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Journal Cover Science
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     ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
     Published by American Association for the Advancement of Science (AAAS) Homepage  [3 journals]   [SJR: 10.618]   [H-I: 739]
  • [Introduction to Special Issue] A legacy that transcends genes
    • Authors: Beverly A. Purnell
      Abstract: Author: Beverly A. Purnell
      Keywords: Parenting
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.742
  • [Special Issue News] Unsettled questions trail IVF's success
    • Authors: Kelly Servick
      Abstract: Researchers are still struggling to understand the potential long-term effects of assisted reproduction. Author: Kelly Servick
      Keywords: Parenting
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.744
  • [Special Issue News] Nature's first functional food
    • Authors: Trisha Gura
      Abstract: Breast milk feeds helpful microbes, fights harmful ones, provides immunity, and jump-starts a newborn's life. Author: Trisha Gura
      Keywords: Parenting
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.747
  • [Special Issue News] The taste of things to come
    • Authors: Emily Underwood
      Abstract: Early postnatal, and even prenatal, experiences shape culinary tastes. Author: Emily Underwood
      Keywords: Parenting
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.750
  • [Feature] Mother of all lodes
    • Authors: Richard Stone
      Abstract: The United States is putting scientific boots on the ground in Afghanistan to assess its mineral riches. Author: Richard Stone
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.725
  • [Policy Forum] Technology's limited role in resolving debates over digital
    • Authors: Herbert Lin
      Abstract: Teasing apart technical issues from social and political issues Author: Herbert Lin
      Keywords: Information Technology
      PubDate: 2014-08-15
      DOI: 10.1126/science.1251485
  • [Perspective] Letting go of mucus
    • Authors: Jeffrey J. Wine
      Abstract: Defective release of mucus from airway glands is present at birth in cystic fibrosis [Also see Report by Hoegger et al.] Author: Jeffrey J. Wine
      Keywords: Medicine
      PubDate: 2014-08-15
      DOI: 10.1126/science.1258493
  • [Perspective] Self-assembled RNA nanostructures
    • Authors: Neocles B. Leontis
      Abstract: RNA structures have been designed that self-assemble and are programmable and scalable [Also see Report by Geary et al.]
      Authors : Neocles B. Leontis, Eric Westhof
      Keywords: Chemistry
      PubDate: 2014-08-15
      DOI: 10.1126/science.1257989
  • [Perspective] You are what you eat, but what about your DNA?
    • Authors: Martha Susiarjo
      Abstract: Parental nutrition influences the health of subsequent generations through epigenetic changes in germ cells [Also see Research Article by Radford et al.]
      Authors : Martha Susiarjo, Marisa S. Bartolomei
      Keywords: Epigenetics
      PubDate: 2014-08-15
      DOI: 10.1126/science.1258654
  • [Perspective] Replace contamination, not the pipes
    • Authors: Wolfgang Rauch
      Abstract: Rethinking water treatment additives can have synergistic benefits for urban water management systems [Also see Report by Pikaar et al.]
      Authors : Wolfgang Rauch, Manfred Kleidorfer
      Keywords: Water Treatment
      PubDate: 2014-08-15
      DOI: 10.1126/science.1257988
  • [Perspective] One step closer to O2
    • Authors: R. David Britt
      Abstract: A crucial step in photosynthesis is becoming clearer [Also see Report by Cox et al.]
      Authors : R. David Britt, Paul H. Oyala
      Keywords: Biochemistry
      PubDate: 2014-08-15
      DOI: 10.1126/science.1258008
  • [Book Review] Does springtime feel extra early?
    • Authors: Adam C. Schneider
      Abstract: Author: Adam C. Schneider
      Keywords: Climate Change
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255970
  • [Book Review] Spotlight on the small
    • Authors: Michael Shen
      Abstract: Author: Michael Shen
      Keywords: Microbiology
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255863
  • [Books et al.] Books Received
    • Abstract: A listing of books received at Science during the week ending 08 August 2014.
