments available, the discovery of mutations in Janus kinase 2 (JAK2) in 2005 was a major step forward for scientists in search of new therapies for myeloproliferative neoplasms (MPNs).MPNs are a group of related disorders in ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Trends in Statin Prescribing in a 4,000-Member Physician-Hospital Organization
    • Abstract: The Advocate Physician Partners (APP) physician-hospital organization (PHO) located in northern Illinois is comprised of 11 hospitals, 500,000 covered lives, and more than 4,000 physician members. In addition to contracting with most major payers, APP became a Medicare Accountable Care Organization ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Medication-Related Adverse Events Tied to ED Visits in the Elderly
    • Abstract: FROM THE LITERATUREAdverse drug events in the elderly can be prevented with appropriate monitoring, according to CDC.Adults aged 65 years and older are twice as likely to visit the emergency department (ED) due to an adverse drug event and 7 times more likely to be hospitalized as a result of the ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Benzodiazepines May Increase Risk of CAP, Mortality
    • Abstract: FROM THE LITERATUREBenzodiazepines, which have been associated with an increased incidence of infections in the critically ill, also may increase the risk of communityacquired pneumonia (CAP) and mortality following pneumonia, according to a recent report published in Thorax.In a case-control study ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Antimicrobial Stewardship Programs: A Review for the Formulary Decision-Maker
    • Abstract: AbstractAntimicrobial stewardship programs (ASPs) are being implemented in various practice settings to assist with the challenges associated with the management of infectious diseases. Although the primary objective of such a program is optimization of clinical outcomes, many potential financial ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • African-Americans More Likely to Die at First Coronary Event
    • Abstract: African- American men and women continue to have higher risks of dying at the first presentation of heart disease compared with their white counterparts, according to a study published in the Journal of the American Medical Association.Researchers from the National Institutes of Health (NIH) ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • Analgesics Linked to Hearing Loss in Women
    • Abstract: Women who regularly took the analgesics Ibuprofen or acetaminophen 2 or more days per week had an increased risk of hearing loss, according to a study published in a recent issue of the American Journal of Epidemiology.This is the first large prospective study of the relation between regular use of ... (Publication: Formulary)
      PubDate: Tue, 01 Jan 2013 00:00:00 -060
       
  • SSRIs Risky during Pregnancy and Affect Neonatal Health
    • Abstract: There is evidence of risk with the use of selective serotonin reuptake inhibitors (SSRIs) during pregnancy and to neonatal health and beyond, according to a study published in Human Reproduction."First, there is clear and concerning evidence of risk with the use of the SSRI antidepressants by ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Early Therapy with Basal Insulin Does Not Reduce Cardiovascular Outcomes in Dysglycemic Patients
    • Abstract: Early initiation of basal insulin did not impact cardiovascular outcomes compared to standard management of glucose in patients with type 2 diabetes or elevated fasting glucose with cardiovascular risk factors. However, there was a significant decrease in incident diabetes among patients treated ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Social Value of Statins Merits Actions to Broaden Treatment, Improve Adherence, Study Finds
    • Abstract: New evidence suggests that statins generate large survival and health benefits at the population level and shows that the social value of the survival gains are large and go predominantly to consumers, according to a study published in a recent issue of Health Affairs."Statins are considered a ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Escitalopram Reduces the Risk of Depression in Patients with HCV Treated with Interferon Alpha
    • Abstract: Pre-emptive therapy with the selective serotonin reuptake inhibitor escitalopram in patients initiating interferon therapy for hepatitis C virus (HCV) without psychiatric risk factors reduced the risk of depression, according to a recent study published in the Annals of Internal Mediane.Interferon ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Stroke Decreases in Elderly, but Rises in Younger Patients
    • Abstract: Stroke is declining in the elderly but increasing at younger ages, according to research published online in Neurology.According to the Greater Cincinnati/Northern Kentucky Stroke Study, a population-based epidemiology study, based on data from Greater Cincinnati and Northern Kentucky, in 1993 to ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Clinical Pharmacists' Partnership with Hospices Drives an Evolution of PBM Services
