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Journal Cover The Lancet
  [SJR: 14.638]   [H-I: 600]   [2112 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 0140-6736 - ISSN (Online) 1474-547X
   Published by Elsevier Homepage  [3044 journals]
  • Treatment of Duchenne muscular dystrophy: first small steps
    • Authors: Claire L Wood; Tim Cheetham
      Pages: 1467 - 1468
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Claire L Wood, Tim Cheetham


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31669-0
       
  • Long-acting injectable ART: next revolution in HIV'
    • Authors: Mark A Boyd; David A Cooper
      Pages: 1468 - 1470
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Mark A Boyd, David A Cooper


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31962-1
       
  • Is there a future for mRNAs as viral vaccines'
    • Authors: Mary Warrell
      Pages: 1470 - 1471
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Mary Warrell


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31964-5
       
  • Health inequality across prefectures in Japan
    • Authors: Churnrurtai Kanchanachitra; Viroj Tangcharoensathien
      Pages: 1471 - 1473
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Churnrurtai Kanchanachitra, Viroj Tangcharoensathien


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31792-0
       
  • Beating NCDs can help deliver universal health coverage
    • Authors: Tabaré Ramón Vázquez; Tedros Adhanom Ghebreyesus
      Pages: 1473 - 1474
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Tabaré Ramón Vázquez, Tedros Adhanom Ghebreyesus


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32470-4
       
  • Where is the accountability to adolescents'
    • Authors: Carmen Barroso; Kul Chandra Gautam
      Pages: 1474 - 1475
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Carmen Barroso, Kul Chandra Gautam


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32482-0
       
  • Offline: The post-American age
    • Authors: Richard Horton
      First page: 1476
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Richard Horton


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32512-6
       
  • Health in Angola in the wake of the presidential election
    • Authors: Andrew Green
      Pages: 1477 - 1478
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Andrew Green


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32515-1
       
  • Lasker foundation announces award winners for 2017
    • Authors: Talha Burki
      Pages: 1479 - 1480
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Talha Burki


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32380-2
       
  • Going “round the bend” in prisoner of war camps
    • Authors: Clare Makepeace
      Pages: 1483 - 1484
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Clare Makepeace


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32439-x
       
  • Hepatitis B and C in Tonkolili Province, Sierra Leone
    • Authors: Noemi García-Tardón; Tom M Gresnigt; Abu B Fofanah; Martin P Grobusch
      First page: 1485
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Noemi García-Tardón, Tom M Gresnigt, Abu B Fofanah, Martin P Grobusch


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32390-5
       
  • Mainstreaming genomic medicine
    • Authors: David Bourn
      First page: 1486
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): David Bourn


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32391-7
       
  • Exclusive and partial enteral nutrition for Crohn's disease
    • Authors: Nizar H Senussi
      First page: 1486
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Nizar H Senussi


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32392-9
       
  • Exclusive and partial enteral nutrition for Crohn's disease –
           Authors' reply
    • Authors: Subra Kugathasan; Lee A Denson; Jeffrey S Hyams
      Pages: 1486 - 1487
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Subra Kugathasan, Lee A Denson, Jeffrey S Hyams


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32157-8
       
  • Head injury decision rules in children
    • Authors: Martin H Osmond
      First page: 1487
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Martin H Osmond


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32150-5
       
  • Head injury decision rules in children
    • Authors: Nathan Kuppermann; James F Holmes; Peter S Dayan
      Pages: 1487 - 1488
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Nathan Kuppermann, James F Holmes, Peter S Dayan


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32153-0
       
  • Head injury decision rules in children – Authors' reply
    • Authors: Franz E Babl; Ed Oakley; Meredith L Borland; Silvia Bressan; Stuart R Dalziel
      First page: 1488
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Franz E Babl, Ed Oakley, Meredith L Borland, Silvia Bressan, Stuart R Dalziel


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32164-5
       
  • Long-acting intramuscular cabotegravir and rilpivirine in adults with
           HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label,
           phase 2b, non-inferiority trial
    • Authors: David A Margolis; Juan Gonzalez-Garcia; Hans-Jürgen Stellbrink; Joseph J Eron; Yazdan Yazdanpanah; Daniel Podzamczer; Thomas Lutz; Jonathan B Angel; Gary J Richmond; Bonaventura Clotet; Felix Gutierrez; Louis Sloan; Marty St Clair; Miranda Murray; Susan L Ford; Joseph Mrus; Parul Patel; Herta Crauwels; Sandy K Griffith; Kenneth C Sutton; David Dorey; Kimberly Y Smith; Peter E Williams; William R Spreen
      Pages: 1499 - 1510
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): David A Margolis, Juan Gonzalez-Garcia, Hans-Jürgen Stellbrink, Joseph J Eron, Yazdan Yazdanpanah, Daniel Podzamczer, Thomas Lutz, Jonathan B Angel, Gary J Richmond, Bonaventura Clotet, Felix Gutierrez, Louis Sloan, Marty St Clair, Miranda Murray, Susan L Ford, Joseph Mrus, Parul Patel, Herta Crauwels, Sandy K Griffith, Kenneth C Sutton, David Dorey, Kimberly Y Smith, Peter E Williams, William R Spreen
      Background Cabotegravir and rilpivirine are antiretroviral drugs in development as long-acting injectable formulations. The LATTE-2 study evaluated long-acting cabotegravir plus rilpivirine for maintenance of HIV-1 viral suppression through 96 weeks. Methods In this randomised, phase 2b, open-label study, treatment-naive adults infected with HIV-1 initially received oral cabotegravir 30 mg plus abacavir–lamivudine 600–300 mg once daily. The objective of this study was to select an intramuscular dosing regimen based on a comparison of the antiviral activity, tolerability, and safety of the two intramuscular dosing regimens relative to oral cabotegravir plus abacavir–lamivudine. After a 20-week induction period on oral cabotegravir plus abacavir–lamivudine, patients with viral suppression (plasma HIV-1 RNA <50 copies per mL) were randomly assigned (2:2:1) to intramuscular long-acting cabotegravir plus rilpivirine at 4-week intervals (long-acting cabotegravir 400 mg plus rilpivirine 600 mg; two 2 mL injections) or 8-week intervals (long-acting cabotegravir 600 mg plus rilpivirine 900 mg; two 3 mL injections) or continued oral cabotegravir plus abacavir–lamivudine. Randomisation was computer-generated with stratification by HIV-1 RNA (<50 copies per mL, yes or no) during the first 12 weeks of the induction period. The primary endpoints were the proportion of patients with viral suppression at week 32 (as defined by the US Food and Drug Administration snapshot algorithm), protocol-defined virological failures, and safety events through 96 weeks. All randomly assigned patients who received at least one dose of study drug during the maintenance period were included in the primary efficacy and safety analyses. The primary analysis used a Bayesian approach to evaluate the hypothesis that the proportion with viral suppression for each long-acting regimen is not worse than the oral regimen proportion by more than 10% (denoted comparable) according to a prespecified decision rule (ie, posterior probability for comparability >90%). Difference in proportions and associated 95% CIs were supportive to the primary analysis. The trial is registered at ClinicalTrials.gov, number NCT02120352. Findings Among 309 enrolled patients, 286 were randomly assigned to the maintenance period (115 to each of the 4-week and 8-week groups and 56 to the oral treatment group). This study is currently ongoing. At 32 weeks following randomisation, both long-acting regimens met primary criteria for comparability in viral suppression relative to the oral comparator group. Viral suppression was maintained at 32 weeks in 51 (91%) of 56 patients in the oral treatment group, 108 (94%) of 115 patients in the 4-week group (difference 2·8% [95% CI −5·8 to 11·5] vs oral treatment), and 109 (95%) of 115 patients in the 8-week group (difference 3·7% [−4·8 to 12·2] vs oral treatment). At week 96, viral suppression was maintained in 47 (84%) of 56 patients receiving oral treatment, 100 (87%) of 115 patients in the 4-week group, and 108 (94%) of 115 patients in the 8-week group. Three patients (1%) experienced protocol-defined virological failure (two in the 8-week group; one in the oral treatment group). Injection-site reactions were mild (3648 [84%] of 4360 injections) or moderate (673 [15%] of 4360 injections) in intensity and rarely resulted in discontinuation (two [<1%] of 230 patients); injection-site pain was reported most frequently. Serious adverse events during maintenance were reported in 22 (10%) of 230 patients in the intramuscular groups (4-week and 8-week groups) and seven (13%) of 56 patients in the oral treatment group; none were drug related. Interpretation The two-drug combination of all-injectable, long-acting cabotegravir plus rilpivirine every 4 weeks or every 8 weeks was as effective as daily three-drug oral therapy at maintaining HIV-1 viral suppression through 96 weeks and was well accepted and tolerated.
      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31917-7
       
  • Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an
           open-label, non-randomised, prospective, first-in-human phase 1 clinical
           trial
    • Authors: Martin Alberer; Ulrike Gnad-Vogt; Henoch Sangjoon Hong; Keyvan Tadjalli Mehr; Linus Backert; Greg Finak; Raphael Gottardo; Mihai Alexandru Bica; Aurelio Garofano; Sven Dominik Koch; Mariola Fotin-Mleczek; Ingmar Hoerr; Ralf Clemens; Frank von Sonnenburg
      Pages: 1511 - 1520
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Martin Alberer, Ulrike Gnad-Vogt, Henoch Sangjoon Hong, Keyvan Tadjalli Mehr, Linus Backert, Greg Finak, Raphael Gottardo, Mihai Alexandru Bica, Aurelio Garofano, Sven Dominik Koch, Mariola Fotin-Mleczek, Ingmar Hoerr, Ralf Clemens, Frank von Sonnenburg
      Background Vaccines based on mRNA coding for antigens have been shown to be safe and immunogenic in preclinical models. We aimed to report results of the first-in-human proof-of-concept clinical trial in healthy adults of a prophylactic mRNA-based vaccine encoding rabies virus glycoprotein (CV7201). Methods We did an open-label, uncontrolled, prospective, phase 1 clinical trial at one centre in Munich, Germany. Healthy male and female volunteers (aged 18–40 years) with no history of rabies vaccination were sequentially enrolled. They received three doses of CV7201 intradermally or intramuscularly by needle-syringe or one of three needle-free devices. Escalating doses were given to subsequent cohorts, and one cohort received a booster dose after 1 year. The primary endpoint was safety and tolerability. The secondary endpoint was to determine the lowest dose of CV7201 to elicit rabies virus neutralising titres equal to or greater than the WHO-specified protective antibody titre of 0·5 IU/mL. The study is continuing for long-term safety and immunogenicity follow-up. This trial is registered with ClinicalTrials.gov, number NCT02241135. Findings Between Oct 21, 2013, and Jan 11, 2016, we enrolled and vaccinated 101 participants with 306 doses of mRNA (80–640 μg) by needle-syringe (18 intradermally and 24 intramuscularly) or needle-free devices (46 intradermally and 13 intramuscularly). In the 7 days post vaccination, 60 (94%) of 64 intradermally vaccinated participants and 36 (97%) of 37 intramuscularly vaccinated participants reported solicited injection site reactions, and 50 (78%) of 64 intradermally vaccinated participants and 29 (78%) of 37 intramuscularly vaccinated participants reported solicited systemic adverse events, including ten grade 3 events. One unexpected, possibly related, serious adverse reaction that occurred 7 days after a 640 μg intramuscular dose resolved without sequelae. mRNA vaccination by needle-free intradermal or intramuscular device injection induced virus neutralising antibody titres of 0·5 IU/mL or more across dose levels and schedules in 32 (71%) of 45 participants given 80 μg or 160 μg CV7201 doses intradermally and six (46%) of 13 participants given 200 μg or 400 μg CV7201 doses intramuscularly. 1 year later, eight (57%) of 14 participants boosted with an 80 μg needle-free intradermal dose of CV7201 achieved titres of 0·5 IU/mL or more. Conversely, intradermal or intramuscular needle-syringe injection was ineffective, with only one participant (who received 320 μg intradermally) showing a detectable immune response. Interpretation This first-ever demonstration in human beings shows that a prophylactic mRNA-based candidate vaccine can induce boostable functional antibodies against a viral antigen when administered with a needle-free device, although not when injected by a needle-syringe. The vaccine was generally safe with a reasonable tolerability profile. Funding CureVac AG.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31665-3
       
