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Journal Cover
Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1081  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3161 journals]
  • The Perfect Appetizer: A Pharmacological Strategy for a Non-biting
           Mosquito
    • Authors: João S.M. Gesto; Luciano A. Moreira
      Pages: 679 - 681
      Abstract: New possibilities for vector-borne disease control are revealed by Duvall et al. (2019), who link host-seeking behavioral modulation in Aedes aegypti to neuropeptide Y (NPY)-like receptor 7. Small-molecule screening yields agonist compounds able to activate NPYLR7 and suppress attraction to hosts.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.032
      Issue No: Vol. 176, No. 4 (2019)
       
  • Replication Timing Becomes Intertwined with 3D Genome Organization
    • Authors: Jian Ma; Zhijun Duan
      Pages: 681 - 684
      Abstract: Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization. The study has important implications for unraveling control elements of high-order genome structure and function.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.027
      Issue No: Vol. 176, No. 4 (2019)
       
  • Designer Assays for Your Sick, Subdivided Heart
    • Authors: Kevin Kit Parker
      Pages: 684 - 685
      Abstract: Using induced pluripotent stem cells and microelectromechanical device technology Zhao et al. have developed ‘organs on chips’ representing the different chambers of the heart and used them to replicate healthy and diseased tissues in vitro. These systems offer investigators and the pharmaceutical industry a new tool in testing the safety and efficacy of new medicinal therapeutics.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.028
      Issue No: Vol. 176, No. 4 (2019)
       
  • Small-Molecule Agonists of Ae. aegypti Neuropeptide Y Receptor Block
           Mosquito Biting
    • Authors: Laura B. Duvall; Lavoisier Ramos-Espiritu, Kyrollos E. Barsoum, J. Fraser Glickman, Leslie B. Vosshall
      Pages: 687 - 701.e5
      Abstract: Mosquito-specific compounds that perturb NPY signaling in Aedes aegypti alter its host-seeking behavior and may serve as a new approach to control infectious disease transmission.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2018.12.004
      Issue No: Vol. 176, No. 4 (2019)
       
  • Establishing Cerebral Organoids as Models of Human-Specific Brain
           Evolution
    • Authors: Alex A. Pollen; Aparna Bhaduri, Madeline G. Andrews, Tomasz J. Nowakowski, Olivia S. Meyerson, Mohammed A. Mostajo-Radji, Elizabeth Di Lullo, Beatriz Alvarado, Melanie Bedolli, Max L. Dougherty, Ian T. Fiddes, Zev N. Kronenberg, Joe Shuga, Anne A. Leyrat, Jay A. West, Marina Bershteyn, Craig B. Lowe, Bryan J. Pavlovic, Sofie R. Salama, David Haussler, Evan E. Eichler, Arnold R. Kriegstein
      Pages: 743 - 756.e17
      Abstract: Comparisons of cerebral organoids between chimpanzees, macaques, and humans reveal gene duplications and cell-signaling alterations that explain developmental evolutionary differences that are unique to us as a species.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.017
      Issue No: Vol. 176, No. 4 (2019)
       
  • Widespread and Functional RNA Circularization in Localized Prostate Cancer
    • Authors: Sujun Chen; Vincent Huang, Xin Xu, Julie Livingstone, Fraser Soares, Jouhyun Jeon, Yong Zeng, Junjie Tony Hua, Jessica Petricca, Haiyang Guo, Miranda Wang, Fouad Yousif, Yuzhe Zhang, Nilgun Donmez, Musaddeque Ahmed, Stas Volik, Anna Lapuk, Melvin L.K. Chua, Lawrence E. Heisler, Adrien Foucal, Natalie S. Fox, Michael Fraser, Vinayak Bhandari, Yu-Jia Shiah, Jiansheng Guan, Jixi Li, Michèle Orain, Valérie Picard, Hélène Hovington, Alain Bergeron, Louis Lacombe, Yves Fradet, Bernard Têtu, Stanley Liu, Felix Feng, Xue Wu, Yang W. Shao, Malgorzata A. Komor, Cenk Sahinalp, Colin Collins, Youri Hoogstrate, Mark de Jong, Remond J.A. Fijneman, Teng Fei, Guido Jenster, Theodorus van der Kwast, Robert G. Bristow, Paul C. Boutros, Housheng Hansen He
      Pages: 831 - 843.e22
      Abstract: RNA circularization is a pervasive feature of prostate cancer, with hundreds of circRNAs promoting cell proliferation through functions distinct from their parental linear RNA.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.025
      Issue No: Vol. 176, No. 4 (2019)
       
