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Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1115  
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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3158 journals]
  • “Cloaking” on Time: A Cover-Up Act by Resident Tissue
    • Authors: Camille Blériot; Lai Guan Ng, Florent Ginhoux
      Pages: 514 - 516
      Abstract: In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell “macrolesions” are characteristically pro-inflammatory, resident macrophages can “cloak” single-cell microlesions to prevent excessive neutrophil recruitment and limit subsequent tissue damage.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.042
      Issue No: Vol. 177, No. 3 (2019)
  • Hear Pancreatic Cancer Stem Cells ROR
    • Authors: Wantong Yao; Anirban Maitra
      Pages: 516 - 518
      Abstract: In this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.04.002
      Issue No: Vol. 177, No. 3 (2019)
  • Polygenic Risk Scores Expand to Obesity
    • Authors: Ali Torkamani; Eric Topol
      Pages: 518 - 520
      Abstract: Obesity is one of the most serious health challenges of our time. In this issue of Cell, Khera and co-authors demonstrate the striking ability of genetics, in the form of a polygenic risk score, to identify those individuals at high risk for obesity. This genetic risk expresses itself early as childhood obesity, reinforcing the notion that early prevention is essential to combatting the obesity epidemic.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.051
      Issue No: Vol. 177, No. 3 (2019)
  • The Least Mating Pathway: Synthetically Refactoring a Familiar Signaling
           System for New Applications
    • Authors: Ronan W. O’Connell; Caleb J. Bashor
      Pages: 521 - 523
      Abstract: Synthetic refactoring makes naturally occurring regulatory systems more amenable to manipulation by removing or recoding their natural genetic complexity. Shaw et al. apply this technique to the yeast mating response pathway, creating a simplified, highly engineerable signaling module that can be used to construct precisely optimized, application-specific GPCR biosensors.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.04.003
      Issue No: Vol. 177, No. 3 (2019)
  • B Cell Responses: Cell Interaction Dynamics and Decisions
    • Authors: Jason G. Cyster; Christopher D.C. Allen
      Pages: 524 - 540
      Abstract: This Review provides a comprehensive overview of our current understanding of B cells and the antibodies they produce, at the cellular and molecular level, and their roles in protective immunity and disease.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.016
      Issue No: Vol. 177, No. 3 (2019)
  • Polygenic Prediction of Weight and Obesity Trajectories from Birth to
    • Authors: Amit V. Khera; Mark Chaffin, Kaitlin H. Wade, Sohail Zahid, Joseph Brancale, Rui Xia, Marina Distefano, Ozlem Senol-Cosar, Mary E. Haas, Alexander Bick, Krishna G. Aragam, Eric S. Lander, George Davey Smith, Heather Mason-Suares, Myriam Fornage, Matthew Lebo, Nicholas J. Timpson, Lee M. Kaplan, Sekar Kathiresan
      Pages: 587 - 596.e9
      Abstract: A genome-wide polygenic score quantifies inherited susceptibility to obesity, integrating information from 2.1 million common genetic variants to identify adults at risk of severe obesity.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.028
      Issue No: Vol. 177, No. 3 (2019)
  • Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect
           against Obesity
    • Authors: Luca A. Lotta; Jacek Mokrosiński, Edson Mendes de Oliveira, Chen Li, Stephen J. Sharp, Jian’an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D. Stewart, Eleanor Wheeler, Felix R. Day, John R.B. Perry, Claudia Langenberg, Nicholas J. Wareham, I. Sadaf Farooqi
      Pages: 597 - 607.e9
      Abstract: Gain-of-function genetic variants in the Melanocortin-4 Receptor associated with protection against obesity exhibit signaling bias for the recruitment of β-arrestin rather than canonical Gαs-mediated cAMP production.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.044
      Issue No: Vol. 177, No. 3 (2019)
  • SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in
           Long-Lived Species
    • Authors: Xiao Tian; Denis Firsanov, Zhihui Zhang, Yang Cheng, Lingfeng Luo, Gregory Tombline, Ruiyue Tan, Matthew Simon, Steven Henderson, Janine Steffan, Audrey Goldfarb, Jonathan Tam, Kitty Zheng, Adam Cornwell, Adam Johnson, Jiang-Nan Yang, Zhiyong Mao, Bruno Manta, Weiwei Dang, Zhengdong Zhang, Jan Vijg, Aaron Wolfe, Kelsey Moody, Brian K. Kennedy, Dirk Bohmann, Vadim N. Gladyshev, Andrei Seluanov, Vera Gorbunova
      Pages: 622 - 638.e22
      Abstract: A comparative analysis of 18 rodent species identifies a role for SIRT6-dependent DNA double strand break repair as a major factor in organismal lifespan
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.043
      Issue No: Vol. 177, No. 3 (2019)
  • Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls
           Proteasome Gene Expression
    • Authors: Nicolas J. Lehrbach; Peter C. Breen, Gary Ruvkun
      Pages: 737 - 750.e15
      Abstract: Post-translational protein sequence editing dependent on deglycosylation of N-glycosylated asparagine residues regulates proteasome function in C. elegans.
