for Journals by Title or ISSN
for Articles by Keywords
help
Followed Journals
Journal you Follow: 0
 
Sign Up to follow journals, search in your chosen journals and, optionally, receive Email Alerts when new issues of your Followed Journals are published.
Already have an account? Sign In to see the journals you follow.
Journal Cover
Proceedings of the National Academy of Sciences
Journal Prestige (SJR): 6.092
Citation Impact (citeScore): 9
Number of Followers: 1061  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0027-8424 - ISSN (Online) 1091-6490
Published by PNAS Homepage  [1 journal]
  • In This Issue [This Week in PNAS]
    • Pages: 5199 - 5201
      Abstract: Blue whale memory and migration Blue whale (Balaenoptera musculus) migrates in the California current. Image courtesy of Jeremy A. Goldbogen (Stanford University, Stanford, CA) and the Duke Marine Robotics and Remote Sensing Lab. Many migrant species track waves of high-quality food resources across landscapes. Although there is extensive research on...
      Keywords: In This Issue
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/iti1219116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Discussion of forest definitions and tree cover estimates for Haiti
           [Biological Sciences]
    • Authors: Peter J. Wampler; Andrew Tarter, Rob Bailis, Klas Sander, Wanxiao Sun
      Pages: 5202 - 5203
      Abstract: In PNAS, Hedges et al. (1) estimate that only 0.32% of “primary forest” cover of Haiti remains. They argue the situation is dire and predict that Haiti will have no remaining primary forest by 2035 (1). We highlight several assumptions in their forest definition parameters and subsequent national extrapolation that...
      Keywords: Letters, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1901163116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Reply to Wampler et al.: Deforestation and biodiversity loss should not be
           sugarcoated [Biological Sciences]
    • Authors: S. Blair Hedges; Warren B. Cohen, Joel Timyan, Zhiqiang Yang
      Pages: 5204 - 5204
      Abstract: We determined that Haiti has less than 1% of its original primary (virgin) forest and will likely lose it all in the next two decades at the current rate (1). We focused on primary forest because of its close connection with species survival (2). The letter by Wampler et al....
      Keywords: Letters, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1901879116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Universal and robust assessment of circadian time' [Biological
           Sciences]
    • Authors: Emma E. Laing; Carla S. Moller–Levet, Simon N. Archer, Derk–Jan Diȷk
      Pages: 5205 - 5205
      Abstract: In PNAS, Braun et al. (1) describe the algorithm TimeSignature. We make the following observations. First, circadian time refers to the phase of internal biological clocks. Any algorithm assessing this should be validated against gold-standard markers of internal circadian phase. For example, the phase of the melatonin rhythm is considered...
      Keywords: Letters
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1817119116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Reply to Laing et al.: Accurate prediction of circadian time across
           platforms [Biological Sciences]
    • Authors: Rosemary Braun; William L. Kath, Marta Iwanaszko, Elzbieta Kula-Eversole, Sabra M. Abbott, Kathryn J. Reid, Phyllis C. Zee, Ravi Allada
      Pages: 5206 - 5208
      Abstract: TimeSignature’s power is that it is highly accurate across transcriptomic platforms and experimental protocols. TimeSignature can be trained using data from a single platform/study and be applied to independent data without additional processing. Demonstrating this robustness and generalizability required applying TimeSignature to as diverse a set of studies as possible...
      Keywords: Letters
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819173116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Opinion: Governing the recreational dimension of global fisheries
           [Sustainability Science]
    • Authors: Robert Arlinghaus; Joshua K. Abbott, Eli P. Fenichel, Stephen R. Carpenter, Len M. Hunt, Josep Alos, Thomas Klefoth, Steven J. Cooke, Ray Hilborn, Olaf P. Jensen, Michael J. Wilberg, John R. Post, Michael J. Manfredo
      Pages: 5209 - 5213
      Abstract: Fisheries provide food. In industrialized nations, the overwhelming portion of seafood comes from a small number of commercial fishers and increasingly aquaculture (1). Fisheries also contribute to leisure and recreation. In developed nations, 1 in 10 people fishes for pleasure, amounting to at least 220 million recreational fishers worldwide (2,...
      Keywords: Opinions, Front Matter, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1902796116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Polariton chemistry: Thinking inside the (photon) box [Physics]
    • Authors: Joel Yuen-Zhou; Vinod M. Menon
      Pages: 5214 - 5216
      Abstract: The study of single quantum objects embedded in confined electromagnetic environments is the main focus of the field of cavity quantum electrodynamics (CQED). According to a recent historical account by the 2012 Nobel laureate Sergei Haroche (1), the origins of this field can be traced back to the early days...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1900795116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Migrating whales depend on memory to exploit reliable resources [Ecology]
    • Authors: William F. Fagan
      Pages: 5217 - 5219
      Abstract: Animal migrations, which can span hundreds to thousands of kilometers and require journeys lasting weeks to months, are fascinating biological phenomena. Across systems and species, key questions focus on the behavioral mechanisms that facilitate successful migrations. Perception, information sharing among individuals, and various forms of memory separate migration from other...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1901803116
      Issue No: Vol. 116, No. 12 (2019)
       
  • In a globally warming world, insects act locally to manipulate their own
           microclimate [Ecology]
    • Authors: Michael Kaspari
      Pages: 5220 - 5222
      Abstract: A key challenge, as CO2 accumulates and Earth warms, is to predict the responses of ecological systems—the suite of interacting populations embedded in the abiotic arena of temperature, moisture, and biogeochemistry. Thermal performance theory (1–3) has come to the fore as a powerful approach toward understanding such biotic change. Thermal...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1901972116
      Issue No: Vol. 116, No. 12 (2019)
       
  • COX-2 mediates tumor-stromal prolactin signaling to initiate tumorigenesis
           [Cell Biology]
    • Authors: Yu Zheng; Valentine Comaills, Risa Burr, Gaylor Boulay, David T. Miyamoto, Ben S. Wittner, Erin Emmons, Srinjoy Sil, Michael W. Koulopoulos, Katherine T. Broderick, Eric Tai, Shruthi Rengarajan, Anupriya S. Kulkarni, Toshi Shioda, Chin-Lee Wu, Sridhar Ramaswamy, David T. Ting, Mehmet Toner, Miguel N. Rivera, Shyamala Maheswaran, Daniel A. Haber
      Pages: 5223 - 5232
      Abstract: Tumor-stromal communication within the microenvironment contributes to initiation of metastasis and may present a therapeutic opportunity. Using serial single-cell RNA sequencing in an orthotopic mouse prostate cancer model, we find up-regulation of prolactin receptor as cancer cells that have disseminated to the lungs expand into micrometastases. Secretion of the ligand...
      Keywords: Inaugural Articles
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819303116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Role of economics in analyzing the environment and sustainable development
           [Introductions]
    • Authors: Stephen Polasky; Catherine L. Kling, Simon A. Levin, Stephen R. Carpenter, Gretchen C. Daily, Paul R. Ehrlich, Geoffrey M. Heal, Jane Lubchenco
      Pages: 5233 - 5238
      Abstract: The environmental sciences have documented large and worrisome changes in earth systems, from climate change and loss of biodiversity, to changes in hydrological and nutrient cycles and depletion of natural resources (1–12). These global environmental changes have potentially large negative consequences for future human well-being, and raise questions about whether...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1901616116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Seeking natural capital projects: Forest fires, haze, and early-life
           exposure in Indonesia [Colloquium Paper]
    • Authors: Jie-Sheng Tan-Soo; Subhrendu K. Pattanayak
      Pages: 5239 - 5245
      Abstract: Natural capital will be depleted rapidly and excessively if the long-term, offsite impacts of depletion are ignored. By examining the case of tropical forest burning, we illustrate such myopia: Pursuit of short-term economic gains results in air pollution that causes long-term, irreversible health impacts. We integrate longitudinal data on prenatal...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802876116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Short-term impact of PM2.5 on contemporaneous asthma medication use:
           Behavior and the value of pollution reductions [Colloquium Paper]
    • Authors: Austin M. Williams; Daniel J. Phaneuf, Meredith A. Barrett, Jason G. Su
      Pages: 5246 - 5253
      Abstract: Asthma ranks among the most costly of chronic diseases, accounting for over $50 billion annually in direct medical expenditures in the United States. At the same time, evidence has accumulated that fine particulate matter pollution can exacerbate asthma symptoms and generate substantial economic costs. To measure these costs, we use...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1805647115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Assessing ecological infrastructure investments [Colloquium Paper]
    • Authors: Wiktor Adamowicz; Laura Calderon-Etter, Alicia Entem, Eli P. Fenichel, Jefferson S. Hall, Patrick Lloyd-Smith, Fred L. Ogden, Jason A. Regina, Mani Rouhi Rad, Robert F. Stallard
      Pages: 5254 - 5261
      Abstract: Conventional markets can underprovide ecosystem services. Deliberate creation of a market for ecosystem services [e.g., a payments for ecosystem services (PES) scheme] can close the gap. The new ecosystem service market alters behaviors and quantities of ecosystem service provided and reveals prices for the ecosystems service: a market-clearing equilibrium. Assessing...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802883116
      Issue No: Vol. 116, No. 12 (2019)
       
