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Journal Cover Science
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     ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
     Published by American Association for the Advancement of Science (AAAS) Homepage  [3 journals]   [SJR: 10.618]   [H-I: 739]
  • [Podcast] Science Podcast: 21 November Show
    • Abstract: On this week's show: Neurosexism and a news roundup.
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.1016-b
  • [Working Life] The winding road
    • Authors: Ranjan Mukherjee
      Abstract: Author: Ranjan Mukherjee
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.1026
  • [Errata] Erratum for the Report: “Washing away your sins: Threatened
           morality and physical cleansing” by C.-B. Zhong and K. Liljenquist
    • PubDate: 2014-11-21
      DOI: 10.1126/science.aaa2510
  • [Report] Convergent evolution of complex regulatory landscapes and
           pleiotropy at Hox loci
    • Authors: Nicolas Lonfat
      Abstract: The enhancer landscape controlling Hoxd genes in digit and external genital cells is the same.
      Authors : Nicolas Lonfat, Thomas Montavon, Fabrice Darbellay, Sandra Gitto, Denis Duboule
      PubDate: 2014-11-21
      DOI: 10.1126/science.1257493
  • [Report] Mouse regulatory DNA landscapes reveal global principles of
           cis-regulatory evolution
    • Authors: Jeff Vierstra
      Abstract: Mouse-to-human genomic comparisons illuminate conserved transcriptional programs despite regulatory rewiring.
      Authors : Jeff Vierstra, Eric Rynes, Richard Sandstrom, Miaohua Zhang, Theresa Canfield, R. Scott Hansen, Sandra Stehling-Sun, Peter J. Sabo, Rachel Byron, Richard Humbert, Robert E. Thurman, Audra K. Johnson, Shinny Vong, Kristen Lee, Daniel Bates, Fidencio Neri, Morgan Diegel, Erika Giste, Eric Haugen, Douglas Dunn, Matthew S. Wilken, Steven Josefowicz, Robert Samstein, Kai-Hsin Chang, Evan E. Eichler, Marella De Bruijn, Thomas A. Reh, Arthur Skoultchi, Alexander Rudensky, Stuart H. Orkin, Thalia Papayannopoulou, Piper M. Treuting, Licia Selleri, Rajinder Kaul, Mark Groudine, M. A. Bender, John A. Stamatoyannopoulos
      PubDate: 2014-11-21
      DOI: 10.1126/science.1246426
  • [Business Office Feature] The art of culture: Developing cell lines
    • Authors: Alan Dove
      Abstract: Alan Dove
      Keywords: Business Office Feature
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.1013
  • [New Products] New Products
    • Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.1016-a
  • [Special Issue Review] Dialogue between skin microbiota and immunity
    • Authors: Yasmine Belkaid
      Abstract: Human skin, the body’s largest organ, functions as a physical barrier to bar the entry of foreign pathogens, while concomitantly providing a home to myriad commensals. Over a human’s life span, keratinized skin cells, immune cells, and microbes all interact to integrate the processes of maintaining skin’s physical and immune barrier under homeostatic healthy conditions and also under multiple stresses, such as wounding or infection. In this Review, we explore the intricate interactions of microbes and immune cells on the skin surface and within associated appendages to regulate this orchestrated maturation in the context of both host physiological changes and environmental challenges.
      Authors : Yasmine Belkaid, Julia A. Segre
      PubDate: 2014-11-21
      DOI: 10.1126/science.1260144
  • This Week in Science
    • Authors: Brent Grocholski
      Abstract: Tibetan gorge avoids a tectonic aneurysm A cohesin ring around two DNA strands Compensating optical loss for laser gain Containing the nuclear elephant's foot Recharging Ebola mitigation measures Using a diabetes drug to treat tuberculosis Transit marked by magnetosphere effects Making the brain promote fat loss in mice Hills and valleys of influenza infection Variety of Ebola symptoms in mice HIV drugs can dampen inflammation, too Similar regulation of digit and genital development Rewiring the gene regulatory landscape How a fungus can live for centuries
      Keywords: Geomorphology
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.960-a
  • Editors' Choice
    • Authors: Caroline Ash
      Abstract: Mycoplasma doubles the cost of an STD Disorder enhances binding cooperativity Climbing up the walls like a gecko Symmetric photons make good communicators Dark matter may yield x-ray glow nearby Redox regulation of Lon protease Follow scientists, not the lab notebook A (w)holistic approach to track T cells
      Keywords: Microbiology
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.961-a
  • [Research Article] Closing the cohesin ring: Structure and function of its
           Smc3-kleisin interface
    • Authors: Thomas G. Gligoris
      Abstract: The presence of a DNA “exit gate” in a tripartite ring of proteins confirms that the ring holds together sister chromatid DNA strands.
