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Journal Cover UBC Medical Journal
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  This is an Open Access Journal Open Access journal
   ISSN (Print) 1920-7425 - ISSN (Online) 1920-7417
   Published by UBC Homepage  [4 journals]
  • The role of BDNF in Huntington’s Disease: A Targeted Analysis of 12
           Microarray Studies

    • Authors: Ronald Xie, Sharon Yang, Felix Ma, Eric Yang Zhao
      Pages: 17 - 22
      Abstract: ObjectivesHuntington’s disease (HD) is a common hereditary neurodegenerative disorder. Pathogenesis is strongly associated with mutation of the protein huntingtin (HTT). This study focuses on the REST/BDNF pathway and provides statistical analysis on expression levels of many genes involved in this pathway in HD and normal subjects.Methods12 recent microarray studies were systematically selected from the Gene Expression Omnibus (GEO). Over-representation analysis was performed on all assayed genes using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Detailed analysis of genes involved in BDNF expression, delivery, and response was performed and Fischer’s combined probability test was applied to combine findings across the 12 selected studies.ResultsOur findings suggest down-regulation of BDNF expression in HD-affected compared to controls. Analysis of the gene expressions of REST and AKT2 suggests that BDNF expression may be correlated negatively with REST expression and positively with AKT2 expression.ConclusionsThe changes in BDNF expression in HD suggest that impairment of the expression, delivery, and downstream effects of BDNF may play a role in HD pathogenesis.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • Temporal Changes in Multiple Sclerosis onset age: Importance of
           Controlling for Equal Observation Time

    • Authors: Mihaela Dana Pirvoaica, Elaine Kingwell, Afsaneh Shirani, Feng Zhu, Yinshan Zhao, John D. Fisk, Virender Bhan, Robert Carruthers, Ruth Ann Marrie, Helen Tremlett
      Pages: 23 - 26
      Abstract: : Background: Previous studies have examined whether changes in the age at multiple sclerosis (MS) onset have occurred over time, but findings have been inconsistent.Objective: We investigated temporal trends in MS onset age in three Canadian provinces, and assessed the effect of controlling for equal observation time between birth year groups. Methods: We included 9459 MS patients from MS clinic databases housed inBritish Columbia (BC, 5423),Manitoba (MB, 1419) andNova Scotia (NS, 2617). Birth years were grouped into five-year blocks and analysed via ANOVA and linear regression to assess temporal trends in onset age. The complete cohort included all MS patients. The restricted cohort allowed comparable observation times for each birth year group and included patients who had reached age 40 and had MS onset at age 40 or younger.Results: The complete cohort showed a steep decline in onset age (averaging 2.0 years between birth year groups), from 37.0±10.8 years (1941-1945 births) to 28.0±6.4 years (1966-1970 births), p<0.001. In the restricted cohort (n=6003), only BC patients showed a significant decrease in the mean onset age (averaging 0.3 years between birth year groups): 29.6±6.5 years (1941-1945 births) and 27.4±5.8 years (1966-1970 births), p<0.001. No significant decrease in onset age was evident in the NS or MB restricted cohorts.Conclusion: If the age at MS symptom onset has changed in the last four decades, shifts have been rather small. Temporal changes in age at MS onset between birth cohorts can be inflated without due consideration to comparable observation time.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • Resolution of Acquired von Willebrand Disease Secondary to Hypertrophic
           Obstructive Cardiomyopathy Following Septal Myectomy.

    • Authors: Johnathan Hoggarth, Harry Rakowski, Erik Yeo, Anthony Ralph-Edwards
      Pages: 32 - 33
      Abstract: We report the case of a patient with hypertrophic obstructive cardiomyopathy, severe gastrointestinal bleeding and acquired von Willebrand syndrome. Pre-operative blood tests showed normal von Willebrand factor activity with decrease of high molecular weight multimers. Septal myectomy was performed in treatment of his hypertrophic disease. Follow-up blood tests indicated normal von Willebrand factor activity and high molecular weight multimers levels. Gastrointestinal bleeding has not recurred following surgery. In conclusion, septal myectomy resolves von Willebrand syndrome secondary to hypertrophic obstructive cardiomyopathy. von Willebrand factor Multimer testing can be used for the diagnosis of acquired von Willebrand syndrome which should be considered in patients who have gastrointestinal bleeding coinciding with hypertrophic obstructive cardiomyopathy.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • The resurrection of psychedelic psychiatry and its role in addiction

    • Authors: Rachel Skocylas
      Pages: 38 - 39
      Abstract: Psychedelic psychiatry, a field which was previously popular between 1950-1970, has recently received a renewed interest as several recent studies have highlighted the potential role of hallucinogens in the treatment of addictions and various mental illnesses. This paper looks at evidence supporting the use of LSD, ibogaine and ayahuasca to treat various addictions and discusses the barriers to further exploration of the therapeutic potential of psychedelic substances.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • Tackling Social Isolation and Loneliness in Community Exercise Programs
           for Seniors

    • Authors: Jiyoung Hwang, Lisa Wang, Charlotte Jones
      Pages: 40 - 41
      Abstract: Social isolation is a growing problem in Canadian seniors. Social isolation and loneliness are related to negative health effects and increased morbidity and mortality. The majority of senior recreation programs and studies surrounding them focus on physical benefits, while ignoring the effects of the programs on social isolation and loneliness. Furthermore, not many community programs in Canada currently incorporate socialization sessions into exercise programs. This article attempts to highlight studies that focus on tackling the issue of social isolation and loneliness in traditional community senior exercise programs and the potential role of sustained socialization-based exercise programs on improving senior’s health.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • I Would Tell You If I Could: Language Loss, Depression, and the Challenge
           of Treatment with Aphasia

    • Authors: Megan Morrison
      Pages: 42 - 43
      Abstract: : People with aphasia are prone to developing depression, yet their ability to benefit from traditional psychotherapy is reduced, due to the communication challenges associated with their language disorder. This commentary describes the unique cognitive interaction between aphasia and mental illness, and then offers some evidence-based communication strategies, such as Supported Conversation for Adults With Aphasia, which can help facilitate the therapy process for people with aphasia who are also seeking treatment for mental illness. 
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • Concussion and Mental Health: A Concise Review

    • Authors: Alvin H. Ip
      Pages: 44 - 45
      Abstract: N/A
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • The Lasting Effects of Childhood Trauma on Mental Health in Adulthood:
           Current Knowledge and Practical Next Steps for Clinical Practice

    • Authors: Stephanie Lake
      Pages: 46 - 47
      Abstract: N/A
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
  • Burnout and Mental Illness Among Canadian Physicians

    • Authors: Alan Rheaume
      Pages: 48 - 49
      Abstract: In Canada, a growing number of physicians struggle with burnout and mental illness—alone and without treatment.  Fear of stigma and discrimination deters many physicians from seeking help, which has devastating consequences for the health of doctors, patients, and society.  Confronting systemic issues of physician health in medicine will require a collective effort from all areas of health care and governance.
      PubDate: 2017-05-31
      Issue No: Vol. 8, No. 1 (2017)
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
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Fax: +00 44 (0)131 4513327
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