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Journal Cover Cell
  [SJR: 28.188]   [H-I: 616]   [937 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
   Published by Elsevier Homepage  [3177 journals]
  • The Neurogenesis of Thought
    • Authors: Sarah Geisler
      First page: 1059
      Abstract: “I think, therefore I am,” a famous dictum attributed to the 17th century philosopher René Descartes, is deceptively simple, yet the biology at the heart of it is so overwhelmingly complex that it boggles the mind. Cognitive thought is a fundamental aspect of human existence, and the neural underpinnings of this fascinating ability have captivated inquisitive minds for centuries. In this exciting age of modern neuroscience, great progress is being made in understanding the neurobiology of thought from cellular, molecular, developmental, evolutionary, and systems neuroscience perspectives.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.05.001
      Issue No: Vol. 173, No. 5 (2018)
       
  • Challenging Stem Cells
    • Pages: 1063 - 1065
      Abstract: Over the last years the stem cell field has matured. We now have a basic understanding of how somatic cells are reprogrammed and can define the epigenetic state of pluripotent cells (PSCs). However, in my opinion, two major issues need to be addressed before the full power of the iPSC system for investigating human diseases can be realized: differentiation of PSCs into mature functional cells and their use in modeling with a disease-relevant readout.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.05.010
      Issue No: Vol. 173, No. 5 (2018)
       
  • Neurons Are the Inflammatory Problem
    • Authors: Kevin J. Tracey
      Pages: 1066 - 1068
      Abstract: The discovery that reflex neuronal circuits control immunity provided a new mechanistic understanding of infection and injury. Pinho-Ribeiro et al. (2018) report that lethal tissue destruction from streptococcal necrotizing fasciitis (“flesh-eating disease”) occurs because sensory neurons reflexively inhibit frontline immune responses.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.05.005
      Issue No: Vol. 173, No. 5 (2018)
       
  • Better Together: A Hybrid Amyloid Signals Necroptosis
    • Authors: Dan Li; Cong Liu
      Pages: 1068 - 1070
      Abstract: A new solid-state NMR study determines the high-resolution hetero-amyloid structure of the RIPK1-RIPK3 signaling complex that is involved in mediating necroptosis. The structure demonstrates specific formation of hetero-amyloids over homo-amyloids and the structural basis for a functional amyloid to act as a platform to recruit and activate downstream partners in intracellular signaling.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.030
      Issue No: Vol. 173, No. 5 (2018)
       
  • Social Isolation Co-opts Fear and Aggression Circuits
    • Authors: Jose Rodriguez-Romaguera; Garret D. Stuber
      Pages: 1071 - 1072
      Abstract: Social isolation is a stressful condition that often leads to maladaptive behaviors. In this issue of Cell, Zelikowsky et al. find that chronic social isolation stress triggers an increase in neuronal tachykinin signaling across distinct brain regions that mediate fear and aggression, elucidating the neural basis of these maladaptive responses.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.031
      Issue No: Vol. 173, No. 5 (2018)
       
  • Disease-Associated Microglia: A Universal Immune Sensor of
           Neurodegeneration
    • Authors: Aleksandra Deczkowska; Hadas Keren-Shaul, Assaf Weiner, Marco Colonna, Michal Schwartz, Ido Amit
      Pages: 1073 - 1081
      Abstract: Recent analyses of CNS immune cells in neurodegenerative conditions have identified a subset of microglia showing a unique transcriptional and functional signature, disease-associated microglia (DAM). This perspective proposes a role for DAM as a sensor of early CNS damage and discusses the therapeutic potential of modulating DAM function in CNS diseases.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.05.003
      Issue No: Vol. 173, No. 5 (2018)
       
  • Dietary and Microbial Oxazoles Induce Intestinal Inflammation by
           Modulating Aryl Hydrocarbon Receptor Responses
    • Authors: Shankar S. Iyer; Thomas Gensollen, Amit Gandhi, Sungwhan F. Oh, Joana F. Neves, Frederic Collin, Richard Lavin, Carme Serra, Jonathan Glickman, Punyanganie S.A. de Silva, R. Balfour Sartor, Gurdyal Besra, Russell Hauser, Anthony Maxwell, Amadeu Llebaria, Richard S. Blumberg
      Pages: 1123 - 1134.e11
      Abstract: A class of microbial and environmental compounds triggers inflammation in gut epithelial cells through the action of natural killer T cells and aryl hydrocarbon receptor signaling.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.037
      Issue No: Vol. 173, No. 5 (2018)
       
