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Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1031  
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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3155 journals]
  • CGRP Antibodies as Prophylaxis in Migraine
    • Authors: Lars Edvinsson
      First page: 1719
      Abstract: Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 2018. Two antibodies, fremanezumab and galcanezumab, directed towards the CGRP ligand, were approved by the FDA in September 2018. To view this Bench to Bedside, open or download the PDF.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.049
      Issue No: Vol. 175, No. 7 (2018)
  • NKG2A, a New Kid on the Immune Checkpoint Block
    • Authors: John B. Haanen; Vincenzo Cerundolo
      Pages: 1720 - 1722
      Abstract: One of the major breakthroughs of cancer immunotherapy has come from blocking immune checkpoint molecules on tumor-reactive T cells. Now, two studies examine targeting of a novel immune checkpoint, NKG2A, that can be expressed on both NK cells and on CD8+ T cells, either combined with a tumor-targeting antibody or with a tumor-specific vaccine.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.048
      Issue No: Vol. 175, No. 7 (2018)
  • Phase Separation, Protein Disorder, and Enhancer Function
    • Authors: Steven Hahn
      Pages: 1723 - 1725
      Abstract: New findings suggest that transcription enhancers work by recruitment of a large dynamic network of coactivators and other factors responsible for gene activation. Formation of these condensates is driven by DNA-bound transcription factors, their intrinsically disordered activation domains, and dynamic low-specificity interactions within the complex.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.034
      Issue No: Vol. 175, No. 7 (2018)
  • N4-acetylation of Cytidine in mRNA by NAT10 Regulates Stability and
    • Authors: Dan Dominissini; Gideon Rechavi
      Pages: 1725 - 1727
      Abstract: Arango et al. expand the repertoire of epitranscriptomic modifications by identifying N4-acetylcytidine in mRNA catalyzed by the known dual acetyltransferase NAT10. It occurs mainly in the coding sequence, likely in wobble positions of select codons, where it promotes stability and translation, possibly by safeguarding cognate codon-anticodon interaction.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.037
      Issue No: Vol. 175, No. 7 (2018)
  • Deception through Mimicry: A Cellular Antiviral Strategy
    • Authors: Nicholas C. Wu; Andrew B. Ward
      Pages: 1728 - 1729
      Abstract: Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach' Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.033
      Issue No: Vol. 175, No. 7 (2018)
  • Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
    • Authors: Hyeonwoo Kim; Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman
      Pages: 1756 - 1768.e17
      Abstract: Irisin, through its integrin receptor, promotes skeletal remodeling with implications for stemming bone loss.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      Issue No: Vol. 175, No. 7 (2018)
  • Multisensory Logic of Infant-Directed Aggression by Males
    • Authors: Yoh Isogai; Zheng Wu, Michael I. Love, Michael Ho-Young Ahn, Dhananjay Bambah-Mukku, Vivian Hua, Karolina Farrell, Catherine Dulac
      Pages: 1827 - 1841.e17
      Abstract: Physical features and chemical cues of mouse infants trigger virgin male aggression.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.032
      Issue No: Vol. 175, No. 7 (2018)
  • Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse
    • Authors: Jiaqiang Wang; Leyun Wang, Guihai Feng, Yukai Wang, Yufei Li, Xin Li, Chao Liu, Guanyi Jiao, Cheng Huang, Junchao Shi, Tong Zhou, Qi Chen, Zhonghua Liu, Wei Li, Qi Zhou
      Pages: 1887 - 1901.e18
      Abstract: An endogenous retrovirus-associated nuclear long noncoding RNA biases cell fate in mouse two-cell embryos.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.039
      Issue No: Vol. 175, No. 7 (2018)
  • CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development
    • Authors: Anna Hupalowska; Agnieszka Jedrusik, Meng Zhu, Mark T. Bedford, David M. Glover, Magdalena Zernicka-Goetz
      Pages: 1902 - 1916.e13
      Abstract: The association of the methyltransferase CARM1 with paraspeckles in 2- to 4-cell stage mouse embryos impacts proper lineage allocation and pre-implantation development.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.027
