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ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3162 journals]
  • Interred with Their DNA
    • Authors: Stacie Dodgson
      First page: 299
      Abstract: We, as humans, have long been fascinated by our history both as individuals and as a species, and questions of personal ancestry are increasingly becoming answerable by the popularization of genetic testing services such as those offered by and 23andMe. Beyond our individual provenance, however, is the question of the history of humankind, and the relatively recent explosion in the field of ancient DNA research is rising to this challenge. The insights into early human history that can be gleaned from sequencing and careful analysis of ancient genomes are myriad, and 2018 has been rife with exciting discoveries that are illuminating our origin story.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.023
      Issue No: Vol. 175, No. 2 (2018)
  • Addressing Diversity and Inclusion in Human Genetics Research
    • Pages: 303 - 305
      Abstract: Diversity is literally built into our DNA. Mutation, recombination, and non-assortative mating have all contributed to the wonderful explosion in human variation we witness today. Though humans largely share a common genetic blueprint, they also exhibit marvelous diversity in phenotype, including susceptibility to disease. It is foolish to ignore the full catalog of human genetic variation. The larger the lens, the wider the swath of biology we can capture; the longer the generation tree, the more time for mutations to occur; the broader the geography, the greater the opportunity for genetic drift and natural selection.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.034
      Issue No: Vol. 175, No. 2 (2018)
  • Simultaneous Viral Exposure and Protection from Neanderthal Introgression
    • Authors: Emilia Huerta-Sánchez; Fergal P. Casey
      Pages: 306 - 307
      Abstract: In this issue, Enard and Petrov present intriguing results on the possibility of genetic traces left behind in our genomes from adaptation to past viral epidemics that may have been initiated by interaction with Neanderthal archaic hominins. The work highlights how powerful infectious agents can act as a selective force to shape our genetic makeup.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.019
      Issue No: Vol. 175, No. 2 (2018)
  • Aster: A New Star in Cholesterol Trafficking
    • Authors: Vassily I. Kutyavin; Ajay Chawla
      Pages: 307 - 309
      Abstract: Life evolved in an aqueous environment, necessitating the evolution of carrier proteins to shuttle lipophilic molecules within and between cells. Sandhu et. al. (2018) report the discovery of a long-sought-after cholesterol carrier protein, named Aster, which transports cholesterol from the plasma membrane to the endoplasmic reticulum.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.025
      Issue No: Vol. 175, No. 2 (2018)
  • Exposing a Virus Hiding in the Animal Facility
    • Authors: Colin R. Parrish
      Pages: 310 - 311
      Abstract: Roediger et al. (2018) demonstrate that a kidney disease characterized by apparently spontaneous nephropathy that had been recognized in laboratory mice for many years is caused by a newly recognized virus named the mouse kidney parvovirus (MKPV). That virus appears to be widespread in mouse colonies as it is not detected by current diagnostic tools, and its recognition presents new opportunities for understanding the pathology of tubulointerstitial fibrosis.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.033
      Issue No: Vol. 175, No. 2 (2018)
  • Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth
    • Authors: Dennis H. Kim
      Pages: 311 - 312
      Abstract: Siderophores are small molecules produced by bacteria that bind ferric iron in the surrounding environment with extraordinary affinity. A new study provides evidence that a simple animal host, Caenorhabditis elegans, co-opts siderophores to promote its own iron acquisition and growth.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.020
