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Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1221  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3177 journals]
  • Walter Fiers (1931–2019)
    • Authors: Wim Declercq; Peter Vandenabeele, Xavier Saelens
      Pages: 1241 - 1243
      Abstract: Walter Fiers, professor in Molecular Biology, passed away on July 28, 2019. From the very beginning of his scientific career, Walter Fiers has made groundbreaking contributions in a vast number of domains ranging from pure molecular biology to molecular virology to molecular immunology and biotechnology. His work revealed the existence of circular genetic elements, helped to resolve the universal genetic code, included the first-ever deciphered full-genome sequence, and contributed to the discovery of mRNA splicing in eukaryotes.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      Issue No: Vol. 179, No. 6 (2019)
       
  • Escherichia coli in Auto(trophic) Mode
    • Authors: Tobias J. Erb; Philipp Keller, Julia A. Vorholt
      Pages: 1244 - 1245
      Abstract: It is challenging to convert a heterotrophic organism that loves sugars and other multicarbon compounds as energy and carbon sources into an autotroph that builds all biomass from carbon dioxide. In this issue, Gleizer et al. demonstrate how this can be achieved.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      Issue No: Vol. 179, No. 6 (2019)
       
  • Saved by the Matrix: UPR Independent Survival under ER Stress
    • Authors: Mandy Koopman; Claudio Hetz, Ellen A.A. Nollen
      Pages: 1246 - 1248
      Abstract: Cells are protected from endoplasmic reticulum stress through the unfolded protein response (UPR). In this issue of Cell, Schinzel, Higuchi-Sanabria, Shalem et al., identify a mechanism that helps cells cope with ER stress but is independent of canonical UPR activation, instead involving the extracellular matrix hyaluronidase, TMEM2, as a signaling mediator.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      DOI: 10.1016/j.cell.2019.11.012
      Issue No: Vol. 179, No. 6 (2019)
       
  • RNA-Binding Proteins Chaperone Ribonucleoprotein Complex Assembly to Solve
           the RNA-Folding Problem
    • Authors: Katherine E. Bohnsack; Markus T. Bohnsack
      Pages: 1248 - 1250
      Abstract: The inherent tendency of RNAs to misfold is a major problem that can impede efficient assembly of essential ribonucleoprotein complexes (RNPs), such as ribosomes. In this issue of Cell, Duss et al., (2019) and Rogers and Woodson (2019) reveal how transient RNA-protein interactions can chaperone RNA folding during RNP assembly.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      DOI: 10.1016/j.cell.2019.11.011
      Issue No: Vol. 179, No. 6 (2019)
       
  • Modeling the Evolution of Human Brain Development Using Organoids
    • Authors: Sydney Keaton Muchnik; Belen Lorente-Galdos, Gabriel Santpere, Nenad Sestan
      Pages: 1250 - 1253
      Abstract: In a recent issue of Nature, Kanton et al. explore human brain evolution and development by profiling the single-cell transcriptomes and epigenomes of cerebral organoids derived from human, chimpanzee, and macaque stem cells. Their results reveal key molecular characteristics that differentiate humans and non-human primates at the earliest stages of brain development.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      Issue No: Vol. 179, No. 6 (2019)
       
  • Conversion of Escherichia coli to Generate All Biomass Carbon from CO2
    • Authors: Shmuel Gleizer; Roee Ben-Nissan, Yinon M. Bar-On, Niv Antonovsky, Elad Noor, Yehudit Zohar, Ghil Jona, Eyal Krieger, Melina Shamshoum, Arren Bar-Even, Ron Milo
      Pages: 1255 - 1263.e12
      Abstract: Metabolic rewiring and directed evolution led to the emergence of E. coli clones that use CO2 as their sole carbon source, while formate is oxidized to provide all the reducing power and energy demands.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      DOI: 10.1016/j.cell.2019.11.009
      Issue No: Vol. 179, No. 6 (2019)
       
  • TLR8 Is a Sensor of RNase T2 Degradation Products
    • Authors: Wilhelm Greulich; Mirko Wagner, Moritz M. Gaidt, Che Stafford, Yiming Cheng, Andreas Linder, Thomas Carell, Veit Hornung
      Pages: 1264 - 1275.e13
      Abstract: Human TLR8 activation involves recognition of specific RNA products generated by the enzyme RNase T2.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      DOI: 10.1016/j.cell.2019.11.001
      Issue No: Vol. 179, No. 6 (2019)
       
