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Journal Cover
Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 979  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3159 journals]
  • Enhancing Therapy: It’s about Time
    • Authors: Myles Brown
      Pages: 771 - 772
      Abstract: How diet and obesity impact diurnal changes in physiology remains unclear. In this issue of Cell, Guan et al. report that diet-induced obesity modulates the activity of circadian gene enhancers including those regulating lipid metabolism and show that the efficacy of lipid-lowering drugs depends on the time of administration.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.037
      Issue No: Vol. 174, No. 4 (2018)
       
  • Viral Teamwork Pushes CRISPR to the Breaking Point
    • Authors: Philip M. Nussenzweig; Luciano A. Marraffini
      Pages: 772 - 774
      Abstract: Viruses have evolved inhibitors to counteract the CRISPR immune response, but they are not fully potent and need some time to be expressed after the beginning of infection. In this issue of Cell, Borges et al. and Landsberger et al. show that sequential infection gradually immunosuppresses the host to allow effective CRISPR inhibition.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.025
      Issue No: Vol. 174, No. 4 (2018)
       
  • Single-Molecule Analysis of a Viral Fusion Protein Illuminates a
           Fusion-Active Intermediate State
    • Authors: Mark Benhaim; Kelly K. Lee
      Pages: 775 - 777
      Abstract: The influenza virus hemagglutinin (HA) fusion glycoprotein mediates viral entry into host cells through its receptor binding and membrane fusion activities. In this issue of Cell, Das et al. use single-molecule Förster resonance energy transfer (smFRET) to monitor HA conformational dynamics. Their study reveals this prototypical class I fusion protein to be a highly dynamic molecule capable of reversibly sampling multiple states, including on-pathway fusion intermediates between pre-fusion and post-fusion endpoints. These findings challenge long-held ideas for how HA functions and move the field closer to obtaining a mechanistic understanding of how class I fusion proteins mediate membrane fusion.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.026
      Issue No: Vol. 174, No. 4 (2018)
       
  • Sequencing Diversity One Cell at a Time
    • Authors: Michael C. Oldham; Anatol C. Kreitzer
      Pages: 777 - 779
      Abstract: Single-cell RNA sequencing provides a new approach to an old problem: how to study cellular diversity in complex biological systems. Three studies—Saunders et al., Zeisel et al., and Davie et al.—deploy this technique on an unprecedented scale to reveal transcriptional patterns that distinguish cells in the nervous systems of mice and flies.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.024
      Issue No: Vol. 174, No. 4 (2018)
       
  • Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as
           Signal Transducers
    • Authors: Michael P. Murphy; Luke A.J. O’Neill
      Pages: 780 - 784
      Abstract: The metabolites succinate and itaconate have emerged as key signaling molecules linking mitochondrial function to the rest of the cell across several areas of cell function.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.030
      Issue No: Vol. 174, No. 4 (2018)
       
  • Microbiome: Focus on Causation and Mechanism
    • Authors: Michael A. Fischbach
      Pages: 785 - 790
      Abstract: The microbiome field, argues this Perspective, needs to focus on establishing causation and molecular mechanism, with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by the microbiota.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.038
      Issue No: Vol. 174, No. 4 (2018)
       
  • Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies
    • Authors: Briana Van Treeck; Roy Parker
      Pages: 791 - 802
      Abstract: RNA-RNA interactions may play a role in dictating the composition of ribonucleoprotein granules such as stress granules and repeat-expansion-associated foci and may therefore have a role in a number of degenerative diseases.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.023
      Issue No: Vol. 174, No. 4 (2018)
       
  • Divergent Routes toward Wnt and R-spondin Niche Independency during Human
           Gastric Carcinogenesis
    • Authors: Kosaku Nanki; Kohta Toshimitsu, Ai Takano, Masayuki Fujii, Mariko Shimokawa, Yuki Ohta, Mami Matano, Takashi Seino, Shingo Nishikori, Keiko Ishikawa, Kenta Kawasaki, Kazuhiro Togasaki, Sirirat Takahashi, Yasutaka Sukawa, Hiroki Ishida, Shinya Sugimoto, Hirofumi Kawakubo, Jihoon Kim, Yuko Kitagawa, Shigeki Sekine, Bon-Kyoung Koo, Takanori Kanai, Toshiro Sato
      Pages: 856 - 869.e17
      Abstract: Generation and analysis of a human gastric cancer organoid bank reveal insights into molecular features underlying diverse histopathological subtypes and tumor independence from Wnt signals.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.027
      Issue No: Vol. 174, No. 4 (2018)
       
  • Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP
           Defines Features that Contribute to Protection
    • Authors: Erica Ollmann Saphire; Sharon L. Schendel, Marnie L. Fusco, Karthik Gangavarapu, Bronwyn M. Gunn, Anna Z. Wec, Peter J. Halfmann, Jennifer M. Brannan, Andrew S. Herbert, Xiangguo Qiu, Kshitij Wagh, Shihua He, Elena E. Giorgi, James Theiler, Kathleen B.J. Pommert, Tyler B. Krause, Hannah L. Turner, Charles D. Murin, Jesper Pallesen, Edgar Davidson, Rafi Ahmed, M. Javad Aman, Alexander Bukreyev, Dennis R. Burton, James E. Crowe, Carl W. Davis, George Georgiou, Florian Krammer, Christos A. Kyratsous, Jonathan R. Lai, Cory Nykiforuk, Michael H. Pauly, Pramila Rijal, Ayato Takada, Alain R. Townsend, Viktor Volchkov, Laura M. Walker, Cheng-I. Wang, Larry Zeitlin, Benjamin J. Doranz, Andrew B. Ward, Bette Korber, Gary P. Kobinger, Kristian G. Andersen, Yoshihiro Kawaoka, Galit Alter, Kartik Chandran, John M. Dye, the Viral Hemorrhagic Fever Immunotherapeutic Consortium
      Pages: 938 - 952.e13
      Abstract: The systematic assessment of the effector functions and binding sites of antibodies against Ebola virus provides a generalizable framework to evaluate the determinants of antibody-mediated protection in viral disease.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.033
      Issue No: Vol. 174, No. 4 (2018)
       
  • Molecular Architecture of the Mouse Nervous System
    • Authors: Amit Zeisel; Hannah Hochgerner, Peter Lönnerberg, Anna Johnsson, Fatima Memic, Job van der Zwan, Martin Häring, Emelie Braun, Lars E. Borm, Gioele La Manno, Simone Codeluppi, Alessandro Furlan, Kawai Lee, Nathan Skene, Kenneth D. Harris, Jens Hjerling-Leffler, Ernest Arenas, Patrik Ernfors, Ulrika Marklund, Sten Linnarsson
      Pages: 999 - 1014.e22
      Abstract: Single-cell transcriptional profiling of the adult mouse nervous system uncovers new cell classes and types across regions, providing a clearer picture of cell diversity by region and a reference atlas for studying the mammalian nervous system.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.06.021
      Issue No: Vol. 174, No. 4 (2018)
       
  • Molecular Diversity and Specializations among the Cells of the Adult Mouse
           Brain
    • Authors: Arpiar Saunders; Evan Z. Macosko, Alec Wysoker, Melissa Goldman, Fenna M. Krienen, Heather de Rivera, Elizabeth Bien, Matthew Baum, Laura Bortolin, Shuyu Wang, Aleksandrina Goeva, James Nemesh, Nolan Kamitaki, Sara Brumbaugh, David Kulp, Steven A. McCarroll
      Pages: 1015 - 1030.e16
      Abstract: Sampling across multiple brain regions identifies hundreds of transcriptionally distinct groups of cells and reveals large-scale features of brain organization and neuronal diversity.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.028
      Issue No: Vol. 174, No. 4 (2018)
       
  • Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and
           Improves Anti-PD-1 Immunotherapy
    • Authors: Antoni Ribas; Reinhard Dummer, Igor Puzanov, Ari VanderWalde, Robert H.I. Andtbacka, Olivier Michielin, Anthony J. Olszanski, Josep Malvehy, Jonathan Cebon, Eugenio Fernandez, John M. Kirkwood, Thomas F. Gajewski, Lisa Chen, Kevin S. Gorski, Abraham A. Anderson, Scott J. Diede, Michael E. Lassman, Jennifer Gansert, F. Stephen Hodi, Georgina V. Long
      Pages: 1031 - 1032
      Abstract: (Cell 170, 1109–1119.e1–e4; September 7, 2017)
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.035
      Issue No: Vol. 174, No. 4 (2018)
       
  • Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
    • Authors: A. Gordon Robertson; Jaegil Kim, Hikmat Al-Ahmadie, Joaquim Bellmunt, Guangwu Guo, Andrew D. Cherniack, Toshinori Hinoue, Peter W. Laird, Katherine A. Hoadley, Rehan Akbani, Mauro A.A. Castro, Ewan A. Gibb, Rupa S. Kanchi, Dmitry A. Gordenin, Sachet A. Shukla, Francisco Sanchez-Vega, Donna E. Hansel, Bogdan A. Czerniak, Victor E. Reuter, Xiaoping Su, Benilton de Sa Carvalho, Vinicius S. Chagas, Karen L. Mungall, Sara Sadeghi, Chandra Sekhar Pedamallu, Yiling Lu, Leszek J. Klimczak, Jiexin Zhang, Caleb Choo, Akinyemi I. Ojesina, Susan Bullman, Kristen M. Leraas, Tara M. Lichtenberg, Catherine J. Wu, Nicholaus Schultz, Gad Getz, Matthew Meyerson, Gordon B. Mills, David J. McConkey, TCGA Research Network, John N. Weinstein, David J. Kwiatkowski, Seth P. Lerner
      First page: 1033
      Abstract: (Cell 171, 540–556; October 19, 2017)
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.036
      Issue No: Vol. 174, No. 4 (2018)
       
  • Comprehensive Characterization of Cancer Driver Genes and Mutations
    • Authors: Matthew H. Bailey; Collin Tokheim, Eduard Porta-Pardo, Sohini Sengupta, Denis Bertrand, Amila Weerasinghe, Antonio Colaprico, Michael C. Wendl, Jaegil Kim, Brendan Reardon, Patrick Kwok-Shing Ng, Kang Jin Jeong, Song Cao, Zixing Wang, Jianjiong Gao, Qingsong Gao, Fang Wang, Eric Minwei Liu, Loris Mularoni, Carlota Rubio-Perez, Niranjan Nagarajan, Isidro Cortés-Ciriano, Daniel Cui Zhou, Wen-Wei Liang, Julian M. Hess, Venkata D. Yellapantula, David Tamborero, Abel Gonzalez-Perez, Chayaporn Suphavilai, Jia Yu Ko, Ekta Khurana, Peter J. Park, Eliezer M. Van Allen, Han Liang, The MC3 Working Group, The Cancer Genome Atlas Research Network, Michael S. Lawrence, Adam Godzik, Nuria Lopez-Bigas, Josh Stuart, David Wheeler, Gad Getz, Ken Chen, Alexander J. Lazar, Gordon B. Mills, Rachel Karchin, Li Ding
      Pages: 1034 - 1035
      Abstract: (Cell 173, 371–385.e1–e9; April 5, 2018)
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.034
      Issue No: Vol. 174, No. 4 (2018)
       
  • Dissociable Structural and Functional Hippocampal Outputs via Distinct
           Subiculum Cell Classes
    • Authors: Mark S. Cembrowski; Matthew G. Phillips, Salvatore F. DiLisio, Brenda C. Shields, Johan Winnubst, Jayaram Chandrashekar, Erhan Bas, Nelson Spruston
      First page: 1036
      Abstract: (Cell 173, 1280–1292; May 17, 2018)
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.039
      Issue No: Vol. 174, No. 4 (2018)
       
  • SnapShot: Unconventional miRNA Functions
    • Authors: Mihnea Paul Dragomir; Erik Knutsen, George Adrian Calin
      Pages: 1038 - 1038.e1
      Abstract: MicroRNAs (miRNAs) are synonymous with post-transcriptional repression of target genes. A number of studies, however, have reported miRNAs functioning outside this paradigm, and this SnapShot outlines these unconventional ways in which miRNAs can exert regulatory functions. To view this SnapShot, open or download the PDF.
      Citation: Cell 174, 4 (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.040
      Issue No: Vol. 174, No. 4 (2018)
       
  • Structure and Conformational Dynamics of a COMPASS Histone H3K4
           Methyltransferase Complex
    • Authors: Qianhui Qu; Yoh-hei Takahashi, Yidai Yang, Hongli Hu, Yan Zhang, Joseph S. Brunzelle, Jean-Francois Couture, Ali Shilatifard, Georgios Skiniotis
      Abstract: The cryo-EM structure of a fully functional COMPASS complex reveals the intricate structural coordination of the methyltransferase subunit by its partner proteins.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.020
       