      Issue No: Vol. 175, No. 2 (2018)
  • A Paradigm Shift in Cancer Immunotherapy: From Enhancement to
    • Authors: Miguel F. Sanmamed; Lieping Chen
      Pages: 313 - 326
      Abstract: This Perspective discusses the concept of immune normalization and how its underlying principles may help to augment, as well as design, cancer immunotherapies.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.035
      Issue No: Vol. 175, No. 2 (2018)
  • The Cellular and Molecular Basis for Planarian Regeneration
    • Authors: Peter W. Reddien
      Pages: 327 - 345
      Abstract: The regenerative capacity of flatworms has inspired centuries of inquiry in hopes of understanding and manipulating cellular regeneration in other systems. This Review proposes a unified model for the cellular and molecular basis of regeneration based on stem cells and the positional information that guides them.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.021
      Issue No: Vol. 175, No. 2 (2018)
  • Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic
           Associations, Patterns of Viral Infections, and Chinese Population History
    • Authors: Siyang Liu; Shujia Huang, Fang Chen, Lijian Zhao, Yuying Yuan, Stephen Starko Francis, Lin Fang, Zilong Li, Long Lin, Rong Liu, Yong Zhang, Huixin Xu, Shengkang Li, Yuwen Zhou, Robert W. Davies, Qiang Liu, Robin G. Walters, Kuang Lin, Jia Ju, Thorfinn Korneliussen, Melinda A. Yang, Qiaomei Fu, Jun Wang, Lijun Zhou, Anders Krogh, Hongyun Zhang, Wei Wang, Zhengming Chen, Zhiming Cai, Ye Yin, Huanming Yang, Mao Mao, Jay Shendure, Jian Wang, Anders Albrechtsen, Xin Jin, Rasmus Nielsen, Xun Xu
      Pages: 347 - 359.e14
      Abstract: Large-scale analysis of genome sequences from non-invasive prenatal testing in Chinese women yields insights into phenotypic trait associations, viral infection patterns, and population history.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.08.016
      Issue No: Vol. 175, No. 2 (2018)
  • Evidence that RNA Viruses Drove Adaptive Introgression between
           Neanderthals and Modern Humans
    • Authors: David Enard; Dmitri A. Petrov
      Pages: 360 - 371.e13
      Abstract: Human genome evolution after Neanderthal interbreeding was shaped by viral infections and the resulting selection for ancient alleles of viral-interacting protein genes.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.08.034
      Issue No: Vol. 175, No. 2 (2018)
  • Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by
    • Authors: Shicheng Su; Jinghua Zhao, Yue Xing, Xiaoqian Zhang, Jiang Liu, Qian Ouyang, Jianing Chen, Fengxi Su, Qiang Liu, Erwei Song
      Pages: 442 - 457.e23
      Abstract: Therapeutic antibody-based cancer treatment leads to ADCP-induced, AIM2-mediated immunosuppression by macrophages that can be overcome with concomitant immune checkpoint blockade.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.007
      Issue No: Vol. 175, No. 2 (2018)
  • The Human Transcription Factors
    • Authors: Samuel A. Lambert; Arttu Jolma, Laura F. Campitelli, Pratyush K. Das, Yimeng Yin, Mihai Albu, Xiaoting Chen, Jussi Taipale, Timothy R. Hughes, Matthew T. Weirauch
      Pages: 598 - 599
      Abstract: (Cell 172, 650–665; February 8, 2018)
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.045
      Issue No: Vol. 175, No. 2 (2018)
  • SnapShot: RNA Structure Probing Technologies
    • Authors: Paul D. Carlson; Molly E. Evans, Angela M Yu, Eric J. Strobel, Julius B. Lucks
      Pages: 600 - 600.e1
      Abstract: Chemical probing coupled to high-throughput sequencing offers a flexible approach to uncover many aspects of RNA structure relevant to its cellular function. With a wide variety of chemical probes available that each report on different features of RNA molecules, a broad toolkit exists for investigating in vivo and in vitro RNA structure and interactions with other molecules.