    • Abstract: AbstractHospice and palliative care organizations provide end-of-life care to more than 1.5 million patients each year. Pharmacists have become an integral part of the hospice interdisciplinary team approach to patient-centered care. While the role of the pharmacist in the healthcare continuum ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • P&T Community Ponders Economic Goals of Healthcare Reform and Pharmacy
    • Abstract: Finally, the grueling election is over and healthcare reform is here to stay. The questions now are: What will happen' When and how will it occur' What effect will it have' And, more specifically, how will it affect those of us in the medication management or pharmacy practice'Many observers ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • A Year of Novel Pharmacologic Agents in Review
    • Abstract: In 2012, 10 newly approved or investigational drugs of interest to pharmacy and therapeutics (P&T) committee members have been the subject of Formulary's "Focus on" articles. The editors have compiled the following review of these agents, along with updates on the regulatory status of each.Many ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Updated Antiplatelet Guideline Highlights Surgical Bleeding Risk
    • Abstract: The Society of Thoracic Surgeons (STS) has updated its clinical practice guideline on use of antiplatelet drugs during heart surgery. The new guideline, published in the November 2012 issue of The Annals of Thoracic Surgery, takes into account newly available antiplatelet therapies, new scientific ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • Ivermectin Lotion Eliminates Head Lice with 1 Application
    • Abstract: Topical ivermectin provided a good degree of cure in patients with head lice infection with 1 simple and easy-to-use application, according to a study published in the November 1 issue of the New England Journal of Medicine.A single application of 0.5% ivermectin lotion (Skiice, Sanofi Pasteur) ... (Publication: Formulary)
      PubDate: Sat, 01 Dec 2012 00:00:00 -060
       
  • New Combination
    • Abstract: TruvadaEmtricitabine/tenofovir disoproxil fumarate tabletsGILEAD SCIENCESA combination of emtricitabine and tenofovir disoproxil fumarate, both nucleoside analog HIV-1 reverse transcriptase inhibitors, for the treatment of HIV-1 infection in adults and pediatric patients aged 12 years and olderFDA ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Bariatric Surgery Associated with Reduction in the Incidence of Type 2 Diabetes
    • Abstract: Bariatric surgery reduces the incidence of type 2 diabetes, according to a recent observational study conducted in Sweden and published in the New England Journal of Medicine.According to the CDC, 35.7% of the US adult population is obese, defined as a body mass index (BMI) of 30 or higher. An ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Pharmacists Must Prioritize Medication Reconciliation
    • Abstract: FROM THE LITERATUREAlthough some general guidance exists on how to best approach medication reconciliation efforts - using pharmacy staff and focusing on patients at high risk for adverse events - ultimately, there is a lack of rigorously designed studies on this topic, and therefore there remains ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Wide Variation Exists in Antibiotic Prescribing for Medicare Patients Based on Geography, Season
    • Abstract: A study of Medicare data suggests there is substantial variation in the use of antibiotics across regions after adjusting for population characteristics, according to a report published "Online First" by Archives of Internal Medicine, a JAMA Network publication."The regional differences did not ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • ICUs Vary in Surveillance, Infection-Control Practices of Multidrug-Resistant Organisms
    • Abstract: Screening practices for multidrugresistant organisms (MDROs) in intensive care units (ICUs) vary widely from hospital to hospital, according to a study published in the October issue of the American Journal of Infection Control, the official publication of the Association for Professionals in ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Depressive Symptoms Are Associated with Opioid Misuse in Patients Treated with Chronic Opioids
    • Abstract: Depressive symptoms are associated with use of opioids for non-pain symptoms, according to researchers from California and Washington state, as is self-increasing the dose or refilling an opioid prescription early in patients treated for chronic pain without a history of substance use disorders.CDC ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Dimethyl Fumarate: A Fumaric Acid Ester under Investigation for the Treatment of Relapsing-Remitting Multiple Sclerosis
