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Journal Cover
Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 952  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3163 journals]
  • New Flavors in Immunomodulation
    • Authors: Jacques Deguine
      First page: 1553
      Abstract: Whether to boost the immune system or to tame it, drugs that modulate immune function are becoming an essential part of modern pharmacopoeia. While many of these target molecules that are expressed by immune cells, recent advances in immunometabolism are now opening new classes of modulators that derive from endogenous metabolites.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.049
      Issue No: Vol. 173, No. 7 (2018)
       
  • The Ongoing Shakeup in Organelle Biology
    • Pages: 1557 - 1559
      Abstract: With the complexities of organelle communication and their dynamics under intense investigation, what are the new principles that are emerging, and where is the field headed' Cell’s Robert Kruger recently discussed these questions with Erika Holzbaur, Jennifer Lippincott-Schwartz, and Ivan Dikic. Annotated excerpts from this conversation are presented below, and the full conversation is available with the article online.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.054
      Issue No: Vol. 173, No. 7 (2018)
       
  • CRISPR Inspirations
    • Pages: 1560 - 1561
      Abstract: A decade has passed since the publication by Barrangou et al. described CRISPR-Cas as a bacterial adaptive defense system, where the acquisition of short DNA pieces into the Streptococcus thermophilus chromosome guides immunity against foreign DNA. These findings galvanized the entire microbiology community at a time when I was starting my independent lab and prompted my dilemma whether to establish a new line of research based on this publication or to explore the safer, more established fields in which I had been trained.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.055
      Issue No: Vol. 173, No. 7 (2018)
       
  • Visible Machine Learning for Biomedicine
    • Authors: Michael K. Yu; Jianzhu Ma, Jasmin Fisher, Jason F. Kreisberg, Benjamin J. Raphael, Trey Ideker
      Pages: 1562 - 1565
      Abstract: A major ambition of artificial intelligence lies in translating patient data to successful therapies. Machine learning models face particular challenges in biomedicine, however, including handling of extreme data heterogeneity and lack of mechanistic insight into predictions. Here, we argue for “visible” approaches that guide model structure with experimental biology.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.056
      Issue No: Vol. 173, No. 7 (2018)
       
  • Prospecting for Planarian Pluripotency
    • Authors: Tania Rozario; Phillip A. Newmark
      Pages: 1566 - 1567
      Abstract: Planarians are renowned for extraordinary regenerative abilities that are driven by stem cells maintained throughout their lives. In this issue of Cell, Zeng et al. report the prospective isolation of planarian pluripotent stem cells. Their work opens new directions for understanding how these remarkable cells are established, maintained, and activated.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.062
      Issue No: Vol. 173, No. 7 (2018)
       
  • Disease Heritability Studies Harness the Healthcare System to Achieve
           Massive Scale
    • Authors: Joshua C. Denny; Jonathan D. Mosley
      Pages: 1568 - 1570
      Abstract: Heritability studies are essential for defining genetic influences on disease risk and trait variability. Polubriaginof et al. show how massive amounts of data contained in electronic health records can be used for heritability studies on hundreds of phenotypes. Mining emergency contact information with comparison to existing gold standards showcases the broad utility of the approach.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.053
      Issue No: Vol. 173, No. 7 (2018)
       
  • Sunlight Brightens Learning and Memory
    • Authors: Lynne Chantranupong; Bernardo L. Sabatini
      Pages: 1570 - 1572
      Abstract: Sunlight can alter mood, behavior, and cognition, but the cellular basis of this phenomenon remains to be fully elucidated. In this issue of Cell, Zhu et al. shed light on a UV-dependent metabolic pathway that leads to increased synaptic release of glutamate and enhanced motor learning and memory in mice.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.044
      Issue No: Vol. 173, No. 7 (2018)
       
