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Journal Cover Science
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     ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
     Published by American Association for the Advancement of Science (AAAS) Homepage  [3 journals]   [SJR: 10.618]   [H-I: 739]
  • [Perspective] Managing patterns and proportions over time
    • Authors: Olivier Pourquie
      Abstract: Tissue patterning is specified relative to growth through differences between cell proliferation and the differentiation rates [Also see Research Article by Kicheva et al.] Author: Olivier Pourquie
      Keywords: Developmental Biology
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260025
  • [Perspective] Perovskites take lead in solar hydrogen race
    • Authors: Thomas Hamann
      Abstract: Earth-abundant materials show promise for solar hydrogen production [Also see Report by Luo et al.] Author: Thomas Hamann
      Keywords: Chemistry
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260051
  • [Perspective] A dynamic tool for nitrogen reduction
    • Authors: Martin Högbom
      Abstract: Carbon monoxide reveals new possibilities for substrate binding in nitrogenase [Also see Report by Spatzal et al.] Author: Martin Högbom
      Keywords: Nitrogenase Mechanism
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260021
  • [Book Review] Feeling your pain
    • Authors: Warwick Anderson
      Abstract: Author: Warwick Anderson
      Keywords: Science and Policy
      PubDate: 2014-09-26
      DOI: 10.1126/science.1258768
  • [Books et al.] Books Received
    • Abstract: A listing of books received at Science during the week ending 19 September 2014.
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1569-b
  • [Letter] Brazil's new laws bug collectors
    • Authors: Danilo Bandini Ribeiro
      Authors : Danilo Bandini Ribeiro, André Victor Lucci Freitas
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1571-a
  • [Letter] Parenting: Section deserves a scolding
    • Authors: Jean Mercer
      Abstract: Author: Jean Mercer
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1571-b
  • [Letter] Parenting: Roots of the sweet tooth
    • Authors: André Krumel Portella
      Authors : André Krumel Portella, Patrícia Pelufo Silveira
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1571-c
  • [Association Affairs] AAAS news and notes
    • Abstract: A monthly roundup of recent news and projects of Science's publisher, the American Association for the Advancement of Science.
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1573
  • [Feature] NOνA's shining moment
    • Authors: Adrian Cho
      Abstract: Despite years of delay, Fermilab's massive new experiment has a chance to take the next big step in neutrino physics. Author: Adrian Cho
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1555
  • [Perspective] Whose conservation?
    • Authors: Georgina M. Mace
      Abstract: Changes in the perception and goals of nature conservation require a solid scientific basis Author: Georgina M. Mace
      Keywords: Ecology
      PubDate: 2014-09-26
      DOI: 10.1126/science.1254704
  • [Perspective] Autoimmunity by haploinsufficiency
    • Authors: Frédéric Rieux-Laucat
      Abstract: Partial deficiency in the protein CTLA4 underlies severe autoimmune disease with incomplete penetrance [Also see Report by Kuehn et al.]
      Authors : Frédéric Rieux-Laucat, Jean-Laurent Casanova
      Keywords: Immunology
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260791
  • [Policy Forum] Implementing Pasteur's vision for rabies elimination
    • Authors: Felix Lankester
      Abstract: Human and veterinary health systems must be better integrated if rabies is to be controlled
      Authors : Felix Lankester, Katie Hampson, Tiziana Lembo, Guy Palmer, Louise Taylor, Sarah Cleaveland
      Keywords: Infectious Disease
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256306
  • [Perspective] Water's place in Au catalysis
    • Authors: Gregory M. Mullen
      Abstract: Water plays a key role in gold-catalyzed CO oxidation [Also see Report by Saavedra et al.]
      Authors : Gregory M. Mullen, C. Buddie Mullins
      Keywords: Chemistry
      PubDate: 2014-09-26
      DOI: 10.1126/science.1259527
  • [Feature] On the edge
    • Authors: Gabriel Popkin
      Abstract: Ecologist Marten Scheffer became a leader in the science of tipping points by studying lakes. Now he's making waves in many other fields. Author: Gabriel Popkin
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1552
  • [In Brief] This week's section
    • Abstract: A roundup of weekly science policy and related news.
