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Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1170  
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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3183 journals]
  • Just Solid or Liquid Enough
    • Authors: Lara Szewczak
      First page: 763
      Abstract: Ice cools a drink, water carves a canyon, steam powers a locomotive. Three atoms take on three different states, and each state enables processes the others cannot. But ice brings down power lines, water floods towns, steam scalds skin. The context for these states matters, and there can be consequences if the appropriate state is perturbed or dysregulated. Now more than ever, we understand that physical states dictate biological function, and while material states in biology are certainly more complex and less discrete than those for H2O, recent papers have highlighted, at the subcellular and tissue levels, the importance of understanding those states and the conditions in which they occur.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.027
      Issue No: Vol. 178, No. 4 (2019)
  • Align to Define: Ecologically Meaningful Populations from Genomes
    • Authors: Sergey Stolyar; Christopher J. Marx
      Pages: 767 - 768
      Abstract: Microbes in the same community but with distinct niches can have unique long stretches of perfect sequence identity due to recent genetic exchange. Arevalo et al. (2019) use this as a starting point for defining ecologically-relevant populations within a community and to identify the genes that appear to be driving divergence between populations.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.026
      Issue No: Vol. 178, No. 4 (2019)
  • A Light Touch on Sociability
    • Authors: Nuria Domínguez-Iturza; Claudia Bagni
      Pages: 769 - 771
      Abstract: Autism spectrum disorder (ASD) is prevalent, complex, and heterogeneous, and currently there is no cure. Identifying shared mechanisms across the ASD spectrum is of utmost importance for therapeutic intervention. Orefice et al. show that tackling the GABAA receptor pathway in the peripheral somatosensory system in various ASD mouse models rescues core ASD-like phenotypes.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.022
      Issue No: Vol. 178, No. 4 (2019)
  • Sensory Neurons Drive Anticipatory Immunity
    • Authors: Anna M. Trier; Brian S. Kim
      Pages: 771 - 773
      Abstract: Sensory neurons have recently emerged as critical mediators of immunity. Cohen et al. (2019) demonstrate that peripheral neurons utilize reflex arcs in order to rapidly condition the immune response in skin adjacent to the site of infection. This nerve reflex arc generates anticipatory immunity for more effective elimination of the pathogen if later exposed.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.012
      Issue No: Vol. 178, No. 4 (2019)
  • Slow Down to Catch Up
    • Authors: Sujatha Jagannathan; Srinivas Ramachandran, Olivia S. Rissland
      Pages: 774 - 776
      Abstract: In this issue of Cell, Cassidy et al. (2019) show that, in Drosophila melanogaster, developmental abnormalities resulting from loss of repressors such as microRNAs can be suppressed by slow metabolism. They additionally provide insight into the underlying mechanism that connects metabolic state with developmental outcomes.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.025
      Issue No: Vol. 178, No. 4 (2019)
  • Voltage Sensing Comes to Rest
    • Authors: Izhar Karbat; Eitan Reuveny
      Pages: 776 - 778
      Abstract: Voltage sensing by ion channels is the key event enabling the generation and propagation of electrical activity in excitable cells. In this issue of Cell, Wisedchaisri et al. provide a structural view of a voltage-gated sodium channel in its resting closed conformation.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.013
      Issue No: Vol. 178, No. 4 (2019)