  • The low but uncertain measured benefits of US water quality policy
           [Colloquium Paper]
    • Authors: David A. Keiser; Catherine L. Kling, Joseph S. Shapiro
      Pages: 5262 - 5269
      Abstract: US investment to decrease pollution in rivers, lakes, and other surface waters has exceeded $1.9 trillion since 1960, and has also exceeded the cost of most other US environmental initiatives. These investments come both from the 1972 Clean Water Act and the largely voluntary efforts to control pollution from agriculture...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802870115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Environmental catastrophes and mitigation policies in a multiregion world
           [Colloquium Paper]
    • Authors: Timothy Besley; Avinash Dixit
      Pages: 5270 - 5276
      Abstract: In this paper we present a simple model for assessing the willingness to pay for reductions in the risk associated with catastrophic climate change. The model is extremely tractable and applies to a multiregion world but with global externalities and has five key features: (i) Neither the occurrence nor the...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802864115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Knowledge infrastructure and safe operating spaces in social-ecological
           systems [Colloquium Paper]
    • Authors: John M. Anderies; Jean-Denis Mathias, Marco A. Janssen
      Pages: 5277 - 5284
      Abstract: Maintaining safe operating spaces for exploited natural systems in the face of uncertainty is a key sustainability challenge. This challenge can be viewed as a problem in which human society must navigate in a limited space of acceptable futures in which humans enjoy sufficient well-being and avoid crossing planetary boundaries....
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802885115
      Issue No: Vol. 116, No. 12 (2019)
       
  • On the use of group performance and rights for environmental protection
           and resource management [Colloquium Paper]
    • Authors: Matthew J. Kotchen; Kathleen Segerson
      Pages: 5285 - 5292
      Abstract: Environmental and natural resource (ENR) policies that focus on group outcomes are common but have received relatively less attention from economists than policies based on individual behavior. Existing research tends to focus on particular contexts, such as water or air quality, fisheries, or land use. This paper discusses unifying themes...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802881115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Testing for crowd out in social nudges: Evidence from a natural field
           experiment in the market for electricity [Colloquium Paper]
    • Authors: Alec Brandon; John A. List, Robert D. Metcalfe, Michael K. Price, Florian Rundhammer
      Pages: 5293 - 5298
      Abstract: This study considers the response of household electricity consumption to social nudges during peak load events. Our investigation considers two social nudges. The first targets conservation during peak load events, while the second promotes aggregate conservation. Using data from a natural field experiment with 42,100 households, we find that both...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802874115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Sustaining cooperation through self-sorting: The good, the bad, and the
           conditional [Colloquium Paper]
    • Authors: Karen Evelyn Hauge; Kjell Arne Brekke, Karine Nyborg, Jo Thori Lind
      Pages: 5299 - 5304
      Abstract: In four public-good game experiments, we study self-sorting as a means to facilitate cooperation in groups. When individuals can choose to join groups precommitted to charity, such groups sustain cooperation toward the group’s local public good. By eliciting subjects’ conditional contribution profiles, we find that subjects who prefer the charity...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802875115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Localized prosocial preferences, public goods, and common-pool resources
           [Colloquium Paper]
    • Authors: Andrew R. Tilman; Avinash K. Dixit, Simon A. Levin
      Pages: 5305 - 5310
      Abstract: The presence of prosocial preferences is thought to reduce significantly the difficulty of solving societal collective action problems such as providing public goods (or reducing public bads). However, prosociality is often limited to members of an in-group. We present a general theoretical model where society is split into subgroups and...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802872115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Causal inference in coupled human and natural systems [Colloquium Paper]
    • Authors: Paul J. Ferraro; James N. Sanchirico, Martin D. Smith
      Pages: 5311 - 5318
      Abstract: Coupled human and natural systems (CHANS) are complex, dynamic, interconnected systems with feedback across social and environmental dimensions. This feedback leads to formidable challenges for causal inference. Two significant challenges involve assumptions about excludability and the absence of interference. These two assumptions have been largely unexplored in the CHANS literature,...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development, Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1805563115
      Issue No: Vol. 116, No. 12 (2019)
       
  • The blue paradox: Preemptive overfishing in marine reserves [Colloquium
           Paper]
    • Authors: Grant R. McDermott; Kyle C. Meng, Gavin G. McDonald, Christopher J. Costello
      Pages: 5319 - 5325
      Abstract: Most large-scale conservation policies are anticipated or announced in advance. This risks the possibility of preemptive resource extraction before the conservation intervention goes into force. We use a high-resolution dataset of satellite-based fishing activity to show that anticipation of an impending no-take marine reserve undermines the policy by triggering an...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802862115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Self-selection into payments for ecosystem services programs [Colloquium
           Paper]
    • Authors: B. Kelsey Jack; Seema Jayachandran
      Pages: 5326 - 5333
      Abstract: Designers and funders of payments for ecosystem services (PES) programs have long worried that payments flow to landholders who would have conserved forests even without the program, undermining the environmental benefits (“additionality”) and cost-effectiveness of PES. If landholders self-select into PES programs based on how much conservation they were going...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802868115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Private provision of public goods by environmental groups [Colloquium
           Paper]
    • Authors: Laura Grant; Christian Langpap
      Pages: 5334 - 5340
      Abstract: Many environmental nonprofit groups are assumed to provide public goods. While an extensive literature examines why donors join and give to nonprofits, none directly tests whether donations actually provide public goods. We seek such a test by using a common form of environmental organization: watershed groups. We find their increased...
      Keywords: Sackler Colloquium on Economics, Environment, and Sustainable Development
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1805336115
      Issue No: Vol. 116, No. 12 (2019)
       
