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Cell
Journal Prestige (SJR): 25.137
Citation Impact (citeScore): 22
Number of Followers: 1148  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0092-8674 - ISSN (Online) 1097-4172
Published by Elsevier Homepage  [3184 journals]
  • Appreciating What’s Unique about Every Stem Cell
    • Authors: Robert P. Kruger
      First page: 1663
      Abstract: Using single-cell techniques, the behaviors of individual stem cells are coming under ever-greater scrutiny. Such efforts are pushing the boundaries of technology development in cell biology and are getting to the heart of what defines cellular states, what drives cell-state changes, and what can we learn about biological systems from cell-to-cell variability.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.037
      Issue No: Vol. 177, No. 7 (2019)
       
  • Could iPSCs Enable “Off-the-Shelf” Cell Therapy'
    • Authors: Diana Crow
      Pages: 1667 - 1669
      Abstract: An “off-the-shelf” cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs’ self-renewal ability to manufacture cell therapies that don’t require customization for each patient. But some experts aren’t sure such therapies are a good idea.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.043
      Issue No: Vol. 177, No. 7 (2019)
       
  • Developing a Niche in Stem Cell Biology
    • Pages: 1670 - 1671
      Abstract: Vampires, Dracula, Frankenstein. This is often the knee jerk reaction I get from people when describing our research on the rejuvenating effect of young blood on regenerative and cognitive function in the aging brain. Likely it is our experimental approaches that first elicit this response, utilizing a heterochronic parabiosis model (in which a young and old animal are joined) and blood plasma administration paradigms. My interest in the oft-misunderstood field of rejuvenation research, however, is grounded on my fascination with developmental biology and basic questions of plasticity and cell fate.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.038
      Issue No: Vol. 177, No. 7 (2019)
       
  • Surface Sugars Get Cells in Shape
    • Authors: Kamil Godula
      Pages: 1672 - 1674
      Abstract: Cell membranes can adopt a variety of shapes and curvatures, yet our understanding of the factors involved remains limited. In this issue of Cell, Shurer et al. (2019) demonstrate that the glycocalyx can regulate cell shape from the outside in.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.053
      Issue No: Vol. 177, No. 7 (2019)
       
  • Next-Gen Learning: The C. elegans Approach
    • Authors: Amanda G. Charlesworth; Uri Seroussi, Julie M. Claycomb
      Pages: 1674 - 1676
      Abstract: In this issue, Moore et al. and Posner et al., provide evidence for how the activity of the nervous system in C. elegans results in gene expression changes in the germline to pass on parental experiences and learned behavior to their progeny.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.039
      Issue No: Vol. 177, No. 7 (2019)
       
  • Integration of Single-Cell Genomics Datasets
    • Authors: Andrew C. Adey
      Pages: 1677 - 1679
      Abstract: Welch et al. and Stuart et al. present novel techniques for the integration of single-cell RNA-seq datasets across multiple platforms, individuals, and species. They both extend these strategies to map cell types between RNA-seq datasets with epigenetic properties and in situ transcript profiling. The ability to transfer information between datasets and spatial methods will enable more comprehensive profiling and comparisons of cell populations in complex biological systems.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.034
      Issue No: Vol. 177, No. 7 (2019)
       
  • Beginning of a New Era: Mapping the Bone Marrow Niche
    • Authors: Ayako Nakamura-Ishizu; Ben D. MacArthur, Toshio Suda
      Pages: 1679 - 1681
      Abstract: Baryawno et al. provide a comprehensive atlas of the mouse bone marrow stroma based on single-cell RNA-sequencing data. Their analysis reveals a taxonomy of 17 distinct cell types with diverse functions that highlights the complexity of the bone marrow stroma and paves the way for future in vivo assessment.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.042
      Issue No: Vol. 177, No. 7 (2019)
       
  • Autophagy-Independent Functions of the Autophagy Machinery
    • Authors: Lorenzo Galluzzi; Douglas R. Green
      Pages: 1682 - 1699
      Abstract: Proteins that regulate macroautophagy mediate a number of non-autophagy roles in physiology and disease.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.026
      Issue No: Vol. 177, No. 7 (2019)
       