  • Structure of Telomerase with Telomeric DNA
    • Authors: Jiansen Jiang; Yaqiang Wang, Lukas Sušac, Henry Chan, Ritwika Basu, Z. Hong Zhou, Juli Feigon
      Pages: 1179 - 1190.e13
      Abstract: The cryo-EM structure of active Tetrahymena telomerase bound to telomeric DNA reveals unique insights into the catalytic core and DNA handling.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.038
      Issue No: Vol. 173, No. 5 (2018)
       
  • Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis
           Effectors BAX, BAK, and BOK
    • Authors: Francine F.S. Ke; Hannah K. Vanyai, Angus D. Cowan, Alex R.D. Delbridge, Lachlan Whitehead, Stephanie Grabow, Peter E. Czabotar, Anne K. Voss, Andreas Strasser
      Pages: 1217 - 1230.e17
      Abstract: Although apoptosis has been observed in many organs and tissues during embryonic development, it is not strictly required for the development of most organs.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.036
      Issue No: Vol. 173, No. 5 (2018)
       
  • The Neuropeptide Tac2 Controls a Distributed Brain State Induced by
           Chronic Social Isolation Stress
    • Authors: Moriel Zelikowsky; May Hui, Tomomi Karigo, Andrea Choe, Bin Yang, Mario R. Blanco, Keith Beadle, Viviana Gradinaru, Benjamin E. Deverman, David J. Anderson
      Pages: 1265 - 1279.e19
      Abstract: The Tac2 neuropeptide system orchestrates the complex behavioral effects of chronic social isolation stress by acting locally in multiple brain regions, suggesting the therapeutic potential of Nk3R antagonists for managing behavioral changes upon prolonged social isolation.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.03.037
      Issue No: Vol. 173, No. 5 (2018)
       
  • Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology
    • Authors: J. Alexander Bae; Shang Mu, Jinseop S. Kim, Nicholas L. Turner, Ignacio Tartavull, Nico Kemnitz, Chris S. Jordan, Alex D. Norton, William M. Silversmith, Rachel Prentki, Marissa Sorek, Celia David, Devon L. Jones, Doug Bland, Amy L.R. Sterling, Jungman Park, Kevin L. Briggman, H. Sebastian Seung, the Eyewirers
      Pages: 1293 - 1306.e19
      Abstract: A digital “museum” of retinal ganglion cells combines dense maps of anatomy and physiology at cellular resolution. The inner plexiform layer of the retina divides into four sublaminae defined by a purely anatomical principle of arbor segregation. We test the hypothesis that the aggregate neurite density of a ganglion cell type should be approximately uniform (“density conservation”). Ganglion cells arborizing in the inner marginal sublamina of the inner plexiform layer exhibit significantly more sustained visual responses on average.
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.040
      Issue No: Vol. 173, No. 5 (2018)
       
  • Mapping the Mouse Cell Atlas by Microwell-Seq
    • Authors: Xiaoping Han; Renying Wang, Yincong Zhou, Lijiang Fei, Huiyu Sun, Shujing Lai, Assieh Saadatpour, Ziming Zhou, Haide Chen, Fang Ye, Daosheng Huang, Yang Xu, Wentao Huang, Mengmeng Jiang, Xinyi Jiang, Jie Mao, Yao Chen, Chenyu Lu, Jin Xie, Qun Fang, Yibin Wang, Rui Yue, Tiefeng Li, He Huang, Stuart H. Orkin, Guo-Cheng Yuan, Ming Chen, Guoji Guo
      First page: 1307
      Abstract: (Cell 172, 1091–1107; February 22, 2018)
      Citation: Cell 173, 5 (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.05.012
      Issue No: Vol. 173, No. 5 (2018)
       
