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Proceedings of the National Academy of Sciences
Journal Prestige (SJR): 6.092
Citation Impact (citeScore): 9
Number of Followers: 1096  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 0027-8424 - ISSN (Online) 1091-6490
Published by PNAS Homepage  [1 journal]
  • In This Issue [This Week in PNAS]
    • Pages: 12113 - 12115
      Abstract: Synapse-boosting factors in young blood Young (15-day-old; Left) and aged (15-month-old; Right) mice used in the experiments. Cognitive aging is driven by changes in systemic factors circulating in blood, according to one hypothesis. Studies supporting this hypothesis have found that transfusing the blood of young mice into old mice—a process...
      Keywords: In This Issue
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/iti2519116
      Issue No: Vol. 116, No. 25 (2019)
       
  • News Feature: Probing the limits of “evolutionary rescue”
           [Evolution]
    • Authors: Amy McDermott
      Pages: 12116 - 12120
      Abstract: Could species threatened by climate change and other stresses avoid extinction through rapid evolution' In the space of five years, the field crickets of Kauai fell silent. The quiet was deafening to evolutionary biologist Marlene Zuk, who had spent a decade crawling through Hawaii's vacant lots and church lawns, collecting...
      Keywords: News Features, Front Matter
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1907565116
      Issue No: Vol. 116, No. 25 (2019)
       
  • QnAs with Mitchell A. Lazar [QnAs]
    • Authors: Sandeep Ravindran
      Pages: 12121 - 12122
      Abstract: Mitchell A. Lazar has spent his career studying the transcriptional regulation of metabolism, particularly the role of nuclear receptors. He has discovered several nuclear receptors and elucidated the mechanisms by which they interact with the genome and epigenome. He has made key findings related to the nuclear receptor PPARγ, including...
      Keywords: QnAs
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1907488116
      Issue No: Vol. 116, No. 25 (2019)
       
  • QnAs with Hidde L. Ploegh [QnAs]
    • Authors: Prashant Nair
      Pages: 12123 - 12125
      Abstract: Over the past decade, immunotherapy has been slowly transforming cancer treatment. Among the treatment approaches already in the clinic are checkpoint inhibitors, which are antibodies that unshackle patients’ own tumor-targeting immune cells, and chimeric antigen receptor T cells (CAR-T cells), which are genetically engineered T cells infused into patients to...
      Keywords: QnAs
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908701116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Profile of David D. Ginty [Profiles]
    • Authors: Sandeep Ravindran
      Pages: 12126 - 12128
      Abstract: The sense of touch is key to humans’ ability to experience the world, but unraveling the neural pathways underpinning this key sense has been a challenge. David D. Ginty has spent more than two decades investigating the development of the somatosensory system and fundamental mechanisms underlying the sense of touch....
      Keywords: PNAS Profiles
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908066116
      Issue No: Vol. 116, No. 25 (2019)
       
  • A different branch of the high Tc family' [Applied Physical Sciences]
    • Authors: D. J. Scalapino
      Pages: 12129 - 12130
      Abstract: In PNAS, Li et al. (1) suggest that Ba2CuO4−y is a member of a different branch of high-Tc cuprate superconducting materials. This branch is characterized as heavily overdoped with an exceptionally short Cu apical O spacing and O vacancies that are located in the CuO2 planes. These characteristics, illustrated in...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1907649116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Adaptation to diversity: Individual and societal processes [Social
           Sciences]
    • Authors: Linda R. Tropp
      Pages: 12131 - 12133
      Abstract: With the historic rise in global migration in recent decades and the dispersion of diverse groups into new communities worldwide, greater levels of contact are occurring between social groups than ever before. It is in this context that Ramos et al. (1) rightfully note the potential for humans to adapt...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1907380116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Valuing the Greenland ice sheet and other complex geophysical phenomena
           [Sustainability Science]
    • Authors: William A. Pizer
      Pages: 12134 - 12135
      Abstract: For the last 40 y, economists have worked to put monetary values on environmental amenities to facilitate the cost–benefit analysis (CBA) of alternative policies (1–3). The motivation is simple: Policy choices inevitably require trade-offs. Resources devoted to climate change mitigation are resources not spent on curing diseases, improving education, alleviating...
      Keywords: Sustainability Science
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1906927116
      Issue No: Vol. 116, No. 25 (2019)
       
