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Journal Cover Science
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     ISSN (Print) 0036-8075 - ISSN (Online) 1095-9203
     Published by American Association for the Advancement of Science (AAAS) Homepage  [3 journals]   [SJR: 10.618]   [H-I: 739]
  • Editors' Choice
    • Authors: Elizabeth Pennisi
      Abstract: Document DNA shows agriculture's course Meeting the demands of a complex network Better cloning through expression Neuronal function requires the real deal Parasites are rising with the seas Translating clicks into efficiency The right combination of additives The socioeconomics of good sanitation
      Keywords: Ancient DNA
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1477-a
  • [Research Article] Patient-derived models of acquired resistance can
           identify effective drug combinations for cancer
    • Authors: Adam S. Crystal
      Abstract: Secondary chemotherapies can be developed by screening drug-resistant cells from individual cancer patients.
      Authors : Adam S. Crystal, Alice T. Shaw, Lecia V. Sequist, Luc Friboulet, Matthew J. Niederst, Elizabeth L. Lockerman, Rosa L. Frias, Justin F. Gainor, Arnaud Amzallag, Patricia Greninger, Dana Lee, Anuj Kalsy, Maria Gomez-Caraballo, Leila Elamine, Emily Howe, Wooyoung Hur, Eugene Lifshits, Hayley E. Robinson, Ryohei Katayama, Anthony C. Faber, Mark M. Awad, Sridhar Ramaswamy, Mari Mino-Kenudson, A. John Iafrate, Cyril H. Benes, Jeffrey A. Engelman
      PubDate: 2014-12-19
      DOI: 10.1126/science.1254721
  • [Research Article] MAVS, cGAS, and endogenous retroviruses in
           T-independent B cell responses
    • Authors: Ming Zeng
      Abstract: Endogenous retroviruses materially contribute to humoral immunity in mice. [Also see Perspective by Grasset and Cerutti]
      Authors : Ming Zeng, Zeping Hu, Xiaolei Shi, Xiaohong Li, Xiaoming Zhan, Xiao-Dong Li, Jianhui Wang, Jin Huk Choi, Kuan-wen Wang, Tiana Purrington, Miao Tang, Maggy Fina, Ralph J. DeBerardinis, Eva Marie Y. Moresco, Gabriel Pedersen, Gerald M. McInerney, Gunilla B. Karlsson Hedestam, Zhijian J. Chen, Bruce Beutler
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1486
  • [Association Affairs] Meeting global challenges: Discovery and innovation
           through convergence
    • Authors: Phillip A. Sharp
      Abstract: Integrate biology, physics, engineering, and social science to innovate Author: Phillip A. Sharp
      Keywords: Presidential Address
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3192
  • [Association Affairs] AAAS News and Notes
    • Abstract: A monthly roundup of recent news and projects of Science's publisher, the American Association for the Advancement of Science.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1473
  • This Week in Science
    • Authors: Andrew M. Sugden
      Abstract: Success for Europe's large carnivores? Using ozone below may conserve it above Drug resistance, up close and personal A brief hiccup in deep ocean circulation For the immune system, silence is golden How trans-polar arcs transpire above Building transmembrane zinc transporters Look, pathologists! No lens! Controlling the state of dynamic proteins Modeling brain cancer from stem to stern Endogenous retroviruses trigger B cells Big impact from a well-placed shake Dispersing catalytic gold as widely as possible Nanoparticle growth starts at the edges Stark influence on reaction rates Promoters tune gene expression noise Designing activity at an interface Can regional climate change be predicted? Menacing exosomes spread cancer Stopping inflammation after infection
      Keywords: Conservation
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1476-a
  • [Letter] Retraction
    • Authors: Giuseppe Lia
      Authors : Giuseppe Lia, Bénédicte Michel, Jean-François Allemand
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1466-a
  • [Letter] On the origin of feathers
    • Authors: Gerald Mayr
      Abstract: Author: Gerald Mayr
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1466-b
  • [Letter] On the origin of feathers—Response
    • Authors: Marie-Claire Koschowitz
      Authors : Marie-Claire Koschowitz, Markus Lambertz, Christian Fischer, P. Martin Sander
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1466-c
  • [Technical Comment] Comment on “A 12-million-year temperature
           history of the tropical Pacific Ocean”
    • Authors: Ana Christina Ravelo
      Abstract: Zhang et al. (Reports, 4 April 2014, p. 84) interpret TEX86 and U37K' paleotemperature data as providing a fundamentally new view of tropical Pacific climate during the warm Pliocene period. We argue that, within error, their Pliocene data actually support previously published data indicating average western warm-pool temperature similar to today and a reduced zonal gradient, referred to as a permanent El Niño–like state.
