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Journal Cover   Acta Medica Academica
  [2 followers]  Follow
    
  This is an Open Access Journal Open Access journal
   ISSN (Print) 1840-1848 - ISSN (Online) 1840-2879
   Published by Academy of Sciences and Arts of Bosnia and Herzegovina Homepage  [1 journal]
  • Osteoarticular complications of brucellosis: The diagnostic value and
           importance of detection matrix metalloproteinases

    • Authors: Maida Šiširak, Mirsada Hukić
      First page: 1
      Abstract: Objectives. Matrix metalloproteinases (MMPs) has been implicated in the pathogenesis of infective, cancer and autoimmune diseases. In this study, we investigated the serum level of MMPs and its clinical importance in human brucellosis. Patients and methods. This study included 60 brucellosis patients treated at the Clinic for Infectious Diseases, Clinical Centre, University of Sarajevo. Matrix metallopro- teinases serum levels were quantifed by ELISA. Results. The investigation involved three groups: 30 patients with complications, 30 patients without complications of brucellosis and 30 healthy control examinees. The complications of human brucellosis varied but osteoarticular involvement dominated (n=21/30; 70%). Matrix metalloproteinases serum levels in the patients with complications were high est. The serum level of MMP-1 in patients with complications was the highest at 9.45; in patients without complications it was 3.78 and in the control examinees it was lowest at 3.62 (p=0.001). Te serum level of MMP-9 in patients with complications was the highest at 105.66; in patients without complications 64.67, and in the control examinees it was lowest at 37.32 (p=0.001). Te serum level of MMP-13 in patients with complications was highest at 138.86; in patients without complications at 64.85; and in the control examinees it was the lowest at 29.55 (p=0.001). Pearson’s coefcient showed a statistically signifcant positive correlation between levels of tested matrix metalloproteinases and development complications in human brucellosis (p=0.001). Conclusion. Tis study showed the diagnostic value and importance of detection of matrix metalloproteinases in human brucellosis. MMPs are a useful serum biomarker for assessment of disease activity.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Methicillin-resistant Staphylococcus aureus in North-east Croatia

    • Authors: Tajana Pastuović, Magdalena Perić, Zinka Bošnjak, Nataša Ružman, Patricia Reisz Majić, Jasminka Talapko, Vlasta Atalić, Snježana Loci-Zvocak, Dubravka Vuković
      First page: 10
      Abstract: Objective. The aim of this 5-year study was to determine the frequency and antibiotic susceptibility of methicillin-resistant Staphylococcus aureus (MRSA)-related infections at Osijek Clinical Hospital. Materials and methods. A total of 1987 staphylococci-infected clinical isolates were collected and analysed at the Microbiology Department of the Public Health Institute of Osijek-Baranja County. Results. Be- tween 2008 and 2012, the average rate of MRSA-related infections in staphylococci-infected patients was 27.4%. The proportion of MRSA- related infections on all Staphylococcus aureus (S. aureus) isolates from clinical specimens showed a decreasing trend, from 32.6% in 2008 to 25.5% in 2012. MRSA-related infections were mostly detected in wound swabs (50.6%) and aspirates (28.8%) of patients hospitalized in the surgical (49.8%) and intensive care units (27.9%). MRSA-relat- ed infection showed an increase compared to S. aureus-infections in samples of wounds and aspirates in 2011 and 2012 (57.9%/34.9% and 35.2%/16.3%, respectively). The majority of strains of MRSA-related infections were resistant to several antibiotics, including erythromycin and clindamycin, where susceptibility were less than 10%. All MRSA isolates were susceptible to vancomycin, teicoplanin and linezolid. Therefore, antibiotic therapies for MRSA infections include vancomycin, teicoplanin and linezolid, but microbiological diagnostics need to be performed in order to know when the use of glycopeptides and oxazolidinones is indicated. Conclusion. Our results suggest that appropriate prevention measures, combined with the more rational use of antibiotics are crucial to reduce the spread of MRSA-related infection in healthcare settings. Further monitoring is necessary of the incidence and antibiotic susceptibility of MRSA-related infections in our community.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • National survey of pain clinics in Croatia: Organization and services