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1544
  • [In Depth] Evidence for cosmic inflation wanes
    • Authors: Adrian Cho
      Abstract: The biggest result in cosmology in a decade fades into dust. Author: Adrian Cho
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1547
  • [In Depth] Red wolves in the crosshairs
    • Authors: Erik Stokstad
      Abstract: U.S. agency ponders future of innovative reintroduction as animal deaths and controversy mount. Author: Erik Stokstad
      Keywords: Endangered Species
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1548
  • [In Depth] Testing new Ebola tests
    • Authors: Gretchen Vogel
      Abstract: Identifying infections more quickly and easily could help slow the epidemic. Author: Gretchen Vogel
      Keywords: Infectious Diseases
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1549
  • [In Depth] Metabolic shift may train immune cells
    • Authors: Elizabeth Pennisi
      Abstract: BLUEPRINT project studies epigenetics of various blood cells. Author: Elizabeth Pennisi
      Keywords: Immunology
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1550
  • [Editorial] The drought you can't see
    • Authors: Marcia McNutt
      Abstract: The Western Hemisphere is experiencing a drought of crisis proportions. In Central America, crops are failing, millions are in danger of starvation, and if the drought doesn't break soon, even vessels transiting the Panama Canal will need to lighten their loads, which will increase prices for goods transported globally. In the western United States, the drought-stricken region spans a vast area responsible for much of the nation's fruits, vegetables, and beef. As the drought's grip has tightened, water users have turned to tapping groundwater aquifers to make up the deficit for people, crops, livestock, and industry. But even when the rain does return, regreening the landscape and filling again the streams, lakes, and reservoirs, those aquifers will remain severely depleted. It is this underground drought we can't see that is enduring, worrisome, and in need of attention. Author: Marcia McNutt
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260795
  • This Week in Science
    • Authors: Pamela J. Hines
      Abstract: A complex network makes simple pores Crustal rebound from water drawdown Mysterious dinosaur a swimmer? Easier oxidation over gold with added water Beware of T cells that don't know how to stop Closing the loop on neuroprosthetic control Hot electron plasma moves in from Io Preventing vascular scarring after surgery Differentiation rates regulate pool sizes Carbon chains branch out on space dust Nature or nurture for solar system ices? A BLUEPRINT of immune cell development Making nitrogen available for biosynthesis The power of a pair of perovskites Breaking down a Criegee intermediate An early assemblage of obsidian artifacts How plant species diversity is shaped Animal behavior follows rewards Views of nature, views of conservation
      Keywords: Plant Development
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1574-a
  • [Report] Ligand binding to the FeMo-cofactor: Structures of CO-bound and
           reactivated nitrogenase
    • Authors: Thomas Spatzal
      Abstract: The structure of an inhibitor bound to nitrogenase reveals rearrangements in the active-site metallocluster. [Also see Perspective by Hognom]
      Authors : Thomas Spatzal, Kathryn A. Perez, Oliver Einsle, James B. Howard, Douglas C. Rees
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256679
  • [Report] Immune dysregulation in human subjects with heterozygous germline
           mutations in CTLA4
    • Authors: Hye Sun Kuehn
      Abstract: A mutation in a single copy of the CTLA4 gene in people is associated with immune dysfunction. [Also see Perspective by Rieux-Laucat and Casanova]
      Authors : Hye Sun Kuehn, Weiming Ouyang, Bernice Lo, Elissa K. Deenick, Julie E. Niemela, Danielle T. Avery, Jean-Nicolas Schickel, Dat Q. Tran, Jennifer Stoddard, Yu Zhang, David M. Frucht, Bogdan Dumitriu, Phillip Scheinberg, Les R. Folio, Cathleen A. Frein, Susan Price, Christopher Koh, Theo Heller, Christine M. Seroogy, Anna Huttenlocher, V. Koneti Rao, Helen C. Su, David Kleiner, Luigi D. Notarangelo, Yajesh Rampertaap, Kenneth N. Olivier, Joshua McElwee, Jason Hughes, Stefania Pittaluga, Joao B. Oliveira, Eric Meffre, Thomas A. Fleisher, Steven M. Holland, Michael J. Lenardo, Stuart G. Tangye, Gulbu Uzel
      PubDate: 2014-09-26
      DOI: 10.1126/science.1255904
  • [Association Affairs] Gordon Research Conferences
    • Abstract: This issue of Science includes the program of the 2015 AAAS Annual Meeting. 2015 “Session I” Meetings will be held between January and May in California and Texas in the United States, and internationally in Lucca (Barga), Italy and Hong Kong, China. A PDF of the program as it appears in this issue is available here; for more information on the meeting (including registration forms and information on accommodations), please visit
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1628
  • [New Products] New Products
    • Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1638-a
  • [Podcast] Science Podcast: 26 September Show
    • Abstract: On this week's show: Tracing the roots of an ancient stone-age technology and a daily news round up with David Grimm.
