Journal Cover
Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1251  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3148 journals]
  • Science that Inspires
    • Authors: The Cell Press Team
      Pages: 209 - 210
      Abstract: Science is evolving, and Cell Press is evolving too. You may have already noticed some of our growth and development, but this month we are moving into a new phase by rolling out the first elements of a new look for all of Cell Press. We have a new logo, a new color scheme that is unified across all that we do, and an underlying ethos that looks to the future of science and its role in society. We are a broader and more diverse organization than we used to be, with coverage across many scientific disciplines, and we have reached a point in our evolution where this type of external change is overdue.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2020.01.004
      Issue No: Vol. 180, No. 2 (2020)
       
  • A Therapy for Most with Cystic Fibrosis
    • Authors: Christine E. Bear
      First page: 211
      Abstract: TRIKAFTA is the third drug approved by the FDA that rescues defects caused by the major mutation F508del. It is superior to its predecessors that were approved for patients who are homozygous for F508del because TRIKAFTA is also effective in CF patients who harbor only one copy of this mutation.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.032
      Issue No: Vol. 180, No. 2 (2020)
       
  • Sperm Go to (Transcription) Extremes
    • Authors: Bluma J. Lesch
      Pages: 212 - 213
      Abstract: Xia and colleagues show that heritable mutations are kept in check in the male germline partly by ‘transcriptional scanning,” wherein the majority of genes are transcribed and therefore subject to transcription-coupled repair. They provide a new model for understanding the mechanisms of genome surveillance and evolution.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.033
      Issue No: Vol. 180, No. 2 (2020)
       
  • An IRON-clad Connection between Aging Organelles
    • Authors: Hongying Shen
      Pages: 214 - 216
      Abstract: Lysosome (vacuole) and mitochondria decline interdependently during aging through an unclear mechanism. In this issue of Cell, Hughes et al. (2020) show that defective vacuole-mediated cysteine compartmentalization in aging yeast leads to iron limitation and mitochondrial dysfunction.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.037
      Issue No: Vol. 180, No. 2 (2020)
       
  • A Single Transcription Factor Drives Toxoplasma gondii Differentiation
    • Authors: Joshua A. Kochanowsky; Anita A. Koshy
      Pages: 216 - 218
      Abstract: Microbes that cause persistent infections (e.g., herpes viruses) do so by switching from fast-growing lytic states to slow-growing latent states. Waldman et al. have identified a single transcription factor that governs the switch between the lytic and latent forms of Toxoplasma gondii, a parasite that causes a persistent brain infection.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.038
      Issue No: Vol. 180, No. 2 (2020)
       
  • Bacteriophage Prevents Alcoholic Liver Disease
    • Authors: Melis Çolakoğlu; Jing Xue, Mirko Trajkovski
      Pages: 218 - 220
      Abstract: Alcoholic hepatitis is a severe alcohol-associated liver disease with minimal treatment options. A recent study by Duan et al. uncovers that the exotoxin-secreting gut bacterium Enterococcus faecalis is a critical contributor to alcoholic hepatitis. This bacterium can now be eliminated with a bacteriophage, suggesting a new way to treat this life-threatening disease.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.034
      Issue No: Vol. 180, No. 2 (2020)
       
  • Establishing or Exaggerating Causality for the Gut Microbiome: Lessons
           from Human Microbiota-Associated Rodents
    • Authors: Jens Walter; Anissa M. Armet, B. Brett Finlay, Fergus Shanahan
      Pages: 221 - 232
      Abstract: Walter and colleagues argue that human-microbiota-associated rodent experiments are generally overinterpreted and misused. In this Perspective, they provide a framework for improving the rigor of these gold-standard experiments to sort out truly causal microbiome-disease relationships.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.025
      Issue No: Vol. 180, No. 2 (2020)
       