  • Benchmarking Metagenomics Tools for Taxonomic Classification
    • Authors: Simon H. Ye; Katherine J. Siddle, Daniel J. Park, Pardis C. Sabeti
      Pages: 779 - 794
      Abstract: Metagenomic sequencing is revolutionizing the detection and characterization of microbial species, and a wide variety of software tools are available to perform taxonomic classification of these data. The fast pace of development of these tools and the complexity of metagenomic data make it important that researchers are able to benchmark their performance. Here, we review current approaches for metagenomic analysis and evaluate the performance of 20 metagenomic classifiers using simulated and experimental datasets. We describe the key metrics used to assess performance, offer a framework for the comparison of additional classifiers, and discuss the future of metagenomic data analysis.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.010
      Issue No: Vol. 178, No. 4 (2019)
  • Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer
    • Authors: Erick Riquelme; Yu Zhang, Liangliang Zhang, Maria Montiel, Michelle Zoltan, Wenli Dong, Pompeyo Quesada, Ismet Sahin, Vidhi Chandra, Anthony San Lucas, Paul Scheet, Hanwen Xu, Samir M. Hanash, Lei Feng, Jared K. Burks, Kim-Anh Do, Christine B. Peterson, Deborah Nejman, Ching-Wei D. Tzeng, Michael P. Kim, Cynthia L. Sears, Nadim Ajami, Joseph Petrosino, Laura D. Wood, Anirban Maitra, Ravid Straussman, Matthew Katz, James Robert White, Robert Jenq, Jennifer Wargo, Florencia McAllister
      Pages: 795 - 806.e12
      Abstract: The distinct tumor microbiome from pancreatic cancer long-term survivors can be used to predict PDAC survival in humans, and transfer of long-term survivor gut microbiomes can alter the tumor microbiome and tumor growth in mouse models.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.008
      Issue No: Vol. 178, No. 4 (2019)
  • The Oncogenic Action of NRF2 Depends on De-glycation by
    • Authors: Viraj R. Sanghvi; Josef Leibold, Marco Mina, Prathibha Mohan, Marjan Berishaj, Zhuoning Li, Matthew M. Miele, Nathalie Lailler, Chunying Zhao, Elisa de Stanchina, Agnes Viale, Leila Akkari, Scott W. Lowe, Giovanni Ciriello, Ronald C. Hendrickson, Hans-Guido Wendel
      Pages: 807 - 819.e21
      Abstract: Fructosamine-3-kinase promotes hepatocellular carcinoma by mediating deglycation of NRF2, a protein modification process previously understudied for cellular proteins.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.031
      Issue No: Vol. 178, No. 4 (2019)
  • A Reverse Ecology Approach Based on a Biological Definition of Microbial
    • Authors: Philip Arevalo; David VanInsberghe, Joseph Elsherbini, Jeff Gore, Martin F. Polz
      Pages: 820 - 834.e14
      Abstract: Defining bacterial populations by examining recent horizontal gene transfer events illuminates ecologically meaningful interspecies relationships in the environment and in the human microbiome.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.06.033
      Issue No: Vol. 178, No. 4 (2019)
  • Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks
    • Authors: Elizabeth K. Ruzzo; Laura Pérez-Cano, Jae-Yoon Jung, Lee-kai Wang, Dorna Kashef-Haghighi, Chris Hartl, Chanpreet Singh, Jin Xu, Jackson N. Hoekstra, Olivia Leventhal, Virpi M. Leppä, Michael J. Gandal, Kelley Paskov, Nate Stockham, Damon Polioudakis, Jennifer K. Lowe, David A. Prober, Daniel H. Geschwind, Dennis P. Wall
      Pages: 850 - 866.e26
      Abstract: Whole-genome sequencing from families with multiple ASD-affected children allows identification of rare inherited variants associated with disease and definition of a syndromic form of disease caused by mutations in NR3C2.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.015
      Issue No: Vol. 178, No. 4 (2019)
  • Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related
           Phenotypes in ASD Models