      Authors : Thomas G. Gligoris, Johanna C. Scheinost, Frank Bürmann, Naomi Petela, Kok-Lung Chan, Pelin Uluocak, Frédéric Beckouët, Stephan Gruber, Kim Nasmyth, Jan Löwe
      PubDate: 2014-11-21
      DOI: 10.1126/science.1256917
  • [Research Article] Characterization of a DNA exit gate in the human
           cohesin ring
    • Authors: Pim J. Huis in ’t Veld
      Abstract: The presence of a DNA “exit gate” in a tripartite ring of proteins confirms the ring holds together sister chromatid DNA strands.
      Authors : Pim J. Huis in ’t Veld, Franz Herzog, Rene Ladurner, Iain F. Davidson, Sabina Piric, Emanuel Kreidl, Venugopal Bhaskara, Ruedi Aebersold, Jan-Michael Peters
      PubDate: 2014-11-21
      DOI: 10.1126/science.1256904
  • [Special Issue Review] The gentle touch receptors of mammalian skin
    • Authors: Amanda Zimmerman
      Abstract: The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch information to the central nervous system. Touch sensations are conveyed by distinct combinations of mechanosensory end organs and the low-threshold mechanoreceptors (LTMRs) that innervate them. Here we explore the various structures underlying the diverse functions of cutaneous LTMR end organs. Beyond anchoring of LTMRs to the surrounding dermis and epidermis, recent evidence suggests that the non-neuronal components of end organs play an active role in signaling to LTMRs and may physically gate force-sensitive channels in these receptors. Combined with LTMR intrinsic properties, the balance of these factors comprises the response properties of mechanosensory neurons and, thus, the neural encoding of touch.
      Authors : Amanda Zimmerman, Ling Bai, David D. Ginty
      PubDate: 2014-11-21
      DOI: 10.1126/science.1254229
  • [Report] Antibody landscapes after influenza virus infection or
    • Authors: J. M. Fonville
      Abstract: Preemptive vaccine updates may substantially improve influenza vaccine efficacy in previously exposed individuals. [Also see Perspective by Lessler]
      Authors : J. M. Fonville, S. H. Wilks, S. L. James, A. Fox, M. Ventresca, M. Aban, L. Xue, T. C. Jones, Le N. M. H., Pham Q. T., Tran N. D., Y. Wong, A. Mosterin, L. C. Katzelnick, D. Labonte, Le T. T., G. van der Net, E. Skepner, C. A. Russell, T. D. Kaplan, G. F. Rimmelzwaan, N. Masurel, J. C. de Jong, A. Palache, W. E. P. Beyer, Le Q. M., Nguyen T. H., H. F. L. Wertheim, A. C. Hurt, A. D. M. E. Osterhaus, I. G. Barr, R. A. M. Fouchier, P. W. Horby, D. J. Smith
      PubDate: 2014-11-21
      DOI: 10.1126/science.1256427
  • [Report] Nucleoside reverse transcriptase inhibitors possess intrinsic
           anti-inflammatory activity
    • Authors: Benjamin J. Fowler
      Abstract: Anti-HIV nucleoside analogs treat retinal degeneration and graft-versus-host disease in mice.
      Authors : Benjamin J. Fowler, Bradley D. Gelfand, Younghee Kim, Nagaraj Kerur, Valeria Tarallo, Yoshio Hirano, Shoba Amarnath, Daniel H. Fowler, Marta Radwan, Mark T. Young, Keir Pittman, Paul Kubes, Hitesh K. Agarwal, Keykavous Parang, David R. Hinton, Ana Bastos-Carvalho, Shengjian Li, Tetsuhiro Yasuma, Takeshi Mizutani, Reo Yasuma, Charles Wright, Jayakrishna Ambati
      PubDate: 2014-11-21
      DOI: 10.1126/science.1261754
  • [Special Issue Review] The melanoma revolution: From UV carcinogenesis to
           a new era in therapeutics
    • Authors: Jennifer A. Lo
      Abstract: Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in incidence. Although melanoma is a historically treatment-resistant malignancy, in recent years unprecedented breakthroughs in targeted therapies and immunotherapies have revolutionized the standard of care for patients with advanced disease. Here, we provide an overview of recent developments in our understanding of melanoma risk factors, genomics, and molecular pathogenesis and how these insights have driven advances in melanoma treatment. In addition, we review benefits and limitations of current therapies and look ahead to continued progress in melanoma prevention and therapy. Remarkable achievements in the field have already produced a paradigm shift in melanoma treatment: Metastatic melanoma, once considered incurable, can now be treated with potentially curative rather than palliative intent.