  • Disease Heritability Inferred from Familial Relationships Reported in
           Medical Records
    • Authors: Fernanda C.G. Polubriaginof; Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark M. Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, Nicholas P. Tatonetti
      Abstract: Electronic health records can be mined for familial relationships that provide distinct insights into heritability of human disease.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.032
       
  • The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
           C-Terminal Degrons
    • Authors: Itay Koren; Richard T. Timms, Tomasz Kula, Qikai Xu, Mamie Z. Li, Stephen J. Elledge
      Abstract: C-terminal degron motifs regulate mammalian protein stability via interactions with Cullin-RING E3 ubiquitin ligase complexes.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.028
       
  • The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection
    • Authors: Jeffrey E. Markowitz; Winthrop F. Gillis, Celia C. Beron, Shay Q. Neufeld, Keiramarie Robertson, Neha D. Bhagat, Ralph E. Peterson, Emalee Peterson, Minsuk Hyun, Scott W. Linderman, Bernardo L. Sabatini, Sandeep Robert Datta
      Abstract: The striatum concatenates sub-second 3D behavioral motifs into action sequences during naturalistic behaviors.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.019
       
  • Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide
           Mechanisms that Control Transcription Factor Binding and Function
    • Authors: Verena M. Link; Sascha H. Duttke, Hyun B. Chun, Inge R. Holtman, Emma Westin, Marten A. Hoeksema, Yohei Abe, Dylan Skola, Casey E. Romanoski, Jenhan Tao, Gregory J. Fonseca, Ty D. Troutman, Nathanael J. Spann, Tobias Strid, Mashito Sakai, Miao Yu, Rong Hu, Rongxin Fang, Dirk Metzler, Bing Ren, Christopher K. Glass
      Abstract: Analyses of genetic variation in macrophages from inbred mouse strains reveal how a complex network of transcription factors influence cis-regulatory elements to impact differentiation and responses to environmental change.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.018
       
  • PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A)
           RNAs
    • Authors: Xing Liu; Rui Fu, Youdong Pan, Karla F. Meza-Sosa, Zhibin Zhang, Judy Lieberman
      Abstract: Widespread RNA decay during apoptosis is initiated by the mitochondrial exoribonuclease PNPT1.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.017
       
  • Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel
           Glutamate Biosynthetic Pathway in the Brain
    • Authors: Hongying Zhu; Ning Wang, Lei Yao, Qi Chen, Ran Zhang, Junchao Qian, Yiwen Hou, Weiwei Guo, Sijia Fan, Siling Liu, Qiaoyun Zhao, Feng Du, Xin Zuo, Yujun Guo, Yan Xu, Jiali Li, Tian Xue, Kai Zhong, Xiaoyuan Song, Guangming Huang, Wei Xiong
      Abstract: UV-induced upregulation of a small molecule feeds into an intraneuronal metabolic pathway for glutamate biosynthesis that can enhance learning and memory.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.014
       
  • Intermittent Pili-Mediated Forces Fluidize Neisseria meningitidis
           Aggregates Promoting Vascular Colonization
    • Authors: Daria Bonazzi; Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
      Abstract: Meningitis-causing bacteria form viscous fluid aggregates in blood vessels with high bacterial diffusion that enhance infection.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.010
       
  • The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as
           well as Topological Mechanisms
    • Authors: Madhusudhan Srinivasan; Johanna C. Scheinost, Naomi J. Petela, Thomas G. Gligoris, Maria Wissler, Sugako Ogushi, James E. Collier, Menelaos Voulgaris, Alexander Kurze, Kok-Lung Chan, Bin Hu, Vincenzo Costanzo, Kim A. Nasmyth
      Abstract: Cohesin can selectively engage DNA without entrapping it, suggesting a new dimension to cohesin function.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.015
       
  • An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic
           Potential
    • Authors: Liqin Wang; Rodrigo Leite de Oliveira, Sanne Huijberts, Evert Bosdriesz, Nora Pencheva, Diede Brunen, Astrid Bosma, Ji-Ying Song, John Zevenhoven, G. Tjitske Los-de Vries, Hugo Horlings, Bastiaan Nuijen, Jos H. Beijnen, Jan H.M. Schellens, Rene Bernards
      Abstract: Collateral sensitivity in BRAF inhibitor-resistant melanoma may confer selective vulnerability to histone deacetylase inhibitors.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.012
       