      Citation: Cell 175, 2 (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.024
      Issue No: Vol. 175, No. 2 (2018)
  • In Toto Imaging and Reconstruction of Post-Implantation Mouse Development
           at the Single-Cell Level
    • Authors: Katie McDole; Léo Guignard, Fernando Amat, Andrew Berger, Grégoire Malandain, Loïc A. Royer, Srinivas C. Turaga, Kristin Branson, Philipp J. Keller
      Abstract: Adaptive light-sheet microscopy is used to establish a dynamic atlas of post-implantation mouse development at the single-cell level.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.031
  • Evolution of Metastases in Space and Time under Immune Selection
    • Authors: Mihaela Angelova; Bernhard Mlecnik, Angela Vasaturo, Gabriela Bindea, Tessa Fredriksen, Lucie Lafontaine, Bénédicte Buttard, Erwan Morgand, Daniela Bruni, Anne Jouret-Mourin, Catherine Hubert, Alex Kartheuser, Yves Humblet, Michele Ceccarelli, Najeeb Syed, Francesco M. Marincola, Davide Bedognetti, Marc Van den Eynde, Jérôme Galon
      Abstract: A longitudinal analysis of clonal evolution of tumors across multiple tissues identifies a parallel selection model that explains the role of immune editing in controlling metastatic growth.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.018
  • Nonoscillatory Phase Coding and Synchronization in the Bat Hippocampal
    • Authors: Tamir Eliav; Maya Geva-Sagiv, Michael M. Yartsev, Arseny Finkelstein, Alon Rubin, Liora Las, Nachum Ulanovsky
      Abstract: Measurements in freely moving bats reveal that hippocampal neurons encode the animal’s position through temporal coding but in the absence of the oscillations observed in rodents.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.017
  • Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control
    • Authors: Masashi Tabuchi; Joseph D. Monaco, Grace Duan, Benjamin Bell, Sha Liu, Qili Liu, Kechen Zhang, Mark N. Wu
      Abstract: Temporal patterns of Drosophila clock neuron firing are sufficient to drive synaptic plasticity, impacting neuronal function and behavior.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.016
  • Structural Insights into Mdn1, an Essential AAA Protein Required for
           Ribosome Biogenesis
    • Authors: Zhen Chen; Hiroshi Suzuki, Yuki Kobayashi, Ashley C. Wang, Frank DiMaio, Shigehiro A. Kawashima, Thomas Walz, Tarun M. Kapoor
      Abstract: Structural insights into Mdn1 reveal how conformational changes in this ∼540 kDa AAA protein contribute to ribosome assembly.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.015
  • The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links
           Mitochondria to Brain Development
    • Authors: Andrew T.N. Tebbenkamp; Luis Varela, Jinmyung Choi, Miguel I. Paredes, Alice M. Giani, Jae Eun Song, Matija Sestan-Pesa, Daniel Franjic, André M.M. Sousa, Zhong-Wu Liu, Mingfeng Li, Candace Bichsel, Marco Koch, Klara Szigeti-Buck, Fuchen Liu, Zhuo Li, Yuka I. Kawasawa, Constantinos D. Paspalas, Yann S. Mineur, Paolo Prontera, Giuseppe Merla, Marina R. Picciotto, Amy F.T. Arnsten, Tamas L. Horvath, Nenad Sestan
      Abstract: Reduced copy number of DNAJC30, now shown to interact with the mitochondrial ATP synthase, leads to mitochondrial dysfunction underlying neuronal defects in Williams syndrome.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.014
  • CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear
    • Authors: Haifeng Wang; Xiaoshu Xu, Cindy M. Nguyen, Yanxia Liu, Yuchen Gao, Xueqiu Lin, Timothy Daley, Nathan H. Kipniss, Marie La Russa, Lei S. Qi
      Abstract: An engineered CRISPR-based platform for inducible recruitment of specific genomic loci to distinct nuclear compartments reveals positional effects on gene expression and cellular function.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.013
  • Centromeres License the Mitotic Condensation of Yeast Chromosome Arms
    • Authors: Tom Kruitwagen; Pierre Chymkowitch, Annina Denoth-Lippuner, Jorrit Enserink, Yves Barral
      Abstract: Yeast centromeres propagate a cis-acting chromosome condensation signal.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.012
  • Phosphorylation-Mediated IFN-γR2 Membrane Translocation Is Required to
           Activate Macrophage Innate Response
    • Authors: Xiaoqing Xu; Jia Xu, Jiacheng Wu, Ye Hu, Yanmei Han, Yan Gu, Kai Zhao, Qian Zhang, Xingguang Liu, Juan Liu, Bing Liu, Xuetao Cao
      Abstract: Membrane translocation of cytoplasmic IFN-γR2 is a critical step for the activation of macrophage innate response against intracellular bacterial infection.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.011
  • Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in
           Macrophage Imprinting
    • Authors: Merav Cohen; Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido Amit
      Abstract: A population of resident basophils regulates the development and function of alveolar macrophages to control lung homeostasis.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.009
  • Statistical Detection of Relatives Typed with Disjoint Forensic and
           Biomedical Loci
    • Authors: Jaehee Kim; Michael D. Edge, Bridget F.B. Algee-Hewitt, Jun Z. Li, Noah A. Rosenberg
      Abstract: Genetic data from databases that use nonoverlapping marker sets, such as forensic genetic databases and biomedical and genealogical databases, can be used to connect close relatives, with implications for forensic genetics and genomic privacy.