      Citation: Cell 177, 3 (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.035
      Issue No: Vol. 177, No. 3 (2019)
  • A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That
           Modulate Host Physiology
    • Authors: Haiwei Chen; Phu-Khat Nwe, Yi Yang, Connor E. Rosen, Agata A. Bielecka, Manik Kuchroo, Gary W. Cline, Andrew C. Kruse, Aaron M. Ring, Jason M. Crawford, Noah W. Palm
      Abstract: Metabolites produced by the human microbiota can function as agonists for a wide range of G protein-coupled receptors, making metabolome screening a useful tool to both de-orphanize human GPCRs and identify metabolic exchanges between commensal microbes in the gut with effects on host physiology.
      Citation: Cell (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.036
  • Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate
    • Authors: Cristhian Cadena; Sadeem Ahmad, Audrey Xavier, Joschka Willemsen, Sehoon Park, Ji Woo Park, Seong-Wook Oh, Takashi Fujita, Fajian Hou, Marco Binder, Sun Hur
      Abstract: The E3 ligase RIPLET activates RIG-I via dual ubiquitin-dependent and -independent mechanisms that together work to discriminate the length of dsRNA sensed by RIG-I.
      Citation: Cell (2019)
      PubDate: 2019-04-18
      DOI: 10.1016/j.cell.2019.03.017
  • Human Pluripotency Is Initiated and Preserved by a Unique Subset of
           Founder Cells
    • Authors: Mio Nakanishi; Ryan R. Mitchell, Yannick D. Benoit, Luca Orlando, Jennifer C. Reid, Kenichi Shimada, Kathryn C. Davidson, Zoya Shapovalova, Tony J. Collins, Andras Nagy, Mickie Bhatia
      Abstract: Human pluripotent founder cells within stem cell cultures share hallmark properties with primitive endoderm and reside exclusively at colony boundaries.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.013
  • Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed
           Sculpted Light Microscopy
    • Authors: Siegfried Weisenburger; Frank Tejera, Jeffrey Demas, Brandon Chen, Jason Manley, Fraser T. Sparks, Francisca Martínez Traub, Tanya Daigle, Hongkui Zeng, Attila Losonczy, Alipasha Vaziri
      Abstract: A new volumetric calcium imaging method called hybrid multiplexed sculpted light microscopy (HyMS) opens up the window to record neuronal activity of more than 10,000 neurons over the entire cortical depth and within the hippocampus of awake and behaving mice.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.011
  • Promoter-Intrinsic and Local Chromatin Features Determine Gene Repression
           in LADs
    • Authors: Christ Leemans; Marloes C.H. van der Zwalm, Laura Brueckner, Federico Comoglio, Tom van Schaik, Ludo Pagie, Joris van Arensbergen, Bas van Steensel
      Abstract: A systematic look at mammalian promoters reveals that lamina-associated domains inherently repress transcription and also gives the first clues as to what dictates whether a gene can escape such silencing.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.009
  • Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in
           Drosophila Embryos
    • Authors: Victoria E. Deneke; Alberto Puliafito, Daniel Krueger, Avaneesh V. Narla, Alessandro De Simone, Luca Primo, Massimo Vergassola, Stefano De Renzis, Stefano Di Talia
      Abstract: Synchronization of the cell cycle in syncytial Drosophila embryos is controlled by a self-organized mechanism that drives accurate nuclear positioning by integrating localized cell-cycle oscillations, actomyosin cortical contractility, and cytoplasmic flows.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.007
  • A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast
    • Authors: Johanna Wagner; Maria Anna Rapsomaniki, Stéphane Chevrier, Tobias Anzeneder, Claus Langwieder, August Dykgers, Martin Rees, Annette Ramaswamy, Simone Muenst, Savas Deniz Soysal, Andrea Jacobs, Jonas Windhager, Karina Silina, Maries van den Broek, Konstantin Johannes Dedes, Maria Rodríguez Martínez, Walter Paul Weber, Bernd Bodenmiller
