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Science    [1466 followers]  Follow    
  Full-text available via subscription Subscription journal
     ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
     Published by American Association for the Advancement of Science (AAAS) Homepage  [3 journals]   [SJR: 10.618]   [H-I: 739]
  • This Week in Science
    • Abstract: Altitude Sickness A Soft Molecular Spring Nanoimaged Polaritons Limited Stability Crossing the Membrane Evolutionary Duality Carbapenems Through the Looking Glass Persistent Plume Keeping HIV at Bay? River Reorganization Immune Variation Plant Epigenetics
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1055-a
  • [Editorial] Crystallography and Geopolitics
    • Authors: Gautam R. Desiraju
      Abstract: Developed and Developing Nations Recognize that Innovation is Key to their Economies. Connecting this with the discipline of crystallography may not seem immediately apparent, but during the past century, understanding the structure of matter has transformed industries and created new frontiers, from the design of new medicines and materials to assessing the mineral content of Mars. The future global economy will be determined by progress in cutting-edge fields. However, the playing field is not level in crystallography, which is why the International Union of Crystallography (IUCr) and the United Nations Educational, Scientific and Cultural Organization (UNESCO) have marked 2014 as the International Year of Crystallography. The aim is to improve public awareness of the field, boost access to instrumentation and high-level research, nurture “home-grown” crystallographers in developing nations, and increase international collaborations for the benefit of future generations. Author: Gautam R. Desiraju
      PubDate: 2014-03-07
      DOI: 10.1126/science.1252187
  • Editors' Choice
    • Authors: Caroline Ash
      Abstract: Opening Pandora's Box A Better-Known Electron Mass Highly Reactive Abasic DNA Aging Nucleosomes Metastasis in the Light Synthetic Controls Methylation Sees the Light
      Keywords: Virology
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1058-a
  • [News of the Week] This Week's Section
    • Abstract: Follow the links below for a roundup of the week's top stories in science, or download a PDF of the entire section. Around the WorldFindingsRandom SamplesNewsmakers
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1062-a
  • [News of the Week] Around the World
    • Abstract: In science news around the world, scientists find Middle East respiratory syndrome in camels from Africa; Japan launches a test of a space debris cleanup scheme; the U.S. Environmental Protection Agency halts the permit for a large copper mine near Bristol Bay, Alaska; and more.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1062-b
  • [News of the Week] Random Sample
    • Abstract: Researchers interested in studying and preventing strokes have their eye on the capybara. The world's largest rodent shuts off a main blood supply to its brain, then manages to compensate by expanding another artery.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1062-c
  • [News of the Week] Newsmakers
    • Abstract: Theoretical physicist-turned-filmmaker Mark Levinson tells Science about directing Particle Fever, a new documentary on the discovery of the Higgs boson.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1064-a
  • Findings
    • Abstract: Viruses on Ice for Millennia Still Infectious
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1064-b
  • [News & Analysis] Sabotaged Scientist Sues Yale and Her Lab Chief
    • Authors: Martin Enserink
      Abstract: Lawsuit claims that research leader retaliated against the victim after misconduct was discovered. Author: Martin Enserink
      Keywords: Scientific Misconduct
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1065
  • [News & Analysis] A Bid to Thwart HIV With Shot of Long-Lasting Drug
    • Authors: Jon Cohen
      Abstract: Four shots a year with a long-lasting drug may prevent HIV infection in the future. Author: Jon Cohen
      Keywords: Virology
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1067
  • [News & Analysis] Diet Studies Challenge Thinking on Proteins Versus
    • Authors: Jennifer Couzin-Frankel
      Abstract: New data on mice and people suggest low-protein diets enhance health and extend life. Author: Jennifer Couzin-Frankel