  • Urea Cycle Dysregulation Generates Clinically Relevant Genomic and
           Biochemical Signatures
    • Authors: Joo Sang Lee; Lital Adler, Hiren Karathia, Narin Carmel, Shiran Rabinovich, Noam Auslander, Rom Keshet, Noa Stettner, Alon Silberman, Lilach Agemy, Daniel Helbling, Raya Eilam, Qin Sun, Alexander Brandis, Sergey Malitsky, Maxim Itkin, Hila Weiss, Sivan Pinto, Shelly Kalaora, Ronen Levy, Eilon Barnea, Arie Admon, David Dimmock, Noam Stern-Ginossar, Avigdor Scherz, Sandesh C.S. Nagamani, Miguel Unda, David M. Wilson, Ronit Elhasid, Arkaitz Carracedo, Yardena Samuels, Sridhar Hannenhalli, Eytan Ruppin, Ayelet Erez
      Abstract: Urea cycle dysregulation (UCD) in cancer is a prevalent phenomenon in multiple cancers. UCD increases nitrogen utilization for pyrimidine synthesis, generating nucleotide imbalance that leads to detectable mutation patterns and biochemical signatures in cancer patients’ samples. UCD is associated with a worse prognosis but a better response to immunotherapy.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.019
       
  • Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic
           Infection and Select for Attenuated Virulence in an Enteric Pathogen
    • Authors: Karina K. Sanchez; Grischa Y. Chen, Alexandria M. Palaferri Schieber, Samuel E. Redford, Maxim N. Shokhirev, Mathias Leblanc, Yujung M. Lee, Janelle S. Ayres
      Abstract: Defense strategies that are cooperative rather than antagonistic can promote asymptomatic infection and select for reduced virulence in a bacterial pathogen.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.016
       
  • Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven
           E2F1, MYC, and AR Nuclear Import
    • Authors: Veronica Rodriguez-Bravo; Raffaella Pippa, Won-Min Song, Marc Carceles-Cordon, Ana Dominguez-Andres, Naoto Fujiwara, Jungreem Woo, Anna P. Koh, Adam Ertel, Ravi K. Lokareddy, Alvaro Cuesta-Dominguez, Rosa S. Kim, Irene Rodriguez-Fernandez, Peiyao Li, Ronald Gordon, Hadassa Hirschfield, Josep M. Prats, E. Premkumar Reddy, Alessandro Fatatis, Daniel P. Petrylak, Leonard Gomella, W. Kevin Kelly, Scott W. Lowe, Karen E. Knudsen, Matthew D. Galsky, Gino Cingolani, Amaia Lujambio, Yujin Hoshida, Josep Domingo-Domenech
      Abstract: POM121- and importin β-mediated nuclear import of a subset of oncogenic transcription factors promotes prostate cancer aggressiveness and reveals a pharmacologically targetable dependency.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.015
       
  • Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis
    • Authors: Tao Yu; Yongjin J. Zhou, Mingtao Huang, Quanli Liu, Rui Pereira, Florian David, Jens Nielsen
      Abstract: Integrated biological redesign, including metabolic rewiring, directed evolution, and bioprocess optimization, allows for reprogramming of S. cerevisiae into a synthetic oil yeast.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.013
       
  • Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood
           Lymphocytes and Tumor Organoids
    • Authors: Krijn K. Dijkstra; Chiara M. Cattaneo, Fleur Weeber, Myriam Chalabi, Joris van de Haar, Lorenzo F. Fanchi, Maarten Slagter, Daphne L. van der Velden, Sovann Kaing, Sander Kelderman, Nienke van Rooij, Monique E. van Leerdam, Annekatrien Depla, Egbert F. Smit, Koen J. Hartemink, Rosa de Groot, Monika C. Wolkers, Norman Sachs, Petur Snaebjornsson, Kim Monkhorst, John Haanen, Hans Clevers, Ton N. Schumacher, Emile E. Voest
      Abstract: A modified patient-derived tumor organoids system allows the expansion of tumor-specific T cells from blood for personalized analysis of their anti-cancer properties.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.009
       