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.738-b
  • [Letter] HIV cover ill-advised
    • Authors: Rochelle Diamond
      Abstract: Author: Rochelle Diamond
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.739-a
  • [Letter] HIV cover ill-advised—Response
    • Authors: Marcia McNutt
      Abstract: Author: Marcia McNutt
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.739-b
  • [Letter] Climate change: Time to navigate
    • Authors: Greg H. Rau
      Abstract: Author: Greg H. Rau
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.739-c
  • [Letter] Fossil fuels' future
    • Authors: Brendan Mackey
      Authors : Brendan Mackey, David Lindenmayer
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.739-d
  • [Letter] Sharing ideas too soon
    • Authors: Philipe de Souto Barreto
      Abstract: Author: Philipe de Souto Barreto
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.740-a
  • [Letter] Kids' questions transcend conflict
    • Authors: Leïla Perié
      Authors : Leïla Perié, Livio Riboli-Sasco, Claire Ribrault, Ewa Zlotek-Zlotkiewicz
      Keywords: Outside the Tower
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.740-b
  • [Feature] The rising toll
    • Authors: John Bohannon
      Abstract: Newly released data reveal that the war in Afghanistan is becoming more dangerous for civilians. Author: John Bohannon
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.722
  • [Feature] Civilian casualties in Afghanistan
    • Authors: Neil Shortland
      Abstract: The first release of military data on civilian casualties in Afghanistan is now publicly available.
      Authors : Neil Shortland, John Bohannon
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.723
  • [Editorial] Science for lasting peace
    • Authors: Marcia McNutt
      Abstract: Thomas Barnett, a U.S. military geostrategist, has argued that we have leviathan armies that quickly win wars, only to lose the peace. To change that outcome, stability must be established by rebuilding the infrastructure, institutions, and economy of a war-torn nation. An outstanding example of science applied to nation rebuilding is the hyperspectral survey of Afghanistan by the U.S. Geological Survey (USGS) in 2007. This survey quantified 24 world-class mineral deposits (including iron, cobalt, gold, copper, and rare earth elements), positioning Afghanistan to become a major supplier of minerals (see the News story on p. 725), most of which are in demand for the manufacture of cell phones, computers, and renewable energy technologies. Author: Marcia McNutt
      PubDate: 2014-08-15
      DOI: 10.1126/science.1259611
  • [In Brief] This week's section
    • Abstract: A roundup of weekly science policy and related news.
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.716
  • [In Depth] Debate erupts on ‘repurposed’ drugs for Ebola
    • Authors: Martin Enserink
      Abstract: With experimental treatments in short supply, some researchers think existing medicines might work. Author: Martin Enserink
      Keywords: Infectious Diseases
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.718
  • [In Depth] Firing of Los Alamos researcher draws criticism
    • Authors: Jeffrey Mervis
      Abstract: Officials claim paper contained classified information. Author: Jeffrey Mervis
      Keywords: Nuclear Weapons
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.719
  • [In Depth] A boom in boomless seismology
    • Authors: Eric Hand
      Abstract: Densely packed sensors eavesdrop on Earth's hum. Author: Eric Hand
      Keywords: Earth Science
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.720
  • [Errata] Erratum for the Report: “Engineering Modified Bt Toxins to
           Counter Insect Resistance” by M. Soberón, L. Pardo-López,
           I. López, I. Gómez, B. E. Tabashnik, A. Bravo
    • Keywords: ERRATUM
      PubDate: 2014-08-15
      DOI: 10.1126/science.1256132
  • [Report] Sequential histone-modifying activities determine the robustness
           of transdifferentiation
    • Authors: Steven Zuryn
      Abstract: Stepwise modifications to histones ensure efficient and reliable cell conversions in Caenorhabditis elegans.
      Authors : Steven Zuryn, Arnaud Ahier, Manuela Portoso, Esther Redhouse White, Marie-Charlotte Morin, Raphaël Margueron, Sophie Jarriault
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255885
  • [Report] Programmable on-chip DNA compartments as artificial cells
    • Authors: Eyal Karzbrun
      Abstract: DNA-driven biochemical reactions on a fabricated silicon chip recreate protein gradients and oscillations.
      Authors : Eyal Karzbrun, Alexandra M. Tayar, Vincent Noireaux, Roy H. Bar-Ziv
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255550
  • [New Products] New Products
    • Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.833-a
  • [Podcast] Science Podcast: 15 August Show
    • Abstract: On this week's show: Parenting before conception and a news roundup.
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.833-b
  • [Working Life] Outside my comfort zone
    • Authors: Blaise J. Arena
      Abstract: Author: Blaise J. Arena
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.842
  • [Report] Genomic-scale exchange of mRNA between a parasitic plant and its
    • Authors: Gunjune Kim
      Abstract: Strangleweed (Cuscuta pentagona) can exchange large numbers of messenger RNAs with different host plants.