  • Common Disease Is More Complex Than Implied by the Core Gene Omnigenic
           Model
    • Authors: Naomi R. Wray; Cisca Wijmenga, Patrick F. Sullivan, Jian Yang, Peter M. Visscher
      Pages: 1573 - 1580
      Abstract: Frameworks for understanding how genes contribute to phenotypic traits have the power to shape experimental approaches and funding allocations. In contrast to the recent “omnigenic” model that emphasized contributions from a few core genes to complex disease, this Perspective argues for continued support for acquiring a broad range of patient data to link genetic variation with phenotypic diversity.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.051
      Issue No: Vol. 173, No. 7 (2018)
       
  • Prospectively Isolated Tetraspanin+ Neoblasts Are Adult Pluripotent Stem
           Cells Underlying Planaria Regeneration
    • Authors: An Zeng; Hua Li, Longhua Guo, Xin Gao, Sean McKinney, Yongfu Wang, Zulin Yu, Jungeun Park, Craig Semerad, Eric Ross, Li-Chun Cheng, Erin Davies, Kai Lei, Wei Wang, Anoja Perera, Kate Hall, Allison Peak, Andrew Box, Alejandro Sánchez Alvarado
      Pages: 1593 - 1608.e20
      Abstract: Transplantation of a single pluripotent neoblast can restore regenerative ability and viability to lethally irradiated Planaria.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.006
      Issue No: Vol. 173, No. 7 (2018)
       
  • Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human
           Nuclear RNA Exosome-MTR4 Complex
    • Authors: Eva-Maria Weick; M. Rhyan Puno, Kurt Januszyk, John C. Zinder, Michael A. DiMattia, Christopher D. Lima
      Pages: 1663 - 1677.e21
      Abstract: The cryo-EM structure of the human nuclear exosome-Mtr4 complex loaded with an RNA substrate reveals mechanistic insights to how the helicase unwinds structured RNA substrates to promote degradation.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.041
      Issue No: Vol. 173, No. 7 (2018)
       
  • Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28
           Subphenotypes
    • Authors: Bipolar Disorder; Schizophrenia Working Group of the Psychiatric Genomics Consortium
      Pages: 1705 - 1715.e16
      Abstract: Genetic analysis of multiple bipolar disorder and schizophrenia cohorts reveals loci and polygenic risk scores that differentiate the clinical symptoms of these two highly correlated disorders.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.046
      Issue No: Vol. 173, No. 7 (2018)
       
  • Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut
           Microbiota
    • Authors: Carolina Tropini; Eli Lin Moss, Bryan Douglas Merrill, Katharine Michelle Ng, Steven Kyle Higginbottom, Ellen Pun Casavant, Carlos Gutierrez Gonzalez, Brayon Fremin, Donna Michelle Bouley, Joshua Eric Elias, Ami Siddharth Bhatt, Kerwyn Casey Huang, Justin Laine Sonnenburg
      Pages: 1742 - 1754.e17
      Abstract: Mild diarrhea caused by an over-the-counter laxative leads to long-term changes in the gut microbiome of mice.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.008
      Issue No: Vol. 173, No. 7 (2018)
       
  • Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced
           Prostate Cancer
    • Authors: Yi-Mi Wu; Marcin Cieślik, Robert J. Lonigro, Pankaj Vats, Melissa A. Reimers, Xuhong Cao, Yu Ning, Lisha Wang, Lakshmi P. Kunju, Navonil de Sarkar, Elisabeth I. Heath, Jonathan Chou, Felix Y. Feng, Peter S. Nelson, Johann S. de Bono, Weiping Zou, Bruce Montgomery, Ajjai Alva, PCF/SU2C International Prostate Cancer Dream Team, Dan R. Robinson, Arul M. Chinnaiyan
      Pages: 1770 - 1782.e14
      Abstract: Loss of both alleles of the CDK12 gene defines a molecular subtype of metastatic castration-resistant prostate cancer that is potentially targetable with immune checkpoint inhibitors.
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.04.034
      Issue No: Vol. 173, No. 7 (2018)
       
