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Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1281  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3204 journals]
  • Reducing Treatment Burden in AMD
    • Authors: Rajendra S. Apte
      First page: 1033
      Abstract: VEGF-A antagonists have revolutionized wet AMD treatment. Several challenges remain including high treatment burden requiring repeated intraocular injections for persistent disease. Brolucizumab directly inhibits VEGF-A function, providing visual outcomes comparable to aflibercept (an FDA-approved VEGF-A antagonist). Anatomic retinal outcomes including retinal fluid, a marker of disease activity, favored brolucizumab. To view this Bench to Bedisde, open or download the PDF.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.028
      Issue No: Vol. 180, No. 6 (2020)
       
  • The Novel Coronavirus Outbreak: What We Know and What We Don’t
    • Pages: 1034 - 1036
      Abstract: A severe respiratory disease emerged in the city of Wuhan, Hubei province, China, in December 2019. As of early February 2020, at least 28,088 diagnosed and 24,702 suspected cases have been reported, including at least 564 deaths. Unfortunately, the disease has spread globally. The etiologic agent, a novel coronavirus, now called SARS-CoV-2, was immediately identified and characterized in China. Although we know the presence of unprecedented genetic diversity of viruses in nature, this outbreak further indicates that there is considerable uncertainty in predicting when, where, and how novel disease-causing pathogens emerge.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-02-19
      DOI: 10.1016/j.cell.2020.02.027
      Issue No: Vol. 180, No. 6 (2020)
       
  • Chemotherapy Induces Cancer-Fighting B Cells
    • Authors: Zhida Liu; Yang-Xin Fu
      Pages: 1037 - 1039
      Abstract: Tumor-infiltrating B cells are heterogeneous, and their roles in tumor immunity are controversial. In this issue of Cell, Lu and colleagues demonstrate that chemotherapy-induced complement signals promote the generation of ICOSL+B cells, which enhance tumor-specific T cell responses.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-05
      DOI: 10.1016/j.cell.2020.02.046
      Issue No: Vol. 180, No. 6 (2020)
       
  • Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II
           Ubiquitylation
    • Authors: Kook Son; Orlando D. Schärer
      Pages: 1039 - 1041
      Abstract: Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.053
      Issue No: Vol. 180, No. 6 (2020)
       
  • Terminating G-Protein Coupling: Structural Snapshots of
           GPCR-β-Arrestin Complexes
    • Authors: Madhu Chaturvedi; Jagannath Maharana, Arun K. Shukla
      Pages: 1041 - 1043
      Abstract: β-arrestins (βarrs) play multifaceted roles in the signaling and regulation of G-protein-coupled receptors (GPCRs) including their desensitization and endocytosis. Recently determined cryo-EM structures of two different GPCRs in complex with βarr1 provide the first glimpse of GPCR-βarr engagement and a structural framework to understand their interaction.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-12
      DOI: 10.1016/j.cell.2020.02.047
      Issue No: Vol. 180, No. 6 (2020)
       
  • Toll-like Receptors and the Control of Immunity
    • Authors: Katherine A. Fitzgerald; Jonathan C. Kagan
      Pages: 1044 - 1066
      Abstract: Kagan and Fitzgerald comprehensively review the functions and mechanisms of Toll-like receptors (TLRs), which are crucial detectors of microbial biomolecules and mediators of cellular immunity. They synthesize the overarching themes that have emerged from TLR signaling but are repeated throughout the pattern recognition receptor (PRR) superfamily.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-11
      DOI: 10.1016/j.cell.2020.02.041
      Issue No: Vol. 180, No. 6 (2020)
       