      Citation: Cell (2018)
      PubDate: 2018-10-11
      DOI: 10.1016/j.cell.2018.09.008
  • An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by
           Metabolic State
    • Authors: Clair Crewe; Nolwenn Joffin, Joseph M. Rutkowski, Min Kim, Fang Zhang, Dwight A. Towler, Ruth Gordillo, Philipp E. Scherer
      Abstract: Extracellular vesicles exchange protein and lipid signals between endothelial cells and adipocytes conveying information about nutrient state changes from the blood in adipose tissues.
      Citation: Cell (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.09.005
  • Intestinal Dysmotility Syndromes following Systemic Infection by
    • Authors: James P. White; Shanshan Xiong, Nicole P. Malvin, William Khoury-Hanold, Robert O. Heuckeroth, Thaddeus S. Stappenbeck, Michael S. Diamond
      Abstract: Damage caused to enteric neurons during acute flavivirus infections manifests in the form of gastrointestinal motility abnormalities that are exacerbated in later life upon challenge with either unrelated infectious or non-infectious inflammatory stimuli.
      Citation: Cell (2018)
      PubDate: 2018-10-04
      DOI: 10.1016/j.cell.2018.08.069
  • The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant
    • Authors: Yun Xia; Yonghua Xie, Zhengsen Yu, Hongying Xiao, Guimei Jiang, Xiaoying Zhou, Yunyun Yang, Xin Li, Meng Zhao, Liping Li, Mingke Zheng, Shuai Han, Zhaoyun Zong, Xianbin Meng, Haiteng Deng, Huahu Ye, Yunzhi Fa, Haitao Wu, Eric Oldfield, Xiaoyu Hu, Wanli Liu, Yan Shi, Yonghui Zhang
      Abstract: Lipophilic statins and bisphosphonates that target three enzymes in the mevalonate pathway have vaccine adjuvant activities in mice and monkeys and can synergize with anti-PD1 therapy.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.070
  • A Map-like Micro-Organization of Grid Cells in the Medial Entorhinal
    • Authors: Yi Gu; Sam Lewallen, Amina A. Kinkhabwala, Cristina Domnisoru, Kijung Yoon, Jeffrey L. Gauthier, Ila R. Fiete, David W. Tank
      Abstract: Grid cells, which represent a cognitive code for location during navigation, are arranged so that their anatomical organization largely matches their spatial tuning phases.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.066
  • Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along
           the Intestinal Villus Axis
    • Authors: Andreas E. Moor; Yotam Harnik, Shani Ben-Moshe, Efi E. Massasa, Milena Rozenberg, Raya Eilam, Keren Bahar Halpern, Shalev Itzkovitz
      Abstract: A broadly applicable single-cell spatial transcriptomics approach reveals broad regional and functional heterogeneity of small intestinal enterocytes.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.063
  • Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in
           Intrinsically Photosensitive Retinal Ganglion Cells
    • Authors: Zheng Jiang; Wendy W.S. Yue, Lujing Chen, Yanghui Sheng, King-Wai Yau
      Abstract: Discovery in retinal ganglion cells of a ciliary phototransduction pathway that uses cyclic nucleotide as the second messenger and HCN as the effector ion channel has evolutionary implications.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.055
  • Protein AMPylation by an Evolutionarily Conserved Pseudokinase
    • Authors: Anju Sreelatha; Samantha S. Yee, Victor A. Lopez, Brenden C. Park, Lisa N. Kinch, Sylwia Pilch, Kelly A. Servage, Junmei Zhang, Jenny Jiou, Monika Karasiewicz-Urbańska, Małgorzata Łobocka, Nick V. Grishin, Kim Orth, Roza Kucharczyk, Krzysztof Pawłowski, Diana R. Tomchick, Vincent S. Tagliabracci