  • How Chlamydia trachomatis conquered gut microbiome-derived antimicrobial
           compounds and found a new home in the eye [Microbiology]
    • Authors: Arkaprabha Banerjee; David E. Nelson
      Pages: 12136 - 12138
      Abstract: Different variants of the obligate intracellular bacterial pathogen Chlamydia trachomatis cause the diseases trachoma and chlamydia. The trachoma strains cause chronic infections of the conjunctival epithelium and an intense inflammatory response that can lead to corneal damage, and trachoma is the most common cause of infectious blindness. The Chlamydia strains...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1907647116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Misallocation of mycorrhizal traits leads to misleading results
           [Biological Sciences]
    • Authors: Leho Tedersoo; Saleh Rahimlou, Mark Brundrett
      Pages: 12139 - 12140
      Abstract: Based on a long-term field experiment involving 35 tree species, Sun et al. (1) suggest that mycorrhizal types of plants differ in decomposition rates of leaf litter, but not root litter. Although the authors refer to several publications regarding mycorrhizal status of plants and claim to have performed their own...
      Keywords: Letters
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1903178116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Reply to Tedersoo et al.: Plant species within the same family or genus
           can have different mycorrhizal types' [Biological Sciences]
    • Authors: Tao Sun; Hongguang Zhang, Zhengwen Wang
      Pages: 12141 - 12142
      Abstract: There are two main methods used to assign plant mycorrhizal type to plant species: empirical vs. phylogenetic–taxonomic (hereafter taxonomic) methods (1). The empirical method uses only available collated empirical data based on direct observation of mycorrhizal type, while the taxonomic approach extrapolates plant mycorrhizal traits to complete taxonomic groups, such...
      Keywords: Letters
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1903868116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Populations are not declining and food webs are not collapsing at the
           Luquillo Experimental Forest [Biological Sciences]
    • Authors: M. R. Willig; L. Woolbright, S. J. Presley, T. D. Schowalter, R. B. Waide, T. Heartsill Scalley, J. K. Zimmerman, G. Gonzalez, A. E. Lugo
      Pages: 12143 - 12144
      Abstract: In PNAS, Lister and Garcia (1) report declines in abundances of understory arthropods and lizards between 1976 and 2012 and claim similar declines in populations of arthropods, frogs, and insectivorous birds based on data from the Luquillo Long-Term Ecological Research project (LUQ). Their conclusion, that increasing temperature has led to...
      Keywords: Letters
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820456116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Reply to Willig et al.: Long-term population trends in the Luquillo
           Rainforest [Biological Sciences]
    • Authors: Brad Lister; Andres Garcia
      Pages: 12145 - 12146
      Abstract: Temperatures In our study (1), given Long-Term Ecological Research (LTER) information, we avoid data compromised by long-term averages and adjustments using data from other stations. Since temperatures for January 1975 to April 1978 include long-term averages, our data (1) begin in 1979. From 1979 on, we use temperatures corrected by...
      Keywords: Letters
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904582116
      Issue No: Vol. 116, No. 25 (2019)
       
  • SR9009 has REV-ERB-independent effects on cell proliferation and
           metabolism [Pharmacology]
    • Authors: Pieterjan Dierickx; Matthew J. Emmett, Chunjie Jiang, Kahealani Uehara, Manlu Liu, Marine Adlanmerini, Mitchell A. Lazar
      Pages: 12147 - 12152
      Abstract: The nuclear receptors REV-ERBα and -β link circadian rhythms and metabolism. Like other nuclear receptors, REV-ERB activity can be regulated by ligands, including naturally occurring heme. A putative ligand, SR9009, has been reported to elicit a range of beneficial effects in healthy as well as diseased animal models and cell...
      Keywords: Inaugural Articles
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904226116
      Issue No: Vol. 116, No. 25 (2019)
       
  • A bacterial isolate from the Black Sea oxidizes sulfide with manganese(IV)
           oxide [Microbiology]
    • Authors: Jan V. Henkel; Olaf Dellwig, Falk Pollehne, Daniel P. R. Herlemann, Thomas Leipe, Heide N. Schulz-Vogt
      Pages: 12153 - 12155
      Abstract: In stratified basins, for example the Black Sea, in between the oxygenated surface waters and sulfidic bottom waters a suboxic zone lacking oxygen (O2), H2S, and mostly also nitrate (NO3−) has been frequently reported (1). Despite the absence of electron acceptors, high bacterial CO2 fixation rates at the border with...
      Keywords: Brief Reports
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1906000116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Superconductivity in a unique type of copper oxide [Applied Physical
           Sciences]
    • Authors: W. M. Li; J. F. Zhao, L. P. Cao, Z. Hu, Q. Z. Huang, X. C. Wang, Y. Liu, G. Q. Zhao, J. Zhang, Q. Q. Liu, R. Z. Yu, Y. W. Long, H. Wu, H. J. Lin, C. T. Chen, Z. Li, Z. Z. Gong, Z. Guguchia, J. S. Kim, G. R. Stewart, Y. J. Uemura, S. Uchida, C. Q. Jin
      Pages: 12156 - 12160
      Abstract: The mechanism of superconductivity in cuprates remains one of the big challenges of condensed matter physics. High-Tc cuprates crystallize into a layered perovskite structure featuring copper oxygen octahedral coordination. Due to the Jahn Teller effect in combination with the strong static Coulomb interaction, the octahedra in high-Tc cuprates are elongated...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900908116
      Issue No: Vol. 116, No. 25 (2019)
       
  • The base pair-scale diffusion of nucleosomes modulates binding of
           transcription factors [Biochemistry]
    • Authors: Sergei Rudnizky; Hadeel Khamis, Omri Malik, Philippa Melamed, Ariel Kaplan
      Pages: 12161 - 12166
      Abstract: The structure of promoter chromatin determines the ability of transcription factors (TFs) to bind to DNA and therefore has a profound effect on the expression levels of genes. However, the role of spontaneous nucleosome movements in this process is not fully understood. Here, we developed a single-molecule optical tweezers assay...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1815424116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Ratiometric two-photon microscopy reveals attomolar copper buffering in
           normal and Menkes mutant cells [Biochemistry]
    • Authors: M. Thomas Morgan; Daisy Bourassa, Shefali Harankhedkar, Adam M. McCallum, Stephanie A. Zlatic, Jenifer S. Calvo, Gabriele Meloni, Victor Faundez, Christoph J. Fahrni
      Pages: 12167 - 12172
      Abstract: Copper is controlled by a sophisticated network of transport and storage proteins within mammalian cells, yet its uptake and efflux occur with rapid kinetics. Present as Cu(I) within the reducing intracellular environment, the nature of this labile copper pool remains elusive. While glutathione is involved in copper homeostasis and has...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900172116
      Issue No: Vol. 116, No. 25 (2019)
       