  • Population health and regional variations of disease burden in Japan,
           1990–2015: a systematic subnational analysis for the Global Burden of
           Disease Study 2015
    • Authors: Shuhei Nomura; Haruka Sakamoto; Scott Glenn; Yusuke Tsugawa; Sarah K Abe; Md M Rahman; Jonathan C Brown; Satoshi Ezoe; Christina Fitzmaurice; Tsuyoshi Inokuchi; Nicholas J Kassebaum; Norito Kawakami; Yosuke Kita; Naoki Kondo; Stephen S Lim; Satoshi Maruyama; Hiroaki Miyata; Meghan D Mooney; Mohsen Naghavi; Tomoko Onoda; Erika Ota; Yuji Otake; Gregory A Roth; Eiko Saito; Takahiro Tabuchi; Yohsuke Takasaki; Tadayuki Tanimura; Manami Uechi; Theo Vos; Haidong Wang; Manami Inoue; Christopher J L Murray; Kenji Shibuya
      Pages: 1521 - 1538
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Shuhei Nomura, Haruka Sakamoto, Scott Glenn, Yusuke Tsugawa, Sarah K Abe, Md M Rahman, Jonathan C Brown, Satoshi Ezoe, Christina Fitzmaurice, Tsuyoshi Inokuchi, Nicholas J Kassebaum, Norito Kawakami, Yosuke Kita, Naoki Kondo, Stephen S Lim, Satoshi Maruyama, Hiroaki Miyata, Meghan D Mooney, Mohsen Naghavi, Tomoko Onoda, Erika Ota, Yuji Otake, Gregory A Roth, Eiko Saito, Takahiro Tabuchi, Yohsuke Takasaki, Tadayuki Tanimura, Manami Uechi, Theo Vos, Haidong Wang, Manami Inoue, Christopher J L Murray, Kenji Shibuya
      Background Japan has entered the era of super-ageing and advanced health transition, which is increasingly putting pressure on the sustainability of its health system. The level and pace of this health transition might vary across regions within Japan and concern is growing about increasing regional variations in disease burden. The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) provides a comprehensive, comparable framework. We used data from GBD 2015 with the aim to quantify the burden of disease and injuries, and to attribute risk factors in Japan at a subnational, prefecture-level. Methods We used data from GBD 2015 for 315 causes and 79 risk factors of death, disease, and injury incidence and prevalence to measure the burden of diseases and injuries in Japan and in the 47 Japanese prefectures from 1990 to 2015. We extracted data from GBD 2015 to assess mortality, causes of death, years of life lost (YLLs), years lived with disability (YLDs), disability-adjusted life-years (DALYs), life expectancy, and healthy life expectancy (HALE) in Japan and its 47 prefectures. We split extracted data by prefecture and applied GBD methods to generate estimates of burden, and attributable burden due to known risk factors. We examined the prefecture-level relationships of common health system inputs (eg, health expenditure and workforces) to the GBD outputs in 2015 to address underlying determinants of regional health variations. Findings Life expectancy at birth in Japan increased by 4·2 years from 79·0 years (95% uncertainty interval [UI] 79·0 to 79·0) to 83·2 years (83·1 to 83·2) between 1990 and 2015. However, the gaps between prefectures with the lowest and highest life expectancies and HALE have widened, from 2·5 to 3·1 years and from 2·3 to 2·7 years, respectively, from 1990 to 2015. Although overall age-standardised death rates decreased by 29·0% (28·7 to 29·3) from 1990 to 2015, the rates of mortality decline in this period substantially varied across the prefectures, ranging from −32·4% (−34·8 to −30·0) to −22·0% (−20·4 to −20·1). During the same time period, the rate of age-standardised DALYs was reduced overall by 19·8% (17·9 to 22·0). The reduction in rates of age-standardised YLDs was very small by 3·5% (2·6 to 4·3). The pace of reduction in mortality and DALYs in many leading causes has largely levelled off since 2005. Known risk factors accounted for 34·5% (32·4 to 36·9) of DALYs; the two leading behavioural risk factors were unhealthy diets and tobacco smoking in 2015. The common health system inputs were not associated with age-standardised death and DALY rates in 2015. Interpretation Japan has been successful overall in reducing mortality and disability from most major diseases. However, progress has slowed down and health variations between prefectures is growing. In view of the limited association between the prefecture-level health system inputs and health outcomes, the potential sources of regional variations, including subnational health system performance, urgently need assessment. Funding Bill & Melinda Gates Foundation, Japan Ministry of Education, Science, Sports and Culture, Japan Ministry of Health, Labour and Welfare, AXA CR Fixed Income Fund and AXA Research Fund.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31544-1
       
  • Hypothyroidism
    • Authors: Layal Chaker; Antonio C Bianco; Jacqueline Jonklaas; Robin P Peeters
      Pages: 1550 - 1562
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Layal Chaker, Antonio C Bianco, Jacqueline Jonklaas, Robin P Peeters
      Hypothyroidism is a common condition of thyroid hormone deficiency, which is readily diagnosed and managed but potentially fatal in severe cases if untreated. The definition of hypothyroidism is based on statistical reference ranges of the relevant biochemical parameters and is increasingly a matter of debate. Clinical manifestations of hypothyroidism range from life threatening to no signs or symptoms. The most common symptoms in adults are fatigue, lethargy, cold intolerance, weight gain, constipation, change in voice, and dry skin, but clinical presentation can differ with age and sex, among other factors. The standard treatment is thyroid hormone replacement therapy with levothyroxine. However, a substantial proportion of patients who reach biochemical treatment targets have persistent complaints. In this Seminar, we discuss the epidemiology, causes, and symptoms of hypothyroidism; summarise evidence on diagnosis, long-term risk, treatment, and management; and highlight future directions for research.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)30703-1
       
  • For universal health coverage, tomorrow is today
    • Authors: Lancet
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • Last days of the Rohingya of Rakhine
    • Authors: Lancet
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • An annual spotlight on Australian general practice
    • Authors: Lancet
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • Department of Error
    • Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101


      PubDate: 2017-09-23T11:20:59Z
       
  • Ataluren in patients with nonsense mutation Duchenne muscular dystrophy
           (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled,
           phase 3 trial
    • Authors: Craig McDonald; Craig Campbell Ricardo Erazo Torricelli Richard Finkel Kevin
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): Craig M McDonald, Craig Campbell, Ricardo Erazo Torricelli, Richard S Finkel, Kevin M Flanigan, Nathalie Goemans, Peter Heydemann, Anna Kaminska, Janbernd Kirschner, Francesco Muntoni, Andrés Nascimento Osorio, Ulrike Schara, Thomas Sejersen, Perry B Shieh, H Lee Sweeney, Haluk Topaloglu, Már Tulinius, Juan J Vilchez, Thomas Voit, Brenda Wong, Gary Elfring, Hans Kroger, Xiaohui Luo, Joseph McIntosh, Tuyen Ong, Peter Riebling, Marcio Souza, Robert J Spiegel, Stuart W Peltz, Eugenio Mercuri
      Background Duchenne muscular dystrophy (DMD) is a severe, progressive, and rare neuromuscular, X-linked recessive disease. Dystrophin deficiency is the underlying cause of disease; therefore, mutation-specific therapies aimed at restoring dystrophin protein production are being explored. We aimed to assess the efficacy and safety of ataluren in ambulatory boys with nonsense mutation DMD. Methods We did this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial at 54 sites in 18 countries located in North America, Europe, the Asia-Pacific region, and Latin America. Boys aged 7–16 years with nonsense mutation DMD and a baseline 6-minute walk distance (6MWD) of 150 m or more and 80% or less of the predicted normal value for age and height were randomly assigned (1:1), via permuted block randomisation (block size of four) using an interactive voice-response or web-response system, to receive ataluren orally three times daily (40 mg/kg per day) or matching placebo. Randomisation was stratified by age (<9 years vs ≥9 years), duration of previous corticosteroid use (6 months to <12 months vs ≥12 months), and baseline 6MWD (<350 m vs ≥350 m). Patients, parents and caregivers, investigational site personnel, PTC Therapeutics employees, and all other study personnel were masked to group allocation until after database lock. The primary endpoint was change in 6MWD from baseline to week 48. We additionally did a prespecified subgroup analysis of the primary endpoint, based on baseline 6MWD, which is reflective of anticipated rates of disease progression over 1 year. The primary analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01826487. Findings Between March 26, 2013, and Aug 26, 2014, we randomly assigned 230 patients to receive ataluren (n=115) or placebo (n=115); 228 patients comprised the intention-to-treat population. The least-squares mean change in 6MWD from baseline to week 48 was −47·7 m (SE 9·3) for ataluren-treated patients and −60·7 m (9·3) for placebo-treated patients (difference 13·0 m [SE 10·4], 95% CI −7·4 to 33·4; p=0·213). The least-squares mean change for ataluren versus placebo in the prespecified subgroups was −7·7 m (SE 24·1, 95% CI −54·9 to 39·5; p=0·749) in the group with a 6MWD of less than 300 m, 42·9 m (15·9, 11·8–74·0; p=0·007) in the group with a 6MWD of 300 m or more to less than 400 m, and −9·5 m (17·2, −43·2 to 24·2; p=0·580) in the group with a 6MWD of 400 m or more. Ataluren was generally well tolerated and most treatment-emergent adverse events were mild to moderate in severity. Eight (3%) patients (n=4 per group) reported serious adverse events; all except one event in the placebo group (abnormal hepatic function deemed possibly related to treatment) were deemed unrelated to treatment. Interpretation Change in 6MWD did not differ significantly between patients in the ataluren group and those in the placebo group, neither in the intention-to-treat population nor in the prespecified subgroups with a baseline 6MWD of less than 300 m or 400 m or more. However, we recorded a significant effect of ataluren in the prespecified subgroup of patients with a baseline 6MWD of 300 m or more to less than 400 m. Baseline 6MWD values within this range were associated with a more predictable rate of decline over 1 year; this finding has implications for the design of future DMD trials with the 6-minute walk test as the endpoint. Funding
      PubDate: 2017-09-23T11:20:59Z
       
  • Cholera
    • Authors: John Clemens; Balakrish Nair Tahmeed Ahmed Firdausi Qadri Jan Holmgren
      Abstract: Publication date: 23–29 September 2017
      Source:The Lancet, Volume 390, Issue 10101
      Author(s): John D Clemens, G Balakrish Nair, Tahmeed Ahmed, Firdausi Qadri, Jan Holmgren
      Cholera is an acute, watery diarrhoeal disease caused by Vibrio cholerae of the O1 or O139 serogroups. In the past two centuries, cholera has emerged and spread from the Ganges Delta six times and from Indonesia once to cause global pandemics. Rational approaches to the case management of cholera with oral and intravenous rehydration therapy have reduced the case fatality of cholera from more than 50% to much less than 1%. Despite improvements in water quality, sanitation, and hygiene, as well as in the clinical treatment of cholera, the disease is still estimated to cause about 100 000 deaths every year. Most deaths occur in cholera-endemic settings, and virtually all deaths occur in developing countries. Contemporary understanding of immune protection against cholera, which results from local intestinal immunity, has yielded safe and protective orally administered cholera vaccines that are now globally stockpiled for use in the control of both epidemic and endemic cholera.