  • Pollen Cell Wall Patterns Form from Modulated Phases
    • Authors: Asja Radja; Eric M. Horsley, Maxim O. Lavrentovich, Alison M. Sweeney
      Pages: 856 - 868.e10
      Abstract: A biophysical model explains the non-equilibrium phase-separation properties in polysaccharides that form distinct, characteristic patterns on the surface of pollen grains across the diversity of plants.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.014
      Issue No: Vol. 176, No. 4 (2019)
       
  • The Landscape of Circular RNA in Cancer
    • Authors: Josh N. Vo; Marcin Cieslik, Yajia Zhang, Sudhanshu Shukla, Lanbo Xiao, Yuping Zhang, Yi-Mi Wu, Saravana M. Dhanasekaran, Carl G. Engelke, Xuhong Cao, Dan R. Robinson, Alexey I. Nesvizhskii, Arul M. Chinnaiyan
      Pages: 869 - 881.e13
      Abstract: MiOncoCirc provides a reference of the circular RNA landscape across 40 cancer types.
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2018.12.021
      Issue No: Vol. 176, No. 4 (2019)
       
  • Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible
           Cause of Vascular Aging
    • Authors: Abhirup Das; George X. Huang, Michael S. Bonkowski, Alban Longchamp, Catherine Li, Michael B. Schultz, Lynn-Jee Kim, Brenna Osborne, Sanket Joshi, Yuancheng Lu, Jose Humberto Treviño-Villarreal, Myung-Jin Kang, Tzong-tyng Hung, Brendan Lee, Eric O. Williams, Masaki Igarashi, James R. Mitchell, Lindsay E. Wu, Nigel Turner, Zolt Arany, Leonard Guarente, David A. Sinclair
      Pages: 944 - 945
      Abstract: (Cell 173, 74–89.e1–e21; March 22, 2018)
      Citation: Cell 176, 4 (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.026
      Issue No: Vol. 176, No. 4 (2019)
       
  • The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy
    • Authors: Rastislav Horos; Magdalena Büscher, Rozemarijn Kleinendorst, Anne-Marie Alleaume, Abul K. Tarafder, Thomas Schwarzl, Dmytro Dziuba, Christian Tischer, Elisabeth M. Zielonka, Asli Adak, Alfredo Castello, Wolfgang Huber, Carsten Sachse, Matthias W. Hentze
      Abstract: A biological function of vault RNAs is to directly modulate the oligomerization state of p62, thereby controlling autophagy.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2019.01.030
       
  • Sexually Dimorphic Control of Parenting Behavior by the Medial Amygdala
    • Authors: Patrick B. Chen; Rongfeng K. Hu, Ye Emily Wu, Lin Pan, Shan Huang, Paul E. Micevych, Weizhe Hong
      Abstract: Sexually dimorphic displays of parenting and infanticide are differentially controlled by GABAergic neurons in the medial amygdala in an activity level-dependent manner. Single-cell transcriptomic analysis reveals cell type-specific molecular sex differences in GABAergic neurons, highlighting a connection between sexual dimorphism at levels of molecules, cells, circuits, and behavior.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2019.01.024
       
  • Error-Prone Replication through UV Lesions by DNA Polymerase θ
           Protects against Skin Cancers
    • Authors: Jung-Hoon Yoon; Mark J. McArthur, Jeseong Park, Debashree Basu, Maki Wakamiya, Louise Prakash, Satya Prakash
      Abstract: Both error-free TLS by DNA polymerase η and error-prone TLS by DNA polymerase θ through UV lesions protect against replication stress-induced chromosomal instability and prevent skin cancer formation.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2019.01.023
       