  • Mfd Dynamically Regulates Transcription via a Release and Catch-Up
           Mechanism
    • Authors: Tung T. Le; Yi Yang, Chuang Tan, Margaret M. Suhanovsky, Robert M. Fulbright, James T. Inman, Ming Li, Jaeyoon Lee, Sarah Perelman, Jeffrey W. Roberts, Alexandra M. Deaconescu, Michelle D. Wang
      First page: 1823
      Abstract: (Cell 172, 344–357.e1–e7; January 11, 2018)
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.06.002
      Issue No: Vol. 173, No. 7 (2018)
       
  • Universal Patterns of Selection in Cancer and Somatic Tissues
    • Authors: Iñigo Martincorena; Keiran M. Raine, Moritz Gerstung, Kevin J. Dawson, Kerstin Haase, Peter Van Loo, Helen Davies, Michael R. Stratton, Peter J. Campbell
      First page: 1823
      Abstract: (Cell 171, 1029–1041.e1–e15; November 16, 2017)
      Citation: Cell 173, 7 (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.06.001
      Issue No: Vol. 173, No. 7 (2018)
       
  • A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain
    • Authors: Kristofer Davie; Jasper Janssens, Duygu Koldere, Maxime De Waegeneer, Uli Pech, Łukasz Kreft, Sara Aibar, Samira Makhzami, Valerie Christiaens, Carmen Bravo González-Blas, Suresh Poovathingal, Gert Hulselmans, Katina I. Spanier, Thomas Moerman, Bram Vanspauwen, Sarah Geurs, Thierry Voet, Jeroen Lammertyn, Bernard Thienpont, Sha Liu, Nikos Konstantinides, Mark Fiers, Patrik Verstreken, Stein Aerts
      Abstract: A single-cell atlas of adult fly brains identifies the ensemble of neuronal and glial cell types and their dynamic changes during aging.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.057
       
  • A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding
           Driver in Advanced Prostate Cancer
    • Authors: David Y. Takeda; Sándor Spisák, Ji-Heui Seo, Connor Bell, Edward O’Connor, Keegan Korthauer, Dezső Ribli, István Csabai, Norbert Solymosi, Zoltán Szállási, David R. Stillman, Paloma Cejas, Xintao Qiu, Henry W. Long, Viktória Tisza, Pier Vitale Nuzzo, Mersedeh Rohanizadegan, Mark M. Pomerantz, William C. Hahn, Matthew L. Freedman
      Abstract: Activation and amplification of an enhancer upstream of the androgen receptor locus drives progression of metastatic castration-resistant prostate cancer.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.037
       
  • Structural Alterations Driving Castration-Resistant Prostate Cancer
           Revealed by Linked-Read Genome Sequencing
    • Authors: Srinivas R. Viswanathan; Gavin Ha, Andreas M. Hoff, Jeremiah A. Wala, Jian Carrot-Zhang, Christopher W. Whelan, Nicholas J. Haradhvala, Samuel S. Freeman, Sarah C. Reed, Justin Rhoades, Paz Polak, Michelle Cipicchio, Stephanie A. Wankowicz, Alicia Wong, Tushar Kamath, Zhenwei Zhang, Gregory J. Gydush, Denisse Rotem, PCF/SU2C International Prostate Cancer Dream Team, J. Christopher Love, Gad Getz, Stacey Gabriel, Cheng-Zhong Zhang, Scott M. Dehm, Peter S. Nelson, Eliezer M. Van Allen, Atish D. Choudhury, Viktor A. Adalsteinsson, Rameen Beroukhim, Mary-Ellen Taplin, Matthew Meyerson
      Abstract: Linked-read genome sequencing data from patients highlight that amplification of an enhancer upstream of the androgen receptor locus is a key feature of metastatic castration-resistant prostate cancer.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.036
       