      Keywords: Nutrition
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1068
  • [News & Analysis] Major Conservation Group Guts Science Team in
           Strategy Shift
    • Authors: Erik Stokstad
      Abstract: Laying off staff scientists, the World Wildlife Fund moves away from centralized research to rely more on outsourced expertise. Author: Erik Stokstad
      Keywords: Environment
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1069
  • [News & Analysis] Chemical Atlas Shows Where Seas Are
           Tainted—And Where They Can Bloom
    • Authors: David Malakoff
      Abstract: Oceanographers have released a digital atlas containing remarkably detailed maps of ocean chemistry. Author: David Malakoff
      Keywords: Oceanography
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1070
  • [News & Analysis] Europe's Copernicus Offers a Daily Dose of Earth
    • Authors: Daniel Clery
      Abstract: Early in April, Europe will launch the first satellite in its Copernicus program: a fleet of a dozen environmental monitoring spacecraft designed to study Earth's oceans, changes in land use, and atmosphere. Author: Daniel Clery
      Keywords: Space
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1071
  • [News Focus] Structural Biology Scales Down
    • Authors: Robert F. Service
      Abstract: The United States is winding down a $1 billion project to churn out protein structures. What will that mean for the field? Author: Robert F. Service
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1072
  • [Letter] Small Telescopes, Big Rewards
    • Authors: William Bruce Weaver
      Abstract: Author: William Bruce Weaver
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1076-a
  • [Letter] A Safety Net for Diabetics
    • Authors: Jonathan C. Javitt
      Abstract: Author: Jonathan C. Javitt
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1076-b
  • [Letter] Supporting Mavericks
    • Authors: Peter Andrews
      Abstract: Author: Peter Andrews
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1077-a
  • [Correction] Corrections and Clarifications
    • PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1077-b
  • [Book Review] Culturing the Forest
    • Authors: Tobias Plieninger
      Abstract: Examining the widespread resurgence of woodlands, the authors build a multifaceted view of forests as social-ecological systems. Author: Tobias Plieninger
      Keywords: Environment
      PubDate: 2014-03-07
      DOI: 10.1126/science.1250655
  • [Book Review] More Common Than We Think
    • Authors: Donald Turcotte
      Abstract: Kieffer offers an engaging, fast-moving introduction to natural disasters caused by Earth's ongoing geological processes. Author: Donald Turcotte
      Keywords: Natural Disasters
      PubDate: 2014-03-07
      DOI: 10.1126/science.1250654
  • [Books et al.] Books Received
    • Abstract: A listing of books received at Science during the week ending 28 February 2014.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1079-b
  • [Policy Forum] Why Should We Care About Temporary Waterways?
    • Authors: V. Acuña
      Abstract: Intermittently flowing streams and rivers should be recognized, afforded protection, and better managed.
      Authors : V. Acuña, T. Datry, J. Marshall, D. Barceló, C. N. Dahm, A. Ginebreda, G. McGregor, S. Sabater, K. Tockner, M. A. Palmer
      Keywords: Conservation
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246666
  • [Perspective] The Secret Garden—Epigenetic Alleles Underlie Complex
    • Authors: Robert J. Schmitz
      Abstract: In the plant Arabidopsis thaliana, epigenetic variation, like genetic change, is potentially a substrate for Darwinian evolution. [Also see Report by Cortijo et al.] Author: Robert J. Schmitz
      Keywords: Genetics
      PubDate: 2014-03-07
      DOI: 10.1126/science.1251864
  • [Perspective] CO Meets CO, One at a Time
    • Authors: Miquel Salmeron
      Abstract: An atomic force microscope is used to measure the molecular forces between two carbon monoxide (CO) molecules. [Also see Report by Weymouth et al.] Author: Miquel Salmeron
      Keywords: Chemistry
      PubDate: 2014-03-07
      DOI: 10.1126/science.1251251
  • [Perspective] Water Loss from the Great Lakes
    • Authors: Andrew D. Gronewold
      Abstract: Knowledge of the drivers behind recent record low water levels in the North American Great Lakes can help water resource management planning.