  • A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate
           Stabilization
    • Authors: Maike M.K. Hansen; Winnie Y. Wen, Elena Ingerman, Brandon S. Razooky, Cassandra E. Thompson, Roy D. Dar, Charles W. Chin, Michael L. Simpson, Leor S. Weinberger
      Abstract: Noise helps drive fate decisions, and a mechanism rooted in alternative splicing allows cells to stop dithering and commit.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.005
       
  • Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer
    • Authors: Allen W. Zhang; Andrew McPherson, Katy Milne, David R. Kroeger, Phineas T. Hamilton, Alex Miranda, Tyler Funnell, Nicole Little, Camila P.E. de Souza, Sonya Laan, Stacey LeDoux, Dawn R. Cochrane, Jamie L.P. Lim, Winnie Yang, Andrew Roth, Maia A. Smith, Julie Ho, Kane Tse, Thomas Zeng, Inna Shlafman, Michael R. Mayo, Richard Moore, Henrik Failmezger, Andreas Heindl, Yi Kan Wang, Ali Bashashati, Diljot S. Grewal, Scott D. Brown, Daniel Lai, Adrian N.C. Wan, Cydney B. Nielsen, Curtis Huebner, Basile Tessier-Cloutier, Michael S. Anglesio, Alexandre Bouchard-Côté, Yinyin Yuan, Wyeth W. Wasserman, C. Blake Gilks, Anthony N. Karnezis, Samuel Aparicio, Jessica N. McAlpine, David G. Huntsman, Robert A. Holt, Brad H. Nelson, Sohrab P. Shah
      Abstract: Integrated multi-region analysis of metastatic sites in patients with high-grade ovarian cancer highlights the connection between immune microenvironment variation and malignant spread, as well as the combinatorial prognostic value of immune and mutational features.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.073
       
  • Structure of an Ancient Respiratory System
    • Authors: Hongjun Yu; Chang-Hao Wu, Gerrit J. Schut, Dominik K. Haja, Gongpu Zhao, John W. Peters, Michael W.W. Adams, Huilin Li
      Abstract: The structure of a respiratory complex from a hyperthermophilic archaeon offers insights into the evolution of mitochondrial complex I
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.071
       
  • LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live
           Embryos
    • Authors: Jacques P. Bothma; Matthew R. Norstad, Simon Alamos, Hernan G. Garcia
      Abstract: A fluorescent protein tagging strategy reveals a role for inter-nuclear signaling and coordination of protein levels between neighboring nuclei in Drosophila embryogenesis.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.069
       
  • Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex
           at Sites of Meiotic Recombination
    • Authors: Alexander Woglar; Anne M. Villeneuve
      Abstract: Structured-illumination microscopy of meiotic chromosomes reveals that distinct architecture and spatial compartmentalization are associated with differential timing and outcome of repair at crossover and non-crossover sites.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.066
       
  • Corticoamygdala Transfer of Socially Derived Information Gates
           Observational Learning
    • Authors: Stephen A. Allsop; Romy Wichmann, Fergil Mills, Anthony Burgos-Robles, Chia-Jung Chang, Ada C. Felix-Ortiz, Alienor Vienne, Anna Beyeler, Ehsan M. Izadmehr, Gordon Glober, Meghan I. Cum, Johanna Stergiadou, Kavitha K. Anandalingam, Kathryn Farris, Praneeth Namburi, Christopher A. Leppla, Javier C. Weddington, Edward H. Nieh, Anne C. Smith, Demba Ba, Emery N. Brown, Kay M. Tye
      Abstract: For an individual to watch another’s experience and learn from it, signals need to move from cortical neurons to the basolateral amygdala during detection and integration of the necessary social cues.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.04.004
       
  • Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
    • Authors: Seung Woo Cho; Jin Xu, Ruping Sun, Maxwell R. Mumbach, Ava C. Carter, Y. Grace Chen, Kathryn E. Yost, Jeewon Kim, Jing He, Stephanie A. Nevins, Suet-Feung Chin, Carlos Caldas, S. John Liu, Max A. Horlbeck, Daniel A. Lim, Jonathan S. Weissman, Christina Curtis, Howard Y. Chang
      Abstract: Recurrent mutations in human cancer are found encompassing the promotor for the lncRNA gene PVT1, which regulates MYC transcription via promoter competition for a shared set of enhancers.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.03.068
       