      Authors : Jennifer A. Lo, David E. Fisher
      PubDate: 2014-11-21
      DOI: 10.1126/science.1253735
  • [Special Issue Review] Advances in skin grafting and treatment of
           cutaneous wounds
    • Authors: Bryan K. Sun
      Abstract: The ability of the skin to repair itself after injury is vital to human survival and is disrupted in a spectrum of disorders. The process of cutaneous wound healing is complex, requiring a coordinated response by immune cells, hematopoietic cells, and resident cells of the skin. We review the classic paradigms of wound healing and evaluate how recent discoveries have enriched our understanding of this process. We evaluate current and experimental approaches to treating cutaneous wounds, with an emphasis on cell-based therapies and skin transplantation.
      Authors : Bryan K. Sun, Zurab Siprashvili, Paul A. Khavari
      PubDate: 2014-11-21
      DOI: 10.1126/science.1253836
  • [Letter] Rewarding academic innovation
    • Authors: Paul R. Sanberg
      Authors : Paul R. Sanberg, Judy Genshaft, Sudeep Sarkar
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.928-c
  • [Letter] Older scientists get their due
    • Authors: K. Brad Wray
      Abstract: Author: K. Brad Wray
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.929
  • [Introduction to Special Issue] From bench to bedside
    • Authors: Stella Hurtley
      Abstract: From bench to bedside
      Authors : Stella Hurtley, Pamela J. Hines, Kristen L. Mueller, Elizabeth Culotta
      Keywords: Skin
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.932
  • [Special Issue News] Shedding light on skin color
    • Authors: Ann Gibbons
      Abstract: Nina Jablonski explores how it evolved—and what happens when it does not match the environment. Author: Ann Gibbons
      Keywords: Skin
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.934
  • [Special Issue Review] Mammalian skin cell biology: At the interface
           between laboratory and clinic
    • Authors: Fiona M. Watt
      Abstract: Mammalian skin research represents the convergence of three complementary disciplines: cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current research in cell adhesion, inflammation, and tissue stem cells. Here, I discuss recent insights into the cell biology of skin. Single-cell analysis has revealed that human epidermal stem cells are heterogeneous and differentiate in response to multiple extrinsic signals. Live-cell imaging, optogenetics, and cell ablation experiments show skin cells to be remarkably dynamic. High-throughput, genome-wide approaches have yielded unprecedented insights into the circuitry that controls epidermal stem cell fate. Last, integrative biological analysis of human skin disorders has revealed unexpected functions for elements of the skin that were previously considered purely structural. Author: Fiona M. Watt
      PubDate: 2014-11-21
      DOI: 10.1126/science.1253734
  • [Book Review] A walk on the wild side
    • Authors: Christine Griffiths
      Abstract: Author: Christine Griffiths
      Keywords: Restoration Ecology
      PubDate: 2014-11-21
      DOI: 10.1126/science.1262000
  • [Book Review] Steampunk science
    • Authors: Deborah Dixon
      Abstract: Author: Deborah Dixon
      Keywords: Exhibition
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa0415
  • [Books et al.] Books Received
    • Abstract: A listing of books received at Science during the week ending 14 November 2014.
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.926-b
  • [Letter] Tropical crops: Cautious optimism
    • Authors: Xingli Giam
      Authors : Xingli Giam, Lian Pin Koh, David S. Wilcove
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.928-a
  • [Letter] Tropical crops: Cautious optimism—Response
    • Authors: L. R. Carrasco
      Authors : L. R. Carrasco, C. Larrosa, E. J. Milner-Gulland, D. P. Edwards
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.928-b
  • [Perspective] Can erosion drive tectonics?