      PubDate: 2017-09-23T11:20:59Z
       
  • Efficiency and safety of varying the frequency of whole blood donation
           (INTERVAL): a randomised trial of 45 000 donors
    • Authors: Emanuele Di Angelantonio; Simon G Thompson; Stephen Kaptoge; Carmel Moore; Matthew Walker; Jane Armitage; Willem H Ouwehand; David J Roberts; John Danesh; Emanuele Di Angelantonio; Simon G Thompson; Stephen Kaptoge; Carmel Moore; Matthew Walker; Jane Armitage; Willem H Ouwehand; David J Roberts; John Danesh; Jane Armitage; John Danesh; Emanuele Di Angelantonio; Jenny Donovan; Ian Ford; Rachel Henry; Beverley J Hunt; Bridget Le Huray; Susan Mehenny; Gail Miflin; Carmel Moore; Willem H Ouwehand; Jane Green; David J Roberts; Mike Stredder; Simon G Thompson; Matthew Walker; Nicholas A Watkins; Alan McDermott; Clive Ronaldson; Claire Thomson; Zoe Tolkien; Lorna Williamson; David Allen; John Danesh; Emanuele Di Angelantonio; Rachel Henry; Susan Mehenny; Carmel Moore; Willem H Ouwehand; David J Roberts; Jennifer Sambrook; Matthew Walker; Tracey Hammerton; Claire Thomson; Zoe Tolkien; David Allen; David Bruce; Fizzah Choudry; Emanuele Di Angelantonio; Cedric Ghevaert; Kirstie Johnston; Anne Kelly; Andrew King; Susan Mehenny; Gail Miflin; Alfred Mo; Carmel Moore; Willem H Ouwehand; Lizanne Page; Penny Richardson; David J Roberts; Jennifer Sambrook; Peter Senior; Yagnesh Umrania; Matthew Walker; Henna Wong; Stephen Kaptoge; Gavin Murphy; Adrian C Newland; Keith Wheatley; Michael Greaves; Marc Turner; Tahir Aziz; Richard Brain; Christine Davies; Ruth Turner; Paula Wakeman; Alison Dent; Alan Wakeman; Ben Anthony; Desmond Bland; Will Parrondo; Helen Vincent; Candy Weatherill; Andrea Forsyth; Carol Butterfield; Tracey Wright; Karen Ellis; Kirstie Johnston; Pat Poynton; Carolyn Brooks; Emma Martin; Lara Littler; Lindsay Williams; Donna Blair; Karen Ackerley; Lynn Woods; Sophie Stanley; Gemma Walsh; Gayle Franklin; Cheryl Howath; Sarah Sharpe; Deborah Smith; Lauren Botham; Caroline Williams; Claire Alexander; Gareth Sowerbutts; Diane Furnival; Michael Thake; Shilpa Patel; Carolyn Roost; Sandra Sowerby; Mary Joy Appleton; Eileen Bays; Geoff Bowyer; Steven Clarkson; Stuart Halson; Kate Holmes; Gareth Humphries; Kirstie Johnston; Lee Parvin-Cooper; Jason Towler; Joanne Addy; Patricia Barrass; Louise Stennett; Susan Burton; Hannah Dingwall; Rachel Henry; Victoria Clarke; Maria Potton; Claire Thomson; Thomas Bolton; Michael Daynes; Stuart Halson; Sarah Spackman; Matthew Walker; Abudu Momodu; James Fenton; Adam King; Omer Muhammed; Nicholas Oates; Tim Peakman; Christine Ryan; Kristian Spreckley; Craig Stubbins; Joanna Williams; James Brennan; Cedric Mochon; Samantha Taylor; Kimberley Warren; Stephen Kaptoge; Simon G Thompson; Emanuele Di Angelantonio; Carmel Moore; Jonathan Mant; Willem H Ouwehand; Simon G Thompson; John Danesh; David J Roberts
      Abstract: Publication date: Available online 21 September 2017
      Source:The Lancet
      Author(s): Emanuele Di Angelantonio, Simon G Thompson, Stephen Kaptoge, Carmel Moore, Matthew Walker, Jane Armitage, Willem H Ouwehand, David J Roberts, John Danesh
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared standard practice in the UK with shorter inter-donation intervals used in other countries. Methods In this parallel group, pragmatic, randomised trial, we recruited whole blood donors aged 18 years or older from 25 centres across England, UK. By use of a computer-based algorithm, men were randomly assigned (1:1:1) to 12-week (standard) versus 10-week versus 8-week inter-donation intervals, and women were randomly assigned (1:1:1) to 16-week (standard) versus 14-week versus 12-week intervals. Participants were not masked to their allocated intervention group. The primary outcome was the number of donations over 2 years. Secondary outcomes related to safety were quality of life, symptoms potentially related to donation, physical activity, cognitive function, haemoglobin and ferritin concentrations, and deferrals because of low haemoglobin. This trial is registered with ISRCTN, number ISRCTN24760606, and is ongoing but no longer recruiting participants. Findings 45 263 whole blood donors (22 466 men, 22 797 women) were recruited between June 11, 2012, and June 15, 2014. Data were analysed for 45 042 (99·5%) participants. Men were randomly assigned to the 12-week (n=7452) versus 10-week (n=7449) versus 8-week (n=7456) groups; and women to the 16-week (n=7550) versus 14-week (n=7567) versus 12-week (n=7568) groups. In men, compared with the 12-week group, the mean amount of blood collected per donor over 2 years increased by 1·69 units (95% CI 1·59–1·80; approximately 795 mL) in the 8-week group and by 0·79 units (0·69–0·88; approximately 370 mL) in the 10-week group (p<0·0001 for both). In women, compared with the 16-week group, it increased by 0·84 units (95% CI 0·76–0·91; approximately 395 mL) in the 12-week group and by 0·46 units (0·39–0·53; approximately 215 mL) in the 14-week group (p<0·0001 for both). No significant differences were observed in quality of life, physical activity, or cognitive function across randomised groups. However, more frequent donation resulted in more donation-related symptoms (eg, tiredness, breathlessness, feeling faint, dizziness, and restless legs, especially among men [for all listed symptoms]), lower mean haemoglobin and ferritin concentrations, and more deferrals for low haemoglobin (p<0·0001 for each) than those observed in the standard frequency groups. Interpretation Over 2 years, more frequent donation than is standard practice in the UK collected substantially more blood without having a major effect on donors' quality of life, physical activity, or cognitive function, but resulted in more donation-related symptoms, deferrals, and iron deficiency. Funding NHS Blood and Transplant, National Institute for Health Research, UK Medical Research Council, and British Heart Foundation.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31928-1
       
  • The price of blood is measured in iron
    • Authors: Alan E Mast; Edward L Murphy
      Abstract: Publication date: Available online 21 September 2017
      Source:The Lancet
      Author(s): Alan E Mast, Edward L Murphy


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32156-6
       
  • Ethnic cleansing in Myanmar: the Rohingya crisis and human rights
    • Authors: Chris Beyrer; Adeeba Kamarulzaman
      Abstract: Publication date: Available online 21 September 2017
      Source:The Lancet
      Author(s): Chris Beyrer, Adeeba Kamarulzaman


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32519-9
       
  • The effect of physical activity on mortality and cardiovascular disease in
           130 000 people from 17 high-income, middle-income, and low-income
           countries: the PURE study
    • Authors: Scott A Lear; Weihong Hu; Sumathy Rangarajan; Danijela Gasevic; Darryl Leong; Romaina Iqbal; Amparo Casanova; Sumathi Swaminathan; R M Anjana; Rajesh Kumar; Annika Rosengren; Li Wei; Wang Yang; Wang Chuangshi; Liu Huaxing; Sanjeev Nair; Rafael Diaz; Hany Swidon; Rajeev Gupta; Noushin Mohammadifard; Patricio Lopez-Jaramillo; Aytekin Oguz; Katarzyna Zatonska; Pamela Seron; Alvaro Avezum; Paul Poirier; Koon Teo; Salim Yusuf
      Abstract: Publication date: Available online 21 September 2017
      Source:The Lancet
      Author(s): Scott A Lear, Weihong Hu, Sumathy Rangarajan, Danijela Gasevic, Darryl Leong, Romaina Iqbal, Amparo Casanova, Sumathi Swaminathan, R M Anjana, Rajesh Kumar, Annika Rosengren, Li Wei, Wang Yang, Wang Chuangshi, Liu Huaxing, Sanjeev Nair, Rafael Diaz, Hany Swidon, Rajeev Gupta, Noushin Mohammadifard, Patricio Lopez-Jaramillo, Aytekin Oguz, Katarzyna Zatonska, Pamela Seron, Alvaro Avezum, Paul Poirier, Koon Teo, Salim Yusuf
      Background Physical activity has a protective effect against cardiovascular disease (CVD) in high-income countries, where physical activity is mainly recreational, but it is not known if this is also observed in lower-income countries, where physical activity is mainly non-recreational. We examined whether different amounts and types of physical activity are associated with lower mortality and CVD in countries at different economic levels. Methods In this prospective cohort study, we recruited participants from 17 countries (Canada, Sweden, United Arab Emirates, Argentina, Brazil, Chile, Poland, Turkey, Malaysia, South Africa, China, Colombia, Iran, Bangladesh, India, Pakistan, and Zimbabwe). Within each country, urban and rural areas in and around selected cities and towns were identified to reflect the geographical diversity. Within these communities, we invited individuals aged between 35 and 70 years who intended to live at their current address for at least another 4 years. Total physical activity was assessed using the International Physical Activity Questionnaire (IPQA). Participants with pre-existing CVD were excluded from the analyses. Mortality and CVD were recorded during a mean of 6·9 years of follow-up. Primary clinical outcomes during follow-up were mortality plus major CVD (CVD mortality, incident myocardial infarction, stroke, or heart failure), either as a composite or separately. The effects of physical activity on mortality and CVD were adjusted for sociodemographic factors and other risk factors taking into account household, community, and country clustering. Findings Between Jan 1, 2003, and Dec 31, 2010, 168 916 participants were enrolled, of whom 141 945 completed the IPAQ. Analyses were limited to the 130 843 participants without pre-existing CVD. Compared with low physical activity (<600 metabolic equivalents [MET] × minutes per week or <150 minutes per week of moderate intensity physical activity), moderate (600–3000 MET × minutes or 150–750 minutes per week) and high physical activity (>3000 MET × minutes or >750 minutes per week) were associated with graded reduction in mortality (hazard ratio 0·80, 95% CI 0·74–0·87 and 0·65, 0·60–0·71; p<0·0001 for trend), and major CVD (0·86, 0·78–0·93; p<0·001 for trend). Higher physical activity was associated with lower risk of CVD and mortality in high-income, middle-income, and low-income countries. The adjusted population attributable fraction for not meeting the physical activity guidelines was 8·0% for mortality and 4·6% for major CVD, and for not meeting high physical activity was 13·0% for mortality and 9·5% for major CVD. Both recreational and non-recreational physical activity were associated with benefits. Interpretation Higher recreational and non-recreational physical activity was associated with a lower risk of mortality and CVD events in individuals from low-income, middle-income, and high-income countries. Increasing physical activity is a simple, widely applicable, low cost global strategy that could reduce deaths and CVD in middle age. Funding Population Health Research Institute, the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario, Ontario SPOR Support Unit, Ontario Ministry of Health and Long-Term Care, AstraZeneca, Sanofi-Aventis, Boehringer Ingelheim, Servier, GSK, Novartis, King Pharma, and national and local organisations in participating countries that are listed at the end of the Article.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31634-3
       
  • Physical activity lowers mortality and heart disease risks
    • Authors: Shifalika Goenka; I-Min Lee
      Abstract: Publication date: Available online 21 September 2017
      Source:The Lancet
      Author(s): Shifalika Goenka, I-Min Lee


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32104-9
       
  • Health professional education on trafficking: the facts matter
    • Authors: Hanni Stoklosa; Susie B Baldwin
      Abstract: Publication date: Available online 19 September 2017
      Source:The Lancet
      Author(s): Hanni Stoklosa, Susie B Baldwin


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32453-4
       
  • Child mortality: the challenge for India and the world
    • Authors: Shams El Arifeen; Honorati Masanja; Ahmed Ehsanur Rahman
      Abstract: Publication date: Available online 19 September 2017
      Source:The Lancet
      Author(s): Shams El Arifeen, Honorati Masanja, Ahmed Ehsanur Rahman