    • Authors: Lauren L. Orefice; Jacqueline R. Mosko, Danielle T. Morency, Michael F. Wells, Aniqa Tasnim, Shawn M. Mozeika, Mengchen Ye, Anda M. Chirila, Alan J. Emanuel, Genelle Rankin, Ryann M. Fame, Maria K. Lehtinen, Guoping Feng, David D. Ginty
      Pages: 867 - 886.e24
      Abstract: Treatment with a peripherally restricted GABAA receptor agonist in multiple distinct autism spectrum disorder mouse models reveals a potential therapeutic strategy for select ASD-related behaviors.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.024
      Issue No: Vol. 178, No. 4 (2019)
  • CAG Repeat Not Polyglutamine Length Determines Timing of
           Huntington’s Disease Onset
    • Authors: Genetic Modifiers of Huntington’s Disease (GeM-HD) Consortium
      Pages: 887 - 900.e14
      Abstract: The onset of Huntington’s disease is shown to be dependent on the size of the uninterrupted CAG repeat sequence, not polyglutamine.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.06.036
      Issue No: Vol. 178, No. 4 (2019)
  • Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake
           and Sperm Maturation
    • Authors: Bruno Hudry; Eva de Goeij, Alessandro Mineo, Pedro Gaspar, Dafni Hadjieconomou, Chris Studd, Joao B. Mokochinski, Holger B. Kramer, Pierre-Yves Plaçais, Thomas Preat, Irene Miguel-Aliaga
      Pages: 901 - 918.e16
      Abstract: Inter-organ communication couples diet with gamete production. The male gonad promotes sex differences in carbohydrate metabolism within an adjacent intestinal portion via JAK-STAT signalling. In response to this gonadal signal, gut-derived citrate controls food intake and sperm maturation.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.029
      Issue No: Vol. 178, No. 4 (2019)
  • Opposing Functions of Interferon Coordinate Adaptive and Innate Immune
           Responses to Cancer Immune Checkpoint Blockade
    • Authors: Joseph L. Benci; Lexus R. Johnson, Ruth Choa, Yuanming Xu, Jingya Qiu, Zilu Zhou, Bihui Xu, Darwin Ye, Katherine L. Nathanson, Carl H. June, E. John Wherry, Nancy R. Zhang, Hemant Ishwaran, Matthew D. Hellmann, Jedd D. Wolchok, Taku Kambayashi, Andy J. Minn
      Pages: 933 - 948.e14
      Abstract: The opposing effects of interferon-gamma in terms of regulating immune function but also driving T cell exhaustion through PDL1 is explained by its differential effects in tumor and immune cell populations.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.019
      Issue No: Vol. 178, No. 4 (2019)
  • A Heterochromatin-Specific RNA Export Pathway Facilitates piRNA Production
    • Authors: Mostafa F. ElMaghraby; Peter Refsing Andersen, Florian Pühringer, Ulrich Hohmann, Katharina Meixner, Thomas Lendl, Laszlo Tirian, Julius Brennecke
      Pages: 964 - 979.e20
      Abstract: Heterochromatic piRNA precursors escape classic mRNA quality-control and surveillance mechanisms through a dedicated nuclear export pathway.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.007
      Issue No: Vol. 178, No. 4 (2019)
  • Convergent Structures Illuminate Features for Germline Antibody Binding
           and Pan-Lassa Virus Neutralization
    • Authors: Kathryn M. Hastie; Robert W. Cross, Stephanie S. Harkins, Michelle A. Zandonatti, Anatoliy P. Koval, Megan L. Heinrich, Megan M. Rowland, James E. Robinson, Thomas W. Geisbert, Robert F. Garry, Luis M. Branco, Erica Ollmann Saphire
      Pages: 1004 - 1015.e14
      Abstract: Structural studies identify antibody features that provide potent neutralization against Lassa virus.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.020
      Issue No: Vol. 178, No. 4 (2019)
  • T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell
    • Authors: Tomasz Kula; Mohammad H. Dezfulian, Charlotte I. Wang, Nouran S. Abdelfattah, Zachary C. Hartman, Kai W. Wucherpfennig, Herbert Kim Lyerly, Stephen J. Elledge
      Pages: 1016 - 1028.e13
      Abstract: T-Scan is a cell-based, pooled screening approach for high-throughput identification of antigens productively recognized by T cells.
