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Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3183 journals]
  • The Texture of Chromatin
    • Authors: Fedor Kouzine; David Levens
      Pages: 579 - 581
      Abstract: DNA-replication machinery introduces intertwining and supercoiling of DNA strands as it traverses the double helix, which could impede replication and compromise genome stability. A new study in Cell shows that the intrinsic physical properties of chromatin fibers dictate how torsional stress is partitioned to minimize these risks and facilitate DNA replication.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.026
      Issue No: Vol. 179, No. 3 (2019)
  • PiRNAs Rise to Rescue Koalas
    • Authors: Astrid D. Haase; Todd S. Macfarlan
      Pages: 582 - 583
      Abstract: PIWI-interacting small RNAs (piRNAs) establish sequence-specific adaptive restriction of resident genomic parasites to guard genome integrity. In this issue of Cell, Yu, Koppetsch, et al. describe an innate piRNA-response that specifically fragments the viral RNA genome in the germline of recently invaded koalas. This first line of defense might ensure survival until adaptive immunity develops.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.025
      Issue No: Vol. 179, No. 3 (2019)
  • An Affair to Remember: How an Endosymbiont Partners with Its Host to Build
           a Cell Envelope
    • Authors: Atanas D. Radkov; Seemay Chou
      Pages: 584 - 586
      Abstract: Studying endosymbionts gives us insight into early cellular mechanisms that lead to the emergence of eukaryotic organelles. In this issue of Cell, Bublitz et al. (2019) report on how a nested bacterial endosymbiont of mealybugs builds its cell wall peptidoglycan through a biosynthetic pathway that is dependent on transported host enzymes.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.024
      Issue No: Vol. 179, No. 3 (2019)
  • An Ancient Genome from the Indus Valley Civilization
    • Authors: Maanasa Raghavan; Hannes Schroeder, Anna-Sapfo Malaspinas
      Pages: 586 - 588
      Abstract: Shinde et al. report the first genome-wide data from an ancient individual from the Indus Valley Civilization in South Asia. Their findings have implications for the origins and spread of farming and Indo-European languages in the region and the makings of the South Asian gene pool.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.027
      Issue No: Vol. 179, No. 3 (2019)
  • Genome-wide Association Studies in Ancestrally Diverse Populations:
           Opportunities, Methods, Pitfalls, and Recommendations
    • Authors: Roseann E. Peterson; Karoline Kuchenbaecker, Raymond K. Walters, Chia-Yen Chen, Alice B. Popejoy, Sathish Periyasamy, Max Lam, Conrad Iyegbe, Rona J. Strawbridge, Leslie Brick, Caitlin E. Carey, Alicia R. Martin, Jacquelyn L. Meyers, Jinni Su, Junfang Chen, Alexis C. Edwards, Allan Kalungi, Nastassja Koen, Lerato Majara, Emanuel Schwarz, Jordan W. Smoller, Eli A. Stahl, Patrick F. Sullivan, Evangelos Vassos, Bryan Mowry, Miguel L. Prieto, Alfredo Cuellar-Barboza, Tim B. Bigdeli, Howard J. Edenberg, Hailiang Huang, Laramie E. Duncan
      Pages: 589 - 603
      Abstract: With increasing representation of global populations in genetic studies, there is an opportunity for advanced methods development and a need for consensus “best practices” for analyzing datasets. We provide background on the scientific and ethical importance of including underrepresented groups in genetics research and offer guidance for genome-wide analysis of ancestrally diverse study cohorts.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.cell.2019.08.051
      Issue No: Vol. 179, No. 3 (2019)
  • R Loops: From Physiological to Pathological Roles
    • Authors: Tatiana García-Muse; Andrés Aguilera
      Pages: 604 - 618