      Issue No: Vol. 175, No. 7 (2018)
  • Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of
           Ebola Virus Replication
    • Authors: Jyoti Batra; Judd F. Hultquist, Dandan Liu, Olena Shtanko, John Von Dollen, Laura Satkamp, Gwendolyn M. Jang, Priya Luthra, Toni M. Schwarz, Gabriel I. Small, Eusondia Arnett, Manu Anantpadma, Ann Reyes, Daisy W. Leung, Robyn Kaake, Paige Haas, Carson B. Schmidt, Larry S. Schlesinger, Douglas J. LaCount, Robert A. Davey, Gaya K. Amarasinghe, Christopher F. Basler, Nevan J. Krogan
      Pages: 1917 - 1930.e13
      Abstract: A host-Ebola protein-protein interaction map identifies candidate drug targets, including a host ubiquitin ligase that prevents viral replication, peptide mimics of which strongly inhibit Ebola replication in multiple cell types.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.08.044
      Issue No: Vol. 175, No. 7 (2018)
  • Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms
           of Dengue and Zika Virus Pathogenesis
    • Authors: Priya S. Shah; Nichole Link, Gwendolyn M. Jang, Phillip P. Sharp, Tongtong Zhu, Danielle L. Swaney, Jeffrey R. Johnson, John Von Dollen, Holly R. Ramage, Laura Satkamp, Billy Newton, Ruth Hüttenhain, Marine J. Petit, Tierney Baum, Amanda Everitt, Orly Laufman, Michel Tassetto, Michael Shales, Erica Stevenson, Gabriel N. Iglesias, Leila Shokat, Shashank Tripathi, Vinod Balasubramaniam, Laurence G. Webb, Sebastian Aguirre, A. Jeremy Willsey, Adolfo Garcia-Sastre, Katherine S. Pollard, Sara Cherry, Andrea V. Gamarnik, Ivan Marazzi, Jack Taunton, Ana Fernandez-Sesma, Hugo J. Bellen, Raul Andino, Nevan J. Krogan
      Pages: 1931 - 1945.e18
      Abstract: Comparing protein-protein interactions across dengue and Zika viruses reveals both common mechanisms and functionally distinct pathways contributing to infection outcomes.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.028
      Issue No: Vol. 175, No. 7 (2018)
  • Organoid Modeling of the Tumor Immune Microenvironment
    • Authors: James T. Neal; Xingnan Li, Junjie Zhu, Valeria Giangarra, Caitlin L. Grzeskowiak, Jihang Ju, Iris H. Liu, Shin-Heng Chiou, Ameen A. Salahudeen, Amber R. Smith, Brian C. Deutsch, Lillian Liao, Allison J. Zemek, Fan Zhao, Kasper Karlsson, Liora M. Schultz, Thomas J. Metzner, Lincoln D. Nadauld, Yuen-Yi Tseng, Sahar Alkhairy, Coyin Oh, Paula Keskula, Daniel Mendoza-Villanueva, Francisco M. De La Vega, Pamela L. Kunz, Joseph C. Liao, John T. Leppert, John B. Sunwoo, Chiara Sabatti, Jesse S. Boehm, William C. Hahn, Grace X.Y. Zheng, Mark M. Davis, Calvin J. Kuo
      Pages: 1972 - 1988.e16
      Abstract: The tumor-immune microenvironment is modeled using a patient-derived organoid approach that preserves the original tumor T cell receptor spectrum and successfully models immune checkpoint blockade.
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.021
      Issue No: Vol. 175, No. 7 (2018)
  • Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance
           to a Rapid Environmental Change
    • Authors: Jeffrey N. Carey; Erin L. Mettert, Manuela Roggiani, Kevin S. Myers, Patricia J. Kiley, Mark Goulian
      Pages: 1989 - 1990
      Abstract: (Cell 173, 196–207.e1–e14; March 22, 2018)
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.051
      Issue No: Vol. 175, No. 7 (2018)
  • Evolutionary Pressure against MHC Class II Binding Cancer Mutations
    • Authors: Rachel Marty Pyke; Wesley Kurt Thompson, Rany M. Salem, Joan Font-Burgada, Maurizio Zanetti, Hannah Carter
      First page: 1991
      Abstract: (Cell 175, 416–428.e1–e13; October 4, 2018)
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.050
      Issue No: Vol. 175, No. 7 (2018)
  • Retraction Notice to: Crystal Structure of a Complement Control Protein
           that Regulates Both Pathways of Complement Activation and Binds Heparan
           Sulfate Proteoglycans
    • Authors: Krishna H.M. Murthy; Scott A. Smith, Vannakambadi K. Ganesh, Ken W. Judge, Nick Mullin, Paul N. Barlow, Craig M. Ogata, Girish J. Kotwal
      First page: 1992
      Abstract: (Cell 104, 301–311; January 26, 2001)
      Citation: Cell 175, 7 (2018)
      PubDate: 2018-12-13
      DOI: 10.1016/j.cell.2018.11.047
      Issue No: Vol. 175, No. 7 (2018)
  • A Host-Produced Quorum-Sensing Autoinducer Controls a Phage Lysis-Lysogeny
    • Authors: Justin E. Silpe; Bonnie L. Bassler
      Abstract: Bacteriophages can “listen in” on their host bacterium’s quorum-sensing systems, shifting their lysis-lysogeny decisions based on host cell density.