    • Abstract: AbstractDimethyl fumarate is an investigational drug being studied for the treatment of relapsing-remitting multiple sclerosis (RRMS). The mechanism of action includes anti-inflammatory action as well as modulation of cellular oxidative response through nuclear-related factor E2-related factor 2 ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • New Healthcare Payment Models to Shape Drug Coverage, Costs, and Expenditures
    • Abstract: Health system payment reform is on the minds of just about everyone involved in healthcare delivery, financing, and analysis. Prescription drugs occupy an interesting place in the debate, as medical technologies offer a means of providing more effective and efficient care, while also serving as ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Disease-Modifying Therapies for Multiple Sclerosis: Focus on Future Direction
    • Abstract: PEER-REVIEWEDAbstractMultiple sclerosis (MS) is a neurologic disorder of chronic inflammation and demyelination of the central nervous system. The disease affects an estimated 400,000 people in the United States, with an onset in young adulthood. The exact cause of MS is unknown; however, both ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • FDA Warns of Serious Blood Disorder Resulting from Abuse of Opana ER
    • Abstract: FDA has warned patients of thrombotic thrombocytopenic purpura (TTP), a serious blood disorder, resulting from misuse of oxymorphone hydrochloride extended-release tablets (Opana ER).FDA recently became aware of TTP that occurred in individuals abusing this pain drug, resulting in kidney failure ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • In Real-World Study, Benefits Outweigh Risk for Restarting Warfarin after Initial GI Bleed
    • Abstract: Patients taking long-term warfarin who had bleeding from their gastrointestinal (GI) tract should probably resume warfarin once the bleeding episode is under control to reduce their risk of thrombosis, according to a study published online in the Archives of Internal Medicine.In this retrospective ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Additional Safety, Tolerability Data for Tivozanib versus Sorafenib in Metastatic RCC Shows Fewer Adverse Events
    • Abstract: FROM THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY 2012 CONGRESSNew data demonstrating the safety and tolerability profile of tivozanib versus sorafenib in the first-line setting for patients with metastatic renal cell carcinoma (RCC), was presented at the European Society for Medical Oncology (ESMO) ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Improve Formulary Adherence through Effective Provider Engagement
    • Abstract: AbstractThe world of formulary management is changing. More than 80% of all prescribed medications are now generic, and the industry has moved to a new value-based reimbursement strategy. Health plans must find more effective ways of communicating with their affiliated physicians so that best ... (Publication: Formulary)
      PubDate: Thu, 01 Nov 2012 00:00:00 -050
       
  • Modifying Antiplatelet Therapy Based on Platelet Function Testing Does Not Improve Outcomes in stroke/TIA Patients
    • Abstract: FROM THE AMERICAN COLLEGE OF CARDIOLOGY ANNUAL SCI ENTI FIC SESSION & EXPO 2012 In the quest to adopt personalized medicine approaches, optimizing antiplatelet therapy based on platelet function testing is controversial. But data from a team led by a researcher at the Cleveland Clinic failed to ... (Publication: Formulary)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Tofacitinib: A Novel Oral Janus Kinase Inhibitor for Rheumatoid Arthritis
    • Abstract: Abstract Rheumatoid arthritis (RA) is a chronic, inflammatory disease characterized by synovial inflammation and destruction of joint cartilage, which afflicts mainly the elderly and women of northern Europe and North America. Disease-modifying antirheumatic drugs (DMARDs), which are further ... (Publication: Formulary)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Incretin-Based Therapies: A Focus on Safety Concerns and Emerging Uses
    • Abstract: Abstract Incretin-based therapies, glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidly peptidases (DPP-4) enzyme inhibitors are a novel class of medications with a multifactorial approach for serum glucose reduction. These therapeutic classes are endorsed by the American College of ... (Publication: Formulary)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Current Standards and Future Treatments of Rheumatoid Arthritis
    • Abstract: PEER-REVIEWED Abstract Rheumatoid arthritis (RA) is an autoimmune disorder in which the immune system targets synovial joints and causes mild-to-severe joint disease with extra-articular manifestations. RA is associated with significant disability and socioeconomic costs because it is estimated to ... (Publication: Formulary)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Take Charge of Medication Reconciliation to Reduce Readmission Rates
    • Abstract: There is substantial variability in hospital practices to reduce readmissions of patients with heart failure (HF) or acute myocardial infarction (AMI), according to a study recently published in the Journal of the American College of Cardiology (JACC), the authors suggest opportunities for further ... (Publication: Formulary)