  • Developmental Origin Governs CD8+ T Cell Fate Decisions during Infection
    • Authors: Norah L. Smith; Ravi K. Patel, Arnold Reynaldi, Jennifer K. Grenier, Jocelyn Wang, Neva B. Watson, Kito Nzingha, Kristel J. Yee Mon, Seth A. Peng, Andrew Grimson, Miles P. Davenport, Brian D. Rudd
      Abstract: The discovery of multiple sub-populations of naive T cells, distinguished by their developmental origin and molecular profiles prior to microbial challenge, explains the heterogeneity observed in memory and effector pools.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.029
       
  • Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during
           Tumorigenesis
    • Authors: Paul K. Ziegler; Julia Bollrath, Charles K. Pallangyo, Takaji Matsutani, Özge Canli, Tiago De Oliveira, Michaela A. Diamanti, Nina Müller, Jaba Gamrekelashvili, Tracy Putoczki, David Horst, Arun K. Mankan, Meryem G. Öner, Susanna Müller, Josef Müller-Höcker, Thomas Kirchner, Julia Slotta-Huspenina, M. Mark Taketo, Thomas Reinheckel, Stefan Dröse, Andrew C. Larner, Winfried S. Wels, Matthias Ernst, Tim F. Greten, Melek C. Arkan, Thomas Korn, Dagmar Wirth, Florian R. Greten
      Abstract: Enhanced mitophagy in intestinal epithelial cells promotes anti-tumor immunity through increasing lysosomal membrane permeabilization that augments MHC I presentation and CD8+ T cell activation.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.028
       
  • A Milieu Molecule for TGF-β Required for Microglia Function in the
           Nervous System
    • Authors: Yan Qin; Brian S. Garrison, Wenjiang Ma, Rui Wang, Aiping Jiang, Jing Li, Meeta Mistry, Roderick T. Bronson, Daria Santoro, Charlotte Franco, Daisy A. Robinton, Beth Stevens, Derrick J. Rossi, Chafen Lu, Timothy A. Springer
      Abstract: The cell-surface milieu molecule LRRC33 selectively modulates downstream signaling outcomes through direct association with the TGF-β ligand in specific cell types.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.027
       
  • Phenotypic Convergence: Distinct Transcription Factors Regulate Common
           Terminal Features
    • Authors: Nikolaos Konstantinides; Katarina Kapuralin, Chaimaa Fadil, Luendreo Barboza, Rahul Satija, Claude Desplan
      Abstract: A single-cell analysis of the fly optic lobe reveals extensive phenotypic convergence with different sets of transcription factors, promoting similar outcomes in different cell types.
      Citation: Cell (2018)
      PubDate: 2018-06-14
      DOI: 10.1016/j.cell.2018.05.021
       
  • Dynamics and Spatial Genomics of the Nascent Transcriptome by Intron
           seqFISH
    • Authors: Sheel Shah; Yodai Takei, Wen Zhou, Eric Lubeck, Jina Yun, Chee-Huat Linus Eng, Noushin Koulena, Christopher Cronin, Christoph Karp, Eric J. Liaw, Mina Amin, Long Cai
      Abstract: Development of intron seqFISH allows in situ profiling and visualization of nascent transcription at the single-cell level, revealing spatial and temporal features of nascent transcriptome.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.035
       
  • Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the
           Nucleus
    • Authors: Sofia A. Quinodoz; Noah Ollikainen, Barbara Tabak, Ali Palla, Jan Marten Schmidt, Elizabeth Detmar, Mason M. Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, Erik Aznauryan, Pamela Russell, Christine Cheng, Marko Jovanovic, Amy Chow, Long Cai, Patrick McDonel, Manuel Garber, Mitchell Guttman
      Abstract: SPRITE enables genome-wide detection of multiple simultaneously occurring higher-order DNA interactions within the nucleus and provides a global picture of inter-chromosomal spatial arrangement around nuclear bodies.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.024
       
  • A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain
    • Authors: Benjamin Kleaveland; Charlie Y. Shi, Joanna Stefano, David P. Bartel
      Abstract: Three different classes of noncoding RNA converge in a regulatory network whereby a long noncoding RNA represses a microRNA via target-directed microRNA degradation, which in turn enables the accumulation of a circular RNA in the mouse brain.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.022
       