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32469-8
       
  • Changes in cause-specific neonatal and 1–59-month child mortality in
           India from 2000 to 2015: a nationally representative survey
    • Authors: Shaza A Fadel; Reeta Rasaily; Shally Awasthi; Rehana Begum; Robert E Black; Hellen Gelband; Patrick Gerland; Rajesh Kumar; Li Liu; Colin Mathers; Shaun K Morris; Saritha Nair; Leslie Newcombe; Arvind Pandey; Faujdar Ram; Usha Ram; Peter S Rodriguez; Damodar Sahu; Prabha Sati; Prakash J Shah; Anita Shet; Jay Sheth; Jitenkumar K Singh; Lucky Singh; Anju Sinha; Wilson Suraweera; Prabhat Jha
      Abstract: Publication date: Available online 19 September 2017
      Source:The Lancet
      Author(s): Million Death Study CollaboratorsShaza AFadelReetaRasailyShallyAwasthiRehanaBegumRobert EBlackHellenGelbandPatrickGerlandRajeshKumarLiLiuColinMathersShaun KMorrisSarithaNairLeslieNewcombeArvindPandeyFaujdarRamUshaRamPeter SRodriguezDamodarSahuPrabhaSatiPrakash JShahAnitaShetJayShethJitenkumar KSinghLuckySinghAnjuSinhaWilsonSuraweeraPrabhatJha
      Background Documentation of the demographic and geographical details of changes in cause-specific neonatal (younger than 1 month) and 1–59-month mortality in India can guide further progress in reduction of child mortality. In this study we report the changes in cause-specific child mortality between 2000 and 2015 in India. Methods Since 2001, the Registrar General of India has implemented the Million Death Study (MDS) in 1·3 million homes in more than 7000 randomly selected areas of India. About 900 non-medical surveyors do structured verbal autopsies for deaths recorded in these homes. Each field report is assigned randomly to two of 404 trained physicians to classify the cause of death, with a standard process for resolution of disagreements. We combined the proportions of child deaths according to the MDS for 2001–13 with annual UN estimates of national births and deaths (partitioned across India's states and rural or urban areas) for 2000–15. We calculated the annual percentage change in sex-specific and cause-specific mortality between 2000 and 2015 for neonates and 1–59-month-old children. Findings The MDS captured 52 252 deaths in neonates and 42 057 deaths at 1–59 months. Examining specific causes, the neonatal mortality rate from infection fell by 66% from 11·9 per 1000 livebirths in 2000 to 4·0 per 1000 livebirths in 2015 and the rate from birth asphyxia or trauma fell by 76% from 9·0 per 1000 livebirths in 2000 to 2·2 per 1000 livebirths in 2015. At 1–59 months, the mortality rate from pneumonia fell by 63% from 11·2 per 1000 livebirths in 2000 to 4·2 per 1000 livebirths in 2015 and the rate from diarrhoea fell by 66% from 9·4 per 1000 livebirths in 2000 to 3·2 per 1000 livebirths in 2015 (with narrowing girl–boy gaps). The neonatal tetanus mortality rate fell from 1·6 per 1000 livebirths in 2000 to less than 0·1 per 1000 livebirths in 2015 and the 1–59-month measles mortality rate fell from 3·3 per 1000 livebirths in 2000 to 0·3 per 1000 livebirths in 2015. By contrast, mortality rates for prematurity or low birthweight rose from 12·3 per 1000 livebirths in 2000 to 14·3 per 1000 livebirths in 2015, driven mostly by increases in term births with low birthweight in poorer states and rural areas. 29 million cumulative child deaths occurred from 2000 to 2015. The average annual decline in mortality rates from 2000 to 2015 was 3·3% for neonates and 5·4% for children aged 1–59 months. Annual declines from 2005 to 2015 (3·4% decline for neonatal mortality and 5·9% decline in 1–59-month mortality) were faster than were annual declines from 2000 to 2005 (3·2% decline for neonatal mortality and 4·5% decline in 1–59-month mortality). These faster declines indicate that India avoided about 1 million child deaths compared with continuation of the 2000–05 declines. Interpretation To meet the 2030 Sustainable Development Goals for child mortality, India will need to maintain the current trajectory of 1–59-month mortality and accelerate declines in neonatal mortality (to >5% annually) from 2015 onwards. Continued progress in reduction of child mortality due to pneumonia, diarrhoea, malaria, and measles at 1–59 months is feasible. Additional attention to low birthweight is required. Funding National Institutes of Health, Disease Control Priorities Network, Maternal and Child Epidemiology Estimation Group, and University of Toronto.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32162-1
       
  • Department of Error
    • Abstract: Publication date: Available online 18 September 2017
      Source:The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • The NCDs Cooperative: a call to action
    • Authors: Sania Nishtar
      Abstract: Publication date: Available online 18 September 2017
      Source:The Lancet
      Author(s): Sania Nishtar


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32481-9
       
  • Department of Error
    • Abstract: Publication date: Available online 18 September 2017
      Source:The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • Hyperparathyroidism
    • Authors: John P Bilezikian; Leonardo Bandeira; Aliya Khan; Natalie E Cusano
      Abstract: Publication date: Available online 17 September 2017
      Source:The Lancet
      Author(s): John P Bilezikian, Leonardo Bandeira, Aliya Khan, Natalie E Cusano
      Primary hyperparathyroidism is a common endocrine disorder of calcium metabolism characterised by hypercalcaemia and elevated or inappropriately normal concentrations of parathyroid hormone. Almost always, primary hyperparathyroidism is due to a benign overgrowth of parathyroid tissue either as a single gland (80% of cases) or as a multiple gland disorder (15–20% of cases). Primary hyperparathyroidism is generally discovered when asymptomatic but the disease always has the potential to become symptomatic, resulting in bone loss and kidney stones. In countries where biochemical screening tests are not common, symptomatic primary hyperparathyroidism tends to predominate. Another variant of primary hyperparathyroidism has been described in which the serum calcium concentration is within normal range but parathyroid hormone is elevated in the absence of any obvious cause. Primary hyperparathyroidism can be cured by removal of the parathyroid gland or glands but identification of patients who are best advised to have surgery requires consideration of the guidelines that are regularly updated. Recommendations for patients who do not undergo parathyroid surgery include monitoring of serum calcium concentrations and bone density.

      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)31430-7
       
  • California Universal Health Care Bill: an economic stimulus and
           life-saving proposal
    • Authors: Alison P Galvani; David P Durham; Sten H Vermund; Meagan C Fitzpatrick
      Abstract: Publication date: Available online 17 September 2017
      Source:The Lancet
      Author(s): Alison P Galvani, David P Durham, Sten H Vermund, Meagan C Fitzpatrick


      PubDate: 2017-09-23T11:20:59Z
      DOI: 10.1016/s0140-6736(17)32148-7
       
  • Department of Error
    • Abstract: Publication date: Available online 17 September 2017
      Source:The Lancet


      PubDate: 2017-09-23T11:20:59Z
       
  • Global, regional, and national under-5 mortality, adult mortality,
           age-specific mortality, and life expectancy, 1970–2016: a systematic
           analysis for the Global Burden of Disease Study 2016
    • Authors: GBD 2016; Mortality CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahSemaw FeredeAberaHaftom NiguseAbrahaLaith JAbu-RaddadNiveen
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 Mortality CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahSemaw FeredeAberaHaftom NiguseAbrahaLaith JAbu-RaddadNiveen M EAbu-RmeilehIsaac AkinkunmiAdedejiRufus AdesojiAdedoyinIfedayo Morayo OAdetifaOlatunjiAdetokunbohAshkanAfshinRakeshAggarwalAnuragAgrawalSutapaAgrawalAliasgharAhmad KiadaliriMuktar BeshirAhmedMiloud Taki EddineAichourAmani NidhalAichourIbthielAichourSnehaAiyarAli ShafqatAkandaTomi FAkinyemijuNadiaAkseerFaris HasanAl LamiSamerAlabedFaresAlahdabZiyadAl-AlyKhurshidAlamNooreAlamDeenaAlasfoorRobert WilliamAldridgeKefyalew AddisAleneAymanAl-EyadhySamiaAlhabibRaghibAliRezaAlizadeh-NavaeiSyed MAljunidJuma MAlkaabiAla'aAlkerwiFrançoisAllaShalini DAllamPeterAllebeckRajaaAl-RaddadiUbaiAlsharifKhalid AAltirkawiNelsonAlvis-GuzmanAzmeraw TAmareEmmanuel AAmehErfanAminiWalidAmmarYaw AmpemAmoakoNahlaAnberCatalina LilianaAndreiSofiaAndroudiHosseinAnsariMustafa GeletoAnshaCarl Abelardo TAntonioPalwashaAnwariJohanÄrnlövMeghaAroraAlArtamanKrishna KumarAryalHamidAsayeshSolomon WeldegebrealAsgedomRana JawadAsgharRezaAssadiAshagre MollaAssayeTesfay MehariAteySachin RAtreLeticiaAvila-BurgosEuripide Frinel G ArthurAvokpahoAshishAwasthiTesleem KayodeBabalolaUmarBachaAlaaBadawiKalpanaBalakrishnanShivanthiBalallaAleksandraBaracRyan MBarberMiguel ABarbozaSuzanne LBarker-ColloTillBärnighausenSimonBarqueraLarsBarregardLope HBarreroBernhard TBauneShahrzadBazargan-HejaziNeerajBediEttoreBeghiYannickBéjotBayu BegashawBekeleMichelle LBellAminu KBelloDerrick ABennettJames RBennettIsabela MBensenorJenniferBensonAdugnawBerhaneDerbew FikaduBerheEduardoBernabéMirceaBeuranAddisu ShunuBeyeneNeerajBhalaAnilBhansaliSoumyadeepBhaumikZulfiqar ABhuttaBurcu KucukBicerHassan HaghparastBidgoliBorisBikbovCharlesBirungiStanBiryukovDonalBisanzioHabtamu MellieBizuayehuPeterBjerregaardChristopher DBlosserDube JaraBoneyaSoufianeBoufousRupert R ABourneAlexandraBrazinovaNicholas J KBreitbordeHermannBrennerTraolach SBrughaGeneBukhmanLemma Negesa BultoBultoBlair RandalBumgarnerMichaelBurchZahid AButtLeah ECahillLuceroCahuana-HurtadoIsmael RicardoCampos-NonatoJosipCarMateCarRosarioCárdenasDavid OCarpenterJuan JesusCarreroAustinCarterCarlos ACastañeda-OrjuelaFranz FCastroRuben EstanislaoCastroFerránCatalá-LópezHongleiChenPeggy Pei-ChiaChiangMirriamChibalabalaVesper HichilombweChisumpaAbdulaal AChitheerJee-Young JasmineChoiHanneChristensenDevasahayam JesudasChristopherLiliana GCiobanuMassimoCirilloAaron JCohenSamantha MColquhounJosefCoreshMichael HCriquiElizabeth ACromwellJohn ACrumpLalitDandonaRakhiDandonaPaul IDarganJosédas NevesGailDaveyDragos VDavitoiuKairatDavletovBarborade CourtenDiegoDe LeoLouisaDegenhardtSelinaDeiparineRobert PDellavalleKebedeDeribeAmareDeribewDon CDes JarlaisSubhojitDeySamath DDharmaratneMukesh KDheraniCesarDiaz-TornéEric LDingPriyankaDixitShirinDjalaliniaHuyen PhucDoDavid TeyeDokuChristl AnnDonnellyKadine Priscila Benderdos SantosDirkDouwes-SchultzTim RDriscollLeileiDuanManishaDubeyBruce BartholowDuncanLaxmi KantDwivediHedyehEbrahimiCharbelEl BcheraouiChristian LyckeEllingsenAhmadaliEnayatiAman YesufEndriesSergey PetrovichErmakovSetegnEshetieBabakEshratiShararehEskandariehAlirezaEsteghamatiKaraEstepFanuel Belayneh BekeleFanuelAndréFaroMaryam SFarvidFarshadFarzadfarValery LFeiginSeyed-MohammadFereshtehnejadJefferson GFernandesJoão CFernandesTesfaye RegassaFeyissaIrinaFilipFlorianFischerNataliyaFoigtKyle JForemanTahviFrankRichard CFranklinMayaFraserJosephFriedmanJoseph JFrostadNancyFullmanThomasFürstJoao MFurtadoNeal DFutranEmmanuelaGakidouKetevanGambashidzeAmiranGamkrelidzeFortuné GbètohoGankpéAlberto LGarcia-BasteiroGebremedhin BerheGebregergsTsegaye TeweldeGebrehiwotKahsu GebrekirstosGebrekidanMengistu WeldayGebremichaelAmha AdmasieGelayeJohanna MGeleijnseBikila LenchaGemechuKasiye ShiferawGemechuRicardGenova-MalerasHailay AbrhaGesesewPeter WGethingKatherine BGibneyParamjit SinghGillRichard FGillumAbabi ZergawGirefBedilu WejiGirmaGiorgiaGiussaniShifalikaGoenkaBeatrizGomezPhilimon NGonaSameer ValiGopalaniAlessandra CarvalhoGoulartNicholasGraetzHarish ChanderGugnaniPrakash CGuptaRahulGuptaRajeevGuptaTanushGuptaVipinGuptaJuanita AHaagsmaNimaHafezi-NejadAlexHakuzimanaYara AHalasaRandah RibhiHamadehMitiku TeshomeHambisaSamerHamidiMouhanadHammamiJamieHancockAlexis JHandalGraeme JHankeyYuantaoHaoHilda LHarbHabtamu AberaHareriSivadasanpillaiHarikrishnanJosep MariaHaroMohammad SadeghHassanvandRasmusHavmoellerRoderick JHaySimon IHayFeiHeIleana BeatrizHeredia-PiClaudiuHerteliuEsayas HaregotHilaweHans WHoekNobuyukiHoritaH DeanHosgoodSorinHostiucPeter JHotezDamian GHoyMohamedHsairiAung SoeHtetGuoqingHuJohn JHuangHsiangHuangKim MoesgaardIburgEhimario UcheIgumborBogdan VasileIleanuManamiInoueAsnake ArarsaIrensoCaleb M SIrvineSheikh Mohammed SharifulIslamNazrulIslamKathryn HJacobsenThomasJaenischNaderJahanmehrMihajlo BJakovljevicMehdiJavanbakhtAchala UpendraJayatillekePanniyammakalJeemonPaul NJensenVivekanandJhaYeJinDennyJohnOommenJohnSarah CharlotteJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayYogeshwarKalkondeRitulKamalHaidongKanAndréKarchCorine KakiziKaremaSeyed MKarimiGanesanKarthikeyanAmirKasaeianNigussie AssefaKassawNicholas JKassebaumAnshulKastorSrinivasa VittalKatikireddiAnilKaulNoritoKawakamiKonstantinKazanjanPeter NjengaKeiyoroSefonias GetachewKelboreAndrew HaddonKempAndre PascalKengneAndreKerenMaiaKereselidzeChandrasekharan NairKesavachandranEzra BelayKetemaYousef SalehKhaderIbrahim AKhalilEjaz AhmadKhanGulfarazKhanYoung-HoKhangSahilKheraAbdullah Tawfih AbdullahKhojaMohammad HosseinKhosraviGetiye DejenuKibretChristianKielingYun JinKimCho-ilKimDanielKimPaulineKimSungroulKimRuth WKimokotiYohannesKinfuSamiKishawiNiranjanKissoonMikaKivimakiAnn KristinKnudsenYoshihiroKokuboJacek AKopecSoewartaKosenP...
      PubDate: 2017-09-23T11:20:59Z
       