  • Snake Venom Gland Organoids
    • Authors: Yorick Post; Jens Puschhof, Joep Beumer, Harald M. Kerkkamp, Merijn A.G. de Bakker, Julien Slagboom, Buys de Barbanson, Nienke R. Wevers, Xandor M. Spijkers, Thomas Olivier, Taline D. Kazandjian, Stuart Ainsworth, Carmen Lopez Iglesias, Willine J. van de Wetering, Maria C. Heinz, Ravian L. van Ineveld, Regina G.D.M. van Kleef, Harry Begthel, Jeroen Korving, Yotam E. Bar-Ephraim, Walter Getreuer, Anne C. Rios, Remco H.S. Westerink, Hugo J.G. Snippert, Alexander van Oudenaarden, Peter J. Peters, Freek J. Vonk, Jeroen Kool, Michael K. Richardson, Nicholas R. Casewell, Hans Clevers
      Pages: 233 - 247.e21
      Abstract: The establishment of venom gland organoids from a variety of snake species allows for the production and harvest of different types of toxins of biological interest.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.11.038
      Issue No: Vol. 180, No. 2 (2020)
       
  • Widespread Transcriptional Scanning in the Testis Modulates Gene Evolution
           Rates
    • Authors: Bo Xia; Yun Yan, Maayan Baron, Florian Wagner, Dalia Barkley, Marta Chiodin, Sang Y. Kim, David L. Keefe, Joseph P. Alukal, Jef D. Boeke, Itai Yanai
      Pages: 248 - 262.e21
      Abstract: The male germline cells in human and mice balance the protection of genomic integrity and the evolutionary benefit of genetic mutations through transcriptional scanning, a mechanism that preferentially couples efficient DNA damage repair with high transcription activity.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.015
      Issue No: Vol. 180, No. 2 (2020)
       
  • Evolutionary Persistence of DNA Methylation for Millions of Years after
           Ancient Loss of a De Novo Methyltransferase
    • Authors: Sandra Catania; Phillip A. Dumesic, Harold Pimentel, Ammar Nasif, Caitlin I. Stoddard, Jordan E. Burke, Jolene K. Diedrich, Sophie Cook, Terrance Shea, Elizabeth Geinger, Robert Lintner, John R. Yates, Petra Hajkova, Geeta J. Narlikar, Christina A. Cuomo, Jonathan K. Pritchard, Hiten D. Madhani
      Pages: 263 - 277.e20
      Abstract: The pathogenic fungus Cryptococcus neoformans encodes a functional maintenance methyltransferase for 5mC but no de novo enzyme; 5mC has been maintained for millions of years by a combintation of random epimutation and natural selection.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-16
      DOI: 10.1016/j.cell.2019.12.012
      Issue No: Vol. 180, No. 2 (2020)
       
  • FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide
           Cycle
    • Authors: M. Zaeem Cader; Rodrigo Pereira de Almeida Rodrigues, James A. West, Gavin W. Sewell, Muhammad N. Md-Ibrahim, Stephanie Reikine, Giuseppe Sirago, Lukas W. Unger, Ana Belén Inglesias-Romero, Katharina Ramshorn, Lea-Maxie Haag, Svetlana Saveljeva, Jana-Fabienne Ebel, Philip Rosenstiel, Nicole C. Kaneider, James C. Lee, Trevor D. Lawley, Allan Bradley, Gordon Dougan, Yorgo Modis, Julian L. Griffin, Arthur Kaser
      Pages: 278 - 295.e23
      Abstract: Disease-linked, orphan FAMIN is an evolutionarily conserved, multifunctional purine nucleoside enzyme, with not only ADA-, PNP-, and MTAP-like activities but also adenosine phosphorylase activity. FAMIN enables a purine nucleotide cycle that balances the cytoplasmic-mitochondrial redox interface and prevents cytoplasmic acidification.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.017
      Issue No: Vol. 180, No. 2 (2020)
       
  • Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering
           Iron Homeostasis
    • Authors: Casey E. Hughes; Troy K. Coody, Mi-Young Jeong, Jordan A. Berg, Dennis R. Winge, Adam L. Hughes
      Pages: 296 - 310.e18
      Abstract: Breakdown of the spatial compartmentalization of amino acids by vacuoles is a key driver of age-related mitochondrial deterioration through ROS-dependent perturbation of iron homeostasis.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.035
      Issue No: Vol. 180, No. 2 (2020)
       