  • 2H/1H variation in microbial lipids is controlled by NADPH metabolism
           [Earth, Atmospheric, and Planetary Sciences]
    • Authors: Reto S. Wijker; Alex L. Sessions, Tobias Fuhrer, Michelle Phan
      Pages: 12173 - 12182
      Abstract: The hydrogen-isotopic compositions (2H/1H ratios) of lipids in microbial heterotrophs are known to vary enormously, by at least 40% (400‰) relative. This is particularly surprising, given that most C-bound H in their lipids appear to derive from the growth medium water, rather than from organic substrates, implying that the isotopic...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818372116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis
           [Engineering]
    • Authors: William A. Blessing; Stephen M. Okajima, M. Belen Cubria, Juan C. Villa-Camacho, Miguel Perez-Viloria, Patrick M. Williamson, Angie N. Sabogal, Sebastian Suarez, Lay-Hong Ang, Suzanne White, Evelyn Flynn, Edward K. Rodriguez, Mark W. Grinstaff, Ara Nazarian
      Pages: 12183 - 12192
      Abstract: Arthrofibrosis is a prevalent condition affecting greater than 5% of the general population and leads to a painful decrease in joint range of motion (ROM) and loss of independence due to pathologic accumulation of periarticular scar tissue. Current treatment options are limited in effectiveness and do not address the underlying...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900355116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Hydrodynamics control shear-induced pattern formation in attractive
           suspensions [Engineering]
    • Authors: Zsigmond Varga; Vincent Grenard, Stefano Pecorario, Nicolas Taberlet, Vincent Dolique, Sebastien Manneville, Thibaut Divoux, Gareth H. McKinley, James W. Swan
      Pages: 12193 - 12198
      Abstract: Dilute suspensions of repulsive particles exhibit a Newtonian response to flow that can be accurately predicted by the particle volume fraction and the viscosity of the suspending fluid. However, such a description fails when the particles are weakly attractive. In a simple shear flow, suspensions of attractive particles exhibit complex,...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901370116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Magnetic field-induced intermediate quantum spin liquid with a spinon
           Fermi surface [Physics]
    • Authors: Niravkumar D. Patel; Nandini Trivedi
      Pages: 12199 - 12203
      Abstract: The Kitaev model with an applied magnetic field in the H∥[111] direction shows two transitions: from a nonabelian gapped quantum spin liquid (QSL) to a gapless QSL at Hc1≃0.2K and a second transition at a higher field Hc2≃0.35K to a gapped partially polarized phase, where K is the strength of...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1821406116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Crossover from interaction to driven regimes in quantum vortex
           reconnections [Physics]
    • Authors: Luca Galantucci; Andrew W. Baggaley, Nick G. Parker, Carlo F. Barenghi
      Pages: 12204 - 12211
      Abstract: Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in atomic Bose–Einstein condensates (BECs) vorticity takes...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818668116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Renewable CO2 recycling and synthetic fuel production in a marine
           environment [Sustainability Science]
    • Authors: Bruce D. Patterson; Frode Mo, Andreas Borgschulte, Magne Hillestad, Fortunat Joos, Trygve Kristiansen, Svein Sunde, Jeroen A. van Bokhoven
      Pages: 12212 - 12219
      Abstract: A massive reduction in CO2 emissions from fossil fuel burning is required to limit the extent of global warming. However, carbon-based liquid fuels will in the foreseeable future continue to be important energy storage media. We propose a combination of largely existing technologies to use solar energy to recycle atmospheric...
      Keywords: Sustainability Science
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902335116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Reconstructing sexual divisions of labor from fingerprints on Ancestral
           Puebloan pottery [Anthropology]
    • Authors: John Kantner; David McKinney, Michele Pierson, Shaza Wester
      Pages: 12220 - 12225
      Abstract: An understanding of the division of labor in different societies, and especially how it evolved in the human species, is fundamental to most analyses of social, political, and economic systems. The ability to reconstruct how labor was organized, however, especially in ancient societies that left behind few material remains, is...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901367116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Temple occupation and the tempo of collapse at Angkor Wat, Cambodia
           [Anthropology]
    • Authors: Alison K. Carter; Miriam T. Stark, Seth Quintus, Yijie Zhuang, Hong Wang, Piphal Heng, Rachna Chhay
      Pages: 12226 - 12231
      Abstract: The 9th–15th century Angkorian state was Southeast Asia’s greatest premodern empire and Angkor Wat in the World Heritage site of Angkor is one of its largest religious monuments. Here we use excavation and chronometric data from three field seasons at Angkor Wat to understand the decline and reorganization of the...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1821879116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Mangroves shelter coastal economic activity from cyclones [Economic
           Sciences]
    • Authors: Jacob P. Hochard; Stuart Hamilton, Edward B. Barbier
      Pages: 12232 - 12237
      Abstract: Mangroves shelter coastlines during hazardous storm events with coastal communities experiencing mangrove deforestation are increasingly vulnerable to economic damages resulting from cyclones. To date, the benefits of mangroves in terms of protecting coastal areas have been estimated only through individual case studies of specific regions or countries. Using spatially referenced...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820067116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Evolution of global marine fishing fleets and the response of fished
           resources [Sustainability Science]
    • Authors: Yannick Rousseau; Reg A. Watson, Julia L. Blanchard, Elizabeth A. Fulton
      Pages: 12238 - 12243
      Abstract: Previous reconstructions of marine fishing fleets have aggregated data without regard to the artisanal and industrial sectors. Engine power has often been estimated from subsets of the developed world, leading to inflated results. We disaggregated data into three sectors, artisanal (unpowered/powered) and industrial, and reconstructed the evolution of the fleet...
      Keywords: Sustainability Science
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820344116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Humans adapt to social diversity over time [Social Sciences]
    • Authors: Miguel R. Ramos; Matthew R. Bennett, Douglas S. Massey, Miles Hewstone
      Pages: 12244 - 12249
      Abstract: Humans have evolved cognitive processes favoring homogeneity, stability, and structure. These processes are, however, incompatible with a socially diverse world, raising wide academic and political concern about the future of modern societies. With data comprising 22 y of religious diversity worldwide, we show across multiple surveys that humans are inclined...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818884116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Segregation through the multiscalar lens [Social Sciences]
    • Authors: Madalina Olteanu; Julien Randon-Furling, William A. V. Clark
      Pages: 12250 - 12254
      Abstract: We introduce a mathematical framework that allows one to carry out multiscalar and multigroup spatial exploratory analysis across urban regions. By producing coefficients that integrate information across all scales and that are normalized with respect to theoretical maximally segregated configurations, this framework provides a practical and powerful tool for the...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900192116
      Issue No: Vol. 116, No. 25 (2019)
       