  • Lateral Inhibition in Cell Specification Mediated by Mechanical Signals
           Modulating TAZ Activity
    • Authors: Peng Xia; Daniel Gütl, Vanessa Zheden, Carl-Philipp Heisenberg
      Abstract: Specification of a single precursor cell fate in zebrafish oogenesis is mediated by lateral inhibition driven by mechanical forces that lead to nuclear exclusion of a developmental transcriptional activator in neighboring cells.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2019.01.019
       
  • The Root Cap Cuticle: A Cell Wall Structure for Seedling Establishment and
           Lateral Root Formation
    • Authors: Alice Berhin; Damien de Bellis, Rochus B. Franke, Rafael A. Buono, Moritz K. Nowack, Christiane Nawrath
      Abstract: A cuticle-like cell wall structure on plant root caps protects seedlings from abiotic stress and contributes to proper lateral root outgrowth.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2019.01.005
       
  • A Hippocampus-Accumbens Tripartite Neuronal Motif Guides Appetitive Memory
           in Space
    • Authors: Stéphanie Trouche; Vadim Koren, Natalie M. Doig, Tommas J. Ellender, Mohamady El-Gaby, Vítor Lopes-dos-Santos, Hayley M. Reeve, Pavel V. Perestenko, Farid N. Garas, Peter J. Magill, Andrew Sharott, David Dupret
      Abstract: Retrieving and acting on memories of food-predicting environments are fundamental processes for animal survival. Trouche et al. show in mice that the behavioral manifestation of spatial appetitive memory requires a direct neural pathway from dorsal hippocampus to nucleus accumbens. This pathway engages dCA1 with a select population of accumbens parvalbumin-expressing fast-spiking interneurons, thereby sculpting the assembly activity of its postsynaptic medium-sized spiny neurons. An indirect pathway through dorsal subiculum is dispensable for appetitive memory but contributes to spatial novelty detection.
      Citation: Cell (2019)
      PubDate: 2019-02-14
      DOI: 10.1016/j.cell.2018.12.037
       
  • Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by
           Dot1L
    • Authors: Evan J. Worden; Niklas A. Hoffmann, Chad W. Hicks, Cynthia Wolberger
      Abstract: Unanticipated conformational plasticity in the globular core of histone H3 underlies cross-talk between histone modifications.
      Citation: Cell (2019)
      PubDate: 2019-02-11
      DOI: 10.1016/j.cell.2019.02.002
       
  • Co-targeting RNA Polymerases IV and V Promotes Efficient De Novo DNA
           Methylation in Arabidopsis
    • Authors: Javier Gallego-Bartolomé; Wanlu Liu, Peggy Hsuanyu Kuo, Suhua Feng, Basudev Ghoshal, Jason Gardiner, Jenny Miao-Chi Zhao, Soo Young Park, Joanne Chory, Steven E. Jacobsen
      Abstract: Comprehensive investigation into the genetic pathway of RNA-directed DNA methylation in Arabidopsis defines epistatic relationships and allows for efficient manipulation of DNA methylation to specifically modify developmental phenotypes.
      Citation: Cell (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.029
       
  • Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to
           Senescence
    • Authors: Gabriel E. Neurohr; Rachel L. Terry, Jette Lengefeld, Megan Bonney, Gregory P. Brittingham, Fabien Moretto, Teemu P. Miettinen, Laura Pontano Vaites, Luis M. Soares, Joao A. Paulo, J. Wade Harper, Stephen Buratowski, Scott Manalis, Folkert J. van Werven, Liam J. Holt, Angelika Amon
      Abstract: Optimal cell function requires maintenance of a narrow range of DNA:cytoplasm ratios and when cell size exceeds this ratio cytoplasmic dilution contributes to senescence
      Citation: Cell (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2019.01.018
       
  • Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in
           Celiac Disease
    • Authors: Toufic Mayassi; Kristin Ladell, Herman Gudjonson, James E. McLaren, Dustin G. Shaw, Mai T. Tran, Jagoda J. Rokicka, Ian Lawrence, Jean-Christophe Grenier, Vincent van Unen, Cezary Ciszewski, Matthew Dimaano, Hoda E. Sayegh, Vinod Kumar, Cisca Wijmenga, Peter H.R. Green, Ranjana Gokhale, Hilary Jericho, Carol E. Semrad, Stefano Guandalini, Aaron R. Dinner, Sonia S. Kupfer, Hugh H. Reid, Luis B. Barreiro, Jamie Rossjohn, David A. Price, Bana Jabri
      Abstract: Chronic inflammation, driven in the context of celiac disease by persistent antigenic challenge with dietary gluten, permanently reshapes the tissue-resident innate-like TCRγδ+ intraepithelial lymphocyte compartment.
      Citation: Cell (2019)
      PubDate: 2019-02-07
      DOI: 10.1016/j.cell.2018.12.039
       
  • Molecular Classification and Comparative Taxonomics of Foveal and
           Peripheral Cells in Primate Retina
    • Authors: Yi-Rong Peng; Karthik Shekhar, Wenjun Yan, Dustin Herrmann, Anna Sappington, Gregory S. Bryman, Tavé van Zyl, Michael Tri. H. Do, Aviv Regev, Joshua R. Sanes
      Abstract: Single-cell-based analysis provides a comprehensive molecular and cellular taxonomy of the primate retina.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2019.01.004
       
  • Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven
           Melanomagenesis
    • Authors: Chengqian Yin; Bo Zhu, Ting Zhang, Tongzheng Liu, Shuyang Chen, Yu Liu, Xin Li, Xiao Miao, Shanshan Li, Xia Mi, Jie Zhang, Li Li, Guo Wei, Zhi-xiang Xu, Xiumei Gao, Canhua Huang, Zhi Wei, Colin R. Goding, Peng Wang, Xianming Deng, Rutao Cui
      Abstract: Pharmacological inhibition of the NRAS activator STK19 is a promising therapeutic option for the treatment of melanoma.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2019.01.002
       
  • Molecular Discrimination between Two Conformations of Sphingomyelin in
           Plasma Membranes
    • Authors: Shreya Endapally; Donna Frias, Magdalena Grzemska, Austin Gay, Diana R. Tomchick, Arun Radhakrishnan
      Abstract: The plasma membrane lipid sphingomyelin has two distinct conformations depending on the presence or absence of cholesterol.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.042
       
  • Limbic Neurons Shape Sex Recognition and Social Behavior in Sexually Naive
           Males
    • Authors: Daniel W. Bayless; Taehong Yang, Matthew M. Mason, Albert A.T. Susanto, Alexandra Lobdell, Nirao M. Shah
      Abstract: Aromatase-expressing BNSTpr neurons govern sex recognition and social behavior in naive male mice.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.041
       
  • Commensal Microbiota Promote Lung Cancer Development via γδ T
           Cells
    • Authors: Chengcheng Jin; Georgia K. Lagoudas, Chen Zhao, Susan Bullman, Arjun Bhutkar, Bo Hu, Samuel Ameh, Demi Sandel, Xu Sue Liang, Sarah Mazzilli, Mark T. Whary, Matthew Meyerson, Ronald Germain, Paul C. Blainey, James G. Fox, Tyler Jacks
      Abstract: Lung cancer development is associated with increased bacterial burden and altered bacterial composition in the lung. Depletion of microbiota or blockade of the downstream cellular or molecular immune mediators significantly suppress lung tumor growth.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.040
       
  • Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates
           Commensal Bacteria Equilibrium
    • Authors: Tetsuro Kobayashi; Benjamin Voisin, Do Young Kim, Elizabeth A. Kennedy, Jay-Hyun Jo, Han-Yu Shih, Amanda Truong, Thomas Doebel, Keiko Sakamoto, Chang-Yi Cui, David Schlessinger, Kazuyo Moro, Susumu Nakae, Keisuke Horiuchi, Jinfang Zhu, Warren J. Leonard, Heidi H. Kong, Keisuke Nagao
      Abstract: Skin innate lymphoid cell subsets rely on hair follicle-derived factors for persistence and localization and tune the skin microbiota by controlling sebaceous gland function.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.031
       
