Journal Cover
Nature Structural & Molecular Biology
Journal Prestige (SJR): 10.873
Citation Impact (citeScore): 10
Number of Followers: 228  
 
  Full-text available via subscription Subscription journal
ISSN (Print) 1545-9993 - ISSN (Online) 1545-9985
Published by NPG Homepage  [138 journals]
  • FACT mediates cohesin function on chromatin
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0307-x

      The histone chaperone FACT interacts directly with cohesin and contributes to the functions of cohesin in nuclear organization during interphase and during mitotic chromosome folding in S. cerevisiae.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0307-x2019-10-03
      DOI: 10.1038/s41594-019-0307-x
       
  • Rapid transcriptional bursts upregulate the X chromosome
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0314-y

      Upregulation of the X chromosome compensates for the presence of a single active X chromosome in mammals, but this has been difficult to measure and to understand mechanistically. A study now demonstrates that increased burst frequency boosts the transcriptional output of X-linked genes in male and female cells with a single active X chromosome. Interestingly, female embryonic stem cells lack increased burst frequency, which is established only after inactivation of the X chromosome takes place; this finding reveals a switch that can modulate transcriptional bursting.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0314-y2019-10-03
      DOI: 10.1038/s41594-019-0314-y
       
  • Cryo-EM of multiple cage architectures reveals a universal mode of
           clathrin self-assembly
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0292-0

      Cryo-EM maps of different clathrin cage architectures and accompanying analyses lead to a consensus model of the clathrin triskelion hub, suggesting a universal assembly mode that still allows adaptation to various vesicle sizes and shapes.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0292-02019-10-03
      DOI: 10.1038/s41594-019-0292-0
       
  • RNA-modifying enzymes and their function in a chromatin context
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0312-0

      Tzelepis, Rausch and Kouzarides review the action of RNA modifications in the context of chromatin and discuss the emerging potential of RNA-modifying enzymes as new drug targets.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0312-02019-10-03
      DOI: 10.1038/s41594-019-0312-0
       
  • Histone lysine methyltransferases in biology and disease
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0298-7

      Husmann and Gozani review the biochemical and biological activities of histone lysine methyltransferases and their connections to human diseases, focusing on cancer.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0298-72019-10-03
      DOI: 10.1038/s41594-019-0298-7
       
  • Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ
           holoenzyme
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0305-z

      A unique arrangement of catalytic and regulatory subunits revealed by cryo-EM analysis of DNA polymerase δ holoenzyme in a template–primer complex suggests how interactions between the functional modules promote DNA synthesis and proofreading activities.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0305-z2019-10-03
      DOI: 10.1038/s41594-019-0305-z
       
  • Bromodomain biology and drug discovery
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0309-8

      Zaware and Zhou review the current understanding of bromodomain biology and discuss the latest development of small-molecule inhibitors that target these protein domains as emerging therapies for cancer and inflammatory disorders.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0309-82019-10-03
      DOI: 10.1038/s41594-019-0309-8
       
  • Targeting non-bromodomain chromatin readers
    • Nature Structural & Molecular Biology, Published online: 03 October 2019; doi:10.1038/s41594-019-0290-2

      Arrowsmith and Schapira review recent progress in the discovery of drug-like small molecules that antagonize the function of non-bromodomain chromatin readers.Nature Structural & Molecular Biology, Published online: 2019-10-03; doi:10.1038/s41594-019-0290-22019-10-03
      DOI: 10.1038/s41594-019-0290-2
       
 
 
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