  • Global, regional, and national age-sex specific mortality for 264 causes
           of death, 1980–2016: a systematic analysis for the Global Burden of
           Disease Study 2016
    • Authors: GBD 2016; Causes Death CollaboratorsAmanuel AlemuAbajobirCristianaAbbafatiKaja MAbbasFoadAbd-AllahSemaw FeredeAberaVictorAboyansOlatunjiAdetokunbohAshkanAfshinAnuragAgrawalAlirezaAhmadiMuktar BeshirAhmedAmani NidhalAichourMiloud
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 Causes of Death CollaboratorsAmanuel AlemuAbajobirCristianaAbbafatiKaja MAbbasFoadAbd-AllahSemaw FeredeAberaVictorAboyansOlatunjiAdetokunbohAshkanAfshinAnuragAgrawalAlirezaAhmadiMuktar BeshirAhmedAmani NidhalAichourMiloud Taki EddineAichourIbtihelAichourSnehaAiyarFaresAlahdabZiyadAl-AlyKhurshidAlamNooreAlamTahiyaAlamKefyalew AddisAleneAymanAl-EyadhySyed DanishAliRezaAlizadeh-NavaeiJuma MAlkaabiAla'aAlkerwiFrançoisAllaPeterAllebeckChristineAllenRajaaAl-RaddadiUbaiAlsharifKhalid AAltirkawiNelsonAlvis-GuzmanAzmeraw TAmareErfanAminiWalidAmmarYaw AmpemAmoakoNahlaAnberHjalte HAndersenCatalina LilianaAndreiSofiaAndroudiHosseinAnsariCarl Abelardo TAntonioPalwashaAnwariJohanÄrnlövMeghaAroraAlArtamanKrishna KumarAryalHamidAsayeshSolomon WAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripide Frinel GAvokpahoAshishAwasthiTesleem KayodeBabalolaUmarBachaKalpanaBalakrishnanAleksandraBaracMiguel ABarbozaSuzanne LBarker-ColloSimonBarqueraLarsBarregardLope HBarreroBernhard TBauneNeerajBediEttoreBeghiYannickBéjotBayu BegashawBekeleMichelle LBellJames RBennettIsabela MBensenorAdugnawBerhaneEduardoBernabéBalem DemtsuBetsuMirceaBeuranSamirBhattSibhatuBiadgilignKellyBienhoffBorisBikbovDonalBisanzioRupert R ABourneNicholas J KBreitbordeLemma Negesa BultoBultoBlair RBumgarnerZahid AButtLuceroCahuana-HurtadoEwanCameronJulio CesarCampuzanoJosipCarRosarioCárdenasJuan JesusCarreroAustinCarterDaniel CCaseyCarlos ACastañeda-OrjuelaFerránCatalá-LópezFiona JCharlsonChioma EzinneChibuezeOdgerelChimed-OchirVesper HichilombweChisumpaAbdulaal AChitheerDevasahayam JesudasChristopherLiliana GCiobanuMassimoCirilloAaron JCohenDannyColombaraCyrusCooperBenjamin CCowieMichael HCriquiLalitDandonaRakhiDandonaPaul IDarganJosédas NevesDragos VDavitoiuKairatDavletovBarborade CourtenBarthelemy KuateDefoLouisaDegenhardtSelinaDeiparineKebedeDeribeAmareDeribewSubhojitDeyDanielDickerEric LDingShirinDjalaliniaHuyen PhucDoDavid TeyeDokuDirkDouwes-SchultzTim RDriscollManishaDubeyBruce BartholowDuncanMichelleEchkoZiad ZiadEl-KhatibChristian LyckeEllingsenAhmadaliEnayatiHolly EErskineShararehEskandariehAlirezaEsteghamatiKaraEstepCarla Sofia e SaFarinhaAndréFaroFarshadFarzadfarValery LFeiginSeyed-MohammadFereshtehnejadJoão CFernandesAlize JFerrariTesfaye RegassaFeyissaIrinaFilipSamuelFinegoldFlorianFischerChristinaFitzmauriceAbraham DFlaxmanNataliyaFoigtTahviFrankMayaFraserNancyFullmanThomasFürstJoao MFurtadoEmmanuelaGakidouAlberto LGarcia-BasteiroTeshomeGebreGebremedhin BerheGebregergsTsegaye TeweldeGebrehiwotDelelegn YilmaGebremichaelJohanna MGeleijnseRicardGenova-MalerasHailay AbrhaGesesewPeter WGethingRichard FGillumMauriceGiroudGiorgiaGiussaniWilliam WGodwinAudra LGoldEllen MGoldbergPhilimon NGonaSameer ValiGopalaniHebe NGoudaAlessandra CarvalhoGoulartMaxGriswoldRajeevGuptaTanushGuptaVipinGuptaJuanita AHaagsmaNimaHafezi-NejadAlemayehu DesalegneHailuGessessew BugssaHailuRandah RibhiHamadehMitiku TeshomeHambisaSamerHamidiMouhanadHammamiJamieHancockAlexis JHandalGraeme JHankeyYuantaoHaoHilda LHarbHabtamu AberaHareriMohammad SadeghHassanvandRasmusHavmoellerSimon IHayFeiHeMohammad THedayatiNathaniel JHenryIleana BeatrizHeredia-PiClaudiuHerteliuHans WHoekMasakoHorinoNobuyukiHoritaH DeanHosgoodSorinHostiucPeter JHotezDamian GHoyChantalHuynhKim MoesgaardIburgChadIkedaBogdan VasileIleanuAsnake ArarsaIrensoCaleb Mackay SalpeterIrvineSheikh Mohammed SharifulIslamKathryn HJacobsenNaderJahanmehrMihajlo BJakovljevicMehdiJavanbakhtSudha PJayaramanPanniyammakalJeemonVivekanandJhaDennyJohnCatherine OJohnsonSarah CharlotteJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayRitulKamalAndréKarchSeyed MKarimiChanteKarimkhaniAmirKasaeianNigussie AssefaKassawNicholas JKassebaumSrinivasa VittalKatikireddiNoritoKawakamiPeter NjengaKeiyoroLauraKemmerChandrasekharan NairKesavachandranYousef SalehKhaderEjaz AhmadKhanYoung-HoKhangAbdullah Tawfih AbdullahKhojaMohammad HosseinKhosraviArdeshirKhosraviJagdishKhubchandaniAliasghar AhmadKiadaliriChristianKielingDanielKievlanYun JinKimDanielKimRuth WKimokotiYohannesKinfuNiranjanKissoonMikaKivimakiAnn KristinKnudsenJacek AKopecSoewartaKosenParvaiz AKoulAiKoyanagiXie RachelKulikoffG AnilKumarPushpendraKumarMichaelKutzHmwe HKyuDharmesh KumarLalRatilalLallooTea Lallukka NkurunzizaLambertQingLanVan CLansinghAndersLarssonPaul HLeeJamesLeighJanniLeungMiriamLeviYongmeiLiDaryaLi KappeXiaofengLiangMisgan LegesseLibenStephen SLimPatrick YLiuAngelaLiuYangLiuRakeshLodhaGiancarloLogroscinoAlan DLopezStefanLorkowskiPaulo ALotufoRafaelLozanoTimothy C DLucasStefanMaErlyn Rachelle KingMacarayanEmilie RMaddisonMohammedMagdy Abd El RazekMarekMajdanRezaMajdzadehAzeemMajeedRezaMalekzadehRajeshMalhotraDeborah CarvalhoMaltaHelenaManguerraTsegahunManyazewalChabila CMapomaLaurie BMarczakDesalegnMarkosJoseMartinez-RagaFrancisco RogerlândioMartins-MeloIraMartopulloColmMcAlindenMadelineMcGaugheyJohn JMcGrathSureshMehataToniMeierKidanu GebremariamMelesPeterMemiahZiad AMemishMelkamu MeridMengeshaDesalegn TadeseMengistuBereket GebremichaelMenotaGeorge AMensahTuomo JMeretojaAtteMeretojaAnoushkaMillearTed RMillerShawnMinnigMojdeMirarefinErkin MMirrakhimovAwokeMisganawShiva RajMishraIbrahim AbdelmageemMohamedKarzan AbdulmuhsinMohammadAlirezaMohammadiShafiuMohammedAli HMokdadGlen Liddell DMolaSarah KMollenkopfMariamMolokhiaLorenzoMonastaJulio CMontañezMarcellaMonticoMeghan DMooneyMaziarMoradi-LakehPaulaMoragaLidiaMorawskaChloeMorozoffShane DMorrisonCliffMountjoy-VenningKalayu BirhaneMrutsKateMullerChristopher J LMurrayGudlavalleti Venkata SatyanarayanaMurthyKamarul ImranMusaJean BNachegaMohsenNaghaviAliyaNaheedLuigiNaldiVinayNangiaBruno RamosNascimentoJamal TNasherGopalakrishnanNatarajanIonutNegoiJosephine WanjikuNgunjiriCuong TatNguyenQuyen LeNguyenTrang HuyenNguyenGrantNguyenMinhNguyenEmmaNicholsDina Nur Anggra...
      PubDate: 2017-09-23T11:20:59Z
       