      Abstract: The structure of SelO, a conserved pseudokinase, reveals ATP flipped in the substrate binding pocket, leading to the discovery that SelO is actually an AMPylating enzyme.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.046
  • A Neural Circuit for Gut-Induced Reward
    • Authors: Wenfei Han; Luis A. Tellez, Matthew H. Perkins, Isaac O. Perez, Taoran Qu, Jozelia Ferreira, Tatiana L. Ferreira, Daniele Quinn, Zhong-Wu Liu, Xiao-Bing Gao, Melanie M. Kaelberer, Diego V. Bohórquez, Sara J. Shammah-Lagnado, Guillaume de Lartigue, Ivan E. de Araujo
      Abstract: A gut-to-brain neural circuit establishes vagal neurons as an essential component of the reward neuronal pathway, linking sensory neurons in the upper gut to striatal dopamine release.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.049
  • Integration of Parallel Opposing Memories Underlies Memory Extinction
    • Authors: Johannes Felsenberg; Pedro F. Jacob, Thomas Walker, Oliver Barnstedt, Amelia J. Edmondson-Stait, Markus W. Pleijzier, Nils Otto, Philipp Schlegel, Nadiya Sharifi, Emmanuel Perisse, Carlas S. Smith, J. Scott Lauritzen, Marta Costa, Gregory S.X.E. Jefferis, Davi D. Bock, Scott Waddell
      Abstract: The omission of punishment is remembered as a rewarding experience, and this positive memory then competes against prior aversive memory to mediate the extinction of avoidance behavior.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.021
  • Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory
           Bowel Disease
    • Authors: James Kinchen; Hannah H. Chen, Kaushal Parikh, Agne Antanaviciute, Marta Jagielowicz, David Fawkner-Corbett, Neil Ashley, Laura Cubitt, Esther Mellado-Gomez, Moustafa Attar, Eshita Sharma, Quin Wills, Rory Bowden, Felix C. Richter, David Ahern, Kamal D. Puri, Jill Henault, Francois Gervais, Hashem Koohy, Alison Simmons
      First page: 372
      Abstract: Single-cell profiling of human colonic mesenchymal cells identifies a colitis-associated population that expresses factors contributing to epithelial cell dysfunction and inflammation.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.067
  • RAB11FIP5 Expression and Altered Natural Killer Cell Function Are
           Associated with Induction of HIV Broadly Neutralizing Antibody Responses
    • Authors: Todd Bradley; Dimitra Peppa, Isabela Pedroza-Pacheco, Dapeng Li, Derek W. Cain, Ricardo Henao, Vaishnavi Venkat, Bhavna Hora, Yue Chen, Nathan A. Vandergrift, R. Glenn Overman, R. Whitney Edwards, Chris W. Woods, Georgia D. Tomaras, Guido Ferrari, Geoffrey S. Ginsburg, Mark Connors, Myron S. Cohen, M. Anthony Moody, Persephone Borrow, Barton F. Haynes
      First page: 387
      Abstract: Generation of broadly neutralizing antibodies against HIV-1 in humans is linked to the expression of a specific recycling endosome-associated effector in natural killer cells.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.064
  • Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis
    • Authors: Sebastiaan De Schepper; Simon Verheijden, Javier Aguilera-Lizarraga, Maria Francesca Viola, Werend Boesmans, Nathalie Stakenborg, Iryna Voytyuk, Inga Smidt, Bram Boeckx, Isabelle Dierckx de Casterlé, Veerle Baekelandt, Erika Dominguez Gonzalez, Matthias Mack, Inge Depoortere, Bart De Strooper, Ben Sprangers, Uwe Himmelreich, Stefaan Soenen, Martin Guilliams, Pieter Vanden Berghe, Elizabeth Jones, Diether Lambrechts, Guy Boeckxstaens
      First page: 400
      Abstract: A population of self-maintaining macrophages that persists throughout adulthood promotes intestinal homeostasis, contrary to the idea that short-lived monocytes perform this function.