      Abstract: DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional structures with a negative impact on transcription, replication and DNA repair. Accumulating evidence suggests that they constitute a source of replication stress, DNA breaks and genome instability. Reciprocally, DNA breaks facilitate DNA-RNA hybrid formation by releasing the double helix torsional conformation. Cells avoid DNA-RNA accumulation by either preventing or removing hybrids directly or by DNA repair-coupled mechanisms. Given the R-loop impact on chromatin and genome organization and its potential relation with genetic diseases, we review R-loop homeostasis as well as their physiological and pathological roles.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.cell.2019.08.055
      Issue No: Vol. 179, No. 3 (2019)
  • Synergistic Coordination of Chromatin Torsional Mechanics and
           Topoisomerase Activity
    • Authors: Tung T. Le; Xiang Gao, Seong ha Park, Jaeyoon Lee, James T. Inman, Joyce H. Lee, Jessica L. Killian, Ryan P. Badman, James M. Berger, Michelle D. Wang
      Pages: 619 - 631.e15
      Abstract: The material properties of eukaryotic chromatin fibers partition supercoiling ahead of progressing replication forks, illustrating that chromatin provides a buffer against torsional stress and that its unique mechanical properties help to facilitate replication and minimize genome instability.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.034
      Issue No: Vol. 179, No. 3 (2019)
  • The piRNA Response to Retroviral Invasion of the Koala Genome
    • Authors: Tianxiong Yu; Birgit S. Koppetsch, Sara Pagliarani, Stephen Johnston, Noah J. Silverstein, Jeremy Luban, Keith Chappell, Zhiping Weng, William E. Theurkauf
      Pages: 632 - 643.e12
      Abstract: KoRV-A retroviral invasion of the koala germline provides insights into an “innate” genome immune response.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.cell.2019.09.002
      Issue No: Vol. 179, No. 3 (2019)
  • Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection
    • Authors: Zhenda Shi; Jun Zou, Zhan Zhang, Xu Zhao, Juan Noriega, Benyue Zhang, Chunyu Zhao, Harshad Ingle, Kyle Bittinger, Lisa M. Mattei, Andrea J. Pruijssers, Richard K. Plemper, Timothy J. Nice, Megan T. Baldridge, Terence S. Dermody, Benoit Chassaing, Andrew T. Gewirtz
      Pages: 644 - 658.e13
      Abstract: A bacterium can protect against rotavirus infection in mice independent of the immune system.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-10
      DOI: 10.1016/j.cell.2019.09.028
      Issue No: Vol. 179, No. 3 (2019)
  • Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel
    • Authors: Alanna E. McCarthy; Craig Yoshioka, Steven E. Mansoor
      Pages: 659 - 670.e13
      Abstract: Structures of the full-length P2X7 receptor provide the first insights into the architecture and function of a P2X receptor cytoplasmic domain, which includes a unique cytoplasmic ballast fold containing a zinc ion complex and a guanosine nucleotide binding site as well as an understanding of how palmitoylation of the C-cys anchor prevents receptor desensitization.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-03
      DOI: 10.1016/j.cell.2019.09.017
      Issue No: Vol. 179, No. 3 (2019)
  • Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis
    • Authors: Bernhard Hampoelz; Andre Schwarz, Paolo Ronchi, Helena Bragulat-Teixidor, Christian Tischer, Imre Gaspar, Anne Ephrussi, Yannick Schwab, Martin Beck
      Pages: 671 - 686.e17
      Abstract: Nuclear pores form through progressive condensation events during oogenesis
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.022
      Issue No: Vol. 179, No. 3 (2019)
  • Generation of Blastocyst-like Structures from Mouse Embryonic and Adult
           Cell Cultures