      Citation: Cell (2018)
      PubDate: 2018-12-13
  • Emergence and Spread of Basal Lineages of Yersinia pestis during the
           Neolithic Decline
    • Authors: Nicolás Rascovan; Karl-Göran Sjögren, Kristian Kristiansen, Rasmus Nielsen, Eske Willerslev, Christelle Desnues, Simon Rasmussen
      Abstract: The genome of an ancient strain of Yersinia pestis from Neolithic farmers 4,900 years ago represents the oldest discovered case of the plague and allows characterization of the spread and diversification of multiple basal lineages, potentially contributing to the Neolithic decline.
      Citation: Cell (2018)
      PubDate: 2018-12-06
      DOI: 10.1016/j.cell.2018.11.005
  • The Human RNA-Binding Proteome and Its Dynamics during Translational
    • Authors: Jakob Trendel; Thomas Schwarzl, Rastislav Horos, Ananth Prakash, Alex Bateman, Matthias W. Hentze, Jeroen Krijgsveld
      Abstract: A general approach for characterizing cellular RNA-protein interactions allows examination of dynamic changes to the RNA-bound proteome.
      Citation: Cell (2018)
      PubDate: 2018-12-06
      DOI: 10.1016/j.cell.2018.11.004
  • Engineering Epigenetic Regulation Using Synthetic Read-Write Modules
    • Authors: Minhee Park; Nikit Patel, Albert J. Keung, Ahmad S. Khalil
      Abstract: A synthetic, modular, and programmable read-write system allows isolated and orthogonal epigenetic control in mammalian cells.
      Citation: Cell (2018)
      PubDate: 2018-12-06
      DOI: 10.1016/j.cell.2018.11.002
  • Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that
           Underlies Chemotherapy-Related Cognitive Impairment
    • Authors: Erin M. Gibson; Surya Nagaraja, Alfonso Ocampo, Lydia T. Tam, Lauren S. Wood, Praveen N. Pallegar, Jacob J. Greene, Anna C. Geraghty, Andrea K. Goldstein, Lijun Ni, Pamelyn J. Woo, Ben A. Barres, Shane Liddelow, Hannes Vogel, Michelle Monje
      Abstract: Microglial activation by methotrexate leads to a persistent disruption of oligodendrocyte lineage dynamics and astrocyte reactivity, resulting in the long-term cognitive impairment associated with chemotherapy.
      Citation: Cell (2018)
      PubDate: 2018-12-06
  • Low-Fidelity Assembly of Influenza A Virus Promotes Escape from Host Cells
    • Authors: Michael D. Vahey; Daniel A. Fletcher
      Abstract: Live imaging of influenza A viral particles demonstrates that virion protein composition and morphology varies widely within the population produced by a single infected cell, suggesting that stochastic viral assembly may mediate phenotypic diversity and viral adaptation.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to
           Regulate Transcription
    • Authors: Amar N. Mirza; Siegen A. McKellar, Nicole M. Urman, Alexander S. Brown, Tyler Hollmig, Sumaira Z. Aasi, Anthony E. Oro
      Abstract: A nuclear chaperoning system regulates movement of the transcription factor GLI1 between the nuclear lamina and nucleoplasm to achieve maximal activation.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of
           Co-transcriptional Interference
    • Authors: Lilan You; Jun Ma, Jiuyu Wang, Daria Artamonova, Min Wang, Liang Liu, Hua Xiang, Konstantin Severinov, Xinzheng Zhang, Yanli Wang
      Abstract: Structures of the type III-A CRISPR-Csm complex in the presence of target RNAs reveal the molecular basis for a unique mode of self/non-self discrimination.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Beta-Arrestin1 Prevents Preeclampsia by Downregulation of Mechanosensitive
           AT1-B2 Receptor Heteromers
    • Authors: Ursula Quitterer; Xuebin Fu, Armin Pohl, Karam M. Bayoumy, Andreas Langer, Said AbdAlla
      Abstract: This paper provides a mechanistic understanding of the causes of preeclampsia and uses the newly gained insights to explore treatment for the condition.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing
    • Authors: Federico Rojas; Eleanor Silvester, Julie Young, Rachel Milne, Mabel Tettey, Douglas R. Houston, Malcolm D. Walkinshaw, Irene Pérez-Pi, Manfred Auer, Helen Denton, Terry K. Smith, Joanne Thompson, Keith R. Matthews
      Abstract: The trypanosome “stumpy” form, important for parasite transmissibility and controlling virulence, is induced by paracrine oligopeptide signaling via an orphan G protein-coupled receptor-related protein functioning as a peptide transporter.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity
           by Unleashing Both T and NK Cells
    • Authors: Pascale André; Caroline Denis, Caroline Soulas, Clarisse Bourbon-Caillet, Julie Lopez, Thomas Arnoux, Mathieu Bléry, Cécile Bonnafous, Laurent Gauthier, Ariane Morel, Benjamin Rossi, Romain Remark, Violette Breso, Elodie Bonnet, Guillaume Habif, Sophie Guia, Ana Ines Lalanne, Caroline Hoffmann, Olivier Lantz, Jérôme Fayette, Agnès Boyer-Chammard, Robert Zerbib, Pierre Dodion, Hormas Ghadially, Maria Jure-Kunkel, Yannis Morel, Ronald Herbst, Emilie Narni-Mancinelli, Roger B. Cohen, Eric Vivier
      First page: 1731
      Abstract: Blocking of the NKG2A inhibitory receptor unleashes both T and NK cells, and demonstrates anti-tumor efficacy in combination with anti-EGFR or with anti-PD-x antibodies.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer
    • Authors: Nadine van Montfoort; Linda Borst, Michael J. Korrer, Marjolein Sluijter, Koen A. Marijt, Saskia J. Santegoets, Vanessa J. van Ham, Ilina Ehsan, Pornpimol Charoentong, Pascale André, Nicolai Wagtmann, Marij J.P. Welters, Young J. Kim, Sytse J. Piersma, Sjoerd H. van der Burg, Thorbald van Hall
      First page: 1744
      Abstract: Blocking the function of the NKG2A inhibitory receptor, as well as its ligand, promotes robust anti-tumor immunity in a number of animal tumor models, including one refractory to PD-1 blockade.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Cell Membranes Resist Flow
    • Authors: Zheng Shi; Zachary T. Graber, Tobias Baumgart, Howard A. Stone, Adam E. Cohen
      First page: 1769
      Abstract: Changes in membrane tension do not spread over long distances in plasma membranes, which has implications for how mechanical stimuli are sensed and propagated in cells.
      Citation: Cell (2018)
      PubDate: 2018-11-01
      DOI: 10.1016/j.cell.2018.09.054
  • Distinct Regulation of Th17 and Th1 Cell Differentiation by
           Glutaminase-Dependent Metabolism
    • Authors: Marc O. Johnson; Melissa M. Wolf, Matthew Z. Madden, Gabriela Andrejeva, Ayaka Sugiura, Diana C. Contreras, Damian Maseda, Maria V. Liberti, Katelyn Paz, Rigel J. Kishton, Matthew E. Johnson, Aguirre A. de Cubas, Pingsheng Wu, Gongbo Li, Yongliang Zhang, Dawn C. Newcomb, Andrew D. Wells, Nicholas P. Restifo, W. Kimryn Rathmell, Jason W. Locasale, Marco L. Davila, Bruce R. Blazar, Jeffrey C. Rathmell
      First page: 1780
      Abstract: Glutamine metabolism, and its effects on chromatin, promotes Th17 but constrains Th1 and CTL effector cell differentiation.
      Citation: Cell (2018)
      PubDate: 2018-11-01
  • Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through
           Haplotype Editing
    • Authors: Valentina Lo Sardo; Pavel Chubukov, William Ferguson, Aditya Kumar, Evan L. Teng, Michael Duran, Lei Zhang, Gregory Cost, Adam J. Engler, Fyodor Urnov, Eric J. Topol, Ali Torkamani, Kristin K. Baldwin
      First page: 1796
      Abstract: Genome editing and iPSC-based modeling of the 9p21.3 cardiovascular disease locus shows that it controls large gene networks acting in vascular smooth muscle cells that predispose them to assume atherogenic-like cell states.