  • Identification of Near-Pan-neutralizing Antibodies against HIV-1 by
           Deconvolution of Plasma Humoral Responses
    • Authors: Mohammad Mohseni Sajadi; Amir Dashti, Zahra Rikhtegaran Tehrani, William D. Tolbert, Michael S. Seaman, Xin Ouyang, Neelakshi Gohain, Marzena Pazgier, Dongkyoon Kim, Guy Cavet, Jean Yared, Robert R. Redfield, George K. Lewis, Anthony L. DeVico
      Abstract: An HIV-neutralizing antibody achieves near-pan-neutralizing activity through recognition of a highly conserved, difficult-to-access region of the viral gp120 glycoprotein.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.03.061
       
  • A Lignin Molecular Brace Controls Precision Processing of Cell Walls
           Critical for Surface Integrity in Arabidopsis
    • Authors: Yuree Lee; Taek Han Yoon, Jiyoun Lee, So Yeon Jeon, Jae Ho Lee, Mi Kyoung Lee, Huize Chen, Ju Yun, Se Yun Oh, Xiaohong Wen, Hui Kyung Cho, Hyunggon Mang, June M. Kwak
      Abstract: A honeycomb-shaped structure of lignin is a key feature, allowing the precise separation between two cell layers during flower abscission.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.03.060
       
  • Single-Cell Chromatin Modification Profiling Reveals Increased Epigenetic
           Variations with Aging
    • Authors: Peggie Cheung; Francesco Vallania, Hayley C. Warsinske, Michele Donato, Steven Schaffert, Sarah E. Chang, Mai Dvorak, Cornelia L. Dekker, Mark M. Davis, Paul J. Utz, Purvesh Khatri, Alex J. Kuo
      Abstract: A global look at human chromatin shows that variability in histone modification patterns accrues with age and depends on non-heritable factors.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.079
       
  • Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape
           of Human Hematopoietic Differentiation
    • Authors: Jason D. Buenrostro; M. Ryan Corces, Caleb A. Lareau, Beijing Wu, Alicia N. Schep, Martin J. Aryee, Ravindra Majeti, Howard Y. Chang, William J. Greenleaf
      Abstract: Integrative analysis of single-cell transcriptomics and chromatin accessibility provides insights into regulatory features and dynamics in human hematopoiesis.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.074
       
  • Modulation of Protein-Interaction States through the Cell Cycle
    • Authors: Lingyun Dai; Tianyun Zhao, Xavier Bisteau, Wendi Sun, Nayana Prabhu, Yan Ting Lim, Radoslaw M. Sobota, Philipp Kaldis, Pär Nordlund
      Abstract: Using a proteomic method based on thermal stability, the interaction states for more than 750 proteins are observed to change at cell-cycle transitions.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.065
       
  • Pervasive Protein Thermal Stability Variation during the Cell Cycle
    • Authors: Isabelle Becher; Amparo Andrés-Pons, Natalie Romanov, Frank Stein, Maike Schramm, Florence Baudin, Dominic Helm, Nils Kurzawa, André Mateus, Marie-Therese Mackmull, Athanasios Typas, Christoph W. Müller, Peer Bork, Martin Beck, Mikhail M. Savitski
      Abstract: A proteome-wide assessment of thermal stability and solubility during the eukaryotic cell cycle demonstrates pervasive variation in mitosis and G1.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.053
       
  • Universal Chimeric Antigen Receptors for Multiplexed and Logical Control
           of T Cell Responses
    • Authors: Jang Hwan Cho; James J. Collins, Wilson W. Wong
      Abstract: A chimeric antigen receptor system that can integrate signals from multiple antigens and fine-tune T cell activation in a cell-type-specific manner holds promise for enhancing the safety and specificity of CAR T cell therapies for cancer treatment.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.038
       