      Authors : Gunjune Kim, Megan L. LeBlanc, Eric K. Wafula, Claude W. dePamphilis, James H. Westwood
      PubDate: 2014-08-15
      DOI: 10.1126/science.1253122
  • [Report] Reducing sewer corrosion through integrated urban water
    • Authors: Ilje Pikaar
      Abstract: Decreasing sulfate added during drinking water treatment can prevent corrosion of sewers caused by wastewater. [Also see Perspective by Rauch and Kleidorfer]
      Authors : Ilje Pikaar, Keshab R. Sharma, Shihu Hu, Wolfgang Gernjak, Jürg Keller, Zhiguo Yuan
      PubDate: 2014-08-15
      DOI: 10.1126/science.1251418
  • [Report] Large environments reveal the statistical structure governing
           hippocampal representations
    • Authors: P. Dylan Rich
      Abstract: Different neurons in the rat hippocampus have different probabilities of being involved in spatial maps.
      Authors : P. Dylan Rich, Hua-Peng Liaw, Albert K. Lee
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255635
  • [Report] Impaired mucus detachment disrupts mucociliary transport in a
           piglet model of cystic fibrosis
    • Authors: Mark J. Hoegger
      Abstract: Lung disease in pigs with cystic fibrosis is caused by aberrant tethering of mucus to the airway glands that produce it. [Also see Perspective by Wine]
      Authors : Mark J. Hoegger, Anthony J. Fischer, James D. McMenimen, Lynda S. Ostedgaard, Alex J. Tucker, Maged A. Awadalla, Thomas O. Moninger, Andrew S. Michalski, Eric A. Hoffman, Joseph Zabner, David A. Stoltz, Michael J. Welsh
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255825
  • [Report] Histone chaperone ASF1A is required for maintenance of
           pluripotency and cellular reprogramming
    • Authors: Elena Gonzalez-Muñoz
      Abstract: Human oocyte reprogramming of the somatic nucleus involves histone chaperone ASF1A.
      Authors : Elena Gonzalez-Muñoz, Yohanna Arboleda-Estudillo, Hasan H. Otu, Jose B. Cibelli
      PubDate: 2014-08-15
      DOI: 10.1126/science.1254745
  • [Report] Pseudo–three-dimensional maps of the diffuse interstellar
           band at 862 nm
    • Authors: Janez Kos
      Abstract: The map of an absorption line with unknown origins correlates well with a map of extinction by interstellar dust.
      Authors : Janez Kos, Tomaž Zwitter, Rosemary Wyse, Olivier Bienaymé, James Binney, Joss Bland-Hawthorn, Kenneth Freeman, Brad K. Gibson, Gerry Gilmore, Eva K. Grebel, Amina Helmi, Georges Kordopatis, Ulisse Munari, Julio Navarro, Quentin Parker, Warren A. Reid, George Seabroke, Sanjib Sharma, Arnaud Siebert, Alessandro Siviero, Matthias Steinmetz, Fred G. Watson, Mary E. K. Williams
      PubDate: 2014-08-15
      DOI: 10.1126/science.1253171
  • [Report] Programmable self-assembly in a thousand-robot swarm
    • Authors: Michael Rubenstein
      Abstract: A thousand-robot swarm can self-assemble into complex shapes through programmed local interactions.
      Authors : Michael Rubenstein, Alejandro Cornejo, Radhika Nagpal
      PubDate: 2014-08-15
      DOI: 10.1126/science.1254295
  • [Report] A single-stranded architecture for cotranscriptional folding of
           RNA nanostructures
    • Authors: Cody Geary
      Abstract: The size of RNA origami nanostructures has been increased with a distinct assembly pattern. [Also see Perspective by Leontis and Westhof]
      Authors : Cody Geary, Paul W. K. Rothemund, Ebbe S. Andersen
      PubDate: 2014-08-15
      DOI: 10.1126/science.1253920
  • [Report] Electronic structure of the oxygen-evolving complex in
           photosystem II prior to O-O bond formation
    • Authors: Nicholas Cox
      Abstract: Electron paramagnetic resonance spectroscopy reveals that photosynthetic production of O2 proceeds from four MnIV ions. [Also see Perspective by Britt and Oyala]
      Authors : Nicholas Cox, Marius Retegan, Frank Neese, Dimitrios A. Pantazis, Alain Boussac, Wolfgang Lubitz
      PubDate: 2014-08-15
      DOI: 10.1126/science.1254910
  • Editors' Choice
    • Authors: Guy Riddihough
      Abstract: Stitching mRNA back together again A sweet decline for the aging fly brain The cost of economic growth Steering an optical signal without wires Coatings keep gunk off nanoparticles How infection rate determines virus spread Looking beneath the drying surface Mercury levels in surface ocean tripled
      Keywords: Unfolded Proteins
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.783-a
  • [Research Article] In utero undernourishment perturbs the adult sperm
           methylome and intergenerational metabolism
    • Authors: Elizabeth J. Radford
      Abstract: Prenatal assaults change DNA methylation and chromatin structure in sperm and affect offspring. [Also see Perspective by Susiarjo and Bartolomei]
      Authors : Elizabeth J. Radford, Mitsuteru Ito, Hui Shi, Jennifer A. Corish, Kazuki Yamazawa, Elvira Isganaitis, Stefanie Seisenberger, Timothy A. Hore, Wolf Reik, Serap Erkek, Antoine H. F. M. Peters, Mary-Elizabeth Patti, Anne C. Ferguson-Smith
      PubDate: 2014-08-15
      DOI: 10.1126/science.1255903
  • [Research Article] Evidence for interstellar origin of seven dust
           particles collected by the Stardust spacecraft
    • Authors: Andrew J. Westphal
      Abstract: Analysis of seven particles captured by aerogel and foil reveals diverse characteristics not conforming to a single model.