      Citation: Cell ()
      PubDate: 2018-12-06
      DOI: 10.1016/j.cell.2018.11.014
  • Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed
           Cell Death through the TFEB-PUMA Axis
    • Authors: Lu O. Sun; Sara B. Mulinyawe, Hannah Y. Collins, Adiljan Ibrahim, Qingyun Li, David J. Simon, Marc Tessier-Lavigne, Ben A. Barres
      First page: 1811
      Abstract: Programmed cell death actively eliminates oligodendrocytes in non-myelinated brain regions to ensure region-specific myelination. Transcription factor EB activates the PUMA-Bax-Bak pathway to promote programmed cell death of subsets of premyelinating oligodendrocytes, allowing temporal and regional specificity of CNS myelination.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Transcription Factors Activate Genes through the Phase-Separation Capacity
           of Their Activation Domains
    • Authors: Ann Boija; Isaac A. Klein, Benjamin R. Sabari, Alessandra Dall’Agnese, Eliot L. Coffey, Alicia V. Zamudio, Charles H. Li, Krishna Shrinivas, John C. Manteiga, Nancy M. Hannett, Brian J. Abraham, Lena K. Afeyan, Yang E. Guo, Jenna K. Rimel, Charli B. Fant, Jurian Schuijers, Tong Ihn Lee, Dylan J. Taatjes, Richard A. Young
      First page: 1842
      Abstract: Activation domains from a diverse array of mammalian and yeast transcription factors form phase-separated condensates with Mediator to activate gene expression.
      Citation: Cell (2018)
      PubDate: 2018-11-15
  • Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting
           of the Endonuclease Activity
    • Authors: Stefano Stella; Pablo Mesa, Johannes Thomsen, Bijoya Paul, Pablo Alcón, Simon B. Jensen, Bhargav Saligram, Matias E. Moses, Nikos S. Hatzakis, Guillermo Montoya
      First page: 1856
      Abstract: The cryo-EM structures of Cas12a and smFRET reveal the activation mechanism for target DNA cleavage and indiscriminate ssDNA degradation. The displacement of the R-loop by crRNA suggests a mechanism to stop unspecific ssDNA degradation, resetting the endonuclease to target a new DNA sequence.
      Citation: Cell (2018)
      PubDate: 2018-11-29
  • Acetylation of Cytidine in mRNA Promotes Translation Efficiency
    • Authors: Daniel Arango; David Sturgill, Najwa Alhusaini, Allissa A. Dillman, Thomas J. Sweet, Gavin Hanson, Masaki Hosogane, Wilson R. Sinclair, Kyster K. Nanan, Mariana D. Mandler, Stephen D. Fox, Thomas T. Zengeya, Thorkell Andresson, Jordan L. Meier, Jeffery Coller, Shalini Oberdoerffer
      First page: 1872
      Abstract: Post-transcriptional acetylation of cytidines in mammalian mRNAs enhances RNA stability and translation.
      Citation: Cell (2018)
      PubDate: 2018-11-15
  • Scalable, Continuous Evolution of Genes at Mutation Rates above Genomic
           Error Thresholds
    • Authors: Arjun Ravikumar; Garri A. Arzumanyan, Muaeen K.A. Obadi, Alex A. Javanpour, Chang C. Liu
      First page: 1946
      Abstract: An orthogonal DNA replication system with high mutagenicity allows for continuous directed evolution and investigation into experimental evolutionary trajectories, including the adaptive landscape of malarial drug resistance.
      Citation: Cell (2018)
      PubDate: 2018-11-08
  • Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators
           of Immune Function
    • Authors: Eric Shifrut; Julia Carnevale, Victoria Tobin, Theodore L. Roth, Jonathan M. Woo, Christina T. Bui, P. Jonathan Li, Morgan E. Diolaiti, Alan Ashworth, Alexander Marson
      First page: 1958
      Abstract: CRISPR screening in primary human T cells combined with RNA sequencing identifies regulators of T cell stimulation and suppression with implications for immunotherapy.
      Citation: Cell (2018)
      PubDate: 2018-11-15
  • Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression
    • Authors: Joseph Rodriguez; Gang Ren, Christopher R. Day, Keji Zhao, Carson C. Chow, Daniel R. Larson
      Abstract: Time-dependent dynamics of promoter-enhancer associations contribute to transcriptional noise and shape responses to ligand-dependent gene induction.
      Citation: Cell ()
      DOI: 10.1016/j.cell.2018.11.026
  • HMCES Maintains Genome Integrity by Shielding Abasic Sites in
           Single-Strand DNA
    • Authors: Kareem N. Mohni; Sarah R. Wessel, Runxiang Zhao, Andrea C. Wojciechowski, Jessica W. Luzwick, Hillary Layden, Brandt F. Eichman, Petria S. Thompson, Kavi P.M. Mehta, David Cortez
      Abstract: An enzyme conserved from bacteria to eukaryotes can covalently bind to abasic sites in single-stranded DNA to shield them and prevent genomic instability.
      Citation: Cell ()
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