  • Propionic Acid Shapes the Multiple Sclerosis Disease Course by an
           Immunomodulatory Mechanism
    • Authors: Alexander Duscha; Barbara Gisevius, Sarah Hirschberg, Nissan Yissachar, Gabriele I. Stangl, Eva Eilers, Verian Bader, Stefanie Haase, Johannes Kaisler, Christina David, Ruth Schneider, Riccardo Troisi, Daniel Zent, Tobias Hegelmaier, Nikolaos Dokalis, Sara Gerstein, Sara Del Mare-Roumani, Sivan Amidror, Ori Staszewski, Gereon Poschmann, Kai Stühler, Frank Hirche, Andras Balogh, Stefan Kempa, Pascal Träger, Mario M. Zaiss, Jacob Bak Holm, Megan G. Massa, Henrik Bjørn Nielsen, Andreas Faissner, Carsten Lukas, Sören G. Gatermann, Markus Scholz, Horst Przuntek, Marco Prinz, Sofia K. Forslund, Konstanze F. Winklhofer, Dominik N. Müller, Ralf A. Linker, Ralf Gold, Aiden Haghikia
      Pages: 1067 - 1080.e16
      Abstract: Supplementation of the short-chain fatty acid propionic acid (PA) in multiple sclerosis (MS) patients reverses the Treg cell/Th17 cell imbalance via increased Treg cell induction and enhancement of Treg cell function and is associated with disease course improvement.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-10
      DOI: 10.1016/j.cell.2020.02.035
      Issue No: Vol. 180, No. 6 (2020)
       
  • Complement Signals Determine Opposite Effects of B Cells in
           Chemotherapy-Induced Immunity
    • Authors: Yiwen Lu; Qiyi Zhao, Jian-You Liao, Erwei Song, Qidong Xia, Jiayao Pan, Yihong Li, Jiaqian Li, Boxuan Zhou, Yingying Ye, Can Di, Shubin Yu, Yunjie Zeng, Shicheng Su
      Pages: 1081 - 1097.e24
      Abstract: An anti-tumoral B cell subset emerges in the tumor microenvironment in response to chemotherapy-induced immunogenic cell death and complement signaling.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-05
      DOI: 10.1016/j.cell.2020.02.015
      Issue No: Vol. 180, No. 6 (2020)
       
  • Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte
           Differentiation to Promote Immune Suppression
    • Authors: Samir Devalaraja; Tsun Ki Jerrick To, Ian W. Folkert, Ramakrishnan Natesan, Md Zahidul Alam, Minghong Li, Yuma Tada, Konstantin Budagyan, Mai T. Dang, Li Zhai, Graham P. Lobel, Gabrielle E. Ciotti, T.S. Karin Eisinger-Mathason, Irfan A. Asangani, Kristy Weber, M. Celeste Simon, Malay Haldar
      Pages: 1098 - 1114.e16
      Abstract: Tumor cells evade immune responses by producing high levels of retinoic acid, which directs intratumoral monocytes to differentiate into immunosuppressive macrophages rather than immunostimulatory dendritic cells.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-12
      DOI: 10.1016/j.cell.2020.02.042
      Issue No: Vol. 180, No. 6 (2020)
       
  • Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis
    • Authors: Ting Zhang; Chaoran Yin, David F. Boyd, Giovanni Quarato, Justin P. Ingram, Maria Shubina, Katherine B. Ragan, Takumi Ishizuka, Jeremy Chase Crawford, Bart Tummers, Diego A. Rodriguez, Jia Xue, Suraj Peri, William J. Kaiser, Carolina B. López, Yan Xu, Jason W. Upton, Paul G. Thomas, Douglas R. Green, Siddharth Balachandran
      Pages: 1115 - 1129.e13
      Abstract: Z-RNAs produced by influenza viruses in the nucleus of infected cells are detected by host ZBP1, which activates RIPK3 and MLKL to lead to nuclear envelope rupture and necroptosis, ultimately resulting in neutrophil recruitment and activation in infected tissue.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.050
      Issue No: Vol. 180, No. 6 (2020)
       
  • Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase
    • Authors: Kashish Singh; Benjamin Graf, Andreas Linden, Viktor Sautner, Henning Urlaub, Kai Tittmann, Holger Stark, Ashwin Chari
      Pages: 1130 - 1143.e20
      Abstract: Structural analysis identifies a new regulator of yeast fatty acid synthase.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-10
      DOI: 10.1016/j.cell.2020.02.034
      Issue No: Vol. 180, No. 6 (2020)
       