      Authors : Andrew J. Westphal, Rhonda M. Stroud, Hans A. Bechtel, Frank E. Brenker, Anna L. Butterworth, George J. Flynn, David R. Frank, Zack Gainsforth, Jon K. Hillier, Frank Postberg, Alexandre S. Simionovici, Veerle J. Sterken, Larry R. Nittler, Carlton Allen, David Anderson, Asna Ansari, Saša Bajt, Ron K. Bastien, Nabil Bassim, John Bridges, Donald E. Brownlee, Mark Burchell, Manfred Burghammer, Hitesh Changela, Peter Cloetens, Andrew M. Davis, Ryan Doll, Christine Floss, Eberhard Grün, Philipp R. Heck, Peter Hoppe, Bruce Hudson, Joachim Huth, Anton Kearsley, Ashley J. King, Barry Lai, Jan Leitner, Laurence Lemelle, Ariel Leonard, Hugues Leroux, Robert Lettieri, William Marchant, Ryan Ogliore, Wei Jia Ong, Mark C. Price, Scott A. Sandford, Juan-Angel Sans Tresseras, Sylvia Schmitz, Tom Schoonjans, Kate Schreiber, Geert Silversmit, Vicente A. Solé, Ralf Srama, Frank Stadermann, Thomas Stephan, Julien Stodolna, Stephen Sutton, Mario Trieloff, Peter Tsou, Tolek Tyliszczak, Bart Vekemans, Laszlo Vincze, Joshua Von Korff, Naomi Wordsworth, Daniel Zevin, Michael E. Zolensky,
      PubDate: 2014-08-15
      DOI: 10.1126/science.1252496
  • [Special Issue Review] The evolution of flexible parenting
    • Authors: Nick J. Royle
      Abstract: Parenting behaviors, such as the provisioning of food by parents to offspring, are known to be highly responsive to changes in environment. However, we currently know little about how such flexibility affects the ways in which parenting is adapted and evolves in response to environmental variation. This is because few studies quantify how individuals vary in their response to changing environments, especially social environments created by other individuals with which parents interact. Social environmental factors differ from nonsocial factors, such as food availability, because parents and offspring both contribute and respond to the social environment they experience. This interdependence leads to the coevolution of flexible behaviors involved in parenting, which could, paradoxically, constrain the ability of individuals to rapidly adapt to changes in their nonsocial environment.
      Authors : Nick J. Royle, Andrew F. Russell, Alastair J. Wilson
      PubDate: 2014-08-15
      DOI: 10.1126/science.1253294
  • This Week in Science
    • Authors: Marc S. Lavine
      Abstract: Large-scale robotic self-assembly Nerve cells displaying extra large spaces Can you spot a speck of space dust? A potential target in a deadly brain cancer Strangleweed shares too much information A breathtaking tale of sticky mucus A Swiss Army knife for treating sepsis The future of RNA origami writ large Sourcing corrosive sewer sulfides The nutritional sins of the mother… Clues to a mystery with RAVE results Setting the stage for release of oxygen Factor in oocyte assists reprogramming Epigenetics direct transdifferentiation Toward an “artificial cell” on a chip
      Keywords: Robotics
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.782-a
  • [Special Issue Review] The biology of mammalian parenting and its effect
           on offspring social development
    • Authors: James K. Rilling
      Abstract: Parents know the transformative nature of having and caring for a child. Among many mammals, giving birth leads from an aversion to infant stimuli to irresistible attraction. Here, we review the biological mechanisms governing this shift in parental motivation in mammals. Estrogen and progesterone prepare the uterus for embryo implantation and placental development. Prolactin stimulates milk production, whereas oxytocin initiates labor and triggers milk ejection during nursing. These same molecules, interacting with dopamine, also activate specific neural pathways to motivate parents to nurture, bond with, and protect their offspring. Parenting in turn shapes the neural development of the infant social brain. Recent work suggests that many of the principles governing parental behavior and its effect on infant development are conserved from rodent to humans.