  • Time-dependent manufacturing processes lead to a new class of inverse
           problems [Engineering]
    • Authors: Dragos Axinte; John Billingham
      Pages: 5341 - 5343
      Abstract: The control of time-dependent, energy beam manufacturing processes has been achieved in the past through trial-and-error approaches. We identify key research gaps and generic challenges related to inverse problems for these processes that require a multidisciplinary problem-solving approach to tackle them. The generic problems that we identify have a wide...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1900420116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Theory of mechanochemical patterning in biphasic biological tissues
           [Developmental Biology]
    • Authors: Pierre Recho; Adrien Hallou, Edouard Hannezo
      Pages: 5344 - 5349
      Abstract: The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1813255116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Statistics of noisy growth with mechanical feedback in elastic tissues
           [Developmental Biology]
    • Authors: Ojan Khatib Damavandi; David K. Lubensky
      Pages: 5350 - 5355
      Abstract: Tissue growth is a fundamental aspect of development and is intrinsically noisy. Stochasticity has important implications for morphogenesis, precise control of organ size, and regulation of tissue composition and heterogeneity. However, the basic statistical properties of growing tissues, particularly when growth induces mechanical stresses that can in turn affect growth...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1816100116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Fast pressure-jump all-atom simulations and experiments reveal
           site-specific protein dehydration-folding dynamics [Biophysics and
           Computational Biology]
    • Authors: Maxim B. Prigozhin; Yi Zhang, Klaus Schulten, Martin Gruebele, Taras V. Pogorelov
      Pages: 5356 - 5361
      Abstract: As theory and experiment have shown, protein dehydration is a major contributor to protein folding. Dehydration upon folding can be characterized directly by all-atom simulations of fast pressure drops, which create desolvated pockets inside the nascent hydrophobic core. Here, we study pressure-drop refolding of three λ-repressor fragment (λ6–85) mutants computationally...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814927116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Temperature- and rigidity-mediated rapid transport of lipid nanovesicles
           in hydrogels [Biophysics and Computational Biology]
    • Authors: Miaorong Yu; Wenyi Song, Falin Tian, Zhuo Dai, Quanlei Zhu, Ejaj Ahmad, Shiyan Guo, Chunliu Zhu, Haijun Zhong, Yongchun Yuan, Tao Zhang, Xin Yi, Xinghua Shi, Yong Gan, Huajian Gao
      Pages: 5362 - 5369
      Abstract: Lipid nanovesicles are widely present as transport vehicles in living organisms and can serve as efficient drug delivery vectors. It is known that the size and surface charge of nanovesicles can affect their diffusion behaviors in biological hydrogels such as mucus. However, how temperature effects, including those of both ambient...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818924116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Formylglycine-generating enzyme binds substrate directly at a mononuclear
           Cu(I) center to initiate O2 activation [Biochemistry]
    • Authors: Mason J. Appel; Katlyn K. Meier, Julien Lafrance-Vanasse, Hyeongtaek Lim, Chi-Lin Tsai, Britt Hedman, Keith O. Hodgson, John A. Tainer, Edward I. Solomon, Carolyn R. Bertozzi
      Pages: 5370 - 5375
      Abstract: The formylglycine-generating enzyme (FGE) is required for the posttranslational activation of type I sulfatases by oxidation of an active-site cysteine to Cα-formylglycine. FGE has emerged as an enabling biotechnology tool due to the robust utility of the aldehyde product as a bioconjugation handle in recombinant proteins. Here, we show that...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818274116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Encoding biological recognition in a bicomponent cell-membrane mimic
           [Chemistry]
    • Authors: Cesar Rodriguez–Emmenegger; Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benȷamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Moller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
      Pages: 5376 - 5382
      Abstract: Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same periodic and quasiperiodic arrays were subsequently found in block copolymers,...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1821924116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Femtosecond covariance spectroscopy [Chemistry]
    • Authors: Jonathan Owen Tollerud; Giorgia Sparapassi, Angela Montanaro, Shahaf Asban, Filippo Glerean, Francesca Giusti, Alexandre Marciniak, George Kourousias, Fulvio Bille, Federico Cilento, Shaul Mukamel, Daniele Fausti
      Pages: 5383 - 5386
      Abstract: The success of nonlinear optics relies largely on pulse-to-pulse consistency. In contrast, covariance-based techniques used in photoionization electron spectroscopy and mass spectrometry have shown that a wealth of information can be extracted from noise that is lost when averaging multiple measurements. Here, we apply covariance-based detection to nonlinear optical spectroscopy,...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1821048116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Environmental control programs the emergence of distinct functional
           ensembles from unconstrained chemical reactions [Chemistry]
    • Authors: Andrew J. Surman; Marc Rodriguez-Garcia, Yousef M. Abul-Haija, Geoffrey J. T. Cooper, Piotr S. Gromski, Rebecca Turk-MacLeod, Margaret Mullin, Cole Mathis, Sara I. Walker, Leroy Cronin
      Pages: 5387 - 5392
      Abstract: Many approaches to the origin of life focus on how the molecules found in biology might be made in the absence of biological processes, from the simplest plausible starting materials. Another approach could be to view the emergence of the chemistry of biology as process whereby the environment effectively directs...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1813987116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Jet stream dynamics, hydroclimate, and fire in California from 1600 CE to
           present [Environmental Sciences]
    • Authors: Eugene R. Wahl; Eduardo Zorita, Valerie Trouet, Alan H. Taylor
      Pages: 5393 - 5398
      Abstract: Moisture delivery in California is largely regulated by the strength and position of the North Pacific jet stream (NPJ), winter high-altitude winds that influence regional hydroclimate and forest fire during the following warm season. We use climate model simulations and paleoclimate data to reconstruct winter NPJ characteristics back to 1571...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815292116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Renal reabsorption in 3D vascularized proximal tubule models [Engineering]
    • Authors: Neil Y. C. Lin; Kimberly A. Homan, Sanlin S. Robinson, David B. Kolesky, Nathan Duarte, Annie Moisan, Jennifer A. Lewis
      Pages: 5399 - 5404
      Abstract: Three-dimensional renal tissues that emulate the cellular composition, geometry, and function of native kidney tissue would enable fundamental studies of filtration and reabsorption. Here, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lined with confluent epithelium and endothelium, embedded in a permeable ECM, and...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815208116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Physical immobilization of particles inspired by pollination [Engineering]
    • Authors: Lucia F. Santos; A. Sofia Silva, Clara R. Correia, Joao F. Mano
      Pages: 5405 - 5410
      Abstract: Biomimetic systems often exhibit striking designs well adapted to specific functions that have been inspiring the development of new technologies. Herein, we explored the remarkable ability of honey bees to catch and release large quantities of pollen grains. Hair spacing and height on bees are crucial for their ability to...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1813336116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Interactive programming paradigm for real-time experimentation with remote
           living matter [Engineering]
    • Authors: Peter Washington; Karina G. Samuel-Gama, Shirish Goyal, Ashwin Ramaswami, Ingmar H. Riedel-Kruse
      Pages: 5411 - 5419
      Abstract: Recent advancements in life-science instrumentation and automation enable entirely new modes of human interaction with microbiological processes and corresponding applications for science and education through biology cloud laboratories. A critical barrier for remote and on-site life-science experimentation (for both experts and nonexperts alike) is the absence of suitable abstractions and...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815367116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Assessment of extreme heat and hospitalizations to inform early warning
           systems [Environmental Sciences]
    • Authors: Ambarish Vaidyanathan; Shubhayu Saha, Ana M. Vicedo-Cabrera, Antonio Gasparrini, Nabill Abdurehman, Richard Jordan, Michelle Hawkins, Jeremy Hess, Anne Elixhauser
      Pages: 5420 - 5427
      Abstract: Heat early warning systems and action plans use temperature thresholds to trigger warnings and risk communication. In this study, we conduct multistate analyses, exploring associations between heat and all-cause and cause-specific hospitalizations, to inform the design and development of heat–health early warning systems. We used a two-stage analysis to estimate...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1806393116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Almost partition identities [Mathematics]
    • Authors: George E. Andrews; Cristina Ballantine
      Pages: 5428 - 5436
      Abstract: An almost partition identity is an identity for partition numbers that is true asymptotically 100% of the time and fails infinitely often. We prove a kind of almost partition identity, namely that the number of parts in all self-conjugate partitions of n is almost always equal to the number of...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1820945116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Identifying spinon excitations from dynamic structure factor of spin-1/2
           Heisenberg antiferromagnet on the Kagome lattice [Physics]
    • Authors: W. Zhu; Shou-shu Gong, D. N. Sheng
      Pages: 5437 - 5441
      Abstract: A spin-1/2 lattice Heisenberg Kagome antiferromagnet (KAFM) is a prototypical frustrated quantum magnet, which exhibits exotic quantum spin liquids that evade long-range magnetic order due to the interplay between quantum fluctuation and geometric frustration. So far, the main focus has remained on the ground-state properties; however, the theoretical consensus regarding...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1807840116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Assembling responsive microgels at responsive lipid membranes [Physics]
    • Authors: Meina Wang; Adriana M. Mihut, Ellen Rieloff, Aleksandra P. Dabkowska, Linda K. Mansson, Jasper N. Immink, Emma Sparr, Jerome J. Crassous
      Pages: 5442 - 5450
      Abstract: Directed colloidal self-assembly at fluid interfaces can have a large impact in the fields of nanotechnology, materials, and biomedical sciences. The ability to control interfacial self-assembly relies on the fine interplay between bulk and surface interactions. Here, we investigate the interfacial assembly of thermoresponsive microgels and lipogels at the surface...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1807790116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Optimal errors and phase transitions in high-dimensional generalized
           linear models [Statistics]
    • Authors: Jean Barbier; Florent Krzakala, Nicolas Macris, Leo Miolane, Lenka Zdeborova
      Pages: 5451 - 5460
      Abstract: Generalized linear models (GLMs) are used in high-dimensional machine learning, statistics, communications, and signal processing. In this paper we analyze GLMs when the data matrix is random, as relevant in problems such as compressed sensing, error-correcting codes, or benchmark models in neural networks. We evaluate the mutual information (or “free...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1802705116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Fecal stanols show simultaneous flooding and seasonal precipitation change
           correlate with Cahokia’s population decline [Anthropology]
    • Authors: A.J. White; Lora R. Stevens, Varenka Lorenzi, Samuel E. Munoz, Sissel Schroeder, Angelica Cao, Taylor Bogdanovich
      Pages: 5461 - 5466
      Abstract: A number of competing hypotheses, including hydroclimatic variations, environmental degradation and disturbance, and sociopolitical disintegration, have emerged to explain the dissolution of Cahokia, the largest prehistoric population center in the United States. Because it is likely that Cahokia’s decline was precipitated by multiple factors, some environmental and some societal, a...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1809400116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Effect of oil spills on infant mortality in Nigeria [Sustainability
           Science]
    • Authors: Anna Bruederle; Roland Hodler
      Pages: 5467 - 5471
      Abstract: Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare siblings...
      Keywords: Sustainability Science
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818303116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Large-scale analysis of test-retest reliabilities of self-regulation
           measures [Psychological and Cognitive Sciences]
    • Authors: A. Zeynep Enkavi; Ian W. Eisenberg, Patrick G. Bissett, Gina L. Mazza, David P. MacKinnon, Lisa A. Marsch, Russell A. Poldrack
      Pages: 5472 - 5477
      Abstract: The ability to regulate behavior in service of long-term goals is a widely studied psychological construct known as self-regulation. This wide interest is in part due to the putative relations between self-regulation and a range of real-world behaviors. Self-regulation is generally viewed as a trait, and individual differences are quantified...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818430116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Advantaged socioeconomic conditions in childhood are associated with
           higher cognitive functioning but stronger cognitive decline in older age
           [Psychological and Cognitive Sciences]
    • Authors: Marȷa J. Aartsen; Boris Cheval, Stefan Sieber, Bernadette W. Van der Linden, Rainer Gabriel, Delphine S. Courvoisier, Idris Guessous, Claudine Burton–Jeangros, David Blane, Andreas Ihle, Matthias Kliegel, Stephane Cullati
      Pages: 5478 - 5486
      Abstract: Cognitive aging is characterized by large heterogeneity, which may be due to variations in childhood socioeconomic conditions (CSC). Although there is substantial evidence for an effect of CSC on levels of cognitive functioning at older age, results on associations with cognitive decline are mixed. We examined by means of an...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1807679116
      Issue No: Vol. 116, No. 12 (2019)
       