  • The promise and peril of sexual harassment programs [Social Sciences]
    • Authors: Frank Dobbin; Alexandra Kalev
      Pages: 12255 - 12260
      Abstract: Two decades ago, the Supreme Court vetted the workplace harassment programs popular at the time: sexual harassment grievance procedures and training. However, harassment at work remains common. Do these programs reduce harassment' Program effects have been difficult to measure, but, because women frequently quit their jobs after being harassed, programs...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818477116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Economics of the disintegration of the Greenland ice sheet [Sustainability
           Science]
    • Authors: William Nordhaus
      Pages: 12261 - 12269
      Abstract: Concerns about the impact on large-scale earth systems have taken center stage in the scientific and economic analysis of climate change. The present study analyzes the economic impact of a potential disintegration of the Greenland ice sheet (GIS). The study introduces an approach that combines long-run economic growth models, climate...
      Keywords: Sustainability Science
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1814990116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Fast-moving bat ears create informative Doppler shifts [Applied Biological
           Sciences]
    • Authors: Xiaoyan Yin; Rolf Muller
      Pages: 12270 - 12274
      Abstract: Many animals have evolved adept sensory systems that enable dexterous mobility in complex environments. Echolocating bats hunting in dense vegetation represent an extreme case of this, where all necessary information about the environment must pass through a parsimonious channel of pulsed, 1D echo signals. We have investigated whether certain bats...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901120116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Inward-facing conformation of a multidrug resistance MATE family
           transporter [Biochemistry]
    • Authors: Sandra Zakrzewska; Ahmad Reza Mehdipour, Viveka Nand Malviya, Tsuyoshi Nonaka, Juergen Koepke, Cornelia Muenke, Winfried Hausner, Gerhard Hummer, Schara Safarian, Hartmut Michel
      Pages: 12275 - 12284
      Abstract: Multidrug and toxic compound extrusion (MATE) transporters mediate excretion of xenobiotics and toxic metabolites, thereby conferring multidrug resistance in bacterial pathogens and cancer cells. Structural information on the alternate conformational states and knowledge of the detailed mechanism of MATE transport are of great importance for drug development. However, the structures...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904210116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Hsp90 of E. coli modulates assembly of FtsZ, the bacterial tubulin homolog
           [Biochemistry]
    • Authors: Anuradha Balasubramanian; Monica Markovski, Joel R. Hoskins, Shannon M. Doyle, Sue Wickner
      Pages: 12285 - 12294
      Abstract: Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone involved in ATP-dependent client protein remodeling and activation. It also functions as a protein holdase, binding and stabilizing clients in an ATP-independent process. Hsp90 remodels over 300 client proteins and is essential for cell survival in eukaryotes. In bacteria,...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904014116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Unique transmembrane domain interactions differentially modulate integrin
           {alpha}v{beta}3 and {alpha}IIb{beta}3 function [Biophysics and
           Computational Biology]
    • Authors: Rustem I. Litvinov; Marco Mravic, Hua Zhu, John W. Weisel, William F. DeGrado, Joel S. Bennett
      Pages: 12295 - 12300
      Abstract: Lateral transmembrane (TM) helix–helix interactions between single-span membrane proteins play an important role in the assembly and signaling of many cell-surface receptors. Often, these helices contain two highly conserved yet distinct interaction motifs, arranged such that the motifs cannot be engaged simultaneously. However, there is sparse experimental evidence that dual-engagement...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904867116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Unfolded states under folding conditions accommodate sequence-specific
           conformational preferences with random coil-like dimensions [Biophysics
           and Computational Biology]
    • Authors: Ivan Peran; Alex S. Holehouse, Isaac S. Carrico, Rohit V. Pappu, Osman Bilsel, Daniel P. Raleigh
      Pages: 12301 - 12310
      Abstract: Proteins are marginally stable molecules that fluctuate between folded and unfolded states. Here, we provide a high-resolution description of unfolded states under refolding conditions for the N-terminal domain of the L9 protein (NTL9). We use a combination of time-resolved Förster resonance energy transfer (FRET) based on multiple pairs of minimally...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818206116
      Issue No: Vol. 116, No. 25 (2019)
       
  • LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its
           demethylase activity [Cell Biology]
    • Authors: Huiyin Lan; Mingjia Tan, Qiang Zhang, Fei Yang, Siyuan Wang, Hua Li, Xiufang Xiong, Yi Sun
      Pages: 12311 - 12320
      Abstract: FBXW7 acts as a typical tumor suppressor, with loss-of-function alterations in human cancers, by promoting ubiquitylation and degradation of many oncoproteins. Lysine-specific demethylase 1 (LSD1) is a well-characterized histone demethylase. Whether LSD1 has demethylase-independent activity remains elusive. Here we report that LSD1 directly binds to FBXW7 to destabilize FBXW7 independent...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902012116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Hypoxia induces the dormant state in oocytes through expression of Foxo3
           [Developmental Biology]
    • Authors: So Shimamoto; Yohei Nishimura, Go Nagamatsu, Norio Hamada, Haruka Kita, Orie Hikabe, Nobuhiko Hamazaki, Katsuhiko Hayashi
      Pages: 12321 - 12326
      Abstract: In mammals, most immature oocytes remain dormant in the primordial follicles to ensure the longevity of female reproductive life. A precise understanding of mechanisms underlying the dormancy is important for reproductive biology and medicine. In this study, by comparing mouse oogenesis in vivo and in vitro, the latter of which...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1817223116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Regulation of Caenorhabditis elegans neuronal polarity by heterochronic
           genes [Developmental Biology]
    • Authors: Maria Armakola; Gary Ruvkun
      Pages: 12327 - 12336
      Abstract: Many neurons display characteristic patterns of synaptic connections that are under genetic control. The Caenorhabditis elegans DA cholinergic motor neurons form synaptic connections only on their dorsal axons. We explored the genetic pathways that specify this polarity by screening for gene inactivations and mutations that disrupt this normal polarity of...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820928116
      Issue No: Vol. 116, No. 25 (2019)
       