    • Authors: Kelin X. Whipple
      Abstract: Data from the eastern Himalaya challenge the idea that climate-driven erosion can control tectonics [Also see Report by Wang et al.] Author: Kelin X. Whipple
      Keywords: Geophysics
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa0887
  • [Perspective] Charting the life-course epidemiology of influenza
    • Authors: Justin Lessler
      Abstract: How does influenza immunity develop over one's lifetime? [Also see Report by Fonville et al.] Author: Justin Lessler
      Keywords: Immunology
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa0613
  • [Perspective] Temporal targets of drug action
    • Authors: Garret A. FitzGerald
      Abstract: A circadian gene expression atlas shows that time of day is relevant to the oscillation of drug targets and the effects of medications Author: Garret A. FitzGerald
      Keywords: Circadian Rhythms
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa2285
  • [Perspective] How a long-lived fungus keeps mutations in check
    • Authors: Duur K. Aanen
      Abstract: Specific mechanisms of somatic growth protect long-lived fungi and plants from deleterious mutations Author: Duur K. Aanen
      Keywords: Developmental Biology
      PubDate: 2014-11-21
      DOI: 10.1126/science.1261401
  • [Feature] A dose of reality
    • Authors: Jon Cohen
      Abstract: Does any treatment work against Ebola? Researchers may soon find out, if they can overcome daunting ethical and practical challenges.
      Authors : Jon Cohen, Kai Kupferschmidt
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.908
  • [Feature] Saving lives without new drugs
    • Authors: Jon Cohen
      Abstract: A push for improving basic care of Ebola patients could save many lives without experimental treatments. Author: Jon Cohen
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.911
  • [Policy Forum] Rethinking China's new great wall
    • Authors: Zhijun Ma
      Abstract: Massive seawall construction in coastal wetlands threatens biodiversity
      Authors : Zhijun Ma, David S. Melville, Jianguo Liu, Ying Chen, Hongyan Yang, Wenwei Ren, Zhengwang Zhang, Theunis Piersma, Bo Li
      Keywords: Ecosystems Management
      PubDate: 2014-11-21
      DOI: 10.1126/science.1257258
  • [Perspective] His brain, her brain?
    • Authors: Cordelia Fine
      Abstract: Research exploring sex differences in the human brain must overcome “neurosexist” interpretations Author: Cordelia Fine
      Keywords: Neuroscience
      PubDate: 2014-11-21
      DOI: 10.1126/science.1262061
  • [Perspective] Taking the measure of molten uranium oxide
    • Authors: Alexandra Navrotsky
      Abstract: Levitated droplets of uranium oxide reveal a complex structure below and above the melting point [Also see Report by Skinner et al.] Author: Alexandra Navrotsky
      Keywords: Nuclear Materials
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa0163
  • [In Depth] New support for ‘gay gene’
    • Authors: Kelly Servick
      Abstract: Replication of 1993 study highlights same region on X chromosome, but some still call evidence inconclusive. Author: Kelly Servick
      Keywords: Human Behavior
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.902
  • [In Depth] China's peak carbon pledge raises pointed questions
    • Authors: David Malakoff
      Abstract: Modelers move to analyze implications of largest emitter's commitment to stabilize emissions by 2030. Author: David Malakoff
      Keywords: Climate Policy
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.903
  • [In Depth] Exit of E.U. science adviser triggers furor
    • Authors: Tania Rabesandratana
      Abstract: New European Commission says it hasn't decided how it will organize its scientific advice. Author: Tania Rabesandratana
      Keywords: Europe
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.904
  • [Feature] The mystery of the dead galaxies
    • Authors: Ann Finkbeiner
      Abstract: Astronomers thought they knew why all galaxies eventually redden and die. They were wrong. Author: Ann Finkbeiner
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.905
  • [Report] Magnetic moment and plasma environment of HD 209458b as
           determined from Lyα observations
    • Authors: Kristina G. Kislyakova
      Abstract: An exoplanet’s magnetic field is manifested as a particular absorption pattern in the transmitted spectrum of the host star.