  • Identification of Enteroendocrine Regulators by Real-Time Single-Cell
           Differentiation Mapping
    • Authors: Helmuth Gehart; Johan H. van Es, Karien Hamer, Joep Beumer, Kai Kretzschmar, Johanna F. Dekkers, Anne Rios, Hans Clevers
      Abstract: The hierarchical lineage of intestinal enteroendocrine cells is defined at a spatiotemporal single-cell manner and validated using organoid and in vivo models.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.029
       
  • Unexpected Receptor Functional Mimicry Elucidates Activation of
           Coronavirus Fusion
    • Authors: Alexandra C. Walls; Xiaoli Xiong, Young-Jun Park, M. Alejandra Tortorici, Joost Snijder, Joel Quispe, Elisabetta Cameroni, Robin Gopal, Mian Dai, Antonio Lanzavecchia, Maria Zambon, Félix A. Rey, Davide Corti, David Veesler
      Abstract: Structural analysis of the SARS-CoV S and MERS-CoV S glycoproteins in complex with neutralizing antibodies from human survivors sheds light into the mechanisms of membrane fusion and neutralization
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.028
       
  • Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
    • Authors: Hui Xu; Tianbo Li, Alexis Rohou, Christopher P. Arthur, Foteini Tzakoniati, Evera Wong, Alberto Estevez, Christine Kugel, Yvonne Franke, Jun Chen, Claudio Ciferri, David H. Hackos, Christopher M. Koth, Jian Payandeh
      First page: 702
      Abstract: Seeing how a spider toxin blocks a sodium channel suggests a structural basis for channel gating and avenues for developing new modulators.
      Citation: Cell (2019)
      PubDate: 2019-01-17
      DOI: 10.1016/j.cell.2018.12.018
       
  • Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve
           Injury
    • Authors: Alexander J. Davies; Hyoung Woo Kim, Rafael Gonzalez-Cano, Jahyang Choi, Seung Keun Back, Seung Eon Roh, Errin Johnson, Melanie Gabriac, Mi-Sun Kim, Jaehee Lee, Jeong Eun Lee, Yun Sook Kim, Yong Chul Bae, Sang Jeong Kim, Kyung-Mi Lee, Heung Sik Na, Priscilla Riva, Alban Latremoliere, Simon Rinaldi, Sophie Ugolini, Michael Costigan, Seog Bae Oh
      First page: 716
      Abstract: Pain following nerve damage can be mitigated by cytotoxic natural killer cells that selectively clear out partially damaged nerves.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.022
       
  • Human Semaphorin 3 Variants Link Melanocortin Circuit Development and
           Energy Balance
    • Authors: Agatha A. van der Klaauw; Sophie Croizier, Edson Mendes de Oliveira, Lukas K.J. Stadler, Soyoung Park, Youxin Kong, Matthew C. Banton, Panna Tandon, Audrey E. Hendricks, Julia M. Keogh, Susanna E. Riley, Sofia Papadia, Elana Henning, Rebecca Bounds, Elena G. Bochukova, Vanisha Mistry, Stephen O’Rahilly, Richard B. Simerly, INTERVAL, UK10K Consortium, James E.N. Minchin, Inês Barroso, E. Yvonne Jones, Sebastien G. Bouret, I. Sadaf Farooqi
      First page: 729
      Abstract: Semaphorin 3 signaling promotes the development of hypothalamic circuits, and human variants are associated with obesity.
      Citation: Cell (2019)
      PubDate: 2019-01-17
      DOI: 10.1016/j.cell.2018.12.009
       
  • Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression
           via a Secretory Cross-Talk with the Immune Microenvironment
    • Authors: Mirella Georgouli; Cecilia Herraiz, Eva Crosas-Molist, Bruce Fanshawe, Oscar Maiques, Anna Perdrix, Pahini Pandya, Irene Rodriguez-Hernandez, Kristina M. Ilieva, Gaia Cantelli, Panagiotis Karagiannis, Silvia Mele, Hoyin Lam, Debra H. Josephs, Xavier Matias-Guiu, Rosa M. Marti, Frank O. Nestle, Jose L. Orgaz, Ilaria Malanchi, Gilbert O. Fruhwirth, Sophia N. Karagiannis, Victoria Sanz-Moreno
      First page: 757
      Abstract: Myosin II activation at the tumor edge promotes invasion and also a secretory phenotype that reshapes the local environment and vasculature to support tumor growth.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2018.12.038
       
