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Science

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ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
Published by American Association for the Advancement of Science (AAAS)

[3 journals]

[Report] Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies
- Authors: Sung-Eun Kim
  Abstract: The scaffold protein Axin has an active role in modulating signaling through the Wnt pathway.
  
  Authors : Sung-Eun Kim, He Huang, Ming Zhao, Xinjun Zhang, Aili Zhang, Mikhail V. Semonov, Bryan T. MacDonald, Xiaowu Zhang, Jose Garcia Abreu, Leilei Peng, Xi He
[Report] Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes
- Authors: Jeremy M. Rock
  Abstract: A scaffold protein provides a two-step regulatory mechanism to control the exit from mitosis in yeast.
  
  Authors : Jeremy M. Rock, Daniel Lim, Lasse Stach, Roksana W. Ogrodowicz, Jamie M. Keck, Michele H. Jones, Catherine C. L. Wong, John R. Yates III, Mark Winey, Stephen J. Smerdon, Michael B. Yaffe, Angelika Amon
[Report] ATAXIN-2 Activates PERIOD Translation to Sustain Circadian Rhythms in Drosophila
- Authors: Chunghun Lim
  Abstract: Fruit fly circadian clock function requires protein translation regulated by an RNA-binding protein.
  
  Authors : Chunghun Lim, Ravi Allada
[Report] A Role for Drosophila ATX2 in Activation of PER Translation and Circadian Behavior
- Authors: Yong Zhang
  Abstract: Fruit fly circadian clock function requires protein translation regulated by an RNA-binding protein.
  
  Authors : Yong Zhang, Jinli Ling, Chunyan Yuan, Raphaëlle Dubruille, Patrick Emery
New Products
- Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
[Podcast] Science Podcast: 17 May Show
- Abstract: Listen to stories on fracking, troubling science software, the science of taste, and more.
[Review] Impact of Shale Gas Development on Regional Water Quality
- Authors: R. D. Vidic
  Abstract:
  
  Authors : R. D. Vidic, S. L. Brantley, J. M. Vandenbossche, D. Yoxtheimer, J. D. Abad
[Report] Computationally Assisted Identification of Functional Inorganic Materials
- Authors: Matthew S. Dyer
  Abstract: A method using extended building blocks is developed for computationally viable predictions of stable crystal structures.
  
  Authors : Matthew S. Dyer, Christopher Collins, Darren Hodgeman, Philip A. Chater, Antoine Demont, Simon Romani, Ruth Sayers, Michael F. Thomas, John B. Claridge, George R. Darling, Matthew J. Rosseinsky
[Report] A Reconciled Estimate of Glacier Contributions to Sea Level Rise: 2003 to 2009
- Authors: Alex S. Gardner
  Abstract: A model is developed to describe the complex dynamics of dry foams across a range of time and length scales.
  
  Authors : Alex S. Gardner, Geir Moholdt, J. Graham Cogley, Bert Wouters, Anthony A. Arendt, John Wahr, Etienne Berthier, Regine Hock, W. Tad Pfeffer, Georg Kaser, Stefan R. M. Ligtenberg, Tobias Bolch, Martin J. Sharp, Jon Ove Hagen, Michiel R. van den Broeke, Frank Paul
[Report] Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma
- Authors: Peter W. Lewis
  Abstract: Mutations of histones in some cancers result in inhibition of enzymes that lay down epigenetic marks on chromatin. [Also see Perspective by Morgan and Shilatifard]
  
  Authors : Peter W. Lewis, Manuel M. Müller, Matthew S. Koletsky, Francisco Cordero, Shu Lin, Laura A. Banaszynski, Benjamin A. Garcia, Tom W. Muir, Oren J. Becher, C. David Allis
[Report] Invasive Harlequin Ladybird Carries Biological Weapons Against Native Competitors
- Authors: Andreas Vilcinskas
  Abstract: Invasive ladybugs harbor microsporidia that kill nonresistant beetles contributing to the original residents’ decline. [Also see Perspective by Reynolds]
  
  Authors : Andreas Vilcinskas, Kilian Stoecker, Henrike Schmidtberg, Christian R. Röhrich, Heiko Vogel
[Report] Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL
- Authors: Christian Baarlink
  Abstract: A dynamic polymeric actin structure inside the nucleus is part of the serum response in mammalian tissue culture cells.
  
