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Journal Cover Nature Reviews Neuroscience
  [SJR: 14.685]   [H-I: 259]   [241 followers]  Follow
    
   Full-text available via subscription Subscription journal
   ISSN (Print) 1471-003X - ISSN (Online) 1471-0048
   Published by NPG Homepage  [123 journals]
  • Learning and memory: Once upon a recent time
    • Authors: Natasha Bray
      Pages: 397 - 397
      Abstract: There is greater 'overlap' between the sets of CA1 neurons encoding temporally close memories than of neurons encoding memories temporally spaced apart; such overlap may enable linking of temporally close memories.
      Citation: Nature Reviews Neuroscience 17, 397 (2016)
      PubDate: 2016-06-09
      DOI: 10.1038/nrn.2016.84
      Issue No: Vol. 17, No. 7 (2016)
       
  • Glia: An astrocytic axis
    • Authors: Natasha Bray
      Pages: 398 - 399
      Abstract: In experimental autoimmune encephalitis (a mouse model of multiple sclerosis), type I interferons stimulate the production of aryl hydrocarbon receptor, which is activated by diet- and microbe-derived molecules and limits CNS inflammation.
      Citation: Nature Reviews Neuroscience 17, 398 (2016)
      PubDate: 2016-06-03
      DOI: 10.1038/nrn.2016.77
      Issue No: Vol. 17, No. 7 (2016)
       
  • Neurodegenerative disease: Ever decreasing ripples
    • Authors: Sian Lewis
      Pages: 398 - 399
      Abstract: Slow gamma oscillations during sharp-wave ripples in hippocampus are reduced in mice expressing human APOE4 and this is associated with age-related deficits in learning and memory.
      Citation: Nature Reviews Neuroscience 17, 398 (2016)
      PubDate: 2016-05-26
      DOI: 10.1038/nrn.2016.71
      Issue No: Vol. 17, No. 7 (2016)
       
  • Neuroendocrinology: Switching on puberty
    • Authors: Katherine Whalley
      Pages: 399 - 399
      Abstract: Puberty onset is coordinated by gonadotropin-releasing hormone (GnRH)-secreting hypothalamic neurons. Here, the authors show that impairing microRNA (miRNA) synthesis causes hypergonadism and sterility in mice. They find that two key miRNAs — miR-200 and miR-155 — target genes that control the activity of the Gnrh
      Citation: Nature Reviews Neuroscience 17, 399 (2016)
      PubDate: 2016-06-03
      DOI: 10.1038/nrn.2016.76
      Issue No: Vol. 17, No. 7 (2016)
       
  • Techniques: A CRISPR method of localization
    • Authors: Katherine Whalley
      Pages: 399 - 399
      Abstract: Genome editing using the CRISPR–Cas9 system allows the manipulation of specific genes. Mikuni et al. use this approach to insert sequences encoding protein tags into genes of interest in neural progenitors in the embryonic mouse brain, enabling them to map endogenous protein localization in
      Citation: Nature Reviews Neuroscience 17, 399 (2016)
      PubDate: 2016-06-03
      DOI: 10.1038/nrn.2016.75
      Issue No: Vol. 17, No. 7 (2016)
       
  • Neurodevelopmental disorders: Zika virus causes brain defects in mice
    • Authors: Katherine Whalley
      Pages: 399 - 399
      Abstract: The Brazilian Zika virus (ZIKVBR) outbreak has been linked to increased incidence of microcephaly; however, in vivo evidence for the effects of ZIKVBR on brain development is lacking. The authors show that pups born to SJL mice infected with ZIKV
      Citation: Nature Reviews Neuroscience 17, 399 (2016)
      PubDate: 2016-06-03
      DOI: 10.1038/nrn.2016.74
      Issue No: Vol. 17, No. 7 (2016)
       
  • Depression: Breaking down ketamine's actions
    • Authors: Katherine Whalley
      Pages: 399 - 399
      Abstract: Ketamine's usefulness as an antidepressant is limited by side effects, including abuse potential and sensory dissociation, and its mechanism of action remains unclear. Here, the authors show that ketamine mediates its antidepressant activity not through NMDA receptor inhibition, as previously assumed, but by boosting AMPA
      Citation: Nature Reviews Neuroscience 17, 399 (2016)
      PubDate: 2016-06-03
      DOI: 10.1038/nrn.2016.73
      Issue No: Vol. 17, No. 7 (2016)
       
  • Neurophysiology: Going with the flow
    • Authors: Sian Lewis
      Pages: 400 - 400
      Abstract: The spatial scale over which changes in neural activity influence local blood flow remains under debate. Here, blood vessel diameter and adjacent neuronal spiking activity in the cat visual cortex were monitored simultaneously during exposure of the animal to a range of stimulus orientations. Parenchymal
      Citation: Nature Reviews Neuroscience 17, 400 (2016)
      PubDate: 2016-06-20
      DOI: 10.1038/nrn.2016.83
      Issue No: Vol. 17, No. 7 (2016)
       