  • Viral Capsid Trafficking along Treadmilling Tubulin Filaments in Bacteria
    • Authors: Vorrapon Chaikeeratisak; Kanika Khanna, Katrina T. Nguyen, Joseph Sugie, MacKennon E. Egan, Marcella L. Erb, Anastasia Vavilina, Poochit Nonejuie, Eliza Nieweglowska, Kit Pogliano, David A. Agard, Elizabeth Villa, Joe Pogliano
      Pages: 1771 - 1780.e12
      Abstract: Bacteriophage-encoded tubulin-like proteins form treadmilling filaments in their bacterial host to transport viral capsids to the subcellular compartment where phage DNA is replicated and transcribed.
      Citation: Cell 177, 7 (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.032
      Issue No: Vol. 177, No. 7 (2019)
       
  • Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful
           Behavior
    • Authors: Yu Mu; Davis V. Bennett, Mikail Rubinov, Sujatha Narayan, Chao-Tsung Yang, Masashi Tanimoto, Brett D. Mensh, Loren L. Looger, Misha B. Ahrens
      Abstract: Whole-brain imaging in virtual-reality-immersed zebrafish reveals that failed swim attempts are detected by noradrenergic neurons, which drive glial cells that accumulate calcium until they trigger the suppression of further futile attempts.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.050
       
  • Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
    • Authors: Simone Rauch; Emily He, Michael Srienc, Huiqing Zhou, Zijie Zhang, Bryan C. Dickinson
      Abstract: Engineered modular RNA-guided RNA-targeting effectors synthesized entirely from human protein parts provide a set of new tools that might overcome the size and immunogenicity limitations of CRISPR-Cas systems.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.049
       
  • STING Polymer Structure Reveals Mechanisms for Activation,
           Hyperactivation, and Inhibition
    • Authors: Sabrina L. Ergun; Daniel Fernandez, Thomas M. Weiss, Lingyin Li
      Abstract: cGAMP binding induces human STING homodimer closing and polymer formation via C-terminal tail release. Disease-causing hyperactive STING mutations affect tail release and STING polymerization, while the bacterial ligand CDG induces an alternative active conformation and acts as a partial inhibitor of cGAMP-mediated STING signaling.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.036
       
  • Atlas of Subcellular RNA Localization Revealed by APEX-Seq
    • Authors: Furqan M. Fazal; Shuo Han, Kevin R. Parker, Pornchai Kaewsapsak, Jin Xu, Alistair N. Boettiger, Howard Y. Chang, Alice Y. Ting
      Abstract: A newly developed technique reveals the subcellular transcriptomes at many landmarks in the nucleus and cytosol and connects mRNA localization to genome architecture, protein location, and local-translation mechanisms.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.027
       
  • Correlated Neural Activity across the Brains of Socially Interacting Bats
    • Authors: Wujie Zhang; Michael M. Yartsev
      Abstract: Social interactions involve complex animal behaviors. In socially interacting bats, there is inter-brain correlation of neural activity, reflecting current and future states of social behavior.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.023
       
  • Correlated Neural Activity and Encoding of Behavior across Brains of
           Socially Interacting Animals
    • Authors: Lyle Kingsbury; Shan Huang, Jun Wang, Ken Gu, Peyman Golshani, Ye Emily Wu, Weizhe Hong
      Abstract: When two animals interact, neural activity across their brains synchronizes in a way that predicts how they will behave and how they form social dominance relationships.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.022
       
  • DNA Microscopy: Optics-free Spatio-genetic Imaging by a Stand-Alone
           Chemical Reaction
    • Authors: Joshua A. Weinstein; Aviv Regev, Feng Zhang
      Abstract: DNA microscopy is an optics-free imaging method based on chemical reactions and a computational algorithm to infer spatial organization of transcripts while simultaneously preserving full sequence information.
      Citation: Cell (2019)
      PubDate: 2019-06-20
      DOI: 10.1016/j.cell.2019.05.019
       