      Abstract: A single-cell atlas of cancer and immune cells reveals distinct tumor ecosystems across breast cancer patients, informing prognosis and, potentially, therapy selection.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.005
  • A Compendium of Mutational Signatures of Environmental Agents
    • Authors: Jill E. Kucab; Xueqing Zou, Sandro Morganella, Madeleine Joel, A. Scott Nanda, Eszter Nagy, Celine Gomez, Andrea Degasperi, Rebecca Harris, Stephen P. Jackson, Volker M. Arlt, David H. Phillips, Serena Nik-Zainal
      Abstract: The effects of a range of environmental mutagens in terms of the kinds of mutations they induce and how these are repaired by the cell is presented in the form of a resource.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.03.001
  • Primate Amygdala Neurons Simulate Decision Processes of Social Partners
    • Authors: Fabian Grabenhorst; Raymundo Báez-Mendoza, Wilfried Genest, Gustavo Deco, Wolfram Schultz
      Abstract: When monkeys observe and learn from each other’s choices, neurons in the amygdala spontaneously encode decision computations to simulate the social partner’s choices.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.02.042
  • Multiple Deeply Divergent Denisovan Ancestries in Papuans
    • Authors: Guy S. Jacobs; Georgi Hudjashov, Lauri Saag, Pradiptajati Kusuma, Chelzie C. Darusallam, Daniel J. Lawson, Mayukh Mondal, Luca Pagani, François-Xavier Ricaut, Mark Stoneking, Mait Metspalu, Herawati Sudoyo, J. Stephen Lansing, Murray P. Cox
      Abstract: Genome sequences from Island Southeast Asia suggest two independent Denisovan lineages, distinct from the Altai Denisovan, that have contributed to modern Papuan genomes, with one group potentially present east of the Wallace Line and thus capable of crossing geographical barriers.
      Citation: Cell (2019)
      PubDate: 2019-04-10
      DOI: 10.1016/j.cell.2019.02.035
  • Profiling of Pluripotency Factors in Single Cells and Early Embryos
    • Authors: Sarah J. Hainer; Ana Bošković, Kurtis N. McCannell, Oliver J. Rando, Thomas G. Fazzio
      Abstract: A modified CUT&RUN method makes it possible to map chromatin proteins in very low cell numbers, including profiling of several transcription factors in single cells, enabling interrogation of rare cell populations of particular importance in development or disease.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.014
  • A Jasmonate Signaling Network Activates Root Stem Cells and Promotes
    • Authors: Wenkun Zhou; Jose L. Lozano-Torres, Ikram Blilou, Xiaoyue Zhang, Qingzhe Zhai, Geert Smant, Chuanyou Li, Ben Scheres
      Abstract: Stem cell activation and regeneration after tissue damage in Arabidopsis roots is mediated by a jasmonate signaling network.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.006
  • Genome-wide de novo L1 Retrotransposition Connects Endonuclease Activity
           with Replication
    • Authors: Diane A. Flasch; Ángela Macia, Laura Sánchez, Mats Ljungman, Sara R. Heras, José L. García-Pérez, Thomas E. Wilson, John V. Moran
      Abstract: The examination of de novo engineered L1 retrotransposition events in cultured human cells reveals that L1 endonuclease activity and DNA replication dictate L1 insertion preferences and promote its widespread integration throughout the human genome.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.050
  • Once and Only Once
    • Authors: Susan Gasser
      First page: 495
      Abstract: The 2019 Gairdner Prize will be given to John F.X. Diffley and Bruce Stillman for their groundbreaking work on the mechanisms and control of the initiation of eukaryotic DNA replication. No two people have contributed more extensively, or over a longer period of time, to enlighten us on how our genomes replicate themselves once and only once per cell cycle.