  • Pathway of Actin Folding Directed by the Eukaryotic Chaperonin TRiC
    • Authors: David Balchin; Goran Miličić, Mike Strauss, Manajit Hayer-Hartl, F. Ulrich Hartl
      Abstract: Single-molecule studies explain why the eukaryotic chaperone complex TRiC, but not the simpler bacterial chaperonin system, is able to induce the proper folding of actin.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.006
       
  • Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships
    • Authors: Peng Zhang; Hong Lu, Rui T. Peixoto, Mary K. Pines, Yuan Ge, Shinichiro Oku, Tabrez J. Siddiqui, Yicheng Xie, Wenlan Wu, Stephanie Archer-Hartmann, Keitaro Yoshida, Kenji F. Tanaka, A. Radu Aricescu, Parastoo Azadi, Michael D. Gordon, Bernardo L. Sabatini, Rachel O.L. Wong, Ann Marie Craig
      Abstract: Neurexins, major synaptic-organizing proteins, are heparan sulfate (HS) proteoglycans, and HS modification is required for neurexin functions in synaptic transmission, development, and behavior.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.07.002
       
  • Crystal Structure of the COMPASS H3K4 Methyltransferase Catalytic Module
    • Authors: Peter L. Hsu; Heng Li, Ho-Tak Lau, Calvin Leonen, Abhinav Dhall, Shao-En Ong, Champak Chatterjee, Ning Zheng
      Abstract: The crystal structure of the yeast COMPASS histone methyltransferase catalytic module reveals a doorstop-style mechanism dictating substrate selectivity.
      Citation: Cell (2018)
      PubDate: 2018-08-09
      DOI: 10.1016/j.cell.2018.06.038
       
  • Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork
           Collapse
    • Authors: Anthony Tubbs; Sriram Sridharan, Niek van Wietmarschen, Yaakov Maman, Elsa Callen, Andre Stanlie, Wei Wu, Xia Wu, Amanda Day, Nancy Wong, Mianmian Yin, Andres Canela, Haiqing Fu, Christophe Redon, Steven C. Pruitt, Yan Jaszczyszyn, Mirit I. Aladjem, Peter D. Aplan, Olivier Hyrien, André Nussenzweig
      Abstract: Mammalian replication origins are fragile sites defined by poly-dA/dT stretches that are nucleosome free and devoid of the single-strand DNA-protecting protein RPA.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.011
       
  • Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral
           Ganglion Subtype Specification in the Auditory System
    • Authors: Shuohao Sun; Travis Babola, Gabriela Pregernig, Kathy S. So, Matthew Nguyen, Shin-San M. Su, Adam T. Palermo, Dwight E. Bergles, Joseph C. Burns, Ulrich Müller
      Abstract: Single-cell analyses of mouse type I spiral ganglion neurons characterize three functionally distinct subtypes, revealing insights into auditory processing with implications for treating congenital deafness.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.008
       
  • Sensory Neuron Diversity in the Inner Ear Is Shaped by Activity
    • Authors: Brikha R. Shrestha; Chester Chia, Lorna Wu, Sharon G. Kujawa, M. Charles Liberman, Lisa V. Goodrich
      Abstract: Using single-cell RNA sequencing, Shrestha and colleagues define three subtypes of inner ear neurons with differential expression of physiologically relevant molecules across subtypes and tonotopically. SGN diversification begins postnatally and requires IHC-driven activity, with implications for age-related and congenital deafness.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.007
       
  • Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing
    • Authors: Jan Attig; Federico Agostini, Clare Gooding, Anob M. Chakrabarti, Aarti Singh, Nejc Haberman, Julian A. Zagalak, Warren Emmett, Christopher W.J. Smith, Nicholas M. Luscombe, Jernej Ule
      Abstract: LINE elements recruit RNA-binding proteins to mammalian introns, influencing splicing and playing a key role in the evolution of tissue-specific exons.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.001
       
  • Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2
           Regulatory Circuit
    • Authors: Nathan Meade; Colleen Furey, Hua Li, Rita Verma, Qingqing Chai, Madeline G. Rollins, Stephen DiGiuseppe, Mojgan H. Naghavi, Derek Walsh
      Abstract: Poxviruses disrupt an mTOR regulatory circuit via a small protein that sequesters Raptor and Rictor, allowing the virus to evade cGAS-STING sensing while reaping the metabolic benefits of mTOR activity.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.06.053
       