  • Fc Characteristics Mediate Selective Placental Transfer of IgG in
           HIV-Infected Women
    • Authors: David R. Martinez; Youyi Fong, Shuk Hang Li, Fang Yang, Madeleine F. Jennewein, Joshua A. Weiner, Erin A. Harrell, Jesse F. Mangold, Ria Goswami, George R. Seage, Galit Alter, Margaret E. Ackerman, Xinxia Peng, Genevieve G. Fouda, Sallie R. Permar
      Abstract: The impaired transfer of maternal IgG from HIV-infected mothers to their infants is associated with altered binding to Fc receptors FcγRIIa and FcγRIIIa as well as glycan modifications in the Fc region.
      Citation: Cell (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.046
       
  • Fc Glycan-Mediated Regulation of Placental Antibody Transfer
    • Authors: Madeleine F. Jennewein; Ilona Goldfarb, Sepideh Dolatshahi, Cormac Cosgrove, Francesca J. Noelette, Marina Krykbaeva, Jishnu Das, Aniruddh Sarkar, Matthew J. Gorman, Stephanie Fischinger, Carolyn M. Boudreau, Joelle Brown, Jennifer H. Cooperrider, Jasneet Aneja, Todd J. Suscovich, Barney S. Graham, Georg M. Lauer, Tessa Goetghebuer, Arnaud Marchant, Douglas Lauffenburger, Arthur Y. Kim, Laura E. Riley, Galit Alter
      Abstract: Antibodies with a specific glycan modification and with the ability to activate NK cells are selectively transferred across the placenta to the neonate.
      Citation: Cell (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.044
       
  • Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell
           Fate after Chemotherapy
    • Authors: Chien-Hsiang Hsu; Steven J. Altschuler, Lani F. Wu
      Abstract: The proliferation-senescence cell-fate decision after drug treatment is determined by three distinct patterns of p21 dynamics. Either a delayed or acute drug-induced p21 response leads to a senescence fate, while an intermediate pulse of p21 response leads to a proliferation fate. This relation between p21 dynamics and cell fate creates a p21 “Goldilocks zone” that favors cell proliferation after drug treatment.
      Citation: Cell (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.041
       
  • Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome
           Replication
    • Authors: Orly Laufman; John Perrino, Raul Andino
      Abstract: The specialized compartments where enteroviruses replicate are created through membrane contact sites where viral proteins tether host lipid droplets to replication compartments enabling the transfer of fatty acids.
      Citation: Cell (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.030
       
  • Human Antibodies that Slow Erythrocyte Invasion Potentiate
           Malaria-Neutralizing Antibodies
    • Authors: Daniel G.W. Alanine; Doris Quinkert, Rasika Kumarasingha, Shahid Mehmood, Francesca R. Donnellan, Nana K. Minkah, Bernadeta Dadonaite, Ababacar Diouf, Francis Galaway, Sarah E. Silk, Abhishek Jamwal, Jennifer M. Marshall, Kazutoyo Miura, Lander Foquet, Sean C. Elias, Geneviève M. Labbé, Alexander D. Douglas, Jing Jin, Ruth O. Payne, Joseph J. Illingworth, David J. Pattinson, David Pulido, Barnabas G. Williams, Willem A. de Jongh, Gavin J. Wright, Stefan H.I. Kappe, Carol V. Robinson, Carole A. Long, Brendan S. Crabb, Paul R. Gilson, Matthew K. Higgins, Simon J. Draper
      Abstract: Analyses of human monoclonal antibodies against the Plasmodium falciparium protein PfRH5 identify a subset of non-neutralizing antibodies that synergize with a repertoire of other neutralizing antibodies by slowing the ability of malaria-causing parasites to invade red blood cells.
      Citation: Cell (2019)
      PubDate: 2019-06-13
      DOI: 10.1016/j.cell.2019.05.025
       