      PubDate: Mon, 01 Oct 2012 00:00:00 -050
       
  • Hip Fractures Less Likely If Patients Had Cataract Surgery
    • Abstract: Cataract surgery is associated with a decrease in odds of hip fractures, according to an observational study published in the August 1 issue of JAMA. Cataract is a progressive ocular disease associated with aging in which clouding of the lens leads to decreased vision. It is estimated that by age ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Overprescribing Antibiotics in Winter Months Increases Antibiotic Resistance in Community and Hospital Settings
    • Abstract: WHAT'S NEW IN DRUG RESEARCH AND MANAGED CARE PHARMACY Take away Large-scale seasonal overprescribing of antibiotics in the community results in short-term changes in antibiotic resistance both in the community and the hospital, according to a stud}7 published online in Clinical Infectious Diseases. ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Targeting the Incretin System: Novel Advances in the Treatment of Diabetes
    • Abstract: PEER-REVIEWED Abstract Type 2 diabetes mellitus remains a complex and prevalent disease in the United States today. Therapies including sulfonylureas and thiazolidinediones have been effective in its management but their limits in the long term are problematic. Incretin-based therapies are now the ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Formulary Decision Process at Mayo Clinic Leads to Abandoning 80-Mg Dose of Simvastatin
    • Abstract: FROM THE AMERICAN COLLEGE OF CARDIOLOGY ANNUAL SCIENTIFIC SESSION & EXPO 2012 Through the use of its electronic health records (EHRs), a simvastatin prescribing guide was implemented at the Mayo Clinic in response to FDA's recommendation to limit the use of the 80-mg dose of the drug. A formulary ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Former Finasteride Users with Sexual Side Effects at Increased Risk for Depressive Symptoms, Suicidal Thoughts
    • Abstract: A significant number of men who developed persistent sexual side effects from taking finasteride (Propecia and Proscar) also suffer from depressive symptoms and suicidal thoughts, according to a stud}7 published online in the Journal of Clinical Psychiatry. Finasteride is a commonly prescribed ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • An Evidence-Based Review of Treatment Options for Irritable Bowel Syndrome
    • Abstract: PEER-REVIEWED Abstract Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and altered bowel habits with a duration of at least 3 months. IBS is prevalent, expensive to treat, and is associated with significantly impaired health-related quality ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Teduglutide: A Novel Recombinant Analog of Human Glucagon-Like Peptide-2 for Short Bowel Syndrome
    • Abstract: Abstract Teduglutide is a recombinant analog of human glucagon-like peptide-2 that is awaiting FDA approval for the treatment of short bowel syndrome (SBS) as a once-daily subcutaneous injection. It has been shown to slow gastric emptying, reduce gastric secretions, increase intestinal blood flow, ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Statin Use May Be Linked to Increased Cataract Risk
    • Abstract: FROM THE LITERATURE Individuals taking statins are at higher risk of developing cataract at an earlier age than those not taking them, according to a study published in the August issue of Optometry and Vision Science, the official journal of the American Academy of Optometry. "There is an ... (Publication: Formulary)
      PubDate: Sat, 01 Sep 2012 00:00:00 -050
       
  • Delayed Diagnosis, Noncompliance, Lack of Communication, Linked to Hindering HIV Care, IOM Reports
    • Abstract: Delayed diagnosis, noncommunication among HIV care providers, and delayed access to support services are among several barriers to HIV care in the United States, according to a report from the Institute of Medicine (IOM). IOM's Monitoring HIV Care in the U.S.: Indicators and Data Systems comes at a ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • Few Americans Attain CV Health Goals Associated with Decreased Mortality
    • Abstract: Meeting a greater number of guidelinespecified cardiovascular (CV) health goals was associated with a lower risk of total and CV mortality. Unfortunately, the proportion of Americans meeting these goals is bw, according to a recent study published online in JAMA. CV disease is the leading cause of ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • Cetuximab as an Add-On to Leucovorin, Fluorouracil, and Oxaliplatin for Stage 3 Colon Cancer Adds No Benefit
    • Abstract: A large randomized multicenter study found no benefit to adding cetuximab (Erbitux) to the standard adjuvant therapy for resected stage 3 colon cancer, according to a study published inJAMA. The randomized trial involved 2,686 patients aged 18 years or older at multiple institutions across North ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • New Formulation