  • A Peninsular Structure Coordinates Asynchronous Differentiation with
           Morphogenesis to Generate Pancreatic Islets
    • Authors: Nadav Sharon; Raghav Chawla, Jonas Mueller, Jordan Vanderhooft, Luke James Whitehorn, Benjamin Rosenthal, Mads Gürtler, Ralph R. Estanboulieh, Dmitry Shvartsman, David K. Gifford, Cole Trapnell, Doug Melton
      First page: 790
      Abstract: Single-cell spatiotemporal studies of the developing pancreas reveal a tight link between morphology and endocrine cell differentiation, with α and β cells forming layered peninsular structures.
      Citation: Cell (2019)
      PubDate: 2019-01-17
      DOI: 10.1016/j.cell.2018.12.003
       
  • Importin α Partitioning to the Plasma Membrane Regulates
           Intracellular Scaling
    • Authors: Christopher Brownlee; Rebecca Heald
      First page: 805
      Abstract: A modified form of the protein importin α regulates the scaling of intracellular structures concomitant with cell size.
      Citation: Cell ()
      PubDate: 2019-01-10
      DOI: 10.1016/j.cell.2018.12.001
       
  • Optimal Decoding of Cellular Identities in a Genetic Network
    • Authors: Mariela D. Petkova; Gašper Tkačik, William Bialek, Eric F. Wieschaus, Thomas Gregor
      First page: 844
      Abstract: The information to specify precise cellular identities is present and decoded at the earliest stages of Drosophila development, contrasting with the view that positional information is slowly refined across successive patterning layers.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2019.01.007
       
  • Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk
           between Activation and Differentiation
    • Authors: Johan Henriksson; Xi Chen, Tomás Gomes, Ubaid Ullah, Kerstin B. Meyer, Ricardo Miragaia, Graham Duddy, Jhuma Pramanik, Kosuke Yusa, Riitta Lahesmaa, Sarah A. Teichmann
      First page: 882
      Abstract: A CRISPR-based screen reveals gene networks central to modulating multiple aspects of Th2 cell function.
      Citation: Cell (2019)
      PubDate: 2019-01-10
      DOI: 10.1016/j.cell.2018.11.044
       
  • The cis-Regulatory Atlas of the Mouse Immune System
    • Authors: Hideyuki Yoshida; Caleb A. Lareau, Ricardo N. Ramirez, Samuel A. Rose, Barbara Maier, Aleksandra Wroblewska, Fiona Desland, Aleksey Chudnovskiy, Arthur Mortha, Claudia Dominguez, Julie Tellier, Edy Kim, Dan Dwyer, Susan Shinton, Tsukasa Nabekura, YiLin Qi, Bingfei Yu, Michelle Robinette, Ki-Wook Kim, Amy Wagers, Andrew Rhoads, Stephen L. Nutt, Brian D. Brown, Sara Mostafavi, Jason D. Buenrostro, Christophe Benoist, the Immunological Genome Project
      First page: 897
      Abstract: A cis-regulatory map of the mouse immune system illuminates gene expression patterns and regulatory logic across 86 primary cell types and pairs immune transcription factors with cell-type-specific regulatory elements.
      Citation: Cell (2019)
      PubDate: 2019-01-24
      DOI: 10.1016/j.cell.2018.12.036
       
  • A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease
           Modeling
    • Authors: Yimu Zhao; Naimeh Rafatian, Nicole T. Feric, Brian J. Cox, Roozbeh Aschar-Sobbi, Erika Yan Wang, Praful Aggarwal, Boyang Zhang, Genevieve Conant, Kacey Ronaldson-Bouchard, Aric Pahnke, Stephanie Protze, Jee Hoon Lee, Locke Davenport Huyer, Danica Jekic, Anastasia Wickeler, Hani E. Naguib, Gordon M. Keller, Gordana Vunjak-Novakovic, Ulrich Broeckel, Peter H. Backx, Milica Radisic
      First page: 913
      Abstract: A scalable cardiac tissue cultivation platform enables assessment of multiple parameters of atrial and ventricular tissue function, drug testing, and disease modeling.
      Citation: Cell (2019)
      PubDate: 2019-01-24
      DOI: 10.1016/j.cell.2018.11.042
       