  • A global model of island species-area relationships [Ecology]
    • Authors: Thomas J. Matthews; Francois Rigal, Kostas A. Triantis, Robert J. Whittaker
      Pages: 12337 - 12342
      Abstract: The increase in species richness with island area (ISAR) is a well-established global pattern, commonly described by the power model, the parameters of which are hypothesized to vary with system isolation and to be indicative of ecological process regimes. We tested a structural equation model of ISAR parameter variation as...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818190116
      Issue No: Vol. 116, No. 25 (2019)
       
  • On the occurrence of cytochrome P450 in viruses [Evolution]
    • Authors: David C. Lamb; Alec H. Follmer, Jared V. Goldstone, David R. Nelson, Andrew G. Warrilow, Claire L. Price, Marie Y. True, Steven L. Kelly, Thomas L. Poulos, John J. Stegeman
      Pages: 12343 - 12352
      Abstract: Genes encoding cytochrome P450 (CYP; P450) enzymes occur widely in the Archaea, Bacteria, and Eukarya, where they play important roles in metabolism of endogenous regulatory molecules and exogenous chemicals. We now report that genes for multiple and unique P450s occur commonly in giant viruses in the Mimiviridae, Pandoraviridae, and other...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901080116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Possible cooption of a VEGF-driven tubulogenesis program for
           biomineralization in echinoderms [Evolution]
    • Authors: Miri Morgulis; Tsvia Gildor, Modi Roopin, Noa Sher, Assaf Malik, Maya Lalzar, Monica Dines, Shlomo Ben-Tabou de-Leon, Lama Khalaily, Smadar Ben-Tabou de-Leon
      Pages: 12353 - 12362
      Abstract: Biomineralization is the process by which living organisms use minerals to form hard structures that protect and support them. Biomineralization is believed to have evolved rapidly and independently in different phyla utilizing preexisting components. The mechanistic understanding of the regulatory networks that drive biomineralization and their evolution is far from...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902126116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Ancient Yersinia pestis genomes from across Western Europe reveal early
           diversification during the First Pandemic (541-750) [Evolution]
    • Authors: Marcel Keller; Maria A. Spyrou, Christiana L. Scheib, Gunnar U. Neumann, Andreas Kropelin, Brigitte Haas–Gebhard, Bernd Paffgen, Jochen Haberstroh, Albert Ribera i Lacomba, Claude Raynaud, Craig Cessford, Raphael Durand, Peter Stadler, Kathrin Nagele, Jessica S. Bates, Bernd Trautmann, Sarah A. Inskip, Joris Peters, John E. Robb, Toomas Kivisild, Dominique Castex, Michael McCormick, Kirsten I. Bos, Michaela Harbeck, Alexander Herbig, Johannes Krause
      Pages: 12363 - 12372
      Abstract: The first historically documented pandemic caused by Yersinia pestis began as the Justinianic Plague in 541 within the Roman Empire and continued as the so-called First Pandemic until 750. Although paleogenomic studies have previously identified the causative agent as Y. pestis, little is known about the bacterium’s spread, diversity, and...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820447116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Adult sex ratio influences mate choice in Darwin’s finches
           [Evolution]
    • Authors: Peter R. Grant; B. Rosemary Grant
      Pages: 12373 - 12382
      Abstract: The adult sex ratio (ASR) is an important property of populations. Comparative phylogenetic analyses have shown that unequal sex ratios are associated with the frequency of changing mates, extrapair mating (EPM), mating system and parental care, sex-specific survival, and population dynamics. Comparative demographic analyses are needed to validate the inferences,...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1903838116
      Issue No: Vol. 116, No. 25 (2019)
       
  • A major role for noncoding regulatory mutations in the evolution of enzyme
           activity [Evolution]
    • Authors: David W. Loehlin; Jesse R. Ames, Kathy Vaccaro, Sean B. Carroll
      Pages: 12383 - 12389
      Abstract: The quantitative evolution of protein activity is a common phenomenon, yet we know little about any general mechanistic tendencies that underlie it. For example, an increase (or decrease) in enzyme activity may evolve from changes in protein sequence that alter specific activity, or from changes in gene expression that alter...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1904071116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Preformed chromatin topology assists transcriptional robustness of Shh
           during limb development [Genetics]
    • Authors: Christina Paliou; Philine Guckelberger, Robert Schopflin, Verena Heinrich, Andrea Esposito, Andrea M. Chiariello, Simona Bianco, Carlo Annunziatella, Johannes Helmuth, Stefan Haas, Ivana Jerković, Norbert Brieske, Lars Wittler, Bernd Timmermann, Mario Nicodemi, Martin Vingron, Stefan Mundlos, Guillaume Andrey
      Pages: 12390 - 12399
      Abstract: Long-range gene regulation involves physical proximity between enhancers and promoters to generate precise patterns of gene expression in space and time. However, in some cases, proximity coincides with gene activation, whereas, in others, preformed topologies already exist before activation. In this study, we investigate the preformed configuration underlying the regulation...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900672116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Building bridges to move recombination complexes [Genetics]
    • Authors: Emeline Dubois; Arnaud De Muyt, Jessica L. Soyer, Karine Budin, Mathieu Legras, Tristan Piolot, Robert Debuchy, Nancy Kleckner, Denise Zickler, Eric Espagne
      Pages: 12400 - 12409
      Abstract: A central feature of meiosis is pairing of homologous chromosomes, which occurs in two stages: coalignment of axes followed by installation of the synaptonemal complex (SC). Concomitantly, recombination complexes reposition from on-axis association to the SC central region. We show here that, in the fungus Sordaria macrospora, this critical transition...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901237116
      Issue No: Vol. 116, No. 25 (2019)
       