  • HDAC11 regulates type I interferon signaling through defatty-acylation of
           SHMT2 [Biochemistry]
    • Authors: Ji Cao; Lei Sun, Pornpun Aramsangtienchai, Nicole A. Spiegelman, Xiaoyu Zhang, Weishan Huang, Edward Seto, Hening Lin
      Pages: 5487 - 5492
      Abstract: The smallest histone deacetylase (HDAC) and the only class IV HDAC member, HDAC11, is reported to regulate immune activation and tumorigenesis, yet its biochemical function is largely unknown. Here we identify HDAC11 as an efficient lysine defatty-acylase that is>10,000-fold more efficient than its deacetylase activity. Through proteomics studies, we...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815365116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Cryo-electron microscopy structure of the filamentous bacteriophage IKe
           [Biochemistry]
    • Authors: Jingwei Xu; Nir Dayan, Amir Goldbourt, Ye Xiang
      Pages: 5493 - 5498
      Abstract: The filamentous bacteriophage IKe infects Escherichia coli cells bearing IncN pili. We report the cryo-electron microscopy structure of the micrometer-long IKe viral particle at a resolution of 3.4 Å. The major coat protein [protein 8 (p8)] consists of 47 residues that fold into a ∼68-Å-long helix. An atomic model of...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1811929116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Genome mining and biosynthesis of a polyketide from a biofertilizer fungus
           that can facilitate reductive iron assimilation in plant [Biochemistry]
    • Authors: Mengbin Chen; Qikun Liu, Shu-Shan Gao, Abbegayle E. Young, Steven E. Jacobsen, Yi Tang
      Pages: 5499 - 5504
      Abstract: Fungi have the potential to produce a large repertoire of bioactive molecules, many of which can affect the growth and development of plants. Genomic survey of sequenced biofertilizer fungi showed many secondary metabolite gene clusters are anchored by iterative polyketide synthases (IPKSs), which are multidomain enzymes noted for generating diverse...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819998116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Stepwise 5' DNA end-specific resection of DNA breaks by the
           Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble [Biochemistry]
    • Authors: Elda Cannavo; Giordano Reginato, Petr Cejka
      Pages: 5505 - 5513
      Abstract: To repair DNA double-strand breaks by homologous recombination, the 5′-terminated DNA strands must first be resected to produce 3′ overhangs. Mre11 from Saccharomyces cerevisiae is a 3′ → 5′ exonuclease that is responsible for 5′ end degradation in vivo. Using plasmid-length DNA substrates and purified recombinant proteins, we show that...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1820157116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Interleukin-37 monomer is the active form for reducing innate immunity
           [Biochemistry]
    • Authors: Elan Z. Eisenmesser; Adrian Gottschlich, Jasmina S. Redzic, Natasia Paukovich, Jay C. Nix, Tania Azam, Lingdi Zhang, Rui Zhao, Jeffrey S. Kieft, Erlinda The, Xianzhong Meng, Charles A. Dinarello
      Pages: 5514 - 5522
      Abstract: Interleukin-37 (IL-37), a member of the IL-1 family of cytokines, is a fundamental suppressor of innate and acquired immunities. Here, we used an integrative approach that combines biophysical, biochemical, and biological studies to elucidate the unique characteristics of IL-37. Our studies reveal that single amino acid mutations at the IL-37...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819672116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Domain topology, stability, and translation speed determine mechanical
           force generation on the ribosome [Biophysics and Computational Biology]
    • Authors: Sarah E. Leininger; Fabio Trovato, Daniel A. Nissley, Edward P. O’Brien
      Pages: 5523 - 5532
      Abstract: The concomitant folding of a nascent protein domain with its synthesis can generate mechanical forces that act on the ribosome and alter translation speed. Such changes in speed can affect the structure and function of the newly synthesized protein as well as cellular phenotype. The domain properties that govern force...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1813003116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Spastin is a dual-function enzyme that severs microtubules and promotes
           their regrowth to increase the number and mass of microtubules [Biophysics
           and Computational Biology]
    • Authors: Yin-Wei Kuo; Olivier Trottier, Mohammed Mahamdeh, Jonathon Howard
      Pages: 5533 - 5541
      Abstract: The remodeling of the microtubule cytoskeleton underlies dynamic cellular processes, such as mitosis, ciliogenesis, and neuronal morphogenesis. An important class of microtubule remodelers comprises the severases—spastin, katanin, and fidgetin—which cut microtubules into shorter fragments. While severing activity might be expected to break down the microtubule cytoskeleton, inhibiting these enzymes in...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818824116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Evolutionarily informed deep learning methods for predicting relative
           transcript abundance from DNA sequence [Biophysics and Computational
           Biology]
    • Authors: Jacob D. Washburn; Maria Katherine Mejia-Guerra, Guillaume Ramstein, Karl A. Kremling, Ravi Valluru, Edward S. Buckler, Hai Wang
      Pages: 5542 - 5549
      Abstract: Deep learning methodologies have revolutionized prediction in many fields and show potential to do the same in molecular biology and genetics. However, applying these methods in their current forms ignores evolutionary dependencies within biological systems and can result in false positives and spurious conclusions. We developed two approaches that account...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814551116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Motional dynamics of single Patched1 molecules in cilia are controlled by
           Hedgehog and cholesterol [Cell Biology]
    • Authors: Lucien E. Weiss; Ljiljana Milenkovic, Joshua Yoon, Tim Stearns, W. E. Moerner
      Pages: 5550 - 5557
      Abstract: The Hedgehog-signaling pathway is an important target in cancer research and regenerative medicine; yet, on the cellular level, many steps are still poorly understood. Extensive studies of the bulk behavior of the key proteins in the pathway established that during signal transduction they dynamically localize in primary cilia, antenna-like solitary...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1816747116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Double-negative T cells remarkably promote neuroinflammation after
           ischemic stroke [Cell Biology]
    • Authors: Hailan Meng; Haoran Zhao, Xiang Cao, Junwei Hao, He Zhang, Yi Liu, Min-sheng Zhu, Lizhen Fan, Leihua Weng, Lai Qian, Xiaoying Wang, Yun Xu
      Pages: 5558 - 5563
      Abstract: CD3+CD4−CD8− T cells (double-negative T cells; DNTs) have diverse functions in peripheral immune-related diseases by regulating immunological and inflammatory homeostasis. However, the functions of DNTs in the central nervous system remain unknown. Here, we found that the levels of DNTs were dramatically increased in both the brain and peripheral blood...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814394116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Infection by the parasitic helminth Trichinella spiralis activates a
           Tas2r-mediated signaling pathway in intestinal tuft cells [Cell Biology]
    • Authors: Xiao-Cui Luo; Zhen-Huang Chen, Jian-Bo Xue, Dong-Xiao Zhao, Chen Lu, Yi-Hong Li, Song-Min Li, Ya-Wen Du, Qun Liu, Ping Wang, Mingyuan Liu, Liquan Huang
      Pages: 5564 - 5569
      Abstract: The parasitic helminth Trichinella spiralis, which poses a serious health risk to animals and humans, can be found worldwide. Recent findings indicate that a rare type of gut epithelial cell, tuft cells, can detect the helminth, triggering type 2 immune responses. However, the underlying molecular mechanisms remain to be fully...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1812901116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Neural crest-derived neurons invade the ovary but not the testis during
           mouse gonad development [Developmental Biology]
    • Authors: Jennifer McKey; Corey Bunce, Iordan S. Batchvarov, David M. Ornitz, Blanche Capel
      Pages: 5570 - 5575
      Abstract: Testes and ovaries undergo sex-specific morphogenetic changes and adopt strikingly different morphologies, despite the fact that both arise from a common precursor, the bipotential gonad. Previous studies showed that recruitment of vasculature is critical for testis patterning. However, vasculature is not recruited into the early ovary. Peripheral innervation is involved...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814930116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Seedling traits predict drought-induced mortality linked to diversity loss
           [Ecology]
    • Authors: Susan Harrison; Marina LaForgia
      Pages: 5576 - 5581
      Abstract: Trait-based approaches are increasingly used to predict ecological consequences of climate change, yet seldom have solid links been established between plant traits and observed climate-driven community changes. Most analyses have focused on aboveground adult plant traits, but in warming and drying climates, root traits may be critical, and seedlings may...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818543116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Memory and resource tracking drive blue whale migrations [Ecology]
    • Authors: Briana Abrahms; Elliott L. Hazen, Ellen O. Aikens, Matthew S. Savoca, Jeremy A. Goldbogen, Steven J. Bograd, Michael G. Jacox, Ladd M. Irvine, Daniel M. Palacios, Bruce R. Mate
      Pages: 5582 - 5587
      Abstract: In terrestrial systems, the green wave hypothesis posits that migrating animals can enhance foraging opportunities by tracking phenological variation in high-quality forage across space (i.e., “resource waves”). To track resource waves, animals may rely on proximate cues and/or memory of long-term average phenologies. Although there is growing evidence of resource...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819031116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Narrow safety margin in the phyllosphere during thermal extremes [Ecology]
    • Authors: Sylvain Pincebourde; Jerome Casas
      Pages: 5588 - 5596
      Abstract: The thermal limit of ectotherms provides an estimate of vulnerability to climate change. It differs between contrasting microhabitats, consistent with thermal ecology predictions that a species’ temperature sensitivity matches the microclimate it experiences. However, observed thermal limits may differ between ectotherms from the same environment, challenging this theory. We resolved...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815828116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Oxytocin/vasopressin-like peptide inotocin regulates cuticular hydrocarbon
           synthesis and water balancing in ants [Ecology]
    • Authors: Akiko Koto; Naoto Motoyama, Hiroki Tahara, Sean McGregor, Minoru Moriyama, Takayoshi Okabe, Masayuki Miura, Laurent Keller
      Pages: 5597 - 5606
      Abstract: Oxytocin/vasopressin-like peptides are important regulators of physiology and social behavior in vertebrates. However, the function of inotocin, the homologous peptide in arthropods, remains largely unknown. Here, we show that the level of expression of inotocin and inotocin receptor are correlated with task allocation in the ant Camponotus fellah. Both genes...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1817788116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Evolution of nitric oxide regulation of gut function [Evolution]
    • Authors: Junko Yaguchi; Shunsuke Yaguchi
      Pages: 5607 - 5612
      Abstract: Although morphologies are diverse, the common pattern in bilaterians is for passage of food in the gut to be controlled by nerves and endodermally derived neuron-like cells. In vertebrates, nitric oxide (NO) derived from enteric nerves controls relaxation of the pyloric sphincter. Here, we show that in the larvae of...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1816973116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Environment-dependent fitness gains can be driven by horizontal gene
           transfer of transporter-encoding genes [Evolution]
    • Authors: David S. Milner; Victoria Attah, Emily Cook, Finlay Maguire, Fiona R. Savory, Mark Morrison, Carolin A. Muller, Peter G. Foster, Nicholas J. Talbot, Guy Leonard, Thomas A. Richards
      Pages: 5613 - 5622
      Abstract: Many microbes acquire metabolites in a “feeding” process where complex polymers are broken down in the environment to their subunits. The subsequent uptake of soluble metabolites by a cell, sometimes called osmotrophy, is facilitated by transporter proteins. As such, the diversification of osmotrophic microorganisms is closely tied to the diversification...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815994116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Weevil pgrp-lb prevents endosymbiont TCT dissemination and chronic host
           systemic immune activation [Evolution]
    • Authors: Justin Maire; Carole Vincent–Monegat, Severine Balmand, Agnes Vallier, Mireille Herve, Florent Masson, Nicolas Parisot, Aurelien Vigneron, Caroline Anselme, Jackie Perrin, Julien Orlans, Isabelle Rahioui, Pedro Da Silva, Marie–Odile Fauvarque, Dominique Mengin–Lecreulx, Anna Zaidman–Remy, Abdelaziz Heddi
      Pages: 5623 - 5632
      Abstract: Long-term intracellular symbiosis (or endosymbiosis) is widely distributed across invertebrates and is recognized as a major driving force in evolution. However, the maintenance of immune homeostasis in organisms chronically infected with mutualistic bacteria is a challenging task, and little is known about the molecular processes that limit endosymbiont immunogenicity and...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1821806116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Regulatory changes in pterin and carotenoid genes underlie balanced color
           polymorphisms in the wall lizard [Evolution]
    • Authors: Pedro Andrade; Catarina Pinho, Guillem Perez i de Lanuza, Sandra Afonso, Jindřich Breȷcha, Carl–Johan Rubin, Ola Wallerman, Paulo Pereira, Stephen J. Sabatino, Adriana Bellati, Daniele Pellitteri–Rosa, Zuzana Bosakova, Ignas Bunikis, Miguel A. Carretero, Nathalie Feiner, Petr Marsik, Francisco Pauperio, Daniele Salvi, Lucile Soler, Geoffrey M. While, Tobias Uller, Enrique Font, Leif Andersson, Miguel Carneiro
      Pages: 5633 - 5642
      Abstract: Reptiles use pterin and carotenoid pigments to produce yellow, orange, and red colors. These conspicuous colors serve a diversity of signaling functions, but their molecular basis remains unresolved. Here, we show that the genomes of sympatric color morphs of the European common wall lizard (Podarcis muralis), which differ in orange...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1820320116
      Issue No: Vol. 116, No. 12 (2019)
       