  • Sleep and memory: Sleeping through the performance
    • Authors: Sian Lewis
      Pages: 400 - 400
      Abstract: The consolidation of memory traces during sleep for their long-term storage in the cortex has not been demonstrated directly. Maingret et al. trained rats either in a spatial memory task that required consolidation or a task that did not. They found that hippocampo-cortical oscillatory
      Citation: Nature Reviews Neuroscience 17, 400 (2016)
      PubDate: 2016-06-20
      DOI: 10.1038/nrn.2016.82
      Issue No: Vol. 17, No. 7 (2016)
       
  • Cell biology of the neuron: Life in the slow lane
    • Authors: Sian Lewis
      Pages: 400 - 400
      Abstract: Dynein is a molecular motor that is involved in retrograde axonal transport, but the mechanism by which it reaches distal axonal locations is incompletely understood. Here, the authors used live cell imaging techniques in the mouse brain and found that dynein undergoes anterograde transport as
      Citation: Nature Reviews Neuroscience 17, 400 (2016)
      PubDate: 2016-06-20
      DOI: 10.1038/nrn.2016.81
      Issue No: Vol. 17, No. 7 (2016)
       
  • Neurodegenerative disease: Restoring balance
    • Authors: Sian Lewis
      Pages: 400 - 400
      Abstract: Intracellular accumulation of the microtubule-associated protein tau is a hallmark of Alzheimer disease. Alternative splicing of the gene encoding tau can generate tau isoforms with three repeat domains (3R) or four repeat domains (4R), and it has been hypothesized that an excess of 4R tau
      Citation: Nature Reviews Neuroscience 17, 400 (2016)
      PubDate: 2016-06-20
      DOI: 10.1038/nrn.2016.80
      Issue No: Vol. 17, No. 7 (2016)
       
  • Glia: Astrocytic go-betweens
    • Authors: Darran Yates
      Pages: 400 - 400
      Abstract: Septal cholinergic neurons inhibit hippocampal granule cells through the activation of hilar astrocytes.
      Citation: Nature Reviews Neuroscience 17, 400 (2016)
      PubDate: 2016-05-26
      DOI: 10.1038/nrn.2016.72
      Issue No: Vol. 17, No. 7 (2016)
       
  • Somatostatin-expressing neurons in cortical networks
    • Authors: Joanna Urban-Ciecko, Alison L. Barth
      Pages: 401 - 409
      Abstract: Somatostatin-expressing GABAergic neurons constitute a major class of inhibitory neurons in the mammalian cortex and are characterized by dense wiring into the local network and high basal firing activity that persists in the absence of synaptic input. This firing provides both GABA type A receptor
      Citation: Nature Reviews Neuroscience 17, 401 (2016)
      PubDate: 2016-05-26
      DOI: 10.1038/nrn.2016.53
      Issue No: Vol. 17, No. 7 (2016)
       
  • The landscape of DNA methylation amid a perfect storm of autism
           aetiologies
    • Authors: Annie Vogel Ciernia, Janine LaSalle
      Pages: 411 - 423
      Abstract: Increasing evidence points to a complex interplay between genes and the environment in autism spectrum disorder (ASD), including rare de novo mutations in chromatin genes such as methyl-CpG binding protein 2 (MECP2) in Rett syndrome. Epigenetic mechanisms such as DNA methylation act
      Citation: Nature Reviews Neuroscience 17, 411 (2016)
      PubDate: 2016-05-06
      DOI: 10.1038/nrn.2016.41
      Issue No: Vol. 17, No. 7 (2016)
       
  • Evaluating cell reprogramming, differentiation and conversion technologies
           in neuroscience
    • Authors: Jerome Mertens, Maria C. Marchetto, Cedric Bardy, Fred H. Gage
      Pages: 424 - 437
      Abstract: The scarcity of live human brain cells for experimental access has for a long time limited our ability to study complex human neurological disorders and elucidate basic neuroscientific mechanisms. A decade ago, the development of methods to reprogramme somatic human cells into induced pluripotent stem
      Citation: Nature Reviews Neuroscience 17, 424 (2016)
      PubDate: 2016-05-19
      DOI: 10.1038/nrn.2016.46
      Issue No: Vol. 17, No. 7 (2016)
       
  • The neuroscience of working memory capacity and training
    • Authors: Christos Constantinidis, Torkel Klingberg
      Pages: 438 - 449
      Abstract: Working memory — the ability to maintain and manipulate information over a period of seconds — is a core component of higher cognitive functions. The storage capacity of working memory is limited but can be expanded by training, and evidence of the neural mechanisms underlying
      Citation: Nature Reviews Neuroscience 17, 438 (2016)
      PubDate: 2016-05-26
      DOI: 10.1038/nrn.2016.43
      Issue No: Vol. 17, No. 7 (2016)
       
  • Integrated information theory: from consciousness to its physical
           substrate
    • Authors: Giulio Tononi, Melanie Boly, Marcello Massimini, Christof Koch
      Pages: 450 - 461
      Abstract: In this Opinion article, we discuss how integrated information theory accounts for several aspects of the relationship between consciousness and the brain. Integrated information theory starts from the essential properties of phenomenal experience, from which it derives the requirements for the physical substrate of consciousness.
      Citation: Nature Reviews Neuroscience 17, 450 (2016)
      PubDate: 2016-05-26
      DOI: 10.1038/nrn.2016.44
      Issue No: Vol. 17, No. 7 (2016)
       
 
 
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