  • Structural Basis of Teneurin-Latrophilin Interaction in Repulsive Guidance
           of Migrating Neurons
    • Authors: Daniel del Toro; Maria A. Carrasquero-Ordaz, Amy Chu, Tobias Ruff, Meriam Shahin, Verity A. Jackson, Matthieu Chavent, Miguel Berbeira-Santana, Goenuel Seyit-Bremer, Sara Brignani, Rainer Kaufmann, Edward Lowe, Rüdiger Klein, Elena Seiradake
      Pages: 323 - 339.e19
      Abstract: 3D structures reveal how Latrophilin binds across the Teneurin protein and enable modeling of simultaneous FLRT binding. del Toro et al. show that this trimeric complex is important not only during synapse formation but also in earlier stages of development, where it guides the migration of young neurons by providing repulsive signals.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-09
      DOI: 10.1016/j.cell.2019.12.014
      Issue No: Vol. 180, No. 2 (2020)
       
  • Identification of a Master Regulator of Differentiation in Toxoplasma
    • Authors: Benjamin S. Waldman; Dominic Schwarz, Marc H. Wadsworth, Jeroen P. Saeij, Alex K. Shalek, Sebastian Lourido
      Pages: 359 - 372.e16
      Abstract: A single parasite transcription factor drives the differentiation of Toxoplasma to a cyst-forming stage to sustain chronic infection.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-16
      DOI: 10.1016/j.cell.2019.12.013
      Issue No: Vol. 180, No. 2 (2020)
       
  • Cell-Surface Proteomic Profiling in the Fly Brain Uncovers Wiring
           Regulators
    • Authors: Jiefu Li; Shuo Han, Hongjie Li, Namrata D. Udeshi, Tanya Svinkina, D.R. Mani, Chuanyun Xu, Ricardo Guajardo, Qijing Xie, Tongchao Li, David J. Luginbuhl, Bing Wu, Colleen N. McLaughlin, Anthony Xie, Pornchai Kaewsapsak, Stephen R. Quake, Steven A. Carr, Alice Y. Ting, Liqun Luo
      Pages: 373 - 386.e15
      Abstract: In situ cell-surface proteomic profiling of developing and mature olfactory projection neurons uncovers the temporal evolution of the neuronal surface landscape in development and reveals many new neural wiring molecules belonging to evolutionarily conserved but previously unexpected molecular families.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-16
      DOI: 10.1016/j.cell.2019.12.029
      Issue No: Vol. 180, No. 2 (2020)
       
  • Quantitative Proteomics of the Cancer Cell Line Encyclopedia
    • Authors: David P. Nusinow; John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald, Marian Kalocsay, Judit Jané-Valbuena, Ellen Gelfand, Devin K. Schweppe, Mark Jedrychowski, Javad Golji, Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi A. Garraway, William R. Sellers, Steven P. Gygi
      Pages: 387 - 402.e16
      Abstract: Quantitative proteomes of 375 cancer cell lines for the Cancer Cell Line Encyclopedia (CCLE) reveal correlated protein expression between multiple pathways and complexes as well as associations between protein complexes and genetic features including microsatellite instability, individual gene mutations, and sensitivity to gene knockdowns.
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2019.12.023
      Issue No: Vol. 180, No. 2 (2020)
       
  • Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis
           Risk
    • Authors: International Multiple Sclerosis Genetics Consortium
      First page: 403
      Abstract: (Cell 175, 1679–1687.e1–e7; November 29, 2018)
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2020.01.002
      Issue No: Vol. 180, No. 2 (2020)
       
  • Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity
           Threshold
    • Authors: David W. Vredevoogd; Thomas Kuilman, Maarten A. Ligtenberg, Julia Boshuizen, Kelly E. Stecker, Beaunelle de Bruijn, Oscar Krijgsman, Xinyao Huang, Juliana C.N. Kenski, Ruben Lacroix, Riccardo Mezzadra, Raquel Gomez-Eerland, Mete Yildiz, Ilknur Dagidir, Georgi Apriamashvili, Nordin Zandhuis, Vincent van der Noort, Nils L. Visser, Christian U. Blank, Maarten Altelaar, Ton N. Schumacher, Daniel S. Peeper
      Pages: 404 - 405
      Abstract: (Cell 178, 585–599.e1–e15; July 25, 2019)
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2020.01.005
      Issue No: Vol. 180, No. 2 (2020)
       