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.009
      Issue No: Vol. 178, No. 4 (2019)
  • BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain
    • Authors: Patrick-Simon Welz; Valentina M. Zinna, Aikaterini Symeonidi, Kevin B. Koronowski, Kenichiro Kinouchi, Jacob G. Smith, Inés Marín Guillén, Andrés Castellanos, Stephen Furrow, Ferrán Aragón, Georgiana Crainiciuc, Neus Prats, Juan Martín Caballero, Andrés Hidalgo, Paolo Sassone-Corsi, Salvador Aznar Benitah
      First page: 1029
      Abstract: (Cell 177, 1436–1447.e1–e12; May 30, 2019)
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.030
      Issue No: Vol. 178, No. 4 (2019)
  • VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells
    • Authors: Justin G. English; Reid H.J. Olsen, Katherine Lansu, Michael Patel, Karoline White, Adam S. Cockrell, Darshan Singh, Ryan T. Strachan, Daniel Wacker, Bryan L. Roth
      First page: 1030
      Abstract: (Cell 178, 748–761.e1–e17; July 25, 2019)
      Citation: Cell 178, 4 (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.036
      Issue No: Vol. 178, No. 4 (2019)
  • Diseases Have No Borders, Neither Should Research!
    • Authors: Xiaoliang Sunney Xie
      Abstract: In response to recent anti-Chinese sentiment in the US, Sunney Xie uses his own experiences to assert that American ideals should not be replaced by nationalism and populism and that everybody wins in Sino-US scientific collaborations, contrary to what Americans are led to believe—that China is the sole beneficiary.
      Citation: Cell (2019)
      PubDate: 2019-08-15
      DOI: 10.1016/j.cell.2019.07.053
  • GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
    • Authors: Harding Luan; Andrew Wang, Brandon Hilliard, Fernando Carvalho, Connor Rosen, Amy Ahasic, Erica Herzog, Insoo Kang, Margaret Pisani, Shuang Yu, Cuiling Zhang, Aaron Ring, Lawrence Young, Ruslan Medzhitov
      Abstract: Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. We found that inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. Indeed, we found that GDF15 was required for hepatic sympathetic outflow and triglyceride metabolism.
      Citation: Cell (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.033
  • Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel
    • Authors: Hila Sberro; Brayon J. Fremin, Soumaya Zlitni, Fredrik Edfors, Nicholas Greenfield, Michael P. Snyder, Georgios A. Pavlopoulos, Nikos C. Kyrpides, Ami S. Bhatt
      Abstract: Computational identification and characterization of thousands of conserved small ORFs from human microbiome sequences spanning multiple anatomical sites suggests a diversity of unknown protein domains and families with diverse functions.
      Citation: Cell (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.016
  • A Pliable Mediator Acts as a Functional Rather Than an Architectural
           Bridge between Promoters and Enhancers
    • Authors: Laila El Khattabi; Haiyan Zhao, Jens Kalchschmidt, Natalie Young, Seolkyoung Jung, Peter Van Blerkom, Philippe Kieffer-Kwon, Kyong-Rim Kieffer-Kwon, Solji Park, Xiang Wang, Jordan Krebs, Subhash Tripathi, Noboru Sakabe, Débora R. Sobreira, Su-Chen Huang, Suhas S.P. Rao, Nathanael Pruett, Daniel Chauss, Erica Sadler, Andrea Lopez, Marcelo A. Nóbrega, Erez Lieberman Aiden, Francisco J. Asturias, Rafael Casellas
      Abstract: A structurally-conserved Mediator promotes and controls interactions between enhancers and promoters but is not itself necessary to tether these elements.
      Citation: Cell (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.011
  • Molecular Strategies of Meiotic Cheating by Selfish Centromeres
    • Authors: Takashi Akera; Emily Trimm, Michael A. Lampson
      Abstract: The enrichment of microtubule-destabilizing activity on selfish centromeres provides a mechanistic basis for centromere drive.