    • Authors: Mahir Fidahić, Katarina Dogan, Damir Sapunar, Livia Puljak
      First page: 18
      Abstract: Objective. To analyze organization and therapeutic procedures ad- ministered in tertiary outpatient pain clinics in Croatia. Methods. Data about organization of pain clinics, its personnel, equipment, continuing medical education, therapeutic procedures, research activities and relations with pharmaceutical industry were collected using questionnaires. Results. Twenty-two Croatian pain clinics were included in the study. Most of the pain clinics employ exclusively anesthesiologists and nurses. The most frequently prescribed therapeutic procedures in pain clinics were pharmacotherapy, transcutaneous electrical nerve stimulation, acupuncture and trigger point injections. Almost all pain clinics provide educational material for patients. Most of the pain clinics have regular interactions with pharmaceutical companies. Prescribing decisions were based mostly on information from scientific meetings, research articles and consultations with colleagues. In- formation sources which are considered to be the gold standard – the systematic reviews of The Cochrane Collaboration – were used less frequently (n=12; 57%) than advertising materials from pharmaceutical companies (n=16; 76%). Few physicians and other pain clinics staff had scientific degrees or academic titles or were involved in a research project. Conclusion. The national study about pain clinics in Croatia pointed out that there is room for improvement of their organization and services. Pain clinics should employ health-care professionals with diverse backgrounds. They should offer treatments backed by the highest-level of scientific evidence. Since pain is a major public health issue, pain clinic staff should engage more in research to contribute to the growing field of pain research, to enhance capacities for pain research in Croatia, to incorporate scientific evidence into their daily decision-making and to enable evidence-based practice.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Morphological and morphometric analysis of the shape, position, number and
           size of mental foramen on human mandibles

    • Authors: Alma Voljevica, Elvira Talović, Aida Hasanović
      First page: 31
      Abstract: Objective. To provide anatomical information on the position, morphological variations and incidence of mental foramen (MF) and accessory mental foramen (AMF) as they are important for dental surgeons, anesthetists in nerve block and surgical procedures, to avoid injury to the neurovascular bundle in the mental foramen area. Methods. Our study was conducted on 150 adult dry human mandibles from the osteological collection of the Department of Anatomy of the Faculty of Medicine, University of Sarajevo. The location and shape of the MF and the presence of the AMF were studied by visual examination. The size and position of the MF were measured using a digital vernier caliper. SPSS, version 17 software was used for the statistical analysis. Results. Bilateral mental foramina were presented in all 150 mandibles. In the majority of mandibles, the MF was located between the first and second premolar (20.3%) or on the level of the root of the second premolar (60.3%), midway between the inferior margin and the alveolar margin of the mandible. Most of the mental foramina were oval in shape (83.3%). An AMF was present in four mandibles (2.7%) on the right side. Conclusion. Tis study may be a very useful new supplement to data on variations in the incidence, position, shape and size of mental and accessory mental foramina, which may help surgeons, anaesthetists, neurosurgeons and dentists in carrying out surgical procedures successfully.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Tumor marker CA 15-3 in breast cancer patients

    • Authors: Hanifa Fejzić, Svjetlana Mujagić, Sanida Azabagić, Mensura Burina
      First page: 39
      Abstract: Objective. The aim of this study was to determine whether there is a correlation between the serum concentration of the tumor marker CA 15-3 and breast cancer, which has not been proven by the existence of regional and distant metastases, and breast cancer with the presence of regional and distant metastases. Patients and methods. The study was a retrospective-prospective study, and was conducted on 100 women aged 40-70 years of age in the period of January 2007 until June 2011, in whom, after surgery, breast cancer was histologically verified, where before the surgery serum tumor marker CA 15-3 levels were established. The serum tumor marker CA 15-3 concentrations are determined in all patients after radiological diagnosis of  suspected breast cancer (radiological findings concluded as BI RADS 4 and 5). The study excluded patients with liver cirrhosis, liver cancer and lung cancer. The study group consisted of patients with metastatic breast cancer, and the control group of patients with breast cancer comprised those shown to be without verified metastatic disease. To calculate the correlation, Spearman’s correlation coefficient was used. A difference in p values of less than 0.05 (p<0.05) was considered statistically significant. Results. The serum tumor marker CA 15-3 was elevated in all patients with proven remote or clubbing metastasis in 35.5% of patients with metastasis spreading to regional lymph nodes. Conclusion. There is a significant correlation between serum concentrations of the tumor marker CA 15-3 and the presence of metastasis, and serum concentrations of tumor markers and the dissemination of the underlying disease.  
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Understanding wider environmental influences on mentoring: Towards an
           ecological model of mentoring in academic medicine

    • Authors: Dario Sambunjak
      First page: 47
      Abstract: Mentoring is a complex developmental relationship that contributes to individual growth and career advancement in different areas of human activity, including academic medicine. Tis article describes a broader environmental milieux in which mentoring occurs and considers the ways in which the environmental factors may affect the process and outcomes of mentoring. An ecological model of mentoring is proposed that takes into account various factors broadly operating at three contextual levels. The first is societal or “macro” level, which implies cultural, economic, and political factors. The second is institutional or “meso” level, consisting of a) system-related factors such as field and discipline characteristics, and government policies, and b) organization-related factors such as mentoring climate, reward structure, and work design. The third contextual level relates to intra- personal and interpersonal characteristics of mentor-mentee dyads. If mentoring dyad is viewed as the focal point, societal and institutional levels may be labeled as “external”, and personal level as “internal”. The conceptual diversity and methodological challenges in the study of mentoring need to be acknowledged, but should not be an excuse to leave the external contextual elements out of the researchers’ horizon, as they inevitably shape and modify the mentoring relationships. Conclusion.  Model presented in this article offers a holistic view of mentoring in academic medicine that may help one comprehend and appreciate the complexity of infuences on mentoring, and inform the future research agenda on this important topic,
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Cochrane and its prospects in Bosnia and Herzegovina: Relying on Cochrane
           Croatia