      Citation: Cell (2018)
      PubDate: 2018-08-30
      DOI: 10.1016/j.cell.2018.07.048
  • Evolutionary Pressure against MHC Class II Binding Cancer Mutations
    • Authors: Rachel Marty; Wesley Kurt Thompson, Rany M. Salem, Maurizio Zanetti, Hannah Carter
      First page: 416
      Abstract: Inter-individual variation in MHC-II genotype influences the evolution of patient-specific tumor mutational spectra, emphasizing the key role of CD4+ T cells in anti-tumor immunity.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.048
  • LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune
    • Authors: Larissa D. Cunha; Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. Green
      First page: 429
      Abstract: Impairment of LC3-associated phagocytosis in myeloid cells of the tumor microenvironment has anti-tumor effects.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.061
  • Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic
    • Authors: Giovanni Di Liberto; Stanislav Pantelyushin, Mario Kreutzfeldt, Nicolas Page, Stefano Musardo, Roland Coras, Karin Steinbach, Ilena Vincenti, Bogna Klimek, Thomas Lingner, Gabriela Salinas, Nathalie Lin-Marq, Ori Staszewski, Marta Joana Costa Jordão, Ingrid Wagner, Kristof Egervari, Matthias Mack, Camilla Bellone, Ingmar Blümcke, Marco Prinz, Daniel D. Pinschewer, Doron Merkler
      First page: 458
      Abstract: Neurons act as intermediaries between CD8+ T cells and phagocytes, driving their own synaptic loss during neuroinflammation.
      Citation: Cell (2018)
      PubDate: 2018-08-30
      DOI: 10.1016/j.cell.2018.07.049
  • Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin
    • Authors: Jing Ren; Drew Friedmann, Jing Xiong, Cindy D. Liu, Brielle R. Ferguson, Tanya Weerakkody, Katherine E. DeLoach, Chen Ran, Albert Pun, Yanwen Sun, Brandon Weissbourd, Rachael L. Neve, John Huguenard, Mark A. Horowitz, Liqun Luo
      First page: 472
      Abstract: Two highly complementary parallel serotonergic neuronal pathways in the brain projecting from the dorsal raphe to cortical and subcortical regions of the brain are each activated by reward but show opposite responses to aversive stimuli.
      Citation: Cell (2018)
      PubDate: 2018-08-23
      DOI: 10.1016/j.cell.2018.07.043
  • NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune
    • Authors: Xavier Lahaye; Matteo Gentili, Aymeric Silvin, Cécile Conrad, Léa Picard, Mabel Jouve, Elina Zueva, Mathieu Maurin, Francesca Nadalin, Gavin J. Knott, Baoyu Zhao, Fenglei Du, Marlène Rio, Jeanne Amiel, Archa H. Fox, Pingwei Li, Lucie Etienne, Charles S. Bond, Laurence Colleaux, Nicolas Manel
      First page: 488
      Abstract: The cellular factor NONO activates cGAS-mediated innate immune defenses against HIV-2 infection via viral capsid binding.