  • A Small Molecule Targeting Mutagenic Translesion Synthesis Improves
           Chemotherapy
    • Authors: Jessica L. Wojtaszek; Nimrat Chatterjee, Javaria Najeeb, Azucena Ramos, Minhee Lee, Ke Bian, Jenny Y. Xue, Benjamin A. Fenton, Hyeri Park, Deyu Li, Michael T. Hemann, Jiyong Hong, Graham C. Walker, Pei Zhou
      Abstract: A small molecule specifically targeting the mutagenic branch of translesion synthesis binds a nearly featureless surface of REV1 to induce dimerization and block recruitment of POL ζ.
      Citation: Cell (2019)
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.05.028
       
  • Multi-Color Single-Molecule Imaging Uncovers Extensive Heterogeneity in
           mRNA Decoding
    • Authors: Sanne Boersma; Deepak Khuperkar, Bram M.P. Verhagen, Stijn Sonneveld, Jonathan B. Grimm, Luke D. Lavis, Marvin E. Tanenbaum
      Abstract: The MoonTag system is a fluorescence labeling system for visualizing translation of single mRNA molecules in live cells. Combining the MoonTag system with the orthogonal SunTag system enables simultaneous measurements of translation of two open reading frames in an mRNA and reveals that ribosomes differentially decode individual mRNA molecules.
      Citation: Cell (2019)
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.05.001
       
  • A Deep Neural Network for Predicting and Engineering Alternative
           Polyadenylation
    • Authors: Nicholas Bogard; Johannes Linder, Alexander B. Rosenberg, Georg Seelig
      Abstract: A deep neural network enables precise engineering of polyadenylation signals, identifies human genetic variants that act through mis-regulating APA, and learns a comprehensive model of the cis-regulatory APA code.
      Citation: Cell ()
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.04.046
       
  • Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription at
           Single Genes in Live Cells
    • Authors: Jieru Li; Ankun Dong, Kamola Saydaminova, Hill Chang, Guanshi Wang, Hiroshi Ochiai, Takashi Yamamoto, Alexandros Pertsinidis
      Abstract: Key limitations of imaging single copies of highly abundant factors at specific intracellular sites of activity are overcome by an active target-locking system that achieves long-term tracking at single-molecule resolution.
      Citation: Cell (2019)
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.029
       
  • The Translational Landscape of the Human Heart
    • Authors: Sebastiaan van Heesch; Franziska Witte, Valentin Schneider-Lunitz, Jana F. Schulz, Eleonora Adami, Allison B. Faber, Marieluise Kirchner, Henrike Maatz, Susanne Blachut, Clara-Louisa Sandmann, Masatoshi Kanda, Catherine L. Worth, Sebastian Schafer, Lorenzo Calviello, Rhys Merriott, Giannino Patone, Oliver Hummel, Emanuel Wyler, Benedikt Obermayer, Michael B. Mücke, Eric L. Lindberg, Franziska Trnka, Sebastian Memczak, Marcel Schilling, Leanne E. Felkin, Paul J.R. Barton, Nicholas M. Quaife, Konstantinos Vanezis, Sebastian Diecke, Masaya Mukai, Nancy Mah, Su-Jun Oh, Andreas Kurtz, Christoph Schramm, Dorothee Schwinge, Marcial Sebode, Magdalena Harakalova, Folkert W. Asselbergs, Aryan Vink, Roel A. de Weger, Sivakumar Viswanathan, Anissa A. Widjaja, Anna Gärtner-Rommel, Hendrik Milting, Cris dos Remedios, Christoph Knosalla, Philipp Mertins, Markus Landthaler, Martin Vingron, Wolfgang A. Linke, Jonathan G. Seidman, Christine E. Seidman, Nikolaus Rajewsky, Uwe Ohler, Stuart A. Cook, Norbert Hubner
      Abstract: Translational profiling in a primary human tissue reveals frequent translation downstream of predicted disease-causing variants as well as translation of hundreds of microproteins from long noncoding RNAs and circular RNAs.
      Citation: Cell (2019)
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.010
       
  • Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality
           Control
    • Authors: Iryna Lytvynenko; Helge Paternoga, Anna Thrun, Annika Balke, Tina A. Müller, Christina H. Chiang, Katja Nagler, George Tsaprailis, Simon Anders, Ilka Bischofs, Julie A. Maupin-Furlow, Christian M.T. Spahn, Claudio A.P. Joazeiro
      Abstract: Incompletely synthesized proteins (e.g., the products of ribosome stalling during translation) are potentially toxic and must be eliminated. This is a task for Rqc2/NEMF and Ltn1/listerin in the eukaryotic pathway of ribosome-associated protein quality control. Lytvynenko et al. investigate whether prokaryotic Rqc2 homologs function similarly. Their results suggest that organisms in all domains of life have a related, Rqc2-mediated mechanism that extends the C termini of incomplete nascent-chains with peptide sequences (poly-alanine in bacteria) to promote nascent-chain degradation directly or indirectly.
      Citation: Cell (2019)
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.002
       
  • Stromal Microenvironment Shapes the Intratumoral Architecture of
           Pancreatic Cancer
    • Authors: Matteo Ligorio; Srinjoy Sil, Jose Malagon-Lopez, Linda T. Nieman, Sandra Misale, Mauro Di Pilato, Richard Y. Ebright, Murat N. Karabacak, Anupriya S. Kulkarni, Ann Liu, Nicole Vincent Jordan, Joseph W. Franses, Julia Philipp, Johannes Kreuzer, Niyati Desai, Kshitij S. Arora, Mihir Rajurkar, Elad Horwitz, Azfar Neyaz, Eric Tai, Neelima K.C. Magnus, Kevin D. Vo, Chittampalli N. Yashaswini, Francesco Marangoni, Myriam Boukhali, Jackson P. Fatherree, Leah J. Damon, Kristina Xega, Rushil Desai, Melissa Choz, Francesca Bersani, Adam Langenbucher, Vishal Thapar, Robert Morris, Ulrich F. Wellner, Oliver Schilling, Michael S. Lawrence, Andrew S. Liss, Miguel N. Rivera, Vikram Deshpande, Cyril H. Benes, Shyamala Maheswaran, Daniel A. Haber, Carlos Fernandez-Del-Castillo, Cristina R. Ferrone, Wilhelm Haas, Martin J. Aryee, David T. Ting
      Abstract: Clinical outcomes for pancreatic cancer are impacted by intra-tumoral tissue architecture as defined by single-cell analyses and high content digital imaging.
      Citation: Cell ()
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.012
       
  • Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
    • Authors: Weina Zhang; Guihua Wang, Zhi-Gang Xu, Haiqing Tu, Fuqing Hu, Jiang Dai, Yan Chang, Yaqi Chen, Yanjun Lu, Haolong Zeng, Zhen Cai, Fei Han, Chuan Xu, Guoxiang Jin, Li Sun, Bo-Syong Pan, Shiue-Wei Lai, Che-Chia Hsu, Jia Xu, Zhong-Zhu Chen, Hong-Yu Li, Pankaj Seth, Junbo Hu, Xuemin Zhang, Huiyan Li, Hui-Kuan Lin
      Abstract: Lactate acts as a regulator of the adaptor MAVS, allowing a cross-regulation between antiviral signaling and energy metabolism
      Citation: Cell ()
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.003
       
  • Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse
           Behaviors
    • Authors: Marcelo R. Zimmer; Antonio H.O. Fonseca, Onur Iyilikci, Rafael Dai Pra, Marcelo O. Dietrich
      Abstract: Hypothalamic Agrp neurons play a role in offspring-to-caregiver bonding independent of their role in food ingestion.
      Citation: Cell (2019)
      PubDate: 2019-05-16
      DOI: 10.1016/j.cell.2019.04.026
       
  • Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger
           Protective Tumor Immunity
    • Authors: Laurent Gauthier; Ariane Morel, Nadia Anceriz, Benjamin Rossi, Audrey Blanchard-Alvarez, Gwendoline Grondin, Sylvia Trichard, Cédric Cesari, Melody Sapet, Frédéric Bosco, Hélène Rispaud-Blanc, Franceline Guillot, Stéphanie Cornen, Alain Roussel, Béatrice Amigues, Guillaume Habif, Flavien Caraguel, Sandrine Arrufat, Romain Remark, François Romagné, Yannis Morel, Emilie Narni-Mancinelli, Eric Vivier
      First page: 1701
      Abstract: Trifunctional antibodies that engage natural killer cells by binding NKp46 and CD16, in addition to an antigen on cancer cells, show higher potency than current clinically available therapeutic antibodies.
      Citation: Cell (2019)
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.04.041
       
  • Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to
           Chikungunya Virus Envelope Protein
    • Authors: Hao Song; Zhennan Zhao, Yan Chai, Xiyue Jin, Changyao Li, Fei Yuan, Sheng Liu, Zhengrong Gao, Haiyuan Wang, Jian Song, Leonardo Vazquez, Yanfang Zhang, Shuguang Tan, Carlos M. Morel, Jinghua Yan, Yi Shi, Jianxun Qi, Feng Gao, George F. Gao
      First page: 1714
      Abstract: Structural insights into how Chikungunya virus binds its receptor on human cells provides a guide for developing antiviral therapies against arthritogenic alphaviruses.
      Citation: Cell ()
      PubDate: 2019-05-09
      DOI: 10.1016/j.cell.2019.04.008
       
  • Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor
    • Authors: Katherine Basore; Arthur S. Kim, Christopher A. Nelson, Rong Zhang, Brittany K. Smith, Carla Uranga, Lo Vang, Ming Cheng, Michael L. Gross, Jonathan Smith, Michael S. Diamond, Daved H. Fremont
      First page: 1725
      Abstract: Basore et al. describe an X-ray crystal structure of Mxra8, an entry receptor for arthritogenic alphaviruses, and cryo-EM structures of Mxra8 bound to CHIKV. Mxra8 has an unusual Ig-like domain architecture with a head-to-head arrangement, with domain 1 emanating from a loop of domain 2. Mxra8 binds into a complex quaternary cleft formed between two E2-E1 heterodimers within a trimeric spike, while also contacting E1 from a neighboring spike. Mxra8 occupancy is lower when E3 protein is retained on the virion.
      Citation: Cell ()
      PubDate: 2019-05-09
      DOI: 10.1016/j.cell.2019.04.006
       
  • Integrin Mechano-chemical Signaling Generates Plasma Membrane Nanodomains
           that Promote Cell Spreading
    • Authors: Joseph Mathew Kalappurakkal; Anupama Ambika Anilkumar, Chandrima Patra, Thomas S. van Zanten, Michael P. Sheetz, Satyajit Mayor
      First page: 1738
      Abstract: Nanodomains of GPI-anchored proteins at the plasma membrane are constructed downstream of a cytoplasmic machinery triggered by membrane receptor signaling cascade. They are also sensitive to the lipid composition of the membrane. These domains in turn regulate receptor-mediated physiological responses, modulating the functions of the signaling receptor.
      Citation: Cell (2019)
      PubDate: 2019-05-16
      DOI: 10.1016/j.cell.2019.04.037
       
  • Physical Principles of Membrane Shape Regulation by the Glycocalyx
    • Authors: Carolyn R. Shurer; Joe Chin-Hun Kuo, LaDeidra Monét Roberts, Jay G. Gandhi, Marshall J. Colville, Thais A. Enoki, Hao Pan, Jin Su, Jade M. Noble, Michael J. Hollander, John P. O’Donnell, Rose Yin, Kayvon Pedram, Leonhard Möckl, Lena F. Kourkoutis, W.E. Moerner, Carolyn R. Bertozzi, Gerald W. Feigenson, Heidi L. Reesink, Matthew J. Paszek
      First page: 1757
      Abstract: The extracellular glycocalyx can impose forces that bend the plasma membrane and regulate projections and vesicle formation.
      Citation: Cell ()
      PubDate: 2019-05-02
      DOI: 10.1016/j.cell.2019.04.017
       
