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Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1306  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3206 journals]
  • What Makes a Discovery Successful' The Story of Linda Buck and the
           Olfactory Receptors
    • Authors: Ann-Sophie Barwich
      Pages: 749 - 753
      Abstract: In 1991, Buck and Axel published a landmark study in Cell for work that was awarded the 2004 Nobel Prize. The identification of the olfactory receptors as the largest family of GPCRs catapulted olfaction into mainstream neurobiology. This BenchMark revisits Buck’s experimental innovation and its surprising success at the time.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.04.040
      Issue No: Vol. 181, No. 4 (2020)
       
  • Race Matters
    • Authors: David J. Asai
      Pages: 754 - 757
      Abstract: Despite their initial high interest in science, students who belong to excluded racial and ethnic groups leave science at unacceptably high rates. “Fixing the student” approaches are not sufficient at stemming the loss. It is time to change the culture of science by putting inclusive diversity at the center.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.03.044
      Issue No: Vol. 181, No. 4 (2020)
       
  • Writing to the Mind’s Eye of the Blind
    • Authors: Pieter R. Roelfsema
      Pages: 758 - 759
      Abstract: The implantation of electrodes on the visual cortex of blind individuals could lead to the restoration of a rudimentary form of sight. In this issue of Cell, Beauchamp et al. use electrical stimulation of the visual cortex to create visual perception of shapes.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.03.014
      Issue No: Vol. 181, No. 4 (2020)
       
  • Feeling Stressed' Piezo1-Mediated Loss of Heterochromatin Buys Time
           for Long-Term Adaptation
    • Authors: Jan Lammerding; Chieh-Ren Hsia
      Pages: 760 - 762
      Abstract: Skin and other epithelial cell layers are frequently subjected to extensive deformations, yet sustain such mechanical stress without damage. In this issue of Cell, Nava and colleagues show that stretch induces rapid loss of heterochromatin that leads to transient softening of the nucleus, which, together with long-term cytoskeletal and supracellular rearrangements, protects nuclei from DNA damage.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.04.041
      Issue No: Vol. 181, No. 4 (2020)
       
  • Restoring the Sense of Touch Using a Sensorimotor Demultiplexing Neural
           Interface
    • Authors: Patrick D. Ganzer; Samuel C. Colachis, Michael A. Schwemmer, David A. Friedenberg, Collin F. Dunlap, Carly E. Swiftney, Adam F. Jacobowitz, Doug J. Weber, Marcia A. Bockbrader, Gaurav Sharma
      Pages: 763 - 773.e12
      Abstract: Sensation is restored to the hand of a participant with quadriplegia by a brain-computer interface that transforms residual, subperceptual touch signals into conscious perception.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-23
      DOI: 10.1016/j.cell.2020.03.054
      Issue No: Vol. 181, No. 4 (2020)
       
  • Dynamic Stimulation of Visual Cortex Produces Form Vision in Sighted and
           Blind Humans
    • Authors: Michael S. Beauchamp; Denise Oswalt, Ping Sun, Brett L. Foster, John F. Magnotti, Soroush Niketeghad, Nader Pouratian, William H. Bosking, Daniel Yoshor
      Pages: 774 - 783.e5
      Abstract: Dynamic stimulation of visual cortex allows both sighted and blind subjects to recognize a variety of letter shapes without training and with high accuracy.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.04.033
      Issue No: Vol. 181, No. 4 (2020)
       
  • Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous
           System Edema
    • Authors: Philip Kitchen; Mootaz M. Salman, Andrea M. Halsey, Charlotte Clarke-Bland, Justin A. MacDonald, Hiroaki Ishida, Hans J. Vogel, Sharif Almutiri, Ann Logan, Stefan Kreida, Tamim Al-Jubair, Julie Winkel Missel, Pontus Gourdon, Susanna Törnroth-Horsefield, Matthew T. Conner, Zubair Ahmed, Alex C. Conner, Roslyn M. Bill
      Pages: 784 - 799.e19
      Abstract: Modulating the subcellular localization of the water channel protein AQP4 may be a therapeutic option for treatment of brain and spinal cord edemas.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-14
      DOI: 10.1016/j.cell.2020.03.037
      Issue No: Vol. 181, No. 4 (2020)
       