  • A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility
    • Authors: Darren A. Cusanovich; Andrew J. Hill, Delasa Aghamirzaie, Riza M. Daza, Hannah A. Pliner, Joel B. Berletch, Galina N. Filippova, Xingfan Huang, Lena Christiansen, William S. DeWitt, Choli Lee, Samuel G. Regalado, David F. Read, Frank J. Steemers, Christine M. Disteche, Cole Trapnell, Jay Shendure
      Abstract: Profiling chromatin accessibility at single-cell resolution across 13 tissues in mice identifies 85 distinct patterns and a catalog of ∼400,000 potential regulatory elements, presenting a resource for understanding the chromatin regulatory landscape of diverse mammalian cell types and for interpreting human genome-wide association studies.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.06.052
       
  • No Evidence for Recent Selection at FOXP2 among Diverse Human Populations
    • Authors: Elizabeth Grace Atkinson; Amanda Jane Audesse, Julia Adela Palacios, Dean Michael Bobo, Ashley Elizabeth Webb, Sohini Ramachandran, Brenna Mariah Henn
      Abstract: An in-depth examination of diverse sets of human genomes argues against a recent selective evolutionary sweep of FOXP2, a gene that was believed to be critical for speech evolution in early hominins.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.06.048
       
  • Reconstituted Postsynaptic Density as a Molecular Platform for
           Understanding Synapse Formation and Plasticity
    • Authors: Menglong Zeng; Xudong Chen, Dongshi Guan, Jia Xu, Haowei Wu, Penger Tong, Mingjie Zhang
      Abstract: Phase transition-mediated formation of excitatory postsynaptic density condensates revealed by biochemical reconstitutions.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.06.047
       
  • Global DNA Compaction in Stationary-Phase Bacteria Does Not Affect
           Transcription
    • Authors: Richard Janissen; Mathia M.A. Arens, Natalia N. Vtyurina, Zaïda Rivai, Nicholas D. Sunday, Behrouz Eslami-Mossallam, Alexey A. Gritsenko, Liedewij Laan, Dick de Ridder, Irina Artsimovitch, Nynke H. Dekker, Elio A. Abbondanzieri, Anne S. Meyer
      Abstract: Despite markedly condensing the bacterial chromosome, the nucleoid-structuring protein Dps selectively allows access by RNA polymerase and transcription factors at normal rates while excluding other factors such as restriction endonucleases.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.049
       
  • RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation
           Caused by Intronic Repeat Expansions
    • Authors: Hannes Eimer; Sridevi Sureshkumar, Avilash Singh Yadav, Calvin Kraupner-Taylor, Champa Bandaranayake, Andrei Seleznev, Tamblyn Thomason, Stephen J. Fletcher, Stephanie Frances Gordon, Bernard J. Carroll, Sureshkumar Balasubramanian
      Abstract: Triplet expansions within an Arabidopsis gene leads to local siRNA biogenesis and consequent transcriptional downregulation, suggesting how intronic repeat expansions may affect gene expression in other systems.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.044
       
  • Hijacking Oogenesis Enables Massive Propagation of LINE and Retroviral
           Transposons
    • Authors: Lu Wang; Kun Dou, Sungjin Moon, Frederick J. Tan, ZZ Zhao Zhang
      Abstract: Transposons capitalize on developmental regulation in oocytes to ensure heritable transmission.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.040
       
  • Progenitor Hyperpolarization Regulates the Sequential Generation of
           Neuronal Subtypes in the Developing Neocortex
    • Authors: Ilaria Vitali; Sabine Fièvre, Ludovic Telley, Polina Oberst, Sebastiano Bariselli, Laura Frangeul, Natalia Baumann, John J. McMahon, Esther Klingler, Riccardo Bocchi, Jozsef Z. Kiss, Camilla Bellone, Debra L. Silver, Denis Jabaudon
      Abstract: Progressive changes in the membrane potential of neural progenitors during corticogenesis coordinate the successive generation of distinct neuronal subtypes.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.036
       
  • Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase
           PPP1R15B
    • Authors: Agnieszka Krzyzosiak; Anna Sigurdardottir, Laura Luh, Marta Carrara, Indrajit Das, Kim Schneider, Anne Bertolotti
      Abstract: An orally available selective phosphatase inhibitor improves proteostasis and diminishes deficits in a mouse model of Huntington’s disease.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.030
       