  Authors : Christian Baarlink, Haicui Wang, Robert Grosse
[Perspective] Medicine: (Poly)Combing the Pediatric Cancer Genome for Answers
- Authors: Marc Alard Morgan
  Abstract: Misregulation of the pattern and localization of histone modifications may result in cancer development. [Also see Report by Lewis et al.]
  
  Authors : Marc Alard Morgan, Ali Shilatifard
[Retrospective] Retrospective: Robert G. Edwards (1925–2013)
- Authors: Susan J. Fisher
  Abstract: The work of a pioneer of in vitro fertilization led to the first "test-tube baby" and changed the field of human reproductive biology.
  
  Authors : Susan J. Fisher, Linda C. Giudice
[Research Article] Soft-Chemistry–Based Routes to Epitaxial α-Quartz Thin Films with Tunable Textures
- Authors: A. Carretero-Genevrier
  Abstract: Porous and dense piezoelectric films of α-quartz crystals are epitaxially grown on silicon substrates. [Also see Perspective by Brinker and Clem]
  
  Authors : A. Carretero-Genevrier, M. Gich, L. Picas, J. Gazquez, G. L. Drisko, C. Boissiere, D. Grosso, J. Rodriguez-Carvajal, C. Sanchez
[Research Article] Rationally Designed Complex, Hierarchical Microarchitectures
- Authors: Wim L. Noorduin
  Abstract: Complex solids are crafted through small changes to the solution conditions in a reaction-diffusion coupled system. [Also see Perspective by Vlieg]
  
  Authors : Wim L. Noorduin, Alison Grinthal, L. Mahadevan, Joanna Aizenberg
[Research Article] Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress
- Authors: Santiago Lima
  Abstract: Gram-negative bacteria monitor lipopolysaccharide and outer-membrane protein status to detect and respond to problems.
  
  Authors : Santiago Lima, Monica S. Guo, Rachna Chaba, Carol A. Gross, Robert T. Sauer
[Report] Phase Diagram of the Topological Superfluid 3He Confined in a Nanoscale Slab Geometry
- Authors: L. V. Levitin
  Abstract: Geometrical confinement affects the stability of the superfluid phases of helium-3.
  
  Authors : L. V. Levitin, R. G. Bennett, A. Casey, B. Cowan, J. Saunders, D. Drung, Th. Schurig, J. M. Parpia
[Report] 3D Computational Imaging with Single-Pixel Detectors
- Authors: B. Sun
  Abstract: A computational imaging method is used to reconstruct a three-dimensional scene, without the need for lenses. [Also see Perspective by Faccio and Leach]
  
  Authors : B. Sun, M. P. Edgar, R. Bowman, L. E. Vittert, S. Welsh, A. Bowman, M. J. Padgett
[Book Review] Paleontology: "Fascinating Little Whatzits"
- Authors: Philip Donoghue
  Abstract: Charting how researchers have conceptualized the conodont animal, Knell offers a fresh perspective on the challenges of understanding unusual extinct taxa.
  
  Author: Philip Donoghue
[Books et al.] Books Received
- Abstract: A listing of books received at Science during the week ending 10 May 2013.
[Policy Forum] Computational Science: Troubling Trends in Scientific Software Use
- Authors: Lucas N. Joppa
  Abstract: "Blind trust" is dangerous when choosing software to support research.
  
  Authors : Lucas N. Joppa, Greg McInerny, Richard Harper, Lara Salido, Kenji Takeda, Kenton O'Hara, David Gavaghan, Stephen Emmott
[Perspective] Ecology: Immunity and Invasive Success
- Authors: Stuart E. Reynolds
  Abstract: The Asian harlequin ladybird has successfully invaded ecosystems around the world with the help of a pathogen that it carries. [Also see Report by Vilcinskas et al.]
  