  • A Flat BAR Protein Promotes Actin Polymerization at the Base of
           Clathrin-Coated Pits
    • Authors: Leonardo Almeida-Souza; Rene A.W. Frank, Javier García-Nafría, Adeline Colussi, Nushan Gunawardana, Christopher M. Johnson, Minmin Yu, Gillian Howard, Byron Andrews, Yvonne Vallis, Harvey T. McMahon
      Abstract: A flat BAR protein binds to the membrane surrounding clathrin-coated pits and promotes actin polymerization to aid endocytic vesicle maturation.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.020
       
  • A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal
           Remodeling
    • Authors: Christoph Schneider; Claire E. O’Leary, Jakob von Moltke, Hong-Erh Liang, Qi Yan Ang, Peter J. Turnbaugh, Sridhar Radhakrishnan, Michael Pellizzon, Averil Ma, Richard M. Locksley
      Abstract: Succinate produced by mutualistic colonizing protozoa activates a small intestinal tuft cell-ILC2 circuit, leading to adaptive remodeling that facilitates energy homeostasis and infection resistance in the host and a reproductive niche for the pathosymbiont.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.014
       
  • SMCHD1 Merges Chromosome Compartments and Assists Formation of
           Super-Structures on the Inactive X
    • Authors: Chen-Yu Wang; Teddy Jégu, Hsueh-Ping Chu, Hyun Jung Oh, Jeannie T. Lee
      Abstract: Mammalian X inactivation relies on stepwise folding of chromosome compartments.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.007
       
  • TCR Transgenic Mice Reveal Stepwise, Multi-site Acquisition of the
           Distinctive Fat-Treg Phenotype
    • Authors: Chaoran Li; Joanna R. DiSpirito, David Zemmour, Raul German Spallanzani, Wilson Kuswanto, Christophe Benoist, Diane Mathis
      Abstract: The accumulation of regulatory T cells in visceral adipose tissue is the result of molecular and microenvironmental cues that drive cellular activation in the spleen, egress from lymphoid tissues, and final diversification in adipose tissue.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.004
       
  • Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
    • Authors: Zandra E. Walton; Chirag H. Patel, Rebekah C. Brooks, Yongjun Yu, Arig Ibrahim-Hashim, Malini Riddle, Alessandra Porcu, Tianying Jiang, Brett L. Ecker, Feven Tameire, Constantinos Koumenis, Ashani T. Weeraratna, David K. Welsh, Robert Gillies, James C. Alwine, Lin Zhang, Jonathan D. Powell, Chi V. Dang
      Abstract: Acid drives the redistribution of lysosomes to cellular peripheries, thus separating lysosomal mTORC1 from its perinuclear activator RHEB and leading to a collapse of the circadian clock.
      Citation: Cell (2018)
      PubDate: 2018-05-31
      DOI: 10.1016/j.cell.2018.05.009
       
  • Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory
           Enhancement
    • Authors: Adar Adamsky; Adi Kol, Tirzah Kreisel, Adi Doron, Nofar Ozeri-Engelhard, Talia Melcer, Ron Refaeli, Henrike Horn, Limor Regev, Maya Groysman, Michael London, Inbal Goshen
      Abstract: Astrocyte activation in the hippocampus is sufficient to generate synaptic potentiation, enhance memory allocation, and improve cognitive performance beyond what can be achieved by elevating neuronal activity alone.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.05.002
       
  • An Activity Switch in Human Telomerase Based on RNA Conformation and
           Shaped by TCAB1
    • Authors: Lu Chen; Caitlin M. Roake, Adam Freund, Pedro J. Batista, Siqi Tian, Yi A. Yin, Chandresh R. Gajera, Shengda Lin, Byron Lee, Matthew F. Pech, Andrew S. Venteicher, Rhiju Das, Howard Y. Chang, Steven E. Artandi
      Abstract: The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.039
       