  • The genetic architecture of teosinte catalyzed and constrained maize
           domestication [Evolution]
    • Authors: Chin Jian Yang; Luis Fernando Samayoa, Peter J. Bradbury, Bode A. Olukolu, Wei Xue, Alessandra M. York, Michael R. Tuholski, Weidong Wang, Lora L. Daskalska, Michael A. Neumeyer, Jose de Jesus Sanchez-Gonzalez, Maria Cinta Romay, Jeffrey C. Glaubitz, Qi Sun, Edward S. Buckler, James B. Holland, John F. Doebley
      Pages: 5643 - 5652
      Abstract: The process of evolution under domestication has been studied using phylogenetics, population genetics–genomics, quantitative trait locus (QTL) mapping, gene expression assays, and archaeology. Here, we apply an evolutionary quantitative genetic approach to understand the constraints imposed by the genetic architecture of trait variation in teosinte, the wild ancestor of maize,...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1820997116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Patterns of genome-wide allele-specific expression in hybrid rice and the
           implications on the genetic basis of heterosis [Genetics]
    • Authors: Lin Shao; Feng Xing, Conghao Xu, Qinghua Zhang, Jian Che, Xianmeng Wang, Jiaming Song, Xianghua Li, Jinghua Xiao, Ling-Ling Chen, Yidan Ouyang, Qifa Zhang
      Pages: 5653 - 5658
      Abstract: Utilization of heterosis has greatly increased the productivity of many crops worldwide. Although tremendous progress has been made in characterizing the genetic basis of heterosis using genomic technologies, molecular mechanisms underlying the genetic components are much less understood. Allele-specific expression (ASE), or imbalance between the expression levels of two parental...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1820513116
      Issue No: Vol. 116, No. 12 (2019)
       