      Authors : Ana Christina Ravelo, Kira Trillium Lawrence, Alexey Fedorov, Heather Louise Ford
      PubDate: 2014-12-19
      DOI: 10.1126/science.1257618
  • [Technical Response] Response to Comment on “A 12-million-year
           temperature history of the tropical Pacific Ocean”
    • Authors: Yi Ge Zhang
      Abstract: Contrary to our conclusions, Ravelo et al. argue that our TEX86-based sea surface temperature (SST) records do not conflict with the supposition of “permanent El Niño–like” conditions during the early Pliocene. We show that the way Ravelo et al. treat the existing temperature data perpetuates an inaccurate impression of cooler Pacific warm-pool SSTs and low equatorial temperature gradients in the past.
      Authors : Yi Ge Zhang, Mark Pagani, Zhonghui Liu
      PubDate: 2014-12-19
      DOI: 10.1126/science.1257930
  • [Perspective] More than fine tuning
    • Authors: Peter Hildebrandt
      Abstract: Local electric fields accelerate an enzymatic reaction [Also see Report by Fried et al.] Author: Peter Hildebrandt
      Keywords: Biochemistry
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa2878
  • [Perspective] For pediatric glioma, leave no histone unturned
    • Authors: Oren J. Becher
      Abstract: Examining histone mutations points to possible therapies for a lethal brain tumor [Also see Report by Funato et al.]
      Authors : Oren J. Becher, Robert J. Wechsler-Reya
      Keywords: Cancer
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3814
  • [Perspective] Malicious exosomes
    • Authors: Eleni Anastasiadou
      Abstract: Nanovesicles derived from cells of cancer patients carry microRNAs that initiate tumor growth in normal cells
      Authors : Eleni Anastasiadou, Frank J. Slack
      Keywords: Cancer
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa4024
  • [Perspective] Projecting regional change
    • Authors: Alex Hall
      Abstract: How accurate are regional projections of climate change derived from downscaling global climate model results? Author: Alex Hall
      Keywords: Climate
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa0629
  • [Book Review] Einstein online
    • Authors: Andrew Robinson
      Abstract: Author: Andrew Robinson
      Keywords: Digital Archives
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3615
  • [Book Review] The body never lies
    • Authors: Yevgeniya Nusinovich
      Abstract: Author: Yevgeniya Nusinovich
      Keywords: Forensic Science
      PubDate: 2014-12-19
      DOI: 10.1126/science.1260578
  • [Book Review] Finding our place among the stars
    • Authors: Salman Hameed
      Abstract: Author: Salman Hameed
      Keywords: Film
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3646
  • [Book Review] Melting Away
    • Keywords: Books in Brief
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3325
  • [Books et al.] Books Received
    • Abstract: A listing of books received at Science during the week ending 12 December 2014.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1465-b
  • [Feature] Areas to watch in 2015
    • Abstract: Science is a moving target. In addition to looking back on achievements of the previous year, the Breakthrough staff also hazards a few informed guesses about developments likely to make news in months to come.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1450-a
  • [Feature] Breakdown + Breakdown runners-up
    • Abstract: Slow international response and missed opportunities to contain the outbreak make this year's Ebola epidemic Science's breakdown of the year. Also, Breakthrough staff chose a few of this year's notable flaps, stumbles, and reverses as runners-up.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1450-b
  • [Policy Forum] Fixing problems with cell lines
    • Authors: Jon R. Lorsch
      Abstract: Technologies and policies can improve authentication
      Authors : Jon R. Lorsch, Francis S. Collins, Jennifer Lippincott-Schwartz
      Keywords: Cell Biology
      PubDate: 2014-12-19
      DOI: 10.1126/science.1259110
  • [Perspective] Retroviral help for B cells
    • Authors: Emilie K. Grasset
      Abstract: Silent retroviruses present in the human genome help B cells launch a rapid response to pathogenic antigens [Also see Research Article by Zeng et al.]