  • GPR146 Deficiency Protects against Hypercholesterolemia and
           Atherosclerosis
    • Authors: Haojie Yu; Antoine Rimbert, Alice E. Palmer, Takafumi Toyohara, Yulei Xia, Fang Xia, Leonardo M.R. Ferreira, Zhifen Chen, Tao Chen, Natalia Loaiza, Nathaniel Brooks Horwitz, Michael C. Kacergis, Liping Zhao, BIOS Consortium, Alexander A. Soukas, Jan Albert Kuivenhoven, Sekar Kathiresan, Chad A. Cowan
      Pages: 1276 - 1288.e14
      Abstract: An orphan G protein-coupled receptor, GPR146, regulates plasma cholesterol levels via ERK signaling and targeting GPR146 in mice reduces both plasma cholesterol levels and atherosclerotic lesions independently of an intact LDL receptor.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      Issue No: Vol. 179, No. 6 (2019)
       
  • Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis
    • Authors: Keren I. Hilgendorf; Carl T. Johnson, Anja Mezger, Selena L. Rice, Alessandra M. Norris, Janos Demeter, William J. Greenleaf, Jeremy F. Reiter, Daniel Kopinke, Peter K. Jackson
      Pages: 1289 - 1305.e21
      Abstract: An omega-3 fatty acid drives adipogenesis through ciliary signaling.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      DOI: 10.1016/j.cell.2019.11.005
      Issue No: Vol. 179, No. 6 (2019)
       
  • The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity
           Independent of the UPRER
    • Authors: Robert Thomas Schinzel; Ryo Higuchi-Sanabria, Ophir Shalem, Erica Ann Moehle, Brant Michael Webster, Larry Joe, Raz Bar-Ziv, Phillip Andrew Frankino, Jenni Durieux, Corinne Pender, Naame Kelet, Saranya Santhosh Kumar, Nupur Savalia, Hannah Chi, Milos Simic, Ngoc-Tram Nguyen, Andrew Dillin
      Pages: 1306 - 1318.e18
      Abstract: Intracellular ER stress resistance is impacted by changes in extracellular matrix metabolism.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      Issue No: Vol. 179, No. 6 (2019)
       
  • Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
    • Authors: Kuang Shen; Kacper B. Rogala, Hui-Ting Chou, Rick K. Huang, Zhiheng Yu, David M. Sabatini
      Pages: 1319 - 1329.e8
      Abstract: Seeing how the FLCN-FNIP2 GTPase activating protein complex engages with Rag GTPases to modulate mTORC1 signaling suggests new ways to regulate GTPase function.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-05
      Issue No: Vol. 179, No. 6 (2019)
       
  • Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
    • Authors: Andrew R. Morton; Nergiz Dogan-Artun, Zachary J. Faber, Graham MacLeod, Cynthia F. Bartels, Megan S. Piazza, Kevin C. Allan, Stephen C. Mack, Xiuxing Wang, Ryan C. Gimple, Qiulian Wu, Brian P. Rubin, Shashirekha Shetty, Stephane Angers, Peter B. Dirks, Richard C. Sallari, Mathieu Lupien, Jeremy N. Rich, Peter C. Scacheri
      Pages: 1330 - 1341.e13
      Abstract: Extrachromosomal oncogene amplification is a common occurrence across a broad range of cancers, yet the chromatin landscape of these high-level amplifications is poorly understood. Using a combination of approaches to explore their chromatin topology and enhancer landscape, Morton et al. observed that these oncogene amplifications are shaped by regulatory dependencies in the non-coding genome.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      Issue No: Vol. 179, No. 6 (2019)
       
  • Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction
           Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
    • Authors: Alfredo M. Valencia; Clayton K. Collings, Hai T. Dao, Roodolph St. Pierre, Yung-Chih Cheng, Junwei Huang, Zhen-Yu Sun, Hyuk-Soo Seo, Nazar Mashtalir, Dawn E. Comstock, Olubusayo Bolonduro, Nicholas E. Vangos, Zoe C. Yeoh, Mary Kate Dornon, Crystal Hermawan, Lee Barrett, Sirano Dhe-Paganon, Clifford J. Woolf, Tom W. Muir, Cigall Kadoch
      Pages: 1342 - 1356.e23
      Abstract: The SMARCB1 C-terminal alpha-helical domain binds the nucleosome acidic patch and mediates mSWI/SNF chromatin remodeling.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-20
      Issue No: Vol. 179, No. 6 (2019)
       