      Citation: Cell (2019)
      PubDate: 2019-08-08
      DOI: 10.1016/j.cell.2019.07.001
  • An Integrative Model of Cellular States, Plasticity, and Genetics for
    • Authors: Cyril Neftel; Julie Laffy, Mariella G. Filbin, Toshiro Hara, Marni E. Shore, Gilbert J. Rahme, Alyssa R. Richman, Dana Silverbush, McKenzie L. Shaw, Christine M. Hebert, John Dewitt, Simon Gritsch, Elizabeth M. Perez, L. Nicolas Gonzalez Castro, Xiaoyang Lan, Nicholas Druck, Christopher Rodman, Danielle Dionne, Alexander Kaplan, Mia S. Bertalan, Julia Small, Kristine Pelton, Sarah Becker, Dennis Bonal, Quang-De Nguyen, Rachel L. Servis, Jeremy M. Fung, Ravindra Mylvaganam, Lisa Mayr, Johannes Gojo, Christine Haberler, Rene Geyeregger, Thomas Czech, Irene Slavc, Brian V. Nahed, William T. Curry, Bob S. Carter, Hiroaki Wakimoto, Priscilla K. Brastianos, Tracy T. Batchelor, Anat Stemmer-Rachamimov, Maria Martinez-Lage, Matthew P. Frosch, Ivan Stamenkovic, Nicolo Riggi, Esther Rheinbay, Michelle Monje, Orit Rozenblatt-Rosen, Daniel P. Cahill, Anoop P. Patel, Tony Hunter, Inder M. Verma, Keith L. Ligon, David N. Louis, Aviv Regev, Bradley E. Bernstein, Itay Tirosh, Mario L. Suvà
      First page: 835
      Abstract: Single-cell analyses of glioblastoma samples reveal multiple cellular states, their plasticity and the genetic underpinnings of state proportions in a given tumor.
      Citation: Cell (2019)
      PubDate: 2019-07-18
      DOI: 10.1016/j.cell.2019.06.024
  • Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory
    • Authors: Jonathan A. Cohen; Tara N. Edwards, Andrew W. Liu, Toshiro Hirai, Marsha Ritter Jones, Jianing Wu, Yao Li, Shiqun Zhang, Jonhan Ho, Brian M. Davis, Kathryn M. Albers, Daniel H. Kaplan
      First page: 919
      Abstract: Cutaneous sensory neurons can trigger an inflammatory reflex arc that activates anticipatory immunity in the neighboring skin.
      Citation: Cell (2019)
      PubDate: 2019-07-25
      DOI: 10.1016/j.cell.2019.06.022
  • Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its
    • Authors: Jane Guan; Wei Zhou, Marc Hafner, Robert A. Blake, Cecile Chalouni, Irene P. Chen, Tom De Bruyn, Jennifer M. Giltnane, Steven J. Hartman, Amy Heidersbach, Rene Houtman, Ellen Ingalla, Lorn Kategaya, Tracy Kleinheinz, Jun Li, Scott E. Martin, Zora Modrusan, Michelle Nannini, Jason Oeh, Savita Ubhayakar, Xiaojing Wang, Ingrid E. Wertz, Amy Young, Mamie Yu, Deepak Sampath, Jeffrey H. Hager, Lori S. Friedman, Anneleen Daemen, Ciara Metcalfe
      First page: 949
      Abstract: Ligands that limit estrogen receptor mobility exhibit superior anti-proliferative capacity compared to those aimed solely at promoting ER degradation, pointing to a distinct approach for developing treatments for ER+ breast cancer.
      Citation: Cell (2019)
      PubDate: 2019-07-25
      DOI: 10.1016/j.cell.2019.06.026
  • Repressive Gene Regulation Synchronizes Development with Cellular
    • Authors: Justin J. Cassidy; Sebastian M. Bernasek, Rachael Bakker, Ritika Giri, Nicolás Peláez, Bryan Eder, Anna Bobrowska, Neda Bagheri, Luis A. Nunes Amaral, Richard W. Carthew
      First page: 980
      Abstract: microRNAs become dispensable for development in the context of slower metabolism.
      Citation: Cell (2019)
      PubDate: 2019-07-25
      DOI: 10.1016/j.cell.2019.06.023
  • Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium
    • Authors: Goragot Wisedchaisri; Lige Tonggu, Eedann McCord, Tamer M. Gamal El-Din, Liguo Wang, Ning Zheng, William A. Catterall
      First page: 993
      Abstract: An engineered bacterial NaV channel adopts a resting conformation in the absence of a membrane potential, enabling structural analysis and elucidation of the full voltage-dependent gating mechanism.
      Citation: Cell (2019)
      PubDate: 2019-07-25
      DOI: 10.1016/j.cell.2019.06.031
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