  • Heterochromatin-Driven Nuclear Softening Protects the Genome against
           Mechanical Stress-Induced Damage
    • Authors: Michele M. Nava; Yekaterina A. Miroshnikova, Leah C. Biggs, Daniel B. Whitefield, Franziska Metge, Jorge Boucas, Helena Vihinen, Eija Jokitalo, Xinping Li, Juan Manuel García Arcos, Bernd Hoffmann, Rudolf Merkel, Carien M. Niessen, Kris Noel Dahl, Sara A. Wickström
      Pages: 800 - 817.e22
      Abstract: When tissues are stretched, cells respond via two distinct mechanosensory mechanisms to protect the genome from damage and maintain tissue homeostasis. First, rapid heterochromatin-mediated mechanosensing, independent of known cellular mechanosensors, drives calcium-dependent nuclear softening. If the mechanical stress persists, a second, tissue-level reorganization occurs, mediated by cell-cell contacts to redistribute mechanical energy to prevent force transmission to the nucleus.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-16
      DOI: 10.1016/j.cell.2020.03.052
      Issue No: Vol. 181, No. 4 (2020)
       
  • Condensation of Ded1p Promotes a Translational Switch from Housekeeping to
           Stress Protein Production
    • Authors: Christiane Iserman; Christine Desroches Altamirano, Ceciel Jegers, Ulrike Friedrich, Taraneh Zarin, Anatol W. Fritsch, Matthäus Mittasch, Antonio Domingues, Lena Hersemann, Marcus Jahnel, Doris Richter, Ulf-Peter Guenther, Matthias W. Hentze, Alan M. Moses, Anthony A. Hyman, Günter Kramer, Moritz Kreysing, Titus M. Franzmann, Simon Alberti
      Pages: 818 - 831.e19
      Abstract: Heat-induced phase separation of a helicase promotes a switch in translation from housekeeping transcripts to stress-response transcripts.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-30
      DOI: 10.1016/j.cell.2020.04.009
      Issue No: Vol. 181, No. 4 (2020)
       
  • Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal
           Adenocarcinoma
    • Authors: Katherine Minjee Chung; Jaffarguriqbal Singh, Lauren Lawres, Kimberly Judith Dorans, Cathy Garcia, Daniel B. Burkhardt, Rebecca Robbins, Arjun Bhutkar, Rebecca Cardone, Xiaojian Zhao, Ana Babic, Sara A. Vayrynen, Andressa Dias Costa, Jonathan A. Nowak, Daniel T. Chang, Richard F. Dunne, Aram F. Hezel, Albert C. Koong, Joshua J. Wilhelm, Melena D. Bellin, Vibe Nylander, Anna L. Gloyn, Mark I. McCarthy, Richard G. Kibbey, Smita Krishnaswamy, Brian M. Wolpin, Tyler Jacks, Charles S. Fuchs, Mandar Deepak Muzumdar
      Pages: 832 - 847.e18
      Abstract: Obesity is an intrinsic driver of PDAC in mice, leading to a remodeling of beta cells to increase CCK secretion and playing a role early in pancreatic cancer development that can be intercepted by weight loss.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-17
      DOI: 10.1016/j.cell.2020.03.062
      Issue No: Vol. 181, No. 4 (2020)
       
  • Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and
           Fibrosis
    • Authors: Wei Rao; Shan Wang, Marcin Duleba, Suchan Niroula, Kristina Goller, Jingzhong Xie, Rajasekaran Mahalingam, Rahul Neupane, Audrey-Ann Liew, Matthew Vincent, Kenichi Okuda, Wanda K. O’Neal, Richard C. Boucher, Burton F. Dickey, Michael E. Wechsler, Omar Ibrahim, John F. Engelhardt, Tinne C.J. Mertens, Wei Wang, Soma S.K. Jyothula, Christopher P. Crum, Harry Karmouty-Quintana, Kalpaj R. Parekh, Mark L. Metersky, Frank D. McKeon, Wa Xian
      Pages: 848 - 864.e18
      Abstract: The hallmark features of COPD (inflammation, fibrosis, and mucus hypersecretion) are driven by distinct pathogenic progenitors which pre-exist as minor populations in healthy lungs but dominate in the disease state relative to normal lung stem cells.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-15
      DOI: 10.1016/j.cell.2020.03.047
      Issue No: Vol. 181, No. 4 (2020)
       
  • Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and
           Influenza
    • Authors: Timothy R. Abbott; Girija Dhamdhere, Yanxia Liu, Xueqiu Lin, Laine Goudy, Leiping Zeng, Augustine Chemparathy, Stephen Chmura, Nicholas S. Heaton, Robert Debs, Tara Pande, Drew Endy, Marie F. La Russa, David B. Lewis, Lei S. Qi
      Pages: 865 - 876.e12
      Abstract: A CRISPR-based strategy is developed to target conserved sequences across coronaviruses and other pathogenic viruses.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-29
      DOI: 10.1016/j.cell.2020.04.020
      Issue No: Vol. 181, No. 4 (2020)
       