  • Global, regional, and national incidence, prevalence, and years lived with
           disability for 328 diseases and injuries for 195 countries, 1990–2016: a
           systematic analysis for the Global Burden of Disease Study 2016
    • Authors: GBD 2016; Disease Injury Incidence Prevalence CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 Disease and Injury Incidence and Prevalence CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan SuliankatchiAbdulkaderAbdishakur MAbdulleTeshome AbukaAbeboSemaw FeredeAberaVictorAboyansLaith JAbu-RaddadIlana NAckermanAbdu AbdullahiAdamuOlatunjiAdetokunbohMohsenAfaridehAshkanAfshinSanjay KumarAgarwalRakeshAggarwalAnuragAgrawalSutapaAgrawalHamidAhmadiehMuktar BeshirAhmedMiloud Taki EddineAichourAmani NidhalAichourIbtihelAichourSnehaAiyarRufus OlusolaAkinyemiNadiaAkseerFaris HasanAl LamiFaresAlahdabZiyadAl-AlyKhurshidAlamNooreAlamTahiyaAlamDeenaAlasfoorKefyalew AddisAleneRaghibAliRezaAlizadeh-NavaeiAla'aAlkerwiFrançoisAllaPeterAllebeckChristineAllenFatmaAl-MaskariRajaaAl-RaddadiUbaiAlsharifShirinaAlsowaidiKhalid AAltirkawiAzmeraw TAmareErfanAminiWalidAmmarYaw AmpemAmoakoHjalte HAndersenCarl Abelardo TAntonioPalwashaAnwariJohanÄrnlövAlArtamanKrishna KumarAryalHamidAsayeshSolomon WAsgedomRezaAssadiTesfay MehariAteyNiguse TadeleAtnafuSachin RAtreLeticiaAvila-BurgosEuripide Frinel G ArthurAvokphakoAshishAwasthiUmarBachaAlaaBadawiKalpanaBalakrishnanAmitavaBanerjeeMarlena SBannickAleksandraBaracRyan MBarberSuzanne LBarker-ColloTillBärnighausenSimonBarqueraLarsBarregardLope HBarreroSanjayBasuBobBattistaKatherine EBattleBernhard TBauneShahrzadBazargan-HejaziJustinBeardsleyNeerajBediEttoreBeghiYannickBéjotBayu BegashawBekeleMichelle LBellDerrick ABennettIsabela MBensenorJenniferBensonAdugnawBerhaneDerbew FikaduBerheEduardoBernabéBalem DemtsuBetsuMirceaBeuranAddisu ShunuBeyeneNeerajBhalaAnilBhansaliSamirBhattZulfiqar ABhuttaSibhatuBiadgilignBurcu KucukBicerKellyBienhoffBorisBikbovCharlesBirungiStanBiryukovDonalBisanzioHabtamu MellieBizuayehuDube JaraBoneyaSoufianeBoufousRupert R ABourneAlexandraBrazinovaTraolach SBrughaRachelleBuchbinderLemma Negesa BultoBultoBlair RBumgarnerZahid AButtLuceroCahuana-HurtadoEwanCameronMateCarHélèneCarabinJonathan RCarapetisRosarioCárdenasDavid OCarpenterJuan JesusCarreroAustinCarterFelixCarvalhoDaniel CCaseyValeriaCasoCarlos ACastañeda-OrjuelaChris DCastleFerránCatalá-LópezHsing-YiChangJung-ChenChangFiona JCharlsonHongleiChenMirriamChibalabalaChioma EzinneChibuezeVesper HichilombweChisumpaAbdulaal AChitheerDevasahayam JesudasChristopherLiliana GCiobanuMassimoCirilloDannyColombaraCyrusCooperPaolo AngeloCortesiMichael HCriquiJohn ACrumpAbel FekaduDadiKoustuvDalalLalitDandonaRakhiDandonaJosédas NevesDragos VDavitoiuBarborade CourtenDiego DeDe LeoBarthelemy KuateDefoLouisaDegenhardtSelinaDeiparineRobert PDellavalleKebedeDeribeDon CDes JarlaisSubhojitDeySamath DDharmaratnePreet KaurDhillonDanielDickerEric LDingShirinDjalaliniaHuyen PhucDoE RayDorseyKadine Priscila Benderdos SantosDirkDouwes-SchultzKerrie EDoyleTim RDriscollManishaDubeyBruce BartholowDuncanZiad ZiadEl-KhatibJerishaEllerstrandAhmadaliEnayatiAman YesufEndriesSergey PetrovichErmakovHolly EErskineBabakEshratiShararehEskandariehAlirezaEsteghamatiKaraEstepFanuel Belayneh BekeleFanuelCarla Sofia E SaFarinhaAndréFaroFarshadFarzadfarMir SohailFazeliValery LFeiginSeyed-MohammadFereshtehnejadJoão CFernandesAlize JFerrariTesfaye RegassaFeyissaIrinaFilipFlorianFischerChristinaFitzmauriceAbraham DFlaxmanLuisa SorioFlorNataliyaFoigtKyle JForemanRichard CFranklinNancyFullmanThomasFürstJoao MFurtadoNeal DFutranEmmanuelaGakidouMorsalehGanjiAlberto LGarcia-BasteiroTeshomeGebreTsegaye TeweldeGebrehiwotAyeleGeletoBikila LenchaGemechuHailay AbrhaGesesewPeter WGethingAlirezaGhajarKatherine BGibneyParamjit SinghGillRichard FGillumIbrahim Abdelmageem MohamedGinawiAbabi ZergawGirefMelkamu DedefoGishuGiorgiaGiussaniWilliam WGodwinAudra LGoldEllen MGoldbergPhilimon NGonaAmadorGoodridgeSameer ValiGopalaniAtsushiGotoAlessandra CarvalhoGoulartMaxGriswoldHarish ChanderGugnaniRahulGuptaRajeevGuptaTanushGuptaVipinGuptaNimaHafezi-NejadGessessew BugssaHailuAlemayehu DesalegneHailuRandah RibhiHamadehSamerHamidiAlexis JHandalGraeme JHankeySarah WulfHansonYuantaoHaoHilda LHarbHabtamu AberaHareriJosep MariaHaroJamesHarveyMohammad SadeghHassanvandRasmusHavmoellerCaitlinHawleySimon IHayRoderick JHayNathaniel JHenryIleana BeatrizHeredia-PiJulio MontañezHernandezPouriaHeydarpourHans WHoekHoward JHoffmanNobuyukiHoritaH DeanHosgoodSorinHostiucPeter JHotezDamian GHoyAung SoeHtetGuoqingHuHsiangHuangChantalHuynhKim MoesgaardIburgEhimario UcheIgumborChadIkedaCaleb Mackay SalpeterIrvineKathryn HJacobsenNaderJahanmehrMihajlo BJakovljevicSimerjot KJassalMehdiJavanbakhtSudha PJayaramanPanniyammakalJeemonPaul NJensenVivekanandJhaGuohongJiangDennyJohnSarah CharlotteJohnsonCatherine OJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayRitulKamalHaidongKanNadim EKaramAndréKarchCorine KakiziKaremaAmirKasaeianGetachew MulluKassaNigussie AssefaKassawNicholas JKassebaumAnshulKastorSrinivasa VittalKatikireddiAnilKaulNoritoKawakamiPeter NjengaKeiyoroAndre PascalKengneAndreKerenYousef SalehKhaderIbrahim AKhalilEjaz AhmadKhanYoung-HoKhangArdeshirKhosraviJagdishKhubchandaniAliasghar AhmadKiadaliriChristianKielingYun JinKimDanielKimPaulineKimRuth WKimokotiYohannesKinfuAdnanKisaKatarzyna AKissimova-SkarbekMikaKivimakiAnn KristinKnudsenYoshihiroKokuboDhavalKolteJacek AKopecSoewartaKosenParvaiz AKoulAiKoyanagiMichaelKravchenkoSanjayKrishnaswamiKristopher JKrohnG AnilKumarPushpendraKumarSanjivKumarHmwe HKyuDharmesh KumarLalRatilalLallooNkurunzizaLambertQingLanAndersLarssonPablo MLavadosJanet LLeasherPaul HLeeJong-TaeLeeJamesLeighCheru TesemaLeshargieJanniLeungRickyLeungMiriamLeviYichongLiYongmeiLiDaryaLi KappeXiaofengLiangMisgan LegesseLibenStephen SLimShaiLinnPatrick YLiuAngelaLiuShiweiLiuYangLiuRakeshLodhaGiancarloLogroscinoStephanie JLondonKatharine JLookerAlan DLopezStefanLorkowskiPaulo ALotufoNicolaLowRafaelLozanoTimothy C DLucasErlyn Rachelle KingMacarayanHassan...
      PubDate: 2017-09-23T11:20:59Z
       