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1638-b
  • [Business Office Feature] Culturing human cells: Optimizing growth
           conditions for immunotherapy
    • Authors: Laurence J. N. Cooper
      Abstract: Laurence J. N. Cooper
      Keywords: Science Webinar Series
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1638-c
  • [Business Office Feature] CRISPR-Cas9: Engineering a revolution in gene
    • Abstract: The CRISPR-Cas9 system is revolutionizing genomic engineering and equipping scientists with the ability to precisely modify the DNA of essentially any organism. Just how powerful is this technique? The ability for precision genome engineering comes with the potential to enhance food production, medicinal discoveries, and energy solutions, to name a few. In this booklet, we invite you to explore a selection of Science articles that highlight how this technique has grown into one of the most powerful genomic engineering tools to date. CRISPR-Cas9 (PDF, 14.6 MB)CRISPR-Cas9 (PDF, low resolution version, 3.16 MB)Read the e-bookletThis booklet brought to you by the Science/AAAS Custom Publishing Office.
      DOI : 10.1126/science.opms.sb0002
      PubDate: 2014-09-26
  • [Working Life] The borders I crossed
    • Authors: Rodica Stan
      Abstract: Author: Rodica Stan
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1650
  • [Report] The critical role of water at the gold-titania interface in
           catalytic CO oxidation
    • Authors: Johnny Saavedra
      Abstract: Adsorbed water enables proton-transfer steps that lower the activation barrier for carbon monoxide oxidation. [Also see Perspective by Mullen and Mullins]
      Authors : Johnny Saavedra, Hieu A. Doan, Christopher J. Pursell, Lars C. Grabow, Bert D. Chandler
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256018
  • [Report] Environmental filtering explains variation in plant diversity
           along resource gradients
    • Authors: Etienne Laliberté
      Abstract: A >2-million-year soil chronosequence reveals how the environment can regulate species plant diversity.
      Authors : Etienne Laliberté, Graham Zemunik, Benjamin L. Turner
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256330
  • [Report] Direct roles of SPEECHLESS in the specification of stomatal
           self-renewing cells
    • Authors: On Sun Lau
      Abstract: The molecular pathways that regulate an essential adult stem cell lineage in plant stomata are dissected.
      Authors : On Sun Lau, Kelli A. Davies, Jessica Chang, Jessika Adrian, Matthew H. Rowe, Catherine E. Ballenger, Dominique C. Bergmann
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256888
  • [Report] Early Levallois technology and the Lower to Middle Paleolithic
           transition in the Southern Caucasus
    • Authors: D. S. Adler
      Abstract: An assemblage of obsidian artifacts suggests independent origins of stone knapping in different hominin populations.
      Authors : D. S. Adler, K. N. Wilkinson, S. Blockley, D. F. Mark, R. Pinhasi, B. A. Schmidt-Magee, S. Nahapetyan, C. Mallol, F. Berna, P. J. Glauberman, Y. Raczynski-Henk, N. Wales, E. Frahm, O. Jöris, A. MacLeod, V. C. Smith, V. L. Cullen, B. Gasparian
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256484
  • [Report] Semiaquatic adaptations in a giant predatory dinosaur
    • Authors: Nizar Ibrahim
      Abstract: New fossils of the sail-finned predatory dinosaur Spinosaurus reveal that it lived in and near water.
      Authors : Nizar Ibrahim, Paul C. Sereno, Cristiano Dal Sasso, Simone Maganuco, Matteo Fabbri, David M. Martill, Samir Zouhri, Nathan Myhrvold, Dawid A. Iurino
      PubDate: 2014-09-26
      DOI: 10.1126/science.1258750
  • [Report] A critical time window for dopamine actions on the structural
           plasticity of dendritic spines
    • Authors: Sho Yagishita
      Abstract: Dopamine promotes spine structural plasticity during a narrow time window in mouse neuron distal dendrites.