  • Opposite Roles of Salicylic Acid Receptors NPR1 and NPR3/NPR4 in
           Transcriptional Regulation of Plant Immunity
    • Authors: Yuli Ding; Tongjun Sun, Kevin Ao, Yujun Peng, Yaxi Zhang, Xin Li, Yuelin Zhang
      Abstract: Salicylic acid receptors NPR1 and NPR3/NPR4 play opposite roles in the transcriptional regulation of plant defense against pathogens.
      Citation: Cell (2018)
      PubDate: 2018-04-12
      DOI: 10.1016/j.cell.2018.03.044
       
  • Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive
           Infection
    • Authors: Felipe A. Pinho-Ribeiro; Buket Baddal, Rianne Haarsma, Maghnus O’Seaghdha, Nicole J. Yang, Kimbria J. Blake, Makayla Portley, Waldiceu A. Verri, James B. Dale, Michael R. Wessels, Isaac M. Chiu
      First page: 1083
      Abstract: Flesh-eating bacteria hijack a pain response that suppresses host defense, and blocking this neuro-immune communication holds potential for treatment.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.006
       
  • The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral
           Immunity
    • Authors: Stephanie S. Pavlovich; Sean P. Lovett, Galina Koroleva, Jonathan C. Guito, Catherine E. Arnold, Elyse R. Nagle, Kirsten Kulcsar, Albert Lee, Françoise Thibaud-Nissen, Adam J. Hume, Elke Mühlberger, Luke S. Uebelhoer, Jonathan S. Towner, Raul Rabadan, Mariano Sanchez-Lockhart, Thomas B. Kepler, Gustavo Palacios
      First page: 1098
      Abstract: The genome of the Egyptian fruit bat reveals how its immune defenses allow tolerance of pathogenic viruses.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.070
       
  • Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys
    • Authors: Amanda J. Martinot; Peter Abbink, Onur Afacan, Anna K. Prohl, Roderick Bronson, Jonathan L. Hecht, Erica N. Borducchi, Rafael A. Larocca, Rebecca L. Peterson, William Rinaldi, Melissa Ferguson, Peter J. Didier, Deborah Weiss, Mark G. Lewis, Rafael A. De La Barrera, Edward Yang, Simon K. Warfield, Dan H. Barouch
      First page: 1111
      Abstract: ZIKV infection in early pregnant female rhesus monkeys resulted in fetal neuropathology with vascular compromise and neuroprogenitor cell dysfunction, similar to congenital ZIKV syndrome in human infants.
      Citation: Cell (2018)
      PubDate: 2018-03-29
      DOI: 10.1016/j.cell.2018.03.019
       
  • Vitamin D Switches BAF Complexes to Protect β Cells
    • Authors: Zong Wei; Eiji Yoshihara, Nanhai He, Nasun Hah, Weiwei Fan, Antonio F.M. Pinto, Timothy Huddy, Yuhao Wang, Brittany Ross, Gabriela Estepa, Yang Dai, Ning Ding, Mara H. Sherman, Sungsoon Fang, Xuan Zhao, Christopher Liddle, Annette R. Atkins, Ruth T. Yu, Michael Downes, Ronald M. Evans
      First page: 1135
      Abstract: Modulation of a ligand-dependent switch between VDR-associated chromatin remodeling complexes enhances vitamin D response in β cells and curbs T2D progression.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.013
       
  • Co-optation of Tandem DNA Repeats for the Maintenance of Mesenchymal
           Identity
    • Authors: Chiara Balestrieri; Gabriele Alfarano, Marta Milan, Valentina Tosi, Elena Prosperini, Paola Nicoli, Andrea Palamidessi, Giorgio Scita, Giuseppe R. Diaferia, Gioacchino Natoli
      First page: 1150
      Abstract: Tandem repeats, iterated and unstable sequences generated by DNA replication errors, can be integrated into ancient gene regulatory networks controlling mesenchymal identity and stabilized in the human genome.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.081
       