  • CTCF-Binding Elements Mediate Accessibility of RAG Substrates During
           Chromatin Scanning
    • Authors: Suvi Jain; Zhaoqing Ba, Yu Zhang, Hai-Qiang Dai, Frederick W. Alt
      Abstract: RAG endonuclease associated with a DJH recombination center is presented with upstream chromosomal VHs by a linear chromatin scanning process involving loop extrusion. During this process, VH-proximal CTCF looping factor binding elements mediate greatly increased interactions of their associated VHs with the DJH recombination center and, thereby, increase their accessibility for RAG cleavage and subsequent V(D)J recombination.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.035
       
  • Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the
           CBP/p300 Acetylome
    • Authors: Brian T. Weinert; Takeo Narita, Shankha Satpathy, Balaji Srinivasan, Bogi K. Hansen, Christian Schölz, William B. Hamilton, Beth E. Zucconi, Wesley W. Wang, Wenshe R. Liu, Joshua M. Brickman, Edward A. Kesicki, Albert Lai, Kenneth D. Bromberg, Philip A. Cole, Chunaram Choudhary
      Abstract: A comprehensive look at CBP/p300 acetylation reveals dynamic changes that shape the regulation of protein function and gene expression.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.033
       
  • Structural Basis of Smoothened Activation in Hedgehog Signaling
    • Authors: Pengxiang Huang; Sanduo Zheng, Bradley M. Wierbowski, Youngchang Kim, Daniel Nedelcu, Laura Aravena, Jing Liu, Andrew C. Kruse, Adrian Salic
      Abstract: Crystal structures of sterol-bound Smoothened molecules reveal active conformations reminiscent of other classes of G-protein-coupled receptors.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.029
       
  • The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection
    • Authors: Jeffrey E. Markowitz; Winthrop F. Gillis, Celia C. Beron, Shay Q. Neufeld, Keiramarie Robertson, Neha D. Bhagat, Ralph E. Peterson, Emalee Peterson, Minsuk Hyun, Scott W. Linderman, Bernardo L. Sabatini, Sandeep Robert Datta
      Abstract: The striatum concatenates sub-second 3D behavioral motifs into action sequences during naturalistic behaviors.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.019
       
  • PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A)
           RNAs
    • Authors: Xing Liu; Rui Fu, Youdong Pan, Karla F. Meza-Sosa, Zhibin Zhang, Judy Lieberman
      Abstract: Widespread RNA decay during apoptosis is initiated by the mitochondrial exoribonuclease PNPT1.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.017
       
  • Intermittent Pili-Mediated Forces Fluidize Neisseria meningitidis
           Aggregates Promoting Vascular Colonization
    • Authors: Daria Bonazzi; Valentina Lo Schiavo, Silke Machata, Ilyas Djafer-Cherif, Pierre Nivoit, Valeria Manriquez, Hirokazu Tanimoto, Julien Husson, Nelly Henry, Hugues Chaté, Raphael Voituriez, Guillaume Duménil
      Abstract: Meningitis-causing bacteria form viscous fluid aggregates in blood vessels with high bacterial diffusion that enhance infection.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.010
       
  • Next-Generation Machine Learning for Biological Networks
    • Authors: Diogo M. Camacho; Katherine M. Collins, Rani K. Powers, James C. Costello, James J. Collins
      First page: 1581
      Abstract: Machine-learning approaches are essential for pulling information out of the vast datasets that are being collected across biology and biomedicine. This Review considers the opportunities and challenges at the intersection of network biology and data science.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.015
       
  • A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate
           Stabilization
    • Authors: Maike M.K. Hansen; Winnie Y. Wen, Elena Ingerman, Brandon S. Razooky, Cassandra E. Thompson, Roy D. Dar, Charles W. Chin, Michael L. Simpson, Leor S. Weinberger
      First page: 1609
      Abstract: Noise helps drive fate decisions, and a mechanism rooted in alternative splicing allows cells to stop dithering and commit.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.04.005
       