    • Authors: Ronghui Li; Cuiqing Zhong, Yang Yu, Haisong Liu, Masahiro Sakurai, Leqian Yu, Zheying Min, Lei Shi, Yulei Wei, Yuta Takahashi, Hsin-Kai Liao, Jie Qiao, Hongkui Deng, Estrella Nuñez-Delicado, Concepcion Rodriguez Esteban, Jun Wu, Juan Carlos Izpisua Belmonte
      Pages: 687 - 702.e18
      Abstract: A blastocyst-like structure is generated from a single stem-cell type as well as from somatic reprogrammed cells, and these artificial embryo-like structures can implant, induce decidualization, and give rise to cells of the three embryonic founding tissues: epiblast, trophectoderm, and primitive endoderm.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.029
      Issue No: Vol. 179, No. 3 (2019)
  • Peptidoglycan Production by an Insect-Bacterial Mosaic
    • Authors: DeAnna C. Bublitz; Grayson L. Chadwick, John S. Magyar, Kelsi M. Sandoz, Diane M. Brooks, Stéphane Mesnage, Mark S. Ladinsky, Arkadiy I. Garber, Pamela J. Bjorkman, Victoria J. Orphan, John P. McCutcheon
      Pages: 703 - 712.e7
      Abstract: A functional biosynthetic pathway formed from a combination of genes encoded by a bacterial endosymbiont and its insect host exhibits strong parallels to organelle evolution.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-03
      DOI: 10.1016/j.cell.2019.08.054
      Issue No: Vol. 179, No. 3 (2019)
  • Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling
           Social Behavior
    • Authors: Dong-Wook Kim; Zizhen Yao, Lucas T. Graybuck, Tae Kyung Kim, Thuc Nghi Nguyen, Kimberly A. Smith, Olivia Fong, Lynn Yi, Noushin Koulena, Nico Pierson, Sheel Shah, Liching Lo, Allan-Hermann Pool, Yuki Oka, Lior Pachter, Long Cai, Bosiljka Tasic, Hongkui Zeng, David J. Anderson
      Pages: 713 - 728.e17
      Abstract: Single-cell RNA sequencing of the mouse ventrolateral subdivision of the ventromedial hypothalamus, a brain region that contains ∼4,000 neurons and controls innate social behaviors including aggression and mounting, reveals several transcriptomic cell types that differ between males and females.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.020
      Issue No: Vol. 179, No. 3 (2019)
  • An Ancient Harappan Genome Lacks Ancestry from Steppe Pastoralists or
           Iranian Farmers
    • Authors: Vasant Shinde; Vagheesh M. Narasimhan, Nadin Rohland, Swapan Mallick, Matthew Mah, Mark Lipson, Nathan Nakatsuka, Nicole Adamski, Nasreen Broomandkhoshbacht, Matthew Ferry, Ann Marie Lawson, Megan Michel, Jonas Oppenheimer, Kristin Stewardson, Nilesh Jadhav, Yong Jun Kim, Malavika Chatterjee, Avradeep Munshi, Amrithavalli Panyam, Pranjali Waghmare, Yogesh Yadav, Himani Patel, Amit Kaushik, Kumarasamy Thangaraj, Matthias Meyer, Nick Patterson, Niraj Rai, David Reich
      Pages: 729 - 735.e10
      Abstract: A genome from the Indus Valley Civilization is from a population that is the largest source for South Asians. The population has no detectable ancestry from Steppe pastoralists or from Anatolian and Iranian farmers, suggesting farming in South Asia arose from local foragers rather than from large-scale migration from the West.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-09-05
      DOI: 10.1016/j.cell.2019.08.048
      Issue No: Vol. 179, No. 3 (2019)
  • Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in
    • Authors: Degang Wu; Jinzhuang Dou, Xiaoran Chai, Claire Bellis, Andreas Wilm, Chih Chuan Shih, Wendy Wei Jia Soon, Nicolas Bertin, Clarabelle Bitong Lin, Chiea Chuen Khor, Michael DeGiorgio, Shanshan Cheng, Li Bao, Neerja Karnani, William Ying Khee Hwang, Sonia Davila, Patrick Tan, Asim Shabbir, Angela Moh, Eng-King Tan, Jia Nee Foo, Liuh Ling Goh, Khai Pang Leong, Roger S.Y. Foo, Carolyn Su Ping Lam, Arthur Mark Richards, Ching-Yu Cheng, Tin Aung, Tien Yin Wong, Huck Hui Ng, SG10K Consortium, Jianjun Liu, Chaolong Wang
      Pages: 736 - 749.e15