  • Global, regional, and national disability-adjusted life-years (DALYs) for
           333 diseases and injuries and healthy life expectancy (HALE) for 195
           countries and territories, 1990–2016: a systematic analysis for the
           Global Burden of Disease Study 2016
    • Authors: GBD 2016; DALYs HALE CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan SuliankatchiAbdulkaderAbdishakur MAbdulleTeshome
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 DALYs and HALE CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan SuliankatchiAbdulkaderAbdishakur MAbdulleTeshome AbukaAbeboSemaw FeredeAberaVictorAboyansLaith JAbu-RaddadIlana NAckermanIsaac AAdedejiOlatunjiAdetokunbohAshkanAfshinRakeshAggarwalSutapaAgrawalAnuragAgrawalMuktar BeshirAhmedMiloud Taki EddineAichourAmani NidhalAichourIbtihelAichourSnehaAiyarTomi FAkinyemijuNadiaAkseerFaris HasanAl LamiFaresAlahdabZiyadAl-AlyKhurshidAlamNooreAlamTahiyaAlamDeenaAlasfoorKefyalew AddisAleneRaghibAliRezaAlizadeh-NavaeiJuma MAlkaabiAla'aAlkerwiFrançoisAllaPeterAllebeckChristineAllenFatmaAl-MaskariMohammad AbdulAzizAlMazroaRajaaAl-RaddadiUbaiAlsharifShirinaAlsowaidiBenjamin MAlthouseKhalid AAltirkawiNelsonAlvis-GuzmanAzmeraw TAmareErfanAminiWalidAmmarYaw AmpemAmoakoMustafa GeletoAnshaCarl Abelardo TAntonioPalwashaAnwariJohanÄrnlövMeghaAroraAlArtamanKrishna KumarAryalSolomon WAsgedomTesfay MehariAteyNiguse TadeleAtnafuLeticiaAvila-BurgosEuripide Frinel G ArthurAvokpahoAshishAwasthiShallyAwasthiMahmoud RezaAzarpazhoohPeterAzzopardiTesleem KayodeBabalolaUmarBachaAlaaBadawiKalpanaBalakrishnanMarlena SBannickAleksandraBaracSuzanne LBarker-ColloTillBärnighausenSimonBarqueraLope HBarreroSanjayBasuRobertBattistaKatherine EBattleBernhard TBauneShahrzadBazargan-HejaziJustinBeardsleyNeerajBediYannickBéjotBayu BegashawBekeleMichelle LBellDerrick ABennettJames RBennettIsabela MBensenorJenniferBensonAdugnawBerhaneDerbew FikaduBerheEduardoBernabéBalem DemtsuBetsuMirceaBeuranAddisu ShunuBeyeneAnilBhansaliSamirBhattZulfiqar ABhuttaSibhatuBiadgilignBurcu KucukBicerKellyBienhoffBorisBikbovCharlesBirungiStanBiryukovDonalBisanzioHabtamu MellieBizuayehuFiona MBlythDube JaraBoneyaDipanBoseIbrahim RBou-OrmRupert R ABourneMichaelBraininCarolBrayneAlexandraBrazinovaNicholas J KBreitbordePaul SBriantGabrielleBrittonTraolach SBrughaRachelleBuchbinderLemma Negesa BultoBultoBlair RBumgarnerZahid AButtLuceroCahuana-HurtadoEwanCameronIsmael RicardoCampos-NonatoHélèneCarabinRosarioCárdenasDavid OCarpenterJuan JesusCarreroAustinCarterFelixCarvalhoDanielCaseyCarlos ACastañeda-OrjuelaChris DCastleFerránCatalá-LópezJung-ChenChangFiona JCharlsonPankajChaturvediHongleiChenMirriamChibalabalaChioma EzinneChibuezeVesper HichilombweChisumpaAbdulaal AChitheerRajivChowdhuryDevasahayam JesudasChristopherLiliana GCiobanuMassimoCirilloDannyColombaraLeslie TrumbullCooperCyrusCooperPaolo AngeloCortesiMonicaCortinovisMichael HCriquiElizabeth ACromwellMaritaCrossJohn ACrumpAbel FekaduDadiKoustuvDalalAlbertinoDamascenoLalitDandonaRakhiDandonaJosédas NevesDragos VDavitoiuKairatDavletovBarborade CourtenDiegoDe LeoHansDe SteurBarthelemy KuateDefoLouisaDegenhardtSelinaDeiparineRobert PDellavalleKebedeDeribeAmareDeribewDon CDes JarlaisSubhojitDeySamath DDharmaratnePreet KDhillonDanielDickerShirinDjalainiaHuyen PhucDoKlaraDokovaDavid TeyeDokuE RayDorseyKadine Priscila Benderdos SantosTim RDriscollManishaDubeyBruce BartholowDuncanBeth EEbelMichelleEchkoZiad ZiadEl-KhatibAhmadaliEnayatiAman YesufEndriesSergey PetrovichErmakovHolly EErskineSetegnEshetieBabakEshratiAlirezaEsteghamatiKaraEstepFanuel Belayneh BekeleFanuelTamerFaragCarla Sofia e SaFarinhaAndréFaroFarshadFarzadfarMir SohailFazeliValery LFeiginAndrea BFeiglSeyed-MohammadFereshtehnejadJoão CFernandesAlize JFerrariTesfaye RegassaFeyissaIrinaFilipFlorianFischerChristinaFitzmauriceAbraham DFlaxmanNataliyaFoigtKyle JForemanRichard CFranklinJoseph JFrostadNancyFullmanThomasFürstJoao MFurtadoNeal DFutranEmmanuelaGakidouAlberto LGarcia-BasteiroTeshomeGebreGebremedhin BerheGebregergsTsegaye TeweldeGebrehiwotJohanna MGeleijnseAyeleGeletoBikila LenchaGemechuHailay AbrhaGesesewPeter WGethingAlirezaGhajarKatherine BGibneyRichard FGillumIbrahim Abdelmageem MohamedGinawiMelkamu DedefoGishuGiorgiaGiussaniWilliam WGodwinKashishGoelShifalikaGoenkaEllen MGoldbergPhilimon NGonaAmadorGoodridgeSameer ValiGopalaniRichard AGosselinCarolyn CGotayAtsushiGotoAlessandra CarvalhoGoulartNicholasGraetzHarish ChanderGugnaniPrakash CGuptaRajeevGuptaTanushGuptaVipinGuptaRahulGuptaReyna AGutiérrezVladimirHachinskiNimaHafezi-NejadAlemayehu DesalegneHailuGessessew BugssaHailuRandah RibhiHamadehSamerHamidiMouhanadHammamiAlexis JHandalGraeme JHankeyYuantaoHaoHilda LHarbHabtamu AberaHareriJosep MariaHaroKimani MHarunJamesHarveyMohammad SadeghHassanvandRasmusHavmoellerSimon IHayRoderick JHayMohammad THedayatiDeliaHendrieNathaniel JHenryIleana BeatrizHeredia-PiPouriaHeydarpourHans WHoekHoward JHoffmanMasakoHorinoNobuyukiHoritaH DeanHosgoodSorinHostiucPeter JHotezDamian GHoyAung SoeHtetGuoqingHuJohn JHuangChantalHuynhKim MoesgaardIburgEhimario UcheIgumborChadIkedaCaleb Mackay SalpeterIrvineSheikh Mohammed SharifulIslamKathryn HJacobsenNaderJahanmehrMihajlo BJakovljevicPeterJamesSimerjot KJassalMehdiJavanbakhtSudha PJayaramanPanniyammakalJeemonPaul NJensenVivekanandJhaGuohongJiangDennyJohnCatherine OJohnsonSarah CharlotteJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayRitulKamalChittaranjanKarNadim EKaramAndréKarchCorine KakiziKaremaSeyed MKarimiChanteKarimkhaniAmirKasaeianGetachew MulluKassaNigussie AssefaKassawNicholas JKassebaumAnshulKastorSrinivasa VittalKatikireddiAnilKaulNoritoKawakamiPeter NjengaKeiyoroLauraKemmerAndre PascalKengneAndreKerenChandrasekharan NairKesavachandranYousef SalehKhaderIbrahim AKhalilEjaz AhmadKhanYoung-HoKhangAbdullah TKhojaArdeshirKhosraviJagdishKhubchandaniAliasghar AhmadKiadaliriChristianKielingYun JinKimDanielKimRuth WKimokotiYohannesKinfuAdnanKisaKatarzyna AKissimova-SkarbekNiranjanKissoonMikaKivimakiAnn KristinKnudsenYoshihiroKokuboDhavalKolteJacek AKopecSoewartaKosenGeorgios AKotsakisParvaiz AKoulAiKoyanagiMichaelKravchenkoKristopher JKrohnG AnilKumarPushpendraKumarHmwe HKyuAnton Carl Jo...
      PubDate: 2017-09-23T11:20:59Z
       
  • Global, regional, and national comparative risk assessment of 84
           behavioural, environmental and occupational, and metabolic risks or
           clusters of risks, 1990–2016: a systematic analysis for the Global
           Burden of Disease Study 2016
    • Authors: GBD 2016; Risk Factors CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaVictorAboyansLaith
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 Risk Factors CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahAbdishakur MAbdulleSemaw FeredeAberaVictorAboyansLaith JAbu-RaddadNiveen M EAbu-RmeilehGebre YitayihAbyuIsaac AkinkunmiAdedejiOlatunjiAdetokunbohMohsenAfaridehAshkanAfshinAnuragAgrawalSutapaAgrawalHamidAhmadiehMuktar BeshirAhmedMiloud Taki EddineAichourAmani NidhalAichourIbtihelAichourRufus OlusolaAkinyemiNadiaAkseerFaresAlahdabZiyadAl-AlyKhurshidAlamNooreAlamTahiyaAlamDeenaAlasfoorKefyalew AddisAleneKomalAliRezaAlizadeh-NavaeiAla'aAlkerwiFrançoisAllaPeterAllebeckRajaaAl-RaddadiUbaiAlsharifKhalid AAltirkawiNelsonAlvis-GuzmanAzmeraw TAmareErfanAminiWalidAmmarYaw AmpemAmoakoHosseinAnsariJosep MAntóCarl Abelardo TAntonioPalwashaAnwariNicholasArianJohanÄrnlövAlArtamanKrishna KumarAryalHamidAsayeshSolomon WeldegebrealAsgedomTesfay MehariAteyLeticiaAvila-BurgosEuripide Frinel G ArthurAvokpahoAshishAwasthiPeterAzzopardiUmarBachaAlaaBadawiKalpanaBalakrishnanShoshana HBallewAleksandraBaracRyan MBarberSuzanne LBarker-ColloTillBärnighausenSimonBarqueraLarsBarregardLope HBarreroCarolinaBatisKatherine EBattleBlair RBaumgarnerBernhard TBauneJustinBeardsleyNeerajBediEttoreBeghiMichelle LBellDerrick ABennettJames RBennettIsabela MBensenorAdugnawBerhaneDerbew FikaduBerheEduardoBernabéBalem DemtsuBetsuMirceaBeuranAddisu ShunuBeyeneAnilBhansaliZulfiqar ABhuttaBurcu KucukBicerBorisBikbovCharlesBirungiStanBiryukovChristopher DBlosserDube JaraBoneyaIbrahim RBou-OrmMichaelBrauerNicholas J KBreitbordeHermannBrennerTraolach SBrughaLemma Negesa BultoBultoZahid AButtLuceroCahuana-HurtadoRosarioCárdenasJuan JesusCarreroCarlos ACastañeda-OrjuelaFerránCatalá-LópezKellyCercyHsing-YiChangFiona JCharlsonOdgerelChimed-OchirVesper HichilombweChisumpaAbdulaal AChitheerHanneChristensenDevasahayam JesudasChristopherMassimoCirilloAaron JCohenHaleyComfortCyrusCooperJosefCoreshLeslieCornabyPaolo AngeloCortesiMichael HCriquiJohn ACrumpLalitDandonaRakhiDandonaJosédas NevesGailDaveyDragos VDavitoiuKairatDavletovBarborade CourtenBarthelemy KuateDefoLouisaDegenhardtSelinaDeiparineRobert PDellavalleKebedeDeribeAniruddhaDeshpandeSamath DDharmaratneEric LDingShirinDjalaliniaHuyen PhucDoKlaraDokovaDavid TeyeDokuAaron vanDonkelaarE RayDorseyTim RDriscollManishaDubeyBruce BartholowDuncanSarahDuncanHedyehEbrahimiZiad ZiadEl-KhatibAhmadaliEnayatiAman YesufEndriesSergey PetrovichErmakovHolly EErskineBabakEshratiShararehEskandariehAlirezaEsteghamatiKaraEstepEmerito Jose AquinoFaraonCarla Sofia e SaFarinhaAndréFaroFarshadFarzadfarKairstenFayValery LFeiginSeyed-MohammadFereshtehnejadJoão CFernandesAlize JFerrariTesfaye RegassaFeyissaIrinaFilipFlorianFischerChristinaFitzmauriceAbraham DFlaxmanNataliyaFoigtKyle JForemanJoseph JFrostadNancyFullmanThomasFürstJoao MFurtadoEmmanuelaGakidouMorsalehGanjiAlberto LGarcia-BasteiroTsegaye TeweldeGebrehiwotJohanna MGeleijnseAyeleGeletoBikila LenchaGemechuHailay AbrhaGesesewPeter WGethingAlirezaGhajarKatherine BGibneyParamjit SinghGillRichard FGillumAbabi ZergawGirefMelkamu DedefoGishuGiorgiaGiussaniWilliam WGodwinPhilimon NGonaAmadorGoodridgeSameer ValiGopalaniYevgeniyGoryakinAlessandra CarvalhoGoulartNicholasGraetzHarish ChanderGugnaniJingwenGuoRajeevGuptaTanushGuptaVipinGuptaReyna AGutiérrezVladimirHachinskiNimaHafezi-NejadGessessew BugssaHailuRandah RibhiHamadehSamerHamidiMouhanadHammamiAlexis JHandalGraeme JHankeySarah WulfHansonHilda LHarbHabtamu AberaHareriMohammad SadeghHassanvandRasmusHavmoellerCaitlinHawleySimon IHayMohammad THedayatiDeliaHendrieIleana BeatrizHeredia-PiJulio Cesar MontañezHernandezHans WHoekNobuyukiHoritaH DeanHosgoodSorinHostiucDamian GHoyMohamedHsairiGuoqingHuJohn JHuangHsiangHuangNorlinah MohamedIbrahimKim MoesgaardIburgChadIkedaManamiInoueCaleb Mackay SalpeterIrvineMaria DeloresJacksonKathryn HJacobsenNaderJahanmehrMihajlo BJakovljevicAlejandraJaureguiMehdiJavanbakhtPanniyammakalJeemonLars R KJohanssonCatherine OJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayRitulKamalAndréKarchCorine KakiziKaremaAmirKasaeianNicholas JKassebaumAnshulKastorSrinivasa VittalKatikireddiNoritoKawakamiPeter NjengaKeiyoroSefonias GetachewKelboreLauraKemmerAndre PascalKengneChandrasekharan NairKesavachandranYousef SalehKhaderIbrahim AKhalilEjaz AhmadKhanYoung-HoKhangArdeshirKhosraviJagdishKhubchandaniAliasghar AhmadKiadaliriChristianKielingJun YKimYun JinKimDanielKimRuth WKimokotiYohannesKinfuAdnanKisaKatarzyna AKissimova-SkarbekMikaKivimakiLuke DKnibbsAnn KristinKnudsenJacek AKopecSoewartaKosenParvaiz AKoulAiKoyanagiMichaelKravchenkoKristopher JKrohnHansKromhoutG AnilKumarMichaelKutzHmwe HKyuDharmesh KumarLalRatilalLallooTeaLallukkaQingLanVan CLansinghAndersLarssonPaul HLeeAlexanderLeeJamesLeighJanniLeungMiriamLeviTeresa ShamahLevyYichongLiYongmeiLiXiaofengLiangMisgan LegesseLibenStephen SLimShaiLinnPatrickLiuRakeshLodhaGiancarloLogroscinoKatherine JLookerAlan DLopezStefanLorkowskiPaulo ALotufoRafaelLozanoRaimundasLuneviciusErlyn Rachelle KingMacarayanHassanMagdy Abd El RazekMohammedMagdy Abd El RazekMarekMajdanRezaMajdzadehAzeemMajeedRezaMalekzadehRajeshMalhotraDeborah CarvalhoMaltaAbdullah AMamunHelenaManguerraLorenzo GMantovaniChabila CMapomaRandall VMartinJoseMartinez-RagaFrancisco RogerlândioMartins-MeloManu RajMathurKunihiroMatsushitaRichardMatzopoulosMohsenMazidiColmMcAlindenJohn JMcGrathSureshMehataMan MohanMehndirattaToniMeierYohannes AdamaMelakuPeterMemiahZiad AMemishWalterMendozaMelkamu MeridMengeshaGeorge AMensahGert B MMensinkSeid TikuMeretaTuomo JMeretojaAtteMeretojaHaftay BerhaneMezgebeRenataMichaAnoushkaMillearTed RMillerShawnMinnigMojdeMirarefinErkin MMirrakhimovAwokeMisganawShiva RajMishraKarzan AbdulmuhsinMohammadKedir EndrisMohammedShafiuMohammedMurali B VMohanAli HMokdadLorenzoMonastaMarcellaMonticoMaziarMora...
      PubDate: 2017-09-23T11:20:59Z
       