      Authors : Andrew D. Gronewold, Craig A. Stow
      Keywords: Environment
      PubDate: 2014-03-07
      DOI: 10.1126/science.1249978
  • [Perspective] Feedback of the Magnetosphere
    • Authors: Joseph E. Borovsky
      Abstract: A dense cold plasma from Earth's ionosphere can counter strong solar wind. [Also see Report by Walsh et al.] Author: Joseph E. Borovsky
      Keywords: Geophysics
      PubDate: 2014-03-07
      DOI: 10.1126/science.1250590
  • [Perspective] A Genomic Road Map for Complex Human Disease
    • Authors: Peter K. Gregersen
      Abstract: Consideration of cell type- and disease-associated environmental conditions is critical to connecting specific genetic variants to immune disorders. [Also see Research Articles by Fairfax et al. and Lee et al.] Author: Peter K. Gregersen
      Keywords: Genetics
      PubDate: 2014-03-07
      DOI: 10.1126/science.1251426
  • [Perspective] Combating Evolution to Fight Disease
    • Authors: Susan M. Rosenberg
      Abstract: Molecular mechanisms that generate biological diversity are rewriting ideas about how evolution proceeds, with implications for treating disease.
      Authors : Susan M. Rosenberg, Christine Queitsch
      Keywords: Medicine
      PubDate: 2014-03-07
      DOI: 10.1126/science.1247472
  • [Introduction to Special Issue] Going from Strength to Strength
    • Authors: Robert Coontz
      Authors : Robert Coontz, Julia Fahrenkamp-Uppenbrink, Marc Lavine, Valda Vinson
      Keywords: Introduction
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1091
  • [Special Issue News] Dazzling History
    • Authors: Thomas Sumner
      Abstract: Over the past century, x-ray crystallography has transformed scientists' understanding of the structure and behavior of materials. Author: Thomas Sumner
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1092
  • [Special Issue News] Gently Does It
    • Authors: Robert F. Service
      Abstract: A technique for crystallizing fragile biomolecules without disrupting them is helping researchers probe the structures of some of the body's most important but elusive proteins: those that usher other chemicals through the cell membrane. Author: Robert F. Service
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1094
  • [Special Issue Review] Cutting-Edge Techniques Used for the Structural
           Investigation of Single Crystals
    • Authors: Judith A. K. Howard
      Abstract: X-ray crystallography has become the leading technique for studying the structure of matter at the atomic and molecular level. Today it underpins all sciences and is widely applied in industry. It is essential in the development of new materials. The technique is very powerful, and the range of materials that can be studied expands as new technologies evolve and are applied in innovative ways to structure solution. It is now possible to record vast amounts of diffraction data in seconds electronically, whereas it took days and months by photographic methods 30 to 40 years ago. Single crystals can be created in various ways; they can be produced from compounds that are liquids or gases at room temperature, and complete molecular structures can be presented within minutes. This short review presents recent developments that are appropriate to the single-crystal x-ray studies of chemical and materials sciences.
      Authors : Judith A. K. Howard, Michael R. Probert
      PubDate: 2014-03-07
      DOI: 10.1126/science.1247252
  • [Special Issue Review] Developments in X-ray Crystallographic Structure
           Determination of Biological Macromolecules
    • Authors: Elspeth F. Garman
      Abstract: The three-dimensional structures of large biomolecules important in the function and mechanistic pathways of all living systems and viruses can be determined by x-ray diffraction from crystals of these molecules and their complexes. This area of crystallography is continually expanding and evolving, and the introduction of new methods that use the latest technology is allowing the elucidation of ever larger and more complex biological systems, which are now becoming tractable to structure solution. This review looks back at what has been achieved and forward at how current and future developments may allow technical challenges to be overcome. Author: Elspeth F. Garman
      PubDate: 2014-03-07
      DOI: 10.1126/science.1247829
  • [Special Issue Review] Femtosecond Crystallography with Ultrabright
           Electrons and X-rays: Capturing Chemistry in Action
    • Authors: R. J. Dwayne Miller
      Abstract: With the recent advances in ultrabright electron and x-ray sources, it is now possible to extend crystallography to the femtosecond time domain to literally light up atomic motions involved in the primary processes governing structural transitions. This review chronicles the development of brighter and brighter electron and x-ray sources that have enabled atomic resolution to structural dynamics for increasingly complex systems. The primary focus is on achieving sufficient brightness using pump-probe protocols to resolve the far-from-equilibrium motions directing chemical processes that in general lead to irreversible changes in samples. Given the central importance of structural transitions to conceptualizing chemistry, this emerging field has the potential to significantly improve our understanding of chemistry and its connection to driving biological processes. Author: R. J. Dwayne Miller
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248488
  • [Research Article] Dynamic Reorganization of River Basins
    • Authors: Sean D. Willett
      Abstract: A proxy for river elevation demonstrates the degree to which river networks reorganize and equilibrate.