      Abstract: Because of Singapore’s unique history of immigration, whole-genome sequence analysis of 4,810 Singaporeans provides a snapshot of the genetic diversity across East, Southeast, and South Asia.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.019
      Issue No: Vol. 179, No. 3 (2019)
  • Genetic Control of Expression and Splicing in Developing Human Brain
           Informs Disease Mechanisms
    • Authors: Rebecca L. Walker; Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind
      Pages: 750 - 771.e22
      Abstract: An atlas of expression and splice quantitative trait loci from mid-gestational human brain is integrated with genetic risk for schizophrenia, suggesting additional causal genes and highlighting the importance of QTL datasets derived from developmental stages most relevant to disease initiation.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.021
      Issue No: Vol. 179, No. 3 (2019)
  • High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ
    • Authors: Xiaoyin Chen; Yu-Chi Sun, Huiqing Zhan, Justus M. Kebschull, Stephan Fischer, Katherine Matho, Z. Josh Huang, Jesse Gillis, Anthony M. Zador
      Pages: 772 - 786.e19
      Abstract: BARseq is a high-throughput, multiplexed method based on RNA barcoding that helps bridge anatomical and transcriptomic approaches at cellular resolution with the potential to discover organizing principles of neural circuits as exemplified by the uncovering of distinct, transcriptionally defined subtype projections in the mouse auditory cortex.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.023
      Issue No: Vol. 179, No. 3 (2019)
  • Optical Pooled Screens in Human Cells
    • Authors: David Feldman; Avtar Singh, Jonathan L. Schmid-Burgk, Rebecca J. Carlson, Anja Mezger, Anthony J. Garrity, Feng Zhang, Paul C. Blainey
      Pages: 787 - 799.e17
      Abstract: A screening approach that combines high-content imaging with in situ sequencing can identify genes that affect spatially and temporally defined phenotypes like morphology and subcellular localization, expanding the list of scientific questions that can be asked with genetic tools.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.016
      Issue No: Vol. 179, No. 3 (2019)
  • BACH1 Orchestrates Lung Cancer Metastasis
    • Authors: Nicole M. Anderson; M. Celeste Simon
      First page: 800
      Abstract: (Cell 178, 265–267; July 11, 2019)
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.032
      Issue No: Vol. 179, No. 3 (2019)
  • Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila
    • Authors: Zelha Nil; Rubén Hervás, Therese Gerbich, Paulo Leal, Zulin Yu, Anita Saraf, Mihaela Sardiu, Jeffrey J. Lange, Kexi Yi, Jay Unruh, Brian Slaughter, Kausik Si
      First page: 801
      Abstract: (Cell 178, 1403–1420.e1–e11; September 5, 2019)
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.033
      Issue No: Vol. 179, No. 3 (2019)
  • SnapShot: S-Phase Entry and Exit
    • Authors: Andrew Burgess; Jenny Vuong, Kamila A. Marzec, Ulrik Nicolai de Lichtenberg, Seán I. O’Donoghue, Lars Juhl Jensen
      Pages: 802 - 802.e1
      Abstract: S-phase entry and exit are regulated by hundreds of protein complexes that assemble “just in time,” orchestrated by a multitude of distinct events. To help understand their interplay, we have created a tailored visualization based on the Minardo layout, highlighting over 80 essential events. This complements our earlier visualization of M-phase, and both can be displayed together, giving a comprehensive overview of the events regulating the cell division cycle. To view this SnapShot, open or download the PDF.
      Citation: Cell 179, 3 (2019)
      PubDate: 2019-10-17
      DOI: 10.1016/j.cell.2019.09.031
      Issue No: Vol. 179, No. 3 (2019)
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