  • TOX and TOX2 transcription factors cooperate with NR4A transcription
           factors to impose CD8+ T cell exhaustion [Immunology and Inflammation]
    • Authors: Hyungseok Seo; Joyce Chen, Edahi Gonzalez–Avalos, Daniela Samaniego–Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. Lopez–Moyado, Romain O. Georges, Wade Zhang, Atsushi Onodera, Cheng–Jang Wu, Li–Fan Lu, Patrick G. Hogan, Avinash Bhandoola, Anȷana Rao
      Pages: 12410 - 12415
      Abstract: T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive (“exhausted” or “dysfunctional”) within the tumor microenvironment, with decreased cytokine production and increased expression of several inhibitory surface...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1905675116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7
           microRNA in macrophages [Immunology and Inflammation]
    • Authors: Shuai Jiang; Wei Yan, Shizhen Emily Wang, David Baltimore
      Pages: 12416 - 12421
      Abstract: Tet methylcytosine dioxygenase 2 (Tet2) is an epigenetic regulator that removes methyl groups from deoxycytosine residues in DNA. Tet2-deficient murine macrophages show increased lipopolysaccharide (LPS)-induced and spontaneous inflammation at least partially because Tet2 acts to restrain interleukin (IL)-1β and IL-6 expression in induced cells. MicroRNAs have emerged as critical regulatory...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1811040116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Protein phosphatase 2A has an essential role in promoting thymocyte
           survival during selection [Immunology and Inflammation]
    • Authors: Mingzhu Zheng; Dan Li, Zhishan Zhao, Dmytro Shytikov, Qin Xu, Xuexiao Jin, Jingjing Liang, Jun Lou, Songquan Wu, Lie Wang, Hu Hu, Yiting Zhou, Xiang Gao, Linrong Lu
      Pages: 12422 - 12427
      Abstract: The development of thymocytes to mature T cells in the thymus is tightly controlled by cellular selection, in which only a small fraction of thymocytes equipped with proper quality of TCRs progress to maturation. It is pivotal to protect the survival of the few T cells, which pass the selection....
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1821116116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Olfactory sensory neurons mediate ultrarapid antiviral immune responses in
           a TrkA-dependent manner [Immunology and Inflammation]
    • Authors: Ali Sepahi; Aurora Kraus, Elisa Casadei, Christopher A. Johnston, Jorge Galindo–Villegas, Cecelia Kelly, Diana Garcia–Moreno, Pilar Munoz, Victoriano Mulero, Mar Huertas, Irene Salinas
      Pages: 12428 - 12436
      Abstract: The nervous system regulates host immunity in complex ways. Vertebrate olfactory sensory neurons (OSNs) are located in direct contact with pathogens; however, OSNs’ ability to detect danger and initiate immune responses is unclear. We report that nasal delivery of rhabdoviruses induces apoptosis in crypt OSNs via the interaction of the...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900083116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Boundary mode lubrication of articular cartilage with a biomimetic diblock
           copolymer [Medical Sciences]
    • Authors: Zhexun Sun; Elizabeth Feeney, Ya Guan, Sierra G. Cook, Delphine Gourdon, Lawrence J. Bonassar, David Putnam
      Pages: 12437 - 12441
      Abstract: We report the design of a diblock copolymer with architecture and function inspired by the lubricating glycoprotein lubricin. This diblock copolymer, synthesized by sequential reversible addition–fragmentation chain-transfer polymerization, consists of a cationic cartilage-binding domain and a brush-lubricating domain. It reduces the coefficient of friction of articular cartilage under boundary mode...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1900716116
      Issue No: Vol. 116, No. 25 (2019)
       