  • The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting
           C-Terminal Degrons
    • Authors: Itay Koren; Richard T. Timms, Tomasz Kula, Qikai Xu, Mamie Z. Li, Stephen J. Elledge
      First page: 1622
      Abstract: C-terminal degron motifs regulate mammalian protein stability via interactions with Cullin-RING E3 ubiquitin ligase complexes.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.028
       
  • Structure of an Ancient Respiratory System
    • Authors: Hongjun Yu; Chang-Hao Wu, Gerrit J. Schut, Dominik K. Haja, Gongpu Zhao, John W. Peters, Michael W.W. Adams, Huilin Li
      First page: 1636
      Abstract: The structure of a respiratory complex from a hyperthermophilic archaeon offers insights into the evolution of mitochondrial complex I
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.071
       
  • Structural Basis for Transcript Elongation Control by NusG Family
           Universal Regulators
    • Authors: Jin Young Kang; Rachel Anne Mooney, Yuri Nedialkov, Jason Saba, Tatiana V. Mishanina, Irina Artsimovitch, Robert Landick, Seth A. Darst
      First page: 1650
      Abstract: NusG/Spt5 transcription elongation factors are the only transcription regulators conserved across all domains of life, assisting RNA polymerase elongation and linking the transcription complex to additional accessory factors genome wide. Cryo-electron microscopy structures of bacterial transcription complexes with NusG or its operon-specific paralog RfaH suggest NusG/RfaH inhibit backtrack pausing by stabilizing the upstream duplex DNA following the transcription bubble. RfaH further supresses pausing and termination by preventing RNA-hairpin induced swiveling, an RNA polymerase conformational change associated with pausing.
      Citation: Cell (2018)
      PubDate: 2018-06-07
      DOI: 10.1016/j.cell.2018.05.017
       
  • Dynamic Architecture of DNA Repair Complexes and the Synaptonemal Complex
           at Sites of Meiotic Recombination
    • Authors: Alexander Woglar; Anne M. Villeneuve
      First page: 1678
      Abstract: Structured-illumination microscopy of meiotic chromosomes reveals that distinct architecture and spatial compartmentalization are associated with differential timing and outcome of repair at crossover and non-crossover sites.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.066
       
  • Disease Heritability Inferred from Familial Relationships Reported in
           Medical Records
    • Authors: Fernanda C.G. Polubriaginof; Rami Vanguri, Kayla Quinnies, Gillian M. Belbin, Alexandre Yahi, Hojjat Salmasian, Tal Lorberbaum, Victor Nwankwo, Li Li, Mark M. Shervey, Patricia Glowe, Iuliana Ionita-Laza, Mary Simmerling, George Hripcsak, Suzanne Bakken, David Goldstein, Krzysztof Kiryluk, Eimear E. Kenny, Joel Dudley, David K. Vawdrey, Nicholas P. Tatonetti
      First page: 1692
      Abstract: Electronic health records can be mined for familial relationships that provide distinct insights into heritability of human disease.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.032
       
  • Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel
           Glutamate Biosynthetic Pathway in the Brain
    • Authors: Hongying Zhu; Ning Wang, Lei Yao, Qi Chen, Ran Zhang, Junchao Qian, Yiwen Hou, Weiwei Guo, Sijia Fan, Siling Liu, Qiaoyun Zhao, Feng Du, Xin Zuo, Yujun Guo, Yan Xu, Jiali Li, Tian Xue, Kai Zhong, Xiaoyuan Song, Guangming Huang, Wei Xiong
      First page: 1716
      Abstract: UV-induced upregulation of a small molecule feeds into an intraneuronal metabolic pathway for glutamate biosynthesis that can enhance learning and memory.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.014
       
  • The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet
    • Authors: Christine A. Olson; Helen E. Vuong, Jessica M. Yano, Qingxing Y. Liang, David J. Nusbaum, Elaine Y. Hsiao
      First page: 1728
      Abstract: The beneficial effects of a ketogenic diet on epileptic seizures are mediated by the gut microbiome through their modulation of hippocampal GABA/glutamate ratios.
      Citation: Cell (2018)
      PubDate: 2018-05-24
      DOI: 10.1016/j.cell.2018.04.027
       
  • Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer
    • Authors: Allen W. Zhang; Andrew McPherson, Katy Milne, David R. Kroeger, Phineas T. Hamilton, Alex Miranda, Tyler Funnell, Nicole Little, Camila P.E. de Souza, Sonya Laan, Stacey LeDoux, Dawn R. Cochrane, Jamie L.P. Lim, Winnie Yang, Andrew Roth, Maia A. Smith, Julie Ho, Kane Tse, Thomas Zeng, Inna Shlafman, Michael R. Mayo, Richard Moore, Henrik Failmezger, Andreas Heindl, Yi Kan Wang, Ali Bashashati, Diljot S. Grewal, Scott D. Brown, Daniel Lai, Adrian N.C. Wan, Cydney B. Nielsen, Curtis Huebner, Basile Tessier-Cloutier, Michael S. Anglesio, Alexandre Bouchard-Côté, Yinyin Yuan, Wyeth W. Wasserman, C. Blake Gilks, Anthony N. Karnezis, Samuel Aparicio, Jessica N. McAlpine, David G. Huntsman, Robert A. Holt, Brad H. Nelson, Sohrab P. Shah
      First page: 1755
      Abstract: Integrated multi-region analysis of metastatic sites in patients with high-grade ovarian cancer highlights the connection between immune microenvironment variation and malignant spread, as well as the combinatorial prognostic value of immune and mutational features.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.073
       
  • Identification of Near-Pan-neutralizing Antibodies against HIV-1 by
           Deconvolution of Plasma Humoral Responses
    • Authors: Mohammad Mohseni Sajadi; Amir Dashti, Zahra Rikhtegaran Tehrani, William D. Tolbert, Michael S. Seaman, Xin Ouyang, Neelakshi Gohain, Marzena Pazgier, Dongkyoon Kim, Guy Cavet, Jean Yared, Robert R. Redfield, George K. Lewis, Anthony L. DeVico
      First page: 1783
      Abstract: An HIV-neutralizing antibody achieves near-pan-neutralizing activity through recognition of a highly conserved, difficult-to-access region of the viral gp120 glycoprotein.
      Citation: Cell (2018)
      PubDate: 2018-05-03
      DOI: 10.1016/j.cell.2018.03.061
       
  • Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide
           Mechanisms that Control Transcription Factor Binding and Function
    • Authors: Verena M. Link; Sascha H. Duttke, Hyun B. Chun, Inge R. Holtman, Emma Westin, Marten A. Hoeksema, Yohei Abe, Dylan Skola, Casey E. Romanoski, Jenhan Tao, Gregory J. Fonseca, Ty D. Troutman, Nathanael J. Spann, Tobias Strid, Mashito Sakai, Miao Yu, Rong Hu, Rongxin Fang, Dirk Metzler, Bing Ren, Christopher K. Glass
      First page: 1796
      Abstract: Analyses of genetic variation in macrophages from inbred mouse strains reveal how a complex network of transcription factors influence cis-regulatory elements to impact differentiation and responses to environmental change.
      Citation: Cell (2018)
      PubDate: 2018-05-17
      DOI: 10.1016/j.cell.2018.04.018
       
  • LlamaTags: A Versatile Tool to Image Transcription Factor Dynamics in Live
           Embryos
    • Authors: Jacques P. Bothma; Matthew R. Norstad, Simon Alamos, Hernan G. Garcia
      First page: 1810
      Abstract: A fluorescent protein tagging strategy reveals a role for inter-nuclear signaling and coordination of protein levels between neighboring nuclei in Drosophila embryogenesis.
      Citation: Cell (2018)
      PubDate: 2018-05-10
      DOI: 10.1016/j.cell.2018.03.069
       
 
 
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