  • A SIR-independent role for cohesin in subtelomeric silencing and
           organization [Genetics]
    • Authors: Deepash Kothiwal; Shikha Laloraya
      Pages: 5659 - 5664
      Abstract: Cohesin is a key determinant of chromosome architecture due to its DNA binding and tethering ability. Cohesin binds near centromeres and chromosome arms and also close to telomeres, but its role near telomeres remains elusive. In budding yeast, transcription within 20 kb of telomeres is repressed, in part by the...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1816582116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Chloroplast competition is controlled by lipid biosynthesis in evening
           primroses [Genetics]
    • Authors: Johanna Sobanski; Patrick Giavalisco, Axel Fischer, Julia M. Kreiner, Dirk Walther, Mark Aurel Schottler, Tommaso Pellizzer, Hieronim Golczyk, Toshihiro Obata, Ralph Bock, Barbara B. Sears, Stephan Greiner
      Pages: 5665 - 5674
      Abstract: In most eukaryotes, organellar genomes are transmitted preferentially by the mother, but molecular mechanisms and evolutionary forces underlying this fundamental biological principle are far from understood. It is believed that biparental inheritance promotes competition between the cytoplasmic organelles and allows the spread of so-called selfish cytoplasmic elements. Those can be,...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1811661116
      Issue No: Vol. 116, No. 12 (2019)
       
  • RIP1 kinase inhibitor halts the progression of an immune-induced
           demyelination disease at the stage of monocyte elevation [Immunology and
           Inflammation]
    • Authors: Sitao Zhang; Yaning Su, Zhengxin Ying, Dejia Guo, Chenjie Pan, Jia Guo, Ziye Zou, Lei Wang, Ze Zhang, Zhaodi Jiang, Zhiyuan Zhang, Xiaodong Wang
      Pages: 5675 - 5680
      Abstract: Demyelination in the central nervous system (CNS) underlies many human diseases, including multiple sclerosis (MS). We report here the findings of our study of the CNS demyelination process using immune-induced [experimental autoimmune encephalomyelitis (EAE)] and chemical-induced [cuprizone (CPZ)] mouse models of demyelination. We found that necroptosis, a receptor-interacting protein 3...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819917116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Renal control of disease tolerance to malaria [Immunology and
           Inflammation]
    • Authors: Susana Ramos; Ana Rita Carlos, Balamurugan Sundaram, Viktoria Jeney, Ana Ribeiro, Raffaella Gozzelino, Claudia Bank, Erida Gȷini, Faouzi Braza, Rui Martins, Temitope Wilson Ademolue, Birte Blankenhaus, Zelia Gouveia, Pedro Faisca, Damian Truȷillo, Silvia Cardoso, Sofia Rebelo, Laura del Barrio, Abolfazl Zarȷou, Subhashini Bolisetty, Anupam Agarwal, Miguel P. Soares
      Pages: 5681 - 5686
      Abstract: Malaria, the disease caused by Plasmodium spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on immune-driven resistance mechanisms that kill Plasmodium. However, these mechanisms are not sufficient per se to avoid the development of severe forms of disease. This is accomplished instead...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1822024116
      Issue No: Vol. 116, No. 12 (2019)
       