      Authors : Emilie K. Grasset, Andrea Cerutti
      Keywords: Immunology
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa3263
  • [Perspective] What I cannot create, I do not understand
    • Authors: Andrei N. Lupas
      Abstract: A designed protein transports ions across a membrane [Also see Report by Joh et al.] Author: Andrei N. Lupas
      Keywords: Protein Design
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa2721
  • [In Depth] The thoroughly bred horse
    • Authors: Ann Gibbons
      Abstract: Genomes from ancient horses show the genetic changes wrought by domestication—and their costs. Author: Ann Gibbons
      Keywords: Ancient DNA
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1439
  • [In Depth] Celebrated biodiversity institute faces financial crisis
    • Authors: Lizzie Wade
      Abstract: New government rethinks plan to take over INBio's money-losing theme parks. Author: Lizzie Wade
      Keywords: Costa Rica
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1440
  • [In Depth] Ambitious children's study meets disappointing end
    • Authors: Jocelyn Kaiser
      Abstract: After 14 years and $1.2 billion spent, design and management troubles topple National Children's Study. Author: Jocelyn Kaiser
      Keywords: Biomedical Research
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1441
  • [Feature] Comet Breakthrough of the Year + People's choice
    • Authors: Eric Hand
      Abstract: Rosetta's short-lived lander grabbed the headlines, but the ongoing orbital mission is the real news for science. And this year, Science decided to give its readers a say in picking their own top breakthroughs of 2014. Author: Eric Hand
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1442
  • [Feature] Runners-up
    • Abstract: In addition to its Breakthrough of the Year, Science named nine runners-up as significant scientific achievements of 2014.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1444
  • [Feature] Scorecard for 2014
    • Abstract: Every year, the Breakthrough staff picks scientific developments likely to make news in the coming months.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1449
  • [Working Life] For the love of ferns
    • Authors: Karen Perkins
      Abstract: Author: Karen Perkins
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1586
  • [Editorial] Breakthrough to our origins
    • Authors: Marcia McNutt
      Abstract: Long before I dreamed of becoming a scientist, I wondered why Earth was teeming with life, while Mars was a barren, rocky outpost and Venus was shrouded in a dense atmosphere. Somewhere, I read that comets were the reason. Strike a rocky planet with one volatile- and organic-rich comet and an Earth-like environment results. Two comets produce a Venus. No comets: Mars. Of course, this theory was far too simple to explain the differences in the evolution of the inner planets, but no one had ever explored comets up close to know how they might alter a planet's composition and history—until now. Last month, after many years of planning and a decade in transit, the European Space Agency's spacecraft Rosetta reached Comet 67P/Churyumov-Gerasimenko, surveyed landing sites, and deployed its probe, Philae, to execute the first-ever soft landing on a comet's surface (see the News story, p. 1442). Author: Marcia McNutt
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa4569
  • [In Brief] This week's section
    • Abstract: A roundup of weekly science policy and related news.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1434
  • [In Depth] U.S. fusion effort melts down
    • Authors: Adrian Cho
      Abstract: Scientific community battles with its federal office. Author: Adrian Cho
      Keywords: Energy Research
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1436
  • [In Depth] Science agencies make gains despite tight U.S. budget
    • Authors: Jeffrey Mervis
      Abstract: NASA, NSF among 2015 winners in difficult year.
      Authors : Jeffrey Mervis, David Malakoff
      Keywords: Research Funding
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1437
  • [Errata] Erratum for the Perspective: “Mathematical models for
           emerging disease” by A. Dobson
    • Keywords: ERRATUM
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa4792
  • [Research Article] Evolution of oligomeric state through allosteric
           pathways that mimic ligand binding
    • Authors: Tina Perica
      Abstract: Mutations can alter protein conformations in the same way that allosteric small molecules do.
      Authors : Tina Perica, Yasushi Kondo, Sandhya P. Tiwari, Stephen H. McLaughlin, Katherine R. Kemplen, Xiuwei Zhang, Annette Steward, Nathalie Reuter, Jane Clarke, Sarah A. Teichmann
      PubDate: 2014-12-19
      DOI: 10.1126/science.1254346
  • [New Products] New Products
    • Abstract: A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1569-a
  • [Podcast] Science Podcast: 19 December Show
    • Abstract: On this week's show: Breakthrough of the year and a yearly news roundup.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1569-b
  • [Business Office Feature] The Chinese Research Paradigm: Addressing Global
           Science Issues
    • Abstract: This special supplement to Science collects together summaries of both current and previous quality research conducted at Tianjin University and supported by the "973" Program, a central government funded initiative initiated by the Chinese Ministry of Science and Technology in June 1997. Its primary goal is to promote the advancement of science and technology in China, emphasizing basic and applied research that is aligned with national interests that will support national economic and social development. The program covers a very diverse range of research areas, from nanotechnology to energy efficiency to agriculture. Although the research covered in this supplement is only a sample of the many projects at Tianjin University, it is intended to provide the reader with a sense of the diversity and depth of work being performed under the "973" Program. As this program grows in the future, further scientific and technological advances will no doubt be forthcoming that benefit not only China and its people, but also researchers and citizens around the world.Read the booklet (PDF, 11MB)Read the e-bookletThis booklet brought to you by the Science/AAAS Custom Publishing Office.