  • Identification of a DNA N6-Adenine Methyltransferase Complex and Its
           Impact on Chromatin Organization
    • Authors: Leslie Y. Beh; Galia T. Debelouchina, Derek M. Clay, Robert E. Thompson, Kelsi A. Lindblad, Elizabeth R. Hutton, John R. Bracht, Robert P. Sebra, Tom W. Muir, Laura F. Landweber
      First page: 1781
      Abstract: Use of designer eukaryotic chromosomes reveals a role for adenine methylation in nucleosome positioning.
      Citation: Cell (2019)
      PubDate: 2019-05-16
      DOI: 10.1016/j.cell.2019.04.028
       
  • SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
    • Authors: Lea H. Gregersen; Richard Mitter, Alejandro P. Ugalde, Takayuki Nojima, Nicholas J. Proudfoot, Reuven Agami, Aengus Stewart, Jesper Q. Svejstrup
      First page: 1797
      Abstract: Eukaryotic anti-terminator proteins suppress usage of early polyadenylation sites to prevent production of truncated proteins.
      Citation: Cell (2019)
      PubDate: 2019-05-16
      DOI: 10.1016/j.cell.2019.04.038
       
  • Neuronal Small RNAs Control Behavior Transgenerationally
    • Authors: Rachel Posner; Itai Antoine Toker, Olga Antonova, Ekaterina Star, Sarit Anava, Eran Azmon, Michael Hendricks, Shahar Bracha, Hila Gingold, Oded Rechavi
      First page: 1814
      Abstract: The idea that brain activity can impact the fate of the progeny goes against a central tenet of biology. Posner et al. describe an RNA-based mechanism for how neuronal responses to environmental cues can be translated into heritable information that affects the behavior of progeny.
      Citation: Cell (2019)
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.04.029
       
  • Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned
           Pathogenic Avoidance
    • Authors: Rebecca S. Moore; Rachel Kaletsky, Coleen T. Murphy
      First page: 1827
      Abstract: Worms can transmit avoidance behavior to their young for four generations, providing progeny with a mechanism to survive dangerous conditions.
      Citation: Cell (2019)
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.05.024
       
  • Tracing Oncogene Rearrangements in the Mutational History of Lung
           Adenocarcinoma
    • Authors: Jake June-Koo Lee; Seongyeol Park, Hansol Park, Sehui Kim, Jongkeun Lee, Junehawk Lee, Jeonghwan Youk, Kijong Yi, Yohan An, In Kyu Park, Chang Hyun Kang, Doo Hyun Chung, Tae Min Kim, Yoon Kyung Jeon, Dongwan Hong, Peter J. Park, Young Seok Ju, Young Tae Kim
      First page: 1842
      Abstract: Driver fusion oncogenes in human lung adenocarcinoma of non-smokers are generated from complex genomic rearrangements and often arise in early decades of life, long before diagnosable disease.
      Citation: Cell ()
      PubDate: 2019-05-30
      DOI: 10.1016/j.cell.2019.05.013
       
  • Area-Specificity and Plasticity of History-Dependent Value Coding During
           Learning
    • Authors: Ryoma Hattori; Bethanny Danskin, Zeljana Babic, Nicole Mlynaryk, Takaki Komiyama
      First page: 1858
      Abstract: During decision making, values formed through experience are flexibly yet persistently maintained in the retrosplenial cortex over time to support adaptive behaviors.
      Citation: Cell ()
      PubDate: 2019-05-09
      DOI: 10.1016/j.cell.2019.04.027
       
  • Single-Cell Multi-omic Integration Compares and Contrasts Features of
           Brain Cell Identity
    • Authors: Joshua D. Welch; Velina Kozareva, Ashley Ferreira, Charles Vanderburg, Carly Martin, Evan Z. Macosko
      First page: 1873
      Abstract: A platform called LIGER allows for the integration of gene expression, epigenetic regulation, and spatial relationships across single-cell datasets.
      Citation: Cell (2019)
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.05.006
       
  • Comprehensive Integration of Single-Cell Data
    • Authors: Tim Stuart; Andrew Butler, Paul Hoffman, Christoph Hafemeister, Efthymia Papalexi, William M. Mauck, Yuhan Hao, Marlon Stoeckius, Peter Smibert, Rahul Satija
      First page: 1888
      Abstract: A computational approach to integrate diverse modalities associated with single-cell sequencing datasets can be used to better understand cellular identity and function.
      Citation: Cell ()
      PubDate: 2019-06-06
      DOI: 10.1016/j.cell.2019.05.031
       