      Authors : James K. Rilling, Larry J. Young
      PubDate: 2014-08-15
      DOI: 10.1126/science.1252723
  • [Special Issue Review] Preterm labor: One syndrome, many causes
    • Authors: Roberto Romero
      Abstract: Preterm birth is associated with 5 to 18% of pregnancies and is a leading cause of infant morbidity and mortality. Spontaneous preterm labor, a syndrome caused by multiple pathologic processes, leads to 70% of preterm births. The prevention and the treatment of preterm labor have been long-standing challenges. We summarize the current understanding of the mechanisms of disease implicated in this condition and review advances relevant to intra-amniotic infection, decidual senescence, and breakdown of maternal-fetal tolerance. The success of progestogen treatment to prevent preterm birth in a subset of patients at risk is a cause for optimism. Solving the mystery of preterm labor, which compromises the health of future generations, is a formidable scientific challenge worthy of investment.
      Authors : Roberto Romero, Sudhansu K. Dey, Susan J. Fisher
      PubDate: 2014-08-15
      DOI: 10.1126/science.1251816
  • [Special Issue Review] Neural control of maternal and paternal behaviors
    • Authors: Catherine Dulac
      Abstract: Parental care, including feeding and protection of young, is essential for the survival as well as mental and physical well-being of the offspring. A large variety of parental behaviors has been described across species and sexes, raising fascinating questions about how animals identify the young and how brain circuits drive and modulate parental displays in males and females. Recent studies have begun to uncover a striking antagonistic interplay between brain systems underlying parental care and infant-directed aggression in both males and females, as well as a large range of intrinsic and environmentally driven neural modulation and plasticity. Improved understanding of the neural control of parental interactions in animals should provide novel insights into the complex issue of human parental care in both health and disease.
      Authors : Catherine Dulac, Lauren A. O’Connell, Zheng Wu
      PubDate: 2014-08-15
      DOI: 10.1126/science.1253291
  • [Special Issue News] An experiment in zero parenting
    • Authors: Eliot Marshall
      Abstract: A controversial study of Romanian orphans reveals long-term harm to the intellect. Author: Eliot Marshall
      Keywords: Parenting
      PubDate: 2014-08-15
      DOI: 10.1126/science.345.6198.752
  • [Editorial] Maternal mental illness
    • Authors: Katy B. Kozhimannil
      Abstract: In the United States, more than half a million women experience postpartum depression every year; among teens and low-income mothers, the rate is one in four. For many depressed mothers, symptoms begin during pregnancy and may also include disabling anxiety. In addition, maternal mental illness adversely affects infant brain development and subsequent social and emotional health as a result of inadequate prenatal care, poor birth outcomes, and impaired parenting practices. The broad implications of these disorders have led several states to require perinatal depression screening and/or education. Also, a provision of the U.S. Affordable Care Act calls for further research on screening and treatment. These policies are a good start, but laws already on the books must be adequately funded and evaluated. In addition, there are immediate policy actions that can be taken to improve the well-being of mothers and families.
      Authors : Katy B. Kozhimannil, Helen Kim
      PubDate: 2014-08-15
      DOI: 10.1126/science.1259614
  • [Special Issue Review] Parenting from before conception
    • Authors: Michelle Lane
      Abstract: At fertilization, the gametes endow the embryo with a genomic blueprint, the integrity of which is affected by the age and environmental exposures of both parents. Recent studies reveal that parental history and experiences also exert effects through epigenomic information not contained in the DNA sequence, including variations in sperm and oocyte cytosine methylation and chromatin patterning, noncoding RNAs, and mitochondria. Transgenerational epigenetic effects interact with conditions at conception to program the developmental trajectory of the embryo and fetus, ultimately affecting the lifetime health of the child. These insights compel us to revise generally held notions to accommodate the prospect that biological parenting commences well before birth, even prior to conception.
      Authors : Michelle Lane, Rebecca L. Robker, Sarah A. Robertson
      PubDate: 2014-08-15
      DOI: 10.1126/science.1254400
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