  • An Allosteric Anti-tryptase Antibody for the Treatment of Mast
           Cell-Mediated Severe Asthma
    • Authors: Henry R. Maun; Janet K. Jackman, David F. Choy, Kelly M. Loyet, Tracy L. Staton, Guiquan Jia, Amy Dressen, Jason A. Hackney, Meire Bremer, Benjamin T. Walters, Rajesh Vij, Xiaocheng Chen, Neil N. Trivedi, Ashley Morando, Michael T. Lipari, Yvonne Franke, Xiumin Wu, Juan Zhang, John Liu, Ping Wu, Diana Chang, Luz D. Orozco, Erin Christensen, Manda Wong, Racquel Corpuz, Julie Q. Hang, Jeff Lutman, Siddharth Sukumaran, Yan Wu, Savita Ubhayakar, Xiaorong Liang, Lawrence B. Schwartz, Magda Babina, Prescott G. Woodruff, John V. Fahy, Rahul Ahuja, George H. Caughey, Aija Kusi, Mark S. Dennis, Charles Eigenbrot, Daniel Kirchhofer, Cary D. Austin, Lawren C. Wu, James T. Koerber, Wyne P. Lee, Brian L. Yaspan, Kathila R. Alatsis, Joseph R. Arron, Robert A. Lazarus, Tangsheng Yi
      First page: 406
      Abstract: (Cell 179, 417–431.e1–e19; October 3, 2019)
      Citation: Cell 180, 2 (2020)
      PubDate: 2020-01-23
      DOI: 10.1016/j.cell.2020.01.003
      Issue No: Vol. 180, No. 2 (2020)
       
  • Saltatory Conduction along Myelinated Axons Involves a Periaxonal
           Nanocircuit
    • Authors: Charles C.H. Cohen; Marko A. Popovic, Jan Klooster, Marie-Theres Weil, Wiebke Möbius, Klaus-Armin Nave, Maarten H.P. Kole
      Pages: 311 - 322.e15
      Abstract: Patch-clamp recording and computational modeling combined with high-speed voltage-calibrated optical recordings and EM analysis reveal a second longitudinal conducting pathway formed by the periaxonal and paranodal submyelin spaces that are integral to reproducing the spatiotemporal profile of action potential saltation.
      Citation: Cell 180, 2 (2020)
      PubDate: 2019-12-26
      DOI: 10.1016/j.cell.2019.11.039
      Issue No: Vol. 180, No. 2 (2019)
       
  • Structural Basis of Human KCNQ1 Modulation and Gating
    • Authors: Ji Sun; Roderick MacKinnon
      Pages: 340 - 347.e9
      Abstract: Cryo-EM structures of the human voltage-dependent potassium channel KCNQ1 in complex with its ancillary subunit KCNE3, in the presence or absence of the PIP2-activating co-factor, provide insight into how PIP2 binding leads to channel opening.
      Citation: Cell 180, 2 (2020)
      PubDate: 2019-12-26
      DOI: 10.1016/j.cell.2019.12.003
      Issue No: Vol. 180, No. 2 (2019)
       
  • In Situ Structure of an Intact Lipopolysaccharide-Bound Bacterial Surface
           Layer
    • Authors: Andriko von Kügelgen; Haiping Tang, Gail G. Hardy, Danguole Kureisaite-Ciziene, Yves V. Brun, Phillip J. Stansfeld, Carol V. Robinson, Tanmay A.M. Bharat
      Pages: 348 - 358.e15
      Abstract: Cryo-electron tomography allows structure determination of the bacterial S-layer in its cellular context at near-atomic resolution, providing insights into how it’s assembled and organized.
      Citation: Cell 180, 2 (2020)
      PubDate: 2019-12-26
      DOI: 10.1016/j.cell.2019.12.006
      Issue No: Vol. 180, No. 2 (2019)
       
 
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