    • Authors: Mersiha Mahmić-Kaknjo, Livia Puljak, Filipa Markotić, Mahir Fidahić, Lejla Muhamedagić, Irena Zakarija-Grković
      First page: 58
      Abstract: In this article we describe Cochrane and its products: Cochrane systematic reviews (CSRs) and other Cochrane evidence. Cochrane is a unique, international, non-profit organization that offers health care providers, health care consumers and other decision makers unbiased and highly reliable information on health, which is pivotal for conscientious and responsible decision making in overall healthcare. Cochrane offers the highest ranked evidence in Evidence Based Medicine (EBM) – systematic reviews. Currently, CSRs are freely available in BH, and therefore, they ought to be widely used, and understood. We will present the new Cochrane Strategy to 2020, which was the main topic of the 6th Croatian Cochrane Symposium (CroCoS), as well as explore prospects for spreading Cochrane activities to Bosnia and Herzegovina (BH), through collaboration with Cochrane Croatia. BH has no officially organized Cochrane activity, as yet. We hope that this article will raise awareness about Cochrane in BH, help promote its activities, and deepen the existing collaboration with Cochrane Croatia. There are already some changes being introduced concerning Cochrane – at least, in one half, the Federation of BH (FBH). Two documents symbolizing official recognition of policy changes towards Cochrane have recently been published in the Official Gazette of FBH. Conclusion. Since founding a BH Cochrane Branch would be costly and difficult to achieve in a complicated environment, such as the one we have, BH could use the good will, experience, knowledge, and translated educational, training and web materials of Cochrane Croatia, particularly given the language similarities, to promote evidence based medicine in BH. 
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Postgraduate studies (1978-1985) at the Medical faculty of the University
           of Tuzla, Tuzla, Bosnia and Herzegovina

    • Authors: Husref Tahirović
      First page: 68
      Abstract: The Postgraduate studies (PS) at the Medical Faculty (MF) of the University of Tuzla (UT) were founded with the aim of training future staff of the MF in scientific research work. The course lasted four semesters. Up to 1986, classes were attended by five generations or 141 postgraduate students, and 57 of them received their Master’s degree (MSc’s). Classes were held every week on Fridays and Saturdays. One part of the classes was taught at the MF in Szeged (Hungary). Besides teachers from the UT, classes were also taught by teachers from other universities from the former Yugoslavia and abroad. The most important textbooks were: Cell and Molecular Biology by de Robertisa, Mathematics and statistics for use in pharmacy, biology, and chemistry by Saunders & Fleming, and Kako se pišu saopštenja o medicinskim istraživanjima (How to write reports of medical research) by Rajko Igić. Searching the index base Pub Med at the end of 2014, by the surnames and initials of the names of the 57 masters, we found that they had published 14 articles before completing their MSc’s and 821 articles after completing their Master of Science. Later, 35 masters received PhDs and were appointed assistant professors, and later they were also appointed to higher ranks. Conclusion: Looking at the results of the PS, MF of the UT in the above mentioned period, it can be said that the PS was the place where the formation began of the future scientifc and teaching staff of the MF in Tuzla.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Cross-cultural common denominators of the mentoring in biomedicine

    • Authors: Matko Marušić
      First page: 75
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Mentoring in academic medicine: A challenging yet rewarding endeavour

    • Authors: Genc Burazeri
      First page: 77
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Mentoring – hard and underappreciated but rewarding

    • Authors: Suzana Marusic
      First page: 79
      Abstract: No abstract avilable.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • When to start with science teaching in academic medicine'

    • Authors: Mevludin Hasanović
      First page: 81
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Overcoming the impeding influences of institutional and social factors in
           the mentoring process

    • Authors: Tina Poklepović Peričić
      First page: 83
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • Antibiotics that target mitochondria effectively eradicate cancer stem
           cells, across multiple tumor types: Treating cancer like an infectious
           disease

    • Authors: Bogdan Bošković
      First page: 85
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
  • International publications of authors from Bosnia and Herzegovina in
           Current Contents indexed publications in the second half of 2014

    • Authors: Nerma Tanović
      First page: 87
      Abstract: No abstract available.
      PubDate: 2015-06-09
      Issue No: Vol. 44, No. 1 (2015)
       
 
 
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