      Authors : Sho Yagishita, Akiko Hayashi-Takagi, Graham C.R. Ellis-Davies, Hidetoshi Urakubo, Shin Ishii, Haruo Kasai
      PubDate: 2014-09-26
      DOI: 10.1126/science.1255514
  • [Report] Detection of a branched alkyl molecule in the interstellar
           medium: iso-propyl cyanide
    • Authors: Arnaud Belloche
      Abstract: Millimeter-wave emission is detected from branched carbon-chain molecules that may form on interstellar dust-grain surfaces.
      Authors : Arnaud Belloche, Robin T. Garrod, Holger S. P. Müller, Karl M. Menten
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256678
  • [Report] Ongoing drought-induced uplift in the western United States
    • Authors: Adrian Antal Borsa
      Abstract: GPS measurements of crustal rebound in the western U.S. quantify drought-induced regional water depletion.
      Authors : Adrian Antal Borsa, Duncan Carr Agnew, Daniel R. Cayan
      Keywords: REMOTE HYDROLOGY
      PubDate: 2014-09-26
      DOI: 10.1126/science.1260279
  • [Report] The ancient heritage of water ice in the solar system
    • Authors: L. Ilsedore Cleeves
      Abstract: A model tracing the path of deuterium in the solar system shows that its abundance hails from the parent interstellar medium.
      Authors : L. Ilsedore Cleeves, Edwin A. Bergin, Conel M. O’D. Alexander, Fujun Du, Dawn Graninger, Karin I. Öberg, Tim J. Harries
      PubDate: 2014-09-26
      DOI: 10.1126/science.1258055
  • [Report] Water photolysis at 12.3% efficiency via perovskite photovoltaics
           and Earth-abundant catalysts
    • Authors: Jingshan Luo
      Abstract: A pair of perovskite solar cells can power efficient hydrogen generation from water. [Also see Perspective by Hamann]
      Authors : Jingshan Luo, Jeong-Hyeok Im, Matthew T. Mayer, Marcel Schreier, Mohammad Khaja Nazeeruddin, Nam-Gyu Park, S. David Tilley, Hong Jin Fan, Michael Grätzel
      PubDate: 2014-09-26
      DOI: 10.1126/science.1258307
  • [Report] Infrared-driven unimolecular reaction of CH3CHOO Criegee
           intermediates to OH radical products
    • Authors: Fang Liu
      Abstract: Spectroscopy in the laboratory elucidates key steps in ozone’s atmospheric reaction with unsaturated hydrocarbons.
      Authors : Fang Liu, Joseph M. Beames, Andrew S. Petit, Anne B. McCoy, Marsha I. Lester
      PubDate: 2014-09-26
      DOI: 10.1126/science.1257158
  • [Research Article] Transcriptional diversity during lineage commitment of
           human blood progenitors
    • Authors: Lu Chen
      Abstract: RNA sequencing identifies how different cell fate decisions are made during blood cell differentiation.
      Authors : Lu Chen, Myrto Kostadima, Joost H. A. Martens, Giovanni Canu, Sara P. Garcia, Ernest Turro, Kate Downes, Iain C. Macaulay, Ewa Bielczyk-Maczynska, Sophia Coe, Samantha Farrow, Pawan Poudel, Frances Burden, Sjoert B. G. Jansen, William J. Astle, Antony Attwood, Tadbir Bariana, Bernard de Bono, Alessandra Breschi, John C. Chambers, , Fizzah A. Choudry, Laura Clarke, Paul Coupland, Martijn van der Ent, Wendy N. Erber, Joop H. Jansen, Rémi Favier, Matthew E. Fenech, Nicola Foad, Kathleen Freson, Chris van Geet, Keith Gomez, Roderic Guigo, Daniel Hampshire, Anne M. Kelly, Hindrik H. D. Kerstens, Jaspal S. Kooner, Michael Laffan, Claire Lentaigne, Charlotte Labalette, Tiphaine Martin, Stuart Meacham, Andrew Mumford, Sylvia Nürnberg, Emilio Palumbo, Bert A. van der Reijden, David Richardson, Stephen J. Sammut, Greg Slodkowicz, Asif U. Tamuri, Louella Vasquez, Katrin Voss, Stephen Watt, Sarah Westbury, Paul Flicek, Remco Loos, Nick Goldman, Paul Bertone, Randy J. Read, Sylvia Richardson, Ana Cvejic, Nicole Soranzo, Willem H. Ouwehand, Hendrik G. Stunnenberg, Mattia Frontini, Augusto Rendon
      PubDate: 2014-09-26
      DOI: 10.1126/science.1251033
  • [Report] Evidence for global electron transportation into the jovian inner
    • Authors: K. Yoshioka
      Abstract: Near-Earth satellite measurements in the extreme ultraviolet examine a charged torus produced by volcanoes on Jupiter’s moon Io.