  • A Structure-Based Model for the Complete Transcription Cycle of Influenza
           Polymerase
    • Authors: Joanna M. Wandzik; Tomas Kouba, Manikandan Karuppasamy, Alexander Pflug, Petra Drncova, Jan Provaznik, Nayara Azevedo, Stephen Cusack
      Pages: 877 - 893.e21
      Abstract: Influenza polymerase transcribes the negative sense viral RNA genome into mRNA in the nucleus of infected cells. This work by Cusack and colleagues reports high-resolution cryo-EM structures of the polymerase at various stages of transcription providing a molecular basis for the complete transcription cycle, which should enable improved inhibitor design.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-17
      DOI: 10.1016/j.cell.2020.03.061
      Issue No: Vol. 181, No. 4 (2020)
       
  • Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
    • Authors: Qihui Wang; Yanfang Zhang, Lili Wu, Sheng Niu, Chunli Song, Zengyuan Zhang, Guangwen Lu, Chengpeng Qiao, Yu Hu, Kwok-Yung Yuen, Qisheng Wang, Huan Zhou, Jinghua Yan, Jianxun Qi
      Pages: 894 - 904.e9
      Abstract: The crystal structure of the C-terminal domain of the SARS-CoV-2 spike protein in complex with human ACE2 reveals insights into the mechanisms of binding of this virus and its differences from SARS.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-09
      DOI: 10.1016/j.cell.2020.03.045
      Issue No: Vol. 181, No. 4 (2020)
       
  • Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using
           Clinical-Grade Soluble Human ACE2
    • Authors: Vanessa Monteil; Hyesoo Kwon, Patricia Prado, Astrid Hagelkrüys, Reiner A. Wimmer, Martin Stahl, Alexandra Leopoldi, Elena Garreta, Carmen Hurtado del Pozo, Felipe Prosper, Juan Pablo Romero, Gerald Wirnsberger, Haibo Zhang, Arthur S. Slutsky, Ryan Conder, Nuria Montserrat, Ali Mirazimi, Josef M. Penninger
      Pages: 905 - 913.e7
      Abstract: Clinical-grade recombinant human ACE2 can reduce SARS-CoV-2 infection in cells and in multiple human organoid models.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-24
      DOI: 10.1016/j.cell.2020.04.004
      Issue No: Vol. 181, No. 4 (2020)
       
  • The Architecture of SARS-CoV-2 Transcriptome
    • Authors: Dongwan Kim; Joo-Yeon Lee, Jeong-Sun Yang, Jun Won Kim, V. Narry Kim, Hyeshik Chang
      Pages: 914 - 921.e10
      Abstract: The SARS-CoV-2 transcriptome and epitranscriptome reveal a complex array of canonical and non-canonical viral transcripts with RNA modifications.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-23
      DOI: 10.1016/j.cell.2020.04.011
      Issue No: Vol. 181, No. 4 (2020)
       
  • MorphoSeq: Full Single-Cell Transcriptome Dynamics Up to Gastrulation in a
           Chordate
    • Authors: Hanna L. Sladitschek; Ulla-Maj Fiuza, Dinko Pavlinic, Vladimir Benes, Lars Hufnagel, Pierre A. Neveu
      Pages: 922 - 935.e21
      Abstract: The complete gene expression history and physical position of every single cell at every cell division in an embryo up to gastrulation is reconstructed using a combination of single-cell transcriptomics and light sheet imaging.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-20
      DOI: 10.1016/j.cell.2020.03.055
      Issue No: Vol. 181, No. 4 (2020)
       
  • The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas
    • Authors: Quanxin Wang; Song-Lin Ding, Yang Li, Josh Royall, David Feng, Phil Lesnar, Nile Graddis, Maitham Naeemi, Benjamin Facer, Anh Ho, Tim Dolbeare, Brandon Blanchard, Nick Dee, Wayne Wakeman, Karla E. Hirokawa, Aaron Szafer, Susan M. Sunkin, Seung Wook Oh, Amy Bernard, John W. Phillips, Michael Hawrylycz, Christof Koch, Hongkui Zeng, Julie A. Harris, Lydia Ng
      Pages: 936 - 953.e20
      Abstract: The Allen Mouse Brain CCF is an openly accessible, cellular level resolution 3D reference atlas for analysis, visualization, and integration of multimodal and multiscale datasets.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-05-07
      DOI: 10.1016/j.cell.2020.04.007
      Issue No: Vol. 181, No. 4 (2020)
       
  • SnapShot: COVID-19
    • Authors: Blake Oberfeld; Aditya Achanta, Kendall Carpenter, Pamela Chen, Nicole M. Gilette, Pinky Langat, Jordan Taylor Said, Abigail E. Schiff, Allen S. Zhou, Amy K. Barczak, Shiv Pillai
      Pages: 954 - 954.e1
      Abstract: Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and vaccines are in development. To view this SnapShot, open or download the PDF.
      Citation: Cell 181, 4 (2020)
      PubDate: 2020-04-29
      DOI: 10.1016/j.cell.2020.04.013
      Issue No: Vol. 181, No. 4 (2020)
       
 
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