      Citation: Cell (2018)
      PubDate: 2018-09-27
      DOI: 10.1016/j.cell.2018.08.062
  • Acetate Production from Glucose and Coupling to Mitochondrial Metabolism
           in Mammals
    • Authors: Xiaojing Liu; Daniel E. Cooper, Ahmad A. Cluntun, Marc O. Warmoes, Steven Zhao, Michael A. Reid, Juan Liu, Peder J. Lund, Mariana Lopes, Benjamin A. Garcia, Kathryn E. Wellen, David G. Kirsch, Jason W. Locasale
      First page: 502
      Abstract: Cells directly produce acetate from pyruvate through two distinct mechanisms, thus providing support for acetyl-CoA pools during times of metabolic deficiency.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.040
  • Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol
           Transport in Mammalian Cells
    • Authors: Jaspreet Sandhu; Shiqian Li, Louise Fairall, Simon G. Pfisterer, Jennifer E. Gurnett, Xu Xiao, Thomas A. Weston, Dipti Vashi, Alessandra Ferrari, Jose L. Orozco, Celine L. Hartman, David Strugatsky, Stephen D. Lee, Cuiwen He, Cynthia Hong, Haibo Jiang, Laurent A. Bentolila, Alberto T. Gatta, Tim P. Levine, Annie Ferng, Richard Lee, David A. Ford, Stephen G. Young, Elina Ikonen, John W.R. Schwabe, Peter Tontonoz
      First page: 514
      Abstract: A nonvesicular pathway for plasma membrane to ER sterol trafficking in mammals is mediated by sterol-binding ER-resident Aster proteins.
      Citation: Cell (2018)
      PubDate: 2018-09-13
      DOI: 10.1016/j.cell.2018.08.033
  • An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and
           Kidney Fibrosis
    • Authors: Ben Roediger; Quintin Lee, Shweta Tikoo, Joanna C.A. Cobbin, James M. Henderson, Mika Jormakka, Matthew B. O’Rourke, Matthew P. Padula, Natalia Pinello, Marisa Henry, Maria Wynne, Sara F. Santagostino, Cory F. Brayton, Lorna Rasmussen, Leszek Lisowski, Szun S. Tay, David C. Harris, John F. Bertram, John P. Dowling, Patrick Bertolino, Jack H. Lai, Wengen Wu, William W. Bachovchin, Justin J.-L. Wong, Mark D. Gorrell, Babak Shaban, Edward C. Holmes, Christopher J. Jolly, Sébastien Monette, Wolfgang Weninger
      First page: 530
      Abstract: A kidney parvovirus found in multiple laboratory mouse colonies causes spontaneous nephropathy and represents a new tool for studying chronic kidney disease.
      Citation: Cell (2018)
      PubDate: 2018-09-13
      DOI: 10.1016/j.cell.2018.08.013
  • Functional Genetic Variants Revealed by Massively Parallel Precise Genome
    • Authors: Eilon Sharon; Shi-An A. Chen, Neil M. Khosla, Justin D. Smith, Jonathan K. Pritchard, Hunter B. Fraser
      First page: 544
      Abstract: A highly efficient Cas9-based method for high-throughput precise genome editing is developed and used to measure the fitness effects of thousands of natural genetic variants in yeast at single-base resolution.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.057
  • Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate
           Transcription-Associated Homologous Recombination Repair
    • Authors: Takaaki Yasuhara; Reona Kato, Yoshihiko Hagiwara, Bunsyo Shiotani, Motohiro Yamauchi, Shinichiro Nakada, Atsushi Shibata, Kiyoshi Miyagawa
      First page: 558
      Abstract: Human Rad52 and R-loop facilitate high-fidelity DNA repair in actively transcribed regions.
      Citation: Cell (2018)
      PubDate: 2018-09-20
      DOI: 10.1016/j.cell.2018.08.056
  • Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and
           Development of the Host via Interaction with ATP Synthase
    • Authors: Bin Qi; Min Han
      First page: 571
      Abstract: Enterobactin, a siderophore produced by the commensal bacterium E. coli, is a key contributor to iron uptake and homeostasis of host cells via its interaction with host ATP synthase.
      Citation: Cell (2018)
      PubDate: 2018-08-23
      DOI: 10.1016/j.cell.2018.07.032
  • A Bacterial Chromosome Structuring Protein Binds Overtwisted DNA to
           Stimulate Type II Topoisomerases and Enable DNA Replication
    • Authors: Monica S. Guo; Diane L. Haakonsen, Wenjie Zeng, Maria A. Schumacher, Michael T. Laub
      First page: 583
      Abstract: A bacterial protein that specifically recognizes and encircles overtwisted DNA is required to stimulate the activity of type II topoisomerases and enable DNA replication.
      Citation: Cell (2018)
      PubDate: 2018-09-13
      DOI: 10.1016/j.cell.2018.08.029
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