      Citation: Cell ()
      PubDate: 2019-04-02
      DOI: 10.1016/j.cell.2019.03.034
  • Integrins and Their Role in Immune Cell Adhesion
    • Authors: Michael L. Dustin
      First page: 499
      Abstract: One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer’s discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.
      Citation: Cell (2019)
      PubDate: 2019-04-02
      DOI: 10.1016/j.cell.2019.03.038
  • Reflections on My Life with Taxol
    • Authors: Susan Band Horwitz
      First page: 502
      Abstract: When I was finishing up my graduate studies at Brandeis University, my plan was to pursue the field of enzyme kinetics after I received my PhD in biochemistry. But after giving birth to twins 5 days after defending my thesis, I decided my plan required a short-term adjustment. My thesis advisor, professor Nathan O. Kaplan, helped me to find a position that would accommodate a flexible schedule while my boys were young. As a result, I began conducting research in the Department of Pharmacology at Tufts University Medical School, with the expectation that I would move back into my intended field in a few years.
      Citation: Cell ()
      PubDate: 2019-04-02
      DOI: 10.1016/j.cell.2019.03.031
  • Keep Your Eyes on the Prize
    • Authors: Ronald D. Vale
      First page: 506
      Abstract: It is a great honor for me to receive the prestigious Gairdner Award for Biomedical Research. The title of this essay might imply that it will contain advice on how to win such a major scientific prize. However, my intention is quite different. More in keeping with the famous civil rights song of the same name, my hope is to articulate a bigger picture view of what matters in the long run. Why do we do science' What is fulfilling about a career in science' Is an international prize the pinnacle of success, or are there more important outcomes'
      Citation: Cell (2019)
      PubDate: 2019-04-02
      DOI: 10.1016/j.cell.2019.03.039
  • Evolving as a Scientist and a Mentor
    • First page: 510
      Abstract: Connie Eaves sets high standards for herself, her science, and her colleagues, which has fueled a stellar career that counts as successes insights into basic stem cell biology, important discoveries in leukemia and breast cancer, and a cohort of trainees that she considers family. Cell editor Lara Szewczak caught up with Connie, the recipient of the 2019 Canada Gairdner Wightman Award, to discuss her dual passions for stem cell biology and mentoring talented young scientists. Annotated excerpts from this conversation are presented below.