  • An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a
           Central Viral Receptor
    • Authors: Nadia Martinez-Martin; Jessica Marcandalli, Christine S. Huang, Christopher P. Arthur, Michela Perotti, Mathilde Foglierini, Hoangdung Ho, Annie M. Dosey, Stephanie Shriver, Jian Payandeh, Alexander Leitner, Antonio Lanzavecchia, Laurent Perez, Claudio Ciferri
      Abstract: A high-throughput screen for high-sensitivity detection of receptor-ligand interactions is used to identify long-sought cell-surface receptors responsible for human cytomegalovirus (HCMV) infection.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.028
       
  • Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor
           Microenvironment
    • Authors: Elham Azizi; Ambrose J. Carr, George Plitas, Andrew E. Cornish, Catherine Konopacki, Sandhya Prabhakaran, Juozas Nainys, Kenmin Wu, Vaidotas Kiseliovas, Manu Setty, Kristy Choi, Rachel M. Fromme, Phuong Dao, Peter T. McKenney, Ruby C. Wasti, Krishna Kadaveru, Linas Mazutis, Alexander Y. Rudensky, Dana Pe’er
      Abstract: Single-cell analysis of the breast tumor immune microenvironment, coupled with computational analysis, yields an immune map of breast cancer that points to continuous T cell activation and differentiation states.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.060
       
  • Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA
           Amplifications
    • Authors: Sweta Mishra; Capucine Van Rechem, Sangita Pal, Thomas L. Clarke, Damayanti Chakraborty, Sarah D. Mahan, Joshua C. Black, Michael S. Lawrence, Danette L. Daniels, Johnathan R. Whetstine
      First page: 803
      Abstract: Histone lysine methyltransferases and demethylases collaborate to promote site-specific DNA copy number gains.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.018
       
  • Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone
           H3 K56 by Rtt109
    • Authors: Lin Zhang; Albert Serra-Cardona, Hui Zhou, Mingzhu Wang, Na Yang, Zhiguo Zhang, Rui-Ming Xu
      First page: 818
      Abstract: A multiprotein complex of histone chaperone Asf1 and H3 and H4 as an intact substrate for a histone-modifying enzyme.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.07.005
       
  • Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic
           Lipid Metabolic Processes
    • Authors: Dongyin Guan; Ying Xiong, Patricia C. Borck, Cholsoon Jang, Paschalis-Thomas Doulias, Romeo Papazyan, Bin Fang, Chunjie Jiang, Yuxiang Zhang, Erika R. Briggs, Wenxiang Hu, David Steger, Harry Ischiropoulos, Joshua D. Rabinowitz, Mitchell A. Lazar
      First page: 831
      Abstract: Overnutrition intensifies hepatic circadian rhythms of non-core clock factors SREBP and PPARα such that pharmacological lipid lowering is more effective when PPARα is highest.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.031
       
  • Toward Minimal Residual Disease-Directed Therapy in Melanoma
    • Authors: Florian Rambow; Aljosja Rogiers, Oskar Marin-Bejar, Sara Aibar, Julia Femel, Michael Dewaele, Panagiotis Karras, Daniel Brown, Young Hwan Chang, Maria Debiec-Rychter, Carmen Adriaens, Enrico Radaelli, Pascal Wolter, Oliver Bechter, Reinhard Dummer, Mitchell Levesque, Adriano Piris, Dennie T. Frederick, Genevieve Boland, Keith T. Flaherty, Joost van den Oord, Thierry Voet, Stein Aerts, Amanda W. Lund, Jean-Christophe Marine
      First page: 843
      Abstract: Drug-tolerant cells that persist through treatment of melanoma exhibit multiple transcriptional states, one of which is a key driver that can be targeted therapeutically.
      Citation: Cell (2018)
      PubDate: 2018-07-12
      DOI: 10.1016/j.cell.2018.06.025
       
  • The Mitochondrial Unfolded Protein Response Is Mediated
           Cell-Non-autonomously by Retromer-Dependent Wnt Signaling
    • Authors: Qian Zhang; Xueying Wu, Peng Chen, Limeng Liu, Nan Xin, Ye Tian, Andrew Dillin
      First page: 870
      Abstract: The Wnt/EGL-20 relays mitochondrial stress signals from neurons to peripheral tissues.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.029
       