  • JAK/STAT inhibition in macrophages promotes therapeutic resistance by
           inducing expression of protumorigenic factors [Medical Sciences]
    • Authors: Emily A. Irey; Chelsea M. Lassiter, Nicholas J. Brady, Pavlina Chuntova, Ying Wang, Todd P. Knutson, Christine Henzler, Thomas S. Chaffee, Rachel I. Vogel, Andrew C. Nelson, Michael A. Farrar, Kathryn L. Schwertfeger
      Pages: 12442 - 12451
      Abstract: Tumor-associated macrophages contribute to tumor progression and therapeutic resistance in breast cancer. Within the tumor microenvironment, tumor-derived factors activate pathways that modulate macrophage function. Using in vitro and in vivo models, we find that tumor-derived factors induce activation of the Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3)...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1816410116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine
           resistance in breast cancer [Medical Sciences]
    • Authors: Matteo Morotti; Esther Bridges, Alessandro Valli, Hani Choudhry, Helen Sheldon, Simon Wigfield, Nicki Gray, Christos E. Zois, Fiona Grimm, Dylan Jones, Eugene J. Teoh, Wei-Chen Cheng, Simon Lord, Dimitrios Anastasiou, Syed Haider, Alan McIntyre, Deborah C. I. Goberdhan, Francesca Buffa, Adrian L. Harris
      Pages: 12452 - 12461
      Abstract: Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα+) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine transporter, SNAT2, is the AA transporter most frequently induced by hypoxia in breast cancer,...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818521116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Salmonella biofilms program innate immunity for persistence in
           Caenorhabditis elegans [Microbiology]
    • Authors: Stuti K. Desai; Anup Padmanabhan, Sharvari Harshe, Ronen Zaidel-Bar, Linda J. Kenney
      Pages: 12462 - 12467
      Abstract: The adaptive in vivo mechanisms underlying the switch in Salmonella enterica lifestyles from the infectious form to a dormant form remain unknown. We employed Caenorhabditis elegans as a heterologous host to understand the temporal dynamics of Salmonella pathogenesis and to identify its lifestyle form in vivo. We discovered that Salmonella...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1822018116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Ammonia generation by tryptophan synthase drives a key genetic difference
           between genital and ocular Chlamydia trachomatis isolates [Microbiology]
    • Authors: Shardulendra P. Sherchand; Ashok Aiyar
      Pages: 12468 - 12477
      Abstract: A striking difference between genital and ocular clinical isolates of Chlamydia trachomatis is that only the former express a functional tryptophan synthase and therefore can synthesize tryptophan by indole salvage. Ocular isolates uniformly cannot use indole due to inactivating mutations within tryptophan synthase, indicating a selection against maintaining this enzyme...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1821652116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Primary structural differences at residue 226 of deer and elk PrP dictate
           selection of distinct CWD prion strains in gene-targeted mice
           [Microbiology]
    • Authors: Jifeng Bian; Jeffrey R. Christiansen, Julie A. Moreno, Sarah J. Kane, Vadim Khaychuk, Joseph Gallegos, Sehun Kim, Glenn C. Telling
      Pages: 12478 - 12487
      Abstract: Although the unifying hallmark of prion diseases is CNS neurodegeneration caused by conformational corruption of host prion protein (PrP) to its infective counterpart, contagious transmission of chronic wasting disease (CWD) results from shedding of prions produced at high titers in the periphery of diseased cervids. While deer and elk PrP...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1903947116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Stress transforms lateral habenula reward responses into punishment
           signals [Neuroscience]
    • Authors: Steven J. Shabel; Chenyu Wang, Bradley Monk, Sage Aronson, Roberto Malinow
      Pages: 12488 - 12493
      Abstract: Neuronal activity in the lateral habenula (LHb), a brain region implicated in depression [C. D. Proulx, O. Hikosaka, R. Malinow, Nat. Neurosci. 17, 1146–1152 (2014)], decreases during reward and increases during punishment or reward omission [M. Matsumoto, O. Hikosaka, Nature 447, 1111–1115 (2007)]. While stress is a major risk factor...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1903334116
      Issue No: Vol. 116, No. 25 (2019)
       
  • ANO1/TMEM16A regulates process maturation in radial glial cells in the
           developing brain [Neuroscience]
    • Authors: Gyu-Sang Hong; Sung Hoon Lee, Byeongjun Lee, Jae Hyouk Choi, Soo-Jin Oh, Yongwoo Jang, Eun Mi Hwang, Hyungsup Kim, Jooyoung Jung, In-Beom Kim, Uhtaek Oh
      Pages: 12494 - 12499
      Abstract: Neural stem cells (NSCs) are primary progenitor cells in the early developmental stage in the brain that initiate a diverse lineage of differentiated neurons and glia. Radial glial cells (RGCs), a type of neural stem cell in the ventricular zone, are essential for nurturing and delivering new immature neurons to...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1901067116
      Issue No: Vol. 116, No. 25 (2019)
       
  • UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity
           and dendritic spine morphology [Neuroscience]
    • Authors: Jie Wang; Sen-Sen Lou, Tingting Wang, Rong-Jie Wu, Guangying Li, Miao Zhao, Bin Lu, Yi-Yan Li, Jing Zhang, Xuewen Cheng, Ya Shen, Xing Wang, Zhi-Chuan Zhu, Ming-Jie Li, Toru Takumi, Hui Yang, Xiang Yu, Lujian Liao, Zhi-Qi Xiong
      Pages: 12500 - 12505
      Abstract: Deficiency in the E3 ubiquitin ligase UBE3A leads to the neurodevelopmental disorder Angelman syndrome (AS), while additional dosage of UBE3A is linked to autism spectrum disorder. The mechanisms underlying the downstream effects of UBE3A gain or loss of function in these neurodevelopmental disorders are still not well understood, and effective...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820131116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Routing information flow by separate neural synchrony frequencies allows
           for “functionally labeled lines” in higher primate cortex
           [Neuroscience]
    • Authors: Mohammad Bagher Khamechian; Vladislav Kozyrev, Stefan Treue, Moein Esghaei, Mohammad Reza Daliri
      Pages: 12506 - 12515
      Abstract: Efficient transfer of sensory information to higher (motor or associative) areas in primate visual cortical areas is crucial for transforming sensory input into behavioral actions. Dynamically increasing the level of coordination between single neurons has been suggested as an important contributor to this efficiency. We propose that differences between the...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1819827116
      Issue No: Vol. 116, No. 25 (2019)
       
  • NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates
           cognitive deficits in mouse Alzheimer’s models [Neuroscience]
    • Authors: Gahee Bahn; Jong-Sung Park, Ui Jeong Yun, Yoon Jee Lee, Yuri Choi, Jin Su Park, Seung Hyun Baek, Bo Youn Choi, Yoon Suk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Jinhwan Lim, Nobunao Wakabayashi, Soo Han Bae, Jeung-Whan Han, Thiruma V. Arumugam, Mark P. Mattson, Dong-Gyu Jo
      Pages: 12516 - 12523
      Abstract: BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer’s disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expression plays an...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1819541116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Specific factors in blood from young but not old mice directly promote
           synapse formation and NMDA-receptor recruitment [Neuroscience]
    • Authors: Kathlyn J. Gan; Thomas C. Sudhof
      Pages: 12524 - 12533
      Abstract: Aging drives a progressive decline in cognition and decreases synapse numbers and synaptic function in the brain, thereby increasing the risk for neurodegenerative disease. Pioneering studies showed that introduction of blood from young mice into aged mice reversed age-associated cognitive impairments and increased synaptic connectivity in brain, suggesting that young...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902672116
      Issue No: Vol. 116, No. 25 (2019)
       