    • Abstract: Pertzye Pancrelipase delayed-release capsules DIGESTIVE CARE, INC. A combination of porcine-derived lipases, proteases, and amylases for the treatment of exocrine pancreatic insufficiency (EPI) On May 18, 2012, FDA approved pancrelipase delayed-release capsules (Pertzye, Digestive Care, Inc.) for ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • New Oral Anticoagulants for Stroke Prevention in Atrial Fibrillation: An Update for Managed Care and Hospital Decision-Makers
    • Abstract: PEER-REVIEWED Abstract Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and a potent risk factor for stroke. AF-related stroke represents a significant economic burden, with an estimated $8 billion in direct annual costs. The new oral anticoagulants have several advantages ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • HCV Screening Projected to Save 120,000 Boomers' Lives
    • Abstract: Baby boomers may soon add hepatitisC (HCV) to their list of routine annual screenings along with colorectal cancer, cholesterol, osteoporosis, and cervical cancer, when a proposed expansion of current Centers for Disease Control and Prevention (CDC) guidelines is put into place. CDC's proposed ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • FDA Warns of Seizure Risk for Multiple Sclerosis Patients Who Take Dalfampridine
    • Abstract: FROM THE LITERATURE On July 23, 2012, FDA announced a safety communication regarding the risk of seizures in patients with multiple sclerosis (MS) starting dalfampridine (Ampyra). Ampyra was approved by FDA in 2010 to improve walking in patients with MS. The safety communication stemmed from a ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • Carfilzomib: A Second-Generation Proteasome Inhibitor for the Treatment of Multiple Myeloma
    • Abstract: Abstract The introduction of the immunomodulatory drugs and bortezomib, a proteasome inhibitor, has dramatically improved outcomes in patients with relapsed or refractory multiple myeloma. The disease remains incurable, however, and several novel agents are currently in development to address this ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • FDA User Fee Legislation Speeds Drug Approvals, Addresses Shortages, Counterfeits
    • Abstract: It was a pleasant surprise when leading legislators reached across party lines in June to quickly approve the FDA Safety and Innovation Act (FDASIA). The bill (S. 3187), which President Obama signed into law last month, enables FDA to collect some S 6 billion in fees over the next 5 years from ... (Publication: Formulary)
      PubDate: Wed, 01 Aug 2012 00:00:00 -050
       
  • Rising Costs Due to Behavior-Driven Conditions Significantly Impact Health Plan Costs, Report Says
    • Abstract: The rising cost of specialty drugs, challenges with medication adherence, and the utilization of mail order are among the top trends impacting employers and other health plan sponsors, according to a recent report about prescription benefit management trends. According to Express Scripts' fifth ... (Publication: Formulary)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • New Agents Offer Promise for Patients with Hepatitis C, Real-World Study Indicates
    • Abstract: Telaprevir (Incivek, Vertex) and boceprevir (Victrelis, Merck) may offer a more promising future to patients with the hepatitis C genotype 1 infection when combined with the previous regimen of peginterferon alfa and ribavirin, according to emerging research data reported in Atlantic Information ... (Publication: Formulary)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Payers Seek More Comparative Research Documenting Value and Affordability of High-Cost Therapies
    • Abstract: While scientists and biomedical researchers at the recent meeting of the American Society of Clinical Oncology (ASCO) applauded encouraging data on dozens of breakthrough cancer therapies, analysts pondered strategies for convincing payers to cover the new life-saving drugs. More than 900 cancer ... (Publication: Formulary)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • Gain a Solid Understanding of Compendia and Its Impact on Patient Access
    • Abstract: Abstract The current compendia landscape, though constantly in flux, impacts everything from payer approval of off-label use to manufacturer patient access initiatives. Drug compendia, defined as summaries of drug information, affects coverage and reimbursement decisions for pharmaceutical ... (Publication: Formulary)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
  • FDA: Reduce Cefepime Dose in Patients with Renal Impairment
    • Abstract: FDA issued a statement reminding healthcare professionals about the need to adjust the dosage of the antibacterial drug cefepime (Maxipime, Elan) inpatients with renal impairment. Cefepime may cause a specific type of seizure called nonconvulsive status epilepticus, primarily in patients with renal ... (Publication: Formulary)
      PubDate: Sun, 01 Jul 2012 00:00:00 -050
       
 
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