      Citation: Cell (2019)
      PubDate: 2019-04-02
      DOI: 10.1016/j.cell.2019.03.033
  • Resident Macrophages Cloak Tissue Microlesions to Prevent
           Neutrophil-Driven Inflammatory Damage
    • Authors: Stefan Uderhardt; Andrew J. Martins, John S. Tsang, Tim Lämmermann, Ronald N. Germain
      First page: 541
      Abstract: In order to maintain homeostasis, tissue-resident macrophages surround and hide very small tissue lesions to prevent excess inflammation driven by neutrophils.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.028
  • Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T
           Cell Immunity
    • Authors: Mikhail Binnewies; Adriana M. Mujal, Joshua L. Pollack, Alexis J. Combes, Emily A. Hardison, Kevin C. Barry, Jessica Tsui, Megan K. Ruhland, Kelly Kersten, Marwan A. Abushawish, Marko Spasic, Jonathan P. Giurintano, Vincent Chan, Adil I. Daud, Patrick Ha, Chun J. Ye, Edward W. Roberts, Matthew F. Krummel
      First page: 556
      Abstract: A subtype of conventional dendritic cells, cDC2, are able to prime CD4+ T cells for antitumor functions and the presence of cDC2 in human cancer samples may serve as a predictive biomarker for survival and response to immune checkpoint blockade.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.005
  • A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma
    • Authors: Nikki K. Lytle; L. Paige Ferguson, Nirakar Rajbhandari, Kathryn Gilroy, Raymond G. Fox, Anagha Deshpande, Christian M. Schürch, Michael Hamilton, Neil Robertson, Wei Lin, Pawan Noel, Martin Wartenberg, Inti Zlobec, Micha Eichmann, José A. Galván, Eva Karamitopoulou, Tami Gilderman, Lourdes Adriana Esparza, Yutaka Shima, Philipp Spahn, Randall French, Nathan E. Lewis, Kathleen M. Fisch, Roman Sasik, Sara Brin Rosenthal, Marcie Kritzik, Daniel Von Hoff, Haiyong Han, Trey Ideker, Aniruddha J. Deshpande, Andrew M. Lowy, Peter D. Adams, Tannishtha Reya
      First page: 572
      Abstract: Pancreatic cancer stem cells co-opt immuno-regulatory pathways, a vulnerability that could be exploited therapeutically by agents currently in trials for autoimmune diseases.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.010
  • Somatic Mutations Increase Hepatic Clonal Fitness and Regeneration in
           Chronic Liver Disease
    • Authors: Min Zhu; Tianshi Lu, Yuemeng Jia, Xin Luo, Purva Gopal, Lin Li, Mobolaji Odewole, Veronica Renteria, Amit G. Singal, Younghoon Jang, Kai Ge, Sam C. Wang, Mahsa Sorouri, Justin R. Parekh, Malcolm P. MacConmara, Adam C. Yopp, Tao Wang, Hao Zhu
      First page: 608
      Abstract: Deep sequencing reveals the mutational landscape of human cirrhosis and in vivo CRISPR screening identifies functional roles for recurrently mutated genes in hepatocyte fitness and liver regeneration.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.026
  • Antisense lncRNA Transcription Mediates DNA Demethylation to Drive
           Stochastic Protocadherin α Promoter Choice
    • Authors: Daniele Canzio; Chiamaka L. Nwakeze, Adan Horta, Sandy M. Rajkumar, Eliot L. Coffey, Erin E. Duffy, Rachel Duffié, Kevin Monahan, Sean O’Keeffe, Matthew D. Simon, Stavros Lomvardas, Tom Maniatis
      First page: 639
      Abstract: Coupling transcription of a long noncoding RNA to DNA demethylation ensures stochastic promoter choice for clustered Protocadherin α genes, which is essential for the establishment of a neuronal surface identity code involved in circuit assembly.
      Citation: Cell ()
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.008
  • A Common Embryonic Origin of Stem Cells Drives Developmental and Adult
    • Authors: Daniel A. Berg; Yijing Su, Dennisse Jimenez-Cyrus, Aneek Patel, Nancy Huang, David Morizet, Stephanie Lee, Reeti Shah, Francisca Rojas Ringeling, Rajan Jain, Jonathan A. Epstein, Qing-Feng Wu, Stefan Canzar, Guo-Li Ming, Hongjun Song, Allison M. Bond
      First page: 654
      Abstract: Adult hippocampal neurogenesis is a continuous process from development with shared embryonic dentate neural progenitors in mice.
      Citation: Cell (2019)
      PubDate: 2019-03-28
      DOI: 10.1016/j.cell.2019.02.010
  • Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor
    • Authors: Mark J. Wagner; Tony Hyun Kim, Jonathan Kadmon, Nghia D. Nguyen, Surya Ganguli, Mark J. Schnitzer, Liqun Luo
      First page: 669
      Abstract: Simultaneous recordings of ensembles of individual neurons in the neocortex and cerebellum provide a view of how these two brain regions learn together.