  • MDA-7/IL-24 regulates the miRNA processing enzyme DICER through
           downregulation of MITF [Medical Sciences]
    • Authors: Anjan K. Pradhan; Praveen Bhoopathi, Sarmistha Talukdar, Danielle Scheunemann, Devanand Sarkar, Webster K. Cavenee, Swadesh K. Das, Luni Emdad, Paul B. Fisher
      Pages: 5687 - 5692
      Abstract: Melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) is a multifunctional cytokine displaying broad-spectrum anticancer activity in vitro or in vivo in preclinical animal cancer models and in a phase 1/2 clinical trial in patients with advanced cancers. mda-7/IL-24 targets specific miRNAs, including miR-221 and miR-320, for down-regulation in a cancer-selective manner. We demonstrate...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819869116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Human cytomegalovirus haplotype reconstruction reveals high diversity due
           to superinfection and evidence of within-host recombination [Microbiology]
           
    • Authors: Juliana Cudini; Sunando Roy, Charlotte J. Houldcroft, Josephine M. Bryant, Daniel P. Depledge, Helena Tutill, Paul Veys, Rachel Williams, Austen J. J. Worth, Asif U. Tamuri, Richard A. Goldstein, Judith Breuer
      Pages: 5693 - 5698
      Abstract: Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV) genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, Bhattacharjee B, Jensen JD, Gibson L, Kowalik TF (2011) PLoS Pathog 7:e1001344]. Here, we deep sequence HCMV genomes recovered from single and longitudinally collected blood samples from...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1818130116
      Issue No: Vol. 116, No. 12 (2019)
       
  • NF-{kappa}B activation is a turn on for vaccinia virus phosphoprotein A49
           to turn off NF-{kappa}B activation [Microbiology]
    • Authors: Sarah Neidel; Hongwei Ren, Alice A. Torres, Geoffrey L. Smith
      Pages: 5699 - 5704
      Abstract: Vaccinia virus protein A49 inhibits NF-κB activation by molecular mimicry and has a motif near the N terminus that is conserved in IκBα, β-catenin, HIV Vpu, and some other proteins. This motif contains two serines, and for IκBα and β-catenin, phosphorylation of these serines enables recognition by the E3 ubiquitin...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1813504116
      Issue No: Vol. 116, No. 12 (2019)
       
  • TIM-mediated inhibition of HIV-1 release is antagonized by Nef but
           potentiated by SERINC proteins [Microbiology]
    • Authors: Minghua Li; Abdul A. Waheed, Jingyou Yu, Cong Zeng, Hui–Yu Chen, Yi–Min Zheng, Amin Feizpour, Bȷorn M. Reinhard, Suryaram Gummuluru, Steven Lin, Eric O. Freed, Shan–Lu Liu
      Pages: 5705 - 5714
      Abstract: The T cell Ig and mucin domain (TIM) proteins inhibit release of HIV-1 and other enveloped viruses by interacting with cell- and virion-associated phosphatidylserine (PS). Here, we show that the Nef proteins of HIV-1 and other lentiviruses antagonize TIM-mediated restriction. TIM-1 more potently inhibits the release of Nef-deficient relative to...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1819475116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Activity-dependent visualization and control of neural circuits for
           courtship behavior in the fly Drosophila melanogaster [Neuroscience]
    • Authors: Seika Takayanagi-Kiya; Taketoshi Kiya
      Pages: 5715 - 5720
      Abstract: Males of Drosophila melanogaster exhibit stereotypic courtship behavior through which they assess potential mates by processing multimodal sensory information. Although previous studies revealed important neural circuits involved in this process, the full picture of circuits that participate in male courtship remains elusive. Here, we established a genetic tool to visualize...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814628116
      Issue No: Vol. 116, No. 12 (2019)
       
  • PERIOD-controlled deadenylation of the timeless transcript in the
           Drosophila circadian clock [Neuroscience]
    • Authors: Brigitte Grima; Christian Papin, Beatrice Martin, Elisabeth Chelot, Prishila Ponien, Eric Jacquet, Francois Rouyer
      Pages: 5721 - 5726
      Abstract: The Drosophila circadian oscillator relies on a negative transcriptional feedback loop, in which the PERIOD (PER) and TIMELESS (TIM) proteins repress the expression of their own gene by inhibiting the activity of the CLOCK (CLK) and CYCLE (CYC) transcription factors. A series of posttranslational modifications contribute to the oscillations of...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1814418116
      Issue No: Vol. 116, No. 12 (2019)
       
  • MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in
           hippocampal neurons [Neuroscience]
    • Authors: Mariline M. Silva; Beatriz Rodrigues, Joana Fernandes, Sandra D. Santos, Laura Carreto, Manuel A. S. Santos, Paulo Pinheiro, Ana Luisa Carvalho
      Pages: 5727 - 5736
      Abstract: Homeostatic synaptic scaling is a negative feedback response to fluctuations in synaptic strength induced by developmental or learning-related processes, which maintains neuronal activity stable. Although several components of the synaptic scaling apparatus have been characterized, the intrinsic regulatory mechanisms promoting scaling remain largely unknown. MicroRNAs may contribute to posttranscriptional control...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1900338116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Long-term population spike-timing-dependent plasticity promotes synaptic
           tagging but not cross-tagging in rat hippocampal area CA1 [Neuroscience]
    • Authors: Karen Ka Lam Pang, Mahima Sharma, Kumar Krishna-K; Thomas Behnisch, Sreedharan Sajikumar
      Pages: 5737 - 5746
      Abstract: In spike-timing-dependent plasticity (STDP), the direction and degree of synaptic modification are determined by the coherence of pre- and postsynaptic activities within a neuron. However, in the adult rat hippocampus, it remains unclear whether STDP-like mechanisms in a neuronal population induce synaptic potentiation of a long duration. Thus, we asked...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1817643116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Transcranial alternating current stimulation entrains single-neuron
           activity in the primate brain [Neuroscience]
    • Authors: Matthew R. Krause; Pedro G. Vieira, Bennett A. Csorba, Praveen K. Pilly, Christopher C. Pack
      Pages: 5747 - 5755
      Abstract: Spike timing is thought to play a critical role in neural computation and communication. Methods for adjusting spike timing are therefore of great interest to researchers and clinicians alike. Transcranial electrical stimulation (tES) is a noninvasive technique that uses weak electric fields to manipulate brain activity. Early results have suggested...
      PubDate: 2019-03-19T10:36:51-07:00
      DOI: 10.1073/pnas.1815958116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Control of hearing sensitivity by tectorial membrane calcium
           [Neuroscience]
    • Authors: Clark Elliott Strimbu; Sonal Prasad, Pierre Hakizimana, Anders Fridberger
      Pages: 5756 - 5764
      Abstract: When sound stimulates the stereocilia on the sensory cells in the hearing organ, Ca2+ ions flow through mechanically gated ion channels. This Ca2+ influx is thought to be important for ensuring that the mechanically gated channels operate within their most sensitive response region, setting the fraction of channels open at...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1805223116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau
           neuropathology and dopaminergic neurodegeneration [Neuroscience]
    • Authors: Xi Chen; Jennifer K. Kordich, Erin T. Williams, Nathan Levine, Allyson Cole-Strauss, Lee Marshall, Viviane Labrie, Jiyan Ma, Jack W. Lipton, Darren J. Moore
      Pages: 5765 - 5774
      Abstract: Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene represent a cause of late-onset, autosomal dominant familial Parkinson’s disease (PD). A single missense mutation, D620N, is considered pathogenic based upon its segregation with disease in multiple families with PD. At present, the mechanism(s) by which familial VPS35 mutations precipitate...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1814909116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Lipid transporter TMEM24/C2CD2L is a Ca2+-regulated component of ER-plasma
           membrane contacts in mammalian neurons [Neuroscience]
    • Authors: Elizabeth Wen Sun; Andres Guillen–Samander, Xin Bian, Yumei Wu, Yiying Cai, Mirko Messa, Pietro De Camilli
      Pages: 5775 - 5784
      Abstract: Close appositions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are a general feature of all cells and are abundant in neurons. A function of these appositions is lipid transport between the two adjacent bilayers via tethering proteins that also contain lipid transport modules. However, little is known...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1820156116
      Issue No: Vol. 116, No. 12 (2019)
       