  • Optimal-Transport Analysis of Single-Cell Gene Expression Identifies
           Developmental Trajectories in Reprogramming
    • Authors: Geoffrey Schiebinger; Jian Shu, Marcin Tabaka, Brian Cleary, Vidya Subramanian, Aryeh Solomon, Joshua Gould, Siyan Liu, Stacie Lin, Peter Berube, Lia Lee, Jenny Chen, Justin Brumbaugh, Philippe Rigollet, Konrad Hochedlinger, Rudolf Jaenisch, Aviv Regev, Eric S. Lander
      First page: 928
      Abstract: Application of a new analytical approach to examine developmental trajectories of single cells offers insight into how paracrine interactions shape reprogramming.
      Citation: Cell (2019)
      PubDate: 2019-01-31
      DOI: 10.1016/j.cell.2019.01.006
       
  • Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated
           Compartment within Human Melanoma
    • Authors: Hanjie Li; Anne M. van der Leun, Ido Yofe, Yaniv Lubling, Dikla Gelbard-Solodkin, Alexander C.J. van Akkooi, Marlous van den Braber, Elisa A. Rozeman, John B.A.G. Haanen, Christian U. Blank, Hugo M. Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N. Schumacher, Amos Tanay, Ido Amit
      First page: 775
      Abstract: Single-cell analysis of melanoma tumor immune infiltrates reveals a separation between bystander cytotoxic T cells and a population that displays a continuous progression from a transitional toward a dysfunctional state that is associated with active proliferation and tumor reactivity.
      Citation: Cell (2018)
      PubDate: 2018-12-27
      DOI: 10.1016/j.cell.2018.11.043
       
  • Identifying cis Elements for Spatiotemporal Control of Mammalian DNA
           Replication
    • Authors: Jiao Sima; Abhijit Chakraborty, Vishnu Dileep, Marco Michalski, Kyle N. Klein, Nicolas P. Holcomb, Jesse L. Turner, Michelle T. Paulsen, Juan Carlos Rivera-Mulia, Claudia Trevilla-Garcia, Daniel A. Bartlett, Peiyao A. Zhao, Brian K. Washburn, Elphège P. Nora, Katerina Kraft, Stefan Mundlos, Benoit G. Bruneau, Mats Ljungman, Peter Fraser, Ferhat Ay, David M. Gilbert
      First page: 816
      Abstract: cis-regulatory elements control the three-dimensional compartmentalization, architecture of the genome, and replication timing in a CTCF-independent manner.
      Citation: Cell (2018)
      PubDate: 2018-12-27
      DOI: 10.1016/j.cell.2018.11.036
       
  • Plasticity of the Electrical Connectome of C. elegans
    • Authors: Abhishek Bhattacharya; Ulkar Aghayeva, Emily G. Berghoff, Oliver Hobert
      Abstract: Mapping the electrical connectome of C. elegans reveals the combinatorial patterns of synaptic protein expression that dictate behaviors associated with the physiological state of the animal.
      Citation: Cell ()
      DOI: 10.1016/j.cell.2018.12.024
       
  • A Unique Collateral Artery Development Program Promotes Neonatal Heart
           Regeneration
    • Authors: Soumyashree Das; Andrew B. Goldstone, Hanjay Wang, Justin Farry, Gaetano D’Amato, Michael J. Paulsen, Anahita Eskandari, Camille E. Hironaka, Ragini Phansalkar, Bikram Sharma, Siyeon Rhee, Elya Ali Shamskhou, Dritan Agalliu, Vinicio de Jesus Perez, Y. Joseph Woo, Kristy Red-Horse
      Abstract: A neonatal regenerative pathway involving migration of arterial endothelial cells to build collateral arteries that can provide blood flow under conditions of infarction or vascular occlusion has the potential to be harnessed for adult ischemic heart disease.
      Citation: Cell ()
      DOI: 10.1016/j.cell.2018.12.023
       
 
 
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