JournalTOCs

Followed Journals

Journal you Follow: 0

Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Jurnals are published.
Already have an account? Sign In to see the journals you follow.

Most Followed Journals

Top Publishers

Top Subjects

Wiley Interdisciplinary Reviews : Membrane Transport and Signaling Follow
Full-text available via subscription

Subscription journal
ISSN (Online) 2190-4618
Published by John Wiley and Sons

[1589 journals]

Issue information
The P2Y receptors and thrombosis
- Abstract: Blood platelets play a key role in arterial thrombosis which is one of the leading causes of mortality in western countries. They may also be involved in the pathogenesis of deep vein thrombosis. Adenosine 5′‐diphosphate (ADP) is one of the most important mediators of platelet activation. Two G protein‐coupled ADP receptors, P2Y1 and P2Y12, selectively contribute to platelet aggregation and formation of a thrombus. Playing a central role in platelet activation and in growth and stabilization of a thrombus, the P2Y12 receptor is an established target of antithrombotic drugs like the thienopyridines clopidogrel or prasugrel, or direct reversible antagonists such as ticagrelor or cangrelor. Each of these drugs has proven efficacy in large clinical trials. At a preclinical stage, studies in P2Y1 deficient mice and using selective P2Y1 antagonists in experimental models of thrombosis and inflammation have shown that this receptor is also an attractive target for new antithrombotic compounds. WIREs Membr Transp Signal 2013. doi: 10.1002/wmts.97 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.
The sugar phosphate/phosphate exchanger family SLC37
- Abstract: The solute‐carrier (SLC) superfamily is divided into 55 different families of genes coding for integral membrane proteins, which transport not only all kinds of endogenous solute substrates, but also exogenous drugs and chemicals. The SLC37 transporters are members of the organophosphate:Pi antiporter family (OPA) and therefore they belong to the major facilitator superfamily (MFS). The SLC37 family members diverged early in evolution. SLC37A1 and SLC37A2 transporters are closely related and they have 57% of identical amino acids, while they have an average of 31% identical amino acids with SLC37A3. SLC37A4 is however quite different from them, sharing an average of 15% identity with the other three members. The SLC37A4 gene (also known as glucose‐6‐phosphate transporter, G6PT) is mutated in the glycogen storage disease non‐1A type, therefore it is well studied both at the DNA and protein levels. Major function of SLC37A4 is to preserve interprandial glucose homeostasis. Data on SLC37A1 and SLC37A2 genes expression are available both in humans and in mice, but there is still little information on their protein function. Even if they are homologous to glycerol‐3‐phosphate transporters, they were described to transport glucose‐6‐phosphate; therefore, they might be multisolute carriers. SLC37A3 is still poorly investigated and the only described feature is that it seems not to transport glucose‐6‐phosphate. WIREs Membr Transp Signal 2013. doi: 10.1002/wmts.98 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.
P2X receptor signaling in skeletal muscle health and disease
- Abstract: Skeletal muscle (SM) is a heterogeneous and dynamic tissue that changes significantly in its form and function in response to external and internal stimuli and throughout life, from development right through to aging. The fully differentiated SM fiber is a highly specialized, complex and metabolically active cell containing finely tuned assemblies of contractile force‐generating proteins, while its growth and repair are maintained by a resident stem cell population. There is increasing evidence that extracellular ATP (ATPe) released during physiological activity and acting on P2 purinoceptors is involved in a number of muscle functions. Furthermore, very high levels of ATPe released from injured muscles can trigger further damage either by altered activation of P2 purinoceptors on muscle cells or by promoting inflammatory cell infiltration. Therefore, the effects of activation of specific P2 purinoceptors in SM can vary from physiologically beneficial to pathologically catastrophic. The most studied in SM so far have been the P2X purinoceptors, which are a family of homo/heterotrimeric ATP‐gated ion channels comprised of seven subtypes. Of these P2X1, P2X2, P2X4, P2X5, P2X6, and P2X7 have been identified, so far, predominantly in mouse SM and shown to influence cell growth, differentiation, death, and regeneration in health and disease. There is, however, a considerable diversity in expression of these receptors between different muscle groups and fiber types, which is not fully recognized yet. Understanding the roles of specific P2X purinoceptors in the physiology and pathology of different muscle groups might offer new opportunities for targeted pharmacological intervention in SM diseases. WIREs Membr Transp Signal 2013. doi: 10.1002/wmts.96 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.
Solute carrier family SLC41: what do we really know about it'
- Abstract: The 41st family of solute carriers (SLC41) comprises three members A1, A2, and A3, which are distantly homologous to bacterial Mg2+ channel MgtE. SLC41A1 was recently characterized as being an Na+/Mg2+ exchanger (NME; a predominant cellular Mg2+‐efflux system). Little is known about the exact function of SLC41A2 and SLC41A3, although, these proteins have also been linked to Mg2+ transport in human (animal) cells. The molecular biology (including membrane topology, cellular localization, transcriptomics, and proteomics) of SLC41A2 and SLC41A3 compared with SLC41A1 has only been poorly explored. Significantly more data with regard to function, functional regulation, involvement in cellular signaling, complex‐forming ability, spectrum of binding partners, and involvement in the pathophysiology of human diseases are available for SLC41A1. Three recent observations namely the identification of the null mutation, c.698G>T, in SLC41A1 underlying the nephronophthisis‐like phenotype, the recognition of a putative link between SLC41A1 and Parkinson's disease, and the observation that nearly 55% of preeclamptic placental samples overexpress SLC41A1, marks the protein as a possible therapeutic target of these diseases. A potential role of the SLC41 family of Mg2+ transporters in the pathophysiology of human diseases is further substantiated by the finding that SLC41A3 knockout mice develop abnormal locomotor coordination. WIREs Membr Transp Signal 2013. doi: 10.1002/wmts.95 Conflict of interest: The authors have declared no conflicts of interest for this article. For further resources related to this article, please visit the WIREs website.