  • Measuring progress and projecting attainment on the basis of past trends
           of the health-related Sustainable Development Goals in 188 countries: an
           analysis from the Global Burden of Disease Study 2016
    • Authors: GBD 2016; SDG CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan SuliankatchiAbdulkaderAbdishakur MAbdulleSemaw FeredeAberaVictorAboyansLaith
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): GBD 2016 SDG CollaboratorsAmanuel AlemuAbajobirKalkidan HassenAbateCristianaAbbafatiKaja MAbbasFoadAbd-AllahRizwan SuliankatchiAbdulkaderAbdishakur MAbdulleSemaw FeredeAberaVictorAboyansLaith JAbu-RaddadNiveen M EAbu-RmeilehIsaac AkinkunmiAdedejiOlatunjiAdetokunbohAshkanAfshinAnuragAgrawalSutapaAgrawalAliasgharAhmad KiadaliriHamidAhmadiehMuktar BeshirAhmedMiloud Taki EddineAichourAmani NidhalAichourIbtihelAichourSnehaAiyarRufus OlusolaAkinyemiNadiaAkseerZiyadAl-AlyKhurshidAlamNooreAlamDeenaAlasfoorKefyalew AddisAleneRezaAlizadeh-NavaeiAla'aAlkerwiFrançoisAllaPeterAllebeckChristineAllenRajaaAl-RaddadiUbaiAlsharifKhalid AAltirkawiNelsonAlvis-GuzmanAzmeraw TAmareErfanAminiWalidAmmarHosseinAnsariCarl Abelardo TAntonioPalwashaAnwariMeghaAroraAlArtamanKrishna KumarAryalHamidAsayeshSolomon WeldegebrealAsgedomRezaAssadiTesfay MehariAteySachin RAtreLeticiaAvila-BurgosEuripide Frinel G ArthurAvokpahoAshishAwasthiPeterAzzopardiUmarBachaAlaaBadawiKalpanaBalakrishnanMarlena SBannickAleksandraBaracRyan MBarberSuzanne LBarker-ColloTillBärnighausenLope HBarreroSanjayBasuKatherine EBattleBernhard TBauneJustinBeardsleyNeerajBediEttoreBeghiYannickBéjotMichelle LBellDerrick ABennettJames RBennettIsabela MBensenorAdugnawBerhaneDerbew FikaduBerheEduardoBernabéBalem DemtsuBetsuMirceaBeuranAddisu ShunuBeyeneNeerajBhalaAnilBhansaliSamirBhattZulfiqar ABhuttaBurcu KucukBicerHassan HaghparastBidgoliBorisBikbovArebu IBilalCharlesBirungiStanBiryukovHabtamu MellieBizuayehuChristopher DBlosserDube JaraBoneyaDipanBoseIbrahim RBou-OrmMichaelBrauerNicholas J KBreitbordeTraolach SBrughaLemma Negesa BultoBultoZahid AButtLuceroCahuana-HurtadoEwanCameronJulio CesarCampuzanoHélèneCarabinRosarioCárdenasJuan JesusCarreroAustinCarterDaniel CCaseyCarlos ACastañeda-OrjuelaRuben EstanislaoCastroFerránCatalá-LópezKellyCercyHsing-YiChangJung-ChenChangFiona JCharlsonAdrienneChewVesper HichilombweChisumpaAbdulaal AChitheerHanneChristensenDevasahayam JesudasChristopherMassimoCirilloCyrusCooperMichael HCriquiElizabeth ACromwellJohn ACrumpLalitDandonaRakhiDandonaPaul IDarganJosédas NevesDragos VDavitoiuBarborade CourtenHansDe SteurBarthelemy KuateDefoLouisaDegenhardtSelinaDeiparineKebedeDeribeGabrielle AdeVeberEric LDingShirinDjalaliniaHuyen PhucDoKlaraDokovaDavid TeyeDokuAaron vanDonkelaarE RayDorseyTim RDriscollManishaDubeyBruce BartholowDuncanBeth EEbelHedyehEbrahimiZiad ZiadEl-KhatibAhmadaliEnayatiAman YesufEndriesSergey PetrovichErmakovHolly EErskineBabakEshratiShararehEskandariehAlirezaEsteghamatiKaraEstepEmerito Jose AquinoFaraonCarla Sofia e SaFarinhaAndréFaroFarshadFarzadfarMir SohailFazeliValery LFeiginAndrea BFeiglSeyed-MohammadFereshtehnejadJoão CFernandesAlize JFerrariTesfaye RegassaFeyissaIrinaFilipFlorianFischerChristinaFitzmauriceAbraham DFlaxmanNataliyaFoigtKyle JForemanTahviFrankRichard CFranklinJosephFriedmanJoseph JFrostadNancyFullmanThomasFürstJoao MFurtadoEmmanuelaGakidouAlberto LGarcia-BasteiroTsegaye TeweldeGebrehiwotJohanna MGeleijnseAyeleGeletoBikila LenchaGemechuPeter WGethingKatherine BGibneyParamjit SinghGillRichard FGillumAbabi ZergawGirefMelkamu DedefoGishuGiorgiaGiussaniScott DGlennWilliam WGodwinEllen MGoldbergPhilimon NGonaAmadorGoodridgeSameer ValiGopalaniYevgeniyGoryakinMaxGriswoldHarish ChanderGugnaniRajeevGuptaTanushGuptaVipinGuptaNimaHafezi-NejadGessessew BugssaHailuRandah RibhiHamadehMouhanadHammamiGraeme JHankeyHilda LHarbHabtamu AberaHareriMohammad SadeghHassanvandRasmusHavmoellerCaitlinHawleySimon IHayJiaweiHeDeliaHendrieNathaniel JHenryIleana BeatrizHeredia-PiHans WHoekMollieHolmbergNobuyukiHoritaH DeanHosgoodSorinHostiucDamian GHoyMohamedHsairiAung SoeHtetJohn JHuangHsiangHuangChantalHuynhKim MoesgaardIburgChadIkedaManamiInoueCaleb Mackay SalpeterIrvineKathryn HJacobsenNaderJahanmehrMihajlo BJakovljevicAlejandraJaureguiMehdiJavanbakhtPanniyammakalJeemonVivekanandJhaDennyJohnCatherine OJohnsonSarah CharlotteJohnsonJost BJonasMikkJürissonZubairKabirRajendraKadelAmahaKahsayRitulKamalAndréKarchCorine KakiziKaremaAmirKasaeianNicholas JKassebaumAnshulKastorSrinivasa VittalKatikireddiNoritoKawakamiPeter NjengaKeiyoroSefonias GetachewKelboreLauraKemmerAndre PascalKengneChandrasekharan NairKesavachandranYousef SalehKhaderIbrahim AKhalilEjaz AhmadKhanYoung-HoKhangArdeshirKhosraviJagdishKhubchandaniChristianKielingJun YKimYun JinKimDanielKimRuth WKimokotiYohannesKinfuAdnanKisaKatarzyna AKissimova-SkarbekMikaKivimakiYoshihiroKokuboJacek AKopecSoewartaKosenParvaiz AKoulAiKoyanagiMichaelKravchenkoKristopher JKrohnXie RachelKulikoffG AnilKumarDharmeshKumar LalMichael JKutzHmwe HKyuRatilalLallooVan CLansinghAndersLarssonJeffrey VictorLazarusPaul HLeeJamesLeighJanniLeungRickyLeungMiriamLeviYongmeiLiMisgan LegesseLibenStephen SLimShaiLinnPatrick YLiuShiweiLiuRakeshLodhaKatharine JLookerAlan DLopezStefanLorkowskiPaulo ALotufoRafaelLozanoTimothy C DLucasRaimundasLuneviciusMark TMackayEmilie RMaddisonHassanMagdy Abd El RazekMohammedMagdy Abd El RazekMarekMajdanRezaMajdzadehAzeemMajeedRezaMalekzadehRajeshMalhotraDeborah CarvalhoMaltaAbdullah AMamunHelenaManguerraLorenzo GMantovaniTsegahunManyazewalChabila CMapomaGuy BMarksRandall VMartinJoseMartinez-RagaFrancisco RogerlândioMartins-MeloIraMartopulloManu RajMathurMohsenMazidiColmMcAlindenMadelineMcGaugheyJohn JMcGrathMartinMcKeeSureshMehataMan MohanMehndirattaToniMeierKidanu GebremariamMelesZiad AMemishWalterMendozaMelkamu MeridMengeshaMubarek AberaMengistieGeorge AMensahGert B MMensinkSeid TikuMeretaTuomo JMeretojaAtteMeretojaHaftay BerhaneMezgebeRenataMichaAnoushkaMillearTed RMillerShawnMinnigMojdeMirarefinErkin MMirrakhimovAwokeMisganawShiva RajMishraPhilip BMitchellKarzan AbdulmuhsinMohammadKedir EndrisMohammedShafiuMohammedMurali B VMohanAli HMokdadSarah KMollenkopfLorenzoMonastaJulio CesarMontañez HernandezMarcellaMonticoMaziar...
      PubDate: 2017-09-23T11:20:59Z
       
  • Life, death, and disability in 2016
    • Authors: Lancet
      Abstract: Publication date: 16–22 September 2017
      Source:The Lancet, Volume 390, Issue 10100
      Author(s): The Lancet


      PubDate: 2017-09-17T14:17:37Z
       
  • Betty Kirkwood: trailblazer in global health epidemiology
    • Authors: Richard Lane
      Abstract: Publication date: Available online 13 September 2017
      Source:The Lancet
      Author(s): Richard Lane


      PubDate: 2017-09-17T14:17:37Z
      DOI: 10.1016/s0140-6736(17)32361-9
       
  • Ann Ashworth: pioneer in child nutrition
    • Authors: Richard Lane
      Abstract: Publication date: Available online 13 September 2017
      Source:The Lancet
      Author(s): Richard Lane


      PubDate: 2017-09-17T14:17:37Z
      DOI: 10.1016/s0140-6736(17)32360-7
       
 
 
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