  Author: Stuart E. Reynolds
[Perspective] Cell Biology: Insulin Finds Its Niche
- Authors: Seth W. Cheetham
  Abstract: Localized insulin signaling allows organ-specific rather than organism-level responses to the environmental conditions.
  
  Authors : Seth W. Cheetham, Andrea H. Brand
[Perspective] Materials Science: Quartz on Silicon
- Authors: C. Jeffrey Brinker
  Abstract: The integration of quartz with silicon may provide a route to fabricate advanced piezoelectric devices. [Also see Research Article by Carretero-Genevrier et al.]
  
  Authors : C. Jeffrey Brinker, Paul G. Clem
[Perspective] Virology: Our Viral Inheritance
- Authors: Robin A. Weiss
  Abstract: Viruses incorporated into vertebrate genomes may reemerge after long periods of dormancy to play a range of biological roles in their host.
  
  Authors : Robin A. Weiss, Jonathan P. Stoye
[Perspective] Applied Physics: Ghost Imaging in Three Dimensions
- Authors: Daniele Faccio
  Abstract: Single-pixel detectors can be used to reconstruct three-dimensional images after patterned illumination of an object. [Also see Report by Sun et al.]
  
  Authors : Daniele Faccio, Jonathan Leach
[Perspective] Materials Science: Complexity from Simplicity
- Authors: Elias Vlieg
  Abstract: Manipulation of crystal growth conditions results in the controlled formation of complex micrometer-scale shapes. [Also see Research Article by Noorduin et al.]
  
  Author: Elias Vlieg
[News Focus] From Quarry to Temple
- Authors: Helen Pickersgill
  Abstract: Two thousand years after the Kizilburun shipwreck, excavating archaeologists have figured out exactly where it came from, where it was headed, and why.
  
  Author: Helen Pickersgill
[News Focus] Food Science: Following the Flavor
- Authors: Kai Kupferschmidt
  Abstract: Scientists are beginning to unravel why we love some types of food and hate others. It's a vastly more complex topic than they once thought.
  
  Author: Kai Kupferschmidt
[News Focus] A Floating Lab Explores the Fringes of Science and Gastronomy
- Authors: Kevin Krajick
  Abstract: Ben Reade and the Nordic Food Lab are part of a movement known as molecular gastronomy that started in the 1990s as a project to understand how ingredients are transformed during cooking.
  
  Author: Kevin Krajick
[Letter] China's "Love Canal" Moment?
- Authors: Chunmiao Zheng
  Abstract:
  
  Authors : Chunmiao Zheng, Jie Liu
[Letter] The True Challenge of Giant Marine Reserves
- Authors: David M. Kaplan
  Abstract:
  
  Authors : David M. Kaplan, Pascal Bach, Sylvain Bonhommeau, Emmanuel Chassot, Pierre Chavance, Laurent Dagorn, Tim Davies, Sibylle Dueri, Rick Fletcher, Alain Fonteneau, Jean-Marc Fromentin, Daniel Gaertner, John Hampton, Ray Hilborn, Alistair Hobday, Robert Kearney, Pierre Kleiber, Patrick Lehodey, Francis Marsac, Olivier Maury, Chris Mees, Frédéric Ménard, John Pearce, John Sibert
[Letter] The True Challenge of Giant Marine Reserves—Response
- Authors: Christopher Pala
  Abstract:
  
  Author: Christopher Pala
[Technical Comment] Comment on "Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice"
- Authors: Stanley E. Lazic
  Abstract:
  
  Author: Stanley E. Lazic
[Technical Response] Response to Comment on "Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice"
- Authors: Sandra Giovanoli
  Abstract:
  
  Authors : Sandra Giovanoli, Urs Meyer
[Book Review] Plant Biology: The Life and Times of a Living Fossil
- Authors: J. C. McElwain
  Abstract: In this "biography" of ginkgos, Crane interweaves aspects of the tree's biology and evolution with stories of people who have helped establish the species in cities around the globe.
  