      Authors : K. Yoshioka, G. Murakami, A. Yamazaki, F. Tsuchiya, T. Kimura, M. Kagitani, T. Sakanoi, K. Uemizu, Y. Kasaba, I. Yoshikawa, M. Fujimoto
      PubDate: 2014-09-26
      DOI: 10.1126/science.1256259
  • Editors' Choice
    • Authors: Peter Stern
      Abstract: Timing counts for whisker development Animal behavior follows dopamine rewards Bring out your dead — hungry receptors await An Arabian wintertime bloom on the rise Hate and violence spread through the air Social complexity creates brainy parrots Teaching tolerance stops the bleeding Constructing a maze full of phosphines
      Keywords: Neuroscience
      PubDate: 2014-09-26
      DOI: 10.1126/science.345.6204.1575-a
  • [Research Article] Coordination of progenitor specification and growth in
           mouse and chick spinal cord
    • Authors: Anna Kicheva
      Abstract: Embryonic chick and mouse reveal how neural tube differentiation takes on new strategies as development progresses. [Also see Perspective by Pourquie]
      Authors : Anna Kicheva, Tobias Bollenbach, Ana Ribeiro, Helena Pérez Valle, Robin Lovell-Badge, Vasso Episkopou, James Briscoe
      PubDate: 2014-09-26
      DOI: 10.1126/science.1254927
  • [Research Article] Epigenetic programming of monocyte-to-macrophage
           differentiation and trained innate immunity
    • Authors: Sadia Saeed
      Abstract: Genome-wide approaches analyze human monocyte differentiation in vitro into functional macrophages.
      Authors : Sadia Saeed, Jessica Quintin, Hindrik H. D. Kerstens, Nagesha A. Rao, Ali Aghajanirefah, Filomena Matarese, Shih-Chin Cheng, Jacqueline Ratter, Kim Berentsen, Martijn A. van der Ent, Nilofar Sharifi, Eva M. Janssen-Megens, Menno Ter Huurne, Amit Mandoli, Tom van Schaik, Aylwin Ng, Frances Burden, Kate Downes, Mattia Frontini, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Willem H. Ouwehand, Jos W. M. van der Meer, Leo A. B. Joosten, Cisca Wijmenga, Joost H. A. Martens, Ramnik J. Xavier, Colin Logie, Mihai G. Netea, Hendrik G. Stunnenberg
      PubDate: 2014-09-26
      DOI: 10.1126/science.1251086
  • [Research Article] mTOR- and HIF-1α–mediated aerobic glycolysis
           as metabolic basis for trained immunity
    • Authors: Shih-Chin Cheng
      Abstract: Epigenetic profiling identifies the cellular metabolic substrate of innate immune memory.
      Authors : Shih-Chin Cheng, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Vinod Kumar, Evangelos J. Giamarellos-Bourboulis, Joost H. A. Martens, Nagesha Appukudige Rao, Ali Aghajanirefah, Ganesh R. Manjeri, Yang Li, Daniela C. Ifrim, Rob J. W. Arts, Brian M. J. W. van der Meer, Peter M. T. Deen, Colin Logie, Luke A. O’Neill, Peter Willems, Frank L. van de Veerdonk, Jos W. M. van der Meer, Aylwin Ng, Leo A. B. Joosten, Cisca Wijmenga, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea
      PubDate: 2014-09-26
      DOI: 10.1126/science.1250684
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