      PubDate: 2014-12-19
      DOI: 10.1126/science.346.6216.1569-c
  • [Report] Use of human embryonic stem cells to model pediatric gliomas with
           H3.3K27M histone mutation
    • Authors: Kosuke Funato
      Abstract: A stem cell model of a lethal brain tumor in children shows how a recurrent histone mutation leads to cancer. [Also see Perspective by Becher and Wechsler-Reya]
      Authors : Kosuke Funato, Tamara Major, Peter W. Lewis, C. David Allis, Viviane Tabar
      PubDate: 2014-12-19
      DOI: 10.1126/science.1253799
  • [Report] Promoter architecture dictates cell-to-cell variability in gene
    • Authors: Daniel L. Jones
      Abstract: Changes to regulatory DNA tune gene expression noise in a quantitatively predictable way.
      Authors : Daniel L. Jones, Robert C. Brewster, Rob Phillips
      PubDate: 2014-12-19
      DOI: 10.1126/science.1255301
  • [Report] Detection of self-reactive CD8+ T cells with an anergic phenotype
           in healthy individuals
    • Authors: Yuka Maeda
      Abstract: Healthy individuals harbor “silenced” self-reactive T cells.
      Authors : Yuka Maeda, Hiroyoshi Nishikawa, Daisuke Sugiyama, Danbee Ha, Masahide Hamaguchi, Takuro Saito, Megumi Nishioka, James B. Wing, Dennis Adeegbe, Ichiro Katayama, Shimon Sakaguchi
      PubDate: 2014-12-19
      DOI: 10.1126/science.aaa1292
  • [Report] De novo design of a transmembrane Zn2+-transporting four-helix
    • Authors: Nathan H. Joh
      Abstract: Computational design yields a transmembrane protein that selectively transports zinc cations. [Also see Perspective by Lupas]
      Authors : Nathan H. Joh, Tuo Wang, Manasi P. Bhate, Rudresh Acharya, Yibing Wu, Michael Grabe, Mei Hong, Gevorg Grigoryan, William F. DeGrado
      PubDate: 2014-12-19
      DOI: 10.1126/science.1261172
  • [Report] A designed supramolecular protein assembly with in vivo enzymatic
    • Authors: Woon Ju Song
      Abstract: A monomeric redox protein can be engineered into a tetrameric β-lactamase that confers antibiotic resistance in vivo.
      Authors : Woon Ju Song, F. Akif Tezcan
      PubDate: 2014-12-19
      DOI: 10.1126/science.1259680
  • [Report] Extreme electric fields power catalysis in the active site of
           ketosteroid isomerase
    • Authors: Stephen D. Fried
      Abstract: Vibrational spectroscopy pinpoints a surprisingly large local electric field where an enzyme binds its substrate. [Also see Perspective by Hildebrandt]
      Authors : Stephen D. Fried, Sayan Bagchi, Steven G. Boxer
      PubDate: 2014-12-19
      DOI: 10.1126/science.1259802
  • [Report] A stagnation event in the deep South Atlantic during the last
           interglacial period
    • Authors: Christopher T. Hayes
      Abstract: Southern Hemisphere deep water formation stuttered during the last interglacial period.
      Authors : Christopher T. Hayes, Alfredo Martínez-García, Adam P. Hasenfratz, Samuel L. Jaccard, David A. Hodell, Daniel M. Sigman, Gerald H. Haug, Robert F. Anderson
      PubDate: 2014-12-19
      DOI: 10.1126/science.1256620
  • [Report] Recovery of large carnivores in Europe’s modern
           human-dominated landscapes
    • Authors: Guillaume Chapron
      Abstract: Many populations of brown bears, lynx, grey wolves, and wolverines persist successfully outside protected areas in Europe.