      Citation: Cell (2019)
      PubDate: 2019-03-28
      DOI: 10.1016/j.cell.2019.02.019
  • Pathogenic E. coli Extracts Nutrients from Infected Host Cells
           Utilizing Injectisome Components
    • Authors: Ritesh Ranjan Pal; Amit K. Baidya, Gideon Mamou, Saurabh Bhattacharya, Yaakov Socol, Simi Kobi, Naama Katsowich, Sigal Ben-Yehuda, Ilan Rosenshine
      First page: 683
      Abstract: Host-attached enteropathogenic E. coli can extract nutrients from mammalian host cells via the CORE protein complex, a platform for membranous nanotube structure formation.
      Citation: Cell (2019)
      PubDate: 2019-03-28
      DOI: 10.1016/j.cell.2019.02.022
  • Yeast Ataxin-2 Forms an Intracellular Condensate Required for the
           Inhibition of TORC1 Signaling during Respiratory Growth
    • Authors: Yu-San Yang; Masato Kato, Xi Wu, Athanasios Litsios, Benjamin M. Sutter, Yun Wang, Chien-Hsiang Hsu, N. Ezgi Wood, Andrew Lemoff, Hamid Mirzaei, Matthias Heinemann, Benjamin P. Tu
      First page: 697
      Abstract: Unpacking the role of yeast ataxin-2 reveals that it preserves mitochondrial homeostasis, undergoing a condition-sensitive phase transition to modulate TORC1 function.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.02.043
  • Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via
           Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain
    • Authors: Masato Kato; Yu-San Yang, Benjamin M. Sutter, Yun Wang, Steven L. McKnight, Benjamin P. Tu
      First page: 711
      Abstract: Many proteins that are able to undergo phase transitions contain repeats rich in hydrophobic residues. By contrast, yeast ataxin-2 condensates rely on an abundance of methionines, providing a means for redox-sensitive regulation of its material properties.
      Citation: Cell (2019)
      PubDate: 2019-04-11
      DOI: 10.1016/j.cell.2019.02.044
  • Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene
    • Authors: Melissa L. Hancock; Rebecca C. Meyer, Meeta Mistry, Radhika S. Khetani, Alexandre Wagschal, Taehwan Shin, Shannan J. Ho Sui, Anders M. Näär, John G. Flanagan
      First page: 722
      Abstract: Insulin receptor translocates from the cell surface to the nucleus, where it associates with transcriptional machinery at promoters, and regulates genes linked to insulin functions.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.030
  • The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved
           Electrostatic Interface Essential for Cellular Proteostasis
    • Authors: Daniel Gestaut; Soung Hun Roh, Boxue Ma, Grigore Pintilie, Lukasz A. Joachimiak, Alexander Leitner, Thomas Walzthoeni, Ruedi Aebersold, Wah Chiu, Judith Frydman
      First page: 751
      Abstract: Direct interactions between two chaperonins allow them to feed folding substrates bi-directionally between active sites, preventing aggregation and promoting proteostasis.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.03.012
  • ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and
    • Authors: Richard S. Marshall; Zhihua Hua, Sujina Mali, Fionn McLoughlin, Richard D. Vierstra
      First page: 766
      Abstract: Across organisms, the key autophagy protein ATG8/LC3 binds a group of proteins on a site distinct from its classical interacting region, raising the possibility of dual binding interactions and identifying an array of previously unknown selective autophagic adaptors and receptors, including some involved in human disease.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.009
  • Engineering a Model Cell for Rational Tuning of GPCR Signaling
    • Authors: William M. Shaw; Hitoshi Yamauchi, Jack Mead, Glen-Oliver F. Gowers, David J. Bell, David Öling, Niklas Larsson, Mark Wigglesworth, Graham Ladds, Tom Ellis
      First page: 782
      Abstract: Engineering GPCR-based signaling in yeast allows exploration of signaling properties and creation of synthetic responses to a range of ligands.
      Citation: Cell (2019)
      PubDate: 2019-04-04
      DOI: 10.1016/j.cell.2019.02.023
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