  • Transient Protein-RNA Interactions Guide Nascent Ribosomal RNA Folding
    • Authors: Olivier Duss; Galina A. Stepanyuk, Joseph D. Puglisi, James R. Williamson
      Pages: 1357 - 1369.e16
      Abstract: Core ribosomal proteins act as chaperones, helping to shape the nascent RNA before becoming stably incorporated into the growing ribosomal particle.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      Issue No: Vol. 179, No. 6 (2019)
       
  • Transcription Increases the Cooperativity of Ribonucleoprotein Assembly
    • Authors: Margaret L. Rodgers; Sarah A. Woodson
      Pages: 1370 - 1381.e12
      Abstract: Concomitant single-molecule detection of transcription elongation and protein recruitment reveals dynamic sampling of nascent pre-ribosomal RNA by ribosomal proteins until multiple proteins can bind and commit the elongating pre-rRNA to productive assembly.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      DOI: 10.1016/j.cell.2019.11.007
      Issue No: Vol. 179, No. 6 (2019)
       
  • Continual Learning in a Multi-Layer Network of an Electric Fish
    • Authors: Salomon Z. Muller; Abigail N. Zadina, L.F. Abbott, Nathaniel B. Sawtell
      Pages: 1382 - 1392.e10
      Abstract: Using a cerebellum-like structure in an electric fish as a model system for investigating mechanisms of learning in multi-layer networks, Muller et al. observed that functional compartmentalization within individual neurons allows synaptic plasticity at an intermediate processing layer to adaptively shape network output.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-14
      Issue No: Vol. 179, No. 6 (2019)
       
  • Periodic Remodeling in a Neural Circuit Governs Timing of Female Sexual
           Behavior
    • Authors: Sayaka Inoue; Renzhi Yang, Adarsh Tantry, Chung-ha Davis, Taehong Yang, Joseph R. Knoedler, Yichao Wei, Eliza L. Adams, Shivani Thombare, Samantha R. Golf, Rachael L. Neve, Marc Tessier-Lavigne, Jun B. Ding, Nirao M. Shah
      Pages: 1393 - 1408.e16
      Abstract: Female mating behavior is coordinated with ovulation by estrogen-dependent anatomical and functional remodeling that increases the connections between key neurons in the hypothalamus of mice.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-14
      Issue No: Vol. 179, No. 6 (2019)
       
  • The Making of a Flight Feather: Bio-architectural Principles and
           Adaptation
    • Authors: Wei-Ling Chang; Hao Wu, Yu-Kun Chiu, Shuo Wang, Ting-Xin Jiang, Zhong-Lai Luo, Yen-Cheng Lin, Ang Li, Jui-Ting Hsu, Heng-Li Huang, How-Jen Gu, Tse-Yu Lin, Shun-Min Yang, Tsung-Tse Lee, Yung-Chi Lai, Mingxing Lei, Ming-You Shie, Cheng-Te Yao, Yi-Wen Chen, J.C. Tsai, Shyh-Jou Shieh, Yeu-Kuang Hwu, Hsu-Chen Cheng, Pin-Chi Tang, Shih-Chieh Hung, Chih-Feng Chen, Michael Habib, Randall B. Widelitz, Ping Wu, Wen-Tau Juan, Cheng-Ming Chuong
      Pages: 1409 - 1423.e17
      Abstract: The design and developmental paradigms of flight feathers are explored using a combination of bio-physical analyses, molecular characterization, and evolutionary comparisons across a broad range of birds with different flight modes, revealing a modular architectural design that can accommodate diverse eco-spaces.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-27
      DOI: 10.1016/j.cell.2019.11.008
      Issue No: Vol. 179, No. 6 (2019)
       
  • Screening Human Embryos for Polygenic Traits Has Limited Utility
    • Authors: Ehud Karavani; Or Zuk, Danny Zeevi, Nir Barzilai, Nikos C. Stefanis, Alex Hatzimanolis, Nikolaos Smyrnis, Dimitrios Avramopoulos, Leonid Kruglyak, Gil Atzmon, Max Lam, Todd Lencz, Shai Carmi
      Pages: 1424 - 1435.e8
      Abstract: Recent progress in genetic testing of embryos has made it technically feasible to profile IVF embryos for polygenic traits such as height or IQ, but simulations, models, and empirical data show that the gain in trait value when selecting the top-scoring embryo is currently limited and uncertain.
      Citation: Cell 179, 6 (2019)
      PubDate: 2019-11-21
      Issue No: Vol. 179, No. 6 (2019)
       
 
 
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