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Journal Cover Nature Reviews Neuroscience
  [SJR: 21.499]   [H-I: 309]   [310 followers]  Follow
    
   Full-text available via subscription Subscription journal  (Not entitled to full-text)
   ISSN (Print) 1471-003X - ISSN (Online) 1471-0048
   Published by NPG Homepage  [124 journals]
  • Neurodegenerative disease: A chimeric approach
    • Authors: Darran Yates
      Pages: 193 - 193
      Abstract: In a new, chimeric model of Alzheimer disease (AD), in which human neurons were transplanted into an AD mouse model, amyloid-β-related pathology was associated with robust degeneration of the human neurons but no neurofibrillary tangle formation.
      Citation: Nature Reviews Neuroscience 18, 193 (2017)
      PubDate: 2017-03-17
      DOI: 10.1038/nrn.2017.38
      Issue No: Vol. 18, No. 4 (2017)
       
  • Sensory processing: The eyes have it
    • Authors: Sian Lewis
      Pages: 194 - 194
      Abstract: Direction selectivity is an important part of motion detection. Direction-selective cells have been found both in the retina and in their projection target, the superior colliculus (SC), but precisely where and how direction selectivity arises is not well understood. By optogenetically manipulating specific direction-selective retinal
      Citation: Nature Reviews Neuroscience 18, 194 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.31
      Issue No: Vol. 18, No. 4 (2017)
       
  • Neural development: Digit development
    • Authors: Sian Lewis
      Pages: 194 - 194
      Abstract: The specification of the motor neuron subtypes that innervate digits is not well understood. Limb-innervating motor neuron specification is influenced by retinoic acid, the synthesis of which is regulated by specific expression patterns of homeobox (HOX) transcription factors and their cofactor FOXP1 (forkhead box protein
      Citation: Nature Reviews Neuroscience 18, 194 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.32
      Issue No: Vol. 18, No. 4 (2017)
       
  • Sleep: Gaining sleep while losing synapses
    • Authors: Sian Lewis
      Pages: 194 - 194
      Abstract: It has been suggested that synaptic weakening occurs during sleep to counterbalance daytime synaptic strengthening. The authors found that sleep was associated with a reduction in the level of postsynaptic AMPA receptors compared with awake periods, indicating homeostatic scaling down. The mechanism involves expression of
      Citation: Nature Reviews Neuroscience 18, 194 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.33
      Issue No: Vol. 18, No. 4 (2017)
       
  • Synaptic plasticity: Kainate receptors can LTP
    • Authors: Sian Lewis
      Pages: 194 - 194
      Abstract: Classical synaptic long-term potentiation (LTP) requires NMDA receptor (NMDAR) activation, which drives AMPA receptor (AMPAR) insertion into the postsynaptic membrane. Here, activation of kainate receptors (KARs) in rat CA1 neurons triggered an increase in postsynaptic AMPAR surface expression and potentiated AMPAR-mediated CA1 excitatory postsynaptic responses.
      Citation: Nature Reviews Neuroscience 18, 194 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.34
      Issue No: Vol. 18, No. 4 (2017)
       
  • Learning and memory: Remembering where not to go
    • Authors: Natasha Bray
      Pages: 195 - 195
      Abstract: In rats, CA1 place cells that encode the location of an aversive experience are reactivated during retrieval of the memory of that event.
      Citation: Nature Reviews Neuroscience 18, 195 (2017)
      PubDate: 2017-03-09
      DOI: 10.1038/nrn.2017.37
      Issue No: Vol. 18, No. 4 (2017)
       
  • Cell biology of the neuron: Lightening the load
    • Authors: Natasha Bray
      Pages: 195 - 195
      Abstract: Touch neurons in Caenorhabditis elegans eliminate aggregated or neurotoxic proteins and dysfunctional mitochondria by exporting them in large vesicles called exophers.
      Citation: Nature Reviews Neuroscience 18, 195 (2017)
      PubDate: 2017-02-23
      DOI: 10.1038/nrn.2017.27
      Issue No: Vol. 18, No. 4 (2017)
       
  • Pain: A gatekeeper circuit
    • Authors: Katherine Whalley
      Pages: 195 - 195
      Abstract: The dissection of a circuit for the descending modulation of pain processing in the spinal cord that is recruited by stress.
      Citation: Nature Reviews Neuroscience 18, 195 (2017)
      PubDate: 2017-02-23
      DOI: 10.1038/nrn.2017.28
      Issue No: Vol. 18, No. 4 (2017)
       
  • Sense of agency in the human brain
    • Authors: Patrick Haggard
      Pages: 196 - 207
      Abstract: In adult life, people normally know what they are doing. This experience of controlling one's own actions and, through them, the course of events in the outside world is called 'sense of agency'. It forms a central feature of human experience; however, the brain mechanisms
      Citation: Nature Reviews Neuroscience 18, 196 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.14
      Issue No: Vol. 18, No. 4 (2017)
       
  • Operation and plasticity of hippocampal CA3 circuits: implications for
           memory encoding
    • Authors: Nelson Rebola, Mario Carta, Christophe Mulle
      Pages: 208 - 220
      Abstract: The CA3 region of the hippocampus is important for rapid encoding of memory. Computational theories have proposed specific roles in hippocampal function and memory for the sparse inputs from the dentate gyrus to CA3 and for the extended local recurrent connectivity that gives rise to
      Citation: Nature Reviews Neuroscience 18, 208 (2017)
      PubDate: 2017-03-02
      DOI: 10.1038/nrn.2017.10
      Issue No: Vol. 18, No. 4 (2017)
       
  • Integration of optogenetics with complementary methodologies in systems
           neuroscience
    • Authors: Christina K. Kim, Avishek Adhikari, Karl Deisseroth
      Pages: 222 - 235
      Abstract: Modern optogenetics can be tuned to evoke activity that corresponds to naturally occurring local or global activity in timing, magnitude or individual-cell patterning. This outcome has been facilitated not only by the development of core features of optogenetics over the past 10 years (microbial-opsin variants,
      Citation: Nature Reviews Neuroscience 18, 222 (2017)
      PubDate: 2017-03-17
      DOI: 10.1038/nrn.2017.15
      Issue No: Vol. 18, No. 4 (2017)
       
  • NMDA receptors: linking physiological output to biophysical operation
    • Authors: Gary J. Iacobucci, Gabriela K. Popescu
      Pages: 236 - 249
      Abstract: NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which respond to glutamate in a manner that integrates multiple external and internal cues. They belong to the ionotropic glutamate receptor family and fulfil unique and crucial roles in neuronal development and function. These roles depend
      Citation: Nature Reviews Neuroscience 18, 236 (2017)
      PubDate: 2017-03-17
      DOI: 10.1038/nrn.2017.24
      Issue No: Vol. 18, No. 4 (2017)
       
  • The two-century journey of Parkinson disease research
    • Authors: Serge Przedborski
      Pages: 251 - 259
      Abstract: Since the first formal description of Parkinson disease (PD) two centuries ago, our understanding of this common neurodegenerative disorder has expanded at all levels of description, from the delineation of its clinical phenotype to the identification of its neuropathological features, neurochemical processes and genetic factors.
      Citation: Nature Reviews Neuroscience 18, 251 (2017)
      PubDate: 2017-03-17
      DOI: 10.1038/nrn.2017.25
      Issue No: Vol. 18, No. 4 (2017)
       
 
 
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