      Authors : Kristina G. Kislyakova, Mats Holmström, Helmut Lammer, Petra Odert, Maxim L. Khodachenko
      PubDate: 2014-11-21
      DOI: 10.1126/science.1257829
  • [Report] Molten uranium dioxide structure and dynamics
    • Authors: L. B. Skinner
      Abstract: Levitation of molten uranium dioxide allowed structural determination of the solid and melt at high temperature. [Also see Perspective by Navrotsky]
      Authors : L. B. Skinner, C. J. Benmore, J. K. R. Weber, M. A. Williamson, A. Tamalonis, A. Hebden, T. Wiencek, O. L. G. Alderman, M. Guthrie, L. Leibowitz, J. B. Parise
      PubDate: 2014-11-21
      DOI: 10.1126/science.1259709
  • [Report] Host genetic diversity enables Ebola hemorrhagic fever
           pathogenesis and resistance
    • Authors: Angela L. Rasmussen
      Abstract: Intercrossed mice infected with Ebola virus show a spectrum of pathology from prolonged coagulation to total resistance.
      Authors : Angela L. Rasmussen, Atsushi Okumura, Martin T. Ferris, Richard Green, Friederike Feldmann, Sara M. Kelly, Dana P. Scott, David Safronetz, Elaine Haddock, Rachel LaCasse, Matthew J. Thomas, Pavel Sova, Victoria S. Carter, Jeffrey M. Weiss, Darla R. Miller, Ginger D. Shaw, Marcus J. Korth, Mark T. Heise, Ralph S. Baric, Fernando Pardo-Manuel de Villena, Heinz Feldmann, Michael G. Katze
      PubDate: 2014-11-21
      DOI: 10.1126/science.1259595
  • [Report] Strategies for containing Ebola in West Africa
    • Authors: Abhishek Pandey
      Abstract: A combination of hygienic practices could feasibly check Ebola within 6 months.
      Authors : Abhishek Pandey, Katherine E. Atkins, Jan Medlock, Natasha Wenzel, Jeffrey P. Townsend, James E. Childs, Tolbert G. Nyenswah, Martial L. Ndeffo-Mbah, Alison P. Galvani
      PubDate: 2014-11-21
      DOI: 10.1126/science.1260612
  • [Report] Single-mode laser by parity-time symmetry breaking
    • Authors: Liang Feng
      Abstract: The interplay between gain and loss can provide a route to control laser emission.
      Authors : Liang Feng, Zi Jing Wong, Ren-Min Ma, Yuan Wang, Xiang Zhang
      PubDate: 2014-11-21
      DOI: 10.1126/science.1258479
  • [Report] Parity-time–symmetric microring lasers
    • Authors: Hossein Hodaei
      Abstract: The interplay between gain and loss can provide a route to control laser emission.
      Authors : Hossein Hodaei, Mohammad-Ali Miri, Matthias Heinrich, Demetrios N. Christodoulides, Mercedeh Khajavikhan
      PubDate: 2014-11-21
      DOI: 10.1126/science.1258480
  • [Report] Tectonic control of Yarlung Tsangpo Gorge revealed by a buried
           canyon in Southern Tibet
    • Authors: Ping Wang
      Abstract: Sediment cores from a buried canyon upstream of the Tsangpo Gorge support a rapid uplift event to explain gorge formation. [Also see Perspective by Whipple]
      Authors : Ping Wang, Dirk Scherler, Jing Liu-Zeng, Jürgen Mey, Jean-Philippe Avouac, Yunda Zhang, Dingguo Shi
      PubDate: 2014-11-21
      DOI: 10.1126/science.1259041
  • [Editorial] More Science in the Classroom
    • Authors: Marcia McNutt
      Abstract: About a year ago, Bruce Alberts and I announced the launch of Science in the Classroom (, an online resource of annotated research papers published in Science, with associated teaching materials designed to help pre-college and college students understand how science moves forward as a structured way of revealing the laws of nature. Since its fledgling beginning last year, the project has expanded its subject diversity and continues to add articles at the rate of two per month. These articles have reached about 3000 users per month. But now it is time to take this project to the next level—and you can help, by annotating new papers and designing creative activities to accompany them. Author: Marcia McNutt
      PubDate: 2014-11-21
      DOI: 10.1126/science.aaa1728
  • [In Brief] This week's section
    • Abstract: A roundup of weekly science policy and related news.
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.898
  • [In Depth] Philae probe makes bumpy touchdown on a comet
    • Authors: Eric Hand
      Abstract: Elation and disappointment as lander goes into early hibernation, curtailing experiments. Author: Eric Hand
      Keywords: Planetary Science
      PubDate: 2014-11-21
      DOI: 10.1126/science.346.6212.900
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