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UBC Medical Journal
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Open Access journal
ISSN (Print) 1920-7425 - ISSN (Online) 1920-7417
Published by University of British Columbia
[2 journals]
Follow ISSN (Print) 1920-7425 - ISSN (Online) 1920-7417
Published by University of British Columbia
[2 journals]- Talking Cancer Genomics, Treatment, and Research with Dr. Torsten Nielsen
- Authors: Maurice Agha
Abstract: NOTE: no abstract required
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Maurice Agha
- Case-Based Teaching in Undergraduate Medical Education and the Perception of Prejudice
- Authors: Eric Yoshida
Abstract: none
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Eric Yoshida
- Low Carb Diets - Sometimes Just as Sweet As They Sound
- Authors: Michael Anthony Benusic
Abstract: n/a
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Michael Anthony Benusic
- Direct-to-Consumer Genetic Testing: Profile of 23andMe
- Authors: Kiran Dhillon
Abstract: N/A
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Kiran Dhillon
- The Hurdled Race Toward Personalized Medicine: the Study of Pharmacogenomics. An interview with Dr. Stan Bardal
- Authors: Khatereh Aminoltejari
Abstract: The completion of the Human Genome Project in April of 2003, which culminated in the sequencing of the human genome, signaled the beginning of the “genome era.” Pharmacogenomics encompasses all genes in the genome that may determine drug response and is viewed as a highly important area for improving drug therapy in the future. In an interview, Dr. Stan Bardal, a faculty member with the UBC Medical Undergraduate Program, with an extensive knowledge in the field of pharmacology and pharmacogenomics provided insight into this burgeoning field of medicine.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Khatereh Aminoltejari
- A Guide for Navigating India for Future Global Health Teams
- Authors: Jesse Ory
Abstract: Each year, teams of medical students leave BC to take part in Global Health Initiative projects. I was in India with three other medical students this summer. We experienced several challenges while there, particularly during a 3-day "Train the Trainers" (TTT) workshop where I taught first aid to NGO volunteers. The difficulties I overcame during the first aid course reflected the challenges to be faces by any Western team traveling to India. Hopefully my experiences can help prepare future GHI teams traveling to similar areas. It should be noted that though the following stories are told from my perspective, the work done was collaborative in nature.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Jesse Ory
- Why med students should be heated up about climate change
- Authors: Michael A Benusic
Abstract: Future climate change is predicted to have a devastating effect on human health, with attributable morbidity and mortality already occurring. Climate-sensitive diseases such as malnutrition, diarrhea, vector-borne illnesses, and cardiovascular and respiratory disease are projected to increase, mainly in populations with an already high disease burden. Ironically, those who are most vulnerable are those who contribute the least to global greenhouse gas emissions. As health care professionals we can serve a role in national and international climate change policy, reduce emissions by advocating lifestyle choices that co-benefit health, and adapt health systems at home and abroad to increase resilience against future changes.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Michael A Benusic
- Non-invasive prenatal diagnosis - a new era
- Authors: Shifana Lalani|William Lau
Abstract: Recent advancements in genetics have changed the field of non-invasive prenatal diagnosis (NIPD). From the 1990’s, cell-free fetal DNA (cffDNA) has been detected in maternal plasma. Since then researchers have tried to enhance detection and quantification techniques in order to utilize this DNA in early prenatal diagnosis. As technology advances, there are a number of concerns requiring discussion – including ethical considerations of non-invasive prenatal testing, commercial utilization, and implementation into prenatal screening protocols. This commentary hopes to introduce cffDNA, the techniques used for detection, and ethical considerations for the future.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Shifana Lalani|William Lau
- Evidence Based Clinical Diagnosis: A Multimedia Summer Project
- Authors: Justine Spencer|Brian Buchan|Sarah Campos|Andrew Jeffery|Katelyn Sorenson
Abstract: Five Island Medical Program students from across three years collaborated with local physicians on a UBC Summer Student Internship Project about evidence based clinical diagnosis. We investigated this topic and created short educational clinical skills videos. The videos use the examples of appendicitis and congestive heart failure to explain how using a rational clinical exam is an effective way to rule in or out a diagnosis. Our experiences led us to reflect on the current clinical diagnosis teaching in contemporary medical education. It is our opinion that this important area is on the verge of becoming mainstream in medical education.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Justine Spencer|Brian Buchan|Sarah Campos|Andrew Jeffery|Katelyn Sorenson
- HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN ADULTS: TWO INSTRUCTIVE CASES
- Authors: Christopher Cheung
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is rare in adults. Two exemplary cases are presented here illustrating the clinical features, treatment and natural history of this aggressive and often fatal disease. A 21 year old man presented with jaundice and fever and was found to have CMV-triggered HLH. He responded well to the HLH-2004 protocol and remains in remission. A 45 year old woman presented with erythroderma and multi-organ failure and was found to have HLH associated with an abnormal T-cell population and low-titre EBV. She died despite etoposide-based therapy. HLH should be considered in patients with persistent unexplained inflammation, cytopenias, hepatitis, and coagulopathy. Serum ferritin is a useful screening test and hyperferritinemia > 10 000 μg/L is thought to be specific for hemophagocytosis. Tissue biopsy (bone marrow, lymph node or liver) to confirm hemophagocytosis is desirable, but is often a late finding and is not necessary for the diagnosis of HLH. Once the diagnosis is confirmed, rapid initiation of chemo-immunotherapy is required to induce remission.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Christopher Cheung
- Fever of Unknown Origin: a clinical approach
- Authors: Fergus To
Abstract: Fever of unknown origin remains a common challenge in clinical practice. A systematic approach to working up a patient includes a thorough history and physical exam. The most likely cause can then be assigned to one of four broad categories: infection, inflammatory, malignancy, and miscellaneous. These broader classes help guide initial diagnostic tests and avoid unnecessary, more invasive procedures. Despite a thorough workup, as many as 30% of all FUO cases are never solved. The current evidence points to a favourable prognosis for these cases and, thus, empiric treatment is generally not recommended. This review aims to help future physicians understand the broad differential diagnosis of FUO pathogenesis of diabetic retinopathy and neuropathy, and provides a summary of the current literature and evidence–based recommendations for working up FUO.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Fergus To
- The UBC Medical Curriculum and The Genomic Revolution
- Authors: J Friedman
Abstract: JF
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: J Friedman
- Clinical Genomics Today
- Authors: Connor Martin Forbes|Erica Tsang
Abstract: 1
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Connor Martin Forbes|Erica Tsang
- Integrating Genomics into Clinical Practice
- Authors: Linlea Armstrong
Abstract: 1
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Linlea Armstrong
- Barriers to safer injection practices faced by people who use intravenous drugs, in Vancouver and Abbotsford, B.C.
- Authors: Shannon Grant
Abstract: Abstract Objective Obstacles are often put in place to discourage users of injection drugs from using public facilities to inject. These include frequent security patrols, locked washroom facilities, and the installation of blue lights designed to obstruct the visualization of veins. Unfortunately, some of these interventions may have the unintended consequence of increasing the risks inherent to injecting drugs. We discuss a number of these barriers and argue that these barriers should be addressed to mitigate these risk factors. Methods We interviewed 18 individuals who were previous or current users of injection drugs with the goal of discussing the placement of blue lights in public washrooms and the impact this may have on limiting their ability to safely inject.
Results Interviewees informed us of numerous factors that were involved in selecting a location to inject. These factors influenced their comfort level and, consequently, influenced the speed and ease with which they would inject. Factors that negatively influenced comfort tended to increase the likelihood of missing veins and requiring multiple tries. These factors included: person related factors, such as the presence of authority figures or uninvolved members of the public; environmental factors, such as the level of light and temperature; and personal issues such as the depth, size or condition of veins. Conclusions While harm reduction education and the discussion of intentional barriers to the safe use of injection drugs are certainly beneficial, there are numerous physical and societal obstacles that prevent users of injection drugs from using their preferred, often safer methods.
PubDate: 2013-02-19
Issue No: Vol. 4 (2013)
- Authors: Shannon Grant