      Authors : Guillaume Chapron, Petra Kaczensky, John D. C. Linnell, Manuela von Arx, Djuro Huber, Henrik Andrén, José Vicente López-Bao, Michal Adamec, Francisco Álvares, Ole Anders, Linas Balčiauskas, Vaidas Balys, Péter Bedő, Ferdinand Bego, Juan Carlos Blanco, Urs Breitenmoser, Henrik Brøseth, Luděk Bufka, Raimonda Bunikyte, Paolo Ciucci, Alexander Dutsov, Thomas Engleder, Christian Fuxjäger, Claudio Groff, Katja Holmala, Bledi Hoxha, Yorgos Iliopoulos, Ovidiu Ionescu, Jasna Jeremić, Klemen Jerina, Gesa Kluth, Felix Knauer, Ilpo Kojola, Ivan Kos, Miha Krofel, Jakub Kubala, Saša Kunovac, Josip Kusak, Miroslav Kutal, Olof Liberg, Aleksandra Majić, Peep Männil, Ralph Manz, Eric Marboutin, Francesca Marucco, Dime Melovski, Kujtim Mersini, Yorgos Mertzanis, Robert W. Mysłajek, Sabina Nowak, John Odden, Janis Ozolins, Guillermo Palomero, Milan Paunović, Jens Persson, Hubert Potočnik, Pierre-Yves Quenette, Georg Rauer, Ilka Reinhardt, Robin Rigg, Andreas Ryser, Valeria Salvatori, Tomaž Skrbinšek, Aleksandar Stojanov, Jon E. Swenson, László Szemethy, Aleksandër Trajçe, Elena Tsingarska-Sedefcheva, Martin Váňa, Rauno Veeroja, Petter Wabakken, Manfred Wölfl, Sybille Wölfl, Fridolin Zimmermann, Diana Zlatanova, Luigi Boitani
      PubDate: 2014-12-19
      DOI: 10.1126/science.1257553
  • [Report] Element-specific anisotropic growth of shaped platinum alloy
    • Authors: Lin Gan
      Abstract: Platinum-rich phases that initially form create the edges and corners of octahedral nanoparticle alloys.
      Authors : Lin Gan, Chunhua Cui, Marc Heggen, Fabio Dionigi, Stefan Rudi, Peter Strasser
      PubDate: 2014-12-19
      DOI: 10.1126/science.1261212
  • [Report] Direct observation of closed magnetic flux trapped in the
           high-latitude magnetosphere
    • Authors: R. C. Fear
      Abstract: Plasma observed in magnetotail lobes results from trapped magnetic flux and is also manifested as transpolar arc auroras.
      Authors : R. C. Fear, S. E. Milan, R. Maggiolo, A. N. Fazakerley, I. Dandouras, S. B. Mende
      PubDate: 2014-12-19
      DOI: 10.1126/science.1257377
  • [Report] Toward control of electron transfer in donor-acceptor molecules
           by bond-specific infrared excitation
    • Authors: Milan Delor
      Abstract: Vibrational excitation can modulate electron transfer probabilities in real time.
      Authors : Milan Delor, Paul A. Scattergood, Igor V. Sazanovich, Anthony W. Parker, Gregory M. Greetham, Anthony J. H. M. Meijer, Michael Towrie, Julia A. Weinstein
      PubDate: 2014-12-19
      DOI: 10.1126/science.1259995
  • [Report] One-pot room-temperature conversion of cyclohexane to adipic acid
           by ozone and UV light
    • Authors: Kuo Chu Hwang
      Abstract: A photochemical route to a nylon precursor could prove more environmentally benign than current approaches.
      Authors : Kuo Chu Hwang, Arunachalam Sagadevan
      PubDate: 2014-12-19
      DOI: 10.1126/science.1259684
  • [Report] Catalytically active Au-O(OH)x- species stabilized by alkali ions
           on zeolites and mesoporous oxides
    • Authors: Ming Yang
      Abstract: Alkali atoms help disperse catalytically active gold on high–surface-area alumina and silica supports.
      Authors : Ming Yang, Sha Li, Yuan Wang, Jeffrey A. Herron, Ye Xu, Lawrence F. Allard, Sungsik Lee, Jun Huang, Manos Mavrikakis, Maria Flytzani-Stephanopoulos
      PubDate: 2014-12-19
      DOI: 10.1126/science.1260526
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