  • Systematic Nanoscale Analysis of Endocytosis Links Efficient Vesicle
           Formation to Patterned Actin Nucleation
    • Authors: Markus Mund; Johannes Albertus van der Beek, Joran Deschamps, Serge Dmitrieff, Philipp Hoess, Jooske Louise Monster, Andrea Picco, François Nédélec, Marko Kaksonen, Jonas Ries
      First page: 884
      Abstract: Superresolution analysis of endocytic vesicle assembly identifies a patterned actin template that orchestrates protein recruitment.
      Citation: Cell (2018)
      PubDate: 2018-07-26
      DOI: 10.1016/j.cell.2018.06.032
       
  • Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis
    • Authors: Nam Chu; Antonieta L. Salguero, Albert Z. Liu, Zan Chen, Daniel R. Dempsey, Scott B. Ficarro, William M. Alexander, Jarrod A. Marto, Yana Li, L. Mario Amzel, Sandra B. Gabelli, Philip A. Cole
      First page: 897
      Abstract: Dissecting the molecular interactions leading to Akt activation points to a chain of events distinct from existing models.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.003
       
  • Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity
    • Authors: Mariann Landsberger; Sylvain Gandon, Sean Meaden, Clare Rollie, Anne Chevallereau, Hélène Chabas, Angus Buckling, Edze R. Westra, Stineke van Houte
      First page: 908
      Abstract: Phage anti-CRISPR proteins weaken the host bacterium’s initial immune response, leading to immunosuppression and leaving the host vulnerable to future phage infection.
      Citation: Cell (2018)
      PubDate: 2018-07-19
      DOI: 10.1016/j.cell.2018.05.058
       
  • Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity
    • Authors: Adair L. Borges; Jenny Y. Zhang, MaryClare F. Rollins, Beatriz A. Osuna, Blake Wiedenheft, Joseph Bondy-Denomy
      First page: 917
      Abstract: A critical-threshold level of phage anti-CRISPR proteins is required for CRISPR resistance and infection of immune hosts, suggesting that anti-CRISPR systems may have evolved under conditions where the likelihood of multiple or sequential infection is high.
      Citation: Cell (2018)
      PubDate: 2018-07-19
      DOI: 10.1016/j.cell.2018.06.013
       
  • Direct Visualization of the Conformational Dynamics of Single Influenza
           Hemagglutinin Trimers
    • Authors: Dibyendu Kumar Das; Ramesh Govindan, Ivana Nikić-Spiegel, Florian Krammer, Edward A. Lemke, James B. Munro
      First page: 926
      Abstract: Single-molecule FRET is used to provide real-time visualization of influenza hemagglutinin conformational dynamics on the viral surface during triggering by low pH.
      Citation: Cell (2018)
      PubDate: 2018-06-28
      DOI: 10.1016/j.cell.2018.05.050
       
  • Mapping the Genetic Landscape of Human Cells
    • Authors: Max A. Horlbeck; Albert Xu, Min Wang, Neal K. Bennett, Chong Y. Park, Derek Bogdanoff, Britt Adamson, Eric D. Chow, Martin Kampmann, Tim R. Peterson, Ken Nakamura, Michael A. Fischbach, Jonathan S. Weissman, Luke A. Gilbert
      First page: 953
      Abstract: A large-scale genetic interaction map in human cells reveals unexpected interdependencies between core pathways and exposes potential combination therapies for cancer.
      Citation: Cell (2018)
      PubDate: 2018-07-19
      DOI: 10.1016/j.cell.2018.06.010
       
  • Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed
           Imaging
    • Authors: Yury Goltsev; Nikolay Samusik, Julia Kennedy-Darling, Salil Bhate, Matthew Hale, Gustavo Vazquez, Sarah Black, Garry P. Nolan
      First page: 968
      Abstract: A DNA barcoding-based imaging technique uses multiplexed tissue antigen staining to enable the characterization of cell types and dynamics in a model of autoimmune disease.
      Citation: Cell (2018)
      PubDate: 2018-08-02
      DOI: 10.1016/j.cell.2018.07.010
       
  • A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
    • Authors: Kristofer Davie; Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aerts
      First page: 982
      Abstract: A single-cell atlas of adult fly brains identifies the ensemble of neuronal and glial cell types and their dynamic changes during aging.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.057
       
 
 
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