  • AAV cis-regulatory sequences are correlated with ocular toxicity
           [Neuroscience]
    • Authors: Wenjun Xiong; David M. Wu, Yunlu Xue, Sean K. Wang, Michelle J. Chung, Xuke Ji, Parimal Rana, Sophia R. Zhao, Shuyi Mai, Constance L. Cepko
      Pages: 5785 - 5794
      Abstract: Adeno-associated viral vectors (AAVs) have become popular for gene therapy, given their many advantages, including their reduced inflammatory profile compared with that of other viruses. However, even in areas of immune privilege such as the eye, AAV vectors are capable of eliciting host-cell responses. To investigate the effects of such...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1821000116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Constitutive signaling activity of a receptor-associated protein links
           fertilization with embryonic patterning in Arabidopsis thaliana [Plant
           Biology]
    • Authors: Ancilla Neu; Emily Eilbert, Lisa Y. Asseck, Daniel Slane, Agnes Henschen, Kai Wang, Patrick Burgel, Melanie Hildebrandt, Thomas J. Musielak, Martina Kolb, Wolfgang Lukowitz, Christopher Grefen, Martin Bayer
      Pages: 5795 - 5804
      Abstract: In flowering plants, the asymmetrical division of the zygote is the first hallmark of apical-basal polarity of the embryo and is controlled by a MAP kinase pathway that includes the MAPKKK YODA (YDA). In Arabidopsis, YDA is activated by the membrane-associated pseudokinase SHORT SUSPENSOR (SSP) through an unusual parent-of-origin effect:...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1815866116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Symbolic labeling in 5-month-old human infants [Psychological and
           Cognitive Sciences]
    • Authors: Claire Kabdebon; Ghislaine Dehaene-Lambertz
      Pages: 5805 - 5810
      Abstract: Humans’ ability to create and manipulate symbolic structures far exceeds that of other animals. We hypothesized that this ability rests on an early capacity to use arbitrary signs to represent any mental representation, even as abstract as an algebraic rule. In three experiments, we collected high-density EEG recordings while 150...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1809144116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Task-driven visual exploration at the foveal scale [Psychological and
           Cognitive Sciences]
    • Authors: Natalya Shelchkova; Christie Tang, Martina Poletti
      Pages: 5811 - 5818
      Abstract: Humans use saccades to inspect objects of interest with the foveola, the small region of the retina with highest acuity. This process of visual exploration is normally studied over large scenes. However, in everyday tasks, the stimulus within the foveola is complex, and the need for visual exploration may extend...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1812222116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Genomic and molecular characterization of preterm birth [Systems Biology]
    • Authors: Theo A. Knijnenburg; Joseph G. Vockley, Nyasha Chambwe, David L. Gibbs, Crystal Humphries, Kathi C. Huddleston, Elisabeth Klein, Prachi Kothiyal, Ryan Tasseff, Varsha Dhankani, Dale L. Bodian, Wendy S. W. Wong, Gustavo Glusman, Denise E. Mauldin, Michael Miller, Joseph Slagel, Summer Elasady, Jared C. Roach, Roger Kramer, Kalle Leinonen, Jasper Linthorst, Rajiv Baveja, Robin Baker, Benjamin D. Solomon, Greg Eley, Ramaswamy K. Iyer, George L. Maxwell, Brady Bernard, Ilya Shmulevich, Leroy Hood, John E. Niederhuber
      Pages: 5819 - 5827
      Abstract: Preterm birth (PTB) complications are the leading cause of long-term morbidity and mortality in children. By using whole blood samples, we integrated whole-genome sequencing (WGS), RNA sequencing (RNA-seq), and DNA methylation data for 270 PTB and 521 control families. We analyzed this combined dataset to identify genomic variants associated with...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1716314116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Correction for Shneiderman, Creativity and collaboration: Revisiting
           cybernetic serendipity [Correction]
    • Pages: 5828 - 5828
      Abstract: COLLOQUIUM Correction for “Creativity and collaboration: Revisiting cybernetic serendipity,” by Ben Shneiderman, which was first published February 5, 2019; 10.1073/pnas.1807200116 (Proc Natl Acad Sci USA 116:1837–1843). The author notes that, on page 1840, left column, second full paragraph, lines 4–5, Jeffrey Heer should have been included in the list of...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1902578116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Correction for Li et al., Mutational landscape of primary, metastatic, and
           recurrent ovarian cancer reveals c-MYC gains as potential target for BET
           inhibitors [Correction]
    • Pages: 5829 - 5829
      Abstract: MEDICAL SCIENCES Correction for “Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors,” by Charles Li, Elena Bonazzoli, Stefania Bellone, Jungmin Choi, Weilai Dong, Gulden Menderes, Gary Altwerger, Chanhee Han, Aranzazu Manzano, Anna Bianchi, Francesca Pettinella, Paola Manara, Salvatore Lopez, Ghanshyam...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1902633116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Correction for Moore et al., Robust predictions of specialized metabolism
           genes through machine learning [Correction]
    • Pages: 5830 - 5830
      Abstract: PLANT BIOLOGY Correction for “Robust predictions of specialized metabolism genes through machine learning,” by Bethany M. Moore, Peipei Wang, Pengxiang Fan, Bryan Leong, Craig A. Schenck, John P. Lloyd, Melissa D. Lehti-Shiu, Robert L. Last, Eran Pichersky, and Shin-Han Shiu, which was first published February 5, 2019; 10.1073/pnas.1817074116 (Proc Natl...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1902386116
      Issue No: Vol. 116, No. 12 (2019)
       
  • Correction to Supporting Information for Townsend et al., Dietary sugar
           silences a colonization factor in a mammalian gut symbiont [SI Correction]
           
    • Pages: 5831 - 5831
      Abstract: MICROBIOLOGY Correction to Supporting Information for “Dietary sugar silences a colonization factor in a mammalian gut symbiont,” by Guy E. Townsend II, Weiwei Han, Nathan D. Schwalm III, Varsha Raghavan, Natasha A. Barry, Andrew L. Goodman, and Eduardo A. Groisman, which was first published December 17, 2018; 10.1073/pnas.1813780115 (Proc Natl...
      PubDate: 2019-03-19T10:36:52-07:00
      DOI: 10.1073/pnas.1902700116
      Issue No: Vol. 116, No. 12 (2019)
       
 
 
JournalTOCs
School of Mathematical and Computer Sciences
Heriot-Watt University
Edinburgh, EH14 4AS, UK
Email: journaltocs@hw.ac.uk
Tel: +00 44 (0)131 4513762
Fax: +00 44 (0)131 4513327
 
Home (Search)
Subjects A-Z
Publishers A-Z
Customise
APIs
Your IP address: 34.229.97.16
 
About JournalTOCs
API
Help
News (blog, publications)
JournalTOCs on Twitter   JournalTOCs on Facebook

JournalTOCs © 2009-