  • Visualizing Engrafted Human Cancer and Therapy Responses in
           Immunodeficient Zebrafish
    • Authors: Chuan Yan; Dalton C. Brunson, Qin Tang, Daniel Do, Nicolae A. Iftimia, John C. Moore, Madeline N. Hayes, Alessandra M. Welker, Elaine G. Garcia, Taronish D. Dubash, Xin Hong, Benjamin J. Drapkin, David T. Myers, Sarah Phat, Angela Volorio, Dieuwke L. Marvin, Matteo Ligorio, Lyle Dershowitz, Karin M. McCarthy, Murat N. Karabacak, Jonathan A. Fletcher, Dennis C. Sgroi, John A. Iafrate, Shyamala Maheswaran, Nick J. Dyson, Daniel A. Haber, John F. Rawls, David M. Langenau
      First page: 1903
      Abstract: Robust engraftment of human cancers into optically-clear, immune-deficient zebrafish at physiological temperatures enables dynamic visualization of cell biological phenotypes and therapy responses in single cancer cells over time.
      Citation: Cell (2019)
      PubDate: 2019-04-25
      DOI: 10.1016/j.cell.2019.04.004
       
  • A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia
    • Authors: Ninib Baryawno; Dariusz Przybylski, Monika S. Kowalczyk, Youmna Kfoury, Nicolas Severe, Karin Gustafsson, Konstantinos D. Kokkaliaris, Francois Mercier, Marcin Tabaka, Matan Hofree, Danielle Dionne, Ani Papazian, Dongjun Lee, Orr Ashenberg, Ayshwarya Subramanian, Eeshit Dhaval Vaishnav, Orit Rozenblatt-Rosen, Aviv Regev, David T. Scadden
      First page: 1915
      Abstract: Molecular definition of the cell populations comprising bone marrow stroma is provided with single-cell resolution. Seventeen distinct cell subsets with new mesenchymal, pericyte, fibroblast, and endothelial subpopulations, new inferred osteolineage differentiation trajectories, and distinctions among Lepr, Nestin, and NG2-expressing HSC niche populations are defined. The changes imposed by an emergent AML indicate impaired stromal differentiation among mesenchymal cells and decreased expression of hematopoietic regulatory genes consistent with cancer cells indirectly impairing the normal hematopoietic cells with whom they must compete.
      Citation: Cell (2019)
      PubDate: 2019-05-23
      DOI: 10.1016/j.cell.2019.04.040
       
  • Illuminating G-Protein-Coupling Selectivity of GPCRs
    • Authors: Asuka Inoue; Francesco Raimondi, Francois Marie Ngako Kadji, Gurdeep Singh, Takayuki Kishi, Akiharu Uwamizu, Yuki Ono, Yuji Shinjo, Satoru Ishida, Nadia Arang, Kouki Kawakami, J. Silvio Gutkind, Junken Aoki, Robert B. Russell
      First page: 1933
      Abstract: A large-scale functional interaction study reveals how GPCRs engage with subsets of G(alpha) proteins and outlines characteristic predictive of these associations.
      Citation: Cell (2019)
      PubDate: 2019-05-31
      DOI: 10.1016/j.cell.2019.04.044
       
  • Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of
           Associative Learning
    • Authors: Annie Handler; Thomas G.W. Graham, Raphael Cohn, Ianessa Morantte, Andrew F. Siliciano, Jianzhi Zeng, Yulong Li, Vanessa Ruta
      Abstract: Olfactory associations are formed and updated on a trial-by-trial basis depending on the timing of the odor presentation and reinforcement mediated by two dopamine receptor signaling pathways that play opposing roles in directing synaptic and behavioral plasticity in Drosophila.
      Citation: Cell ()
      DOI: 10.1016/j.cell.2019.05.040
       
 
 
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