  • The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in
           Arabidopsis [Plant Biology]
    • Authors: Erik Wiȷnker; Hirofumi Harashima, Katȷa Muller, Pablo Parra–Nunez, C. Bastiaan de Snoo, Jose van de Belt, Nico Dissmeyer, Martin Bayer, Monica Pradillo, Arp Schnittger
      Pages: 12534 - 12539
      Abstract: Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis. Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820753116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Arabidopsis ABCG28 is required for the apical accumulation of reactive
           oxygen species in growing pollen tubes [Plant Biology]
    • Authors: Thanh Ha Thi Do; Hyunju Choi, Michael Palmgren, Enrico Martinoia, Jae-Ung Hwang, Youngsook Lee
      Pages: 12540 - 12549
      Abstract: Tip-focused accumulation of reactive oxygen species (ROS) is tightly associated with pollen tube growth and is thus critical for fertilization. However, it is unclear how tip-growing cells establish such specific ROS localization. Polyamines have been proposed to function in tip growth as precursors of the ROS, hydrogen peroxide. The ABC...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902010116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Engineering the phototropin photocycle improves photoreceptor performance
           and plant biomass production [Plant Biology]
    • Authors: Jaynee E. Hart; Stuart Sullivan, Paweł Hermanowicz, Jan Petersen, L. Aranzazu Diaz–Ramos, David J. Hoey, Justyna Łabuz, John M. Christie
      Pages: 12550 - 12557
      Abstract: The ability to enhance photosynthetic capacity remains a recognized bottleneck to improving plant productivity. Phototropin blue light receptors (phot1 and phot2) optimize photosynthetic efficiency in Arabidopsis thaliana by coordinating multiple light-capturing processes. In this study, we explore the potential of using protein engineering to improve photoreceptor performance and thereby plant...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1902915116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Plant-derived coumarins shape the composition of an Arabidopsis synthetic
           root microbiome [Plant Biology]
    • Authors: Mathias J. E. E. E. Voges; Yang Bai, Paul Schulze-Lefert, Elizabeth S. Sattely
      Pages: 12558 - 12565
      Abstract: The factors that contribute to the composition of the root microbiome and, in turn, affect plant fitness are not well understood. Recent work has highlighted a major contribution of the soil inoculum in determining the composition of the root microbiome. However, plants are known to conditionally exude a diverse array...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1820691116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Elephants have a nose for quantity [Psychological and Cognitive Sciences]
    • Authors: Joshua M. Plotnik; Daniel L. Brubaker, Rachel Dale, Lydia N. Tiller, Hannah S. Mumby, Nicola S. Clayton
      Pages: 12566 - 12571
      Abstract: Animals often face situations that require making decisions based on quantity. Many species, including humans, rely on an ability to differentiate between more and less to make judgments about social relationships, territories, and food. Habitat-related choices require animals to decide between areas with greater and lesser quantities of food while...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1818284116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Correction for Lorenzo et al., Computer simulations suggest that prostate
           enlargement due to benign prostatic hyperplasia mechanically impedes
           prostate cancer growth [Correction]
    • Pages: 12572 - 12572
      Abstract: ENGINEERING Correction for “Computer simulations suggest that prostate enlargement due to benign prostatic hyperplasia mechanically impedes prostate cancer growth,” by Guillermo Lorenzo, Thomas J. R. Hughes, Pablo Dominguez-Frojan, Alessandro Reali, and Hector Gomez, which was first published January 7, 2019; 10.1073/pnas.1815735116 (Proc. Natl. Acad. Sci. U.S.A. 116, 1152–1161). The authors...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908514116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Correction for Li et al., Activation of RNase L is dependent on OAS3
           expression during infection with diverse human viruses [Correction]
    • Pages: 12573 - 12573
      Abstract: MICROBIOLOGY Correction for “Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses,” by Yize Li, Shuvojit Banerjee, Yuyan Wang, Stephen A. Goldstein, Beihua Dong, Christina Gaughan, Robert H. Silverman, and Susan R. Weiss, which was first published February 8, 2016; 10.1073/pnas.1519657113 (Proc. Natl. Acad....
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908765116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Correction for Dutta et al., Regulation of myelin structure and conduction
           velocity by perinodal astrocytes [Correction]
    • Pages: 12574 - 12574
      Abstract: NEUROSCIENCE Correction for “Regulation of myelin structure and conduction velocity by perinodal astrocytes,” by Dipankar J. Dutta, Dong Ho Woo, Philip R. Lee, Sinisa Pajevic, Olena Bukalo, William C. Huffman, Hiroaki Wake, Peter J. Basser, Shahriar SheikhBahaei, Vanja Lazarevic, Jeffrey C. Smith, and R. Douglas Fields, which was first published...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908361116
      Issue No: Vol. 116, No. 25 (2019)
       
  • Correction for Jang et al., Processing bodies control the selective
           translation for optimal development of Arabidopsis young seedlings
           [Correction]
    • Pages: 12575 - 12575
      Abstract: PLANT BIOLOGY Correction for “Processing bodies control the selective translation for optimal development of Arabidopsis young seedlings,” by Geng-Jen Jang, Jun-Yi Yang, Hsu-Liang Hsieh, and Shu-Hsing Wu, which was first published March 8, 2019; 10.1073/pnas.1900084116 (Proc. Natl. Acad. Sci. U.S.A. 116, 6451–6456). The authors note that the grant numbers for...
      PubDate: 2019-06-18T09:48:31-07:00
      DOI: 10.1073/pnas.1908132116
      Issue No: Vol. 116, No. 25 (2019)
       
 
 
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