      Authors : Sean D. Willett, Scott W. McCoy, J. Taylor Perron, Liran Goren, Chia-Yu Chen
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248765
  • [Research Article] Innate Immune Activity Conditions the Effect of
           Regulatory Variants upon Monocyte Gene Expression
    • Authors: Benjamin P. Fairfax
      Abstract: Analysis of the transcriptional responses during induced innate immune activity in primary human monocytes is explained. [Also see Perspective by Gregersen]
      Authors : Benjamin P. Fairfax, Peter Humburg, Seiko Makino, Vivek Naranbhai, Daniel Wong, Evelyn Lau, Luke Jostins, Katharine Plant, Robert Andrews, Chris McGee, Julian C. Knight
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246949
  • [Research Article] Common Genetic Variants Modulate Pathogen-Sensing
           Responses in Human Dendritic Cells
    • Authors: Mark N. Lee
      Abstract: Mapping human host-pathogen gene-by-environment interactions identifies pathogen-specific loci. [Also see Perspective by Gregersen]
      Authors : Mark N. Lee, Chun Ye, Alexandra-Chloé Villani, Towfique Raj, Weibo Li, Thomas M. Eisenhaure, Selina H. Imboywa, Portia I. Chipendo, F. Ann Ran, Kamil Slowikowski, Lucas D. Ward, Khadir Raddassi, Cristin McCabe, Michelle H. Lee, Irene Y. Frohlich, David A. Hafler, Manolis Kellis, Soumya Raychaudhuri, Feng Zhang, Barbara E. Stranger, Christophe O. Benoist, Philip L. De Jager, Aviv Regev, Nir Hacohen
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246980
  • [Report] Quantifying Molecular Stiffness and Interaction with Lateral
           Force Microscopy
    • Authors: Alfred John Weymouth
      Abstract: Lateral force microscopy reveals the torsional spring constant of a carbon monoxide molecule at the end of an atomic force microscope tip. [Also see Perspective by Salmeron]
      Authors : Alfred John Weymouth, Thomas Hofmann, Franz J. Giessibl
      PubDate: 2014-03-07
      DOI: 10.1126/science.1249502
  • [Report] Simultaneous Ground- and Space-Based Observations of the
           Plasmaspheric Plume and Reconnection
    • Authors: B. M. Walsh
      Abstract: Ground-based and satellite observations show that a plume extends all the way to the magnetopause and can persist for hours. [Also see Perspective by Borovsky]
      Authors : B. M. Walsh, J. C. Foster, P. J. Erickson, D. G. Sibeck
      PubDate: 2014-03-07
      DOI: 10.1126/science.1247212
  • [Report] Tunable Phonon Polaritons in Atomically Thin van der Waals
           Crystals of Boron Nitride
    • Authors: S. Dai
      Abstract: Infrared nanoimaging is used to detect a type of surface collective mode in a representative van der Waals crystal.
      Authors : S. Dai, Z. Fei, Q. Ma, A. S. Rodin, M. Wagner, A. S. McLeod, M. K. Liu, W. Gannett, W. Regan, K. Watanabe, T. Taniguchi, M. Thiemens, G. Dominguez, A. H. Castro Neto, A. Zettl, F. Keilmann, P. Jarillo-Herrero, M. M. Fogler, D. N. Basov
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246833
  • [Report] Rapid Reductions in North Atlantic Deep Water During the Peak of
           the Last Interglacial Period
    • Authors: Eirik Vinje Galaasen
      Abstract: Deep ocean circulation was less stable during the last interglacial periods than previously supposed.