  • The Energetics and Physiological Impact of Cohesin Extrusion
    • Authors: Laura Vian; Aleksandra Pękowska, Suhas S.P. Rao, Kyong-Rim Kieffer-Kwon, Seolkyoung Jung, Laura Baranello, Su-Chen Huang, Laila El Khattabi, Marei Dose, Nathanael Pruett, Adrian L. Sanborn, Andres Canela, Yaakov Maman, Anna Oksanen, Wolfgang Resch, Xingwang Li, Byoungkoo Lee, Alexander L. Kovalchuk, Zhonghui Tang, Steevenson Nelson, Michele Di Pierro, Ryan R. Cheng, Ido Machol, Brian Glenn St Hilaire, Neva C. Durand, Muhammad S. Shamim, Elena K. Stamenova, José N. Onuchic, Yijun Ruan, Andre Nussenzweig, David Levens, Erez Lieberman Aiden, Rafael Casellas
      First page: 1165
      Abstract: Cohesin continually extrudes loops of chromatin in vivo, relying on ATP to fuel the process.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.072
       
  • Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA
           Substrate
    • Authors: Zhongmin Liu; Jia Wang, Hang Cheng, Xin Ke, Lei Sun, Qiangfeng Cliff Zhang, Hong-Wei Wang
      First page: 1191
      Abstract: Structural analysis of human Dicer shows how it collaborates with an accessory protein to position a pre-miRNA substrate for processing.
      Citation: Cell (2018)
      PubDate: 2018-04-26
      DOI: 10.1016/j.cell.2018.03.080
       
  • Pseudouridylation of tRNA-Derived Fragments Steers Translational Control
           in Stem Cells
    • Authors: Nicola Guzzi; Maciej Cieśla, Phuong Cao Thi Ngoc, Stefan Lang, Sonali Arora, Marios Dimitriou, Kristyna Pimková, Mikael N.E. Sommarin, Roberto Munita, Michal Lubas, Yiting Lim, Kazuki Okuyama, Shamit Soneji, Göran Karlsson, Jenny Hansson, Göran Jönsson, Anders H. Lund, Mikael Sigvardsson, Eva Hellström-Lindberg, Andrew C. Hsieh, Cristian Bellodi
      First page: 1204
      Abstract: Translational control in stem cells is orchestrated by pseudouridylation of specific tRNA-derived fragments, impacting stem cell commitment during key developmental processes.
      Citation: Cell (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.cell.2018.03.008
       
  • Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE
    • Authors: Yong Wang; Miao Shi, Han Feng, Yalan Zhu, Songqing Liu, Ang Gao, Pu Gao
      First page: 1231
      Abstract: Structural and biochemical data provide insights into the two-step mechanism by which the SidE family of effector proteins ubiquitinate several human proteins without engaging the canonical ubiquitin machinery.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.04.023
       
  • The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid
           Signaling Complex
    • Authors: Miguel Mompeán; Wenbo Li, Jixi Li, Ségolène Laage, Ansgar B. Siemer, Gunes Bozkurt, Hao Wu, Ann E. McDermott
      First page: 1244
      Abstract: Solid-state NMR structures of the human necroptosis RIPK1-RIPK3 complex reveal a hetero-oligomeric amyloid signaling complex.
      Citation: Cell (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.cell.2018.03.032
       
  • Disease-Causing Mutations in the G Protein Gαs Subvert the Roles of
           GDP and GTP
    • Authors: Qi Hu; Kevan M. Shokat
      First page: 1254
      Abstract: Frequent pathogenic mutations in G proteins can cause signaling activation by converting GDP into an activator, rather than locking the proteins at a GTP-bound state.
      Citation: Cell (2018)
      PubDate: 2018-04-05
      DOI: 10.1016/j.cell.2018.03.018
       
  • Dissociable Structural and Functional Hippocampal Outputs via Distinct
           Subiculum Cell Classes
    • Authors: Mark S. Cembrowski; Matthew G. Phillips, Salvatore F. DiLisio, Brenda C. Shields, Johan Winnubst, Jayaram Chandrashekar, Erhan Bas, Nelson Spruston
      First page: 1280
      Abstract: Within the serially connected subfields of the hippocampus, specific elements of memory are processed via functionally distinct pathways in the subiculum.
      Citation: Cell (2018)
      PubDate: 2018-04-19
      DOI: 10.1016/j.cell.2018.03.031
       
 
 
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