  Author: J. C. McElwain
[News of the Week] Newsmakers
- Abstract: R. Graham Cooks, a chemist at Purdue University in West Lafayette, Indiana, has been awarded the 2013 Dreyfus Prize in the Chemical Sciences. And biochemist Christian de Duve, who helped reveal the internal organization and operation of cells, died on 4 May.
[News & Analysis] Biomedicine: Human Stem Cells From Cloning, Finally
- Authors: Gretchen Vogel
  Abstract: This time it looks like it's for real: Researchers have made personalized human embryonic stem cells with a method similar to how Dolly the sheep was cloned—though with an added jolt of caffeine.
  
  Author: Gretchen Vogel
[News & Analysis] Influenza: Synthetic Vaccine Strain May Speed Up Pandemic Response
- Authors: Kai Kupferschmidt
  Abstract: Researchers publish technique that could shave up to 4 weeks off vaccine production time, which during a pandemic could save tens of thousands of lives.
  
  Author: Kai Kupferschmidt
[News & Analysis] Glaciology: Melting Glaciers, Not Just Ice Sheets, Stoking Sea-Level Rise
- Authors: Richard A. Kerr
  Abstract: A new study says that although field measurements were painting an accurate picture of the few glaciers being monitored, they were not representative of the world's glaciers.
  
  Author: Richard A. Kerr
[News & Analysis] Human Evolution: More Genomes From Denisova Cave Show Mixing of Early Human Groups
- Authors: Elizabeth Pennisi
  Abstract: Analyses of three fossil samples using a powerful new method paint a complex picture of mingling among different ancient human groups.
  
  Author: Elizabeth Pennisi
[News & Analysis] U.S. Science Policy: Lawmakers Await NSF's Response to Query About Grants
- Authors: Jeffrey Mervis
  Abstract: NSF officials must weigh factors such as the preservation of reviewer confidentiality in responding to Representative Lamar Smith's request for the agency to justify five recent research grants.
  
  Author: Jeffrey Mervis
[News Focus] Troubled Waters for Ancient Shipwrecks
- Authors: Heather Pringle
  Abstract: As archaeologists find new ways to pull precious data from wrecks, they are squaring off against those salvaging ships for profit.
  
  Author: Heather Pringle
[News of the Week] Random Sample
- Abstract: Last week, the National Science Foundation announced the winners of the unique Graduate 10K+ initiative addressing President Barack Obama’s call for U.S. high-tech companies to help train 1 million more STEM graduates by 2020. And according to a new study, the key to environmentally friendly sources of protein may be one that makes many Westerners squirm: edible insects.
This Week in Science
- Abstract: Surprise Attack Fracturing Hydrology? Fabricating Quartz Falling Out Stress Inside Out ATAXIN Clock Melting Away Nuclear Actin in Action Confined Helium Modules of Desire EZ Inhibition Signal Scaffolds Cheap Pix
Editors' Choice
- Abstract: Geophysics: Hawaii's Deep Plumbing System Economics: A Look at the Data Pathogens: The End of Antiquity Chemistry: UN Coaxed to Neutrality Chemistry: Shepherding Stem Cells Physics: Spin Thermometers Developmental Biology: Putting on the Brakes
Findings
- Abstract: New Fossils Provide Earliest Glimpse of Ape Origins U.S. East Coast Not So Passive
[Editorial] Impact Factor Distortions
- Authors: Bruce Alberts
  Abstract: Author: Bruce Alberts
[News of the Week] Around the World
- Abstract: In science news around the world, the U.S. Supreme Court backed the agribusiness firm Monsanto on its soybean patents; the Institut Pasteur has denied accusations by a government watchdog that it misleads research donors; and a director at Charité University Hospital is preparing to examine how Cold War patients were informed, how consent was handled, and how doctors dealt with side effects; and more.