      Authors : Eirik Vinje Galaasen, Ulysses S. Ninnemann, Nil Irvalı, Helga (Kikki) F. Kleiven, Yair Rosenthal, Catherine Kissel, David A. Hodell
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248667
  • [Report] Structural Basis for Heavy Metal Detoxification by an Atm1-Type
           ABC Exporter
    • Authors: Jonas Y. Lee
      Abstract: Structural and functional studies of ABC exporters provide insight into how glutathione derivatives are translocated.
      Authors : Jonas Y. Lee, Janet G. Yang, Daniel Zhitnitsky, Oded Lewinson, Douglas C. Rees
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246489
  • [Report] Crystal Structures of Nucleotide-Free and Glutathione-Bound
           Mitochondrial ABC Transporter Atm1
    • Authors: Vasundara Srinivasan
      Abstract: Structural and functional studies of ABC exporters provide insight into how glutathione derivatives are translocated.
      Authors : Vasundara Srinivasan, Antonio J. Pierik, Roland Lill
      PubDate: 2014-03-07
      DOI: 10.1126/science.1246729
  • [Report] Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis
           of Carbapenem Antibiotics
    • Authors: Wei-chen Chang
      Abstract: Crystallography and spectroscopy detail a key mechanistic step in the microbial biosynthesis of an important antibiotic class.
      Authors : Wei-chen Chang, Yisong Guo, Chen Wang, Susan E. Butch, Amy C. Rosenzweig, Amie K. Boal, Carsten Krebs, J. Martin Bollinger
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248000
  • [Report] Mapping the Epigenetic Basis of Complex Traits
    • Authors: Sandra Cortijo
      Abstract: Genetic mapping reveals epigenetic changes associated with flowering time and root length. [Also see Perspective by Schmitz]
      Authors : Sandra Cortijo, René Wardenaar, Maria Colomé-Tatché, Arthur Gilly, Mathilde Etcheverry, Karine Labadie, Erwann Caillieux, Fréderic Hospital, Jean-Marc Aury, Patrick Wincker, François Roudier, Ritsert C. Jansen, Vincent Colot, Frank Johannes
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248127
  • [Report] A Single Gene Affects Both Ecological Divergence and Mate Choice
           in Drosophila
    • Authors: Henry Chung
      Abstract: A methyl-branched cuticular hydrocarbon affects both desiccation resistance and mate choice in related Drosophila species.
      Authors : Henry Chung, David W. Loehlin, Héloïse D. Dufour, Kathy Vaccarro, Jocelyn G. Millar, Sean B. Carroll
      PubDate: 2014-03-07
      DOI: 10.1126/science.1249998
  • [Report] Long-Acting Integrase Inhibitor Protects Macaques from
           Intrarectal Simian/Human Immunodeficiency Virus
    • Authors: Chasity D. Andrews
      Abstract: Prolonged protection from repeated SHIV challenges is demonstrated in macaques.
      Authors : Chasity D. Andrews, William R. Spreen, Hiroshi Mohri, Lee Moss, Susan Ford, Agegnehu Gettie, Kasi Russell-Lodrigue, Rudolf P. Bohm, Cecilia Cheng-Mayer, Zhi Hong, Martin Markowitz, David D. Ho
      PubDate: 2014-03-07
      DOI: 10.1126/science.1248707
  • [Report] Altitudinal Changes in Malaria Incidence in Highlands of Ethiopia
           and Colombia
    • Authors: A. S. Siraj
      Abstract: Warmer years promote malaria cases at higher altitudes.
      Authors : A. S. Siraj, M. Santos-Vega, M. J. Bouma, D. Yadeta, D. Ruiz Carrascal, M. Pascual
      PubDate: 2014-03-07
      DOI: 10.1126/science.1244325
  • [New Products] New Products
    • Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1159-a
  • [Podcast] Science Podcast: 7 March Show
    • Abstract: Listen to stories on 100 years of crystallography, firming up the link between climate change and malaria, and more.
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1159-b
  • [Business Office Feature] The Sequencing Continuum for Clinical Research:
           From Sanger to Next Gen
    • Authors: Miguel E. Quiones-Mateu
      Abstract: Miguel E. Quiones-Mateu
      Keywords: Science Webinar Series
      PubDate: 2014-03-07
      DOI: 10.1126/science.343.6175.1159-c
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