  • Liquid-Liquid Phase Transition Drives Intra-chloroplast Cargo Sorting
    • Authors: Min Ouyang; Xiaoyi Li, Jing Zhang, Peiqiang Feng, Hua Pu, Lingxi Kong, Zechen Bai, Liwei Rong, Xiumei Xu, Wei Chi, Qiang Wang, Fan Chen, Congming Lu, Jianren Shen, Lixin Zhang
      Pages: 1144 - 1159.e20
      Abstract: A pair of ankyrin repeat proteins in chloroplasts recognizes signal peptides on thylakoid-bound cargo proteins and undergoes liquid-liquid phase separation to facilitate their sorting and transport.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-12
      DOI: 10.1016/j.cell.2020.02.045
      Issue No: Vol. 180, No. 6 (2020)
       
  • A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial
           Metabolism and ER-Resident UFMylation
    • Authors: Jin Rui Liang; Emily Lingeman, Thao Luong, Saba Ahmed, Matthias Muhar, Truc Nguyen, James A. Olzmann, Jacob E. Corn
      Pages: 1160 - 1177.e20
      Abstract: An unbiased, genome-wide screen implicates mitochondrial oxidative phosphorylation and ER surface UFMylation as regulators of starvation-induced ER-phagy.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-10
      DOI: 10.1016/j.cell.2020.02.017
      Issue No: Vol. 180, No. 6 (2020)
       
  • Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social
           Behavior Deficits
    • Authors: Alexandros K. Kanellopoulos; Vittoria Mariano, Marco Spinazzi, Young Jae Woo, Colin McLean, Ulrike Pech, Ka Wan Li, J. Douglas Armstrong, Angela Giangrande, Patrick Callaerts, August B. Smit, Brett S. Abrahams, Andre Fiala, Tilmann Achsel, Claudia Bagni
      Pages: 1178 - 1197.e20
      Abstract: A Drosophila model of CYFIP1 haploinsufficiency, a genetic variant linked to schizophrenia and autism, reveals that increased mitochondrial activity and membrane potential reduces GABA availability and plays a causal role in mediating social behavioral abnormalities.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.044
      Issue No: Vol. 180, No. 6 (2020)
       
  • Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+
           Progenitors
    • Authors: Daisong Wang; Jingqiang Wang, Lanyue Bai, Hong Pan, Hua Feng, Hans Clevers, Yi Arial Zeng
      Pages: 1198 - 1211.e19
      Abstract: Identification of a lineage of progenitor cells in the adult pancreas that can give rise to all four endocrine cell types and be cultured to functional pancreatic islet organoids that contain mature β cells and can reverse diabetes in mice upon transplantation.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.048
      Issue No: Vol. 180, No. 6 (2020)
       
  • Initiation of Parental Genome Reprogramming in Fertilized Oocyte by
           Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation
    • Authors: Lan-Tao Gou; Do-Hwan Lim, Wubin Ma, Brandon E. Aubol, Yajing Hao, Xin Wang, Jun Zhao, Zhengyu Liang, Changwei Shao, Xuan Zhang, Fan Meng, Hairi Li, Xiaorong Zhang, Ruiming Xu, Dangsheng Li, Michael G. Rosenfeld, Pamela L. Mellon, Joseph A. Adams, Mo-Fang Liu, Xiang-Dong Fu
      Pages: 1212 - 1227.e14
      Abstract: Upon fertilization, protamines that tightly pack DNA into sperm are phosphorylated by SRPK1, triggering DNA decondensation, protamine removal, and histone deposition.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-12
      DOI: 10.1016/j.cell.2020.02.020
      Issue No: Vol. 180, No. 6 (2020)
       
  • Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled
           Repair
    • Authors: Yuka Nakazawa; Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada, Kana Kato, Nan Jia, Satoru Hashimoto, Yuko Kotani, Yuka Miyoshi, Miyako Tanaka, Akira Sobue, Norisato Mitsutake, Takayoshi Suganami, Akio Masuda, Kinji Ohno, Shinichiro Nakada, Tomoji Mashimo, Koji Yamanaka, Martijn S. Luijsterburg, Tomoo Ogi
      Pages: 1228 - 1244.e24
      Abstract: Ubiquitination of RNA polymerase promotes recruitment of TFIIH and initiation of transcription-coupled repair, and dysregulation of this process in mice has neurological consequences akin to Cockayne syndrome.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-05
      DOI: 10.1016/j.cell.2020.02.010
      Issue No: Vol. 180, No. 6 (2020)
       
  • Regulation of the RNAPII Pool Is Integral to the DNA Damage Response
    • Authors: Ana Tufegdžić Vidaković; Richard Mitter, Gavin P. Kelly, Michelle Neumann, Michelle Harreman, Marta Rodríguez-Martínez, Anna Herlihy, Juston C. Weems, Stefan Boeing, Vesela Encheva, Liam Gaul, Laura Milligan, David Tollervey, Ronald C. Conaway, Joan W. Conaway, Ambrosius P. Snijders, Aengus Stewart, Jesper Q. Svejstrup
      Pages: 1245 - 1261.e21
      Abstract: Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-05
      DOI: 10.1016/j.cell.2020.02.009
      Issue No: Vol. 180, No. 6 (2020)
       
  • Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of
           Human Enhancer Variants
    • Authors: Evgeny Z. Kvon; Yiwen Zhu, Guy Kelman, Catherine S. Novak, Ingrid Plajzer-Frick, Momoe Kato, Tyler H. Garvin, Quan Pham, Anne N. Harrington, Riana D. Hunter, Janeth Godoy, Eman M. Meky, Jennifer A. Akiyama, Veena Afzal, Stella Tran, Fabienne Escande, Brigitte Gilbert-Dussardier, Nolwenn Jean-Marçais, Sanjarbek Hudaiberdiev, Ivan Ovcharenko, Matthew B. Dobbs, Christina A. Gurnett, Sylvie Manouvrier-Hanu, Florence Petit, Axel Visel, Diane E. Dickel, Len A. Pennacchio
      Pages: 1262 - 1271.e15
      Abstract: Development of a scalable in vivo mouse enhancer-reporter assay and its use to systematically interrogate the canonical human ZRS enhancer, which drives Sonic hedgehog expression in mammalian limb development, broadly illuminates enhancer variant pathogenicity.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-12
      DOI: 10.1016/j.cell.2020.02.031
      Issue No: Vol. 180, No. 6 (2020)
       
  • Relaxed Selection Limits Lifespan by Increasing Mutation Load
    • Authors: Rongfeng Cui; Tania Medeiros, David Willemsen, Leonardo N.M. Iasi, Glen E. Collier, Martin Graef, Martin Reichard, Dario Riccardo Valenzano
      Pages: 1272 - 1279
      Abstract: (Cell 178, 385–399.e1–e20; July 11, 2019)
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.038
      Issue No: Vol. 180, No. 6 (2020)
       
  • SnapShot: Natural Killer Cells
    • Authors: Adeline Crinier; Emilie Narni-Mancinelli, Sophie Ugolini, Eric Vivier
      Pages: 1280 - 1280.e1
      Abstract: NK cells are broadly distributed innate lymphoid cells (ILCs) encompassing distinct populations based on CD11b and CD27 expression in mice or CD56 intensity in humans. Involved in anti-viral and anti-tumor immunity thanks to their cytokines and chemokines secretion as well as their cytotoxic capabilities, NK cells have emerged as a promising therapeutic target in several solid tumors and hematological malignancies. To view this Snapshot, open or download the PDF.
      Citation: Cell 180, 6 (2020)
      PubDate: 2020-03-19
      DOI: 10.1016/j.cell.2020.02.029
      Issue No: Vol. 180, No. 6 (2020)
       
 
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